Gene Set Name |
GeneSetDescription |
Value |
Gene Set Size |
Corrected Value |
Ranking |
Description |
URL |
Broad BROWNE_INTERFERON_RESPONSIVE_GENES |
View Gene Set
|
3.134e-22 |
67 |
7.496e-19 |
1 |
Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h. |
www.broad.mit.e...
|
Broad MOSERLE_IFNA_RESPONSE |
View Gene Set
|
3.659e-18 |
30 |
4.377e-15 |
2 |
Top 50 genes up-regulated in ovarian cancer progenitor cells (also known as side population
SP
cells) in response to interferon alpha (IFNA).
|
www.broad.mit.e...
|
Broad WALLACE_PROSTATE_CANCER_RACE_UP |
View Gene Set
|
8.422e-16 |
288 |
6.715e-13 |
3 |
Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. |
www.broad.mit.e...
|
Broad FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN |
View Gene Set
|
4.395e-14 |
431 |
2.628e-11 |
4 |
Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin
LGALS1) [Gene ID=3956] compared to that with bacterial lipopolysaccharide (LPS).
|
www.broad.mit.e...
|
Broad NUYTTEN_EZH2_TARGETS_UP |
View Gene Set
|
6.216e-14 |
944 |
2.854e-11 |
5 |
Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. |
www.broad.mit.e...
|
Broad SANA_TNF_SIGNALING_UP |
View Gene Set
|
7.159e-14 |
75 |
2.854e-11 |
5 |
Genes up-regulated in five primary endothelial cell types (lung
aortic
iliac
dermal
and colon) by TNF [Gene ID=7124].
|
www.broad.mit.e...
|
Broad SANA_RESPONSE_TO_IFNG_UP |
View Gene Set
|
1.173e-13 |
68 |
4.007e-11 |
7 |
Genes up-regulated in five primary endothelial cell types (lung
aortic
iliac
dermal
and colon) by IFNG [Gene ID=3458].
|
www.broad.mit.e...
|
Broad SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP |
View Gene Set
|
1.871e-13 |
72 |
5.594e-11 |
8 |
Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p). |
www.broad.mit.e...
|
Broad DAUER_STAT3_TARGETS_DN |
View Gene Set
|
2.853e-12 |
37 |
7.582e-10 |
9 |
Top 50 genes down-regulated in A549 cells (lung cancer) expressing STAT3 [Gene ID=6774] off an adenovirus vector. |
www.broad.mit.e...
|
Broad ZHANG_INTERFERON_RESPONSE |
View Gene Set
|
4.322e-12 |
21 |
1.034e-09 |
10 |
Interferon-inducible genes up-regulated in A549 cells (lung cancer) infected with a respiratory syncytial virus (RSV) that had its NS1 [Gene ID=1494468] gene knocked down by RNAi. |
www.broad.mit.e...
|
Broad HORIUCHI_WTAP_TARGETS_UP |
View Gene Set
|
1.067e-11 |
284 |
2.321e-09 |
11 |
Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. |
www.broad.mit.e...
|
Broad ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP |
View Gene Set
|
1.148e-10 |
208 |
2.288e-08 |
12 |
Genes up-regulated in BxPC3 cells (pancreatic cancer) after treatment with TNF [Gene ID=7124] or IKI-1
an inhibitor of I?B kinase (IKK).
|
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP |
View Gene Set
|
1.34e-10 |
174 |
2.466e-08 |
13 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 3 days after transduction.
|
www.broad.mit.e...
|
Broad CHEN_HOXA5_TARGETS_9HR_UP |
View Gene Set
|
1.56e-10 |
210 |
2.665e-08 |
14 |
Differentially expressed genes 9 hr after tinduction of HoxA5 [Gene ID=3205] expression in a breast cancer cell line. |
www.broad.mit.e...
|
Broad BOWIE_RESPONSE_TO_TAMOXIFEN |
View Gene Set
|
2.605e-10 |
14 |
4.154e-08 |
15 |
Genes up-regulated by tamoxifen [PubChem=5376] in HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]). |
www.broad.mit.e...
|
Broad SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP |
View Gene Set
|
2.942e-10 |
339 |
4.398e-08 |
16 |
Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS
non-invasive).
|
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP |
View Gene Set
|
6.674e-10 |
186 |
9.084e-08 |
17 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 10 days after transduction.
|
www.broad.mit.e...
|
Broad MITSIADES_RESPONSE_TO_APLIDIN_UP |
View Gene Set
|
6.836e-10 |
413 |
9.084e-08 |
17 |
Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164]
a marine-derived compound with potential anti-cancer properties.
|
www.broad.mit.e...
|
Broad LIU_COMMON_CANCER_GENES |
View Gene Set
|
2.215e-09 |
43 |
2.789e-07 |
19 |
Low abundance transcripts common to nasopharyngeal carcinoma (NPC)
breast and liver tumors.
|
www.broad.mit.e...
|
Broad NUYTTEN_NIPP1_TARGETS_UP |
View Gene Set
|
3.083e-09 |
657 |
3.512e-07 |
20 |
Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. |
www.broad.mit.e...
|
Broad KIM_LRRC3B_TARGETS |
View Gene Set
|
2.973e-09 |
30 |
3.512e-07 |
20 |
Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135]. |
www.broad.mit.e...
|
Broad KERLEY_RESPONSE_TO_CISPLATIN_UP |
View Gene Set
|
4.175e-09 |
38 |
4.539e-07 |
22 |
Genes genes up-regulated in NT2/D1 cells (embryonal carcinoma) in response to treatment with cisplatin [PubChem=2767]. |
www.broad.mit.e...
|
Broad BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
View Gene Set
|
4.623e-09 |
23 |
4.808e-07 |
23 |
Genes significantly up-regulated in the blood mononuclear cells from patients with systemic lupus erythematosus compared to those from healthy persons. |
www.broad.mit.e...
|
Broad UROSEVIC_RESPONSE_TO_IMIQUIMOD |
View Gene Set
|
6.669e-09 |
16 |
6.647e-07 |
24 |
Interferon cluster genes up-regulated in skin tumors treated with imiquimod [PubChem=57469]. |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN |
View Gene Set
|
8.375e-09 |
133 |
8.013e-07 |
25 |
Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 16 days after transduction.
|
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN |
View Gene Set
|
1.008e-08 |
437 |
9.276e-07 |
26 |
Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_NORMAL_LIKE_UP |
View Gene Set
|
1.088e-08 |
459 |
9.641e-07 |
27 |
Genes up-regulated in the normal-like subtype of breast cancer. |
www.broad.mit.e...
|
Broad DER_IFN_ALPHA_RESPONSE_UP |
View Gene Set
|
2.779e-08 |
57 |
2.374e-06 |
28 |
Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. |
www.broad.mit.e...
|
Broad GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3 |
View Gene Set
|
3.178e-08 |
11 |
2.621e-06 |
29 |
Genes up-regulated in Jurkat cells (T lymphocyte) by IFN1@
and IFNB1 [Gene ID=3438
3456] but not by overexpression of a constitutively active form of IRF3 [Gene ID=3661].
|
www.broad.mit.e...
|
Broad LIU_PROSTATE_CANCER_DN |
View Gene Set
|
4.295e-08 |
446 |
3.425e-06 |
30 |
Genes down-regulated in prostate cancer samples. |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP |
View Gene Set
|
5.201e-08 |
153 |
4.013e-06 |
31 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 8 days after transduction.
|
www.broad.mit.e...
|
Broad DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN |
View Gene Set
|
6.791e-08 |
303 |
5.076e-06 |
32 |
Genes down-regulated in T-PLL cells (T-cell prolymphocytic leukemia) bearing the inv(14)/t(14:14) chromosomal aberration. |
www.broad.mit.e...
|
Broad BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX |
View Gene Set
|
1.202e-07 |
10 |
8.714e-06 |
33 |
Genes up-regulated by growing HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]) in extracellular matrix (ECM). |
www.broad.mit.e...
|
Broad PRAMOONJAGO_SOX4_TARGETS_UP |
View Gene Set
|
1.391e-07 |
49 |
9.789e-06 |
34 |
Genes up-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [Gene ID=6659] by RNAi. |
www.broad.mit.e...
|
Broad PEREZ_TP53_TARGETS |
View Gene Set
|
1.467e-07 |
1066 |
1.002e-05 |
35 |
Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [Gene ID=7157] off adenoviral vector. |
www.broad.mit.e...
|
Broad WIELAND_UP_BY_HBV_INFECTION |
View Gene Set
|
1.853e-07 |
98 |
1.232e-05 |
36 |
Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees. |
www.broad.mit.e...
|
Broad MCLACHLAN_DENTAL_CARIES_DN |
View Gene Set
|
2.751e-07 |
234 |
1.778e-05 |
37 |
Genes down-regulated in pulpal tissue extracted from carious teeth. |
www.broad.mit.e...
|
Broad ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP |
View Gene Set
|
3.586e-07 |
93 |
2.257e-05 |
38 |
Hepatic graft versus host disease (GVHD)
day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant.
|
www.broad.mit.e...
|
Broad FUJII_YBX1_TARGETS_UP |
View Gene Set
|
4.161e-07 |
27 |
2.552e-05 |
39 |
Genes up-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [Gene ID=4904] by RNAi. |
www.broad.mit.e...
|
Broad BASSO_HAIRY_CELL_LEUKEMIA_DN |
View Gene Set
|
4.793e-07 |
78 |
2.866e-05 |
40 |
Genes down-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations. |
www.broad.mit.e...
|
Broad ZHU_CMV_8_HR_UP |
View Gene Set
|
5.018e-07 |
32 |
2.927e-05 |
41 |
Up-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV |
www.broad.mit.e...
|
Broad PODAR_RESPONSE_TO_ADAPHOSTIN_UP |
View Gene Set
|
5.702e-07 |
140 |
3.248e-05 |
42 |
Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042]
a tyrosine kinase inhibitor with anticancer properties.
|
www.broad.mit.e...
|
Broad KRASNOSELSKAYA_ILF3_TARGETS_UP |
View Gene Set
|
7.299e-07 |
31 |
4.06e-05 |
43 |
Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [Gene ID=3609]. |
www.broad.mit.e...
|
Broad EINAV_INTERFERON_SIGNATURE_IN_CANCER |
View Gene Set
|
7.661e-07 |
27 |
4.165e-05 |
44 |
A gene expression signature found in a subset of cancer patients suggestive of a deregulated immune or inflammatory response. |
www.broad.mit.e...
|
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN |
View Gene Set
|
1.083e-06 |
732 |
5.755e-05 |
45 |
Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. |
www.broad.mit.e...
|
Broad GOZGIT_ESR1_TARGETS_DN |
View Gene Set
|
1.31e-06 |
710 |
6.666e-05 |
46 |
Genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [Gene ID=2099]) compared to the parental MCF7 cells which do. |
www.broad.mit.e...
|
Broad LIANG_SILENCED_BY_METHYLATION_2 |
View Gene Set
|
1.29e-06 |
35 |
6.666e-05 |
46 |
Genes up-regulated in T24 cells (bladder carcinoma) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. |
www.broad.mit.e...
|
Broad YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP |
View Gene Set
|
1.488e-06 |
130 |
7.414e-05 |
48 |
Genes up-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag
a hedgehog (Hh) pathway inhibitor.
|
www.broad.mit.e...
|
Broad MAHADEVAN_RESPONSE_TO_MP470_UP |
View Gene Set
|
1.526e-06 |
19 |
7.448e-05 |
49 |
Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] after treatment with MP470
a protein kinase inhibitor.
|
www.broad.mit.e...
|
Broad RADAEVA_RESPONSE_TO_IFNA1_UP |
View Gene Set
|
1.616e-06 |
32 |
7.733e-05 |
50 |
Genes up-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [Gene ID=3439]. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_LUMINAL_B_DN |
View Gene Set
|
1.702e-06 |
549 |
7.982e-05 |
51 |
Genes down-regulated in the luminal B subtype of breast cancer. |
www.broad.mit.e...
|
Broad LEE_NEURAL_CREST_STEM_CELL_DN |
View Gene Set
|
3.059e-06 |
114 |
0.0001407 |
52 |
Genes down-regulated in the neural crest stem cells (NCS)
defined as p75+/HNK1+ [Gene ID=4804
27087].
|
www.broad.mit.e...
|
Broad HELLER_SILENCED_BY_METHYLATION_UP |
View Gene Set
|
4.268e-06 |
247 |
0.0001926 |
53 |
Genes up-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. |
www.broad.mit.e...
|
Broad VECCHI_GASTRIC_CANCER_EARLY_DN |
View Gene Set
|
4.567e-06 |
346 |
0.0002017 |
54 |
Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. |
www.broad.mit.e...
|
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_UP |
View Gene Set
|
4.638e-06 |
99 |
0.0002017 |
54 |
Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668]
a DNA hypomethylating agent similar to azacitidine [PubChem=9444].
|
www.broad.mit.e...
|
Broad SPIRA_SMOKERS_LUNG_CANCER_DN |
View Gene Set
|
4.88e-06 |
20 |
0.0002084 |
56 |
Down-regulated genes that distinguished smokers with and without lung cancer. |
www.broad.mit.e...
|
Broad RUIZ_TNC_TARGETS_UP |
View Gene Set
|
4.991e-06 |
145 |
0.0002094 |
57 |
Genes up-regulated in T98G cells (glioblastoma) by TNC [Gene ID=3371]. |
www.broad.mit.e...
|
Broad MCLACHLAN_DENTAL_CARIES_UP |
View Gene Set
|
6.121e-06 |
207 |
0.0002524 |
58 |
Genes up-regulated in pulpal tissue extracted from carious teeth. |
www.broad.mit.e...
|
Broad ELVIDGE_HYPOXIA_BY_DMOG_UP |
View Gene Set
|
6.442e-06 |
125 |
0.0002612 |
59 |
Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. |
www.broad.mit.e...
|
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN |
View Gene Set
|
6.991e-06 |
93 |
0.0002787 |
60 |
Genes down-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. |
www.broad.mit.e...
|
Broad SCHAVOLT_TARGETS_OF_TP53_AND_TP63 |
View Gene Set
|
7.961e-06 |
16 |
0.0003102 |
61 |
Genes up-regulated by TP53 [Gene ID=7157] and down-regulated by an isoform of TP63 [Gene ID=8626] in primary HEK cells (epidermal keratinocytes). |
www.broad.mit.e...
|
Broad HINATA_NFKB_TARGETS_KERATINOCYTE_UP |
View Gene Set
|
8.041e-06 |
71 |
0.0003102 |
61 |
Genes up-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [Gene ID=4790
5970] components of NFKB.
|
www.broad.mit.e...
|
Broad UDAYAKUMAR_MED1_TARGETS_DN |
View Gene Set
|
8.954e-06 |
230 |
0.0003347 |
63 |
Genes down-regulated in HeLa cells after knockdown of MED1 [Gene ID=5469] by RNAi. |
www.broad.mit.e...
|
Broad ROETH_TERT_TARGETS_UP |
View Gene Set
|
8.822e-06 |
8 |
0.0003347 |
63 |
Genes up-regulated in T lymphocytes overexpressing TERT [Gene ID=7015] off a retrovirus vector. |
www.broad.mit.e...
|
Broad LINDGREN_BLADDER_CANCER_CLUSTER_2B |
View Gene Set
|
9.681e-06 |
384 |
0.0003562 |
65 |
Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. |
www.broad.mit.e...
|
Broad MARKEY_RB1_ACUTE_LOF_UP |
View Gene Set
|
1.298e-05 |
202 |
0.0004705 |
66 |
Genes up-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. |
www.broad.mit.e...
|
Broad GEISS_RESPONSE_TO_DSRNA_UP |
View Gene Set
|
1.353e-05 |
32 |
0.0004829 |
67 |
Genes up-pregulated by dsRNA in GRE cells (glioma; no interferon system). |
www.broad.mit.e...
|
Broad LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP |
View Gene Set
|
1.573e-05 |
178 |
0.0005535 |
68 |
Genes up-regulated in Wilm's tumor samples compared to fetal kidney. |
www.broad.mit.e...
|
Broad GAURNIER_PSMD4_TARGETS |
View Gene Set
|
1.712e-05 |
59 |
0.0005936 |
69 |
Inflammatory cytokines
chemokines and their cognate receptors up-regulated in THP-1 cells (monocyte) after treatment with PSMD4 [Gene ID=5710].
|
www.broad.mit.e...
|
Broad FRIDMAN_IMMORTALIZATION_DN |
View Gene Set
|
1.803e-05 |
32 |
0.0006163 |
70 |
Genes down-regulated in immortalized cell lines. |
www.broad.mit.e...
|
Broad SEKI_INFLAMMATORY_RESPONSE_LPS_UP |
View Gene Set
|
1.901e-05 |
75 |
0.0006404 |
71 |
Genes up-regulated in hepatic stellar cells after stimulation with bacterial lipopolysacharide (LPS). |
www.broad.mit.e...
|
Broad HAN_SATB1_TARGETS_DN |
View Gene Set
|
2.009e-05 |
320 |
0.0006673 |
72 |
Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [Gene ID=6304] by RNAi. |
www.broad.mit.e...
|
Broad ZHAN_MULTIPLE_MYELOMA_LB_DN |
View Gene Set
|
2.164e-05 |
43 |
0.0007092 |
73 |
Top 50 down-regulated genes in cluster LB of multiple myeloma samples belonging to the low bone disease group. |
www.broad.mit.e...
|
Broad ELVIDGE_HYPOXIA_UP |
View Gene Set
|
2.586e-05 |
163 |
0.0008359 |
74 |
Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. |
www.broad.mit.e...
|
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP |
View Gene Set
|
2.852e-05 |
65 |
0.0009097 |
75 |
Genes up-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. |
www.broad.mit.e...
|
Broad XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP |
View Gene Set
|
3.166e-05 |
14 |
0.0009966 |
76 |
Genes up-regulated synergistically in NB4 cells (acute promyelocytic leukemia
APL) by tretinoin and NSC682994 [PubChem=5538
388304].
|
www.broad.mit.e...
|
Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP |
View Gene Set
|
3.28e-05 |
75 |
0.001004 |
77 |
Up-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [Gene ID=4297
4299] or AF4-MLL fusion proteins alone
and those expressing both fusion proteins.
|
www.broad.mit.e...
|
Broad GRANDVAUX_IRF3_TARGETS_UP |
View Gene Set
|
3.274e-05 |
10 |
0.001004 |
77 |
Genes up-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [Gene ID=3661]. |
www.broad.mit.e...
|
Broad LIU_VAV3_PROSTATE_CARCINOGENESIS_UP |
View Gene Set
|
3.315e-05 |
89 |
0.001004 |
77 |
Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [Gene ID=10451] in prostate epithelium. |
www.broad.mit.e...
|
Broad CAIRO_HEPATOBLASTOMA_CLASSES_DN |
View Gene Set
|
3.827e-05 |
205 |
0.001144 |
80 |
Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). |
www.broad.mit.e...
|
Broad ZHOU_INFLAMMATORY_RESPONSE_LPS_UP |
View Gene Set
|
4.326e-05 |
400 |
0.001262 |
81 |
Genes up-regulated in macrophages by P.gingivalis LPS (lipopolysaccharide). |
www.broad.mit.e...
|
Broad NAGASHIMA_NRG1_SIGNALING_UP |
View Gene Set
|
4.296e-05 |
171 |
0.001262 |
81 |
Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [Gene ID=3084]. |
www.broad.mit.e...
|
Broad RODWELL_AGING_KIDNEY_UP |
View Gene Set
|
4.764e-05 |
326 |
0.001373 |
83 |
Genes whose expression increases with age in normal kidney. |
www.broad.mit.e...
|
Broad DER_IFN_GAMMA_RESPONSE_UP |
View Gene Set
|
4.889e-05 |
58 |
0.001392 |
84 |
Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h. |
www.broad.mit.e...
|
Broad VERHAAK_AML_WITH_NPM1_MUTATED_DN |
View Gene Set
|
4.983e-05 |
241 |
0.001402 |
85 |
Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [Gene ID=4869]. |
www.broad.mit.e...
|
Broad TSAI_RESPONSE_TO_RADIATION_THERAPY |
View Gene Set
|
5.182e-05 |
31 |
0.001441 |
86 |
Genes up-regulated in response to both single dose and fractionated radiation that were common to all three cell lines studied. |
www.broad.mit.e...
|
Broad DER_IFN_BETA_RESPONSE_UP |
View Gene Set
|
5.89e-05 |
82 |
0.001613 |
87 |
Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. |
www.broad.mit.e...
|
Broad WANG_SMARCE1_TARGETS_UP |
View Gene Set
|
5.932e-05 |
158 |
0.001613 |
87 |
Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [Gene ID=6605] off a retroviral vector. |
www.broad.mit.e...
|
Broad HOOI_ST7_TARGETS_DN |
View Gene Set
|
6.84e-05 |
108 |
0.001838 |
89 |
Genes down-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [Gene ID=7982] off a plasmid vector. |
www.broad.mit.e...
|
Broad PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP |
View Gene Set
|
7.308e-05 |
197 |
0.001942 |
90 |
Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. |
www.broad.mit.e...
|
Broad KONDO_EZH2_TARGETS |
View Gene Set
|
9.128e-05 |
142 |
0.002399 |
91 |
Genes up-regulated in PC3 cells (prostate cancer) after EZH2 [Gene ID=2146] knockdown by RNAi. |
www.broad.mit.e...
|
Broad TARTE_PLASMA_CELL_VS_PLASMABLAST_UP |
View Gene Set
|
9.638e-05 |
386 |
0.002506 |
92 |
Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. |
www.broad.mit.e...
|
Broad OKUMURA_INFLAMMATORY_RESPONSE_LPS |
View Gene Set
|
0.0001033 |
179 |
0.002657 |
93 |
Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS). |
www.broad.mit.e...
|
Broad WEST_ADRENOCORTICAL_TUMOR_DN |
View Gene Set
|
0.000106 |
531 |
0.002698 |
94 |
Down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. |
www.broad.mit.e...
|
Broad BLALOCK_ALZHEIMERS_DISEASE_UP |
View Gene Set
|
0.0001157 |
1641 |
0.002914 |
95 |
Genes up-regulated in brain from patients with Alzheimer's disease. |
www.broad.mit.e...
|
Broad MENSE_HYPOXIA_UP |
View Gene Set
|
0.0001233 |
94 |
0.003072 |
96 |
Hypoxia response genes in both astrocytes and HeLa cell line. |
www.broad.mit.e...
|
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 |
View Gene Set
|
0.0001261 |
64 |
0.003111 |
97 |
Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 6. |
www.broad.mit.e...
|
Broad FARMER_BREAST_CANCER_CLUSTER_1 |
View Gene Set
|
0.0001409 |
44 |
0.003404 |
98 |
Cluster 1: interferon
T and B lymphocyte genes clustered together across breast cancer samples.
|
www.broad.mit.e...
|
Broad DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN |
View Gene Set
|
0.0001397 |
28 |
0.003404 |
98 |
Genes down-regulated in fibroblasts expressing different mutant forms of ERCC3 [Gene ID=2071]: XP/CS (xeroderma pigmentosum (XP) and Cockraine's syndrome (CS)) vs TTD (trichothiodystrophy). |
www.broad.mit.e...
|
Broad ONDER_CDH1_TARGETS_2_UP |
View Gene Set
|
0.0001566 |
249 |
0.003746 |
100 |
Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. |
www.broad.mit.e...
|
Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP |
View Gene Set
|
0.0001858 |
783 |
0.004401 |
101 |
Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. |
www.broad.mit.e...
|
Broad HUTTMANN_B_CLL_POOR_SURVIVAL_DN |
View Gene Set
|
0.0002024 |
59 |
0.00474 |
102 |
Down-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [Gene ID=7535
952]
which are associated with poor survival.
|
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP |
View Gene Set
|
0.0002041 |
168 |
0.00474 |
102 |
Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 16 days after transduction.
|
www.broad.mit.e...
|
Broad TSAI_DNAJB4_TARGETS_UP |
View Gene Set
|
0.0002104 |
13 |
0.00484 |
104 |
Genes up-regulated in CL1-5 cells (lung cancer) overexpressing DNAJB4 [Gene ID=11080] off a plasmid vector. |
www.broad.mit.e...
|
Broad LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT |
View Gene Set
|
0.0002298 |
100 |
0.005235 |
105 |
Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF). |
www.broad.mit.e...
|
Broad SAGIV_CD24_TARGETS_DN |
View Gene Set
|
0.0002435 |
45 |
0.005495 |
106 |
Genes down-regulated in HT29 cells (colon cancer) after knockdown of CD24 [Gene ID=100133941] by both RNAi and monoclonal antibodies. |
www.broad.mit.e...
|
Broad ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP |
View Gene Set
|
0.0002532 |
78 |
0.00566 |
107 |
Genes up-regulated in P493-6 cells (B lymphocyte) by MYC [Gene ID=4609] and down-regulated by RNAi knockdown of TFRC [Gene ID=7037]. |
www.broad.mit.e...
|
Broad PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN |
View Gene Set
|
0.0002648 |
123 |
0.005864 |
108 |
Down-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. |
www.broad.mit.e...
|
Broad WEST_ADRENOCORTICAL_TUMOR_MARKERS_DN |
View Gene Set
|
0.0002817 |
20 |
0.006182 |
109 |
Top down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. |
www.broad.mit.e...
|
Broad RIGGI_EWING_SARCOMA_PROGENITOR_UP |
View Gene Set
|
0.0002877 |
399 |
0.006227 |
110 |
Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
2321] fusion protein.
|
www.broad.mit.e...
|
Broad HUANG_FOXA2_TARGETS_DN |
View Gene Set
|
0.0002889 |
36 |
0.006227 |
110 |
Genes down-regulated in H358 cells (lung cancer) by inducible expression of FOXA2 [GeneID=3170] in a Tet-off system. |
www.broad.mit.e...
|
Broad GILDEA_METASTASIS |
View Gene Set
|
0.0002916 |
29 |
0.006227 |
112 |
Top genes down-regulated in metastatic (T24T) vs non-metastatic (T24) bladder cancer cell lines. |
www.broad.mit.e...
|
Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP |
View Gene Set
|
0.0003007 |
74 |
0.006365 |
113 |
Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. |
www.broad.mit.e...
|
Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN |
View Gene Set
|
0.0003098 |
167 |
0.0065 |
114 |
Genes down-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [Gene ID=9260]
a latent gene of Epstein-Barr virus (EBV).
|
www.broad.mit.e...
|
Broad MANALO_HYPOXIA_UP |
View Gene Set
|
0.000317 |
197 |
0.006593 |
115 |
Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. |
www.broad.mit.e...
|
Broad ROZANOV_MMP14_TARGETS_UP |
View Gene Set
|
0.0003447 |
260 |
0.007107 |
116 |
Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [Gene ID=4323] compared to those with knockdown of the gene by RNAi. |
www.broad.mit.e...
|
Broad RIGGINS_TAMOXIFEN_RESISTANCE_DN |
View Gene Set
|
0.0003538 |
211 |
0.007233 |
117 |
Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug. |
www.broad.mit.e...
|
Broad LINDSTEDT_DENDRITIC_CELL_MATURATION_A |
View Gene Set
|
0.0003947 |
54 |
0.008 |
118 |
Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 8 hr after the stimulation (cluster A). |
www.broad.mit.e...
|
Broad MAHADEVAN_RESPONSE_TO_MP470_DN |
View Gene Set
|
0.0004062 |
16 |
0.008133 |
119 |
Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line sensitive to imatinib [PubChem=5291] after treatment with MP470
a protein kinase inhibitor.
|
www.broad.mit.e...
|
Broad BOYLAN_MULTIPLE_MYELOMA_C_D_DN |
View Gene Set
|
0.000408 |
232 |
0.008133 |
119 |
Genes down-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [Gene ID=598
4609] in plasma cells.
|
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN |
View Gene Set
|
0.0004169 |
192 |
0.008242 |
121 |
Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 8 days after transduction.
|
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_BASAL_DN |
View Gene Set
|
0.0004217 |
664 |
0.008267 |
122 |
Genes down-regulated in basal subtype of breast cancer samles. |
www.broad.mit.e...
|
Broad LIANG_SILENCED_BY_METHYLATION_UP |
View Gene Set
|
0.0004724 |
20 |
0.009186 |
123 |
Genes up-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. |
www.broad.mit.e...
|
Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN |
View Gene Set
|
0.0004932 |
485 |
0.009437 |
124 |
Genes down-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. |
www.broad.mit.e...
|
Broad UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN |
View Gene Set
|
0.0004913 |
37 |
0.009437 |
124 |
Genes up-regulated in HUVEC cells (primary endothelium) after stimulation with leukotriene LTD4 [PubChem=3908] or thrombin (F2) [Gene ID=2147] for 1 h. |
www.broad.mit.e...
|
Broad GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP |
View Gene Set
|
0.0005072 |
55 |
0.009628 |
126 |
Genes up-regulated in quescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of CML (chronic myeloblastic leukemia) patients compared to the dividing cells from normal donors. |
www.broad.mit.e...
|
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 |
View Gene Set
|
0.0005313 |
681 |
0.01001 |
127 |
The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
2064].
|
www.broad.mit.e...
|
Broad OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP |
View Gene Set
|
0.0006067 |
224 |
0.01118 |
128 |
Genes up-regulated in hematopoietic stem cells (HSC
CD34+ [Gene ID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension.
|
www.broad.mit.e...
|
Broad OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN |
View Gene Set
|
0.0006067 |
224 |
0.01118 |
128 |
Genes down-regulated in hematopoietic stem cells (HSC
CD34+ [Gene ID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension.
|
www.broad.mit.e...
|
Broad AMIT_EGF_RESPONSE_60_MCF10A |
View Gene Set
|
0.0006114 |
38 |
0.01118 |
128 |
Genes whose expression peaked at 60 min after stimulation of MCF10A cells with EGF [Gene ID=1950]. |
www.broad.mit.e...
|
Broad DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP |
View Gene Set
|
0.0006121 |
242 |
0.01118 |
128 |
Genes up-regulated in HEK293 cells (embryonic kidney) at 6 h
12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis).
|
www.broad.mit.e...
|
Broad RAY_TARGETS_OF_P210_BCR_ABL_FUSION_DN |
View Gene Set
|
0.0006496 |
13 |
0.01177 |
132 |
Genes down-regulated in HL-60 cells (acute myeloid leukemia
AML) by expression of p210 BCR-ABL [Gene ID=613
25] fusion protein.
|
www.broad.mit.e...
|
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 |
View Gene Set
|
0.000665 |
377 |
0.01196 |
133 |
The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
2064].
|
www.broad.mit.e...
|
Broad SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP |
View Gene Set
|
0.0006914 |
157 |
0.01216 |
134 |
Genes up-regulated in circulating endothelial cells (CEC) from cancer patients compared to those from healthy donors. |
www.broad.mit.e...
|
Broad ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN |
View Gene Set
|
0.0006903 |
100 |
0.01216 |
134 |
Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [Gene ID=3091
2034] by RNAi.
|
www.broad.mit.e...
|
Broad BECKER_TAMOXIFEN_RESISTANCE_DN |
View Gene Set
|
0.0006885 |
48 |
0.01216 |
134 |
Genes down-regulated in a breast cancer cell line resistant to tamoxifen [PubChem ID=5376] compared to the parental line sensitive to the drug. |
www.broad.mit.e...
|
Broad SENESE_HDAC1_AND_HDAC2_TARGETS_DN |
View Gene Set
|
0.0007335 |
218 |
0.01271 |
137 |
Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [Gene ID=3065
3066] by RNAi.
|
www.broad.mit.e...
|
Broad WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP |
View Gene Set
|
0.0007318 |
110 |
0.01271 |
137 |
Genes specific to esophageal adenocarcinoma (EAC) relative to normal tissue. |
www.broad.mit.e...
|
Broad RIGGI_EWING_SARCOMA_PROGENITOR_DN |
View Gene Set
|
0.0007872 |
178 |
0.01355 |
139 |
Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
2321] fusion protein.
|
www.broad.mit.e...
|
Broad LEE_DIFFERENTIATING_T_LYMPHOCYTE |
View Gene Set
|
0.0008363 |
129 |
0.01429 |
140 |
Genes enriched at every T lymphocyte differentiation stage compared to the early passage fetal thymic stromal cultures (TSC). |
www.broad.mit.e...
|
Broad LAIHO_COLORECTAL_CANCER_SERRATED_UP |
View Gene Set
|
0.0008445 |
108 |
0.01433 |
141 |
Genes up-regulated in serrated vs conventional colorectal carcinoma (CRC) samples. |
www.broad.mit.e...
|
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN |
View Gene Set
|
0.0008728 |
138 |
0.0144 |
142 |
Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928
3205] off a retroviral vector at 10 days after transduction.
|
www.broad.mit.e...
|
Broad CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP |
View Gene Set
|
0.0008694 |
228 |
0.0144 |
142 |
Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402]
a protease inhibitor causing apoptosis.
|
www.broad.mit.e...
|
Broad FOSTER_INFLAMMATORY_RESPONSE_LPS_DN |
View Gene Set
|
0.0008579 |
369 |
0.0144 |
142 |
Genes down-regulated by bacterial lipopolysaccharide (LPS) in non-tolerizeable (NT class) macrophages
compared to the ???tolerizeable??? (T class) ones.
|
www.broad.mit.e...
|
Broad RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP |
View Gene Set
|
0.0008614 |
394 |
0.0144 |
142 |
Genes up-regulated in peripheral blood mononucleocytes by HGF [Gene ID=3082] compared to those regulated by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. |
www.broad.mit.e...
|
Broad BILD_CTNNB1_ONCOGENIC_SIGNATURE |
View Gene Set
|
0.0009245 |
72 |
0.01515 |
146 |
Genes selected in supervised analyses to discriminate cells expressing activated beta-catenin (CTNNB1) [Gene ID=1499] oncogene from control cells expressing GFP. |
www.broad.mit.e...
|
Broad CHANG_IMMORTALIZED_BY_HPV31_DN |
View Gene Set
|
0.00096 |
47 |
0.01562 |
147 |
Genes down-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain. |
www.broad.mit.e...
|
Broad YANG_BREAST_CANCER_ESR1_DN |
View Gene Set
|
0.000979 |
19 |
0.01582 |
148 |
Genes down-regulated in early primary breast tumors expressing ESR1 [Gene ID=2099] vs the ESR1 negative ones. |
www.broad.mit.e...
|
Broad TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN |
View Gene Set
|
0.001027 |
186 |
0.01638 |
149 |
Genes down-regulated in ductal carcinoma vs normal ductal breast cells. |
www.broad.mit.e...
|
Broad SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 |
View Gene Set
|
0.001023 |
407 |
0.01638 |
149 |
Genes up-regulated in the pancreatic cancer cell lines (AsPC1
Hs766T
MiaPaCa2
Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].
|
www.broad.mit.e...
|
Broad RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN |
View Gene Set
|
0.001039 |
301 |
0.01645 |
151 |
Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. |
www.broad.mit.e...
|
Broad CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN |
View Gene Set
|
0.001132 |
36 |
0.01782 |
152 |
Selected genes down-regulated during invasion of lymphatic vessels during metastasis. |
www.broad.mit.e...
|
Broad GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP |
View Gene Set
|
0.001154 |
38 |
0.01802 |
153 |
Genes up-regulated in common hematopoietic progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [Gene ID=6223]. |
www.broad.mit.e...
|
Broad SABATES_COLORECTAL_ADENOMA_DN |
View Gene Set
|
0.00116 |
276 |
0.01802 |
153 |
Genes down-regulated in colorectal adenoma compared to normal mucosa samples. |
www.broad.mit.e...
|
Broad ONDER_CDH1_TARGETS_2_DN |
View Gene Set
|
0.001196 |
453 |
0.01846 |
155 |
Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. |
www.broad.mit.e...
|
Broad HAMAI_APOPTOSIS_VIA_TRAIL_UP |
View Gene Set
|
0.001211 |
328 |
0.01851 |
156 |
Genes up-regulated in T1 cells (primary melanoma
sensitive to TRAIL [Gene ID=8743]) compared to G1 cells (metastatic melanoma
resistant to TRAIL).
|
www.broad.mit.e...
|
Broad DAUER_STAT3_TARGETS_UP |
View Gene Set
|
0.001215 |
39 |
0.01851 |
156 |
Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [Gene ID=6774] off an adenovirus vector. |
www.broad.mit.e...
|
Broad AMIT_EGF_RESPONSE_60_HELA |
View Gene Set
|
0.001269 |
43 |
0.01921 |
158 |
Genes whose expression peaked at 60 min after stimulation of HeLa cells with EGF [Gene ID=1950]. |
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN |
View Gene Set
|
0.001302 |
444 |
0.01959 |
159 |
Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. |
www.broad.mit.e...
|
Broad GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP |
View Gene Set
|
0.001412 |
23 |
0.02104 |
160 |
Genes up-regulated in quiescent (G0) vs dividing (M) CD34+ [Gene ID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients. |
www.broad.mit.e...
|
Broad PEREZ_TP63_TARGETS |
View Gene Set
|
0.001416 |
328 |
0.02104 |
160 |
Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vector. |
www.broad.mit.e...
|
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP |
View Gene Set
|
0.001462 |
716 |
0.02159 |
162 |
Genes up-regulated in HL-60 cells (acute promyelocytic leukemia
APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h.
|
www.broad.mit.e...
|
Broad ALONSO_METASTASIS_NEURAL_UP |
View Gene Set
|
0.001538 |
16 |
0.02257 |
163 |
Neural-related genes up-regulated in melanoma tumors that developed metastases compared to primary melanoma that did not. |
www.broad.mit.e...
|
Broad TSUNODA_CISPLATIN_RESISTANCE_DN |
View Gene Set
|
0.001552 |
28 |
0.02264 |
164 |
Genes down-regulated in bladder cancer cells resistant to cisplatin [PubChem=2767] compared to the parental cells sensitive to the drug. |
www.broad.mit.e...
|
Broad ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN |
View Gene Set
|
0.001567 |
262 |
0.02272 |
165 |
Genes down-regulated in liver tumor compared to the normal adjacent tissue. |
www.broad.mit.e...
|
Broad CERVERA_SDHB_TARGETS_1_UP |
View Gene Set
|
0.001597 |
110 |
0.02296 |
166 |
Genes turned on in Hep3B cells (hepatocellular carcinoma
HCC) upon knockdown of SDHB [Gene ID=6390] by RNAi.
|
www.broad.mit.e...
|
Broad PALOMERO_GSI_SENSITIVITY_DN |
View Gene Set
|
0.001603 |
5 |
0.02296 |
166 |
Down-regulated genes associated with sensitivity and resistance to gamma-secretase (GSI) in T-cell acute lymphoblastic leukemia (T-ALL) cell lines. |
www.broad.mit.e...
|
Broad KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP |
View Gene Set
|
0.001673 |
126 |
0.02381 |
168 |
Genes up-regulated in glioma cell lines treated with both decitabine [PubChem=451668] and TSA [PubChem=5562]. |
www.broad.mit.e...
|
Broad BILBAN_B_CLL_LPL_DN |
View Gene Set
|
0.001725 |
39 |
0.02439 |
169 |
Genes down-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [Gene ID=4023] compared with those expressing low levels of the gene. |
www.broad.mit.e...
|
Broad HUPER_BREAST_BASAL_VS_LUMINAL_UP |
View Gene Set
|
0.001733 |
54 |
0.02439 |
169 |
Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. |
www.broad.mit.e...
|
Broad CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP |
View Gene Set
|
0.001798 |
165 |
0.02498 |
171 |
Genes up-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [Gene ID=5371
5914] compared to normal promyeloblasts.
|
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN |
View Gene Set
|
0.001806 |
26 |
0.02498 |
171 |
Genes down-regulated in pleura relapse of breast cancer. |
www.broad.mit.e...
|
Broad BROWNE_HCMV_INFECTION_20HR_DN |
View Gene Set
|
0.001789 |
107 |
0.02498 |
171 |
Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 20 h time point that were not down-regulated at the previous time point
18 h.
|
www.broad.mit.e...
|
Broad NIELSEN_SYNOVIAL_SARCOMA_DN |
View Gene Set
|
0.001839 |
8 |
0.02529 |
174 |
Top 20 negative significant genes associated with synovial sarcoma tumors. |
www.broad.mit.e...
|
Broad NOJIMA_SFRP2_TARGETS_UP |
View Gene Set
|
0.001883 |
30 |
0.02574 |
175 |
Cellular proliferation
growth
apoptosis and Wnt signaling genes up-regulated in SNU638 cells (gastric cancer) by overexpression of SFRP2 [Gene ID=6423] off a plasmid vector.
|
www.broad.mit.e...
|
Broad CHEN_HOXA5_TARGETS_6HR_UP |
View Gene Set
|
0.001925 |
10 |
0.02616 |
176 |
Differentially expressed genes 6 hr after tinduction of HoxA5 [Gene ID=3205] expression in a breast cancer cell line. |
www.broad.mit.e...
|
Broad ROY_WOUND_BLOOD_VESSEL_DN |
View Gene Set
|
0.001963 |
21 |
0.02653 |
177 |
Genes down-regulated in blood vessel cells from wound site. |
www.broad.mit.e...
|
Broad ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP |
View Gene Set
|
0.00203 |
458 |
0.02728 |
178 |
Genes up-regulated in macrophage by live P.gingivalis. |
www.broad.mit.e...
|
Broad JAATINEN_HEMATOPOIETIC_STEM_CELL_DN |
View Gene Set
|
0.00205 |
215 |
0.0274 |
179 |
Genes up-regulated in CD133+ [Gene ID=8842] cells (hematopoietic stem cells
HSC) compared to the CD133- cells.
|
www.broad.mit.e...
|
Broad ISHIKAWA_STING_SIGNALING |
View Gene Set
|
0.002106 |
9 |
0.02799 |
180 |
Prmary innate immune response genes induced in 293T cells (embryonic kidney) by overexpression of STING (TMEM173) [Gene ID=340061]. |
www.broad.mit.e...
|
Broad BENPORATH_ES_WITH_H3K27ME3 |
View Gene Set
|
0.002212 |
1094 |
0.02924 |
181 |
Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells
as identified by ChIP on chip.
|
www.broad.mit.e...
|
Broad LUI_THYROID_CANCER_CLUSTER_4 |
View Gene Set
|
0.002259 |
14 |
0.02969 |
182 |
Cluster 4: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples. |
www.broad.mit.e...
|
Broad DORSAM_HOXA9_TARGETS_UP |
View Gene Set
|
0.002376 |
31 |
0.03106 |
183 |
HOXA9 [Gene ID=3205] targets up-regulated in hematopoietic stem cells. |
www.broad.mit.e...
|
Broad GERY_CEBP_TARGETS |
View Gene Set
|
0.002452 |
115 |
0.03188 |
184 |
Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA
CEBPB
CEBPG
and CEBPD [Gene ID=1050
1051
1054
1052].
|
www.broad.mit.e...
|
Broad GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP |
View Gene Set
|
0.002488 |
24 |
0.03217 |
185 |
Genes up-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [Gene ID=6223]. |
www.broad.mit.e...
|
Broad WANG_HCP_PROSTATE_CANCER |
View Gene Set
|
0.002507 |
82 |
0.03224 |
186 |
Genes with the high-CpG-density promoters (HCP) that were up-regulated in 1542-CP3TX cells (prostate cancer) compared to 1542-NPTX (normal prostate). |
www.broad.mit.e...
|
Broad SOUCEK_MYC_TARGETS |
View Gene Set
|
0.002576 |
10 |
0.03295 |
187 |
Chemokine genes up-regulated within 2 hr of c-Myc [Gene ID=4609] activation in a mouse model of Myc-induced pancreatic beta-cell tumorigenesis. |
www.broad.mit.e...
|
Broad KYNG_DNA_DAMAGE_UP |
View Gene Set
|
0.002629 |
100 |
0.03345 |
188 |
Genes changed after DNA damage in cell lines from young donors
and that had a GO annotation.
|
www.broad.mit.e...
|
Broad COWLING_MYCN_TARGETS |
View Gene Set
|
0.002646 |
41 |
0.03346 |
189 |
Genes down-regulated by MYCN [Gene ID=4613] but not by its transactivation-defficient
trunkated form N-Myc-delta-73.
|
www.broad.mit.e...
|
Broad BROCKE_APOPTOSIS_REVERSED_BY_IL6 |
View Gene Set
|
0.002658 |
140 |
0.03346 |
189 |
Genes changed in INA-6 cells (multiple myeloma
MM) by re-addition of IL6 [Gene ID=3569] after its initial withdrawal for 12h.
|
www.broad.mit.e...
|
Broad SENESE_HDAC2_TARGETS_DN |
View Gene Set
|
0.002703 |
124 |
0.03385 |
191 |
Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [Gene ID=3066] by RNAi. |
www.broad.mit.e...
|
Broad MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN |
View Gene Set
|
0.002856 |
64 |
0.03558 |
192 |
Down-regulated 'cooperation response genes': responded synergystically to the combination of mutant TP53 [Gene ID=7157] and HRAS [Gene ID=3265] in YAMC cells (colon). |
www.broad.mit.e...
|
Broad KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN |
View Gene Set
|
0.002875 |
306 |
0.03564 |
193 |
Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) upon knockdown of the EWSR1-FLII fusion [Gene ID=2130
2314].
|
www.broad.mit.e...
|
Broad MUELLER_METHYLATED_IN_GLIOBLASTOMA |
View Gene Set
|
0.003002 |
42 |
0.03702 |
194 |
Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment. |
www.broad.mit.e...
|
Broad RUTELLA_RESPONSE_TO_HGF_UP |
View Gene Set
|
0.003027 |
409 |
0.03713 |
195 |
Genes up-regulated in peripheral blood monocytes by HGF [Gene ID=3082]. |
www.broad.mit.e...
|
Broad SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 |
View Gene Set
|
0.003133 |
48 |
0.03823 |
196 |
50 most interesting genes up-regulated in the pancreatic cancer cell lines (AsPC1
Hs766T
MiaPaCa2
Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].
|
www.broad.mit.e...
|
Broad LINDSTEDT_DENDRITIC_CELL_MATURATION_B |
View Gene Set
|
0.003221 |
47 |
0.03911 |
197 |
Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated both at 8 hr and 48 hr after the stimulation (cluster B). |
www.broad.mit.e...
|
Broad LIU_SOX4_TARGETS_UP |
View Gene Set
|
0.003346 |
131 |
0.03986 |
198 |
Genes up-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [Gene ID=6659] and down-regulated by its RNAi knockdown. |
www.broad.mit.e...
|
Broad THUM_SYSTOLIC_HEART_FAILURE_DN |
View Gene Set
|
0.003338 |
221 |
0.03986 |
198 |
Genes down-regulated in samples with systolic heart failure compared to normal hearts. |
www.broad.mit.e...
|
Broad KHETCHOUMIAN_TRIM24_TARGETS_UP |
View Gene Set
|
0.003335 |
45 |
0.03986 |
198 |
Retinoic acid-responsive genes up-regulated in hepatocellular carcinoma (HCC) samples of TRIM24 [Gene ID=8805] knockout mice. |
www.broad.mit.e...
|