Results

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AFA results for: miR.27bvsControl.ls

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Gene Set Collection: KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
KEGG 04060 View Gene Set 7.065e-05 266 0.01512 1 Cytokine-cytokine receptor interaction www.genome.jp/d...

Gene Set Collection: GO

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
GO GO:0006955 View Gene Set 3.028e-10 732 4.045e-06 1 immune response amigo.geneontol...
GO GO:0002376 View Gene Set 1.848e-08 1101 0.0001234 2 immune system process amigo.geneontol...
GO GO:0006952 View Gene Set 5.91e-07 717 0.001974 3 defense response amigo.geneontol...
GO GO:0032101 View Gene Set 4.889e-07 190 0.001974 3 regulation of response to external stimulus amigo.geneontol...
GO GO:0009611 View Gene Set 2.383e-06 621 0.006368 5 response to wounding amigo.geneontol...
GO GO:0005576 View Gene Set 5.052e-06 2036 0.01125 6 extracellular region amigo.geneontol...
GO GO:0002474 View Gene Set 7.059e-06 18 0.01347 7 antigen processing and presentation of peptide antigen via MHC class I amigo.geneontol...
GO GO:0051707 View Gene Set 9.105e-06 384 0.01521 8 response to other organism amigo.geneontol...
GO GO:0032103 View Gene Set 1.457e-05 88 0.01822 9 positive regulation of response to external stimulus amigo.geneontol...
GO GO:0048002 View Gene Set 1.749e-05 27 0.01822 9 antigen processing and presentation of peptide antigen amigo.geneontol...
GO GO:0044421 View Gene Set 1.773e-05 1001 0.01822 9 extracellular region part amigo.geneontol...
GO GO:0004888 View Gene Set 1.751e-05 1275 0.01822 9 transmembrane receptor activity amigo.geneontol...
GO GO:0005548 View Gene Set 1.357e-05 29 0.01822 9 phospholipid transporter activity amigo.geneontol...
GO GO:0050795 View Gene Set 2.008e-05 69 0.01916 14 regulation of behavior amigo.geneontol...
GO GO:0040012 View Gene Set 3.483e-05 246 0.03102 15 regulation of locomotion amigo.geneontol...
GO GO:0050920 View Gene Set 5.177e-05 51 0.04068 16 regulation of chemotaxis amigo.geneontol...
GO GO:0005615 View Gene Set 5.087e-05 752 0.04068 16 extracellular space amigo.geneontol...

Gene Set Collection: Broad.c1.CYTOBAND

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad chr6q14 View Gene Set 9.61e-05 42 0.03133 1 Genes in cytogenetic band chr6q14 www.broad.mit.e...

Gene Set Collection: Broad.c2.CGP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad BROWNE_INTERFERON_RESPONSIVE_GENES View Gene Set 3.134e-22 67 7.496e-19 1 Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h. www.broad.mit.e...
Broad MOSERLE_IFNA_RESPONSE View Gene Set 3.659e-18 30 4.377e-15 2 Top 50 genes up-regulated in ovarian cancer progenitor cells (also known as side population SP cells) in response to interferon alpha (IFNA). www.broad.mit.e...
Broad WALLACE_PROSTATE_CANCER_RACE_UP View Gene Set 8.422e-16 288 6.715e-13 3 Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. www.broad.mit.e...
Broad FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN View Gene Set 4.395e-14 431 2.628e-11 4 Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin LGALS1) [Gene ID=3956] compared to that with bacterial lipopolysaccharide (LPS). www.broad.mit.e...
Broad NUYTTEN_EZH2_TARGETS_UP View Gene Set 6.216e-14 944 2.854e-11 5 Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. www.broad.mit.e...
Broad SANA_TNF_SIGNALING_UP View Gene Set 7.159e-14 75 2.854e-11 5 Genes up-regulated in five primary endothelial cell types (lung aortic iliac dermal and colon) by TNF [Gene ID=7124]. www.broad.mit.e...
Broad SANA_RESPONSE_TO_IFNG_UP View Gene Set 1.173e-13 68 4.007e-11 7 Genes up-regulated in five primary endothelial cell types (lung aortic iliac dermal and colon) by IFNG [Gene ID=3458]. www.broad.mit.e...
Broad SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP View Gene Set 1.871e-13 72 5.594e-11 8 Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p). www.broad.mit.e...
Broad DAUER_STAT3_TARGETS_DN View Gene Set 2.853e-12 37 7.582e-10 9 Top 50 genes down-regulated in A549 cells (lung cancer) expressing STAT3 [Gene ID=6774] off an adenovirus vector. www.broad.mit.e...
Broad ZHANG_INTERFERON_RESPONSE View Gene Set 4.322e-12 21 1.034e-09 10 Interferon-inducible genes up-regulated in A549 cells (lung cancer) infected with a respiratory syncytial virus (RSV) that had its NS1 [Gene ID=1494468] gene knocked down by RNAi. www.broad.mit.e...
Broad HORIUCHI_WTAP_TARGETS_UP View Gene Set 1.067e-11 284 2.321e-09 11 Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. www.broad.mit.e...
Broad ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP View Gene Set 1.148e-10 208 2.288e-08 12 Genes up-regulated in BxPC3 cells (pancreatic cancer) after treatment with TNF [Gene ID=7124] or IKI-1 an inhibitor of I?B kinase (IKK). www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP View Gene Set 1.34e-10 174 2.466e-08 13 Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 3 days after transduction. www.broad.mit.e...
Broad CHEN_HOXA5_TARGETS_9HR_UP View Gene Set 1.56e-10 210 2.665e-08 14 Differentially expressed genes 9 hr after tinduction of HoxA5 [Gene ID=3205] expression in a breast cancer cell line. www.broad.mit.e...
Broad BOWIE_RESPONSE_TO_TAMOXIFEN View Gene Set 2.605e-10 14 4.154e-08 15 Genes up-regulated by tamoxifen [PubChem=5376] in HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]). www.broad.mit.e...
Broad SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP View Gene Set 2.942e-10 339 4.398e-08 16 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS non-invasive). www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP View Gene Set 6.674e-10 186 9.084e-08 17 Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 10 days after transduction. www.broad.mit.e...
Broad MITSIADES_RESPONSE_TO_APLIDIN_UP View Gene Set 6.836e-10 413 9.084e-08 17 Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164] a marine-derived compound with potential anti-cancer properties. www.broad.mit.e...
Broad LIU_COMMON_CANCER_GENES View Gene Set 2.215e-09 43 2.789e-07 19 Low abundance transcripts common to nasopharyngeal carcinoma (NPC) breast and liver tumors. www.broad.mit.e...
Broad NUYTTEN_NIPP1_TARGETS_UP View Gene Set 3.083e-09 657 3.512e-07 20 Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. www.broad.mit.e...
Broad KIM_LRRC3B_TARGETS View Gene Set 2.973e-09 30 3.512e-07 20 Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135]. www.broad.mit.e...
Broad KERLEY_RESPONSE_TO_CISPLATIN_UP View Gene Set 4.175e-09 38 4.539e-07 22 Genes genes up-regulated in NT2/D1 cells (embryonal carcinoma) in response to treatment with cisplatin [PubChem=2767]. www.broad.mit.e...
Broad BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS View Gene Set 4.623e-09 23 4.808e-07 23 Genes significantly up-regulated in the blood mononuclear cells from patients with systemic lupus erythematosus compared to those from healthy persons. www.broad.mit.e...
Broad UROSEVIC_RESPONSE_TO_IMIQUIMOD View Gene Set 6.669e-09 16 6.647e-07 24 Interferon cluster genes up-regulated in skin tumors treated with imiquimod [PubChem=57469]. www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN View Gene Set 8.375e-09 133 8.013e-07 25 Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 16 days after transduction. www.broad.mit.e...
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN View Gene Set 1.008e-08 437 9.276e-07 26 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. www.broad.mit.e...
Broad SMID_BREAST_CANCER_NORMAL_LIKE_UP View Gene Set 1.088e-08 459 9.641e-07 27 Genes up-regulated in the normal-like subtype of breast cancer. www.broad.mit.e...
Broad DER_IFN_ALPHA_RESPONSE_UP View Gene Set 2.779e-08 57 2.374e-06 28 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. www.broad.mit.e...
Broad GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3 View Gene Set 3.178e-08 11 2.621e-06 29 Genes up-regulated in Jurkat cells (T lymphocyte) by IFN1@ and IFNB1 [Gene ID=3438 3456] but not by overexpression of a constitutively active form of IRF3 [Gene ID=3661]. www.broad.mit.e...
Broad LIU_PROSTATE_CANCER_DN View Gene Set 4.295e-08 446 3.425e-06 30 Genes down-regulated in prostate cancer samples. www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP View Gene Set 5.201e-08 153 4.013e-06 31 Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 8 days after transduction. www.broad.mit.e...
Broad DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN View Gene Set 6.791e-08 303 5.076e-06 32 Genes down-regulated in T-PLL cells (T-cell prolymphocytic leukemia) bearing the inv(14)/t(14:14) chromosomal aberration. www.broad.mit.e...
Broad BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX View Gene Set 1.202e-07 10 8.714e-06 33 Genes up-regulated by growing HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [Gene ID=1489078]) in extracellular matrix (ECM). www.broad.mit.e...
Broad PRAMOONJAGO_SOX4_TARGETS_UP View Gene Set 1.391e-07 49 9.789e-06 34 Genes up-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [Gene ID=6659] by RNAi. www.broad.mit.e...
Broad PEREZ_TP53_TARGETS View Gene Set 1.467e-07 1066 1.002e-05 35 Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [Gene ID=7157] off adenoviral vector. www.broad.mit.e...
Broad WIELAND_UP_BY_HBV_INFECTION View Gene Set 1.853e-07 98 1.232e-05 36 Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees. www.broad.mit.e...
Broad MCLACHLAN_DENTAL_CARIES_DN View Gene Set 2.751e-07 234 1.778e-05 37 Genes down-regulated in pulpal tissue extracted from carious teeth. www.broad.mit.e...
Broad ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP View Gene Set 3.586e-07 93 2.257e-05 38 Hepatic graft versus host disease (GVHD) day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant. www.broad.mit.e...
Broad FUJII_YBX1_TARGETS_UP View Gene Set 4.161e-07 27 2.552e-05 39 Genes up-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [Gene ID=4904] by RNAi. www.broad.mit.e...
Broad BASSO_HAIRY_CELL_LEUKEMIA_DN View Gene Set 4.793e-07 78 2.866e-05 40 Genes down-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations. www.broad.mit.e...
Broad ZHU_CMV_8_HR_UP View Gene Set 5.018e-07 32 2.927e-05 41 Up-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV www.broad.mit.e...
Broad PODAR_RESPONSE_TO_ADAPHOSTIN_UP View Gene Set 5.702e-07 140 3.248e-05 42 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042] a tyrosine kinase inhibitor with anticancer properties. www.broad.mit.e...
Broad KRASNOSELSKAYA_ILF3_TARGETS_UP View Gene Set 7.299e-07 31 4.06e-05 43 Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [Gene ID=3609]. www.broad.mit.e...
Broad EINAV_INTERFERON_SIGNATURE_IN_CANCER View Gene Set 7.661e-07 27 4.165e-05 44 A gene expression signature found in a subset of cancer patients suggestive of a deregulated immune or inflammatory response. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN View Gene Set 1.083e-06 732 5.755e-05 45 Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. www.broad.mit.e...
Broad GOZGIT_ESR1_TARGETS_DN View Gene Set 1.31e-06 710 6.666e-05 46 Genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [Gene ID=2099]) compared to the parental MCF7 cells which do. www.broad.mit.e...
Broad LIANG_SILENCED_BY_METHYLATION_2 View Gene Set 1.29e-06 35 6.666e-05 46 Genes up-regulated in T24 cells (bladder carcinoma) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. www.broad.mit.e...
Broad YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP View Gene Set 1.488e-06 130 7.414e-05 48 Genes up-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag a hedgehog (Hh) pathway inhibitor. www.broad.mit.e...
Broad MAHADEVAN_RESPONSE_TO_MP470_UP View Gene Set 1.526e-06 19 7.448e-05 49 Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] after treatment with MP470 a protein kinase inhibitor. www.broad.mit.e...
Broad RADAEVA_RESPONSE_TO_IFNA1_UP View Gene Set 1.616e-06 32 7.733e-05 50 Genes up-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [Gene ID=3439]. www.broad.mit.e...
Broad SMID_BREAST_CANCER_LUMINAL_B_DN View Gene Set 1.702e-06 549 7.982e-05 51 Genes down-regulated in the luminal B subtype of breast cancer. www.broad.mit.e...
Broad LEE_NEURAL_CREST_STEM_CELL_DN View Gene Set 3.059e-06 114 0.0001407 52 Genes down-regulated in the neural crest stem cells (NCS) defined as p75+/HNK1+ [Gene ID=4804 27087]. www.broad.mit.e...
Broad HELLER_SILENCED_BY_METHYLATION_UP View Gene Set 4.268e-06 247 0.0001926 53 Genes up-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. www.broad.mit.e...
Broad VECCHI_GASTRIC_CANCER_EARLY_DN View Gene Set 4.567e-06 346 0.0002017 54 Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. www.broad.mit.e...
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_UP View Gene Set 4.638e-06 99 0.0002017 54 Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668] a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. www.broad.mit.e...
Broad SPIRA_SMOKERS_LUNG_CANCER_DN View Gene Set 4.88e-06 20 0.0002084 56 Down-regulated genes that distinguished smokers with and without lung cancer. www.broad.mit.e...
Broad RUIZ_TNC_TARGETS_UP View Gene Set 4.991e-06 145 0.0002094 57 Genes up-regulated in T98G cells (glioblastoma) by TNC [Gene ID=3371]. www.broad.mit.e...
Broad MCLACHLAN_DENTAL_CARIES_UP View Gene Set 6.121e-06 207 0.0002524 58 Genes up-regulated in pulpal tissue extracted from carious teeth. www.broad.mit.e...
Broad ELVIDGE_HYPOXIA_BY_DMOG_UP View Gene Set 6.442e-06 125 0.0002612 59 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. www.broad.mit.e...
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN View Gene Set 6.991e-06 93 0.0002787 60 Genes down-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. www.broad.mit.e...
Broad SCHAVOLT_TARGETS_OF_TP53_AND_TP63 View Gene Set 7.961e-06 16 0.0003102 61 Genes up-regulated by TP53 [Gene ID=7157] and down-regulated by an isoform of TP63 [Gene ID=8626] in primary HEK cells (epidermal keratinocytes). www.broad.mit.e...
Broad HINATA_NFKB_TARGETS_KERATINOCYTE_UP View Gene Set 8.041e-06 71 0.0003102 61 Genes up-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [Gene ID=4790 5970] components of NFKB. www.broad.mit.e...
Broad UDAYAKUMAR_MED1_TARGETS_DN View Gene Set 8.954e-06 230 0.0003347 63 Genes down-regulated in HeLa cells after knockdown of MED1 [Gene ID=5469] by RNAi. www.broad.mit.e...
Broad ROETH_TERT_TARGETS_UP View Gene Set 8.822e-06 8 0.0003347 63 Genes up-regulated in T lymphocytes overexpressing TERT [Gene ID=7015] off a retrovirus vector. www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_2B View Gene Set 9.681e-06 384 0.0003562 65 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. www.broad.mit.e...
Broad MARKEY_RB1_ACUTE_LOF_UP View Gene Set 1.298e-05 202 0.0004705 66 Genes up-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. www.broad.mit.e...
Broad GEISS_RESPONSE_TO_DSRNA_UP View Gene Set 1.353e-05 32 0.0004829 67 Genes up-pregulated by dsRNA in GRE cells (glioma; no interferon system). www.broad.mit.e...
Broad LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP View Gene Set 1.573e-05 178 0.0005535 68 Genes up-regulated in Wilm's tumor samples compared to fetal kidney. www.broad.mit.e...
Broad GAURNIER_PSMD4_TARGETS View Gene Set 1.712e-05 59 0.0005936 69 Inflammatory cytokines chemokines and their cognate receptors up-regulated in THP-1 cells (monocyte) after treatment with PSMD4 [Gene ID=5710]. www.broad.mit.e...
Broad FRIDMAN_IMMORTALIZATION_DN View Gene Set 1.803e-05 32 0.0006163 70 Genes down-regulated in immortalized cell lines. www.broad.mit.e...
Broad SEKI_INFLAMMATORY_RESPONSE_LPS_UP View Gene Set 1.901e-05 75 0.0006404 71 Genes up-regulated in hepatic stellar cells after stimulation with bacterial lipopolysacharide (LPS). www.broad.mit.e...
Broad HAN_SATB1_TARGETS_DN View Gene Set 2.009e-05 320 0.0006673 72 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [Gene ID=6304] by RNAi. www.broad.mit.e...
Broad ZHAN_MULTIPLE_MYELOMA_LB_DN View Gene Set 2.164e-05 43 0.0007092 73 Top 50 down-regulated genes in cluster LB of multiple myeloma samples belonging to the low bone disease group. www.broad.mit.e...
Broad ELVIDGE_HYPOXIA_UP View Gene Set 2.586e-05 163 0.0008359 74 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. www.broad.mit.e...
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP View Gene Set 2.852e-05 65 0.0009097 75 Genes up-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. www.broad.mit.e...
Broad XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP View Gene Set 3.166e-05 14 0.0009966 76 Genes up-regulated synergistically in NB4 cells (acute promyelocytic leukemia APL) by tretinoin and NSC682994 [PubChem=5538 388304]. www.broad.mit.e...
Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP View Gene Set 3.28e-05 75 0.001004 77 Up-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [Gene ID=4297 4299] or AF4-MLL fusion proteins alone and those expressing both fusion proteins. www.broad.mit.e...
Broad GRANDVAUX_IRF3_TARGETS_UP View Gene Set 3.274e-05 10 0.001004 77 Genes up-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [Gene ID=3661]. www.broad.mit.e...
Broad LIU_VAV3_PROSTATE_CARCINOGENESIS_UP View Gene Set 3.315e-05 89 0.001004 77 Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [Gene ID=10451] in prostate epithelium. www.broad.mit.e...
Broad CAIRO_HEPATOBLASTOMA_CLASSES_DN View Gene Set 3.827e-05 205 0.001144 80 Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). www.broad.mit.e...
Broad ZHOU_INFLAMMATORY_RESPONSE_LPS_UP View Gene Set 4.326e-05 400 0.001262 81 Genes up-regulated in macrophages by P.gingivalis LPS (lipopolysaccharide). www.broad.mit.e...
Broad NAGASHIMA_NRG1_SIGNALING_UP View Gene Set 4.296e-05 171 0.001262 81 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [Gene ID=3084]. www.broad.mit.e...
Broad RODWELL_AGING_KIDNEY_UP View Gene Set 4.764e-05 326 0.001373 83 Genes whose expression increases with age in normal kidney. www.broad.mit.e...
Broad DER_IFN_GAMMA_RESPONSE_UP View Gene Set 4.889e-05 58 0.001392 84 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h. www.broad.mit.e...
Broad VERHAAK_AML_WITH_NPM1_MUTATED_DN View Gene Set 4.983e-05 241 0.001402 85 Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [Gene ID=4869]. www.broad.mit.e...
Broad TSAI_RESPONSE_TO_RADIATION_THERAPY View Gene Set 5.182e-05 31 0.001441 86 Genes up-regulated in response to both single dose and fractionated radiation that were common to all three cell lines studied. www.broad.mit.e...
Broad DER_IFN_BETA_RESPONSE_UP View Gene Set 5.89e-05 82 0.001613 87 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. www.broad.mit.e...
Broad WANG_SMARCE1_TARGETS_UP View Gene Set 5.932e-05 158 0.001613 87 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [Gene ID=6605] off a retroviral vector. www.broad.mit.e...
Broad HOOI_ST7_TARGETS_DN View Gene Set 6.84e-05 108 0.001838 89 Genes down-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [Gene ID=7982] off a plasmid vector. www.broad.mit.e...
Broad PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP View Gene Set 7.308e-05 197 0.001942 90 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. www.broad.mit.e...
Broad KONDO_EZH2_TARGETS View Gene Set 9.128e-05 142 0.002399 91 Genes up-regulated in PC3 cells (prostate cancer) after EZH2 [Gene ID=2146] knockdown by RNAi. www.broad.mit.e...
Broad TARTE_PLASMA_CELL_VS_PLASMABLAST_UP View Gene Set 9.638e-05 386 0.002506 92 Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. www.broad.mit.e...
Broad OKUMURA_INFLAMMATORY_RESPONSE_LPS View Gene Set 0.0001033 179 0.002657 93 Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS). www.broad.mit.e...
Broad WEST_ADRENOCORTICAL_TUMOR_DN View Gene Set 0.000106 531 0.002698 94 Down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_UP View Gene Set 0.0001157 1641 0.002914 95 Genes up-regulated in brain from patients with Alzheimer's disease. www.broad.mit.e...
Broad MENSE_HYPOXIA_UP View Gene Set 0.0001233 94 0.003072 96 Hypoxia response genes in both astrocytes and HeLa cell line. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 View Gene Set 0.0001261 64 0.003111 97 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 6. www.broad.mit.e...
Broad FARMER_BREAST_CANCER_CLUSTER_1 View Gene Set 0.0001409 44 0.003404 98 Cluster 1: interferon T and B lymphocyte genes clustered together across breast cancer samples. www.broad.mit.e...
Broad DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN View Gene Set 0.0001397 28 0.003404 98 Genes down-regulated in fibroblasts expressing different mutant forms of ERCC3 [Gene ID=2071]: XP/CS (xeroderma pigmentosum (XP) and Cockraine's syndrome (CS)) vs TTD (trichothiodystrophy). www.broad.mit.e...
Broad ONDER_CDH1_TARGETS_2_UP View Gene Set 0.0001566 249 0.003746 100 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. www.broad.mit.e...
Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP View Gene Set 0.0001858 783 0.004401 101 Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. www.broad.mit.e...
Broad HUTTMANN_B_CLL_POOR_SURVIVAL_DN View Gene Set 0.0002024 59 0.00474 102 Down-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [Gene ID=7535 952] which are associated with poor survival. www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP View Gene Set 0.0002041 168 0.00474 102 Genes up-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 16 days after transduction. www.broad.mit.e...
Broad TSAI_DNAJB4_TARGETS_UP View Gene Set 0.0002104 13 0.00484 104 Genes up-regulated in CL1-5 cells (lung cancer) overexpressing DNAJB4 [Gene ID=11080] off a plasmid vector. www.broad.mit.e...
Broad LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT View Gene Set 0.0002298 100 0.005235 105 Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF). www.broad.mit.e...
Broad SAGIV_CD24_TARGETS_DN View Gene Set 0.0002435 45 0.005495 106 Genes down-regulated in HT29 cells (colon cancer) after knockdown of CD24 [Gene ID=100133941] by both RNAi and monoclonal antibodies. www.broad.mit.e...
Broad ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP View Gene Set 0.0002532 78 0.00566 107 Genes up-regulated in P493-6 cells (B lymphocyte) by MYC [Gene ID=4609] and down-regulated by RNAi knockdown of TFRC [Gene ID=7037]. www.broad.mit.e...
Broad PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN View Gene Set 0.0002648 123 0.005864 108 Down-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. www.broad.mit.e...
Broad WEST_ADRENOCORTICAL_TUMOR_MARKERS_DN View Gene Set 0.0002817 20 0.006182 109 Top down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. www.broad.mit.e...
Broad RIGGI_EWING_SARCOMA_PROGENITOR_UP View Gene Set 0.0002877 399 0.006227 110 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130 2321] fusion protein. www.broad.mit.e...
Broad HUANG_FOXA2_TARGETS_DN View Gene Set 0.0002889 36 0.006227 110 Genes down-regulated in H358 cells (lung cancer) by inducible expression of FOXA2 [GeneID=3170] in a Tet-off system. www.broad.mit.e...
Broad GILDEA_METASTASIS View Gene Set 0.0002916 29 0.006227 112 Top genes down-regulated in metastatic (T24T) vs non-metastatic (T24) bladder cancer cell lines. www.broad.mit.e...
Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP View Gene Set 0.0003007 74 0.006365 113 Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. www.broad.mit.e...
Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN View Gene Set 0.0003098 167 0.0065 114 Genes down-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [Gene ID=9260] a latent gene of Epstein-Barr virus (EBV). www.broad.mit.e...
Broad MANALO_HYPOXIA_UP View Gene Set 0.000317 197 0.006593 115 Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. www.broad.mit.e...
Broad ROZANOV_MMP14_TARGETS_UP View Gene Set 0.0003447 260 0.007107 116 Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [Gene ID=4323] compared to those with knockdown of the gene by RNAi. www.broad.mit.e...
Broad RIGGINS_TAMOXIFEN_RESISTANCE_DN View Gene Set 0.0003538 211 0.007233 117 Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug. www.broad.mit.e...
Broad LINDSTEDT_DENDRITIC_CELL_MATURATION_A View Gene Set 0.0003947 54 0.008 118 Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 8 hr after the stimulation (cluster A). www.broad.mit.e...
Broad MAHADEVAN_RESPONSE_TO_MP470_DN View Gene Set 0.0004062 16 0.008133 119 Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line sensitive to imatinib [PubChem=5291] after treatment with MP470 a protein kinase inhibitor. www.broad.mit.e...
Broad BOYLAN_MULTIPLE_MYELOMA_C_D_DN View Gene Set 0.000408 232 0.008133 119 Genes down-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [Gene ID=598 4609] in plasma cells. www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN View Gene Set 0.0004169 192 0.008242 121 Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 8 days after transduction. www.broad.mit.e...
Broad SMID_BREAST_CANCER_BASAL_DN View Gene Set 0.0004217 664 0.008267 122 Genes down-regulated in basal subtype of breast cancer samles. www.broad.mit.e...
Broad LIANG_SILENCED_BY_METHYLATION_UP View Gene Set 0.0004724 20 0.009186 123 Genes up-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN View Gene Set 0.0004932 485 0.009437 124 Genes down-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. www.broad.mit.e...
Broad UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN View Gene Set 0.0004913 37 0.009437 124 Genes up-regulated in HUVEC cells (primary endothelium) after stimulation with leukotriene LTD4 [PubChem=3908] or thrombin (F2) [Gene ID=2147] for 1 h. www.broad.mit.e...
Broad GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP View Gene Set 0.0005072 55 0.009628 126 Genes up-regulated in quescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of CML (chronic myeloblastic leukemia) patients compared to the dividing cells from normal donors. www.broad.mit.e...
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 View Gene Set 0.0005313 681 0.01001 127 The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099 2064]. www.broad.mit.e...
Broad OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP View Gene Set 0.0006067 224 0.01118 128 Genes up-regulated in hematopoietic stem cells (HSC CD34+ [Gene ID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension. www.broad.mit.e...
Broad OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN View Gene Set 0.0006067 224 0.01118 128 Genes down-regulated in hematopoietic stem cells (HSC CD34+ [Gene ID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension. www.broad.mit.e...
Broad AMIT_EGF_RESPONSE_60_MCF10A View Gene Set 0.0006114 38 0.01118 128 Genes whose expression peaked at 60 min after stimulation of MCF10A cells with EGF [Gene ID=1950]. www.broad.mit.e...
Broad DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP View Gene Set 0.0006121 242 0.01118 128 Genes up-regulated in HEK293 cells (embryonic kidney) at 6 h 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis). www.broad.mit.e...
Broad RAY_TARGETS_OF_P210_BCR_ABL_FUSION_DN View Gene Set 0.0006496 13 0.01177 132 Genes down-regulated in HL-60 cells (acute myeloid leukemia AML) by expression of p210 BCR-ABL [Gene ID=613 25] fusion protein. www.broad.mit.e...
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 View Gene Set 0.000665 377 0.01196 133 The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099 2064]. www.broad.mit.e...
Broad SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP View Gene Set 0.0006914 157 0.01216 134 Genes up-regulated in circulating endothelial cells (CEC) from cancer patients compared to those from healthy donors. www.broad.mit.e...
Broad ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN View Gene Set 0.0006903 100 0.01216 134 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [Gene ID=3091 2034] by RNAi. www.broad.mit.e...
Broad BECKER_TAMOXIFEN_RESISTANCE_DN View Gene Set 0.0006885 48 0.01216 134 Genes down-regulated in a breast cancer cell line resistant to tamoxifen [PubChem ID=5376] compared to the parental line sensitive to the drug. www.broad.mit.e...
Broad SENESE_HDAC1_AND_HDAC2_TARGETS_DN View Gene Set 0.0007335 218 0.01271 137 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [Gene ID=3065 3066] by RNAi. www.broad.mit.e...
Broad WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP View Gene Set 0.0007318 110 0.01271 137 Genes specific to esophageal adenocarcinoma (EAC) relative to normal tissue. www.broad.mit.e...
Broad RIGGI_EWING_SARCOMA_PROGENITOR_DN View Gene Set 0.0007872 178 0.01355 139 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130 2321] fusion protein. www.broad.mit.e...
Broad LEE_DIFFERENTIATING_T_LYMPHOCYTE View Gene Set 0.0008363 129 0.01429 140 Genes enriched at every T lymphocyte differentiation stage compared to the early passage fetal thymic stromal cultures (TSC). www.broad.mit.e...
Broad LAIHO_COLORECTAL_CANCER_SERRATED_UP View Gene Set 0.0008445 108 0.01433 141 Genes up-regulated in serrated vs conventional colorectal carcinoma (CRC) samples. www.broad.mit.e...
Broad TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN View Gene Set 0.0008728 138 0.0144 142 Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928 3205] off a retroviral vector at 10 days after transduction. www.broad.mit.e...
Broad CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP View Gene Set 0.0008694 228 0.0144 142 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402] a protease inhibitor causing apoptosis. www.broad.mit.e...
Broad FOSTER_INFLAMMATORY_RESPONSE_LPS_DN View Gene Set 0.0008579 369 0.0144 142 Genes down-regulated by bacterial lipopolysaccharide (LPS) in non-tolerizeable (NT class) macrophages compared to the ???tolerizeable??? (T class) ones. www.broad.mit.e...
Broad RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP View Gene Set 0.0008614 394 0.0144 142 Genes up-regulated in peripheral blood mononucleocytes by HGF [Gene ID=3082] compared to those regulated by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. www.broad.mit.e...
Broad BILD_CTNNB1_ONCOGENIC_SIGNATURE View Gene Set 0.0009245 72 0.01515 146 Genes selected in supervised analyses to discriminate cells expressing activated beta-catenin (CTNNB1) [Gene ID=1499] oncogene from control cells expressing GFP. www.broad.mit.e...
Broad CHANG_IMMORTALIZED_BY_HPV31_DN View Gene Set 0.00096 47 0.01562 147 Genes down-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain. www.broad.mit.e...
Broad YANG_BREAST_CANCER_ESR1_DN View Gene Set 0.000979 19 0.01582 148 Genes down-regulated in early primary breast tumors expressing ESR1 [Gene ID=2099] vs the ESR1 negative ones. www.broad.mit.e...
Broad TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN View Gene Set 0.001027 186 0.01638 149 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. www.broad.mit.e...
Broad SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 View Gene Set 0.001023 407 0.01638 149 Genes up-regulated in the pancreatic cancer cell lines (AsPC1 Hs766T MiaPaCa2 Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. www.broad.mit.e...
Broad RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN View Gene Set 0.001039 301 0.01645 151 Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. www.broad.mit.e...
Broad CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN View Gene Set 0.001132 36 0.01782 152 Selected genes down-regulated during invasion of lymphatic vessels during metastasis. www.broad.mit.e...
Broad GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP View Gene Set 0.001154 38 0.01802 153 Genes up-regulated in common hematopoietic progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [Gene ID=6223]. www.broad.mit.e...
Broad SABATES_COLORECTAL_ADENOMA_DN View Gene Set 0.00116 276 0.01802 153 Genes down-regulated in colorectal adenoma compared to normal mucosa samples. www.broad.mit.e...
Broad ONDER_CDH1_TARGETS_2_DN View Gene Set 0.001196 453 0.01846 155 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. www.broad.mit.e...
Broad HAMAI_APOPTOSIS_VIA_TRAIL_UP View Gene Set 0.001211 328 0.01851 156 Genes up-regulated in T1 cells (primary melanoma sensitive to TRAIL [Gene ID=8743]) compared to G1 cells (metastatic melanoma resistant to TRAIL). www.broad.mit.e...
Broad DAUER_STAT3_TARGETS_UP View Gene Set 0.001215 39 0.01851 156 Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [Gene ID=6774] off an adenovirus vector. www.broad.mit.e...
Broad AMIT_EGF_RESPONSE_60_HELA View Gene Set 0.001269 43 0.01921 158 Genes whose expression peaked at 60 min after stimulation of HeLa cells with EGF [Gene ID=1950]. www.broad.mit.e...
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN View Gene Set 0.001302 444 0.01959 159 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. www.broad.mit.e...
Broad GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP View Gene Set 0.001412 23 0.02104 160 Genes up-regulated in quiescent (G0) vs dividing (M) CD34+ [Gene ID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients. www.broad.mit.e...
Broad PEREZ_TP63_TARGETS View Gene Set 0.001416 328 0.02104 160 Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vector. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP View Gene Set 0.001462 716 0.02159 162 Genes up-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h. www.broad.mit.e...
Broad ALONSO_METASTASIS_NEURAL_UP View Gene Set 0.001538 16 0.02257 163 Neural-related genes up-regulated in melanoma tumors that developed metastases compared to primary melanoma that did not. www.broad.mit.e...
Broad TSUNODA_CISPLATIN_RESISTANCE_DN View Gene Set 0.001552 28 0.02264 164 Genes down-regulated in bladder cancer cells resistant to cisplatin [PubChem=2767] compared to the parental cells sensitive to the drug. www.broad.mit.e...
Broad ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN View Gene Set 0.001567 262 0.02272 165 Genes down-regulated in liver tumor compared to the normal adjacent tissue. www.broad.mit.e...
Broad CERVERA_SDHB_TARGETS_1_UP View Gene Set 0.001597 110 0.02296 166 Genes turned on in Hep3B cells (hepatocellular carcinoma HCC) upon knockdown of SDHB [Gene ID=6390] by RNAi. www.broad.mit.e...
Broad PALOMERO_GSI_SENSITIVITY_DN View Gene Set 0.001603 5 0.02296 166 Down-regulated genes associated with sensitivity and resistance to gamma-secretase (GSI) in T-cell acute lymphoblastic leukemia (T-ALL) cell lines. www.broad.mit.e...
Broad KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP View Gene Set 0.001673 126 0.02381 168 Genes up-regulated in glioma cell lines treated with both decitabine [PubChem=451668] and TSA [PubChem=5562]. www.broad.mit.e...
Broad BILBAN_B_CLL_LPL_DN View Gene Set 0.001725 39 0.02439 169 Genes down-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [Gene ID=4023] compared with those expressing low levels of the gene. www.broad.mit.e...
Broad HUPER_BREAST_BASAL_VS_LUMINAL_UP View Gene Set 0.001733 54 0.02439 169 Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. www.broad.mit.e...
Broad CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP View Gene Set 0.001798 165 0.02498 171 Genes up-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [Gene ID=5371 5914] compared to normal promyeloblasts. www.broad.mit.e...
Broad SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN View Gene Set 0.001806 26 0.02498 171 Genes down-regulated in pleura relapse of breast cancer. www.broad.mit.e...
Broad BROWNE_HCMV_INFECTION_20HR_DN View Gene Set 0.001789 107 0.02498 171 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 20 h time point that were not down-regulated at the previous time point 18 h. www.broad.mit.e...
Broad NIELSEN_SYNOVIAL_SARCOMA_DN View Gene Set 0.001839 8 0.02529 174 Top 20 negative significant genes associated with synovial sarcoma tumors. www.broad.mit.e...
Broad NOJIMA_SFRP2_TARGETS_UP View Gene Set 0.001883 30 0.02574 175 Cellular proliferation growth apoptosis and Wnt signaling genes up-regulated in SNU638 cells (gastric cancer) by overexpression of SFRP2 [Gene ID=6423] off a plasmid vector. www.broad.mit.e...
Broad CHEN_HOXA5_TARGETS_6HR_UP View Gene Set 0.001925 10 0.02616 176 Differentially expressed genes 6 hr after tinduction of HoxA5 [Gene ID=3205] expression in a breast cancer cell line. www.broad.mit.e...
Broad ROY_WOUND_BLOOD_VESSEL_DN View Gene Set 0.001963 21 0.02653 177 Genes down-regulated in blood vessel cells from wound site. www.broad.mit.e...
Broad ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP View Gene Set 0.00203 458 0.02728 178 Genes up-regulated in macrophage by live P.gingivalis. www.broad.mit.e...
Broad JAATINEN_HEMATOPOIETIC_STEM_CELL_DN View Gene Set 0.00205 215 0.0274 179 Genes up-regulated in CD133+ [Gene ID=8842] cells (hematopoietic stem cells HSC) compared to the CD133- cells. www.broad.mit.e...
Broad ISHIKAWA_STING_SIGNALING View Gene Set 0.002106 9 0.02799 180 Prmary innate immune response genes induced in 293T cells (embryonic kidney) by overexpression of STING (TMEM173) [Gene ID=340061]. www.broad.mit.e...
Broad BENPORATH_ES_WITH_H3K27ME3 View Gene Set 0.002212 1094 0.02924 181 Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells as identified by ChIP on chip. www.broad.mit.e...
Broad LUI_THYROID_CANCER_CLUSTER_4 View Gene Set 0.002259 14 0.02969 182 Cluster 4: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples. www.broad.mit.e...
Broad DORSAM_HOXA9_TARGETS_UP View Gene Set 0.002376 31 0.03106 183 HOXA9 [Gene ID=3205] targets up-regulated in hematopoietic stem cells. www.broad.mit.e...
Broad GERY_CEBP_TARGETS View Gene Set 0.002452 115 0.03188 184 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA CEBPB CEBPG and CEBPD [Gene ID=1050 1051 1054 1052]. www.broad.mit.e...
Broad GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP View Gene Set 0.002488 24 0.03217 185 Genes up-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [Gene ID=6223]. www.broad.mit.e...
Broad WANG_HCP_PROSTATE_CANCER View Gene Set 0.002507 82 0.03224 186 Genes with the high-CpG-density promoters (HCP) that were up-regulated in 1542-CP3TX cells (prostate cancer) compared to 1542-NPTX (normal prostate). www.broad.mit.e...
Broad SOUCEK_MYC_TARGETS View Gene Set 0.002576 10 0.03295 187 Chemokine genes up-regulated within 2 hr of c-Myc [Gene ID=4609] activation in a mouse model of Myc-induced pancreatic beta-cell tumorigenesis. www.broad.mit.e...
Broad KYNG_DNA_DAMAGE_UP View Gene Set 0.002629 100 0.03345 188 Genes changed after DNA damage in cell lines from young donors and that had a GO annotation. www.broad.mit.e...
Broad COWLING_MYCN_TARGETS View Gene Set 0.002646 41 0.03346 189 Genes down-regulated by MYCN [Gene ID=4613] but not by its transactivation-defficient trunkated form N-Myc-delta-73. www.broad.mit.e...
Broad BROCKE_APOPTOSIS_REVERSED_BY_IL6 View Gene Set 0.002658 140 0.03346 189 Genes changed in INA-6 cells (multiple myeloma MM) by re-addition of IL6 [Gene ID=3569] after its initial withdrawal for 12h. www.broad.mit.e...
Broad SENESE_HDAC2_TARGETS_DN View Gene Set 0.002703 124 0.03385 191 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [Gene ID=3066] by RNAi. www.broad.mit.e...
Broad MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN View Gene Set 0.002856 64 0.03558 192 Down-regulated 'cooperation response genes': responded synergystically to the combination of mutant TP53 [Gene ID=7157] and HRAS [Gene ID=3265] in YAMC cells (colon). www.broad.mit.e...
Broad KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN View Gene Set 0.002875 306 0.03564 193 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) upon knockdown of the EWSR1-FLII fusion [Gene ID=2130 2314]. www.broad.mit.e...
Broad MUELLER_METHYLATED_IN_GLIOBLASTOMA View Gene Set 0.003002 42 0.03702 194 Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment. www.broad.mit.e...
Broad RUTELLA_RESPONSE_TO_HGF_UP View Gene Set 0.003027 409 0.03713 195 Genes up-regulated in peripheral blood monocytes by HGF [Gene ID=3082]. www.broad.mit.e...
Broad SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 View Gene Set 0.003133 48 0.03823 196 50 most interesting genes up-regulated in the pancreatic cancer cell lines (AsPC1 Hs766T MiaPaCa2 Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. www.broad.mit.e...
Broad LINDSTEDT_DENDRITIC_CELL_MATURATION_B View Gene Set 0.003221 47 0.03911 197 Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated both at 8 hr and 48 hr after the stimulation (cluster B). www.broad.mit.e...
Broad LIU_SOX4_TARGETS_UP View Gene Set 0.003346 131 0.03986 198 Genes up-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [Gene ID=6659] and down-regulated by its RNAi knockdown. www.broad.mit.e...
Broad THUM_SYSTOLIC_HEART_FAILURE_DN View Gene Set 0.003338 221 0.03986 198 Genes down-regulated in samples with systolic heart failure compared to normal hearts. www.broad.mit.e...
Broad KHETCHOUMIAN_TRIM24_TARGETS_UP View Gene Set 0.003335 45 0.03986 198 Retinoic acid-responsive genes up-regulated in hepatocellular carcinoma (HCC) samples of TRIM24 [Gene ID=8805] knockout mice. www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION View Gene Set 8.312e-05 267 0.01546 1 Cytokine-cytokine receptor interaction www.broad.mit.e...

Gene Set Collection: Broad.c4.CGN

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad GNF2_DDX5 View Gene Set 9.573e-07 54 0.0004088 1 Neighborhood of DDX5 www.broad.mit.e...
Broad GNF2_PTPRC View Gene Set 9.797e-06 60 0.002092 2 Neighborhood of PTPRC www.broad.mit.e...
Broad MORF_FSHR View Gene Set 0.0003146 268 0.02686 3 Neighborhood of FSHR www.broad.mit.e...
Broad MORF_IFNA1 View Gene Set 0.0001917 198 0.02686 3 Neighborhood of IFNA1 www.broad.mit.e...
Broad MORF_MAGEA9 View Gene Set 0.0002781 405 0.02686 3 Neighborhood of MAGEA9 www.broad.mit.e...
Broad MORF_CD8A View Gene Set 0.0005045 121 0.0359 6 Neighborhood of CD8A www.broad.mit.e...
Broad GNF2_CD53 View Gene Set 0.0006632 54 0.04046 7 Neighborhood of CD53 www.broad.mit.e...
Broad MORF_KDR View Gene Set 0.0008367 90 0.04466 8 Neighborhood of KDR www.broad.mit.e...

Gene Set Collection: Broad.c4.CM

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad module_75 View Gene Set 1.493e-11 391 6.776e-09 1 Genes in module_75 www.broad.mit.e...
Broad module_46 View Gene Set 5.65e-11 386 1.282e-08 2 Genes in module_46 www.broad.mit.e...
Broad module_171 View Gene Set 1.042e-10 131 1.576e-08 3 Genes in module_171 www.broad.mit.e...
Broad module_1 View Gene Set 2.168e-09 355 2.461e-07 4 Genes in module_1 www.broad.mit.e...
Broad module_208 View Gene Set 2.73e-09 118 2.479e-07 5 Genes in module_208 www.broad.mit.e...
Broad module_84 View Gene Set 3.325e-09 526 2.516e-07 6 Genes in module_84 www.broad.mit.e...
Broad module_345 View Gene Set 6.17e-08 118 4.002e-06 7 Genes in module_345 www.broad.mit.e...
Broad module_45 View Gene Set 1.557e-07 563 8.836e-06 8 Genes in module_45 www.broad.mit.e...
Broad module_292 View Gene Set 1.958e-07 129 9.876e-06 9 Genes in module_292 www.broad.mit.e...
Broad module_436 View Gene Set 2.252e-07 129 1.022e-05 10 Genes in module_436 www.broad.mit.e...
Broad module_117 View Gene Set 2.733e-07 699 1.128e-05 11 Genes in module_117 www.broad.mit.e...
Broad module_119 View Gene Set 4.207e-07 135 1.592e-05 12 Genes in module_119 www.broad.mit.e...
Broad module_2 View Gene Set 6.919e-07 373 2.416e-05 13 Genes in module_2 www.broad.mit.e...
Broad module_5 View Gene Set 1.345e-06 420 4.361e-05 14 Genes in module_5 www.broad.mit.e...
Broad module_64 View Gene Set 2.76e-06 506 8.354e-05 15 Genes in module_64 www.broad.mit.e...
Broad module_66 View Gene Set 7.489e-06 530 0.0002088 16 Genes in module_66 www.broad.mit.e...
Broad module_137 View Gene Set 7.817e-06 525 0.0002088 16 Genes in module_137 www.broad.mit.e...
Broad module_100 View Gene Set 1.387e-05 523 0.0003498 18 Genes in module_100 www.broad.mit.e...
Broad module_44 View Gene Set 2.978e-05 319 0.0007117 19 Genes in module_44 www.broad.mit.e...
Broad module_12 View Gene Set 5.898e-05 346 0.001339 20 Genes in module_12 www.broad.mit.e...
Broad module_55 View Gene Set 8.481e-05 807 0.001833 21 Genes in module_55 www.broad.mit.e...
Broad module_76 View Gene Set 0.0001087 79 0.002244 22 Genes in module_76 www.broad.mit.e...
Broad module_263 View Gene Set 0.0001538 43 0.003036 23 Genes in module_263 www.broad.mit.e...
Broad module_41 View Gene Set 0.000172 542 0.003123 24 Genes in module_41 www.broad.mit.e...
Broad module_324 View Gene Set 0.0001691 131 0.003123 24 Genes in module_324 www.broad.mit.e...
Broad module_24 View Gene Set 0.0002217 443 0.003788 26 Genes in module_24 www.broad.mit.e...
Broad module_88 View Gene Set 0.0002253 812 0.003788 26 Genes in module_88 www.broad.mit.e...
Broad module_112 View Gene Set 0.0002349 255 0.003808 28 Genes in module_112 www.broad.mit.e...
Broad module_6 View Gene Set 0.000336 403 0.005259 29 Genes in module_6 www.broad.mit.e...
Broad module_27 View Gene Set 0.000371 345 0.005615 30 Genes in module_27 www.broad.mit.e...
Broad module_19 View Gene Set 0.0004441 306 0.006301 31 Genes in module_19 www.broad.mit.e...
Broad module_108 View Gene Set 0.0004431 52 0.006301 31 Genes in module_108 www.broad.mit.e...
Broad module_176 View Gene Set 0.0008264 225 0.01137 33 Genes in module_176 www.broad.mit.e...
Broad module_144 View Gene Set 0.001342 8 0.0175 34 Genes in module_144 www.broad.mit.e...
Broad module_418 View Gene Set 0.001349 56 0.0175 34 Genes in module_418 www.broad.mit.e...
Broad module_11 View Gene Set 0.001389 520 0.01751 36 Genes in module_11 www.broad.mit.e...
Broad module_113 View Gene Set 0.001616 105 0.01983 37 Genes in module_113 www.broad.mit.e...
Broad module_23 View Gene Set 0.00196 552 0.02325 38 Genes in module_23 www.broad.mit.e...
Broad module_220 View Gene Set 0.002049 328 0.02325 38 Genes in module_220 www.broad.mit.e...
Broad module_456 View Gene Set 0.002044 108 0.02325 38 Genes in module_456 www.broad.mit.e...
Broad module_238 View Gene Set 0.002394 150 0.02651 41 Genes in module_238 www.broad.mit.e...
Broad module_289 View Gene Set 0.002526 118 0.02731 42 Genes in module_289 www.broad.mit.e...
Broad module_143 View Gene Set 0.003203 14 0.03382 43 Genes in module_143 www.broad.mit.e...
Broad module_357 View Gene Set 0.003677 78 0.03794 44 Genes in module_357 www.broad.mit.e...
Broad module_26 View Gene Set 0.004668 178 0.04709 45 Genes in module_26 www.broad.mit.e...

Gene Set Collection: Broad.c5.BP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad IMMUNE_RESPONSE View Gene Set 3.596e-08 232 2.966e-05 1 Genes annotated by the GO term GO:0006955. Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. www.broad.mit.e...
Broad DEFENSE_RESPONSE View Gene Set 6.871e-07 264 0.0002247 2 Genes annotated by the GO term GO:0006952. Reactions triggered in response to the presence of a foreign body or the occurrence of an injury which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. www.broad.mit.e...
Broad IMMUNE_SYSTEM_PROCESS View Gene Set 8.171e-07 326 0.0002247 2 Genes annotated by the GO term GO:0002376. Any process involved in the development or functioning of the immune system an organismal system for calibrated responses to potential internal or invasive threats. www.broad.mit.e...
Broad INFLAMMATORY_RESPONSE View Gene Set 0.000135 124 0.02784 4 Genes annotated by the GO term GO:0006954. The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. www.broad.mit.e...
Broad RESPONSE_TO_WOUNDING View Gene Set 0.0002245 184 0.03703 5 Genes annotated by the GO term GO:0009611. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of a stimulus indicating damage to the organism. www.broad.mit.e...

Gene Set Collection: Broad.c5.CC

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad EXTRACELLULAR_REGION_PART View Gene Set 7.919e-05 331 0.01845 1 Genes annotated by the GO term GO:0044421. Any constituent part of the extracellular region the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite. www.broad.mit.e...
Broad EXTRACELLULAR_SPACE View Gene Set 0.0001648 239 0.0192 2 Genes annotated by the GO term GO:0005615. That part of a multicellular organism outside the cells proper usually taken to be outside the plasma membranes and occupied by fluid. www.broad.mit.e...

Gene Set Collection: PMID

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
PMID 12539042 View Gene Set 6.65e-06 45 0.008128 1 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. www.ncbi.nlm.ni...
PMID 17703412 View Gene Set 1.291e-05 207 0.008128 1 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. www.ncbi.nlm.ni...
PMID 19258923 View Gene Set 8.829e-06 205 0.008128 1 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. www.ncbi.nlm.ni...
PMID 20503287 View Gene Set 1.297e-05 205 0.008128 1 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. www.ncbi.nlm.ni...
PMID 12447867 View Gene Set 1.981e-05 11 0.008276 5 Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. www.ncbi.nlm.ni...
PMID 9455484 View Gene Set 1.728e-05 56 0.008276 5 Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. www.ncbi.nlm.ni...
PMID 19167759 View Gene Set 0.0001216 10 0.0381 7 HLA-association of serum levels of natural antibodies. www.ncbi.nlm.ni...
PMID 20237496 View Gene Set 0.0001115 828 0.0381 7 New genetic associations detected in a host response study to hepatitis B vaccine. www.ncbi.nlm.ni...

Gene Set Collection: pathwayCommons.reactome

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null Interferon Signaling View Gene Set 1.737e-16 86 1.94e-13 1 REACTOME - Interferon Signaling gene set www.pathwaycomm...
Null Interferon alpha/beta signaling View Gene Set 1.002e-13 65 5.595e-11 2 REACTOME - Interferon alpha/beta signaling gene set www.pathwaycomm...
Null Interferon gamma signaling View Gene Set 4.938e-10 48 1.838e-07 3 REACTOME - Interferon gamma signaling gene set www.pathwaycomm...

Gene Set Collection: miranda.targets

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null hsa-miR-1278 View Gene Set 4.272e-05 1219 0.01478 1 microRNA targets for hsa-miR-1278 from miranda.targets www.mirbase.org...
Null hsa-miR-573 View Gene Set 4.367e-05 2023 0.01478 1 microRNA targets for hsa-miR-573 from miranda.targets www.mirbase.org...
Null hsa-miR-33a View Gene Set 0.0001791 1258 0.03139 3 microRNA targets for hsa-miR-33a from miranda.targets www.mirbase.org...
Null hsa-miR-448 View Gene Set 0.0001855 1660 0.03139 3 microRNA targets for hsa-miR-448 from miranda.targets www.mirbase.org...
Null hsa-miR-340 View Gene Set 0.0002532 2504 0.03428 5 microRNA targets for hsa-miR-340 from miranda.targets www.mirbase.org...
Null hsa-miR-33b View Gene Set 0.0003967 1071 0.04476 6 microRNA targets for hsa-miR-33b from miranda.targets www.mirbase.org...

Gene Set Collection: mirbase.targets

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null hsa-miR-93 View Gene Set 2.801e-05 897 0.01992 1 microRNA targets for hsa-miR-93 from mirbase.targets www.mirbase.org...
Null hsa-miR-17 View Gene Set 9.981e-05 935 0.02366 2 microRNA targets for hsa-miR-17 from mirbase.targets www.mirbase.org...
Null hsa-miR-20b View Gene Set 7.718e-05 901 0.02366 2 microRNA targets for hsa-miR-20b from mirbase.targets www.mirbase.org...

Gene Set Collection: miRNAtargetIntersection

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null miranda.mirbase.mirtarget2.targetsIntersection.hsa-miR-32 View Gene Set 4.113e-05 96 0.04224 1 microRNA targets for miranda.mirbase.mirtarget2.targetsIntersection.hsa-miR-32 from miRNAtargetIntersection www.mirbase.org...
Null miranda.mirtarget2.targetscan.targetsIntersection.hsa-miR-33a View Gene Set 2.213e-05 46 0.04224 1 microRNA targets for miranda.mirtarget2.targetscan.targetsIntersection.hsa-miR-33a from miRNAtargetIntersection www.mirbase.org...

Gene Set Collection: miRNAtargetUnion

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-448 View Gene Set 4.649e-06 2225 0.01076 1 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-448 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-573 View Gene Set 1.194e-05 2606 0.01381 2 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-573 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-643 View Gene Set 3.402e-05 1567 0.01968 3 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-643 from miRNAtargetUnion www.mirbase.org...
Null mirbase.mirtarget2.tarbase.targetsUnion.hsa-miR-372 View Gene Set 2.928e-05 1009 0.01968 3 microRNA targets for mirbase.mirtarget2.tarbase.targetsUnion.hsa-miR-372 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-18b View Gene Set 0.0003057 2045 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-18b from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-301b View Gene Set 0.000339 2655 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-301b from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-374b View Gene Set 0.0002707 2404 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-374b from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-514 View Gene Set 0.0002572 1503 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-514 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-518a-5p View Gene Set 0.0003412 2389 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-518a-5p from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-93 View Gene Set 0.0001633 3033 0.04644 5 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-93 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.targetscan.targetsUnion.hsa-miR-33b View Gene Set 0.0002811 1741 0.04644 5 microRNA targets for miranda.mirbase.targetscan.targetsUnion.hsa-miR-33b from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.targetscan.targetsUnion.hsa-miR-448 View Gene Set 0.000308 2294 0.04644 5 microRNA targets for miranda.mirbase.targetscan.targetsUnion.hsa-miR-448 from miRNAtargetUnion www.mirbase.org...
Null miranda.mirtarget2.tarbase.targetsUnion.hsa-miR-130a View Gene Set 0.0001867 1799 0.04644 5 microRNA targets for miranda.mirtarget2.tarbase.targetsUnion.hsa-miR-130a from miRNAtargetUnion www.mirbase.org...
Null miranda.mirtarget2.targetscan.targetsUnion.hsa-miR-448 View Gene Set 0.0002674 2038 0.04644 5 microRNA targets for miranda.mirtarget2.targetscan.targetsUnion.hsa-miR-448 from miRNAtargetUnion www.mirbase.org...
Null mirbase.mirtarget2.pictar.targetsUnion.hsa-miR-18b View Gene Set 0.000174 922 0.04644 5 microRNA targets for mirbase.mirtarget2.pictar.targetsUnion.hsa-miR-18b from miRNAtargetUnion www.mirbase.org...
Null mirbase.mirtarget2.pictar.targetsUnion.hsa-miR-20b View Gene Set 0.0001561 1834 0.04644 5 microRNA targets for mirbase.mirtarget2.pictar.targetsUnion.hsa-miR-20b from miRNAtargetUnion www.mirbase.org...
Null mirbase.mirtarget2.tarbase.targetsUnion.hsa-miR-20b View Gene Set 0.0001709 1580 0.04644 5 microRNA targets for mirbase.mirtarget2.tarbase.targetsUnion.hsa-miR-20b from miRNAtargetUnion www.mirbase.org...
Null mirbase.mirtarget2.targetscan.targetsUnion.hsa-miR-18b View Gene Set 0.0003646 948 0.04687 18 microRNA targets for mirbase.mirtarget2.targetscan.targetsUnion.hsa-miR-18b from miRNAtargetUnion www.mirbase.org...
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-33b View Gene Set 0.000399 1676 0.0486 19 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-33b from miRNAtargetUnion www.mirbase.org...

Gene Set Collection: hprdBatch.UP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null IL-6 Signaling Pathway View Gene Set 0.0008435 80 0.01687 1 From NetPath for IL-6 Signaling Pathway www.netpath.org...
Null TNF-alpha Signaling Pathway View Gene Set 0.002347 728 0.02347 2 From NetPath for TNF-alpha Signaling Pathway www.netpath.org...

Gene Set Collection: hprdBatch.DOWN

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null T Cell Receptor Signaling Pathway View Gene Set 5.532e-06 68 0.0001051 1 From NetPath for T Cell Receptor Signaling Pathway www.netpath.org...
Null IL-4 Signaling Pathway View Gene Set 4.004e-05 90 0.0003804 2 From NetPath for IL-4 Signaling Pathway www.netpath.org...

Gene Set Collection: hprdBatch.DIFFERENT

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null IL-4 Signaling Pathway View Gene Set 0.0043 301 0.04485 1 From NetPath for IL-4 Signaling Pathway www.netpath.org...
Null TNF-alpha Signaling Pathway View Gene Set 0.004485 863 0.04485 1 From NetPath for TNF-alpha Signaling Pathway www.netpath.org...

Gene Set Collection: hprdManual.UP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null IL1 View Gene Set 0.0001846 85 0.004431 1 From NetPath for IL1 www.netpath.org...
Null TNFalpha View Gene Set 0.0006067 113 0.00728 2 From NetPath for TNFalpha www.netpath.org...

Gene Set Collection: hprdManual.DOWN

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null IL4 View Gene Set 0.0005006 77 0.006137 1 From NetPath for IL4 www.netpath.org...
Null TCR View Gene Set 0.000646 178 0.006137 1 From NetPath for TCR www.netpath.org...
Null IL-7 View Gene Set 0.00315 9 0.01995 3 From NetPath for IL-7 www.netpath.org...
Null Leptin View Gene Set 0.005785 79 0.02725 4 From NetPath for Leptin www.netpath.org...
Null TGF_beta_Receptor View Gene Set 0.007263 399 0.02725 4 From NetPath for TGF_beta_Receptor www.netpath.org...
Null TSH View Gene Set 0.008604 45 0.02725 4 From NetPath for TSH www.netpath.org...

Gene Set Collection: hprdManual.DIFFERENT

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null TNFalpha View Gene Set 0.000423 121 0.01015 1 From NetPath for TNFalpha www.netpath.org...
Null IL1 View Gene Set 0.001472 120 0.01766 2 From NetPath for IL1 www.netpath.org...
Null Leptin View Gene Set 0.003048 110 0.02438 3 From NetPath for Leptin www.netpath.org...
Null IL5 View Gene Set 0.005902 144 0.03541 4 From NetPath for IL5 www.netpath.org...

Gene Set Collection: tfbsK3Z3

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxUP, ranks.only=TRUE, absolute=FALSE, alternative=up

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null V_EVI1_01 View Gene Set 5.487e-05 265 0.01169 1 List of genes containing a conserved (FDR < 0.1%) V$EVI1_01 TFBS located within 3 kb around the TSS for the Evi-1 transcription factor www.gene-regula...