Gene Set Name |
GeneSetDescription |
Value |
Gene Set Size |
Corrected Value |
Ranking |
Description |
URL |
Broad ONDER_CDH1_TARGETS_2_DN |
View Gene Set
|
5.464e-23 |
453 |
1.307e-19 |
1 |
Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. |
www.broad.mit.e...
|
Broad COLDREN_GEFITINIB_RESISTANCE_DN |
View Gene Set
|
3.708e-16 |
217 |
4.435e-13 |
2 |
Genes down-regulated in NSCLC (non-small cell lung carcinoma) cell lines resistant to gefitinib [PubChem=123631] compared to the sensitive ones. |
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_UP |
View Gene Set
|
1.572e-10 |
114 |
1.253e-07 |
3 |
Genes up-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones. |
www.broad.mit.e...
|
Broad BROWNE_INTERFERON_RESPONSIVE_GENES |
View Gene Set
|
1.602e-09 |
67 |
9.579e-07 |
4 |
Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h. |
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP |
View Gene Set
|
1.725e-08 |
422 |
8.251e-06 |
5 |
Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. |
www.broad.mit.e...
|
Broad MOSERLE_IFNA_RESPONSE |
View Gene Set
|
2.867e-08 |
30 |
9.795e-06 |
6 |
Top 50 genes up-regulated in ovarian cancer progenitor cells (also known as side population
SP
cells) in response to interferon alpha (IFNA).
|
www.broad.mit.e...
|
Broad CHANG_IMMORTALIZED_BY_HPV31_DN |
View Gene Set
|
2.81e-08 |
47 |
9.795e-06 |
6 |
Genes down-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain. |
www.broad.mit.e...
|
Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN |
View Gene Set
|
5.933e-08 |
317 |
1.774e-05 |
8 |
The postradiation tumor escape signature: genes down-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. |
www.broad.mit.e...
|
Broad BASAKI_YBX1_TARGETS_DN |
View Gene Set
|
8.158e-08 |
356 |
1.978e-05 |
9 |
Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [Gene ID=4904] knockdown by RNAi. |
www.broad.mit.e...
|
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP |
View Gene Set
|
8.271e-08 |
716 |
1.978e-05 |
9 |
Genes up-regulated in HL-60 cells (acute promyelocytic leukemia
APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h.
|
www.broad.mit.e...
|
Broad DELYS_THYROID_CANCER_UP |
View Gene Set
|
1.737e-07 |
397 |
3.778e-05 |
11 |
Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. |
www.broad.mit.e...
|
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 |
View Gene Set
|
3.502e-07 |
681 |
6.981e-05 |
12 |
The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
2064].
|
www.broad.mit.e...
|
Broad DAUER_STAT3_TARGETS_DN |
View Gene Set
|
4.696e-07 |
37 |
8.641e-05 |
13 |
Top 50 genes down-regulated in A549 cells (lung cancer) expressing STAT3 [Gene ID=6774] off an adenovirus vector. |
www.broad.mit.e...
|
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN |
View Gene Set
|
6.445e-07 |
571 |
0.0001101 |
14 |
Genes down-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. |
www.broad.mit.e...
|
Broad GALE_APL_WITH_FLT3_MUTATED_DN |
View Gene Set
|
2.821e-06 |
17 |
0.0004499 |
15 |
Genes down-regulated in acute promyelocytic leukemia (APL) patients with mutated FLT3 [Gene ID=2322]. |
www.broad.mit.e...
|
Broad RODRIGUES_DCC_TARGETS_DN |
View Gene Set
|
3.703e-06 |
121 |
0.0004921 |
16 |
Genes down-regulated in HCT8/S1 cells (colon cancer) which normally lack DCC [Gene ID=9423] compared to those stably expressing wild type DCC off a plasmid vector. |
www.broad.mit.e...
|
Broad BOWIE_RESPONSE_TO_TAMOXIFEN |
View Gene Set
|
3.346e-06 |
14 |
0.0004921 |
16 |
Genes up-regulated by tamoxifen [PubChem=5376] in HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]). |
www.broad.mit.e...
|
Broad WU_CELL_MIGRATION |
View Gene Set
|
3.585e-06 |
182 |
0.0004921 |
16 |
Genes associated with migration rate of 40 human bladder cancer cells. |
www.broad.mit.e...
|
Broad ZHANG_INTERFERON_RESPONSE |
View Gene Set
|
4.254e-06 |
21 |
0.0005355 |
19 |
Interferon-inducible genes up-regulated in A549 cells (lung cancer) infected with a respiratory syncytial virus (RSV) that had its NS1 [Gene ID=1494468] gene knocked down by RNAi. |
www.broad.mit.e...
|
Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN |
View Gene Set
|
4.859e-06 |
155 |
0.0005811 |
20 |
Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. |
www.broad.mit.e...
|
Broad EINAV_INTERFERON_SIGNATURE_IN_CANCER |
View Gene Set
|
6.045e-06 |
27 |
0.0006885 |
21 |
A gene expression signature found in a subset of cancer patients suggestive of a deregulated immune or inflammatory response. |
www.broad.mit.e...
|
Broad UROSEVIC_RESPONSE_TO_IMIQUIMOD |
View Gene Set
|
8.556e-06 |
16 |
0.0009303 |
22 |
Interferon cluster genes up-regulated in skin tumors treated with imiquimod [PubChem=57469]. |
www.broad.mit.e...
|
Broad TSAI_DNAJB4_TARGETS_UP |
View Gene Set
|
9.03e-06 |
13 |
0.0009391 |
23 |
Genes up-regulated in CL1-5 cells (lung cancer) overexpressing DNAJB4 [Gene ID=11080] off a plasmid vector. |
www.broad.mit.e...
|
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP |
View Gene Set
|
1.061e-05 |
869 |
0.001058 |
24 |
Genes up-regulated in HL-60 cells (acute promyelocytic leukemia
APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h.
|
www.broad.mit.e...
|
Broad AIGNER_ZEB1_TARGETS |
View Gene Set
|
1.153e-05 |
29 |
0.001061 |
25 |
Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of ZEB1 [Gene ID=6935] by RNAi. |
www.broad.mit.e...
|
Broad BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
View Gene Set
|
1.144e-05 |
23 |
0.001061 |
25 |
Genes significantly up-regulated in the blood mononuclear cells from patients with systemic lupus erythematosus compared to those from healthy persons. |
www.broad.mit.e...
|
Broad SANA_TNF_SIGNALING_UP |
View Gene Set
|
1.249e-05 |
75 |
0.001106 |
27 |
Genes up-regulated in five primary endothelial cell types (lung
aortic
iliac
dermal
and colon) by TNF [Gene ID=7124].
|
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN |
View Gene Set
|
1.786e-05 |
437 |
0.001526 |
28 |
Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. |
www.broad.mit.e...
|
Broad BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX |
View Gene Set
|
2.079e-05 |
10 |
0.001715 |
29 |
Genes up-regulated by growing HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]) in extracellular matrix (ECM). |
www.broad.mit.e...
|
Broad TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP |
View Gene Set
|
3.147e-05 |
182 |
0.002509 |
30 |
Genes up-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [Gene ID=861
862] fusion.
|
www.broad.mit.e...
|
Broad SEKI_INFLAMMATORY_RESPONSE_LPS_UP |
View Gene Set
|
4.69e-05 |
75 |
0.003619 |
31 |
Genes up-regulated in hepatic stellar cells after stimulation with bacterial lipopolysacharide (LPS). |
www.broad.mit.e...
|
Broad STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN |
View Gene Set
|
5.287e-05 |
437 |
0.003832 |
32 |
Genes down-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region. |
www.broad.mit.e...
|
Broad MOOTHA_MITOCHONDRIA |
View Gene Set
|
5.153e-05 |
433 |
0.003832 |
32 |
Mitochondrial genes |
www.broad.mit.e...
|
Broad JAEGER_METASTASIS_DN |
View Gene Set
|
8.072e-05 |
252 |
0.005081 |
34 |
Genes down-regulated in metastases from malignant melanoma compared to the primary tumors. |
www.broad.mit.e...
|
Broad ENK_UV_RESPONSE_KERATINOCYTE_UP |
View Gene Set
|
7.973e-05 |
517 |
0.005081 |
34 |
Genes up-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. |
www.broad.mit.e...
|
Broad LE_EGR2_TARGETS_DN |
View Gene Set
|
7.784e-05 |
100 |
0.005081 |
34 |
Genes down-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [Gene ID=1959]. |
www.broad.mit.e...
|
Broad KIM_LRRC3B_TARGETS |
View Gene Set
|
7.825e-05 |
30 |
0.005081 |
34 |
Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135]. |
www.broad.mit.e...
|
Broad MASSARWEH_TAMOXIFEN_RESISTANCE_UP |
View Gene Set
|
7.428e-05 |
531 |
0.005081 |
34 |
Genes up-regulated in breast cancer tumors (formed by MCF-7 xenografts) resistant to tamoxifen [PubChem=5376]. |
www.broad.mit.e...
|
Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN |
View Gene Set
|
9.216e-05 |
296 |
0.005511 |
39 |
Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue. |
www.broad.mit.e...
|
Broad FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN |
View Gene Set
|
9.025e-05 |
431 |
0.005511 |
39 |
Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin
LGALS1) [Gene ID=3956] compared to that with bacterial lipopolysaccharide (LPS).
|
www.broad.mit.e...
|
Broad MOOTHA_HUMAN_MITODB_6_2002 |
View Gene Set
|
0.0001031 |
420 |
0.006016 |
41 |
Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
www.broad.mit.e...
|
Broad ALCALA_APOPTOSIS |
View Gene Set
|
0.0001063 |
87 |
0.006052 |
42 |
Genes able to induce cell death in an expression cDNA library screen. |
www.broad.mit.e...
|
Broad DODD_NASOPHARYNGEAL_CARCINOMA_UP |
View Gene Set
|
0.0001215 |
1582 |
0.00632 |
43 |
Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. |
www.broad.mit.e...
|
Broad LANDIS_BREAST_CANCER_PROGRESSION_UP |
View Gene Set
|
0.000114 |
42 |
0.00632 |
43 |
Genes up-regulated in preneoplastic mammary tissues and whose expression is maintained in tumors. |
www.broad.mit.e...
|
Broad SANA_RESPONSE_TO_IFNG_UP |
View Gene Set
|
0.0001172 |
68 |
0.00632 |
43 |
Genes up-regulated in five primary endothelial cell types (lung
aortic
iliac
dermal
and colon) by IFNG [Gene ID=3458].
|
www.broad.mit.e...
|
Broad HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN |
View Gene Set
|
0.0001199 |
70 |
0.00632 |
43 |
Genes down-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [Gene ID=3205
4211].
|
www.broad.mit.e...
|
Broad GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP |
View Gene Set
|
0.0001454 |
38 |
0.007244 |
47 |
Genes up-regulated in common hematopoietic progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [Gene ID=6223]. |
www.broad.mit.e...
|
Broad FURUKAWA_DUSP6_TARGETS_PCI35_UP |
View Gene Set
|
0.0001449 |
64 |
0.007244 |
47 |
Genes up-regulated in PCI-35 cells (pancreatic cancer
lack endogenous DUSP6 [Gene ID=1848]) upon expression of DUSP6 off an adenoviral vector.
|
www.broad.mit.e...
|
Broad TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_UP |
View Gene Set
|
0.0001687 |
20 |
0.008237 |
49 |
Genes up-regulated by RUNX1-RUNX1T1 [Gene ID=861
862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing monocytes.
|
www.broad.mit.e...
|
Broad CAIRO_LIVER_DEVELOPMENT_DN |
View Gene Set
|
0.0002183 |
208 |
0.01044 |
50 |
Genes down-regulated at early fetal liver stage (embryonic days E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5). |
www.broad.mit.e...
|
Broad THUM_SYSTOLIC_HEART_FAILURE_UP |
View Gene Set
|
0.0002368 |
393 |
0.0105 |
51 |
Genes up-regulated in samples with systolic heart failure compared to normal hearts. |
www.broad.mit.e...
|
Broad NUYTTEN_NIPP1_TARGETS_UP |
View Gene Set
|
0.0002311 |
657 |
0.0105 |
51 |
Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. |
www.broad.mit.e...
|
Broad WELCSH_BRCA1_TARGETS_1_UP |
View Gene Set
|
0.000237 |
171 |
0.0105 |
51 |
Upregulated by induction of exogenous BRCA1 in EcR-293 cells |
www.broad.mit.e...
|
Broad JI_RESPONSE_TO_FSH_UP |
View Gene Set
|
0.0002311 |
54 |
0.0105 |
51 |
Genes up-regulated in MCV152 cells (ovarian cancer) treated with follicle stimulating hormone (FSH). |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP |
View Gene Set
|
0.0002449 |
174 |
0.01065 |
55 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 3 days after transduction.
|
www.broad.mit.e...
|
Broad LIANG_SILENCED_BY_METHYLATION_2 |
View Gene Set
|
0.0002495 |
35 |
0.01066 |
56 |
Genes up-regulated in T24 cells (bladder carcinoma) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. |
www.broad.mit.e...
|
Broad JISON_SICKLE_CELL_DISEASE_UP |
View Gene Set
|
0.0002626 |
175 |
0.01102 |
57 |
Genes up-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects. |
www.broad.mit.e...
|
Broad LINDSTEDT_DENDRITIC_CELL_MATURATION_A |
View Gene Set
|
0.0002731 |
54 |
0.01126 |
58 |
Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 8 hr after the stimulation (cluster A). |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP |
View Gene Set
|
0.0002899 |
186 |
0.01137 |
59 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 10 days after transduction.
|
www.broad.mit.e...
|
Broad LANDIS_ERBB2_BREAST_TUMORS_324_UP |
View Gene Set
|
0.0002884 |
132 |
0.01137 |
59 |
The 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [Gene ID=2064]. |
www.broad.mit.e...
|
Broad KIM_MYCN_AMPLIFICATION_TARGETS_DN |
View Gene Set
|
0.00029 |
78 |
0.01137 |
59 |
Genes negatively correlated with amplifications of MYCN [Gene ID=4613] in the SCLC (small cell lung cancer) cell lines. |
www.broad.mit.e...
|
Broad SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP |
View Gene Set
|
0.0003518 |
72 |
0.01351 |
62 |
Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p). |
www.broad.mit.e...
|
Broad ROZANOV_MMP14_TARGETS_UP |
View Gene Set
|
0.000358 |
260 |
0.01351 |
62 |
Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [Gene ID=4323] compared to those with knockdown of the gene by RNAi. |
www.broad.mit.e...
|
Broad WANG_CISPLATIN_RESPONSE_AND_XPC_UP |
View Gene Set
|
0.0003616 |
135 |
0.01351 |
62 |
Genes up-regulated in fibroblasts with defective XPC [Gene ID=7508] in response to cisplatin [PubChem=2767]. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_BASAL_DN |
View Gene Set
|
0.0003761 |
664 |
0.01384 |
65 |
Genes down-regulated in basal subtype of breast cancer samles. |
www.broad.mit.e...
|
Broad RUIZ_TNC_TARGETS_UP |
View Gene Set
|
0.000388 |
145 |
0.01406 |
66 |
Genes up-regulated in T98G cells (glioblastoma) by TNC [Gene ID=3371]. |
www.broad.mit.e...
|
Broad MAHADEVAN_RESPONSE_TO_MP470_UP |
View Gene Set
|
0.0004449 |
19 |
0.01572 |
67 |
Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] after treatment with MP470
a protein kinase inhibitor.
|
www.broad.mit.e...
|
Broad KOBAYASHI_EGFR_SIGNALING_24HR_UP |
View Gene Set
|
0.0004469 |
96 |
0.01572 |
67 |
Genes up-regulated in H1975 cells (non-small cell lung cancer
NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h.
|
www.broad.mit.e...
|
Broad BRUECKNER_TARGETS_OF_MIRLET7A3_UP |
View Gene Set
|
0.0005035 |
105 |
0.01746 |
69 |
Genes up-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [Gene ID=406883] microRNA off a plasmid vector. |
www.broad.mit.e...
|
Broad ELVIDGE_HYPOXIA_UP |
View Gene Set
|
0.0005412 |
163 |
0.01849 |
70 |
Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. |
www.broad.mit.e...
|
Broad BILD_HRAS_ONCOGENIC_SIGNATURE |
View Gene Set
|
0.0005874 |
248 |
0.01979 |
71 |
Genes selected in supervised analyses to discriminate cells expressing activated HRAS [Gene ID=3265] oncogene from control cells expressing GFP. |
www.broad.mit.e...
|
Broad SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 |
View Gene Set
|
0.0005995 |
407 |
0.01992 |
72 |
Genes up-regulated in the pancreatic cancer cell lines (AsPC1
Hs766T
MiaPaCa2
Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].
|
www.broad.mit.e...
|
Broad DOANE_BREAST_CANCER_ESR1_UP |
View Gene Set
|
0.0006728 |
104 |
0.02179 |
73 |
Genes changed in breast cancer samples according to the ESR1 [Gene ID=2099] status: ER positive vs ER negative tumors. |
www.broad.mit.e...
|
Broad NUYTTEN_EZH2_TARGETS_UP |
View Gene Set
|
0.0006744 |
944 |
0.02179 |
73 |
Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. |
www.broad.mit.e...
|
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 |
View Gene Set
|
0.0006832 |
158 |
0.02179 |
73 |
Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13. |
www.broad.mit.e...
|
Broad DER_IFN_ALPHA_RESPONSE_UP |
View Gene Set
|
0.000716 |
57 |
0.02224 |
76 |
Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. |
www.broad.mit.e...
|
Broad ROETH_TERT_TARGETS_UP |
View Gene Set
|
0.0007154 |
8 |
0.02224 |
76 |
Genes up-regulated in T lymphocytes overexpressing TERT [Gene ID=7015] off a retrovirus vector. |
www.broad.mit.e...
|
Broad HOSHIDA_LIVER_CANCER_SUBCLASS_S3 |
View Gene Set
|
0.000751 |
266 |
0.02253 |
78 |
Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. |
www.broad.mit.e...
|
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 |
View Gene Set
|
0.0007437 |
68 |
0.02253 |
78 |
Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 9. |
www.broad.mit.e...
|
Broad ZHAN_MULTIPLE_MYELOMA_HP_UP |
View Gene Set
|
0.0007536 |
44 |
0.02253 |
78 |
Top 50 up-regulated genes in cluster HP of multiple myeloma samples characterized by a hyperploid signature. |
www.broad.mit.e...
|
Broad BECKER_TAMOXIFEN_RESISTANCE_UP |
View Gene Set
|
0.0008016 |
38 |
0.02367 |
81 |
Genes up-regulated in a breast cancer cell line resistant to tamoxifen [PubChem ID=5376] compared to the parental line sensitive to the drug. |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP |
View Gene Set
|
0.0008188 |
153 |
0.02389 |
82 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 8 days after transduction.
|
www.broad.mit.e...
|
Broad MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 |
View Gene Set
|
0.0008545 |
23 |
0.02463 |
83 |
Cluster 5: genes up-regulated in SW260 cells (colon cancer) by curcumin and sulindac [PubChem=969516
5352].
|
www.broad.mit.e...
|
Broad ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP |
View Gene Set
|
0.001031 |
78 |
0.02833 |
84 |
Genes up-regulated in P493-6 cells (B lymphocyte) by MYC [Gene ID=4609] and down-regulated by RNAi knockdown of TFRC [Gene ID=7037]. |
www.broad.mit.e...
|
Broad ELVIDGE_HYPOXIA_BY_DMOG_UP |
View Gene Set
|
0.001027 |
125 |
0.02833 |
84 |
Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. |
www.broad.mit.e...
|
Broad MARKS_HDAC_TARGETS_UP |
View Gene Set
|
0.001056 |
21 |
0.02833 |
84 |
Genes whose transcription is altered by histone deacetylase inhibitors. |
www.broad.mit.e...
|
Broad ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP |
View Gene Set
|
0.001033 |
208 |
0.02833 |
84 |
Genes up-regulated in BxPC3 cells (pancreatic cancer) after treatment with TNF [Gene ID=7124] or IKI-1
an inhibitor of I?B kinase (IKK).
|
www.broad.mit.e...
|
Broad ONDER_CDH1_TARGETS_1_UP |
View Gene Set
|
0.001041 |
131 |
0.02833 |
84 |
Genes up-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [Gene ID=999]. |
www.broad.mit.e...
|
Broad RADAEVA_RESPONSE_TO_IFNA1_UP |
View Gene Set
|
0.001056 |
32 |
0.02833 |
84 |
Genes up-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [Gene ID=3439]. |
www.broad.mit.e...
|
Broad KRASNOSELSKAYA_ILF3_TARGETS_UP |
View Gene Set
|
0.001066 |
31 |
0.02833 |
84 |
Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [Gene ID=3609]. |
www.broad.mit.e...
|
Broad GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3 |
View Gene Set
|
0.001125 |
11 |
0.02925 |
91 |
Genes up-regulated in Jurkat cells (T lymphocyte) by IFN1@
and IFNB1 [Gene ID=3438
3456] but not by overexpression of a constitutively active form of IRF3 [Gene ID=3661].
|
www.broad.mit.e...
|
Broad HINATA_NFKB_TARGETS_KERATINOCYTE_UP |
View Gene Set
|
0.001119 |
71 |
0.02925 |
91 |
Genes up-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [Gene ID=4790
5970] components of NFKB.
|
www.broad.mit.e...
|
Broad STEIN_ESRRA_TARGETS_UP |
View Gene Set
|
0.001173 |
368 |
0.03018 |
93 |
Genes up-regulated by ESRRA [Gene ID=2101] only. |
www.broad.mit.e...
|
Broad KORKOLA_YOLK_SAC_TUMOR |
View Gene Set
|
0.00126 |
49 |
0.03206 |
94 |
Genes predicting the yolk sac tumor (YS) subtype of nonseminomatous male germ cell tumors (NSGCT). |
www.broad.mit.e...
|
Broad PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN |
View Gene Set
|
0.001275 |
140 |
0.0321 |
95 |
Genes down-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion. |
www.broad.mit.e...
|
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN |
View Gene Set
|
0.001299 |
532 |
0.03237 |
96 |
Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. |
www.broad.mit.e...
|
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_UP |
View Gene Set
|
0.001313 |
99 |
0.03238 |
97 |
Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668]
a DNA hypomethylating agent similar to azacitidine [PubChem=9444].
|
www.broad.mit.e...
|
Broad TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_DN |
View Gene Set
|
0.001349 |
8 |
0.03293 |
98 |
Genes down-regulated by RUNX1-RUNX1T1 [Gene ID=861
862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing monocytes.
|
www.broad.mit.e...
|
Broad ONDER_CDH1_SIGNALING_VIA_CTNNB1 |
View Gene Set
|
0.001408 |
81 |
0.03402 |
99 |
Genes changed in HMLE cells (mmortalized nontransformed mammary epithelium) after RNAi knockdown of both CDH1 [Gene ID=999] and CTNNB1 [Gene ID=1499]
compared to the knockdown of CDH1 alone.
|
www.broad.mit.e...
|
Broad GAJATE_RESPONSE_TO_TRABECTEDIN_UP |
View Gene Set
|
0.001587 |
53 |
0.03796 |
100 |
Genes up-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199]. |
www.broad.mit.e...
|
Broad BASSO_CD40_SIGNALING_UP |
View Gene Set
|
0.001611 |
100 |
0.03816 |
101 |
Gene changed by CD40 [Gene ID=958] signaling in Ramos cells (EBV negative Burkitt lymphoma). |
www.broad.mit.e...
|
Broad THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP |
View Gene Set
|
0.001653 |
76 |
0.03876 |
102 |
Genes up-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds. |
www.broad.mit.e...
|
Broad HOOI_ST7_TARGETS_DN |
View Gene Set
|
0.001717 |
108 |
0.03988 |
103 |
Genes down-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [Gene ID=7982] off a plasmid vector. |
www.broad.mit.e...
|
Broad NEWMAN_ERCC6_TARGETS_UP |
View Gene Set
|
0.001852 |
25 |
0.0426 |
104 |
Genes up-regulated in Cockayne syndrome fibroblasts rescued by expression of ERCC6 [Gene ID=2074] off a plasmid vector. |
www.broad.mit.e...
|
Broad WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP |
View Gene Set
|
0.001986 |
131 |
0.0444 |
105 |
Genes up-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue. |
www.broad.mit.e...
|
Broad YANAGIHARA_ESX1_TARGETS |
View Gene Set
|
0.001972 |
23 |
0.0444 |
105 |
Genes down-regulated in U2-OS Tet-On cells (osteosarcoma) after induction of ESX1 [Gene ID=80712] expression. |
www.broad.mit.e...
|
Broad WIELAND_UP_BY_HBV_INFECTION |
View Gene Set
|
0.001958 |
98 |
0.0444 |
105 |
Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees. |
www.broad.mit.e...
|
Broad TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN |
View Gene Set
|
0.002084 |
52 |
0.04616 |
108 |
Genes down-regulated in monocytes by RUNX1-RUNX1T1 [Gene ID=861
862] fusion.
|
www.broad.mit.e...
|
Broad TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP |
View Gene Set
|
0.002165 |
43 |
0.0475 |
109 |
Genes up-regulated by RUNX1-RUNX1T1 [Gene ID=861
862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing erythroid lineage.
|
www.broad.mit.e...
|
Broad SENESE_HDAC3_TARGETS_UP |
View Gene Set
|
0.002223 |
471 |
0.04835 |
110 |
Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC3 [Gene ID=8841] by RNAi. |
www.broad.mit.e...
|