Results

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Go to: Gene Set Collection: KEGG
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Go to: Gene Set Collection: Broad.c2.CP.KEGG
Go to: Gene Set Collection: Broad.c2.CP.REACTOME
Go to: Gene Set Collection: Broad.c3.TFT
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Go to: Gene Set Collection: Broad.c5.BP
Go to: Gene Set Collection: Broad.c5.CC
Go to: Gene Set Collection: Broad.c5.MF
Go to: Gene Set Collection: PMID
Go to: Gene Set Collection: ChromosomalTiles5Mb
Go to: Gene Set Collection: Prosite
Go to: Gene Set Collection: ppi.BIND
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Go to: Gene Set Collection: ppi.anyDB
Go to: Gene Set Collection: pathwayCommons.cell-map
Go to: Gene Set Collection: pathwayCommons.humancyc
Go to: Gene Set Collection: pathwayCommons.nci-nature
Go to: Gene Set Collection: pathwayCommons.reactome
Go to: Gene Set Collection: mirbase.targets
Go to: Gene Set Collection: miRNAtargetUnion

AFA results for: tSAHAda2DU

Click on the heading for any column to sort by that column.

Gene Set Collection: KEGG

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
KEGG 03040 View Gene Set 3.631e-16 128 7.769e-14 1 Spliceosome www.genome.jp/d...
KEGG 03018 View Gene Set 2.32e-08 59 1.655e-06 2 RNA degradation www.genome.jp/d...
KEGG 04110 View Gene Set 1.569e-08 128 1.655e-06 2 Cell cycle www.genome.jp/d...
KEGG 00240 View Gene Set 2.149e-07 99 1.15e-05 4 Pyrimidine metabolism www.genome.jp/d...
KEGG 03050 View Gene Set 2.767e-06 48 0.0001184 5 Proteasome www.genome.jp/d...
KEGG 03030 View Gene Set 2.14e-05 36 0.0007633 6 DNA replication www.genome.jp/d...
KEGG 00970 View Gene Set 2.536e-05 41 0.0007754 7 Aminoacyl-tRNA biosynthesis www.genome.jp/d...
KEGG 03440 View Gene Set 3.122e-05 28 0.000835 8 Homologous recombination www.genome.jp/d...
KEGG 03430 View Gene Set 5.715e-05 23 0.001359 9 Mismatch repair www.genome.jp/d...
KEGG 03410 View Gene Set 0.0001637 34 0.003504 10 Base excision repair www.genome.jp/d...
KEGG 03020 View Gene Set 0.0002165 29 0.004213 11 RNA polymerase www.genome.jp/d...
KEGG 03420 View Gene Set 0.0004468 44 0.007968 12 Nucleotide excision repair www.genome.jp/d...
KEGG 00230 View Gene Set 0.002662 161 0.04382 13 Purine metabolism www.genome.jp/d...

Gene Set Collection: GO

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
GO GO:0044428 View Gene Set 4.195e-54 1938 5.604e-50 1 nuclear part amigo.geneontol...
GO GO:0031974 View Gene Set 9.367e-50 1917 6.257e-46 2 membrane-enclosed lumen amigo.geneontol...
GO GO:0070013 View Gene Set 4.402e-49 1845 1.961e-45 3 intracellular organelle lumen amigo.geneontol...
GO GO:0043233 View Gene Set 4.53e-48 1881 1.513e-44 4 organelle lumen amigo.geneontol...
GO GO:0005634 View Gene Set 5.068e-45 5198 1.354e-41 5 nucleus amigo.geneontol...
GO GO:0031981 View Gene Set 7.646e-44 1518 1.703e-40 6 nuclear lumen amigo.geneontol...
GO GO:0006396 View Gene Set 2.288e-38 578 4.366e-35 7 RNA processing amigo.geneontol...
GO GO:0003676 View Gene Set 4.187e-36 2979 6.992e-33 8 nucleic acid binding amigo.geneontol...
GO GO:0090304 View Gene Set 4.273e-33 3724 6.343e-30 9 nucleic acid metabolic process amigo.geneontol...
GO GO:0030529 View Gene Set 5.295e-32 504 7.074e-29 10 ribonucleoprotein complex amigo.geneontol...
GO GO:0034641 View Gene Set 1.446e-28 4584 1.756e-25 11 cellular nitrogen compound metabolic process amigo.geneontol...
GO GO:0006139 View Gene Set 2.244e-28 4294 2.498e-25 12 nucleobase nucleoside nucleotide and nucleic acid metabolic process amigo.geneontol...
GO GO:0000279 View Gene Set 2.743e-28 406 2.819e-25 13 M phase amigo.geneontol...
GO GO:0043228 View Gene Set 8.482e-27 2690 7.554e-24 14 non-membrane-bounded organelle amigo.geneontol...
GO GO:0043232 View Gene Set 8.482e-27 2690 7.554e-24 14 intracellular non-membrane-bounded organelle amigo.geneontol...
GO GO:0006807 View Gene Set 5.463e-26 4698 4.561e-23 16 nitrogen compound metabolic process amigo.geneontol...
GO GO:0044260 View Gene Set 1.517e-25 5699 1.192e-22 17 cellular macromolecule metabolic process amigo.geneontol...
GO GO:0005654 View Gene Set 6.276e-25 939 4.658e-22 18 nucleoplasm amigo.geneontol...
GO GO:0022402 View Gene Set 1.61e-24 676 1.132e-21 19 cell cycle process amigo.geneontol...
GO GO:0000278 View Gene Set 2.059e-24 489 1.25e-21 20 mitotic cell cycle amigo.geneontol...
GO GO:0022403 View Gene Set 1.906e-24 522 1.25e-21 20 cell cycle phase amigo.geneontol...
GO GO:0003723 View Gene Set 2.003e-24 732 1.25e-21 20 RNA binding amigo.geneontol...
GO GO:0000087 View Gene Set 3.086e-24 286 1.792e-21 23 M phase of mitotic cell cycle amigo.geneontol...
GO GO:0048285 View Gene Set 3.52e-24 286 1.959e-21 24 organelle fission amigo.geneontol...
GO GO:0005694 View Gene Set 6.078e-24 507 3.155e-21 25 chromosome amigo.geneontol...
GO GO:0005730 View Gene Set 6.14e-24 734 3.155e-21 25 nucleolus amigo.geneontol...
GO GO:0000280 View Gene Set 9.7e-24 276 4.628e-21 27 nuclear division amigo.geneontol...
GO GO:0007067 View Gene Set 9.7e-24 276 4.628e-21 27 mitosis amigo.geneontol...
GO GO:0008380 View Gene Set 3.585e-23 300 1.652e-20 29 RNA splicing amigo.geneontol...
GO GO:0010467 View Gene Set 2.876e-22 3806 1.281e-19 30 gene expression amigo.geneontol...
GO GO:0034660 View Gene Set 7.884e-22 236 3.398e-19 31 ncRNA metabolic process amigo.geneontol...
GO GO:0043170 View Gene Set 2.21e-21 6274 9.229e-19 32 macromolecule metabolic process amigo.geneontol...
GO GO:0000775 View Gene Set 2.731e-21 146 1.105e-18 33 chromosome centromeric region amigo.geneontol...
GO GO:0007049 View Gene Set 3.693e-21 1006 1.451e-18 34 cell cycle amigo.geneontol...
GO GO:0000793 View Gene Set 4.592e-21 136 1.753e-18 35 condensed chromosome amigo.geneontol...
GO GO:0016070 View Gene Set 4.872e-21 2596 1.808e-18 36 RNA metabolic process amigo.geneontol...
GO GO:0032991 View Gene Set 2.035e-20 3237 7.348e-18 37 macromolecular complex amigo.geneontol...
GO GO:0034470 View Gene Set 2.614e-20 193 9.191e-18 38 ncRNA processing amigo.geneontol...
GO GO:0022613 View Gene Set 2.854e-20 194 9.777e-18 39 ribonucleoprotein complex biogenesis amigo.geneontol...
GO GO:0044427 View Gene Set 8.373e-20 420 2.797e-17 40 chromosomal part amigo.geneontol...
GO GO:0043227 View Gene Set 2.387e-19 8383 7.777e-17 41 membrane-bounded organelle amigo.geneontol...
GO GO:0043231 View Gene Set 4.384e-19 8376 1.395e-16 42 intracellular membrane-bounded organelle amigo.geneontol...
GO GO:0000776 View Gene Set 6.426e-19 92 1.996e-16 43 kinetochore amigo.geneontol...
GO GO:0016071 View Gene Set 1.514e-18 381 4.598e-16 44 mRNA metabolic process amigo.geneontol...
GO GO:0044446 View Gene Set 1.939e-18 5019 5.757e-16 45 intracellular organelle part amigo.geneontol...
GO GO:0000777 View Gene Set 2.654e-18 74 7.708e-16 46 condensed chromosome kinetochore amigo.geneontol...
GO GO:0043229 View Gene Set 2.914e-18 9346 8.282e-16 47 intracellular organelle amigo.geneontol...
GO GO:0043226 View Gene Set 4.257e-18 9360 1.185e-15 48 organelle amigo.geneontol...
GO GO:0044422 View Gene Set 9.19e-18 5089 2.506e-15 49 organelle part amigo.geneontol...
GO GO:0000779 View Gene Set 1.886e-17 79 5.039e-15 50 condensed chromosome centromeric region amigo.geneontol...
GO GO:0005681 View Gene Set 2.287e-17 135 5.992e-15 51 spliceosomal complex amigo.geneontol...
GO GO:0006397 View Gene Set 2.383e-17 317 6.122e-15 52 mRNA processing amigo.geneontol...
GO GO:0051301 View Gene Set 3.352e-17 358 8.448e-15 53 cell division amigo.geneontol...
GO GO:0005819 View Gene Set 5.048e-17 167 1.249e-14 54 spindle amigo.geneontol...
GO GO:0007059 View Gene Set 1.01e-16 94 2.454e-14 55 chromosome segregation amigo.geneontol...
GO GO:0042254 View Gene Set 7.064e-16 130 1.685e-13 56 ribosome biogenesis amigo.geneontol...
GO GO:0044237 View Gene Set 1.168e-15 7431 2.738e-13 57 cellular metabolic process amigo.geneontol...
GO GO:0051276 View Gene Set 3.187e-15 548 7.341e-13 58 chromosome organization amigo.geneontol...
GO GO:0016072 View Gene Set 3.756e-15 101 8.505e-13 59 rRNA metabolic process amigo.geneontol...
GO GO:0006364 View Gene Set 9.359e-15 97 2.084e-12 60 rRNA processing amigo.geneontol...
GO GO:0044238 View Gene Set 3.29e-14 7629 7.205e-12 61 primary metabolic process amigo.geneontol...
GO GO:0006281 View Gene Set 4.078e-14 309 8.788e-12 62 DNA repair amigo.geneontol...
GO GO:0007051 View Gene Set 7.426e-14 57 1.575e-11 63 spindle organization amigo.geneontol...
GO GO:0006259 View Gene Set 1.258e-13 592 2.625e-11 64 DNA metabolic process amigo.geneontol...
GO GO:0009059 View Gene Set 2.696e-13 3597 5.541e-11 65 macromolecule biosynthetic process amigo.geneontol...
GO GO:0034645 View Gene Set 5.246e-13 3529 1.062e-10 66 cellular macromolecule biosynthetic process amigo.geneontol...
GO GO:0000922 View Gene Set 6.233e-13 63 1.243e-10 67 spindle pole amigo.geneontol...
GO GO:0000166 View Gene Set 1.038e-12 2257 2.04e-10 68 nucleotide binding amigo.geneontol...
GO GO:0000375 View Gene Set 1.296e-12 106 2.509e-10 69 RNA splicing via transesterification reactions amigo.geneontol...
GO GO:0006996 View Gene Set 2.757e-12 1501 5.262e-10 70 organelle organization amigo.geneontol...
GO GO:0044249 View Gene Set 3.66e-12 4326 6.859e-10 71 cellular biosynthetic process amigo.geneontol...
GO GO:0044424 View Gene Set 3.696e-12 10976 6.859e-10 71 intracellular part amigo.geneontol...
GO GO:0000819 View Gene Set 4.588e-12 38 8.396e-10 73 sister chromatid segregation amigo.geneontol...
GO GO:0006974 View Gene Set 5.33e-12 412 9.623e-10 74 response to DNA damage stimulus amigo.geneontol...
GO GO:0000070 View Gene Set 6.457e-12 37 1.15e-09 75 mitotic sister chromatid segregation amigo.geneontol...
GO GO:0044451 View Gene Set 8.676e-12 600 1.525e-09 76 nucleoplasm part amigo.geneontol...
GO GO:0031145 View Gene Set 1.188e-11 64 2.062e-09 77 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process amigo.geneontol...
GO GO:0000377 View Gene Set 1.329e-11 97 2.247e-09 78 RNA splicing via transesterification reactions with bulged adenosine as nucleophile amigo.geneontol...
GO GO:0000398 View Gene Set 1.329e-11 97 2.247e-09 78 nuclear mRNA splicing via spliceosome amigo.geneontol...
GO GO:0007017 View Gene Set 1.498e-11 281 2.502e-09 80 microtubule-based process amigo.geneontol...
GO GO:0051439 View Gene Set 3.744e-11 68 6.175e-09 81 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle amigo.geneontol...
GO GO:0005759 View Gene Set 3.851e-11 223 6.198e-09 82 mitochondrial matrix amigo.geneontol...
GO GO:0031980 View Gene Set 3.851e-11 223 6.198e-09 82 mitochondrial lumen amigo.geneontol...
GO GO:0009058 View Gene Set 4.203e-11 4436 6.685e-09 84 biosynthetic process amigo.geneontol...
GO GO:0003677 View Gene Set 4.814e-11 2028 7.567e-09 85 DNA binding amigo.geneontol...
GO GO:0008152 View Gene Set 4.937e-11 8439 7.669e-09 86 metabolic process amigo.geneontol...
GO GO:0006399 View Gene Set 7.828e-11 118 1.202e-08 87 tRNA metabolic process amigo.geneontol...
GO GO:0006412 View Gene Set 7.994e-11 412 1.207e-08 88 translation amigo.geneontol...
GO GO:0051436 View Gene Set 8.039e-11 62 1.207e-08 88 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle amigo.geneontol...
GO GO:0005815 View Gene Set 9.854e-11 277 1.463e-08 90 microtubule organizing center amigo.geneontol...
GO GO:0050657 View Gene Set 1.35e-10 102 1.919e-08 91 nucleic acid transport amigo.geneontol...
GO GO:0050658 View Gene Set 1.35e-10 102 1.919e-08 91 RNA transport amigo.geneontol...
GO GO:0051236 View Gene Set 1.35e-10 102 1.919e-08 91 establishment of RNA localization amigo.geneontol...
GO GO:0051437 View Gene Set 1.314e-10 64 1.919e-08 91 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle amigo.geneontol...
GO GO:0000226 View Gene Set 1.527e-10 178 2.148e-08 95 microtubule cytoskeleton organization amigo.geneontol...
GO GO:0005739 View Gene Set 1.665e-10 1274 2.317e-08 96 mitochondrion amigo.geneontol...
GO GO:0051351 View Gene Set 2.114e-10 74 2.912e-08 97 positive regulation of ligase activity amigo.geneontol...
GO GO:0051443 View Gene Set 3.06e-10 71 4.171e-08 98 positive regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0015630 View Gene Set 3.152e-10 587 4.253e-08 99 microtubule cytoskeleton amigo.geneontol...
GO GO:0051352 View Gene Set 4.98e-10 66 6.587e-08 100 negative regulation of ligase activity amigo.geneontol...
GO GO:0051444 View Gene Set 4.98e-10 66 6.587e-08 100 negative regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0005622 View Gene Set 5.062e-10 11329 6.631e-08 102 intracellular amigo.geneontol...
GO GO:0006260 View Gene Set 5.401e-10 239 7.005e-08 103 DNA replication amigo.geneontol...
GO GO:0046930 View Gene Set 5.609e-10 85 7.205e-08 104 pore complex amigo.geneontol...
GO GO:0006403 View Gene Set 6.489e-10 104 8.179e-08 105 RNA localization amigo.geneontol...
GO GO:0051340 View Gene Set 6.472e-10 85 8.179e-08 105 regulation of ligase activity amigo.geneontol...
GO GO:0006261 View Gene Set 7.434e-10 74 9.282e-08 107 DNA-dependent DNA replication amigo.geneontol...
GO GO:0000228 View Gene Set 9.349e-10 177 1.156e-07 108 nuclear chromosome amigo.geneontol...
GO GO:0051438 View Gene Set 9.714e-10 82 1.191e-07 109 regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0005643 View Gene Set 1.254e-09 71 1.522e-07 110 nuclear pore amigo.geneontol...
GO GO:0008026 View Gene Set 1.313e-09 105 1.567e-07 111 ATP-dependent helicase activity amigo.geneontol...
GO GO:0070035 View Gene Set 1.313e-09 105 1.567e-07 111 purine NTP-dependent helicase activity amigo.geneontol...
GO GO:0015931 View Gene Set 1.34e-09 118 1.584e-07 113 nucleobase nucleoside nucleotide and nucleic acid transport amigo.geneontol...
GO GO:0005876 View Gene Set 1.721e-09 35 2.017e-07 114 spindle microtubule amigo.geneontol...
GO GO:0005840 View Gene Set 2.083e-09 198 2.419e-07 115 ribosome amigo.geneontol...
GO GO:0051028 View Gene Set 2.102e-09 90 2.421e-07 116 mRNA transport amigo.geneontol...
GO GO:0032559 View Gene Set 2.124e-09 1503 2.425e-07 117 adenyl ribonucleotide binding amigo.geneontol...
GO GO:0030554 View Gene Set 2.227e-09 1584 2.521e-07 118 adenyl nucleotide binding amigo.geneontol...
GO GO:0005524 View Gene Set 2.599e-09 1480 2.918e-07 119 ATP binding amigo.geneontol...
GO GO:0004386 View Gene Set 3.445e-09 144 3.835e-07 120 helicase activity amigo.geneontol...
GO GO:0031397 View Gene Set 5.46e-09 78 6.029e-07 121 negative regulation of protein ubiquitination amigo.geneontol...
GO GO:0008033 View Gene Set 5.665e-09 78 6.204e-07 122 tRNA processing amigo.geneontol...
GO GO:0001882 View Gene Set 1.843e-08 1630 2.001e-06 123 nucleoside binding amigo.geneontol...
GO GO:0001883 View Gene Set 2.638e-08 1620 2.842e-06 124 purine nucleoside binding amigo.geneontol...
GO GO:0022618 View Gene Set 2.757e-08 76 2.947e-06 125 ribonucleoprotein complex assembly amigo.geneontol...
GO GO:0031398 View Gene Set 3.732e-08 95 3.957e-06 126 positive regulation of protein ubiquitination amigo.geneontol...
GO GO:0017076 View Gene Set 4.06e-08 1934 4.271e-06 127 purine nucleotide binding amigo.geneontol...
GO GO:0030261 View Gene Set 4.607e-08 27 4.809e-06 128 chromosome condensation amigo.geneontol...
GO GO:0031023 View Gene Set 5.107e-08 41 5.29e-06 129 microtubule organizing center organization amigo.geneontol...
GO GO:0032553 View Gene Set 5.495e-08 1851 5.604e-06 130 ribonucleotide binding amigo.geneontol...
GO GO:0032555 View Gene Set 5.495e-08 1851 5.604e-06 130 purine ribonucleotide binding amigo.geneontol...
GO GO:0000313 View Gene Set 7.186e-08 49 7.218e-06 132 organellar ribosome amigo.geneontol...
GO GO:0005761 View Gene Set 7.186e-08 49 7.218e-06 132 mitochondrial ribosome amigo.geneontol...
GO GO:0000075 View Gene Set 9.814e-08 109 9.785e-06 134 cell cycle checkpoint amigo.geneontol...
GO GO:0044452 View Gene Set 1.056e-07 28 1.045e-05 135 nucleolar part amigo.geneontol...
GO GO:0051297 View Gene Set 1.529e-07 40 1.502e-05 136 centrosome organization amigo.geneontol...
GO GO:0000502 View Gene Set 1.797e-07 63 1.753e-05 137 proteasome complex amigo.geneontol...
GO GO:0031396 View Gene Set 2.004e-07 121 1.94e-05 138 regulation of protein ubiquitination amigo.geneontol...
GO GO:0043189 View Gene Set 3.902e-07 15 3.75e-05 139 H4/H2A histone acetyltransferase complex amigo.geneontol...
GO GO:0006626 View Gene Set 5.312e-07 32 5.033e-05 140 protein targeting to mitochondrion amigo.geneontol...
GO GO:0070585 View Gene Set 5.312e-07 32 5.033e-05 140 protein localization in mitochondrion amigo.geneontol...
GO GO:0050000 View Gene Set 5.958e-07 17 5.566e-05 142 chromosome localization amigo.geneontol...
GO GO:0051303 View Gene Set 5.958e-07 17 5.566e-05 142 establishment of chromosome localization amigo.geneontol...
GO GO:0030532 View Gene Set 8.132e-07 32 7.545e-05 144 small nuclear ribonucleoprotein complex amigo.geneontol...
GO GO:0071103 View Gene Set 8.856e-07 140 8.16e-05 145 DNA conformation change amigo.geneontol...
GO GO:0043234 View Gene Set 9.284e-07 2680 8.495e-05 146 protein complex amigo.geneontol...
GO GO:0015030 View Gene Set 9.365e-07 43 8.508e-05 147 Cajal body amigo.geneontol...
GO GO:0035267 View Gene Set 9.425e-07 14 8.508e-05 147 NuA4 histone acetyltransferase complex amigo.geneontol...
GO GO:0000940 View Gene Set 9.704e-07 12 8.701e-05 149 outer kinetochore of condensed chromosome amigo.geneontol...
GO GO:0016741 View Gene Set 1.222e-06 179 0.0001089 150 transferase activity transferring one-carbon groups amigo.geneontol...
GO GO:0003735 View Gene Set 1.418e-06 158 0.0001254 151 structural constituent of ribosome amigo.geneontol...
GO GO:0044454 View Gene Set 1.619e-06 139 0.0001423 152 nuclear chromosome part amigo.geneontol...
GO GO:0008168 View Gene Set 1.669e-06 176 0.0001458 153 methyltransferase activity amigo.geneontol...
GO GO:0008094 View Gene Set 1.686e-06 61 0.0001463 154 DNA-dependent ATPase activity amigo.geneontol...
GO GO:0044429 View Gene Set 1.933e-06 619 0.0001666 155 mitochondrial part amigo.geneontol...
GO GO:0016569 View Gene Set 1.989e-06 165 0.0001703 156 covalent chromatin modification amigo.geneontol...
GO GO:0009451 View Gene Set 2.047e-06 51 0.0001735 157 RNA modification amigo.geneontol...
GO GO:0033279 View Gene Set 2.052e-06 121 0.0001735 157 ribosomal subunit amigo.geneontol...
GO GO:0034621 View Gene Set 2.109e-06 458 0.0001772 159 cellular macromolecular complex subunit organization amigo.geneontol...
GO GO:0003678 View Gene Set 2.626e-06 44 0.0002193 160 DNA helicase activity amigo.geneontol...
GO GO:0005813 View Gene Set 2.733e-06 166 0.0002268 161 centrosome amigo.geneontol...
GO GO:0000123 View Gene Set 3.017e-06 50 0.0002488 162 histone acetyltransferase complex amigo.geneontol...
GO GO:0006473 View Gene Set 3.457e-06 61 0.0002833 163 protein amino acid acetylation amigo.geneontol...
GO GO:0006325 View Gene Set 4.077e-06 425 0.0003301 164 chromatin organization amigo.geneontol...
GO GO:0016818 View Gene Set 4.067e-06 765 0.0003301 164 hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides amigo.geneontol...
GO GO:0016570 View Gene Set 4.401e-06 162 0.0003542 166 histone modification amigo.geneontol...
GO GO:0016568 View Gene Set 4.912e-06 324 0.0003915 167 chromatin modification amigo.geneontol...
GO GO:0000794 View Gene Set 4.923e-06 52 0.0003915 167 condensed nuclear chromosome amigo.geneontol...
GO GO:0016817 View Gene Set 4.975e-06 769 0.0003933 169 hydrolase activity acting on acid anhydrides amigo.geneontol...
GO GO:0016604 View Gene Set 5.954e-06 198 0.0004679 170 nuclear body amigo.geneontol...
GO GO:0034622 View Gene Set 6.058e-06 393 0.0004733 171 cellular macromolecular complex assembly amigo.geneontol...
GO GO:0007005 View Gene Set 6.159e-06 139 0.0004784 172 mitochondrion organization amigo.geneontol...
GO GO:0006350 View Gene Set 6.48e-06 2744 0.0005004 173 transcription amigo.geneontol...
GO GO:0016462 View Gene Set 6.567e-06 762 0.0005042 174 pyrophosphatase activity amigo.geneontol...
GO GO:0016573 View Gene Set 6.79e-06 56 0.0005184 175 histone acetylation amigo.geneontol...
GO GO:0004518 View Gene Set 6.929e-06 161 0.000526 176 nuclease activity amigo.geneontol...
GO GO:0043968 View Gene Set 7.212e-06 12 0.0005444 177 histone H2A acetylation amigo.geneontol...
GO GO:0008135 View Gene Set 8.882e-06 86 0.0006666 178 translation factor activity nucleic acid binding amigo.geneontol...
GO GO:0004527 View Gene Set 9.482e-06 57 0.0007077 179 exonuclease activity amigo.geneontol...
GO GO:0033554 View Gene Set 1.171e-05 698 0.0008692 180 cellular response to stress amigo.geneontol...
GO GO:0043543 View Gene Set 1.191e-05 72 0.0008791 181 protein amino acid acylation amigo.geneontol...
GO GO:0003697 View Gene Set 1.238e-05 58 0.000909 182 single-stranded DNA binding amigo.geneontol...
GO GO:0051321 View Gene Set 1.26e-05 115 0.0009201 183 meiotic cell cycle amigo.geneontol...
GO GO:0007126 View Gene Set 1.275e-05 113 0.0009206 184 meiosis amigo.geneontol...
GO GO:0051327 View Gene Set 1.275e-05 113 0.0009206 184 M phase of meiotic cell cycle amigo.geneontol...
GO GO:0017111 View Gene Set 1.283e-05 733 0.0009216 186 nucleoside-triphosphatase activity amigo.geneontol...
GO GO:0006400 View Gene Set 1.305e-05 18 0.0009322 187 tRNA modification amigo.geneontol...
GO GO:0004540 View Gene Set 1.519e-05 66 0.00108 188 ribonuclease activity amigo.geneontol...
GO GO:0000387 View Gene Set 1.614e-05 31 0.001141 189 spliceosomal snRNP assembly amigo.geneontol...
GO GO:0008408 View Gene Set 1.645e-05 27 0.001157 190 3'-5' exonuclease activity amigo.geneontol...
GO GO:0044085 View Gene Set 1.717e-05 1167 0.001195 191 cellular component biogenesis amigo.geneontol...
GO GO:0003743 View Gene Set 1.718e-05 52 0.001195 191 translation initiation factor activity amigo.geneontol...
GO GO:0007080 View Gene Set 1.758e-05 11 0.001215 193 mitotic metaphase plate congression amigo.geneontol...
GO GO:0000428 View Gene Set 1.774e-05 24 0.001215 193 DNA-directed RNA polymerase complex amigo.geneontol...
GO GO:0055029 View Gene Set 1.774e-05 24 0.001215 193 nuclear DNA-directed RNA polymerase complex amigo.geneontol...
GO GO:0007052 View Gene Set 1.869e-05 22 0.001274 196 mitotic spindle organization amigo.geneontol...
GO GO:0060255 View Gene Set 2.207e-05 3411 0.001497 197 regulation of macromolecule metabolic process amigo.geneontol...
GO GO:0010556 View Gene Set 2.313e-05 2901 0.001561 198 regulation of macromolecule biosynthetic process amigo.geneontol...
GO GO:0006284 View Gene Set 2.338e-05 26 0.001569 199 base-excision repair amigo.geneontol...
GO GO:0016796 View Gene Set 2.411e-05 20 0.00161 200 exonuclease activity active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters amigo.geneontol...

Gene Set Collection: Broad.c1.CYTOBAND

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad chr9q34 View Gene Set 6.915e-07 204 0.0002254 1 Genes in cytogenetic band chr9q34 www.broad.mit.e...
Broad chr8q24 View Gene Set 3.763e-05 162 0.004604 2 Genes in cytogenetic band chr8q24 www.broad.mit.e...
Broad chr19p13 View Gene Set 4.905e-05 514 0.004604 2 Genes in cytogenetic band chr19p13 www.broad.mit.e...
Broad chr16p13 View Gene Set 5.649e-05 254 0.004604 2 Genes in cytogenetic band chr16p13 www.broad.mit.e...
Broad chr4p16 View Gene Set 7.675e-05 126 0.005004 5 Genes in cytogenetic band chr4p16 www.broad.mit.e...
Broad chr22q13 View Gene Set 0.0001815 179 0.009864 6 Genes in cytogenetic band chr22q13 www.broad.mit.e...
Broad chr17q25 View Gene Set 0.0002795 172 0.01302 7 Genes in cytogenetic band chr17q25 www.broad.mit.e...

Gene Set Collection: Broad.c2.CGP

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad PUJANA_CHEK2_PCC_NETWORK View Gene Set 3.689e-59 744 8.823e-56 1 Genes constituting the CHEK2-PCC network of transcripts whose expression positively correlates (Pearson correlation coefficient PCC >= 0.4) with that of CHEK2 [Gene ID=11200]. www.broad.mit.e...
Broad KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP View Gene Set 2.934e-58 1180 3.509e-55 2 Genes up-regulated in TC71 and EWS502 cells (Ewing's sarcoma) upon knockdown of the EWSR1-FLII fusion [Gene ID=2130 2314]. www.broad.mit.e...
Broad PUJANA_BRCA1_PCC_NETWORK View Gene Set 1.258e-56 1582 1.003e-53 3 Genes constituting the BRCA1-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA1 [Gene ID=672] across a compendium of normal tissues. www.broad.mit.e...
Broad MANALO_HYPOXIA_DN View Gene Set 9.382e-55 276 5.611e-52 4 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. www.broad.mit.e...
Broad CAIRO_HEPATOBLASTOMA_CLASSES_UP View Gene Set 2.375e-53 577 1.136e-50 5 Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). www.broad.mit.e...
Broad DODD_NASOPHARYNGEAL_CARCINOMA_DN View Gene Set 6.379e-50 1253 2.543e-47 6 Genes down-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. www.broad.mit.e...
Broad KOBAYASHI_EGFR_SIGNALING_24HR_DN View Gene Set 2.672e-43 243 9.132e-41 7 Genes down-regulated in H1975 cells (non-small cell lung cancer NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. www.broad.mit.e...
Broad SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP View Gene Set 3.07e-40 143 9.179e-38 8 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. www.broad.mit.e...
Broad WEI_MYCN_TARGETS_WITH_E_BOX View Gene Set 9.433e-40 757 2.507e-37 9 Genes whose promoters contain E-box motifs and whose expression changed in MYCN-3 cells (neuroblastoma) upon induction of MYCN [Gene ID=4613]. www.broad.mit.e...
Broad ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER View Gene Set 1.282e-39 138 3.068e-37 10 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN View Gene Set 2.409e-38 920 5.238e-36 11 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h. www.broad.mit.e...
Broad PUJANA_BRCA2_PCC_NETWORK View Gene Set 4.25e-36 410 8.471e-34 12 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA2 [Gene ID=675] across a compendium of normal tissues. www.broad.mit.e...
Broad WONG_EMBRYONIC_STEM_CELL_CORE View Gene Set 9.58e-33 331 1.763e-30 13 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. www.broad.mit.e...
Broad BERENJENO_TRANSFORMED_BY_RHOA_UP View Gene Set 1.317e-30 485 2.251e-28 14 Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [Gene ID=387] off plasmid vector. www.broad.mit.e...
Broad TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C View Gene Set 4.65e-30 436 7.415e-28 15 Genes down-regulated in HCT116 cells (colon cancer) upon expression of MIR34B or MIR34C [Gene ID=407041 407042] microRNAs. www.broad.mit.e...
Broad SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 View Gene Set 1.18e-29 435 1.764e-27 16 Cluster 6 of method A: up-regulation of these genes in patients with non???small cell lung cancer (NSCLC) predicts poor survival outcome. www.broad.mit.e...
Broad BENPORATH_CYCLING_GENES View Gene Set 1.013e-27 630 1.425e-25 17 Genes showing cell-cycle stage-specific expression [PMID=12058064]. www.broad.mit.e...
Broad MUELLER_PLURINET View Gene Set 9.463e-27 294 1.258e-24 18 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells embryonical carcinomas and induced pluripotent cells). www.broad.mit.e...
Broad CROONQUIST_IL6_DEPRIVATION_DN View Gene Set 1.664e-26 80 2.095e-24 19 Genes down-regulated in the ANBL-6 cell line (multiple myeloma MM) after withdrawal of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad BENPORATH_PROLIFERATION View Gene Set 3.094e-26 140 3.7e-24 20 Set 'Proliferation Cluster': genes defined in human breast tumor expression data. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN View Gene Set 6.015e-26 832 6.852e-24 21 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h. www.broad.mit.e...
Broad WHITEFORD_PEDIATRIC_CANCER_MARKERS View Gene Set 3.378e-24 92 3.673e-22 22 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. www.broad.mit.e...
Broad WINNEPENNINCKX_MELANOMA_METASTASIS_UP View Gene Set 4.224e-24 152 4.392e-22 23 Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years. www.broad.mit.e...
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP View Gene Set 3.567e-23 180 3.555e-21 24 Genes up-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. www.broad.mit.e...
Broad PUJANA_XPRSS_INT_NETWORK View Gene Set 5.351e-23 164 5.12e-21 25 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200] in a compendium of normal tissues. www.broad.mit.e...
Broad KANG_DOXORUBICIN_RESISTANCE_UP View Gene Set 6.696e-23 53 6.161e-21 26 Genes differentialy expressed in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive. www.broad.mit.e...
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_DN View Gene Set 2.606e-22 96 2.309e-20 27 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668] a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. www.broad.mit.e...
Broad CROONQUIST_NRAS_SIGNALING_DN View Gene Set 1.106e-21 62 9.446e-20 28 Genes down-regulated in ANBL-6 cell line (multiple myeloma MM) expressing a constantly active form of NRAS [Gene ID=4893] off a plasmid vector compared to those grown in the presence of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad VECCHI_GASTRIC_CANCER_EARLY_UP View Gene Set 2.607e-21 408 2.15e-19 29 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. www.broad.mit.e...
Broad BLUM_RESPONSE_TO_SALIRASIB_DN View Gene Set 6.979e-21 332 5.565e-19 30 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. www.broad.mit.e...
Broad FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP View Gene Set 3.805e-20 144 2.936e-18 31 Genes up-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones. www.broad.mit.e...
Broad HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP View Gene Set 1.291e-19 93 9.654e-18 32 Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte. www.broad.mit.e...
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN View Gene Set 3.022e-19 86 2.19e-17 33 Genes down-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP View Gene Set 5.73e-18 589 4.031e-16 34 Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. www.broad.mit.e...
Broad MARKEY_RB1_ACUTE_LOF_DN View Gene Set 8.307e-18 201 5.564e-16 35 Genes down-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. www.broad.mit.e...
Broad CHANG_CYCLING_GENES View Gene Set 8.374e-18 49 5.564e-16 35 Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. www.broad.mit.e...
Broad HORIUCHI_WTAP_TARGETS_DN View Gene Set 1.125e-17 289 7.273e-16 37 Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. www.broad.mit.e...
Broad ZHAN_MULTIPLE_MYELOMA_PR_UP View Gene Set 2.632e-17 43 1.656e-15 38 Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. www.broad.mit.e...
Broad NUYTTEN_EZH2_TARGETS_DN View Gene Set 3.673e-17 859 2.253e-15 39 Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. www.broad.mit.e...
Broad GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN View Gene Set 8.378e-17 148 5.01e-15 40 Genes down-regulated in the A673 cells (Ewing sarcoma) after double knockdown of both FLI1 and DAX1 [Gene ID=2313 190] by RNAi. www.broad.mit.e...
Broad MORI_LARGE_PRE_BII_LYMPHOCYTE_UP View Gene Set 1.397e-16 52 8.151e-15 41 Up-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage. www.broad.mit.e...
Broad PUJANA_BRCA_CENTERED_NETWORK View Gene Set 6.364e-16 92 3.624e-14 42 Genes constituting the BRCA-centered network (BCN). www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_3_UP View Gene Set 1.318e-15 314 7.332e-14 43 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. www.broad.mit.e...
Broad KAUFFMANN_MELANOMA_RELAPSE_UP View Gene Set 1.487e-15 57 8.085e-14 44 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_24HR_UP View Gene Set 2.496e-15 537 1.327e-13 45 Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. www.broad.mit.e...
Broad GRADE_COLON_CANCER_UP View Gene Set 2.945e-15 711 1.531e-13 46 Up-regulated genes in colon carcinoma tumors compared to the matched normal mucosa samples. www.broad.mit.e...
Broad BASAKI_YBX1_TARGETS_UP View Gene Set 4.037e-15 279 2.055e-13 47 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [Gene ID=4904] knockdown by RNAi. www.broad.mit.e...
Broad AMUNDSON_GAMMA_RADIATION_RESPONSE View Gene Set 4.784e-15 36 2.384e-13 48 Genes down-regulated across the entire panel of NCI-60 cell lines in response to gamma radiation. www.broad.mit.e...
Broad FOURNIER_ACINAR_DEVELOPMENT_LATE_2 View Gene Set 5.966e-15 265 2.912e-13 49 Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. www.broad.mit.e...
Broad PUJANA_ATM_PCC_NETWORK View Gene Set 8.958e-15 1375 4.285e-13 50 Genes constituting the ATM-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of ATM [Gene ID=472] across a compendium of normal tissues. www.broad.mit.e...
Broad LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN View Gene Set 1.601e-14 158 7.511e-13 51 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. www.broad.mit.e...
Broad FARMER_BREAST_CANCER_CLUSTER_2 View Gene Set 2.44e-14 33 1.122e-12 52 Cluster 2: selected proliferation and 8q amplicon genes clustered together across breast cancer samples. www.broad.mit.e...
Broad CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN View Gene Set 5.463e-14 639 2.466e-12 53 Genes down-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [Gene ID=5371 5914] compared to normal promyeloblasts. www.broad.mit.e...
Broad ODONNELL_TFRC_TARGETS_DN View Gene Set 1.073e-13 131 4.679e-12 54 Genes dpwn-regulated in P493-6 cells (B lymphocyte) upon knockdown of TFRC [Gene ID=7037] by RNAi. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPAIR_GENES View Gene Set 1.076e-13 205 4.679e-12 54 Genes involved in DNA repair compiled manually by the authors. www.broad.mit.e...
Broad FUJII_YBX1_TARGETS_DN View Gene Set 1.121e-13 139 4.789e-12 56 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [Gene ID=4904] by RNAi. www.broad.mit.e...
Broad FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN View Gene Set 1.292e-13 43 5.421e-12 57 Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen raloxifene or ICI 182780 but not by estradiol [PubChem=44959 5035 3478439 5757]. www.broad.mit.e...
Broad GARY_CD5_TARGETS_DN View Gene Set 3.174e-13 415 1.309e-11 58 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [Gene ID=921] off a plasmid vector. www.broad.mit.e...
Broad PAL_PRMT5_TARGETS_UP View Gene Set 3.551e-13 178 1.44e-11 59 Genes up-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [Gene ID=10419] by RNAi. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP View Gene Set 1.568e-12 53 6.25e-11 60 The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [Gene ID=672] compared to those with the wild type allele. www.broad.mit.e...
Broad MITSIADES_RESPONSE_TO_APLIDIN_DN View Gene Set 2.641e-12 241 1.036e-10 61 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164] a marine-derived compound with potential anti-cancer properties. www.broad.mit.e...
Broad MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN View Gene Set 5.815e-12 53 2.244e-10 62 Genes commonly down-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [Gene ID=595 1019]. www.broad.mit.e...
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP View Gene Set 6.065e-12 184 2.303e-10 63 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3 defined by unsupervised clustering. www.broad.mit.e...
Broad TARTE_PLASMA_CELL_VS_PLASMABLAST_DN View Gene Set 9.754e-12 303 3.646e-10 64 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. www.broad.mit.e...
Broad MOOTHA_MITOCHONDRIA View Gene Set 1.783e-11 433 6.561e-10 65 Mitochondrial genes www.broad.mit.e...
Broad YU_MYC_TARGETS_UP View Gene Set 1.883e-11 37 6.825e-10 66 Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [Gene ID=4609]. www.broad.mit.e...
Broad WELCSH_BRCA1_TARGETS_1_DN View Gene Set 2.061e-11 124 7.359e-10 67 Upregulated by induction of exogenous BRCA1 in EcR-293 cells www.broad.mit.e...
Broad DANG_MYC_TARGETS_UP View Gene Set 2.443e-11 127 8.595e-10 68 Genes up-regulated by MYC [Gene ID=4609] and whose promoters are bound by MYC according to MYC Target Gene Database. www.broad.mit.e...
Broad LEE_EARLY_T_LYMPHOCYTE_UP View Gene Set 4.314e-11 80 1.496e-09 69 Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. www.broad.mit.e...
Broad REN_BOUND_BY_E2F View Gene Set 4.453e-11 47 1.521e-09 70 Genes whose promoters were bound by E2F1 [Gene ID=1869] and E2F4 [Gene ID=1874] in the primary fibroblasts WI-38 by ChIP on chip assay. www.broad.mit.e...
Broad ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN View Gene Set 4.795e-11 42 1.615e-09 71 Genes down-regulated in P493-6 cells (B lymphocyte) by MYC [Gene ID=4609] and up-regulated by RNAi knockdown of TFRC [Gene ID=7037]. www.broad.mit.e...
Broad FURUKAWA_DUSP6_TARGETS_PCI35_DN View Gene Set 5.62e-11 66 1.867e-09 72 Genes down-regulated in PCI-35 cells (pancreatic cancer lack endogenous DUSP6 [Gene ID=1848]) upon expression of DUSP6 off an adenoviral vector. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM View Gene Set 6.708e-11 154 2.198e-09 73 Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] and down-regulated by the combination of MYC and serum. www.broad.mit.e...
Broad MORI_IMMATURE_B_LYMPHOCYTE_DN View Gene Set 7.385e-11 52 2.387e-09 74 Down-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the immature B stage. www.broad.mit.e...
Broad RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN View Gene Set 1.746e-10 351 5.568e-09 75 Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. www.broad.mit.e...
Broad CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP View Gene Set 2.392e-10 135 7.528e-09 76 Genes up-regulated in CD4+ [Gene ID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360]. www.broad.mit.e...
Broad BIDUS_METASTASIS_UP View Gene Set 3.56e-10 203 1.106e-08 77 Genes up-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases. www.broad.mit.e...
Broad SCHUHMACHER_MYC_TARGETS_UP View Gene Set 3.746e-10 68 1.149e-08 78 Genes up-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [Gene ID=4609]. www.broad.mit.e...
Broad MOOTHA_HUMAN_MITODB_6_2002 View Gene Set 1.177e-09 420 3.564e-08 79 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPLICATION_GENES View Gene Set 1.406e-09 128 4.204e-08 80 Genes involved in DNA replication compiled manually by the authors. www.broad.mit.e...
Broad SONG_TARGETS_OF_IE86_CMV_PROTEIN View Gene Set 1.48e-09 49 4.37e-08 81 Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector. www.broad.mit.e...
Broad GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN View Gene Set 1.51e-09 51 4.405e-08 82 Genes from the turquoise module which are down-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphocholine (oxPAPC). www.broad.mit.e...
Broad RUIZ_TNC_TARGETS_DN View Gene Set 1.615e-09 138 4.655e-08 83 Genes down-regulated in T98G cells (glioblastoma) by TNC [Gene ID=3371]. www.broad.mit.e...
Broad LY_AGING_OLD_DN View Gene Set 1.774e-09 47 5.052e-08 84 Genes up-regulated in fibroblasts from old individuals compared to those from young donors. www.broad.mit.e...
Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP View Gene Set 1.938e-09 135 5.454e-08 85 Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation high levels of serum AFP [Gene ID=174] and chromosomal instability. www.broad.mit.e...
Broad WU_APOPTOSIS_BY_CDKN1A_VIA_TP53 View Gene Set 3.498e-09 36 9.731e-08 86 Genes downstream of both CDKN1A and TP53 [Gene ID=1026 7157] in 2774qw1 cells (ovarian cancer). www.broad.mit.e...
Broad RHODES_UNDIFFERENTIATED_CANCER View Gene Set 3.581e-09 60 9.846e-08 87 Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer based on the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad LY_AGING_MIDDLE_DN View Gene Set 4.36e-09 15 1.185e-07 88 Genes down-regulated in fibroblasts from middle-age individuals compared to those from the young donors. www.broad.mit.e...
Broad EGUCHI_CELL_CYCLE_RB1_TARGETS View Gene Set 1.153e-08 19 3.099e-07 89 RB1 [Gene ID=5925] target genes involved in cell cycle regulation: genes down-regulated by doxorubicin [PubChem=31703] only in cells expressing RB1. www.broad.mit.e...
Broad GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN View Gene Set 3.655e-08 308 9.713e-07 90 Genes down-regulated in non-metastatic breast cancer tumors having type 1 amplification in the 20q13 region; involves ZNF217 [Gene ID=7764] locus only. www.broad.mit.e...
Broad GRADE_COLON_AND_RECTAL_CANCER_UP View Gene Set 4.369e-08 213 1.149e-06 91 Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. www.broad.mit.e...
Broad PENG_GLUTAMINE_DEPRIVATION_DN View Gene Set 4.479e-08 84 1.165e-06 92 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. www.broad.mit.e...
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP View Gene Set 4.818e-08 469 1.239e-06 93 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. www.broad.mit.e...
Broad WEST_ADRENOCORTICAL_TUMOR_UP View Gene Set 5.737e-08 283 1.46e-06 94 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. www.broad.mit.e...
Broad DANG_BOUND_BY_MYC View Gene Set 6.736e-08 1045 1.696e-06 95 Genes whose promoters are bound by MYC [Gene ID=4609] according to MYC Target Gene Database. www.broad.mit.e...
Broad FINETTI_BREAST_CANCER_KINOME_RED View Gene Set 8.629e-08 15 2.128e-06 96 Genes in the red cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. www.broad.mit.e...
Broad FINETTI_BREAST_CANCER_BASAL_VS_LUMINAL View Gene Set 8.629e-08 15 2.128e-06 96 Protein kinases distinguishing between basal and luminal A subtypes of breast cancer. www.broad.mit.e...
Broad LE_EGR2_TARGETS_UP View Gene Set 1.817e-07 100 4.39e-06 98 Genes up-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [Gene ID=1959]. www.broad.mit.e...
Broad ZHANG_BREAST_CANCER_PROGENITORS_UP View Gene Set 1.809e-07 370 4.39e-06 98 Genes changed in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. www.broad.mit.e...
Broad DAIRKEE_TERT_TARGETS_UP View Gene Set 2.274e-07 317 5.44e-06 100 Genes up-regulated in non-spontaneously immortalizing (NSI) primary breast cancer tumor cultures upon expression of TERT [Gene ID=7015] off a retroviral vector. www.broad.mit.e...
Broad ELVIDGE_HYPOXIA_DN View Gene Set 2.951e-07 136 6.988e-06 101 Genes down-regulated in MCF7 cells (breast cancer) under hypoxia conditions. www.broad.mit.e...
Broad KUMAMOTO_RESPONSE_TO_NUTLIN_3A_DN View Gene Set 3.104e-07 10 7.278e-06 102 Genes down-regulated in response to nutlin-3a [PubChem=216345] an inhibitor of MDM2 [Gene ID=4193] in skin fibroblast cultures after knockdown of TP53 [Gene ID=7157] by RNAi. www.broad.mit.e...
Broad CHANG_CORE_SERUM_RESPONSE_UP View Gene Set 4.025e-07 66 9.348e-06 103 Up-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. www.broad.mit.e...
Broad BENPORATH_ES_1 View Gene Set 9.46e-07 367 2.176e-05 104 Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies. www.broad.mit.e...
Broad MENSSEN_MYC_TARGETS View Gene Set 1.076e-06 16 2.45e-05 105 Genes up-regulated by adenoviral expression of c-MYC [Gene ID=4609] in HUVEC cells (umbilical vein endothelium). www.broad.mit.e...
Broad CAFFAREL_RESPONSE_TO_THC_DN View Gene Set 1.314e-06 25 2.965e-05 106 Genes down-regulated in EVSA-T cells (breast cancer) treated THC (delta-9-tetrahydrocannabinol) [PubChem=6610319]. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN View Gene Set 1.367e-06 46 3.056e-05 107 Cluster 6: genes down-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] in combination with serum but not affected by serum alone; they are also up-regulated by MYC alone. www.broad.mit.e...
Broad SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN View Gene Set 1.579e-06 22 3.497e-05 108 Cell cycle genes changed in H1299 cells (lung cancer) after overexpression of either P53 [Gene ID=7157] or P73 [Gene ID=7161]. www.broad.mit.e...
Broad SCHLOSSER_MYC_AND_SERUM_RESPONSE_SYNERGY View Gene Set 1.643e-06 31 3.606e-05 109 Cluster 3: genes strongly up-regulated in B493-6 cells (B lymphocytes) by a combination of MYC [Gene ID=4609] and serum but not by each of them alone. www.broad.mit.e...
Broad MONTERO_THYROID_CANCER_POOR_SURVIVAL_UP View Gene Set 1.8e-06 10 3.914e-05 110 Up-regulated genes predicting poor survival of patients with thyroid carcinoma. www.broad.mit.e...
Broad MATTIOLI_MGUS_VS_PCL View Gene Set 2.187e-06 109 4.682e-05 111 Genes changed in MGUS (monoclonal gammopathy of undetermined significance) compared to PCL (plasma cell leukemia) samples. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_LIT_INT_NETWORK View Gene Set 2.192e-06 100 4.682e-05 111 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200]; the interactions were manually curated from the literature. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 View Gene Set 2.414e-06 131 5.111e-05 113 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 14. www.broad.mit.e...
Broad SEMBA_FHIT_TARGETS_DN View Gene Set 2.572e-06 10 5.397e-05 114 Genes down-regulated in H1299 cells (non-small cell lung cancer NSCLC) expressing the Y144F mutant form of FHIT [Gene ID=2272]. www.broad.mit.e...
Broad SMID_BREAST_CANCER_LUMINAL_A_DN View Gene Set 3.043e-06 17 6.329e-05 115 Genes down-regulated in the luminal A subtype of breast cancer. www.broad.mit.e...
Broad TANG_SENESCENCE_TP53_TARGETS_DN View Gene Set 3.168e-06 40 6.533e-05 116 Genes down-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [Gene ID=7157] by GSE56 polypeptide. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP View Gene Set 3.37e-06 45 6.89e-05 117 Cluster 5: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] alone or in combination with serum but not by serum alone. www.broad.mit.e...
Broad DANG_REGULATED_BY_MYC_UP View Gene Set 3.405e-06 65 6.902e-05 118 Genes up-regulated by MYC [Gene ID=4609] according to the MYC Target Gene Database. www.broad.mit.e...
Broad RIZ_ERYTHROID_DIFFERENTIATION View Gene Set 6.235e-06 71 0.0001253 119 Selected gradually up-regulated genes in the TLX1 [Gene ID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). www.broad.mit.e...
Broad SU_TESTIS View Gene Set 6.867e-06 75 0.0001369 120 Genes up-regulated specifically in human testis tissue. www.broad.mit.e...
Broad WAKASUGI_HAVE_ZNF143_BINDING_SITES View Gene Set 7.875e-06 55 0.0001544 121 DNA repair genes whose promoters contain putative ZNF143 [Gene ID=7702] binding sites. www.broad.mit.e...
Broad IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR View Gene Set 7.871e-06 100 0.0001544 121 Genes in the expression cluster 'Early Progenitors Shared': up-regulated in hematopoietic progenitors from adult bone marrow and from fetal liver. www.broad.mit.e...
Broad ZHANG_RESPONSE_TO_CANTHARIDIN_DN View Gene Set 8.955e-06 60 0.0001742 123 Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. www.broad.mit.e...
Broad WONG_PROTEASOME_GENE_MODULE View Gene Set 9.8e-06 46 0.000189 124 Genes that comprise the proteasome gene module www.broad.mit.e...
Broad MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN View Gene Set 1.223e-05 121 0.0002341 125 Genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [Gene ID=23495]. www.broad.mit.e...
Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP View Gene Set 1.819e-05 87 0.0003453 126 Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. www.broad.mit.e...
Broad NADERI_BREAST_CANCER_PROGNOSIS_UP View Gene Set 2.246e-05 37 0.000423 127 Up-regulated genes in the breast cancer prognostic signature of 70 genes that significantly correlated with survival. www.broad.mit.e...
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G23_UP View Gene Set 2.299e-05 52 0.0004296 128 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G23 defined by unsupervised clustering. www.broad.mit.e...
Broad HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP View Gene Set 3.569e-05 59 0.0006618 129 Genes up-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [Gene ID=3205 4211]. www.broad.mit.e...
Broad GOLDRATH_ANTIGEN_RESPONSE View Gene Set 3.87e-05 315 0.0007122 130 Genes up-regulated at the peak of an antigen response of naive CD8+ [Gene ID=925 926] T-cells. www.broad.mit.e...
Broad GEORGES_CELL_CYCLE_MIR192_TARGETS View Gene Set 5.174e-05 59 0.0009447 131 Experimentally validated direct targets of MIR192 [Gene ID=406967] microRNA; MIR192 caused cell cycle arrest in HCT116 cells (colon cancer). www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 View Gene Set 7.193e-05 165 0.001304 132 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. www.broad.mit.e...
Broad ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN View Gene Set 8.416e-05 61 0.001514 133 Genes down-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562]. www.broad.mit.e...
Broad BENPORATH_MYC_TARGETS_WITH_EBOX View Gene Set 9.135e-05 229 0.001631 134 Set 'Myc targets1': targets of c-Myc [Gene ID=4609] identified by ChIP on chip in cultured cell lines focusing on E-box???containing genes; high affinity bound subset www.broad.mit.e...
Broad BENPORATH_MYC_MAX_TARGETS View Gene Set 9.567e-05 768 0.001695 135 Set 'Myc targets2': targets of c-Myc [Gene ID=4609] and Max [Gene ID=4149] identified by ChIP on chip in a Burkitt???s lymphoma cell line; overlap set. www.broad.mit.e...
Broad BHATTACHARYA_EMBRYONIC_STEM_CELL View Gene Set 0.0001005 76 0.001768 136 The 'stemnes' signature: genes up-regulated and common to 6 human embryonic stem cell lines tested. www.broad.mit.e...
Broad ELVIDGE_HIF1A_TARGETS_UP View Gene Set 0.0001076 64 0.001871 137 Genes up-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [Gene ID=3091] by RNAi. www.broad.mit.e...
Broad SHEPARD_BMYB_TARGETS View Gene Set 0.0001079 60 0.001871 137 Human orthologs of BMYB [Gene ID=4605] target genes in zebra fish identified as commonly changed in the BMYB loss of function mutant crb ('crush and burn') and after knockdown of BMYB by morpholino. www.broad.mit.e...
Broad WONG_MITOCHONDRIA_GENE_MODULE View Gene Set 0.0001115 208 0.001918 139 Genes that comprise the mitochondria gene module www.broad.mit.e...
Broad FOURNIER_ACINAR_DEVELOPMENT_LATE_DN View Gene Set 0.0001241 21 0.002121 140 Genes down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. www.broad.mit.e...
Broad FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN View Gene Set 0.000145 76 0.00246 141 Top 100 genes positively (UP) and negatively (DN) associated with T-cell acute lymphoblastic leukemia MLL T-ALL) expressing MLL-ENL fusion [Gene ID=4297 4298]. www.broad.mit.e...
Broad NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON View Gene Set 0.0001501 150 0.002528 142 Genes within amplicon 8q23-q24 identified in a copy number alterations study of 191 breast tumor samples. www.broad.mit.e...
Broad MOOTHA_PGC View Gene Set 0.0001613 329 0.002698 143 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [Gene ID=10891] off an adenoviral vector. www.broad.mit.e...
Broad RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP View Gene Set 0.0001822 36 0.003006 144 Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: moderately vs poorly differentiated tumors. www.broad.mit.e...
Broad RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_DN View Gene Set 0.0001822 36 0.003006 144 Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: moderately vs poorly differentiated tumors. www.broad.mit.e...
Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN View Gene Set 0.0001906 155 0.003123 146 Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. www.broad.mit.e...
Broad RIZ_ERYTHROID_DIFFERENTIATION_CCNE1 View Gene Set 0.0002 38 0.003254 147 Selected gradually up-regulated genes whose expression profile follows that of CCNE1 [Gene ID=898] in the TLX1 [Gene ID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). www.broad.mit.e...
Broad MEINHOLD_OVARIAN_CANCER_LOW_GRADE_DN View Gene Set 0.000326 18 0.005268 148 Genes down-regulated in low grade (LMP and G1) serous ovarian carcinomas vs the higher grade invasive tumors (G2 and G3). www.broad.mit.e...
Broad RHODES_CANCER_META_SIGNATURE View Gene Set 0.000398 54 0.006346 149 Genes commonly up-regulated in cancer relative to normal tissue according to the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad CHUANG_OXIDATIVE_STRESS_RESPONSE_DN View Gene Set 0.0003957 10 0.006346 149 Genes down-regulated in MCF7 cells (breast cancer) after treatment with the oxydants: hydrogen peroxyde menadione and t-butyl hydroperoxyde [PubChem=784 4055 6410]. www.broad.mit.e...
Broad CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN View Gene Set 0.0004178 81 0.006619 151 Genes down-regulated in ANBL-6 cell line (multiple myeloma MM) expressing an activated form of NRAS [Gene ID=4893] off a plasmid vector compared to those co-cultured with bone marrow stromal cells. www.broad.mit.e...
Broad NAKAMURA_CANCER_MICROENVIRONMENT_DN View Gene Set 0.0004263 45 0.006708 152 Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. www.broad.mit.e...
Broad LEE_METASTASIS_AND_RNA_PROCESSING_UP View Gene Set 0.0004377 15 0.006842 153 Components of RNA post-transcriptional modification machinery up-regulated in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [Gene ID=4830]. www.broad.mit.e...
Broad GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP View Gene Set 0.0004469 86 0.006941 154 Genes up-regulated in quiescent (G0) CD34+ [Gene ID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the quiescent cells from normal donors. www.broad.mit.e...
Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP View Gene Set 0.0004498 269 0.006941 155 Genes up-regulated in nsopharyngeal carcinoma relative to the normal tissue. www.broad.mit.e...
Broad NIKOLSKY_BREAST_CANCER_7P22_AMPLICON View Gene Set 0.0005243 36 0.008039 156 Genes within amplicon 7p22 identified in a copy number alterations study of 191 breast tumor samples. www.broad.mit.e...
Broad PENG_LEUCINE_DEPRIVATION_DN View Gene Set 0.000558 50 0.008502 157 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. www.broad.mit.e...
Broad GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN View Gene Set 0.0005641 160 0.00854 158 Genes down-regulated in metastatic breast cancer tumors having type 2 amplification in the 20q13 region; involves MYBL2 STK6 and ZNF217 [Gene ID=4605 6790 7764] www.broad.mit.e...
Broad GOLDRATH_HOMEOSTATIC_PROLIFERATION View Gene Set 0.0006657 154 0.009952 159 Up-regulated in CD8+ [Gene ID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population. www.broad.mit.e...
Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP View Gene Set 0.000662 359 0.009952 159 The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. www.broad.mit.e...
Broad RAMALHO_STEMNESS_UP View Gene Set 0.0006988 192 0.01038 161 Genes enriched in embryonic neural and hematopoietic stem cells. www.broad.mit.e...
Broad BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP View Gene Set 0.0007136 190 0.01054 162 Genes up-regulated in medullary breast cancer (MBC) relative to ductal breast cancer (DBD). www.broad.mit.e...
Broad MATTIOLI_MGUS_VS_MULTIPLE_MYELOMA View Gene Set 0.0007319 16 0.01068 163 Genes distinguishing between MGUS (monoclonal gammopathy of undetermined significance) and multiple myeloma (MM) samples. www.broad.mit.e...
Broad LY_AGING_PREMATURE_DN View Gene Set 0.0007296 24 0.01068 163 Genes down-regulated in fibroblasts from patients with Hutchinson-Gilford progeria (premature aging) compared to those from normal young individuals. www.broad.mit.e...
Broad MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN View Gene Set 0.0007383 212 0.0107 165 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. www.broad.mit.e...
Broad GAJATE_RESPONSE_TO_TRABECTEDIN_DN View Gene Set 0.001058 16 0.01524 166 Genes down-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199]. www.broad.mit.e...
Broad BILD_MYC_ONCOGENIC_SIGNATURE View Gene Set 0.001105 187 0.01583 167 Genes selected in supervised analyses to discriminate cells expressing c-Myc [Gene ID=4609] from control cells expressing GFP. www.broad.mit.e...
Broad CAMPS_COLON_CANCER_COPY_NUMBER_UP View Gene Set 0.001125 75 0.01601 168 Genes from chromosomal copy number gains in a panel of 51 primary colon carcinoma samples. www.broad.mit.e...
Broad PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP View Gene Set 0.001171 175 0.01658 169 Up-regulated genes in head and neck cancer compared to cervical carcinoma samples. www.broad.mit.e...
Broad VANTVEER_BREAST_CANCER_METASTASIS_DN View Gene Set 0.001216 104 0.01701 170 Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). www.broad.mit.e...
Broad BROWNE_HCMV_INFECTION_14HR_UP View Gene Set 0.00121 150 0.01701 170 Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not up-regulated at the previous time point 12 h. www.broad.mit.e...
Broad DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 View Gene Set 0.001264 111 0.01758 172 'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757 6623] response of epithelial cell cultures from patients at high risk of breast cancer. www.broad.mit.e...
Broad SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP View Gene Set 0.001328 16 0.01837 173 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial basal-like phenotype) confluency. www.broad.mit.e...
Broad AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP View Gene Set 0.0016 288 0.022 174 Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens. www.broad.mit.e...
Broad SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP View Gene Set 0.002199 72 0.03005 175 Genes up-regulated in head and neck squamous cell carcinoma (HNSCC) samples positive for HPV compared to the HPV-negative tumors. www.broad.mit.e...
Broad WILCOX_PRESPONSE_TO_ROGESTERONE_UP View Gene Set 0.00226 143 0.03071 176 Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_1_DN View Gene Set 0.002495 368 0.03372 177 Genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. www.broad.mit.e...
Broad NAGY_PCAF_COMPONENTS_HUMAN View Gene Set 0.00254 5 0.03394 178 Composition of the 2 MDa human PCAF complex. www.broad.mit.e...
Broad RASHI_RESPONSE_TO_IONIZING_RADIATION_4 View Gene Set 0.002536 48 0.03394 178 Cluster 4: genes repressed by ionizing radiation regardless of ATM [Gene ID=472] status. www.broad.mit.e...
Broad GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_DN View Gene Set 0.002708 24 0.03598 180 Genes from the green module which are down-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). www.broad.mit.e...
Broad LIN_APC_TARGETS View Gene Set 0.002729 52 0.03606 181 Genes up-regulated by forced expression of APC [Gene ID=324] in the APC-deficient SW480 cell line (colon cancer). www.broad.mit.e...
Broad ZHAN_MULTIPLE_MYELOMA_SUBGROUPS View Gene Set 0.0028 28 0.0368 182 Top genes up-regulated in MM4 vs MM1 subgroup of multiple myeloma samples. www.broad.mit.e...
Broad HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_UP View Gene Set 0.002951 8 0.03857 183 Genes up-regulated in bone marrow hematopoietic stem cells (HSC CD34+ [Gene ID=947]) from patients with high risk of myelodysplastic syndrome (MDS) compared with healthy controls. www.broad.mit.e...
Broad PODAR_RESPONSE_TO_ADAPHOSTIN_DN View Gene Set 0.003023 17 0.0393 184 Down-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042] a tyrosine kinase inhibitor with anticancer properties. www.broad.mit.e...
Broad MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN View Gene Set 0.003319 42 0.04291 185 Genes down-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI [Gene ID=23495]. www.broad.mit.e...
Broad PENG_RAPAMYCIN_RESPONSE_DN View Gene Set 0.003357 69 0.04306 186 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 View Gene Set 0.003367 93 0.04306 186 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. www.broad.mit.e...
Broad HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY View Gene Set 0.003583 16 0.04524 188 Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with trisomy of chromosome 12. www.broad.mit.e...
Broad GALE_APL_WITH_FLT3_MUTATED_UP View Gene Set 0.003593 52 0.04524 188 Genes up-regulated in acute promyelocytic leukemia (APL) patients with mutated FLT3 [Gene ID=2322]. www.broad.mit.e...
Broad FAELT_B_CLL_WITH_VH3_21_UP View Gene Set 0.003584 44 0.04524 188 Genes changed in samples from B-CLL (B-cell chronic lymphocytic leukemia) using the immunoglobulin heavy chain VH3-21 gene. www.broad.mit.e...
Broad LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP View Gene Set 0.003692 168 0.04599 191 Genes with copy number gains in primary neuroblastoma tumors. www.broad.mit.e...
Broad OHASHI_AURKB_TARGETS View Gene Set 0.003688 8 0.04599 191 Candidate substrate proteins of AURKB [Gene ID=9212]. www.broad.mit.e...
Broad ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_DN View Gene Set 0.003741 17 0.04637 193 Genes in discrete regions of loss within 16q region detected in individual invasive breast cancer tumors. www.broad.mit.e...
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP View Gene Set 0.003761 44 0.04638 194 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G123 defined by unsupervised clustering. www.broad.mit.e...
Broad MORI_MATURE_B_LYMPHOCYTE_DN View Gene Set 0.003873 56 0.0475 195 Down-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the mature B www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.BIOCARTA

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad BIOCARTA_RANMS_PATHWAY View Gene Set 5.386e-07 10 0.0001169 1 Role of Ran in mitotic spindle regulation www.broad.mit.e...
Broad BIOCARTA_ATRBRCA_PATHWAY View Gene Set 9.81e-06 21 0.001064 2 Role of BRCA1 BRCA2 and ATR in Cancer Susceptibility www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.KEGG

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad KEGG_SPLICEOSOME View Gene Set 1.366e-15 118 2.541e-13 1 Spliceosome www.broad.mit.e...
Broad KEGG_RNA_DEGRADATION View Gene Set 2.32e-08 59 1.438e-06 2 RNA degradation www.broad.mit.e...
Broad KEGG_CELL_CYCLE View Gene Set 1.569e-08 128 1.438e-06 2 Cell cycle www.broad.mit.e...
Broad KEGG_PYRIMIDINE_METABOLISM View Gene Set 2.149e-07 98 9.992e-06 4 Pyrimidine metabolism www.broad.mit.e...
Broad KEGG_PROTEASOME View Gene Set 2.767e-06 48 0.0001029 5 Proteasome www.broad.mit.e...
Broad KEGG_DNA_REPLICATION View Gene Set 2.14e-05 36 0.0006635 6 DNA replication www.broad.mit.e...
Broad KEGG_AMINOACYL_TRNA_BIOSYNTHESIS View Gene Set 2.536e-05 41 0.000674 7 Aminoacyl-tRNA biosynthesis www.broad.mit.e...
Broad KEGG_HOMOLOGOUS_RECOMBINATION View Gene Set 3.122e-05 28 0.0007258 8 Homologous recombination www.broad.mit.e...
Broad KEGG_MISMATCH_REPAIR View Gene Set 5.715e-05 23 0.001181 9 Mismatch repair www.broad.mit.e...
Broad KEGG_BASE_EXCISION_REPAIR View Gene Set 0.0001637 35 0.003045 10 Base excision repair www.broad.mit.e...
Broad KEGG_RNA_POLYMERASE View Gene Set 0.0002165 29 0.003662 11 RNA polymerase www.broad.mit.e...
Broad KEGG_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 0.0004468 44 0.006926 12 Nucleotide excision repair www.broad.mit.e...
Broad KEGG_ONE_CARBON_POOL_BY_FOLATE View Gene Set 0.003711 17 0.0493 13 One carbon pool by folate www.broad.mit.e...
Broad KEGG_OLFACTORY_TRANSDUCTION View Gene Set 0.003497 389 0.0493 13 Olfactory transduction www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.REACTOME

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad REACTOME_CELL_CYCLE_MITOTIC View Gene Set 1.386e-42 306 5.962e-40 1 Genes involved in Cell Cycle Mitotic www.broad.mit.e...
Broad REACTOME_MITOTIC_M_M_G1_PHASES View Gene Set 3.172e-31 157 6.82e-29 2 Genes involved in Mitotic M-M/G1 phases www.broad.mit.e...
Broad REACTOME_MITOTIC_PROMETAPHASE View Gene Set 3.635e-21 92 5.21e-19 3 Genes involved in Mitotic Prometaphase www.broad.mit.e...
Broad REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA View Gene Set 1.843e-19 128 1.981e-17 4 Genes involved in Processing of Capped Intron-Containing Pre-mRNA www.broad.mit.e...
Broad REACTOME_CELL_CYCLE_CHECKPOINTS View Gene Set 1.667e-17 110 1.434e-15 5 Genes involved in Cell Cycle Checkpoints www.broad.mit.e...
Broad REACTOME_GENE_EXPRESSION View Gene Set 2.146e-17 415 1.538e-15 6 Genes involved in Gene Expression www.broad.mit.e...
Broad REACTOME_ELONGATION_AND_PROCESSING_OF_CAPPED_TRANSCRIPTS View Gene Set 4.474e-16 124 2.749e-14 7 Genes involved in Elongation and Processing of Capped Transcripts www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_RNA View Gene Set 9.364e-15 95 5.033e-13 8 Genes involved in Metabolism of RNA www.broad.mit.e...
Broad REACTOME_FORMATION_AND_MATURATION_OF_MRNA_TRANSCRIPT View Gene Set 1.216e-14 142 5.81e-13 9 Genes involved in Formation and Maturation of mRNA Transcript www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING View Gene Set 2.192e-14 97 9.427e-13 10 Genes involved in mRNA Splicing www.broad.mit.e...
Broad REACTOME_G1_S_TRANSITION View Gene Set 8.915e-13 102 3.485e-11 11 Genes involved in G1/S Transition www.broad.mit.e...
Broad REACTOME_G2_M_TRANSITION View Gene Set 6.497e-12 84 2.328e-10 12 Genes involved in G2/M Transition www.broad.mit.e...
Broad REACTOME_REGULATION_OF_APC_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE View Gene Set 5.174e-11 71 1.711e-09 13 Genes involved in Regulation of APC/C activators between G1/S and early anaphase www.broad.mit.e...
Broad REACTOME_G2_M_CHECKPOINTS View Gene Set 9.404e-11 43 2.633e-09 14 Genes involved in G2/M Checkpoints www.broad.mit.e...
Broad REACTOME_HIV_INFECTION View Gene Set 8.994e-11 183 2.633e-09 14 Genes involved in HIV Infection www.broad.mit.e...
Broad REACTOME_S_PHASE View Gene Set 9.799e-11 103 2.633e-09 14 Genes involved in S Phase www.broad.mit.e...
Broad REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A View Gene Set 1.113e-10 63 2.816e-09 17 Genes involved in Cdc20:Phospho-APC/C mediated degradation of Cyclin A www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_DNA View Gene Set 1.211e-10 89 2.892e-09 18 Genes involved in Synthesis of DNA www.broad.mit.e...
Broad REACTOME_M_G1_TRANSITION View Gene Set 1.288e-10 61 2.914e-09 19 Genes involved in M/G1 Transition www.broad.mit.e...
Broad REACTOME_DNA_REPLICATION_PRE_INITIATION View Gene Set 1.916e-10 76 4.119e-09 20 Genes involved in DNA Replication Pre-Initiation www.broad.mit.e...
Broad REACTOME_CENTROSOME_MATURATION View Gene Set 4.431e-10 72 9.074e-09 21 Genes involved in Centrosome maturation www.broad.mit.e...
Broad REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX View Gene Set 6.304e-10 52 1.232e-08 22 Genes involved in CDT1 association with the CDC6:ORC:origin complex www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS View Gene Set 7.61e-10 37 1.423e-08 23 Genes involved in Activation of ATR in response to replication stress www.broad.mit.e...
Broad REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC View Gene Set 3.006e-09 57 5.386e-08 24 Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_MRNA View Gene Set 9.702e-09 45 1.669e-07 25 Genes involved in Metabolism of mRNA www.broad.mit.e...
Broad REACTOME_ORC1_REMOVAL_FROM_CHROMATIN View Gene Set 1.388e-08 63 2.296e-07 26 Genes involved in Orc1 removal from chromatin www.broad.mit.e...
Broad REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING View Gene Set 1.68e-08 50 2.676e-07 27 Genes involved in Chaperonin-mediated protein folding www.broad.mit.e...
Broad REACTOME_DNA_REPAIR View Gene Set 2.243e-08 102 3.325e-07 28 Genes involved in DNA Repair www.broad.mit.e...
Broad REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS View Gene Set 2.226e-08 120 3.325e-07 28 Genes involved in Host Interactions of HIV factors www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRON_CONTAINING_TRANSCRIPT View Gene Set 3.835e-08 42 5.496e-07 30 Genes involved in Transport of Mature mRNA derived from an Intron-Containing Transcript www.broad.mit.e...
Broad REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES View Gene Set 5.704e-08 62 7.912e-07 31 Genes involved in Loss of Nlp from mitotic centrosomes www.broad.mit.e...
Broad REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC View Gene Set 8.132e-08 22 1.093e-06 32 Genes involved in Formation of tubulin folding intermediates by CCT/TriC www.broad.mit.e...
Broad REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 View Gene Set 8.74e-08 48 1.139e-06 33 Genes involved in SCF-beta-TrCP mediated degradation of Emi1 www.broad.mit.e...
Broad REACTOME_SNRNP_ASSEMBLY View Gene Set 9.384e-08 50 1.187e-06 34 Genes involved in snRNP Assembly www.broad.mit.e...
Broad REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE View Gene Set 2.008e-07 90 2.467e-06 35 Genes involved in Late Phase of HIV Life Cycle www.broad.mit.e...
Broad REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC View Gene Set 3.032e-07 28 3.621e-06 36 Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC www.broad.mit.e...
Broad REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE View Gene Set 3.507e-07 43 4.039e-06 37 Genes involved in p53-Independent DNA Damage Response www.broad.mit.e...
Broad REACTOME_REV_MEDIATED_NUCLEAR_EXPORT_OF_HIV1_RNA View Gene Set 3.569e-07 31 4.039e-06 37 Genes involved in Rev-mediated nuclear export of HIV-1 RNA www.broad.mit.e...
Broad REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN View Gene Set 4.071e-07 30 4.489e-06 39 Genes involved in Nuclear import of Rev protein www.broad.mit.e...
Broad REACTOME_HIV_LIFE_CYCLE View Gene Set 4.343e-07 103 4.669e-06 40 Genes involved in HIV Life Cycle www.broad.mit.e...
Broad REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE View Gene Set 1.337e-06 47 1.402e-05 41 Genes involved in Regulation of ornithine decarboxylase (ODC) www.broad.mit.e...
Broad REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY View Gene Set 1.489e-06 19 1.525e-05 42 Genes involved in Post-chaperonin tubulin folding pathway www.broad.mit.e...
Broad REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY View Gene Set 1.548e-06 29 1.548e-05 43 Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery www.broad.mit.e...
Broad REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G View Gene Set 1.613e-06 47 1.577e-05 44 Genes involved in Vif-mediated degradation of APOBEC3G www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_THE_SLBP_INDEPENDENT_MATURE_MRNA View Gene Set 2.446e-06 32 2.337e-05 45 Genes involved in Transport of the SLBP independent Mature mRNA www.broad.mit.e...
Broad REACTOME_STABILIZATION_OF_P53 View Gene Set 2.758e-06 46 2.579e-05 46 Genes involved in Stabilization of p53 www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION View Gene Set 3.026e-06 83 2.769e-05 47 Genes involved in RNA Polymerase II Transcription www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS View Gene Set 3.137e-06 29 2.811e-05 48 Genes involved in Transport of Ribonucleoproteins into the Host Nucleus www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION View Gene Set 4.109e-06 188 3.606e-05 49 Genes involved in Transcription www.broad.mit.e...
Broad REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 View Gene Set 4.419e-06 52 3.801e-05 50 Genes involved in SCF(Skp2)-mediated degradation of p2721 www.broad.mit.e...
Broad REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ View Gene Set 1.013e-05 58 8.545e-05 51 Genes involved in Cyclin E associated events during G1/S transition www.broad.mit.e...
Broad REACTOME_E2F_TRANSCRIPTIONAL_TARGETS_AT_G1_S View Gene Set 1.329e-05 22 0.0001099 52 Genes involved in E2F transcriptional targets at G1/S www.broad.mit.e...
Broad REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION View Gene Set 2.173e-05 20 0.0001763 53 Genes involved in Mitochondrial tRNA aminoacylation www.broad.mit.e...
Broad REACTOME_MRNA_3_END_PROCESSING View Gene Set 2.745e-05 25 0.0002153 54 Genes involved in mRNA 3-end processing www.broad.mit.e...
Broad REACTOME_SIGNALING_BY_WNT View Gene Set 2.753e-05 58 0.0002153 54 Genes involved in Signaling by Wnt www.broad.mit.e...
Broad REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION View Gene Set 2.822e-05 33 0.0002167 56 Genes involved in E2F mediated regulation of DNA replication www.broad.mit.e...
Broad REACTOME_TRNA_AMINOACYLATION View Gene Set 2.884e-05 40 0.0002176 57 Genes involved in tRNA Aminoacylation www.broad.mit.e...
Broad REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES View Gene Set 3.029e-05 11 0.0002246 58 Genes involved in Recruitment of NuMA to mitotic centrosomes www.broad.mit.e...
Broad REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN View Gene Set 3.639e-05 29 0.0002652 59 Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_PROTEINS View Gene Set 3.77e-05 215 0.0002702 60 Genes involved in Metabolism of proteins www.broad.mit.e...
Broad REACTOME_VPR_MEDIATED_NUCLEAR_IMPORT_OF_PICS View Gene Set 5.541e-05 31 0.0003906 61 Genes involved in Vpr-mediated nuclear import of PICs www.broad.mit.e...
Broad REACTOME_INACTIVATION_OF_APC_VIA_DIRECT_INHIBITION_OF_THE_APCOMPLEX View Gene Set 7.05e-05 18 0.000489 62 Genes involved in Inactivation of APC/C via direct inhibition of the APC/C complex www.broad.mit.e...
Broad REACTOME_GLUCOSE_TRANSPORT View Gene Set 8.663e-05 38 0.0005913 63 Genes involved in Glucose transport www.broad.mit.e...
Broad REACTOME_CYCLIN_A1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION View Gene Set 9.143e-05 15 0.0006143 64 Genes involved in Cyclin A1 associated events during G2/M transition www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_COUPLED_NER View Gene Set 9.674e-05 44 0.00064 65 Genes involved in Transcription-coupled NER (TC-NER) www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE View Gene Set 0.0001049 11 0.0006835 66 Genes involved in mRNA Decay by 3' to 5' Exoribonuclease www.broad.mit.e...
Broad REACTOME_EXTENSION_OF_TELOMERES View Gene Set 0.0001111 28 0.0007133 67 Genes involved in Extension of Telomeres www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS View Gene Set 0.0001187 29 0.0007504 68 Genes involved in Association of TriC/CCT with target proteins during biosynthesis www.broad.mit.e...
Broad REACTOME_DNA_STRAND_ELONGATION View Gene Set 0.0001257 31 0.0007831 69 Genes involved in DNA strand elongation www.broad.mit.e...
Broad REACTOME_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 0.0001308 49 0.0008032 70 Genes involved in Nucleotide Excision Repair www.broad.mit.e...
Broad REACTOME_PHOSPHORYLATION_OF_THE_APC View Gene Set 0.0002577 17 0.00156 71 Genes involved in Phosphorylation of the APC/C www.broad.mit.e...
Broad REACTOME_APCDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B View Gene Set 0.0002841 18 0.001697 72 Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX View Gene Set 0.0002939 30 0.001708 73 Genes involved in Activation of the pre-replicative complex www.broad.mit.e...
Broad REACTOME_DEADENYLATION_OF_MRNA View Gene Set 0.0002936 21 0.001708 73 Genes involved in Deadenylation of mRNA www.broad.mit.e...
Broad REACTOME_CITRIC_ACID_CYCLE View Gene Set 0.0003003 19 0.001722 75 Genes involved in Citric acid cycle (TCA cycle) www.broad.mit.e...
Broad REACTOME_TELOMERE_MAINTENANCE View Gene Set 0.0004064 77 0.002299 76 Genes involved in Telomere Maintenance www.broad.mit.e...
Broad REACTOME_OLFACTORY_SIGNALING_PATHWAY View Gene Set 0.0004581 371 0.002558 77 Genes involved in Olfactory Signaling Pathway www.broad.mit.e...
Broad REACTOME_INFLUENZA_LIFE_CYCLE View Gene Set 0.0007047 137 0.003885 78 Genes involved in Influenza Life Cycle www.broad.mit.e...
Broad REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX View Gene Set 0.0007451 32 0.004056 79 Genes involved in Formation of the Early Elongation Complex www.broad.mit.e...
Broad REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION View Gene Set 0.0009441 10 0.005075 80 Genes involved in E2F-enabled inhibition of pre-replication complex formation www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING_MINOR_PATHWAY View Gene Set 0.0009958 38 0.005286 81 Genes involved in mRNA Splicing - Minor Pathway www.broad.mit.e...
Broad REACTOME_METABLISM_OF_NUCLEOTIDES View Gene Set 0.001081 71 0.005669 82 Genes involved in Metablism of nucleotides www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_ELONGATION View Gene Set 0.001235 41 0.006398 83 Genes involved in HIV-1 Transcription Elongation www.broad.mit.e...
Broad REACTOME_UNWINDING_OF_DNA View Gene Set 0.001378 11 0.007056 84 Genes involved in Unwinding of DNA www.broad.mit.e...
Broad REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC:ORIGIN_COMPLEX View Gene Set 0.001847 11 0.009343 85 Genes involved in CDC6 association with the ORC:origin complex www.broad.mit.e...
Broad REACTOME_CONVERSION_FROM_APC_CDC20_TO_APC_CDH1_IN_LATE_ANAPHASE View Gene Set 0.002086 17 0.01043 86 Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase www.broad.mit.e...
Broad REACTOME_MICRORNA_BIOGENESIS View Gene Set 0.002487 18 0.01229 87 Genes involved in MicroRNA biogenesis www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_CARBOHYDRATES View Gene Set 0.002565 119 0.01253 88 Genes involved in Metabolism of carbohydrates www.broad.mit.e...
Broad REACTOME_GLOBAL_GENOMIC_NER View Gene Set 0.002879 33 0.01391 89 Genes involved in Global Genomic NER (GG-NER) www.broad.mit.e...
Broad REACTOME_APOPTOSIS View Gene Set 0.00327 129 0.01545 90 Genes involved in Apoptosis www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PREREPLICATIVE_COMPLEX View Gene Set 0.003236 12 0.01545 90 Genes involved in Association of licensing factors with the pre-replicative complex www.broad.mit.e...
Broad REACTOME_MTORC1_MEDIATED_SIGNALLING View Gene Set 0.003433 11 0.01605 92 Genes involved in mTORC1-mediated signalling www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME View Gene Set 0.003674 59 0.01699 93 Genes involved in Transcription of the HIV genome www.broad.mit.e...
Broad REACTOME_REPAIR_SYNTHESIS_OF_PATCH_27_30_BASES_LONG_BY_DNA_POLYMERASE View Gene Set 0.003837 15 0.01755 94 Genes involved in Repair synthesis of patch ~27-30 bases long by DNA polymerase www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE View Gene Set 0.004124 13 0.01867 95 Genes involved in mRNA Decay by 5' to 3' Exoribonuclease www.broad.mit.e...
Broad REACTOME_FANCONI_ANEMIA_PATHWAY View Gene Set 0.004384 15 0.01944 96 Genes involved in Fanconi Anemia pathway www.broad.mit.e...
Broad REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES View Gene Set 0.004343 18 0.01944 96 Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates www.broad.mit.e...
Broad REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT View Gene Set 0.004735 23 0.02078 98 Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat www.broad.mit.e...
Broad REACTOME_TAT_MEDIATED_HIV1_ELONGATION_ARREST_AND_RECOVERY View Gene Set 0.005594 30 0.0243 99 Genes involved in Tat-mediated HIV-1 elongation arrest and recovery www.broad.mit.e...
Broad REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR View Gene Set 0.005694 15 0.02448 100 Genes involved in Homologous Recombination Repair www.broad.mit.e...
Broad REACTOME_TRANSLATION_INITIATION_COMPLEX_FORMATION View Gene Set 0.006336 56 0.02698 101 Genes involved in Translation initiation complex formation www.broad.mit.e...
Broad REACTOME_TRANSLATION View Gene Set 0.00644 120 0.02715 102 Genes involved in Translation www.broad.mit.e...
Broad REACTOME_DOUBLE_STRAND_BREAK_REPAIR View Gene Set 0.00743 21 0.03102 103 Genes involved in Double-Strand Break Repair www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_INITIATION View Gene Set 0.007589 39 0.03138 104 Genes involved in HIV-1 Transcription Initiation www.broad.mit.e...
Broad REACTOME_BASE_EXCISION_REPAIR View Gene Set 0.00832 18 0.03386 105 Genes involved in Base Excision Repair www.broad.mit.e...
Broad REACTOME_DUAL_INCISION_REACTION_IN_TC_NER View Gene Set 0.008346 28 0.03386 105 Genes involved in Dual incision reaction in TC-NER www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_AMINO_ACIDS View Gene Set 0.008934 162 0.0359 107 Genes involved in Metabolism of amino acids www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_III_AND_MITOCHONDRIAL_TRANSCRIPTION View Gene Set 0.01025 120 0.04079 108 Genes involved in RNA Polymerase I RNA Polymerase III and Mitochondrial Transcription www.broad.mit.e...
Broad REACTOME_LAGGING_STRAND_SYNTHESIS View Gene Set 0.0106 20 0.04181 109 Genes involved in Lagging Strand Synthesis www.broad.mit.e...
Broad REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS View Gene Set 0.01144 11 0.04471 110 Genes involved in Purine ribonucleoside monophosphate biosynthesis www.broad.mit.e...

Gene Set Collection: Broad.c3.TFT

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad V$E2F_Q4 View Gene Set 7.403e-07 166 0.0004553 1 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad SCGGAAGY_V$ELK1_02 View Gene Set 3.209e-06 784 0.0009869 2 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SCGGAAGY which matches annotation for ELK1: ELK1 member of ETS oncogene family www.broad.mit.e...
Broad V$E2F_Q6 View Gene Set 5.424e-06 165 0.001112 3 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q4_01 View Gene Set 1.092e-05 171 0.001678 4 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1DP1RB_01 View Gene Set 1.529e-05 168 0.00188 5 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad V$E2F_Q3_01 View Gene Set 3.553e-05 171 0.003642 6 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$MYCMAX_01 View Gene Set 4.629e-05 189 0.004067 7 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNACCACGTGGTNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad V$E2F1DP1_01 View Gene Set 8.117e-05 169 0.00416 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1DP2_01 View Gene Set 8.117e-05 169 0.00416 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F4DP2_01 View Gene Set 8.117e-05 169 0.00416 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F_Q6_01 View Gene Set 7.582e-05 167 0.00416 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKCGCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1_Q4_01 View Gene Set 7.543e-05 167 0.00416 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F_02 View Gene Set 9.035e-05 169 0.004274 13 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q3 View Gene Set 0.0001229 176 0.005025 14 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKTSSCGC which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$E2F4DP1_01 View Gene Set 0.0001307 174 0.005025 14 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad CACGTG_V$MYC_Q2 View Gene Set 0.0001192 734 0.005025 14 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CACGTG which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian) www.broad.mit.e...
Broad V$E2F1_Q6 View Gene Set 0.0001984 167 0.0068 17 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$E2F_03 View Gene Set 0.0001999 171 0.0068 17 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGCGMNR. Motif does not match any known transcription factor www.broad.mit.e...
Broad SGCGSSAAA_V$E2F1DP2_01 View Gene Set 0.0002101 122 0.0068 17 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SGCGSSAAA which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad V$E2F1_Q6_01 View Gene Set 0.0003281 177 0.01009 20 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTTTCGCGCS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad GCCATNTTG_V$YY1_Q6 View Gene Set 0.0003735 289 0.01094 21 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCATNTTG which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad GKCGCNNNNNNNTGAYG_UNKNOWN View Gene Set 0.001073 41 0.02999 22 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GKCGCNNNNNNNTGAYG. Motif does not match any known transcription factor www.broad.mit.e...
Broad RCGCANGCGY_V$NRF1_Q6 View Gene Set 0.00152 580 0.04064 23 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif RCGCANGCGY which matches annotation for NRF1: nuclear respiratory factor 1 www.broad.mit.e...
Broad V$USF_C View Gene Set 0.001612 211 0.04132 24 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NCACGTGN. Motif does not match any known transcription factor www.broad.mit.e...

Gene Set Collection: Broad.c4.CGN

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad GNF2_RRM1 View Gene Set 1.897e-29 82 8.098e-27 1 Neighborhood of RRM1 www.broad.mit.e...
Broad GNF2_CCNB2 View Gene Set 1.106e-28 53 2.362e-26 2 Neighborhood of CCNB2 www.broad.mit.e...
Broad GNF2_CDC20 View Gene Set 3.95e-28 52 5.622e-26 3 Neighborhood of CDC20 www.broad.mit.e...
Broad GNF2_CENPF View Gene Set 1.745e-27 56 1.863e-25 4 Neighborhood of CENPF www.broad.mit.e...
Broad GNF2_CCNA2 View Gene Set 3.882e-27 62 3.316e-25 5 Neighborhood of CCNA2 www.broad.mit.e...
Broad MORF_BUB3 View Gene Set 7.511e-26 256 5.346e-24 6 Neighborhood of BUB3 www.broad.mit.e...
Broad GNF2_PCNA View Gene Set 1.895e-25 62 1.012e-23 7 Neighborhood of PCNA www.broad.mit.e...
Broad GNF2_SMC4L1 View Gene Set 1.663e-25 75 1.012e-23 7 Neighborhood of SMC4L1 www.broad.mit.e...
Broad GNF2_CDC2 View Gene Set 6.563e-24 56 3.114e-22 9 Neighborhood of CDC2 www.broad.mit.e...
Broad GNF2_HMMR View Gene Set 2.892e-23 43 1.235e-21 10 Neighborhood of HMMR www.broad.mit.e...
Broad GNF2_MCM4 View Gene Set 1.114e-21 50 4.322e-20 11 Neighborhood of MCM4 www.broad.mit.e...
Broad GNF2_BUB1B View Gene Set 1.593e-20 46 5.67e-19 12 Neighborhood of BUB1B www.broad.mit.e...
Broad GNF2_RFC4 View Gene Set 1.738e-20 57 5.708e-19 13 Neighborhood of RFC4 www.broad.mit.e...
Broad GNF2_FEN1 View Gene Set 7.135e-20 49 2.176e-18 14 Neighborhood of FEN1 www.broad.mit.e...
Broad MORF_EIF3S2 View Gene Set 9.843e-20 220 2.802e-18 15 Neighborhood of EIF3S2 www.broad.mit.e...
Broad MORF_PRKDC View Gene Set 2.302e-19 173 6.143e-18 16 Neighborhood of PRKDC www.broad.mit.e...
Broad GNF2_CKS2 View Gene Set 3.054e-19 45 7.67e-18 17 Neighborhood of CKS2 www.broad.mit.e...
Broad GNF2_ESPL1 View Gene Set 3.794e-19 35 9.001e-18 18 Neighborhood of ESPL1 www.broad.mit.e...
Broad MORF_RAD23A View Gene Set 6.039e-19 316 1.357e-17 19 Neighborhood of RAD23A www.broad.mit.e...
Broad GNF2_CENPE View Gene Set 9.072e-19 37 1.937e-17 20 Neighborhood of CENPE www.broad.mit.e...
Broad GNF2_TTK View Gene Set 7.142e-18 34 1.452e-16 21 Neighborhood of TTK www.broad.mit.e...
Broad GNF2_RRM2 View Gene Set 8.404e-18 36 1.631e-16 22 Neighborhood of RRM2 www.broad.mit.e...
Broad GNF2_PA2G4 View Gene Set 3.279e-17 73 6.088e-16 23 Neighborhood of PA2G4 www.broad.mit.e...
Broad GNF2_RFC3 View Gene Set 1.724e-16 38 3.068e-15 24 Neighborhood of RFC3 www.broad.mit.e...
Broad GNF2_CKS1B View Gene Set 2.805e-16 36 4.791e-15 25 Neighborhood of CKS1B www.broad.mit.e...
Broad MORF_RFC4 View Gene Set 6.018e-16 137 9.884e-15 26 Neighborhood of RFC4 www.broad.mit.e...
Broad GNF2_MKI67 View Gene Set 2.649e-15 26 4.189e-14 27 Neighborhood of MKI67 www.broad.mit.e...
Broad MORF_HDAC2 View Gene Set 3.178e-15 256 4.68e-14 28 Neighborhood of HDAC2 www.broad.mit.e...
Broad MORF_AATF View Gene Set 3.122e-15 179 4.68e-14 28 Neighborhood of AATF www.broad.mit.e...
Broad GNF2_BUB1 View Gene Set 3.36e-15 25 4.783e-14 30 Neighborhood of BUB1 www.broad.mit.e...
Broad MORF_UBE2I View Gene Set 5.765e-15 208 7.941e-14 31 Neighborhood of UBE2I www.broad.mit.e...
Broad GNF2_RAN View Gene Set 1.126e-14 78 1.502e-13 32 Neighborhood of RAN www.broad.mit.e...
Broad GNF2_H2AFX View Gene Set 1.412e-14 28 1.827e-13 33 Neighborhood of H2AFX www.broad.mit.e...
Broad MORF_FBL View Gene Set 1.635e-14 121 2.054e-13 34 Neighborhood of FBL www.broad.mit.e...
Broad GNF2_SMC2L1 View Gene Set 2.975e-14 30 3.63e-13 35 Neighborhood of SMC2L1 www.broad.mit.e...
Broad MORF_ANP32B View Gene Set 4.869e-14 174 5.775e-13 36 Neighborhood of ANP32B www.broad.mit.e...
Broad MORF_DNMT1 View Gene Set 5.869e-14 105 6.773e-13 37 Neighborhood of DNMT1 www.broad.mit.e...
Broad MORF_CSNK2B View Gene Set 3.966e-13 256 4.342e-12 38 Neighborhood of CSNK2B www.broad.mit.e...
Broad GNF2_MCM5 View Gene Set 3.896e-13 51 4.342e-12 38 Neighborhood of MCM5 www.broad.mit.e...
Broad MORF_UNG View Gene Set 5.099e-13 65 5.444e-12 40 Neighborhood of UNG www.broad.mit.e...
Broad MORF_HAT1 View Gene Set 5.563e-13 155 5.794e-12 41 Neighborhood of HAT1 www.broad.mit.e...
Broad MORF_ACP1 View Gene Set 1.275e-12 178 1.296e-11 42 Neighborhood of ACP1 www.broad.mit.e...
Broad MORF_RAD54L View Gene Set 4.117e-12 94 4.089e-11 43 Neighborhood of RAD54L www.broad.mit.e...
Broad MORF_PPP1CC View Gene Set 6.655e-12 150 6.458e-11 44 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_BUB1 View Gene Set 9.861e-12 49 9.357e-11 45 Neighborhood of BUB1 www.broad.mit.e...
Broad MORF_SOD1 View Gene Set 2.352e-11 247 2.137e-10 46 Neighborhood of SOD1 www.broad.mit.e...
Broad GNF2_APEX1 View Gene Set 2.309e-11 72 2.137e-10 46 Neighborhood of APEX1 www.broad.mit.e...
Broad MORF_PCNA View Gene Set 3.589e-11 71 3.193e-10 48 Neighborhood of PCNA www.broad.mit.e...
Broad MORF_RRM1 View Gene Set 3.936e-11 90 3.43e-10 49 Neighborhood of RRM1 www.broad.mit.e...
Broad MORF_ESPL1 View Gene Set 5.142e-11 58 4.391e-10 50 Neighborhood of ESPL1 www.broad.mit.e...
Broad GNF2_DEK View Gene Set 1.069e-10 45 8.946e-10 51 Neighborhood of DEK www.broad.mit.e...
Broad MORF_FEN1 View Gene Set 1.805e-10 58 1.483e-09 52 Neighborhood of FEN1 www.broad.mit.e...
Broad MORF_RPA2 View Gene Set 5.023e-10 170 4.046e-09 53 Neighborhood of RPA2 www.broad.mit.e...
Broad MORF_RAN View Gene Set 5.857e-10 242 4.632e-09 54 Neighborhood of RAN www.broad.mit.e...
Broad MORF_MSH2 View Gene Set 6.92e-10 52 5.372e-09 55 Neighborhood of MSH2 www.broad.mit.e...
Broad GCM_APEX1 View Gene Set 1.134e-09 102 8.649e-09 56 Neighborhood of APEX1 www.broad.mit.e...
Broad MORF_XRCC5 View Gene Set 1.208e-09 210 9.053e-09 57 Neighborhood of XRCC5 www.broad.mit.e...
Broad MORF_BUB1B View Gene Set 3.995e-09 61 2.941e-08 58 Neighborhood of BUB1B www.broad.mit.e...
Broad MORF_DDB1 View Gene Set 6.363e-09 220 4.528e-08 59 Neighborhood of DDB1 www.broad.mit.e...
Broad MORF_EI24 View Gene Set 6.295e-09 136 4.528e-08 59 Neighborhood of EI24 www.broad.mit.e...
Broad MORF_G22P1 View Gene Set 7.025e-09 145 4.917e-08 61 Neighborhood of G22P1 www.broad.mit.e...
Broad GNF2_HAT1 View Gene Set 8.576e-09 45 5.906e-08 62 Neighborhood of HAT1 www.broad.mit.e...
Broad MORF_RAD21 View Gene Set 1.427e-08 157 9.675e-08 63 Neighborhood of RAD21 www.broad.mit.e...
Broad MORF_PHB View Gene Set 2.416e-08 112 1.612e-07 64 Neighborhood of PHB www.broad.mit.e...
Broad MORF_DEK View Gene Set 5.119e-08 229 3.363e-07 65 Neighborhood of DEK www.broad.mit.e...
Broad GNF2_XRCC5 View Gene Set 7e-08 61 4.528e-07 66 Neighborhood of XRCC5 www.broad.mit.e...
Broad GCM_ACTG1 View Gene Set 7.505e-08 113 4.783e-07 67 Neighborhood of ACTG1 www.broad.mit.e...
Broad MORF_GNB1 View Gene Set 9.374e-08 276 5.886e-07 68 Neighborhood of GNB1 www.broad.mit.e...
Broad MORF_RPA1 View Gene Set 1.276e-07 55 7.897e-07 69 Neighborhood of RPA1 www.broad.mit.e...
Broad MORF_PTPN11 View Gene Set 2.08e-07 93 1.269e-06 70 Neighborhood of PTPN11 www.broad.mit.e...
Broad GNF2_KPNB1 View Gene Set 2.448e-07 52 1.472e-06 71 Neighborhood of KPNB1 www.broad.mit.e...
Broad GNF2_NPM1 View Gene Set 3.343e-07 57 1.982e-06 72 Neighborhood of NPM1 www.broad.mit.e...
Broad GNF2_MSH6 View Gene Set 4.182e-07 30 2.446e-06 73 Neighborhood of MSH6 www.broad.mit.e...
Broad MORF_CDK2 View Gene Set 4.331e-07 63 2.499e-06 74 Neighborhood of CDK2 www.broad.mit.e...
Broad GNF2_ANP32B View Gene Set 6.46e-07 29 3.678e-06 75 Neighborhood of ANP32B www.broad.mit.e...
Broad GCM_CBFB View Gene Set 8.32e-07 59 4.675e-06 76 Neighborhood of CBFB www.broad.mit.e...
Broad MORF_MAP2K2 View Gene Set 9.658e-07 123 5.356e-06 77 Neighborhood of MAP2K2 www.broad.mit.e...
Broad GNF2_NS View Gene Set 1.327e-06 35 7.266e-06 78 Neighborhood of NS www.broad.mit.e...
Broad GCM_PPP1CC View Gene Set 1.779e-06 47 9.616e-06 79 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_GSPT1 View Gene Set 2.173e-06 41 1.16e-05 80 Neighborhood of GSPT1 www.broad.mit.e...
Broad MORF_SMC1L1 View Gene Set 2.246e-06 47 1.184e-05 81 Neighborhood of SMC1L1 www.broad.mit.e...
Broad GNF2_MLH1 View Gene Set 2.29e-06 36 1.192e-05 82 Neighborhood of MLH1 www.broad.mit.e...
Broad MORF_HDAC1 View Gene Set 2.322e-06 222 1.195e-05 83 Neighborhood of HDAC1 www.broad.mit.e...
Broad MORF_SNRP70 View Gene Set 2.358e-06 50 1.199e-05 84 Neighborhood of SNRP70 www.broad.mit.e...
Broad MORF_UBE2N View Gene Set 2.828e-06 79 1.42e-05 85 Neighborhood of UBE2N www.broad.mit.e...
Broad MORF_PRKAG1 View Gene Set 3.068e-06 202 1.523e-05 86 Neighborhood of PRKAG1 www.broad.mit.e...
Broad MORF_SART1 View Gene Set 5.218e-06 55 2.561e-05 87 Neighborhood of SART1 www.broad.mit.e...
Broad MORF_GMPS View Gene Set 5.428e-06 48 2.634e-05 88 Neighborhood of GMPS www.broad.mit.e...
Broad GNF2_RBBP6 View Gene Set 5.563e-06 54 2.669e-05 89 Neighborhood of RBBP6 www.broad.mit.e...
Broad MORF_NPM1 View Gene Set 5.753e-06 152 2.699e-05 90 Neighborhood of NPM1 www.broad.mit.e...
Broad GNF2_RPA1 View Gene Set 5.733e-06 20 2.699e-05 90 Neighborhood of RPA1 www.broad.mit.e...
Broad GCM_CSNK2B View Gene Set 6.05e-06 88 2.808e-05 92 Neighborhood of CSNK2B www.broad.mit.e...
Broad MORF_EIF3S6 View Gene Set 6.988e-06 108 3.208e-05 93 Neighborhood of EIF3S6 www.broad.mit.e...
Broad GNF2_FBL View Gene Set 8.232e-06 119 3.74e-05 94 Neighborhood of FBL www.broad.mit.e...
Broad GNF2_MSH2 View Gene Set 8.792e-06 26 3.911e-05 95 Neighborhood of MSH2 www.broad.mit.e...
Broad GNF2_G22P1 View Gene Set 8.748e-06 29 3.911e-05 95 Neighborhood of G22P1 www.broad.mit.e...
Broad MORF_DEAF1 View Gene Set 9.714e-06 54 4.276e-05 97 Neighborhood of DEAF1 www.broad.mit.e...
Broad MORF_USP5 View Gene Set 1.177e-05 46 5.127e-05 98 Neighborhood of USP5 www.broad.mit.e...
Broad MORF_DAP3 View Gene Set 1.366e-05 175 5.893e-05 99 Neighborhood of DAP3 www.broad.mit.e...
Broad MORF_PSMC1 View Gene Set 1.473e-05 162 6.291e-05 100 Neighborhood of PSMC1 www.broad.mit.e...
Broad GNF2_SMC1L1 View Gene Set 1.564e-05 24 6.61e-05 101 Neighborhood of SMC1L1 www.broad.mit.e...
Broad MORF_PPP1CA View Gene Set 1.987e-05 145 8.318e-05 102 Neighborhood of PPP1CA www.broad.mit.e...
Broad MORF_MTA1 View Gene Set 4.993e-05 95 0.000207 103 Neighborhood of MTA1 www.broad.mit.e...
Broad GNF2_BUB3 View Gene Set 5.17e-05 22 0.0002123 104 Neighborhood of BUB3 www.broad.mit.e...
Broad MORF_CCNI View Gene Set 5.475e-05 76 0.0002227 105 Neighborhood of CCNI www.broad.mit.e...
Broad MORF_EIF4A2 View Gene Set 6.12e-05 120 0.0002465 106 Neighborhood of EIF4A2 www.broad.mit.e...
Broad MORF_CCNF View Gene Set 7.988e-05 65 0.0003188 107 Neighborhood of CCNF www.broad.mit.e...
Broad MORF_NME2 View Gene Set 0.0001125 145 0.0004449 108 Neighborhood of NME2 www.broad.mit.e...
Broad GCM_DDX5 View Gene Set 0.0001422 52 0.000557 109 Neighborhood of DDX5 www.broad.mit.e...
Broad MORF_CDC16 View Gene Set 0.0001939 67 0.0007528 110 Neighborhood of CDC16 www.broad.mit.e...
Broad GNF2_ST13 View Gene Set 0.0002061 56 0.0007928 111 Neighborhood of ST13 www.broad.mit.e...
Broad MORF_CDC10 View Gene Set 0.0003875 120 0.001477 112 Neighborhood of CDC10 www.broad.mit.e...
Broad MORF_CUL1 View Gene Set 0.0004019 62 0.001519 113 Neighborhood of CUL1 www.broad.mit.e...
Broad GNF2_HDAC1 View Gene Set 0.0004898 85 0.001835 114 Neighborhood of HDAC1 www.broad.mit.e...
Broad GNF2_ELAC2 View Gene Set 0.0005077 32 0.001885 115 Neighborhood of ELAC2 www.broad.mit.e...
Broad GCM_PSME1 View Gene Set 0.0005268 76 0.001939 116 Neighborhood of PSME1 www.broad.mit.e...
Broad MORF_ERH View Gene Set 0.0005371 103 0.001944 117 Neighborhood of ERH www.broad.mit.e...
Broad MORF_SKP1A View Gene Set 0.0005358 175 0.001944 117 Neighborhood of SKP1A www.broad.mit.e...
Broad MORF_CTBP1 View Gene Set 0.0005627 149 0.002019 119 Neighborhood of CTBP1 www.broad.mit.e...
Broad GNF2_DAP3 View Gene Set 0.0005813 98 0.002068 120 Neighborhood of DAP3 www.broad.mit.e...
Broad GCM_NF2 View Gene Set 0.0008656 235 0.003055 121 Neighborhood of NF2 www.broad.mit.e...
Broad GNF2_DENR View Gene Set 0.001436 39 0.005026 122 Neighborhood of DENR www.broad.mit.e...
Broad MORF_TERF1 View Gene Set 0.001471 57 0.005107 123 Neighborhood of TERF1 www.broad.mit.e...
Broad GNF2_UBE2I View Gene Set 0.001692 33 0.005826 124 Neighborhood of UBE2I www.broad.mit.e...
Broad MORF_RAB11A View Gene Set 0.001891 53 0.006458 125 Neighborhood of RAB11A www.broad.mit.e...
Broad MORF_TERF2IP View Gene Set 0.00213 99 0.007219 126 Neighborhood of TERF2IP www.broad.mit.e...
Broad MORF_BMI1 View Gene Set 0.002186 71 0.007349 127 Neighborhood of BMI1 www.broad.mit.e...
Broad GCM_RAD21 View Gene Set 0.002356 30 0.00786 128 Neighborhood of RAD21 www.broad.mit.e...
Broad MORF_AP2M1 View Gene Set 0.002796 197 0.009254 129 Neighborhood of AP2M1 www.broad.mit.e...
Broad GCM_VAV1 View Gene Set 0.003151 46 0.01035 130 Neighborhood of VAV1 www.broad.mit.e...
Broad MORF_FANCG View Gene Set 0.003256 148 0.01061 131 Neighborhood of FANCG www.broad.mit.e...
Broad GNF2_EIF3S6 View Gene Set 0.00328 109 0.01061 131 Neighborhood of EIF3S6 www.broad.mit.e...
Broad GCM_NPM1 View Gene Set 0.003546 108 0.01139 133 Neighborhood of NPM1 www.broad.mit.e...
Broad GNF2_TDG View Gene Set 0.003675 23 0.01171 134 Neighborhood of TDG www.broad.mit.e...
Broad MORF_EIF4E View Gene Set 0.003781 76 0.01196 135 Neighborhood of EIF4E www.broad.mit.e...
Broad MORF_PPP2R5E View Gene Set 0.004902 76 0.01539 136 Neighborhood of PPP2R5E www.broad.mit.e...
Broad GCM_RBM8A View Gene Set 0.005476 64 0.01707 137 Neighborhood of RBM8A www.broad.mit.e...
Broad MORF_RAF1 View Gene Set 0.005664 94 0.01752 138 Neighborhood of RAF1 www.broad.mit.e...
Broad GCM_SMARCC1 View Gene Set 0.006032 33 0.01853 139 Neighborhood of SMARCC1 www.broad.mit.e...
Broad MORF_RAD23B View Gene Set 0.00724 159 0.02208 140 Neighborhood of RAD23B www.broad.mit.e...
Broad GCM_DFFA View Gene Set 0.00749 100 0.02268 141 Neighborhood of DFFA www.broad.mit.e...
Broad MORF_IKBKG View Gene Set 0.007634 119 0.02296 142 Neighborhood of IKBKG www.broad.mit.e...
Broad MORF_ACTG1 View Gene Set 0.008839 134 0.02639 143 Neighborhood of ACTG1 www.broad.mit.e...
Broad GCM_DENR View Gene Set 0.01169 40 0.03467 144 Neighborhood of DENR www.broad.mit.e...
Broad GCM_BECN1 View Gene Set 0.01253 59 0.03689 145 Neighborhood of BECN1 www.broad.mit.e...
Broad MORF_PPP2CA View Gene Set 0.01579 110 0.04618 146 Neighborhood of PPP2CA www.broad.mit.e...
Broad GCM_ING1 View Gene Set 0.0165 50 0.04794 147 Neighborhood of ING1 www.broad.mit.e...
Broad MORF_RFC1 View Gene Set 0.01668 98 0.04812 148 Neighborhood of RFC1 www.broad.mit.e...

Gene Set Collection: Broad.c4.CM

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad module_54 View Gene Set 2.97e-34 242 1.348e-31 1 Genes in module_54 www.broad.mit.e...
Broad module_198 View Gene Set 2.03e-17 288 3.072e-15 2 Genes in module_198 www.broad.mit.e...
Broad module_252 View Gene Set 1.486e-17 224 3.072e-15 2 Genes in module_252 www.broad.mit.e...
Broad module_98 View Gene Set 1.839e-16 375 2.088e-14 4 Genes in module_98 www.broad.mit.e...
Broad module_17 View Gene Set 2.046e-14 351 1.858e-12 5 Genes in module_17 www.broad.mit.e...
Broad module_244 View Gene Set 1.948e-12 182 1.474e-10 6 Genes in module_244 www.broad.mit.e...
Broad module_403 View Gene Set 7.66e-12 44 4.968e-10 7 Genes in module_403 www.broad.mit.e...
Broad module_124 View Gene Set 3.7e-09 92 2.1e-07 8 Genes in module_124 www.broad.mit.e...
Broad module_315 View Gene Set 4.585e-09 15 2.313e-07 9 Genes in module_315 www.broad.mit.e...
Broad module_126 View Gene Set 1.539e-08 173 6.988e-07 10 Genes in module_126 www.broad.mit.e...
Broad module_158 View Gene Set 5.627e-08 41 2.322e-06 11 Genes in module_158 www.broad.mit.e...
Broad module_125 View Gene Set 1.166e-07 42 4.412e-06 12 Genes in module_125 www.broad.mit.e...
Broad module_32 View Gene Set 4.23e-07 227 1.477e-05 13 Genes in module_32 www.broad.mit.e...
Broad module_320 View Gene Set 4.719e-07 19 1.53e-05 14 Genes in module_320 www.broad.mit.e...
Broad module_57 View Gene Set 5.546e-07 54 1.679e-05 15 Genes in module_57 www.broad.mit.e...
Broad module_183 View Gene Set 6.079e-07 52 1.725e-05 16 Genes in module_183 www.broad.mit.e...
Broad module_28 View Gene Set 7.073e-07 32 1.784e-05 17 Genes in module_28 www.broad.mit.e...
Broad module_337 View Gene Set 6.806e-07 59 1.784e-05 17 Genes in module_337 www.broad.mit.e...
Broad module_392 View Gene Set 9.646e-07 18 2.305e-05 19 Genes in module_392 www.broad.mit.e...
Broad module_451 View Gene Set 1.028e-06 29 2.334e-05 20 Genes in module_451 www.broad.mit.e...
Broad module_91 View Gene Set 2.428e-06 37 5.248e-05 21 Genes in module_91 www.broad.mit.e...
Broad module_397 View Gene Set 6.037e-06 114 0.0001246 22 Genes in module_397 www.broad.mit.e...
Broad module_219 View Gene Set 1.025e-05 26 0.0002022 23 Genes in module_219 www.broad.mit.e...
Broad module_3 View Gene Set 2.105e-05 374 0.0003981 24 Genes in module_3 www.broad.mit.e...
Broad module_197 View Gene Set 3.309e-05 170 0.0006009 25 Genes in module_197 www.broad.mit.e...
Broad module_299 View Gene Set 0.0001033 33 0.001804 26 Genes in module_299 www.broad.mit.e...
Broad module_352 View Gene Set 0.0001575 17 0.002648 27 Genes in module_352 www.broad.mit.e...
Broad module_355 View Gene Set 0.0001735 28 0.002814 28 Genes in module_355 www.broad.mit.e...
Broad module_253 View Gene Set 0.0002629 21 0.003978 29 Genes in module_253 www.broad.mit.e...
Broad module_457 View Gene Set 0.0002616 9 0.003978 29 Genes in module_457 www.broad.mit.e...
Broad module_168 View Gene Set 0.0004749 22 0.006738 31 Genes in module_168 www.broad.mit.e...
Broad module_421 View Gene Set 0.0004722 23 0.006738 31 Genes in module_421 www.broad.mit.e...
Broad module_203 View Gene Set 0.0005348 16 0.007227 33 Genes in module_203 www.broad.mit.e...
Broad module_278 View Gene Set 0.0005412 34 0.007227 33 Genes in module_278 www.broad.mit.e...
Broad module_388 View Gene Set 0.0006324 17 0.008203 35 Genes in module_388 www.broad.mit.e...
Broad module_90 View Gene Set 0.0006717 17 0.008471 36 Genes in module_90 www.broad.mit.e...
Broad module_196 View Gene Set 0.0007238 23 0.008882 37 Genes in module_196 www.broad.mit.e...
Broad module_127 View Gene Set 0.001117 26 0.01334 38 Genes in module_127 www.broad.mit.e...
Broad module_155 View Gene Set 0.001221 25 0.01421 39 Genes in module_155 www.broad.mit.e...
Broad module_189 View Gene Set 0.001252 23 0.01421 39 Genes in module_189 www.broad.mit.e...
Broad module_61 View Gene Set 0.001313 50 0.01453 41 Genes in module_61 www.broad.mit.e...
Broad module_222 View Gene Set 0.001452 22 0.0157 42 Genes in module_222 www.broad.mit.e...
Broad module_50 View Gene Set 0.002716 13 0.02802 43 Genes in module_50 www.broad.mit.e...
Broad module_72 View Gene Set 0.002672 293 0.02802 43 Genes in module_72 www.broad.mit.e...
Broad module_89 View Gene Set 0.003009 14 0.03036 45 Genes in module_89 www.broad.mit.e...
Broad module_552 View Gene Set 0.003331 18 0.03287 46 Genes in module_552 www.broad.mit.e...
Broad module_16 View Gene Set 0.003714 495 0.03587 47 Genes in module_16 www.broad.mit.e...
Broad module_245 View Gene Set 0.004167 26 0.03942 48 Genes in module_245 www.broad.mit.e...
Broad module_485 View Gene Set 0.004582 44 0.04246 49 Genes in module_485 www.broad.mit.e...
Broad module_273 View Gene Set 0.004738 50 0.04302 50 Genes in module_273 www.broad.mit.e...
Broad module_105 View Gene Set 0.005331 192 0.04746 51 Genes in module_105 www.broad.mit.e...

Gene Set Collection: Broad.c5.BP

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad CELL_CYCLE_PROCESS View Gene Set 7.622e-14 187 6.289e-11 1 Genes annotated by the GO term GO:0022402. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad M_PHASE_OF_MITOTIC_CELL_CYCLE View Gene Set 1.026e-12 83 4.23e-10 2 Genes annotated by the GO term GO:0000087. Progression through M phase the part of the mitotic cell cycle during which mitosis takes place. www.broad.mit.e...
Broad M_PHASE View Gene Set 3.47e-12 111 7.157e-10 3 Genes annotated by the GO term GO:0000279. Progression through M phase the part of the cell cycle comprising nuclear division. www.broad.mit.e...
Broad MITOSIS View Gene Set 2.751e-12 81 7.157e-10 3 Genes annotated by the GO term GO:0007067. Progression through mitosis the division of the eukaryotic cell nucleus to produce two daughter nuclei that usually contain the identical chromosome complement to their mother. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 1.76e-11 1197 2.904e-09 5 Genes annotated by the GO term GO:0006139. The chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad RNA_PROCESSING View Gene Set 3.16e-11 147 4.345e-09 6 Genes annotated by the GO term GO:0006396. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. www.broad.mit.e...
Broad MITOTIC_CELL_CYCLE View Gene Set 1.018e-10 148 1.2e-08 7 Genes annotated by the GO term GO:0000278. Progression through the phases of the mitotic cell cycle the most common eukaryotic cell cycle which canonically comprises four successive phases called G1 S G2 and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division or G1 and G2 phases may be absent. www.broad.mit.e...
Broad CELL_CYCLE_PHASE View Gene Set 7.584e-10 167 7.821e-08 8 Genes annotated by the GO term GO:0022403. A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad CELL_CYCLE_GO_0007049 View Gene Set 3.917e-09 304 3.591e-07 9 Genes annotated by the GO term GO:0007049. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. www.broad.mit.e...
Broad DNA_METABOLIC_PROCESS View Gene Set 1.496e-07 253 1.234e-05 10 Genes annotated by the GO term GO:0006259. The chemical reactions and pathways involving DNA deoxyribonucleic acid one of the two main types of nucleic acid consisting of a long unbranched macromolecule formed from one or more commonly two strands of linked deoxyribonucleotides. www.broad.mit.e...
Broad DNA_REPAIR View Gene Set 3.548e-07 123 2.661e-05 11 Genes annotated by the GO term GO:0006281. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations chemical mutagens fungal and bacterial toxins etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal base excision repair nucleotide excision repair photoreactivation bypass double-strand break repair pathway and mismatch repair pathway. www.broad.mit.e...
Broad RNA_METABOLIC_PROCESS View Gene Set 2.323e-06 801 0.0001505 12 Genes annotated by the GO term GO:0016070. The chemical reactions and pathways involving RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS_AND_ASSEMBLY View Gene Set 2.447e-06 74 0.0001505 12 Genes annotated by the GO term GO:0022613. The cellular process by which a complex containing RNA and proteins is synthesized aggregates and bonds together. www.broad.mit.e...
Broad RNA_SPLICING View Gene Set 2.553e-06 73 0.0001505 12 Genes annotated by the GO term GO:0008380. The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. www.broad.mit.e...
Broad CELL_CYCLE_CHECKPOINT_GO_0000075 View Gene Set 8.151e-06 47 0.0004203 15 Genes annotated by the GO term GO:0000075. A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. www.broad.mit.e...
Broad MRNA_PROCESSING_GO_0006397 View Gene Set 7.887e-06 59 0.0004203 15 Genes annotated by the GO term GO:0006397. Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. www.broad.mit.e...
Broad RESPONSE_TO_ENDOGENOUS_STIMULUS View Gene Set 9.976e-06 197 0.0004841 17 Genes annotated by the GO term GO:0009719. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of an endogenous stimulus. www.broad.mit.e...
Broad BIOPOLYMER_METABOLIC_PROCESS View Gene Set 1.258e-05 1623 0.0005768 18 Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers long repeating chains of monomers found in nature e.g. polysaccharides and proteins. www.broad.mit.e...
Broad RESPONSE_TO_DNA_DAMAGE_STIMULUS View Gene Set 1.679e-05 159 0.0007289 19 Genes annotated by the GO term GO:0006974. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. www.broad.mit.e...
Broad SPINDLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 1.949e-05 10 0.0008042 20 Genes annotated by the GO term GO:0007051. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of the spindle the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. www.broad.mit.e...
Broad RRNA_METABOLIC_PROCESS View Gene Set 2.562e-05 12 0.001006 21 Genes annotated by the GO term GO:0016072. The chemical reactions and pathways involving rRNA ribosomal RNA a structural constituent of ribosomes. www.broad.mit.e...
Broad RIBOSOME_BIOGENESIS_AND_ASSEMBLY View Gene Set 2.817e-05 14 0.001056 22 Genes annotated by the GO term GO:0042254. The process of the formation of the constituents of the ribosome subunits their assembly and their transport to the sites of protein synthesis. www.broad.mit.e...
Broad RRNA_PROCESSING View Gene Set 3.246e-05 11 0.001164 23 Genes annotated by the GO term GO:0006364. Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. www.broad.mit.e...
Broad REGULATION_OF_MITOSIS View Gene Set 3.887e-05 40 0.001336 24 Genes annotated by the GO term GO:0007088. Any process that modulates the frequency rate or extent of mitosis. www.broad.mit.e...
Broad MICROTUBULE_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS View Gene Set 4.106e-05 34 0.001355 25 Genes annotated by the GO term GO:0000226. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. www.broad.mit.e...
Broad MITOTIC_SPINDLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 4.833e-05 9 0.001534 26 Genes annotated by the GO term GO:0007052. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of the microtubule spindle during a mitotic cell cycle. www.broad.mit.e...
Broad MRNA_METABOLIC_PROCESS View Gene Set 8.059e-05 70 0.002463 27 Genes annotated by the GO term GO:0016071. The chemical reactions and pathways involving mRNA messenger RNA which is responsible for carrying the coded genetic 'message' transcribed from DNA to sites of protein assembly at the ribosomes. www.broad.mit.e...
Broad CHROMOSOME_ORGANIZATION_AND_BIOGENESIS View Gene Set 8.7e-05 117 0.002563 28 Genes annotated by the GO term GO:0051276. A process that is carried out at the cellular level that results in the formation arrangement of constituent parts or disassembly of chromosomes structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. www.broad.mit.e...
Broad TRANSLATION View Gene Set 0.0001255 177 0.003569 29 Genes annotated by the GO term GO:0006412. The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. www.broad.mit.e...
Broad MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.0001734 16 0.004714 30 Genes annotated by the GO term GO:0031023. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of a microtubule organizing center a structure from which microtubules grow. www.broad.mit.e...
Broad SISTER_CHROMATID_SEGREGATION View Gene Set 0.0001829 17 0.004714 30 Genes annotated by the GO term GO:0000819. The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad BASE_EXCISION_REPAIR View Gene Set 0.0001809 16 0.004714 30 Genes annotated by the GO term GO:0006284. In base excision repair an altered base is removed by a DNA glycosylase enzyme followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. www.broad.mit.e...
Broad PROTEIN_RNA_COMPLEX_ASSEMBLY View Gene Set 0.0001904 59 0.00476 33 Genes annotated by the GO term GO:0022618. The aggregation arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. www.broad.mit.e...
Broad MITOTIC_SISTER_CHROMATID_SEGREGATION View Gene Set 0.0002724 16 0.00661 34 Genes annotated by the GO term GO:0000070. The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome composed of two sister chromatids aligns at the cell equator paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. www.broad.mit.e...
Broad ORGANELLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.0002846 458 0.006709 35 Genes annotated by the GO term GO:0006996. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of any organelle within a cell. www.broad.mit.e...
Broad CHROMOSOME_SEGREGATION View Gene Set 0.000412 31 0.009442 36 Genes annotated by the GO term GO:0007059. The process by which genetic material in the form of chromosomes is organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad CENTROSOME_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.0005898 15 0.01315 37 Genes annotated by the GO term GO:0051297. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of a centrosome a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. www.broad.mit.e...
Broad MITOTIC_CELL_CYCLE_CHECKPOINT View Gene Set 0.0006425 21 0.01395 38 Genes annotated by the GO term GO:0007093. A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. www.broad.mit.e...
Broad PROTEIN_FOLDING View Gene Set 0.0007653 56 0.01619 39 Genes annotated by the GO term GO:0006457. The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. www.broad.mit.e...
Broad CELLULAR_BIOSYNTHETIC_PROCESS View Gene Set 0.0009314 311 0.01874 40 Genes annotated by the GO term GO:0044249. The chemical reactions and pathways resulting in the formation of substances carried out by individual cells. www.broad.mit.e...
Broad MITOCHONDRIAL_TRANSPORT View Gene Set 0.0009284 20 0.01874 40 Genes annotated by the GO term GO:0006839. Transport of substances into out of or within a mitochondrion. www.broad.mit.e...
Broad RNA_SPLICINGVIA_TRANSESTERIFICATION_REACTIONS View Gene Set 0.0009614 27 0.01888 42 Genes annotated by the GO term GO:0000375. Splicing of RNA via a series of two transesterification reactions. www.broad.mit.e...
Broad CHROMOSOME_CONDENSATION View Gene Set 0.001044 10 0.02004 43 Genes annotated by the GO term GO:0030261. The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division or during apoptosis in eukaryotic cells. www.broad.mit.e...
Broad CENTROSOME_CYCLE View Gene Set 0.001079 11 0.02023 44 Genes annotated by the GO term GO:0007098. The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. www.broad.mit.e...
Broad MITOCHONDRION_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.001748 47 0.03204 45 Genes annotated by the GO term GO:0007005. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of a mitochondrion; includes mitochondrial morphology and distribution and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. www.broad.mit.e...
Broad AMINO_ACID_METABOLIC_PROCESS View Gene Set 0.002446 75 0.04387 46 Genes annotated by the GO term GO:0006520. The chemical reactions and pathways involving amino acids organic acids containing one or more amino substituents. www.broad.mit.e...
Broad TRANSLATIONAL_INITIATION View Gene Set 0.002696 39 0.04732 47 Genes annotated by the GO term GO:0006413. The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome mRNA and an initiation complex that contains the first aminoacyl-tRNA. www.broad.mit.e...

Gene Set Collection: Broad.c5.CC

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad NUCLEAR_PART View Gene Set 7.287e-22 543 1.698e-19 1 Genes annotated by the GO term GO:0044428. Any constituent part of the nucleus a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. www.broad.mit.e...
Broad NUCLEUS View Gene Set 4.226e-20 1353 4.923e-18 2 Genes annotated by the GO term GO:0005634. A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells the nucleus contains all of the cell's chromosomes except the organellar chromosomes and is the site of RNA synthesis and processing. In some species or in specialized cell types RNA metabolism or DNA replication may be absent. www.broad.mit.e...
Broad INTRACELLULAR_ORGANELLE_PART View Gene Set 2.753e-15 1144 2.138e-13 3 Genes annotated by the GO term GO:0044446. A constituent part of an intracellular organelle an organized structure of distinctive morphology and function occurring within the cell. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad ORGANELLE_PART View Gene Set 5.628e-15 1149 3.278e-13 4 Genes annotated by the GO term GO:0044422. Any constituent part of an organelle an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad ORGANELLE_LUMEN View Gene Set 1.669e-14 434 6.481e-13 5 Genes annotated by the GO term GO:0043233. The volume enclosed by the membranes of a particular organelle e.g. endoplasmic reticulum lumen or the space between the two lipid bilayers of a double membrane surrounding an organelle e.g. nuclear membrane lumen. www.broad.mit.e...
Broad MEMBRANE_ENCLOSED_LUMEN View Gene Set 1.669e-14 434 6.481e-13 5 Genes annotated by the GO term GO:0031974. The enclosed volume within a sealed membrane or between two sealed membranes. www.broad.mit.e...
Broad NUCLEAR_LUMEN View Gene Set 3.325e-13 365 1.107e-11 7 Genes annotated by the GO term GO:0031981. The volume enclosed by the nuclear inner membrane. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX View Gene Set 6.923e-11 914 2.016e-09 8 Genes annotated by the GO term GO:0032991. A stable assembly of two or more macromolecules i.e. proteins nucleic acids carbohydrates or lipids in which the constituent parts function together. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX View Gene Set 8.804e-10 129 2.279e-08 9 Genes annotated by the GO term GO:0030529. A macromolecular complex containing both protein and RNA molecules. www.broad.mit.e...
Broad NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 2.165e-09 613 4.586e-08 10 Genes annotated by the GO term GO:0043228. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad INTRACELLULAR_NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 2.165e-09 613 4.586e-08 10 Genes annotated by the GO term GO:0043232. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad NUCLEOLUS View Gene Set 1.402e-08 116 2.723e-07 12 Genes annotated by the GO term GO:0005730. A small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA the processing of this RNA into 5.8S 18S and 28S components of ribosomal RNA and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. www.broad.mit.e...
Broad CHROMOSOME View Gene Set 1.813e-08 122 3.249e-07 13 Genes annotated by the GO term GO:0005694. A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad CHROMOSOMAL_PART View Gene Set 8.005e-08 95 1.332e-06 14 Genes annotated by the GO term GO:0044427. Any constituent part of a chromosome a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad CHROMOSOMEPERICENTRIC_REGION View Gene Set 8.66e-08 31 1.345e-06 15 Genes annotated by the GO term GO:0000775. The central region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes this region corresponds to a single area of the chromosome whereas in holocentric chromosomes it is evenly distributed along the chromosome. www.broad.mit.e...
Broad NUCLEOPLASM View Gene Set 1.374e-07 266 2.001e-06 16 Genes annotated by the GO term GO:0005654. That part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad SPINDLE View Gene Set 4.329e-07 37 5.933e-06 17 Genes annotated by the GO term GO:0005819. The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. www.broad.mit.e...
Broad PROTEIN_COMPLEX View Gene Set 1.021e-06 799 1.322e-05 18 Genes annotated by the GO term GO:0043234. Any protein group composed of two or more subunits which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad MITOCHONDRION View Gene Set 1.311e-06 335 1.607e-05 19 Genes annotated by the GO term GO:0005739. A semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad MICROTUBULE_CYTOSKELETON View Gene Set 1.475e-06 146 1.719e-05 20 Genes annotated by the GO term GO:0015630. The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. www.broad.mit.e...
Broad MICROTUBULE View Gene Set 1.691e-06 31 1.794e-05 21 Genes annotated by the GO term GO:0005874. Any of the long generally straight hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation e.g. in the spindle. www.broad.mit.e...
Broad SPLICEOSOME View Gene Set 1.694e-06 44 1.794e-05 21 Genes annotated by the GO term GO:0005681. A ribonucleoprotein complex containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. www.broad.mit.e...
Broad MICROTUBULE_ORGANIZING_CENTER View Gene Set 2.027e-06 64 2.054e-05 23 Genes annotated by the GO term GO:0005815. A region in a eukaryotic cell such as a centrosome or basal body from which microtubules grow. www.broad.mit.e...
Broad ENVELOPE View Gene Set 4.723e-06 165 4.401e-05 24 Genes annotated by the GO term GO:0031975. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers and may include a cell wall layer also includes the space between layers. www.broad.mit.e...
Broad ORGANELLE_ENVELOPE View Gene Set 4.723e-06 165 4.401e-05 24 Genes annotated by the GO term GO:0031967. A double membrane structure enclosing an organelle including two lipid bilayers and the region between them. In some cases an organelle envelope may have more than two membranes. www.broad.mit.e...
Broad MITOCHONDRIAL_PART View Gene Set 4.934e-06 140 4.421e-05 26 Genes annotated by the GO term GO:0044429. Any constituent part of a mitochondrion a semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad KINETOCHORE View Gene Set 5.409e-06 25 4.668e-05 27 Genes annotated by the GO term GO:0000776. A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. www.broad.mit.e...
Broad CONDENSED_CHROMOSOME View Gene Set 1.117e-05 32 9.295e-05 28 Genes annotated by the GO term GO:0000793. A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. www.broad.mit.e...
Broad PROTEASOME_COMPLEX View Gene Set 1.402e-05 23 0.0001126 29 Genes annotated by the GO term GO:0000502. A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. www.broad.mit.e...
Broad SPINDLE_MICROTUBULE View Gene Set 2.095e-05 15 0.0001627 30 Genes annotated by the GO term GO:0005876. Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. www.broad.mit.e...
Broad NUCLEOPLASM_PART View Gene Set 2.486e-05 202 0.0001868 31 Genes annotated by the GO term GO:0044451. Any constituent part of the nucleoplasm that part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad CENTROSOME View Gene Set 3.195e-05 55 0.0002326 32 Genes annotated by the GO term GO:0005813. A structure comprised of a core structure (in most organisms a pair of centrioles) and peripheral material from which a microtubule-based structure such as a spindle apparatus is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells though in animal cells it changes continually during the cell-division cycle. www.broad.mit.e...
Broad NUCLEOLAR_PART View Gene Set 3.368e-05 16 0.0002378 33 Genes annotated by the GO term GO:0044452. Any constituent part of a nucleolus a small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE_PART View Gene Set 6.423e-05 40 0.0004402 34 Genes annotated by the GO term GO:0044453. Any constituent part of the nuclear membrane the envelope that surrounds the nucleus of eukaryotic cells. www.broad.mit.e...
Broad PORE_COMPLEX View Gene Set 8.457e-05 34 0.000563 35 Genes annotated by the GO term GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids. www.broad.mit.e...
Broad SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 0.0001013 20 0.0006557 36 Genes annotated by the GO term GO:0030532. A complex composed of RNA of the small nuclear RNA (snRNA) class and protein found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain e.g. U1 snRNP or U4/U6 snRNP. Many but not all of these complexes are involved in splicing of nuclear mRNAs. www.broad.mit.e...
Broad NUCLEAR_PORE View Gene Set 0.0001087 29 0.0006846 37 Genes annotated by the GO term GO:0005643. Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell where the inner and outer nuclear membranes are joined. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE View Gene Set 0.0001682 48 0.001031 38 Genes annotated by the GO term GO:0031965. Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. www.broad.mit.e...
Broad TRANSCRIPTION_FACTOR_COMPLEX View Gene Set 0.000183 84 0.001093 39 Genes annotated by the GO term GO:0005667. Any complex distinct from RNA polymerase including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences and regulating transcription. www.broad.mit.e...
Broad MITOCHONDRIAL_OUTER_MEMBRANE View Gene Set 0.0002336 18 0.001361 40 Genes annotated by the GO term GO:0005741. The outer i.e. cytoplasm-facing lipid bilayer of the mitochondrial envelope. www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE View Gene Set 0.0002629 85 0.001458 41 Genes annotated by the GO term GO:0031966. Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad OUTER_MEMBRANE View Gene Set 0.0002618 25 0.001458 41 Genes annotated by the GO term GO:0019867. The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. www.broad.mit.e...
Broad ORGANELLE_OUTER_MEMBRANE View Gene Set 0.0003269 24 0.001771 43 Genes annotated by the GO term GO:0031968. The outer i.e. cytoplasm-facing lipid bilayer of an organelle envelope. www.broad.mit.e...
Broad SPINDLE_POLE View Gene Set 0.0003353 17 0.001776 44 Genes annotated by the GO term GO:0000922. Either of the ends of a spindle where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules spindle microtubules and astral microtubules. www.broad.mit.e...
Broad NUCLEAR_ENVELOPE View Gene Set 0.0004255 71 0.002203 45 Genes annotated by the GO term GO:0005635. The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space a gap of width 20-40 nm (also called the perinuclear space). www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE_PART View Gene Set 0.0005712 52 0.002893 46 Genes annotated by the GO term GO:0044455. Any constituent part of the mitochondrial membrane either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad MITOCHONDRIAL_ENVELOPE View Gene Set 0.0006 95 0.002974 47 Genes annotated by the GO term GO:0005740. The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. www.broad.mit.e...
Broad MITOCHONDRIAL_MATRIX View Gene Set 0.0008621 46 0.004099 48 Genes annotated by the GO term GO:0005759. The gel-like material with considerable fine structure that lies in the matrix space or lumen of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and in some organisms the enzymes concerned with fatty-acid oxidation. www.broad.mit.e...
Broad MITOCHONDRIAL_LUMEN View Gene Set 0.0008621 46 0.004099 48 Genes annotated by the GO term GO:0031980. The volume enclosed by the mitochondrial inner membrane. www.broad.mit.e...
Broad CONDENSED_NUCLEAR_CHROMOSOME View Gene Set 0.0009141 17 0.00426 50 Genes annotated by the GO term GO:0000794. A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus. www.broad.mit.e...
Broad DNA_DIRECTED_RNA_POLYMERASEII_HOLOENZYME View Gene Set 0.001017 65 0.004644 51 Genes annotated by the GO term GO:0016591. Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA D E F and H which are required for promoter recognition and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. www.broad.mit.e...
Broad CYTOSKELETAL_PART View Gene Set 0.002017 231 0.009038 52 Genes annotated by the GO term GO:0044430. Any constituent part of the cytoskeleton a cellular scaffolding or skeleton that maintains cell shape enables some cell motion (using structures such as flagella and cilia) and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments microfilaments microtubules and the microtrabecular lattice. www.broad.mit.e...
Broad HETEROGENEOUS_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 0.002702 9 0.01188 53 Genes annotated by the GO term GO:0030530. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II that which is translated into protein) with protein which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. www.broad.mit.e...
Broad ORGANELLAR_RIBOSOME View Gene Set 0.002953 22 0.01251 54 Genes annotated by the GO term GO:0000313. A ribosome contained within a subcellular organelle. www.broad.mit.e...
Broad MITOCHONDRIAL_RIBOSOME View Gene Set 0.002953 22 0.01251 54 Genes annotated by the GO term GO:0005761. A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME View Gene Set 0.003636 53 0.01513 56 Genes annotated by the GO term GO:0000228. A chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad MICROTUBULE_ORGANIZING_CENTER_PART View Gene Set 0.005337 19 0.02181 57 Genes annotated by the GO term GO:0044450. Any constituent part of a microtubule organizing center a region in a eukaryotic cell such as a centrosome or basal body from which microtubules grow. www.broad.mit.e...
Broad EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX View Gene Set 0.00545 10 0.02189 58 Genes annotated by the GO term GO:0005852. A complex of several polypeptides that plays at least two important roles in protein synthesis: First eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. www.broad.mit.e...
Broad RIBOSOMAL_SUBUNIT View Gene Set 0.006471 20 0.02555 59 Genes annotated by the GO term GO:0033279. Either of the two ribonucleoprotein complexes that associate to form a ribosome. www.broad.mit.e...
Broad ORGANELLE_INNER_MEMBRANE View Gene Set 0.008775 74 0.03408 60 Genes annotated by the GO term GO:0019866. The inner i.e. lumen-facing lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME_PART View Gene Set 0.01204 33 0.046 61 Genes annotated by the GO term GO:0044454. Any constituent part of a nuclear chromosome a chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad MEDIATOR_COMPLEX View Gene Set 0.0131 18 0.04923 62 Genes annotated by the GO term GO:0000119. A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription. www.broad.mit.e...

Gene Set Collection: Broad.c5.MF

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad HELICASE_ACTIVITY View Gene Set 1.96e-06 49 0.000389 1 Genes annotated by the GO term GO:0004386. Catalysis of the unwinding of a DNA or RNA duplex. www.broad.mit.e...
Broad RNA_BINDING View Gene Set 1.965e-06 236 0.000389 1 Genes annotated by the GO term GO:0003723. Interacting selectively with an RNA molecule or a portion thereof. www.broad.mit.e...
Broad RNA_HELICASE_ACTIVITY View Gene Set 4.214e-06 24 0.0004172 3 Genes annotated by the GO term GO:0003724. Catalysis of the unwinding of an RNA helix. www.broad.mit.e...
Broad ATP_DEPENDENT_HELICASE_ACTIVITY View Gene Set 4.12e-06 26 0.0004172 3 Genes annotated by the GO term GO:0008026. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. www.broad.mit.e...
Broad RNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 1.34e-05 18 0.001061 5 Genes annotated by the GO term GO:0008186. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of RNA; drives another reaction. www.broad.mit.e...
Broad ATP_DEPENDENT_RNA_HELICASE_ACTIVITY View Gene Set 1.776e-05 17 0.001172 6 Genes annotated by the GO term GO:0004004. Catalysis of the reaction: ATP + H2O = ADP + phosphate driving the unwinding of an RNA helix. www.broad.mit.e...
Broad TRANSLATION_INITIATION_FACTOR_ACTIVITY View Gene Set 6.951e-05 24 0.003933 7 Genes annotated by the GO term GO:0003743. Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. www.broad.mit.e...
Broad TRANSLATION_FACTOR_ACTIVITY_NUCLEIC_ACID_BINDING View Gene Set 0.0002303 39 0.0114 8 Genes annotated by the GO term GO:0008135. Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad DNA_HELICASE_ACTIVITY View Gene Set 0.0004157 24 0.01829 9 Genes annotated by the GO term GO:0003678. Catalysis of the unwinding of a DNA duplex. www.broad.mit.e...
Broad TRANSLATION_REGULATOR_ACTIVITY View Gene Set 0.0005516 41 0.02184 10 Genes annotated by the GO term GO:0045182. Any substance involved in the initiation activation perpetuation repression or termination of polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad GENERAL_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY View Gene Set 0.000721 32 0.02596 11 Genes annotated by the GO term GO:0016251. Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB TFIID TFIIE TFIIF TFIIH and TATA-binding protein (TBF). www.broad.mit.e...
Broad RNA_SPLICING_FACTOR_ACTIVITYTRANSESTERIFICATION_MECHANISM View Gene Set 0.0007973 14 0.02631 12 Genes annotated by the GO term GO:0031202. An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced. www.broad.mit.e...
Broad DNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 0.0008813 22 0.02684 13 Genes annotated by the GO term GO:0008094. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. www.broad.mit.e...
Broad ENDONUCLEASE_ACTIVITY_GO_0016893 View Gene Set 0.0009694 11 0.02742 14 Genes annotated by the GO term GO:0016893. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. www.broad.mit.e...

Gene Set Collection: PMID

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
PMID 15635413 View Gene Set 1.029e-28 421 2.581e-25 1 Nucleolar proteome dynamics. www.ncbi.nlm.ni...
PMID 12429849 View Gene Set 2.888e-22 106 3.621e-19 2 Functional proteomic analysis of human nucleolus. www.ncbi.nlm.ni...
PMID 11790298 View Gene Set 7.047e-22 208 5.004e-19 3 Directed proteomic analysis of the human nucleolus. www.ncbi.nlm.ni...
PMID 16565220 View Gene Set 7.985e-22 210 5.004e-19 3 Phosphoproteome analysis of the human mitotic spindle. www.ncbi.nlm.ni...
PMID 17643375 View Gene Set 1.149e-19 391 5.763e-17 5 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. www.ncbi.nlm.ni...
PMID 12226669 View Gene Set 6.85e-16 108 2.862e-13 6 Comprehensive proteomic analysis of the human spliceosome. www.ncbi.nlm.ni...
PMID 15302935 View Gene Set 2.143e-13 773 7.675e-11 7 Large-scale characterization of HeLa cell nuclear phosphoproteins. www.ncbi.nlm.ni...
PMID 16964243 View Gene Set 1.752e-12 504 5.49e-10 8 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. www.ncbi.nlm.ni...
PMID 11991638 View Gene Set 1.848e-11 74 5.147e-09 9 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. www.ncbi.nlm.ni...
PMID 11285280 View Gene Set 2.157e-11 62 5.409e-09 10 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. www.ncbi.nlm.ni...
PMID 12706105 View Gene Set 8.869e-11 182 2.021e-08 11 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. www.ncbi.nlm.ni...
PMID 20508983 View Gene Set 3.08e-10 102 6.434e-08 12 Centrosome-related genes genetic variation and risk of breast cancer. www.ncbi.nlm.ni...
PMID 18162579 View Gene Set 6.935e-10 22 1.337e-07 13 Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. www.ncbi.nlm.ni...
PMID 12791985 View Gene Set 7.61e-10 37 1.363e-07 14 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. www.ncbi.nlm.ni...
PMID 15029244 View Gene Set 3.006e-09 57 5.025e-07 15 Mammalian Cdh1/Fzr mediates its own degradation. www.ncbi.nlm.ni...
PMID 12221128 View Gene Set 9.407e-09 70 1.474e-06 16 Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. www.ncbi.nlm.ni...
PMID 12791267 View Gene Set 1.363e-08 50 2.01e-06 17 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. www.ncbi.nlm.ni...
PMID 12171929 View Gene Set 2.379e-08 31 3.237e-06 18 A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. www.ncbi.nlm.ni...
PMID 15231747 View Gene Set 2.453e-08 212 3.237e-06 18 A protein interaction framework for human mRNA degradation. www.ncbi.nlm.ni...
PMID 11076968 View Gene Set 5.704e-08 62 6.057e-06 20 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. www.ncbi.nlm.ni...
PMID 11543634 View Gene Set 5.798e-08 58 6.057e-06 20 The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. www.ncbi.nlm.ni...
PMID 12852856 View Gene Set 5.704e-08 61 6.057e-06 20 Polo-like kinase 1 regulates Nlp a centrosome protein involved in microtubule nucleation. www.ncbi.nlm.ni...
PMID 16462731 View Gene Set 5.704e-08 62 6.057e-06 20 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. www.ncbi.nlm.ni...
PMID 7790358 View Gene Set 5.704e-08 61 6.057e-06 20 Cell cycle regulation of the activity and subcellular localization of Plk1 a human protein kinase implicated in mitotic spindle function. www.ncbi.nlm.ni...
PMID 17363900 View Gene Set 6.833e-08 14 6.852e-06 25 The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. www.ncbi.nlm.ni...
PMID 19237606 View Gene Set 7.271e-08 84 7.011e-06 26 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. www.ncbi.nlm.ni...
PMID 14559993 View Gene Set 1.112e-07 51 1.032e-05 27 Regulation of alternative splicing by SRrp86 and its interacting proteins. www.ncbi.nlm.ni...
PMID 20496165 View Gene Set 1.285e-07 68 1.151e-05 28 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. www.ncbi.nlm.ni...
PMID 14966270 View Gene Set 1.598e-07 19 1.382e-05 29 Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. www.ncbi.nlm.ni...
PMID 10893419 View Gene Set 2.97e-07 41 2.051e-05 30 Degradation of HIV-1 integrase by the N-end rule pathway. www.ncbi.nlm.ni...
PMID 12419264 View Gene Set 2.97e-07 41 2.051e-05 30 The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. www.ncbi.nlm.ni...
PMID 12719574 View Gene Set 3.518e-07 42 2.051e-05 30 Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. www.ncbi.nlm.ni...
PMID 12750511 View Gene Set 3.518e-07 42 2.051e-05 30 Hypermutation of HIV-1 DNA in the absence of the Vif protein. www.ncbi.nlm.ni...
PMID 12830140 View Gene Set 3.518e-07 42 2.051e-05 30 DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. www.ncbi.nlm.ni...
PMID 12840737 View Gene Set 3.518e-07 42 2.051e-05 30 Good to CU. www.ncbi.nlm.ni...
PMID 12914693 View Gene Set 3.518e-07 42 2.051e-05 30 Death by deamination: a novel host restriction system for HIV-1. www.ncbi.nlm.ni...
PMID 12920286 View Gene Set 3.518e-07 42 2.051e-05 30 Virology. Weapons of mutational destruction. www.ncbi.nlm.ni...
PMID 12963728 View Gene Set 2.557e-07 21 2.051e-05 30 Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. www.ncbi.nlm.ni...
PMID 14550573 View Gene Set 2.97e-07 41 2.051e-05 30 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. www.ncbi.nlm.ni...
PMID 14614829 View Gene Set 3.518e-07 42 2.051e-05 30 The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. www.ncbi.nlm.ni...
PMID 9079628 View Gene Set 2.97e-07 41 2.051e-05 30 HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. www.ncbi.nlm.ni...
PMID 9811770 View Gene Set 3.518e-07 42 2.051e-05 30 An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. www.ncbi.nlm.ni...
PMID 9846577 View Gene Set 3.518e-07 42 2.051e-05 30 Evidence for a newly discovered cellular anti-HIV-1 phenotype. www.ncbi.nlm.ni...
PMID 12859895 View Gene Set 4.909e-07 47 2.797e-05 44 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. www.ncbi.nlm.ni...
PMID 8811196 View Gene Set 5.021e-07 37 2.797e-05 45 Structure and functions of the 20S and 26S proteasomes. www.ncbi.nlm.ni...
PMID 19468067 View Gene Set 7.27e-07 10 3.962e-05 46 Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. www.ncbi.nlm.ni...
PMID 11719186 View Gene Set 8.681e-07 17 4.405e-05 47 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. www.ncbi.nlm.ni...
PMID 12167863 View Gene Set 1.002e-06 43 4.405e-05 47 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. www.ncbi.nlm.ni...
PMID 12808465 View Gene Set 1.002e-06 43 4.405e-05 47 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. www.ncbi.nlm.ni...
PMID 12808466 View Gene Set 1.002e-06 43 4.405e-05 47 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. www.ncbi.nlm.ni...
PMID 12809610 View Gene Set 1.002e-06 43 4.405e-05 47 DNA deamination mediates innate immunity to retroviral infection. www.ncbi.nlm.ni...
PMID 12970355 View Gene Set 1.002e-06 43 4.405e-05 47 The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. www.ncbi.nlm.ni...
PMID 14527406 View Gene Set 1.002e-06 43 4.405e-05 47 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. www.ncbi.nlm.ni...
PMID 14528300 View Gene Set 1.002e-06 43 4.405e-05 47 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. www.ncbi.nlm.ni...
PMID 14528301 View Gene Set 1.002e-06 43 4.405e-05 47 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. www.ncbi.nlm.ni...
PMID 14557625 View Gene Set 1.002e-06 43 4.405e-05 47 The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15) a cellular inhibitor of virus infectivity. www.ncbi.nlm.ni...
PMID 20522537 View Gene Set 9.309e-07 73 4.405e-05 47 Variation within DNA repair pathway genes and risk of multiple sclerosis. www.ncbi.nlm.ni...
PMID 14564014 View Gene Set 1.05e-06 47 4.539e-05 58 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. www.ncbi.nlm.ni...
PMID 20085707 View Gene Set 1.243e-06 42 5.284e-05 59 Aire's partners in the molecular control of immunological tolerance. www.ncbi.nlm.ni...
PMID 11279123 View Gene Set 1.267e-06 31 5.295e-05 60 The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 16622419 View Gene Set 1.751e-06 16 7.198e-05 61 The human CENP-A centromeric nucleosome-associated complex. www.ncbi.nlm.ni...
PMID 16622420 View Gene Set 1.876e-06 14 7.588e-05 62 The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. www.ncbi.nlm.ni...
PMID 9731529 View Gene Set 1.951e-06 24 7.762e-05 63 Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. www.ncbi.nlm.ni...
PMID 12930902 View Gene Set 2.794e-06 11 0.0001094 64 The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. www.ncbi.nlm.ni...
PMID 15707391 View Gene Set 3.239e-06 23 0.0001249 65 DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. www.ncbi.nlm.ni...
PMID 15146077 View Gene Set 4.403e-06 32 0.0001669 66 The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. www.ncbi.nlm.ni...
PMID 15196461 View Gene Set 4.461e-06 11 0.0001669 66 The highly conserved and multifunctional NuA4 HAT complex. www.ncbi.nlm.ni...
PMID 14499622 View Gene Set 5.364e-06 53 0.0001949 68 Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation cell signaling oxidative metabolism and cellular transport. www.ncbi.nlm.ni...
PMID 18270339 View Gene Set 5.356e-06 57 0.0001949 68 Comprehensive analysis of DNA repair gene variants and risk of meningioma. www.ncbi.nlm.ni...
PMID 15009096 View Gene Set 8.948e-06 39 0.0003205 70 Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex while BMI-1 is transiently co-localized with the centromeric region in interphase. www.ncbi.nlm.ni...
PMID 19710015 View Gene Set 9.268e-06 48 0.0003273 71 The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. www.ncbi.nlm.ni...
PMID 11812149 View Gene Set 1.23e-05 13 0.0004282 72 Protein-protein interactions of hCsl4p with other human exosome subunits. www.ncbi.nlm.ni...
PMID 15647280 View Gene Set 1.247e-05 17 0.0004282 72 The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. www.ncbi.nlm.ni...
PMID 15691386 View Gene Set 1.312e-05 12 0.0004384 74 HIV-1 Tat protein enhances microtubule polymerization. www.ncbi.nlm.ni...
PMID 15698476 View Gene Set 1.312e-05 12 0.0004384 74 HIV-1 Tat apoptosis and the mitochondria: a tubulin link? www.ncbi.nlm.ni...
PMID 15331610 View Gene Set 1.92e-05 12 0.0006333 76 The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. www.ncbi.nlm.ni...
PMID 15592455 View Gene Set 2.014e-05 317 0.0006559 77 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. www.ncbi.nlm.ni...
PMID 11095689 View Gene Set 2.078e-05 17 0.0006674 78 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. www.ncbi.nlm.ni...
PMID 15226314 View Gene Set 2.103e-05 20 0.0006674 78 Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. www.ncbi.nlm.ni...
PMID 19209188 View Gene Set 2.161e-05 13 0.0006773 80 Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. www.ncbi.nlm.ni...
PMID 15504738 View Gene Set 2.229e-05 19 0.00069 81 Genes affecting the cell cycle growth maintenance and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. www.ncbi.nlm.ni...
PMID 18954305 View Gene Set 2.659e-05 13 0.000813 82 Structural basis and specificity of human otubain 1-mediated deubiquitination. www.ncbi.nlm.ni...
PMID 19596235 View Gene Set 2.741e-05 85 0.0008279 83 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. www.ncbi.nlm.ni...
PMID 20226869 View Gene Set 2.938e-05 25 0.0008767 84 Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. www.ncbi.nlm.ni...
PMID 11310559 View Gene Set 3.125e-05 17 0.0009217 85 Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. www.ncbi.nlm.ni...
PMID 12234937 View Gene Set 3.226e-05 34 0.0009405 86 Characterization of novel SF3b and 17S U2 snRNP proteins including a human Prp5p homologue and an SF3b DEAD-box protein. www.ncbi.nlm.ni...
PMID 11742988 View Gene Set 3.31e-05 20 0.0009539 87 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. www.ncbi.nlm.ni...
PMID 11110791 View Gene Set 4.237e-05 12 0.001193 88 Three novel components of the human exosome. www.ncbi.nlm.ni...
PMID 12419256 View Gene Set 4.196e-05 12 0.001193 88 Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. www.ncbi.nlm.ni...
PMID 16236267 View Gene Set 4.29e-05 77 0.001195 90 Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. www.ncbi.nlm.ni...
PMID 10601273 View Gene Set 4.5e-05 21 0.00124 91 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein whereas export is due to a nuclear export signal sequence in glucokinase. www.ncbi.nlm.ni...
PMID 12614612 View Gene Set 4.85e-05 19 0.001322 92 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. www.ncbi.nlm.ni...
PMID 11535616 View Gene Set 7.05e-05 18 0.00188 93 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1 BUB3 CDC20 and MAD2. www.ncbi.nlm.ni...
PMID 12228227 View Gene Set 7.124e-05 30 0.00188 93 Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. www.ncbi.nlm.ni...
PMID 14593737 View Gene Set 7.05e-05 18 0.00188 93 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. www.ncbi.nlm.ni...
PMID 12045100 View Gene Set 8.309e-05 18 0.00217 96 DNA replication in eukaryotic cells. www.ncbi.nlm.ni...
PMID 15502821 View Gene Set 9.263e-05 12 0.002394 97 A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. www.ncbi.nlm.ni...
PMID 10793135 View Gene Set 9.838e-05 18 0.002512 98 Mitotic regulation of the APC activator proteins CDC20 and CDH1. www.ncbi.nlm.ni...
PMID 12486001 View Gene Set 9.918e-05 15 0.002512 98 HIV-1 Tat targets microtubules to induce apoptosis a process promoted by the pro-apoptotic Bcl-2 relative Bim. www.ncbi.nlm.ni...
PMID 12788944 View Gene Set 0.0001317 11 0.003301 100 The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. www.ncbi.nlm.ni...
PMID 10608806 View Gene Set 0.0001534 25 0.003808 101 Substrate specificities and identification of putative substrates of ATM kinase family members. www.ncbi.nlm.ni...
PMID 7494303 View Gene Set 0.0001664 12 0.00409 102 Mutational analysis of cell cycle arrest nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. www.ncbi.nlm.ni...
PMID 10908577 View Gene Set 0.0001688 14 0.00411 103 HIV-1 rev depolymerizes microtubules to form stable bilayered rings. www.ncbi.nlm.ni...
PMID 17148452 View Gene Set 0.0001721 87 0.004147 104 Characterization of the interactome of the human MutL homologues MLH1 PMS1 and PMS2. www.ncbi.nlm.ni...
PMID 10436018 View Gene Set 0.0002124 15 0.005023 105 The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. www.ncbi.nlm.ni...
PMID 11125146 View Gene Set 0.0002114 10 0.005023 105 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. www.ncbi.nlm.ni...
PMID 14743216 View Gene Set 0.0002325 132 0.005447 107 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. www.ncbi.nlm.ni...
PMID 9878398 View Gene Set 0.0002347 13 0.005447 108 Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. www.ncbi.nlm.ni...
PMID 11551941 View Gene Set 0.0002614 26 0.006011 109 The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 8590280 View Gene Set 0.0002662 41 0.006066 110 Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. www.ncbi.nlm.ni...
PMID 20193073 View Gene Set 0.0002713 52 0.006127 111 Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. www.ncbi.nlm.ni...
PMID 18206972 View Gene Set 0.0003271 12 0.007322 112 A TFTC/STAGA module mediates histone H2A and H2B deubiquitination coactivates nuclear receptors and counteracts heterochromatin silencing. www.ncbi.nlm.ni...
PMID 15096576 View Gene Set 0.0003409 14 0.007563 113 Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. www.ncbi.nlm.ni...
PMID 16716197 View Gene Set 0.000397 10 0.008731 114 Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. www.ncbi.nlm.ni...
PMID 11531413 View Gene Set 0.0004053 27 0.008836 115 HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. www.ncbi.nlm.ni...
PMID 19536649 View Gene Set 0.0004101 15 0.008864 116 The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. www.ncbi.nlm.ni...
PMID 18427977 View Gene Set 0.0004463 17 0.009401 117 High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. www.ncbi.nlm.ni...
PMID 18635682 View Gene Set 0.0004463 17 0.009401 117 Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. www.ncbi.nlm.ni...
PMID 20458436 View Gene Set 0.0004463 17 0.009401 117 Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. www.ncbi.nlm.ni...
PMID 11416179 View Gene Set 0.0004683 12 0.009783 120 All kinesin superfamily protein KIF genes in mouse and human. www.ncbi.nlm.ni...
PMID 14532270 View Gene Set 0.0004727 12 0.009795 121 A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. www.ncbi.nlm.ni...
PMID 18997788 View Gene Set 0.000478 10 0.009822 122 The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. www.ncbi.nlm.ni...
PMID 10851237 View Gene Set 0.0005012 11 0.01013 123 Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). www.ncbi.nlm.ni...
PMID 12601814 View Gene Set 0.0004991 12 0.01013 123 Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. www.ncbi.nlm.ni...
PMID 10318877 View Gene Set 0.0005519 10 0.01107 125 Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. www.ncbi.nlm.ni...
PMID 16195237 View Gene Set 0.0006114 20 0.01217 126 Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. www.ncbi.nlm.ni...
PMID 19690177 View Gene Set 0.0006307 31 0.01245 127 Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. www.ncbi.nlm.ni...
PMID 11101529 View Gene Set 0.0006489 34 0.01271 128 Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. www.ncbi.nlm.ni...
PMID 14667819 View Gene Set 0.0006712 112 0.01304 129 Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. www.ncbi.nlm.ni...
PMID 12070128 View Gene Set 0.0006846 17 0.0131 130 Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. www.ncbi.nlm.ni...
PMID 19450687 View Gene Set 0.0006801 11 0.0131 130 High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. www.ncbi.nlm.ni...
PMID 15324660 View Gene Set 0.0008392 242 0.01594 132 Proteomic functional and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. www.ncbi.nlm.ni...
PMID 11931757 View Gene Set 0.00085 22 0.01602 133 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. www.ncbi.nlm.ni...
PMID 15078818 View Gene Set 0.0008846 11 0.01643 134 Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. www.ncbi.nlm.ni...
PMID 16702407 View Gene Set 0.0008846 11 0.01643 134 DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. www.ncbi.nlm.ni...
PMID 14983052 View Gene Set 0.0009152 391 0.01687 136 The human olfactory receptor gene family. www.ncbi.nlm.ni...
PMID 10766737 View Gene Set 0.000947 11 0.01733 137 Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. www.ncbi.nlm.ni...
PMID 9852112 View Gene Set 0.0009676 20 0.01758 138 Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. www.ncbi.nlm.ni...
PMID 11076961 View Gene Set 0.001024 14 0.01833 139 Characterization of vertebrate cohesin complexes and their regulation in prophase. www.ncbi.nlm.ni...
PMID 15130578 View Gene Set 0.00102 22 0.01833 139 Why do cells need an assembly machine for RNA-protein complexes? www.ncbi.nlm.ni...
PMID 15232106 View Gene Set 0.001059 30 0.01882 141 Self-assembling protein microarrays. www.ncbi.nlm.ni...
PMID 11914277 View Gene Set 0.001222 38 0.02157 142 miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. www.ncbi.nlm.ni...
PMID 19858780 View Gene Set 0.001235 10 0.02165 143 Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis. www.ncbi.nlm.ni...
PMID 9111189 View Gene Set 0.001255 16 0.02186 144 Which DNA polymerases are used for DNA-repair in eukaryotes? www.ncbi.nlm.ni...
PMID 8467795 View Gene Set 0.001323 15 0.02287 145 Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. www.ncbi.nlm.ni...
PMID 11157797 View Gene Set 0.001344 76 0.02297 146 Sequence structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. www.ncbi.nlm.ni...
PMID 11205743 View Gene Set 0.001347 15 0.02297 146 Polo-like kinase interacts with proteasomes and regulates their activity. www.ncbi.nlm.ni...
PMID 11714285 View Gene Set 0.001479 11 0.02408 148 The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. www.ncbi.nlm.ni...
PMID 16055448 View Gene Set 0.001479 11 0.02408 148 The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. www.ncbi.nlm.ni...
PMID 8052601 View Gene Set 0.001479 11 0.02408 148 Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. www.ncbi.nlm.ni...
PMID 8078941 View Gene Set 0.001479 11 0.02408 148 Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. www.ncbi.nlm.ni...
PMID 8188258 View Gene Set 0.001479 11 0.02408 148 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. www.ncbi.nlm.ni...
PMID 8449960 View Gene Set 0.001479 11 0.02408 148 Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. www.ncbi.nlm.ni...
PMID 9278442 View Gene Set 0.001479 11 0.02408 148 Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant. www.ncbi.nlm.ni...
PMID 11799066 View Gene Set 0.001549 21 0.02505 155 Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. www.ncbi.nlm.ni...
PMID 11124703 View Gene Set 0.001579 18 0.02538 156 Characterization of 16 novel human genes showing high similarity to yeast sequences. www.ncbi.nlm.ni...
PMID 11829477 View Gene Set 0.001797 13 0.02869 157 Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. www.ncbi.nlm.ni...
PMID 18063578 View Gene Set 0.001815 31 0.0288 158 The layered structure of human mitochondrial DNA nucleoids. www.ncbi.nlm.ni...
PMID 12482968 View Gene Set 0.001901 13 0.02997 159 Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. www.ncbi.nlm.ni...
PMID 15057824 View Gene Set 0.001949 274 0.03053 160 The DNA sequence and biology of human chromosome 19. www.ncbi.nlm.ni...
PMID 12575992 View Gene Set 0.002 11 0.03109 161 The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. www.ncbi.nlm.ni...
PMID 9121429 View Gene Set 0.002009 39 0.03109 161 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. www.ncbi.nlm.ni...
PMID 11402041 View Gene Set 0.002084 16 0.03203 163 Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. www.ncbi.nlm.ni...
PMID 17041588 View Gene Set 0.002096 19 0.03203 163 CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. www.ncbi.nlm.ni...
PMID 11073998 View Gene Set 0.002154 15 0.03272 165 TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. www.ncbi.nlm.ni...
PMID 16085932 View Gene Set 0.002263 18 0.03417 166 A novel evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. www.ncbi.nlm.ni...
PMID 18809582 View Gene Set 0.002459 25 0.03691 167 Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. www.ncbi.nlm.ni...
PMID 15461802 View Gene Set 0.002519 293 0.03756 168 A genome annotation-driven approach to cloning the human ORFeome. www.ncbi.nlm.ni...
PMID 18485873 View Gene Set 0.002532 13 0.03756 168 Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. www.ncbi.nlm.ni...
PMID 11406595 View Gene Set 0.002581 16 0.03807 170 UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. www.ncbi.nlm.ni...
PMID 20347428 View Gene Set 0.002607 14 0.03822 171 A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. www.ncbi.nlm.ni...
PMID 16359901 View Gene Set 0.00295 14 0.04251 172 Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. www.ncbi.nlm.ni...
PMID 9184228 View Gene Set 0.002949 21 0.04251 172 Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. www.ncbi.nlm.ni...
PMID 9334327 View Gene Set 0.002949 21 0.04251 172 The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. www.ncbi.nlm.ni...
PMID 12062430 View Gene Set 0.002991 17 0.04285 175 Identification of casein kinase Ialpha interacting protein partners. www.ncbi.nlm.ni...
PMID 14654843 View Gene Set 0.003051 26 0.04346 176 Proteomic characterization of the human centrosome by protein correlation profiling. www.ncbi.nlm.ni...
PMID 15931389 View Gene Set 0.003121 12 0.0442 177 Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. www.ncbi.nlm.ni...
PMID 19270065 View Gene Set 0.003263 11 0.04596 178 MRE11 complex links RECQ5 helicase to sites of DNA damage. www.ncbi.nlm.ni...
PMID 11500380 View Gene Set 0.003372 10 0.04723 179 A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. www.ncbi.nlm.ni...
PMID 19536092 View Gene Set 0.00342 55 0.04764 180 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. www.ncbi.nlm.ni...
PMID 15146057 View Gene Set 0.003557 10 0.04926 181 The entire Nup107-160 complex including three new members is targeted as one entity to kinetochores in mitosis. www.ncbi.nlm.ni...

Gene Set Collection: ChromosomalTiles5Mb

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null chr16_67.5-72.5Mb View Gene Set 7.453e-06 51 0.004421 1 Genomic tile: chr16 ; 67500001-72500001 Mb genome.ucsc.edu...
Null chr9_132.5-137.5Mb View Gene Set 7.936e-06 53 0.004421 1 Genomic tile: chr9 ; 132500001-137500001 Mb genome.ucsc.edu...
Null chr16_0-5Mb View Gene Set 1.3e-05 113 0.004826 3 Genomic tile: chr16 ; 1-5000001 Mb genome.ucsc.edu...
Null chr8_145-150Mb View Gene Set 2.542e-05 33 0.00708 4 Genomic tile: chr8 ; 145000001-150000001 Mb genome.ucsc.edu...
Null chr17_80-85Mb View Gene Set 3.675e-05 37 0.008187 5 Genomic tile: chr17 ; 80000001-85000001 Mb genome.ucsc.edu...
Null chr12_127.5-132.5Mb View Gene Set 7.65e-05 29 0.0137 6 Genomic tile: chr12 ; 127500001-132500001 Mb genome.ucsc.edu...
Null chr12_130-135Mb View Gene Set 0.0001107 19 0.0137 6 Genomic tile: chr12 ; 130000001-135000001 Mb genome.ucsc.edu...
Null chr17_77.5-82.5Mb View Gene Set 9.397e-05 54 0.0137 6 Genomic tile: chr17 ; 77500001-82500001 Mb genome.ucsc.edu...
Null chr8_142.5-147.5Mb View Gene Set 0.00011 64 0.0137 6 Genomic tile: chr8 ; 142500001-147500001 Mb genome.ucsc.edu...
Null chr9_125-130Mb View Gene Set 0.0002652 72 0.02954 10 Genomic tile: chr9 ; 125000001-130000001 Mb genome.ucsc.edu...
Null chr14_85-90Mb View Gene Set 0.0005501 18 0.04714 11 Genomic tile: chr14 ; 85000001-90000001 Mb genome.ucsc.edu...
Null chr18_0-5Mb View Gene Set 0.0005142 18 0.04714 11 Genomic tile: chr18 ; 1-5000001 Mb genome.ucsc.edu...
Null chr4_0-5Mb View Gene Set 0.0005323 45 0.04714 11 Genomic tile: chr4 ; 1-5000001 Mb genome.ucsc.edu...

Gene Set Collection: Prosite

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null PS51194 View Gene Set 1.458e-08 113 1.072e-05 1 HELICASE_CTER expasy.org/pros...
Null PS51192 View Gene Set 3.415e-08 112 1.255e-05 2 HELICASE_ATP_BIND_1 expasy.org/pros...
Null PS50102 View Gene Set 5.615e-08 229 1.376e-05 3 RRM expasy.org/pros...
Null PS50174 View Gene Set 9.308e-07 25 0.000171 4 G_PATCH expasy.org/pros...
Null PS50805 View Gene Set 1.217e-06 415 0.0001789 5 KRAB expasy.org/pros...
Null PS00227 View Gene Set 3.304e-06 26 0.0003469 6 TUBULIN expasy.org/pros...
Null PS51195 View Gene Set 2.832e-06 37 0.0003469 6 Q_MOTIF expasy.org/pros...
Null PS50082 View Gene Set 4.259e-06 233 0.0003913 8 WD_REPEATS_2 expasy.org/pros...
Null PS50294 View Gene Set 6.017e-06 245 0.0004914 9 WD_REPEATS_REGION expasy.org/pros...
Null PS00678 View Gene Set 6.261e-05 168 0.004602 10 WD_REPEATS_1 expasy.org/pros...
Null PS50862 View Gene Set 7.463e-05 18 0.004986 11 AA_TRNA_LIGASE_II expasy.org/pros...
Null PS00750 View Gene Set 0.000278 9 0.0146 12 TCP1_1 expasy.org/pros...
Null PS00751 View Gene Set 0.000278 9 0.0146 12 TCP1_2 expasy.org/pros...
Null PS00995 View Gene Set 0.000278 9 0.0146 12 TCP1_3 expasy.org/pros...
Null PS50833 View Gene Set 0.0003329 7 0.01631 15 BRIX expasy.org/pros...
Null PS00228 View Gene Set 0.000416 10 0.01899 16 TUBULIN_B_AUTOREG expasy.org/pros...
Null PS50067 View Gene Set 0.0004392 46 0.01899 16 KINESIN_MOTOR_DOMAIN2 expasy.org/pros...
Null PS50157 View Gene Set 0.0004782 811 0.01953 18 ZINC_FINGER_C2H2_2 expasy.org/pros...
Null PS00046 View Gene Set 0.0006047 21 0.02339 19 HISTONE_H2A expasy.org/pros...
Null PS00690 View Gene Set 0.0009182 24 0.03374 20 DEAH_ATP_HELICASE expasy.org/pros...

Gene Set Collection: ppi.BIND

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.E2F1 View Gene Set 0.000137 12 0.006471 1 Protein-protein-interaction for E2F1 www.ncbi.nlm.ni...
Null ppi.E2F4 View Gene Set 0.0001249 14 0.006471 1 Protein-protein-interaction for E2F4 www.ncbi.nlm.ni...
Null ppi.CBX5 View Gene Set 0.0001164 7 0.006471 1 Protein-protein-interaction for CBX5 www.ncbi.nlm.ni...
Null ppi.RAD51 View Gene Set 3.578e-05 7 0.006471 1 Protein-protein-interaction for RAD51 www.ncbi.nlm.ni...

Gene Set Collection: ppi.BioGRID

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.155871 View Gene Set 7.965e-19 236 1.83e-15 1 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.SRRM2 View Gene Set 2.11e-12 101 2.423e-09 2 Protein-protein-interaction for SRRM2 www.ncbi.nlm.ni...
Null ppi.MEPCE View Gene Set 9.341e-11 147 7.152e-08 3 Protein-protein-interaction for MEPCE www.ncbi.nlm.ni...
Null ppi.SRRM1 View Gene Set 3.455e-08 64 1.984e-05 4 Protein-protein-interaction for SRRM1 www.ncbi.nlm.ni...
Null ppi.GPN1 View Gene Set 9.352e-08 27 4.296e-05 5 Protein-protein-interaction for GPN1 www.ncbi.nlm.ni...
Null ppi.72462 View Gene Set 3.199e-07 42 0.0001225 6 Protein-protein-interaction for 72462 www.ncbi.nlm.ni...
Null ppi.CDT1 View Gene Set 6.81e-07 37 0.0002235 7 Protein-protein-interaction for CDT1 www.ncbi.nlm.ni...
Null ppi.PSMD14 View Gene Set 9.014e-07 16 0.0002588 8 Protein-protein-interaction for PSMD14 www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 1.522e-06 40 0.0003884 9 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.USP36 View Gene Set 2.977e-06 17 0.0006838 10 Protein-protein-interaction for USP36 www.ncbi.nlm.ni...
Null ppi.UCHL5 View Gene Set 3.481e-06 33 0.0007212 11 Protein-protein-interaction for UCHL5 www.ncbi.nlm.ni...
Null ppi.RPAP2 View Gene Set 3.768e-06 43 0.0007212 11 Protein-protein-interaction for RPAP2 www.ncbi.nlm.ni...
Null ppi.FANCA View Gene Set 6.554e-06 14 0.001158 13 Protein-protein-interaction for FANCA www.ncbi.nlm.ni...
Null ppi.PSMD6 View Gene Set 1.117e-05 21 0.001832 14 Protein-protein-interaction for PSMD6 www.ncbi.nlm.ni...
Null ppi.RRP1B View Gene Set 1.198e-05 21 0.001835 15 Protein-protein-interaction for RRP1B www.ncbi.nlm.ni...
Null ppi.CHTF18 View Gene Set 1.584e-05 13 0.002141 16 Protein-protein-interaction for CHTF18 www.ncbi.nlm.ni...
Null ppi.WRN View Gene Set 1.583e-05 14 0.002141 16 Protein-protein-interaction for WRN www.ncbi.nlm.ni...
Null ppi.RUVBL2 View Gene Set 1.936e-05 64 0.00234 18 Protein-protein-interaction for RUVBL2 www.ncbi.nlm.ni...
Null ppi.TERF2 View Gene Set 1.881e-05 9 0.00234 18 Protein-protein-interaction for TERF2 www.ncbi.nlm.ni...
Null ppi.KAT2A View Gene Set 2.953e-05 12 0.003392 20 Protein-protein-interaction for KAT2A www.ncbi.nlm.ni...
Null ppi.EIF3F View Gene Set 3.229e-05 22 0.003532 21 Protein-protein-interaction for EIF3F www.ncbi.nlm.ni...
Null ppi.RNU12-2P View Gene Set 4.129e-05 18 0.003952 22 Protein-protein-interaction for RNU12-2P www.ncbi.nlm.ni...
Null ppi.RNU11 View Gene Set 4.129e-05 18 0.003952 22 Protein-protein-interaction for RNU11 www.ncbi.nlm.ni...
Null ppi.USP14 View Gene Set 3.883e-05 22 0.003952 22 Protein-protein-interaction for USP14 www.ncbi.nlm.ni...
Null ppi.ING3 View Gene Set 4.582e-05 10 0.00421 25 Protein-protein-interaction for ING3 www.ncbi.nlm.ni...
Null ppi.C20orf20 View Gene Set 5.296e-05 15 0.004506 26 Protein-protein-interaction for C20orf20 www.ncbi.nlm.ni...
Null ppi.TP53BP1 View Gene Set 5.124e-05 13 0.004506 26 Protein-protein-interaction for TP53BP1 www.ncbi.nlm.ni...
Null ppi.RPAP3 View Gene Set 7.774e-05 29 0.006377 28 Protein-protein-interaction for RPAP3 www.ncbi.nlm.ni...
Null ppi.MYSM1 View Gene Set 0.0001012 13 0.008019 29 Protein-protein-interaction for MYSM1 www.ncbi.nlm.ni...
Null ppi.ORC6L View Gene Set 0.0001082 11 0.008181 30 Protein-protein-interaction for ORC6L www.ncbi.nlm.ni...
Null ppi.PRKDC View Gene Set 0.0001104 38 0.008181 30 Protein-protein-interaction for PRKDC www.ncbi.nlm.ni...
Null ppi.SF3B3 View Gene Set 0.0001424 16 0.01022 32 Protein-protein-interaction for SF3B3 www.ncbi.nlm.ni...
Null ppi.WBP4 View Gene Set 0.0001575 35 0.01069 33 Protein-protein-interaction for WBP4 www.ncbi.nlm.ni...
Null ppi.PAAF1 View Gene Set 0.0001582 20 0.01069 33 Protein-protein-interaction for PAAF1 www.ncbi.nlm.ni...
Null ppi.PSMD13 View Gene Set 0.0001891 20 0.01241 35 Protein-protein-interaction for PSMD13 www.ncbi.nlm.ni...
Null ppi.DPY30 View Gene Set 0.0002509 9 0.01601 36 Protein-protein-interaction for DPY30 www.ncbi.nlm.ni...
Null ppi.ORC3L View Gene Set 0.0002719 9 0.01688 37 Protein-protein-interaction for ORC3L www.ncbi.nlm.ni...
Null ppi.ATRIP View Gene Set 0.0003114 9 0.01882 38 Protein-protein-interaction for ATRIP www.ncbi.nlm.ni...
Null ppi.MGMT View Gene Set 0.0003538 28 0.02084 39 Protein-protein-interaction for MGMT www.ncbi.nlm.ni...
Null ppi.FEN1 View Gene Set 0.0003915 11 0.02248 40 Protein-protein-interaction for FEN1 www.ncbi.nlm.ni...
Null ppi.PRPF19 View Gene Set 0.0004092 9 0.02292 41 Protein-protein-interaction for PRPF19 www.ncbi.nlm.ni...
Null ppi.CHAF1A View Gene Set 0.0004195 19 0.02294 42 Protein-protein-interaction for CHAF1A www.ncbi.nlm.ni...
Null ppi.AURKA View Gene Set 0.0004421 9 0.02308 43 Protein-protein-interaction for AURKA www.ncbi.nlm.ni...
Null ppi.EIF3H View Gene Set 0.0004335 16 0.02308 43 Protein-protein-interaction for EIF3H www.ncbi.nlm.ni...
Null ppi.MIS12 View Gene Set 0.0004879 9 0.0249 45 Protein-protein-interaction for MIS12 www.ncbi.nlm.ni...
Null ppi.CLSPN View Gene Set 0.0005064 17 0.02529 46 Protein-protein-interaction for CLSPN www.ncbi.nlm.ni...
Null ppi.SUPT3H View Gene Set 0.0005411 14 0.02645 47 Protein-protein-interaction for SUPT3H www.ncbi.nlm.ni...
Null ppi.KHDRBS2 View Gene Set 0.0005862 46 0.02805 48 Protein-protein-interaction for KHDRBS2 www.ncbi.nlm.ni...
Null ppi.FAM173A View Gene Set 0.0006023 10 0.02823 49 Protein-protein-interaction for FAM173A www.ncbi.nlm.ni...
Null ppi.EIF3B View Gene Set 0.000652 10 0.02995 50 Protein-protein-interaction for EIF3B www.ncbi.nlm.ni...
Null ppi.RPA1 View Gene Set 0.0007034 23 0.03049 51 Protein-protein-interaction for RPA1 www.ncbi.nlm.ni...
Null ppi.SUMO2 View Gene Set 0.0006946 50 0.03049 51 Protein-protein-interaction for SUMO2 www.ncbi.nlm.ni...
Null ppi.GIYD2 View Gene Set 0.0006775 32 0.03049 51 Protein-protein-interaction for GIYD2 www.ncbi.nlm.ni...
Null ppi.SUPT16H View Gene Set 0.0007457 11 0.03172 54 Protein-protein-interaction for SUPT16H www.ncbi.nlm.ni...
Null ppi.RPAP1 View Gene Set 0.0008348 24 0.03486 55 Protein-protein-interaction for RPAP1 www.ncbi.nlm.ni...
Null ppi.MRE11A View Gene Set 0.0008694 13 0.03566 56 Protein-protein-interaction for MRE11A www.ncbi.nlm.ni...
Null ppi.SMNDC1 View Gene Set 0.00102 8 0.03841 57 Protein-protein-interaction for SMNDC1 www.ncbi.nlm.ni...
Null ppi.NUP43 View Gene Set 0.0009623 6 0.03841 57 Protein-protein-interaction for NUP43 www.ncbi.nlm.ni...
Null ppi.EXOSC5 View Gene Set 0.00102 11 0.03841 57 Protein-protein-interaction for EXOSC5 www.ncbi.nlm.ni...
Null ppi.TAF12 View Gene Set 0.0009847 10 0.03841 57 Protein-protein-interaction for TAF12 www.ncbi.nlm.ni...
Null ppi.MED26 View Gene Set 0.001014 22 0.03841 57 Protein-protein-interaction for MED26 www.ncbi.nlm.ni...
Null ppi.LYAR View Gene Set 0.001053 26 0.039 62 Protein-protein-interaction for LYAR www.ncbi.nlm.ni...
Null ppi.PTCD3 View Gene Set 0.001096 6 0.03931 63 Protein-protein-interaction for PTCD3 www.ncbi.nlm.ni...
Null ppi.RNMTL1 View Gene Set 0.001094 8 0.03931 63 Protein-protein-interaction for RNMTL1 www.ncbi.nlm.ni...
Null ppi.MED30 View Gene Set 0.001126 26 0.03931 63 Protein-protein-interaction for MED30 www.ncbi.nlm.ni...
Null ppi.MDC1 View Gene Set 0.00113 20 0.03931 63 Protein-protein-interaction for MDC1 www.ncbi.nlm.ni...
Null ppi.WDR48 View Gene Set 0.001191 52 0.04082 67 Protein-protein-interaction for WDR48 www.ncbi.nlm.ni...
Null ppi.NXF1 View Gene Set 0.001255 9 0.04117 68 Protein-protein-interaction for NXF1 www.ncbi.nlm.ni...
Null ppi.FANCD2 View Gene Set 0.001222 6 0.04117 68 Protein-protein-interaction for FANCD2 www.ncbi.nlm.ni...
Null ppi.SSRP1 View Gene Set 0.001238 15 0.04117 68 Protein-protein-interaction for SSRP1 www.ncbi.nlm.ni...
Null ppi.TP53BP2 View Gene Set 0.001281 8 0.04145 71 Protein-protein-interaction for TP53BP2 www.ncbi.nlm.ni...
Null ppi.HSPA8 View Gene Set 0.001367 21 0.04248 72 Protein-protein-interaction for HSPA8 www.ncbi.nlm.ni...
Null ppi.MCM7 View Gene Set 0.001336 11 0.04248 72 Protein-protein-interaction for MCM7 www.ncbi.nlm.ni...
Null ppi.RPA2 View Gene Set 0.001368 24 0.04248 72 Protein-protein-interaction for RPA2 www.ncbi.nlm.ni...
Null ppi.MED17 View Gene Set 0.001392 15 0.04264 75 Protein-protein-interaction for MED17 www.ncbi.nlm.ni...
Null ppi.C16orf53 View Gene Set 0.001461 9 0.04416 76 Protein-protein-interaction for C16orf53 www.ncbi.nlm.ni...
Null ppi.LSM3 View Gene Set 0.001504 9 0.04471 77 Protein-protein-interaction for LSM3 www.ncbi.nlm.ni...
Null ppi.TP53 View Gene Set 0.001521 168 0.04471 77 Protein-protein-interaction for TP53 www.ncbi.nlm.ni...
Null ppi.MED13 View Gene Set 0.001538 10 0.04471 77 Protein-protein-interaction for MED13 www.ncbi.nlm.ni...
Null ppi.GTF2H2 View Gene Set 0.001607 6 0.04613 80 Protein-protein-interaction for GTF2H2 www.ncbi.nlm.ni...
Null ppi.POLR2C View Gene Set 0.00165 7 0.0468 81 Protein-protein-interaction for POLR2C www.ncbi.nlm.ni...
Null ppi.USP39 View Gene Set 0.00173 15 0.04845 82 Protein-protein-interaction for USP39 www.ncbi.nlm.ni...

Gene Set Collection: ppi.HPRD

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.SFRS12 View Gene Set 2.226e-07 49 0.0005285 1 Protein-protein-interaction for SFRS12 www.ncbi.nlm.ni...
Null ppi.ORC3L View Gene Set 1.014e-05 13 0.01203 2 Protein-protein-interaction for ORC3L www.ncbi.nlm.ni...
Null ppi.EXOSC5 View Gene Set 2.49e-05 18 0.0197 3 Protein-protein-interaction for EXOSC5 www.ncbi.nlm.ni...
Null ppi.SUMO4 View Gene Set 6.692e-05 76 0.02605 4 Protein-protein-interaction for SUMO4 www.ncbi.nlm.ni...
Null ppi.EXOSC4 View Gene Set 6.3e-05 21 0.02605 4 Protein-protein-interaction for EXOSC4 www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 7.683e-05 26 0.02605 4 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.TAF1A View Gene Set 7.677e-05 7 0.02605 4 Protein-protein-interaction for TAF1A www.ncbi.nlm.ni...
Null ppi.XRN1 View Gene Set 8.805e-05 24 0.02613 8 Protein-protein-interaction for XRN1 www.ncbi.nlm.ni...
Null ppi.WRN View Gene Set 0.0001182 17 0.03118 9 Protein-protein-interaction for WRN www.ncbi.nlm.ni...
Null ppi.BRAP View Gene Set 0.0001507 5 0.03578 10 Protein-protein-interaction for BRAP www.ncbi.nlm.ni...
Null ppi.XRN2 View Gene Set 0.0001726 9 0.03725 11 Protein-protein-interaction for XRN2 www.ncbi.nlm.ni...
Null ppi.NUP50 View Gene Set 0.0002063 6 0.0408 12 Protein-protein-interaction for NUP50 www.ncbi.nlm.ni...
Null ppi.POLR2G View Gene Set 0.0002427 7 0.04432 13 Protein-protein-interaction for POLR2G www.ncbi.nlm.ni...

Gene Set Collection: ppi.anyDB

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.155871 View Gene Set 2.677e-19 251 9.622e-16 1 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.SRRM2 View Gene Set 2.11e-12 101 3.791e-09 2 Protein-protein-interaction for SRRM2 www.ncbi.nlm.ni...
Null ppi.MEPCE View Gene Set 9.341e-11 147 1.119e-07 3 Protein-protein-interaction for MEPCE www.ncbi.nlm.ni...
Null ppi.SRRM1 View Gene Set 6.633e-08 66 4.768e-05 4 Protein-protein-interaction for SRRM1 www.ncbi.nlm.ni...
Null ppi.CDT1 View Gene Set 6.059e-08 42 4.768e-05 4 Protein-protein-interaction for CDT1 www.ncbi.nlm.ni...
Null ppi.GPN1 View Gene Set 9.352e-08 27 4.801e-05 6 Protein-protein-interaction for GPN1 www.ncbi.nlm.ni...
Null ppi.SFRS12 View Gene Set 9.123e-08 50 4.801e-05 6 Protein-protein-interaction for SFRS12 www.ncbi.nlm.ni...
Null ppi.72462 View Gene Set 3.199e-07 42 0.0001437 8 Protein-protein-interaction for 72462 www.ncbi.nlm.ni...
Null ppi.ORC3L View Gene Set 5.148e-07 16 0.0002056 9 Protein-protein-interaction for ORC3L www.ncbi.nlm.ni...
Null ppi.PSMD14 View Gene Set 9.014e-07 16 0.0003239 10 Protein-protein-interaction for PSMD14 www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 2.07e-06 52 0.0006764 11 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.USP36 View Gene Set 2.977e-06 17 0.0008916 12 Protein-protein-interaction for USP36 www.ncbi.nlm.ni...
Null ppi.RPAP2 View Gene Set 3.768e-06 43 0.001042 13 Protein-protein-interaction for RPAP2 www.ncbi.nlm.ni...
Null ppi.FANCA View Gene Set 6.554e-06 14 0.001682 14 Protein-protein-interaction for FANCA www.ncbi.nlm.ni...
Null ppi.UCHL5 View Gene Set 7.204e-06 34 0.001726 15 Protein-protein-interaction for UCHL5 www.ncbi.nlm.ni...
Null ppi.WRN View Gene Set 8.485e-06 21 0.001906 16 Protein-protein-interaction for WRN www.ncbi.nlm.ni...
Null ppi.RRP1B View Gene Set 1.198e-05 21 0.002533 17 Protein-protein-interaction for RRP1B www.ncbi.nlm.ni...
Null ppi.CHTF18 View Gene Set 1.584e-05 13 0.003163 18 Protein-protein-interaction for CHTF18 www.ncbi.nlm.ni...
Null ppi.EXOSC5 View Gene Set 1.748e-05 20 0.003307 19 Protein-protein-interaction for EXOSC5 www.ncbi.nlm.ni...
Null ppi.C20orf20 View Gene Set 1.92e-05 16 0.003449 20 Protein-protein-interaction for C20orf20 www.ncbi.nlm.ni...
Null ppi.EIF3F View Gene Set 2.175e-05 25 0.003607 21 Protein-protein-interaction for EIF3F www.ncbi.nlm.ni...
Null ppi.PSMD6 View Gene Set 2.208e-05 23 0.003607 21 Protein-protein-interaction for PSMD6 www.ncbi.nlm.ni...
Null ppi.RNU12-2P View Gene Set 4.129e-05 18 0.005936 23 Protein-protein-interaction for RNU12-2P www.ncbi.nlm.ni...
Null ppi.RNU11 View Gene Set 4.129e-05 18 0.005936 23 Protein-protein-interaction for RNU11 www.ncbi.nlm.ni...
Null ppi.USP14 View Gene Set 3.883e-05 22 0.005936 23 Protein-protein-interaction for USP14 www.ncbi.nlm.ni...
Null ppi.SUMO4 View Gene Set 6.692e-05 76 0.008293 26 Protein-protein-interaction for SUMO4 www.ncbi.nlm.ni...
Null ppi.EXOSC4 View Gene Set 6.3e-05 21 0.008293 26 Protein-protein-interaction for EXOSC4 www.ncbi.nlm.ni...
Null ppi.ING3 View Gene Set 6.359e-05 12 0.008293 26 Protein-protein-interaction for ING3 www.ncbi.nlm.ni...
Null ppi.CDC20 View Gene Set 6.668e-05 5 0.008293 26 Protein-protein-interaction for CDC20 www.ncbi.nlm.ni...
Null ppi.RUVBL2 View Gene Set 7.157e-05 72 0.008574 30 Protein-protein-interaction for RUVBL2 www.ncbi.nlm.ni...
Null ppi.MYSM1 View Gene Set 0.0001012 13 0.01174 31 Protein-protein-interaction for MYSM1 www.ncbi.nlm.ni...
Null ppi.KAT2A View Gene Set 0.0001156 14 0.01222 32 Protein-protein-interaction for KAT2A www.ncbi.nlm.ni...
Null ppi.SSRP1 View Gene Set 0.0001136 21 0.01222 32 Protein-protein-interaction for SSRP1 www.ncbi.nlm.ni...
Null ppi.RPAP3 View Gene Set 0.0001149 30 0.01222 32 Protein-protein-interaction for RPAP3 www.ncbi.nlm.ni...
Null ppi.PRKDC View Gene Set 0.0001332 49 0.01368 35 Protein-protein-interaction for PRKDC www.ncbi.nlm.ni...
Null ppi.SF3B3 View Gene Set 0.0001383 19 0.01381 36 Protein-protein-interaction for SF3B3 www.ncbi.nlm.ni...
Null ppi.NXF1 View Gene Set 0.0001484 17 0.01441 37 Protein-protein-interaction for NXF1 www.ncbi.nlm.ni...
Null ppi.WBP4 View Gene Set 0.0001575 35 0.01458 38 Protein-protein-interaction for WBP4 www.ncbi.nlm.ni...
Null ppi.PAAF1 View Gene Set 0.0001582 20 0.01458 38 Protein-protein-interaction for PAAF1 www.ncbi.nlm.ni...
Null ppi.XRN2 View Gene Set 0.0001726 9 0.01551 40 Protein-protein-interaction for XRN2 www.ncbi.nlm.ni...
Null ppi.PSMD13 View Gene Set 0.0001891 20 0.01658 41 Protein-protein-interaction for PSMD13 www.ncbi.nlm.ni...
Null ppi.SUPT16H View Gene Set 0.0002072 15 0.01732 42 Protein-protein-interaction for SUPT16H www.ncbi.nlm.ni...
Null ppi.DSCC1 View Gene Set 0.0002029 6 0.01732 42 Protein-protein-interaction for DSCC1 www.ncbi.nlm.ni...
Null ppi.TERF2 View Gene Set 0.0002191 10 0.0179 44 Protein-protein-interaction for TERF2 www.ncbi.nlm.ni...
Null ppi.XRN1 View Gene Set 0.0002614 25 0.02088 45 Protein-protein-interaction for XRN1 www.ncbi.nlm.ni...
Null ppi.PTMA View Gene Set 0.0002757 21 0.02154 46 Protein-protein-interaction for PTMA www.ncbi.nlm.ni...
Null ppi.ORC6L View Gene Set 0.0002818 15 0.02155 47 Protein-protein-interaction for ORC6L www.ncbi.nlm.ni...
Null ppi.NUP50 View Gene Set 0.0002908 8 0.02178 48 Protein-protein-interaction for NUP50 www.ncbi.nlm.ni...
Null ppi.THOC4 View Gene Set 0.0003229 5 0.02368 49 Protein-protein-interaction for THOC4 www.ncbi.nlm.ni...
Null ppi.MGMT View Gene Set 0.0003538 28 0.02543 50 Protein-protein-interaction for MGMT www.ncbi.nlm.ni...
Null ppi.XRCC1 View Gene Set 0.0003694 11 0.02603 51 Protein-protein-interaction for XRCC1 www.ncbi.nlm.ni...
Null ppi.HSPH1 View Gene Set 0.0003889 12 0.0262 52 Protein-protein-interaction for HSPH1 www.ncbi.nlm.ni...
Null ppi.FEN1 View Gene Set 0.0003915 11 0.0262 52 Protein-protein-interaction for FEN1 www.ncbi.nlm.ni...
Null ppi.DNAJC7 View Gene Set 0.0003936 8 0.0262 52 Protein-protein-interaction for DNAJC7 www.ncbi.nlm.ni...
Null ppi.PRPF19 View Gene Set 0.0004092 9 0.02674 55 Protein-protein-interaction for PRPF19 www.ncbi.nlm.ni...
Null ppi.EIF3H View Gene Set 0.0004335 16 0.02782 56 Protein-protein-interaction for EIF3H www.ncbi.nlm.ni...
Null ppi.GTF2H2 View Gene Set 0.0004557 7 0.02873 57 Protein-protein-interaction for GTF2H2 www.ncbi.nlm.ni...
Null ppi.TP53 View Gene Set 0.0004649 220 0.02881 58 Protein-protein-interaction for TP53 www.ncbi.nlm.ni...
Null ppi.MLH1 View Gene Set 0.0004919 12 0.02946 59 Protein-protein-interaction for MLH1 www.ncbi.nlm.ni...
Null ppi.MIS12 View Gene Set 0.0004879 9 0.02946 59 Protein-protein-interaction for MIS12 www.ncbi.nlm.ni...
Null ppi.E2F4 View Gene Set 0.0005057 16 0.0298 61 Protein-protein-interaction for E2F4 www.ncbi.nlm.ni...
Null ppi.RAD1 View Gene Set 0.0005294 6 0.03069 62 Protein-protein-interaction for RAD1 www.ncbi.nlm.ni...
Null ppi.SUPT3H View Gene Set 0.0005411 14 0.03087 63 Protein-protein-interaction for SUPT3H www.ncbi.nlm.ni...
Null ppi.TP53BP2 View Gene Set 0.0005535 17 0.03091 64 Protein-protein-interaction for TP53BP2 www.ncbi.nlm.ni...
Null ppi.MED17 View Gene Set 0.0005591 16 0.03091 64 Protein-protein-interaction for MED17 www.ncbi.nlm.ni...
Null ppi.POLD3 View Gene Set 0.0006143 6 0.03259 66 Protein-protein-interaction for POLD3 www.ncbi.nlm.ni...
Null ppi.NAA38 View Gene Set 0.0006217 28 0.03259 66 Protein-protein-interaction for NAA38 www.ncbi.nlm.ni...
Null ppi.RPA2 View Gene Set 0.0006392 25 0.03259 66 Protein-protein-interaction for RPA2 www.ncbi.nlm.ni...
Null ppi.FAM173A View Gene Set 0.0006023 10 0.03259 66 Protein-protein-interaction for FAM173A www.ncbi.nlm.ni...
Null ppi.TERF1 View Gene Set 0.0006439 18 0.03259 66 Protein-protein-interaction for TERF1 www.ncbi.nlm.ni...
Null ppi.BRAP View Gene Set 0.0006341 6 0.03259 66 Protein-protein-interaction for BRAP www.ncbi.nlm.ni...
Null ppi.TPX2 View Gene Set 0.0006733 5 0.03336 72 Protein-protein-interaction for TPX2 www.ncbi.nlm.ni...
Null ppi.GIYD2 View Gene Set 0.0006775 32 0.03336 72 Protein-protein-interaction for GIYD2 www.ncbi.nlm.ni...
Null ppi.TAF10 View Gene Set 0.0007397 29 0.03593 74 Protein-protein-interaction for TAF10 www.ncbi.nlm.ni...
Null ppi.EIF3B View Gene Set 0.0007537 11 0.03612 75 Protein-protein-interaction for EIF3B www.ncbi.nlm.ni...
Null ppi.PRPF40A View Gene Set 0.0007888 96 0.0373 76 Protein-protein-interaction for PRPF40A www.ncbi.nlm.ni...
Null ppi.RPAP1 View Gene Set 0.0008348 24 0.03737 77 Protein-protein-interaction for RPAP1 www.ncbi.nlm.ni...
Null ppi.LSM3 View Gene Set 0.0008195 13 0.03737 77 Protein-protein-interaction for LSM3 www.ncbi.nlm.ni...
Null ppi.CLSPN View Gene Set 0.0008411 18 0.03737 77 Protein-protein-interaction for CLSPN www.ncbi.nlm.ni...
Null ppi.XRCC3 View Gene Set 0.0008141 6 0.03737 77 Protein-protein-interaction for XRCC3 www.ncbi.nlm.ni...
Null ppi.HIST3H2A View Gene Set 0.0008423 6 0.03737 77 Protein-protein-interaction for HIST3H2A www.ncbi.nlm.ni...
Null ppi.KHDRBS2 View Gene Set 0.0009637 48 0.04075 82 Protein-protein-interaction for KHDRBS2 www.ncbi.nlm.ni...
Null ppi.NUP43 View Gene Set 0.0009623 6 0.04075 82 Protein-protein-interaction for NUP43 www.ncbi.nlm.ni...
Null ppi.MCM7 View Gene Set 0.0009305 12 0.04075 82 Protein-protein-interaction for MCM7 www.ncbi.nlm.ni...
Null ppi.OTUB1 View Gene Set 0.0009451 19 0.04075 82 Protein-protein-interaction for OTUB1 www.ncbi.nlm.ni...
Null ppi.FANCD2 View Gene Set 0.001001 7 0.04184 86 Protein-protein-interaction for FANCD2 www.ncbi.nlm.ni...
Null ppi.LYAR View Gene Set 0.001053 26 0.04348 87 Protein-protein-interaction for LYAR www.ncbi.nlm.ni...
Null ppi.SRRT View Gene Set 0.001103 8 0.04421 88 Protein-protein-interaction for SRRT www.ncbi.nlm.ni...
Null ppi.RNMTL1 View Gene Set 0.001094 8 0.04421 88 Protein-protein-interaction for RNMTL1 www.ncbi.nlm.ni...
Null ppi.TP53BP1 View Gene Set 0.001107 17 0.04421 88 Protein-protein-interaction for TP53BP1 www.ncbi.nlm.ni...
Null ppi.LSM2 View Gene Set 0.001136 26 0.0444 91 Protein-protein-interaction for LSM2 www.ncbi.nlm.ni...
Null ppi.MED30 View Gene Set 0.001126 26 0.0444 91 Protein-protein-interaction for MED30 www.ncbi.nlm.ni...
Null ppi.CHAF1A View Gene Set 0.001171 21 0.04525 93 Protein-protein-interaction for CHAF1A www.ncbi.nlm.ni...
Null ppi.WDR48 View Gene Set 0.001191 52 0.04552 94 Protein-protein-interaction for WDR48 www.ncbi.nlm.ni...
Null ppi.SUMO2 View Gene Set 0.001261 55 0.04772 95 Protein-protein-interaction for SUMO2 www.ncbi.nlm.ni...
Null ppi.MAP3K14 View Gene Set 0.001298 36 0.04858 96 Protein-protein-interaction for MAP3K14 www.ncbi.nlm.ni...

Gene Set Collection: pathwayCommons.cell-map

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null TNF alpha/NF-kB View Gene Set 0.002253 170 0.02253 1 CELL_MAP - TNF alpha/NF-kB gene set www.pathwaycomm...

Gene Set Collection: pathwayCommons.humancyc

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null pyrimidine deoxyribonucleotides de novo biosynthesis View Gene Set 0.0001422 14 0.03697 1 HUMANCYC - pyrimidine deoxyribonucleotides de novo biosynthesis gene set www.pathwaycomm...

Gene Set Collection: pathwayCommons.nci-nature

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null Aurora B signaling View Gene Set 1.794e-08 41 3.336e-06 1 NCI_NATURE - Aurora B signaling gene set www.pathwaycomm...
Null Validated targets of C-MYC transcriptional activation View Gene Set 6.458e-07 80 6.006e-05 2 NCI_NATURE - Validated targets of C-MYC transcriptional activation gene set www.pathwaycomm...
Null Signaling by Aurora kinases View Gene Set 3.86e-06 98 0.0002393 3 NCI_NATURE - Signaling by Aurora kinases gene set www.pathwaycomm...
Null PLK1 signaling events View Gene Set 3.441e-05 104 0.0016 4 NCI_NATURE - PLK1 signaling events gene set www.pathwaycomm...
Null Polo-like kinase signaling events in the cell cycle View Gene Set 8.927e-05 109 0.003321 5 NCI_NATURE - Polo-like kinase signaling events in the cell cycle gene set www.pathwaycomm...
Null C-MYC pathway View Gene Set 0.0002632 149 0.008158 6 NCI_NATURE - C-MYC pathway gene set www.pathwaycomm...

Gene Set Collection: pathwayCommons.reactome

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null Cell Cycle Mitotic View Gene Set 1.175e-41 312 1.312e-38 1 REACTOME - Cell Cycle Mitotic gene set www.pathwaycomm... Mitotic&format=...
Null DNA Replication View Gene Set 1.599e-30 200 8.928e-28 2 REACTOME - DNA Replication gene set www.pathwaycomm...
Null Mitotic M-M/G1 phases View Gene Set 1.401e-28 180 5.215e-26 3 REACTOME - Mitotic M-M/G1 phases gene set www.pathwaycomm...
Null M Phase View Gene Set 3.979e-23 90 1.111e-20 4 REACTOME - M Phase gene set www.pathwaycomm...
Null Gene Expression View Gene Set 1.445e-21 381 2.811e-19 5 REACTOME - Gene Expression gene set www.pathwaycomm...
Null Mitotic Prometaphase View Gene Set 1.51e-21 86 2.811e-19 5 REACTOME - Mitotic Prometaphase gene set www.pathwaycomm...
Null Processing of Capped Intron-Containing Pre-mRNA View Gene Set 6.853e-21 138 1.094e-18 7 REACTOME - Processing of Capped Intron-Containing Pre-mRNA gene set www.pathwaycomm...
Null mRNA Processing View Gene Set 1.136e-20 158 1.41e-18 8 REACTOME - mRNA Processing gene set www.pathwaycomm...
Null Formation and Maturation of mRNA Transcript View Gene Set 1.116e-20 185 1.41e-18 8 REACTOME - Formation and Maturation of mRNA Transcript gene set www.pathwaycomm...
Null Metabolism of RNA View Gene Set 1.868e-17 174 2.086e-15 10 REACTOME - Metabolism of RNA gene set www.pathwaycomm...
Null Cell Cycle Checkpoints View Gene Set 1.09e-16 124 1.107e-14 11 REACTOME - Cell Cycle Checkpoints gene set www.pathwaycomm...
Null mRNA Splicing - Major Pathway View Gene Set 8.165e-16 107 7.016e-14 12 REACTOME - mRNA Splicing - Major Pathway gene set www.pathwaycomm...
Null mRNA Splicing View Gene Set 8.165e-16 107 7.016e-14 12 REACTOME - mRNA Splicing gene set www.pathwaycomm...
Null Regulation of mitotic cell cycle View Gene Set 2.261e-12 95 1.684e-10 14 REACTOME - Regulation of mitotic cell cycle gene set www.pathwaycomm...
Null APC/C-mediated degradation of cell cycle proteins View Gene Set 2.261e-12 95 1.684e-10 14 REACTOME - APC/C-mediated degradation of cell cycle proteins gene set www.pathwaycomm...
Null G1/S Transition View Gene Set 5.179e-12 104 3.615e-10 16 REACTOME - G1/S Transition gene set www.pathwaycomm...
Null G2/M Transition View Gene Set 5.921e-12 96 3.89e-10 17 REACTOME - G2/M Transition gene set www.pathwaycomm...
Null Mitotic G2-G2/M phases View Gene Set 7.382e-12 98 4.581e-10 18 REACTOME - Mitotic G2-G2/M phases gene set www.pathwaycomm...
Null Metabolism of mRNA View Gene Set 1.229e-11 125 7.227e-10 19 REACTOME - Metabolism of mRNA gene set www.pathwaycomm...
Null Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins View Gene Set 2.229e-11 86 1.245e-09 20 REACTOME - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins gene set www.pathwaycomm...
Null Mitotic G1-G1/S phases View Gene Set 2.443e-11 113 1.299e-09 21 REACTOME - Mitotic G1-G1/S phases gene set www.pathwaycomm...
Null Centrosome maturation View Gene Set 2.988e-11 73 1.451e-09 22 REACTOME - Centrosome maturation gene set www.pathwaycomm...
Null Recruitment of mitotic centrosome proteins and complexes View Gene Set 2.988e-11 72 1.451e-09 22 REACTOME - Recruitment of mitotic centrosome proteins and complexes gene set www.pathwaycomm...
Null HIV Infection View Gene Set 7.747e-11 194 3.606e-09 24 REACTOME - HIV Infection gene set www.pathwaycomm...
Null G2/M Checkpoints View Gene Set 9.404e-11 43 4.04e-09 25 REACTOME - G2/M Checkpoints gene set www.pathwaycomm...
Null Regulation of APC/C activators between G1/S and early anaphase View Gene Set 9.221e-11 88 4.04e-09 25 REACTOME - Regulation of APC/C activators between G1/S and early anaphase gene set www.pathwaycomm...
Null Transport of Mature Transcript to Cytoplasm View Gene Set 1.341e-10 55 5.548e-09 27 REACTOME - Transport of Mature Transcript to Cytoplasm gene set www.pathwaycomm...
Null S Phase View Gene Set 3.178e-10 113 1.268e-08 28 REACTOME - S Phase gene set www.pathwaycomm...
Null APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 View Gene Set 3.316e-10 77 1.277e-08 29 REACTOME - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 gene set www.pathwaycomm...
Null APC/C:Cdc20 mediated degradation of mitotic proteins View Gene Set 3.748e-10 77 1.395e-08 30 REACTOME - APC/C:Cdc20 mediated degradation of mitotic proteins gene set www.pathwaycomm...
Null Activation of ATR in response to replication stress View Gene Set 7.61e-10 37 2.742e-08 31 REACTOME - Activation of ATR in response to replication stress gene set www.pathwaycomm...
Null Synthesis of DNA View Gene Set 9.143e-10 102 3.191e-08 32 REACTOME - Synthesis of DNA gene set www.pathwaycomm...
Null Transport of Mature mRNA derived from an Intron-Containing Transcript View Gene Set 1.487e-09 51 5.032e-08 33 REACTOME - Transport of Mature mRNA derived from an Intron-Containing Transcript gene set www.pathwaycomm...
Null Autodegradation of Cdh1 by Cdh1:APC/C View Gene Set 2.368e-09 67 7.779e-08 34 REACTOME - Autodegradation of Cdh1 by Cdh1:APC/C gene set www.pathwaycomm...
Null Cdc20:Phospho-APC/C mediated degradation of Cyclin A View Gene Set 2.504e-09 75 7.99e-08 35 REACTOME - Cdc20:Phospho-APC/C mediated degradation of Cyclin A gene set www.pathwaycomm...
Null DNA Replication Pre-Initiation View Gene Set 3.469e-09 90 1.047e-07 36 REACTOME - DNA Replication Pre-Initiation gene set www.pathwaycomm...
Null M/G1 Transition View Gene Set 3.469e-09 90 1.047e-07 36 REACTOME - M/G1 Transition gene set www.pathwaycomm...
Null Assembly of the pre-replicative complex View Gene Set 4.525e-09 75 1.33e-07 38 REACTOME - Assembly of the pre-replicative complex gene set www.pathwaycomm...
Null Deadenylation-dependent mRNA decay View Gene Set 9.702e-09 46 2.779e-07 39 REACTOME - Deadenylation-dependent mRNA decay gene set www.pathwaycomm...
Null DNA Repair View Gene Set 1.207e-08 108 3.37e-07 40 REACTOME - DNA Repair gene set www.pathwaycomm...
Null Regulation of DNA replication View Gene Set 1.564e-08 81 4.262e-07 41 REACTOME - Regulation of DNA replication gene set www.pathwaycomm...
Null Host Interactions of HIV factors View Gene Set 1.736e-08 132 4.618e-07 42 REACTOME - Host Interactions of HIV factors gene set www.pathwaycomm...
Null Removal of licensing factors from origins View Gene Set 2.322e-08 78 6.032e-07 43 REACTOME - Removal of licensing factors from origins gene set www.pathwaycomm...
Null APC/C:Cdc20 mediated degradation of Securin View Gene Set 2.538e-08 72 6.442e-07 44 REACTOME - APC/C:Cdc20 mediated degradation of Securin gene set www.pathwaycomm...
Null CDT1 association with the CDC6:ORC:origin complex View Gene Set 2.681e-08 66 6.655e-07 45 REACTOME - CDT1 association with the CDC6:ORC:origin complex gene set www.pathwaycomm...
Null Interactions of Rev with host cellular proteins View Gene Set 3.711e-08 33 9.01e-07 46 REACTOME - Interactions of Rev with host cellular proteins gene set www.pathwaycomm...
Null RNA Polymerase II Transcription View Gene Set 8.867e-08 101 2.105e-06 47 REACTOME - RNA Polymerase II Transcription gene set www.pathwaycomm...
Null Regulation of mRNA Stability by Proteins that Bind AU-rich Elements View Gene Set 9.424e-08 95 2.105e-06 47 REACTOME - Regulation of mRNA Stability by Proteins that Bind AU-rich Elements gene set www.pathwaycomm...
Null snRNP Assembly View Gene Set 9.384e-08 50 2.105e-06 47 REACTOME - snRNP Assembly gene set www.pathwaycomm...
Null Metabolism of non-coding RNA View Gene Set 9.384e-08 50 2.105e-06 47 REACTOME - Metabolism of non-coding RNA gene set www.pathwaycomm...
Null Rev-mediated nuclear export of HIV-1 RNA View Gene Set 1.069e-07 32 2.341e-06 51 REACTOME - Rev-mediated nuclear export of HIV-1 RNA gene set www.pathwaycomm...
Null Switching of origins to a post-replicative state View Gene Set 1.118e-07 76 2.357e-06 52 REACTOME - Switching of origins to a post-replicative state gene set www.pathwaycomm...
Null Orc1 removal from chromatin View Gene Set 1.118e-07 76 2.357e-06 52 REACTOME - Orc1 removal from chromatin gene set www.pathwaycomm...
Null Loss of proteins required for interphase microtubule organization from the centrosome View Gene Set 1.387e-07 62 2.817e-06 54 REACTOME - Loss of proteins required for interphase microtubule organization from the centrosome gene set www.pathwaycomm...
Null Loss of Nlp from mitotic centrosomes View Gene Set 1.387e-07 62 2.817e-06 54 REACTOME - Loss of Nlp from mitotic centrosomes gene set www.pathwaycomm...
Null Late Phase of HIV Life Cycle View Gene Set 1.705e-07 92 3.401e-06 56 REACTOME - Late Phase of HIV Life Cycle gene set www.pathwaycomm...
Null SCF(Skp2)-mediated degradation of p27/p21 View Gene Set 1.887e-07 52 3.699e-06 57 REACTOME - SCF(Skp2)-mediated degradation of p27/p21 gene set www.pathwaycomm...
Null Transport of Mature mRNAs Derived from Intronless Transcripts View Gene Set 2.156e-07 36 4.151e-06 58 REACTOME - Transport of Mature mRNAs Derived from Intronless Transcripts gene set www.pathwaycomm...
Null HIV Life Cycle View Gene Set 2.334e-07 103 4.419e-06 59 REACTOME - HIV Life Cycle gene set www.pathwaycomm...
Null Transport of Mature mRNA Derived from an Intronless Transcript View Gene Set 3.52e-07 35 6.414e-06 60 REACTOME - Transport of Mature mRNA Derived from an Intronless Transcript gene set www.pathwaycomm...
Null Post-Elongation Processing of the Transcript View Gene Set 3.618e-07 43 6.414e-06 60 REACTOME - Post-Elongation Processing of the Transcript gene set www.pathwaycomm...
Null Cleavage of Growing Transcript in the Termination Region View Gene Set 3.618e-07 43 6.414e-06 60 REACTOME - Cleavage of Growing Transcript in the Termination Region gene set www.pathwaycomm...
Null RNA Polymerase II Transcription Termination View Gene Set 3.618e-07 43 6.414e-06 60 REACTOME - RNA Polymerase II Transcription Termination gene set www.pathwaycomm...
Null Protein folding View Gene Set 3.834e-07 29 6.691e-06 64 REACTOME - Protein folding gene set www.pathwaycomm...
Null Nuclear import of Rev protein View Gene Set 3.981e-07 30 6.738e-06 65 REACTOME - Nuclear import of Rev protein gene set www.pathwaycomm...
Null G2/M DNA damage checkpoint View Gene Set 3.932e-07 29 6.738e-06 65 REACTOME - G2/M DNA damage checkpoint gene set www.pathwaycomm...
Null Export of Viral Ribonucleoproteins from Nucleus View Gene Set 6.793e-07 31 1.1e-05 67 REACTOME - Export of Viral Ribonucleoproteins from Nucleus gene set www.pathwaycomm...
Null Recruitment of NuMA to mitotic centrosomes View Gene Set 6.766e-07 14 1.1e-05 67 REACTOME - Recruitment of NuMA to mitotic centrosomes gene set www.pathwaycomm...
Null SCF-beta-TrCP mediated degradation of Emi1 View Gene Set 6.599e-07 60 1.1e-05 67 REACTOME - SCF-beta-TrCP mediated degradation of Emi1 gene set www.pathwaycomm...
Null Post-Elongation Processing of Intron-Containing pre-mRNA View Gene Set 1.014e-06 34 1.596e-05 70 REACTOME - Post-Elongation Processing of Intron-Containing pre-mRNA gene set www.pathwaycomm...
Null mRNA 3'-end processing View Gene Set 1.014e-06 34 1.596e-05 70 REACTOME - mRNA 3'-end processing gene set www.pathwaycomm...
Null Cyclin A:Cdk2-associated events at S phase entry View Gene Set 1.117e-06 62 1.734e-05 72 REACTOME - Cyclin A:Cdk2-associated events at S phase entry gene set www.pathwaycomm...
Null Transport of the SLBP Dependant Mature mRNA View Gene Set 1.5e-06 33 2.294e-05 73 REACTOME - Transport of the SLBP Dependant Mature mRNA gene set www.pathwaycomm...
Null NEP/NS2 Interacts with the Cellular Export Machinery View Gene Set 1.548e-06 29 2.337e-05 74 REACTOME - NEP/NS2 Interacts with the Cellular Export Machinery gene set www.pathwaycomm...
Null Chromosome Maintenance View Gene Set 2.016e-06 69 2.964e-05 75 REACTOME - Chromosome Maintenance gene set www.pathwaycomm...
Null p53-Independent G1/S DNA damage checkpoint View Gene Set 2.067e-06 62 2.964e-05 75 REACTOME - p53-Independent G1/S DNA damage checkpoint gene set www.pathwaycomm...
Null p53-Independent DNA Damage Response View Gene Set 2.067e-06 62 2.964e-05 75 REACTOME - p53-Independent DNA Damage Response gene set www.pathwaycomm...
Null Cyclin E associated events during G1/S transition View Gene Set 2.07e-06 64 2.964e-05 75 REACTOME - Cyclin E associated events during G1/S transition gene set www.pathwaycomm...
Null Transcription View Gene Set 2.128e-06 178 3.009e-05 79 REACTOME - Transcription gene set www.pathwaycomm...
Null Transport of the SLBP independent Mature mRNA View Gene Set 2.446e-06 32 3.415e-05 80 REACTOME - Transport of the SLBP independent Mature mRNA gene set www.pathwaycomm...
Null Destabilization of mRNA by AUF1 (hnRNP D0) View Gene Set 2.507e-06 63 3.457e-05 81 REACTOME - Destabilization of mRNA by AUF1 (hnRNP D0) gene set www.pathwaycomm...
Null Transport of Ribonucleoproteins into the Host Nucleus View Gene Set 3.137e-06 29 4.274e-05 82 REACTOME - Transport of Ribonucleoproteins into the Host Nucleus gene set www.pathwaycomm...
Null Regulation of activated PAK-2p34 by proteasome mediated degradation View Gene Set 3.194e-06 57 4.298e-05 83 REACTOME - Regulation of activated PAK-2p34 by proteasome mediated degradation gene set www.pathwaycomm...
Null Ubiquitin Mediated Degradation of Phosphorylated Cdc25A View Gene Set 4.763e-06 61 6.334e-05 84 REACTOME - Ubiquitin Mediated Degradation of Phosphorylated Cdc25A gene set www.pathwaycomm...
Null Vpu mediated degradation of CD4 View Gene Set 4.93e-06 57 6.478e-05 85 REACTOME - Vpu mediated degradation of CD4 gene set www.pathwaycomm...
Null Degradation of beta-catenin by the destruction complex View Gene Set 5.276e-06 56 6.774e-05 86 REACTOME - Degradation of beta-catenin by the destruction complex gene set www.pathwaycomm...
Null Signaling by Wnt View Gene Set 5.276e-06 56 6.774e-05 86 REACTOME - Signaling by Wnt gene set www.pathwaycomm...
Null Ubiquitin-dependent degradation of Cyclin D1 View Gene Set 5.45e-06 59 6.784e-05 88 REACTOME - Ubiquitin-dependent degradation of Cyclin D1 gene set www.pathwaycomm...
Null Ubiquitin-dependent degradation of Cyclin D View Gene Set 5.45e-06 59 6.784e-05 88 REACTOME - Ubiquitin-dependent degradation of Cyclin D gene set www.pathwaycomm...
Null APC-Cdc20 mediated degradation of Nek2A View Gene Set 5.466e-06 23 6.784e-05 88 REACTOME - APC-Cdc20 mediated degradation of Nek2A gene set www.pathwaycomm...
Null CDK-mediated phosphorylation and removal of Cdc6 View Gene Set 5.885e-06 58 7.224e-05 91 REACTOME - CDK-mediated phosphorylation and removal of Cdc6 gene set www.pathwaycomm...
Null Mitochondrial tRNA aminoacylation View Gene Set 8.785e-06 21 0.0001067 92 REACTOME - Mitochondrial tRNA aminoacylation gene set www.pathwaycomm...
Null Phosphorylation of the APC/C View Gene Set 1.062e-05 26 0.0001276 93 REACTOME - Phosphorylation of the APC/C gene set www.pathwaycomm...
Null Autodegradation of the E3 ubiquitin ligase COP1 View Gene Set 1.531e-05 60 0.0001805 94 REACTOME - Autodegradation of the E3 ubiquitin ligase COP1 gene set www.pathwaycomm...
Null APC/C:Cdc20 mediated degradation of Cyclin B View Gene Set 1.535e-05 22 0.0001805 94 REACTOME - APC/C:Cdc20 mediated degradation of Cyclin B gene set www.pathwaycomm...
Null Interactions of Vpr with host cellular proteins View Gene Set 1.761e-05 34 0.0002049 96 REACTOME - Interactions of Vpr with host cellular proteins gene set www.pathwaycomm...
Null Regulation of ornithine decarboxylase (ODC) View Gene Set 1.832e-05 62 0.0002088 97 REACTOME - Regulation of ornithine decarboxylase (ODC) gene set www.pathwaycomm...
Null Vif-mediated degradation of APOBEC3G View Gene Set 1.829e-05 61 0.0002088 97 REACTOME - Vif-mediated degradation of APOBEC3G gene set www.pathwaycomm...
Null G1/S DNA Damage Checkpoints View Gene Set 2.467e-05 68 0.0002783 99 REACTOME - G1/S DNA Damage Checkpoints gene set www.pathwaycomm...
Null Stabilization of p53 View Gene Set 3.45e-05 61 0.0003854 100 REACTOME - Stabilization of p53 gene set www.pathwaycomm...
Null tRNA Aminoacylation View Gene Set 3.49e-05 42 0.000386 101 REACTOME - tRNA Aminoacylation gene set www.pathwaycomm...
Null Mitotic Spindle Checkpoint View Gene Set 3.63e-05 19 0.0003946 102 REACTOME - Mitotic Spindle Checkpoint gene set www.pathwaycomm...
Null Regulation of Glucokinase by Glucokinase Regulatory Protein View Gene Set 3.639e-05 29 0.0003946 102 REACTOME - Regulation of Glucokinase by Glucokinase Regulatory Protein gene set www.pathwaycomm...
Null Fanconi Anemia pathway View Gene Set 3.73e-05 22 0.0004006 104 REACTOME - Fanconi Anemia pathway gene set www.pathwaycomm...
Null Pyrimidine biosynthesis View Gene Set 4.158e-05 6 0.0004424 105 REACTOME - Pyrimidine biosynthesis gene set www.pathwaycomm...
Null Kinesins View Gene Set 4.308e-05 22 0.000454 106 REACTOME - Kinesins gene set www.pathwaycomm...
Null Vpr-mediated nuclear import of PICs View Gene Set 5.541e-05 31 0.0005785 107 REACTOME - Vpr-mediated nuclear import of PICs gene set www.pathwaycomm...
Null G1/S-Specific Transcription View Gene Set 6.373e-05 16 0.0006592 108 REACTOME - G1/S-Specific Transcription gene set www.pathwaycomm...
Null Metabolism of nucleotides View Gene Set 6.57e-05 66 0.0006733 109 REACTOME - Metabolism of nucleotides gene set www.pathwaycomm...
Null Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components View Gene Set 7.05e-05 18 0.0007095 110 REACTOME - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components gene set www.pathwaycomm...
Null Inactivation of APC/C via direct inhibition of the APC/C complex View Gene Set 7.05e-05 18 0.0007095 110 REACTOME - Inactivation of APC/C via direct inhibition of the APC/C complex gene set www.pathwaycomm...
Null Metabolism of folate and pterines View Gene Set 9.199e-05 8 0.0009175 112 REACTOME - Metabolism of folate and pterines gene set www.pathwaycomm...
Null Transcription-coupled NER (TC-NER) View Gene Set 9.674e-05 45 0.0009563 113 REACTOME - Transcription-coupled NER (TC-NER) gene set www.pathwaycomm...
Null mRNA Decay by 3' to 5' Exoribonuclease View Gene Set 0.0001049 11 0.001028 114 REACTOME - mRNA Decay by 3' to 5' Exoribonuclease gene set www.pathwaycomm...
Null Extension of Telomeres View Gene Set 0.0001111 28 0.001079 115 REACTOME - Extension of Telomeres gene set www.pathwaycomm...
Null p53-Dependent G1/S DNA damage checkpoint View Gene Set 0.0001178 64 0.001115 116 REACTOME - p53-Dependent G1/S DNA damage checkpoint gene set www.pathwaycomm...
Null p53-Dependent G1 DNA Damage Response View Gene Set 0.0001178 64 0.001115 116 REACTOME - p53-Dependent G1 DNA Damage Response gene set www.pathwaycomm...
Null Glucose transport View Gene Set 0.0001177 38 0.001115 116 REACTOME - Glucose transport gene set www.pathwaycomm...
Null DNA strand elongation View Gene Set 0.0001257 31 0.00118 119 REACTOME - DNA strand elongation gene set www.pathwaycomm...
Null Regulation of Apoptosis View Gene Set 0.0001279 66 0.00118 120 REACTOME - Regulation of Apoptosis gene set www.pathwaycomm...
Null Influenza Infection View Gene Set 0.0001271 143 0.00118 120 REACTOME - Influenza Infection gene set www.pathwaycomm...
Null Nucleotide Excision Repair View Gene Set 0.0001308 51 0.001197 122 REACTOME - Nucleotide Excision Repair gene set www.pathwaycomm...
Null mRNA Splicing - Minor Pathway View Gene Set 0.0001571 42 0.001427 123 REACTOME - mRNA Splicing - Minor Pathway gene set www.pathwaycomm...
Null Post-chaperonin tubulin folding pathway View Gene Set 0.0001643 13 0.00148 124 REACTOME - Post-chaperonin tubulin folding pathway gene set www.pathwaycomm...
Null Olfactory Signaling Pathway View Gene Set 0.0002297 370 0.002052 125 REACTOME - Olfactory Signaling Pathway gene set www.pathwaycomm...
Null E2F mediated regulation of DNA replication View Gene Set 0.0002333 28 0.002068 126 REACTOME - E2F mediated regulation of DNA replication gene set www.pathwaycomm...
Null Hexose transport View Gene Set 0.000294 40 0.002545 127 REACTOME - Hexose transport gene set www.pathwaycomm...
Null Activation of the pre-replicative complex View Gene Set 0.0002939 30 0.002545 127 REACTOME - Activation of the pre-replicative complex gene set www.pathwaycomm...
Null Deadenylation of mRNA View Gene Set 0.0002936 22 0.002545 127 REACTOME - Deadenylation of mRNA gene set www.pathwaycomm...
Null Citric acid cycle (TCA cycle) View Gene Set 0.0003003 19 0.00258 130 REACTOME - Citric acid cycle (TCA cycle) gene set www.pathwaycomm...
Null Phosphorylation of Emi1 View Gene Set 0.0003028 12 0.002582 131 REACTOME - Phosphorylation of Emi1 gene set www.pathwaycomm...
Null Chaperonin-mediated protein folding View Gene Set 0.0003057 16 0.002587 132 REACTOME - Chaperonin-mediated protein folding gene set www.pathwaycomm...
Null Folding of actin by CCT/TriC View Gene Set 0.0003366 9 0.002827 133 REACTOME - Folding of actin by CCT/TriC gene set www.pathwaycomm...
Null Telomere Extension By Telomerase View Gene Set 0.0003622 6 0.00302 134 REACTOME - Telomere Extension By Telomerase gene set www.pathwaycomm...
Null Association of TriC/CCT with target proteins during biosynthesis View Gene Set 0.0003747 9 0.0031 135 REACTOME - Association of TriC/CCT with target proteins during biosynthesis gene set www.pathwaycomm...
Null Association of licensing factors with the pre-replicative complex View Gene Set 0.00053 15 0.004353 136 REACTOME - Association of licensing factors with the pre-replicative complex gene set www.pathwaycomm...
Null Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase View Gene Set 0.0005775 16 0.004708 137 REACTOME - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase gene set www.pathwaycomm...
Null Influenza Life Cycle View Gene Set 0.0007047 138 0.005704 138 REACTOME - Influenza Life Cycle gene set www.pathwaycomm...
Null Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding View Gene Set 0.0007116 15 0.005718 139 REACTOME - Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding gene set www.pathwaycomm...
Null E2F-enabled inhibition of pre-replication complex formation View Gene Set 0.0009441 10 0.007533 140 REACTOME - E2F-enabled inhibition of pre-replication complex formation gene set www.pathwaycomm...
Null Formation of tubulin folding intermediates by CCT/TriC View Gene Set 0.0009755 8 0.007728 141 REACTOME - Formation of tubulin folding intermediates by CCT/TriC gene set www.pathwaycomm...
Null Destabilization of mRNA by KSRP View Gene Set 0.001137 18 0.008943 142 REACTOME - Destabilization of mRNA by KSRP gene set www.pathwaycomm...
Null Gap-filling DNA repair synthesis and ligation in TC-NER View Gene Set 0.001255 16 0.009738 143 REACTOME - Gap-filling DNA repair synthesis and ligation in TC-NER gene set www.pathwaycomm...
Null Gap-filling DNA repair synthesis and ligation in GG-NER View Gene Set 0.001255 16 0.009738 143 REACTOME - Gap-filling DNA repair synthesis and ligation in GG-NER gene set www.pathwaycomm...
Null Unwinding of DNA View Gene Set 0.001378 11 0.01062 145 REACTOME - Unwinding of DNA gene set www.pathwaycomm...
Null Post-Elongation Processing of Intronless pre-mRNA View Gene Set 0.001433 23 0.01089 146 REACTOME - Post-Elongation Processing of Intronless pre-mRNA gene set www.pathwaycomm...
Null Processing of Capped Intronless Pre-mRNA View Gene Set 0.001433 23 0.01089 146 REACTOME - Processing of Capped Intronless Pre-mRNA gene set www.pathwaycomm...
Null Formation of the HIV-1 Early Elongation Complex View Gene Set 0.001455 32 0.01091 148 REACTOME - Formation of the HIV-1 Early Elongation Complex gene set www.pathwaycomm...
Null Formation of the Early Elongation Complex View Gene Set 0.001455 32 0.01091 148 REACTOME - Formation of the Early Elongation Complex gene set www.pathwaycomm...
Null Homologous Recombination Repair View Gene Set 0.001564 22 0.01157 150 REACTOME - Homologous Recombination Repair gene set www.pathwaycomm...
Null Homologous recombination repair of replication-independent double-strand breaks View Gene Set 0.001564 22 0.01157 150 REACTOME - Homologous recombination repair of replication-independent double-strand breaks gene set www.pathwaycomm...
Null Activation of DNA fragmentation factor View Gene Set 0.001599 8 0.01167 152 REACTOME - Activation of DNA fragmentation factor gene set www.pathwaycomm...
Null Apoptosis induced DNA fragmentation View Gene Set 0.001599 8 0.01167 152 REACTOME - Apoptosis induced DNA fragmentation gene set www.pathwaycomm...
Null Metabolism of carbohydrates View Gene Set 0.001702 93 0.01234 154 REACTOME - Metabolism of carbohydrates gene set www.pathwaycomm...
Null Apoptosis View Gene Set 0.00173 148 0.01247 155 REACTOME - Apoptosis gene set www.pathwaycomm...
Null Prefoldin mediated transfer of substrate to CCT/TriC View Gene Set 0.001767 14 0.01265 156 REACTOME - Prefoldin mediated transfer of substrate to CCT/TriC gene set www.pathwaycomm...
Null CDC6 association with the ORC:origin complex View Gene Set 0.001847 11 0.01314 157 REACTOME - CDC6 association with the ORC:origin complex gene set www.pathwaycomm...
Null RNA Polymerase II Pre-transcription Events View Gene Set 0.0019 58 0.01335 158 REACTOME - RNA Polymerase II Pre-transcription Events gene set www.pathwaycomm...
Null Purine ribonucleoside monophosphate biosynthesis View Gene Set 0.001889 7 0.01335 158 REACTOME - Purine ribonucleoside monophosphate biosynthesis gene set www.pathwaycomm...
Null Pentose phosphate pathway (hexose monophosphate shunt) View Gene Set 0.002027 6 0.01415 160 REACTOME - Pentose phosphate pathway (hexose monophosphate shunt) gene set www.pathwaycomm...
Null Pyruvate metabolism and Citric Acid (TCA) cycle View Gene Set 0.002066 31 0.01424 161 REACTOME - Pyruvate metabolism and Citric Acid (TCA) cycle gene set www.pathwaycomm...
Null S6K1-mediated signalling View Gene Set 0.002054 9 0.01424 161 REACTOME - S6K1-mediated signalling gene set www.pathwaycomm...
Null Formation of HIV-1 elongation complex containing HIV-1 Tat View Gene Set 0.002225 41 0.0147 163 REACTOME - Formation of HIV-1 elongation complex containing HIV-1 Tat gene set www.pathwaycomm...
Null Tat-mediated elongation of the HIV-1 transcript View Gene Set 0.002225 41 0.0147 163 REACTOME - Tat-mediated elongation of the HIV-1 transcript gene set www.pathwaycomm...
Null HIV-1 Transcription Elongation View Gene Set 0.002225 41 0.0147 163 REACTOME - HIV-1 Transcription Elongation gene set www.pathwaycomm...
Null Formation of HIV-1 elongation complex in the absence of HIV-1 Tat View Gene Set 0.002223 42 0.0147 163 REACTOME - Formation of HIV-1 elongation complex in the absence of HIV-1 Tat gene set www.pathwaycomm...
Null Formation of RNA Pol II elongation complex View Gene Set 0.002223 42 0.0147 163 REACTOME - Formation of RNA Pol II elongation complex gene set www.pathwaycomm...
Null RNA Polymerase II Transcription Elongation View Gene Set 0.002223 42 0.0147 163 REACTOME - RNA Polymerase II Transcription Elongation gene set www.pathwaycomm...
Null Ribosomal scanning and start codon recognition View Gene Set 0.002149 56 0.0147 163 REACTOME - Ribosomal scanning and start codon recognition gene set www.pathwaycomm...
Null Cyclin B2 mediated events View Gene Set 0.002279 5 0.01498 170 REACTOME - Cyclin B2 mediated events gene set www.pathwaycomm...
Null Mitotic Telophase /Cytokinesis View Gene Set 0.002316 10 0.01513 171 REACTOME - Mitotic Telophase /Cytokinesis gene set www.pathwaycomm...
Null Global Genomic NER (GG-NER) View Gene Set 0.002879 35 0.01869 172 REACTOME - Global Genomic NER (GG-NER) gene set www.pathwaycomm...
Null Removal of DNA patch containing abasic residue View Gene Set 0.003183 17 0.02043 173 REACTOME - Removal of DNA patch containing abasic residue gene set www.pathwaycomm...
Null Resolution of AP sites via the multiple-nucleotide patch replacement pathway View Gene Set 0.003183 17 0.02043 173 REACTOME - Resolution of AP sites via the multiple-nucleotide patch replacement pathway gene set www.pathwaycomm...
Null Host Interactions with Influenza Factors View Gene Set 0.003244 5 0.0207 175 REACTOME - Host Interactions with Influenza Factors gene set www.pathwaycomm...
Null mTORC1-mediated signalling View Gene Set 0.003433 11 0.02179 176 REACTOME - mTORC1-mediated signalling gene set www.pathwaycomm...
Null Regulation of the Fanconi anemia pathway View Gene Set 0.003629 8 0.0229 177 REACTOME - Regulation of the Fanconi anemia pathway gene set www.pathwaycomm...
Null Repair synthesis for gap-filling by DNA polymerase in TC-NER View Gene Set 0.003837 15 0.02394 178 REACTOME - Repair synthesis for gap-filling by DNA polymerase in TC-NER gene set www.pathwaycomm...
Null Repair synthesis of patch ~27-30 bases long by DNA polymerase View Gene Set 0.003837 15 0.02394 178 REACTOME - Repair synthesis of patch ~27-30 bases long by DNA polymerase gene set www.pathwaycomm...
Null mRNA Decay by 5' to 3' Exoribonuclease View Gene Set 0.004124 13 0.02559 180 REACTOME - mRNA Decay by 5' to 3' Exoribonuclease gene set www.pathwaycomm...
Null Telomere Maintenance View Gene Set 0.004306 49 0.02587 181 REACTOME - Telomere Maintenance gene set www.pathwaycomm...
Null Deposition of New CENPA-containing Nucleosomes at the Centromere View Gene Set 0.004308 35 0.02587 181 REACTOME - Deposition of New CENPA-containing Nucleosomes at the Centromere gene set www.pathwaycomm...
Null Nucleosome assembly View Gene Set 0.004308 35 0.02587 181 REACTOME - Nucleosome assembly gene set www.pathwaycomm...
Null Base Excision Repair View Gene Set 0.004302 19 0.02587 181 REACTOME - Base Excision Repair gene set www.pathwaycomm...
Null Resolution of Abasic Sites (AP sites) View Gene Set 0.004302 19 0.02587 181 REACTOME - Resolution of Abasic Sites (AP sites) gene set www.pathwaycomm...
Null Polo-like kinase mediated events View Gene Set 0.004281 10 0.02587 181 REACTOME - Polo-like kinase mediated events gene set www.pathwaycomm...
Null Double-Strand Break Repair View Gene Set 0.004845 27 0.02894 187 REACTOME - Double-Strand Break Repair gene set www.pathwaycomm...
Null Processive synthesis on the C-strand of the telomere View Gene Set 0.005025 11 0.02985 188 REACTOME - Processive synthesis on the C-strand of the telomere gene set www.pathwaycomm...
Null Cyclin A/B1 associated events during G2/M transition View Gene Set 0.005254 19 0.03105 189 REACTOME - Cyclin A/B1 associated events during G2/M transition gene set www.pathwaycomm...
Null Processing of Intronless Pre-mRNAs View Gene Set 0.005489 14 0.03227 190 REACTOME - Processing of Intronless Pre-mRNAs gene set www.pathwaycomm...
Null Transcription of the HIV genome View Gene Set 0.005737 60 0.0335 191 REACTOME - Transcription of the HIV genome gene set www.pathwaycomm...
Null Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex View Gene Set 0.005759 6 0.0335 191 REACTOME - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex gene set www.pathwaycomm...
Null Translation initiation complex formation View Gene Set 0.006336 56 0.03667 193 REACTOME - Translation initiation complex formation gene set www.pathwaycomm...
Null Pyrimidine metabolism View Gene Set 0.006386 23 0.03677 194 REACTOME - Pyrimidine metabolism gene set www.pathwaycomm...
Null Translation View Gene Set 0.00644 120 0.03689 195 REACTOME - Translation gene set www.pathwaycomm...
Null HIV-1 Transcription Initiation View Gene Set 0.007589 40 0.04218 196 REACTOME - HIV-1 Transcription Initiation gene set www.pathwaycomm...
Null RNA Polymerase II HIV-1 Promoter Escape View Gene Set 0.007589 40 0.04218 196 REACTOME - RNA Polymerase II HIV-1 Promoter Escape gene set www.pathwaycomm...
Null RNA Polymerase II Promoter Escape View Gene Set 0.007589 40 0.04218 196 REACTOME - RNA Polymerase II Promoter Escape gene set www.pathwaycomm...
Null RNA Polymerase II Transcription Initiation And Promoter Clearance View Gene Set 0.007589 40 0.04218 196 REACTOME - RNA Polymerase II Transcription Initiation And Promoter Clearance gene set www.pathwaycomm...
Null RNA Polymerase II Transcription Initiation View Gene Set 0.007589 40 0.04218 196 REACTOME - RNA Polymerase II Transcription Initiation gene set www.pathwaycomm...

Gene Set Collection: mirbase.targets

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null hsa-miR-566 View Gene Set 5.587e-09 787 3.972e-06 1 microRNA targets for hsa-miR-566 from mirbase.targets www.mirbase.org...
Null hsa-miR-146b-3p View Gene Set 1.547e-08 695 5.501e-06 2 microRNA targets for hsa-miR-146b-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-941 View Gene Set 1.114e-06 590 0.0002641 3 microRNA targets for hsa-miR-941 from mirbase.targets www.mirbase.org...
Null hsa-miR-486-3p View Gene Set 6.183e-06 773 0.001099 4 microRNA targets for hsa-miR-486-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-602 View Gene Set 1.527e-05 710 0.002172 5 microRNA targets for hsa-miR-602 from mirbase.targets www.mirbase.org...
Null hsa-miR-548d-3p View Gene Set 2.992e-05 978 0.003546 6 microRNA targets for hsa-miR-548d-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-874 View Gene Set 9.578e-05 722 0.009729 7 microRNA targets for hsa-miR-874 from mirbase.targets www.mirbase.org...
Null hsa-miR-611 View Gene Set 0.000126 671 0.0112 8 microRNA targets for hsa-miR-611 from mirbase.targets www.mirbase.org...
Null hsa-miR-324-3p View Gene Set 0.0001597 788 0.01197 9 microRNA targets for hsa-miR-324-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-886-3p View Gene Set 0.0001683 745 0.01197 9 microRNA targets for hsa-miR-886-3p from mirbase.targets www.mirbase.org...
Null hsa-let-7c View Gene Set 0.0002241 760 0.01226 11 microRNA targets for hsa-let-7c from mirbase.targets www.mirbase.org...
Null hsa-miR-17 View Gene Set 0.0002138 935 0.01226 11 microRNA targets for hsa-miR-17 from mirbase.targets www.mirbase.org...
Null hsa-miR-214 View Gene Set 0.0002231 797 0.01226 11 microRNA targets for hsa-miR-214 from mirbase.targets www.mirbase.org...
Null hsa-miR-20a View Gene Set 0.0003561 823 0.01407 14 microRNA targets for hsa-miR-20a from mirbase.targets www.mirbase.org...
Null hsa-miR-20b View Gene Set 0.0003161 901 0.01407 14 microRNA targets for hsa-miR-20b from mirbase.targets www.mirbase.org...
Null hsa-miR-483-5p View Gene Set 0.0002954 717 0.01407 14 microRNA targets for hsa-miR-483-5p from mirbase.targets www.mirbase.org...
Null hsa-miR-615-3p View Gene Set 0.0003408 757 0.01407 14 microRNA targets for hsa-miR-615-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-99b View Gene Set 0.0003444 708 0.01407 14 microRNA targets for hsa-miR-99b from mirbase.targets www.mirbase.org...
Null hsa-miR-604 View Gene Set 0.0004619 691 0.01728 19 microRNA targets for hsa-miR-604 from mirbase.targets www.mirbase.org...
Null hsa-let-7b View Gene Set 0.000556 775 0.01977 20 microRNA targets for hsa-let-7b from mirbase.targets www.mirbase.org...
Null hsa-miR-551b View Gene Set 0.000619 665 0.02096 21 microRNA targets for hsa-miR-551b from mirbase.targets www.mirbase.org...
Null hsa-miR-106b View Gene Set 0.0007747 872 0.02295 22 microRNA targets for hsa-miR-106b from mirbase.targets www.mirbase.org...
Null hsa-miR-212 View Gene Set 0.0007694 803 0.02295 22 microRNA targets for hsa-miR-212 from mirbase.targets www.mirbase.org...
Null hsa-miR-323-5p View Gene Set 0.0007188 763 0.02295 22 microRNA targets for hsa-miR-323-5p from mirbase.targets www.mirbase.org...
Null hsa-miR-381 View Gene Set 0.0008121 643 0.0231 25 microRNA targets for hsa-miR-381 from mirbase.targets www.mirbase.org...
Null hsa-miR-512-3p View Gene Set 0.0009632 697 0.02362 26 microRNA targets for hsa-miR-512-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-635 View Gene Set 0.0009099 648 0.02362 26 microRNA targets for hsa-miR-635 from mirbase.targets www.mirbase.org...
Null hsa-miR-650 View Gene Set 0.0009323 693 0.02362 26 microRNA targets for hsa-miR-650 from mirbase.targets www.mirbase.org...
Null hsa-miR-662 View Gene Set 0.0009528 663 0.02362 26 microRNA targets for hsa-miR-662 from mirbase.targets www.mirbase.org...
Null hsa-miR-331-3p View Gene Set 0.001021 712 0.0242 30 microRNA targets for hsa-miR-331-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-758 View Gene Set 0.001248 660 0.02862 31 microRNA targets for hsa-miR-758 from mirbase.targets www.mirbase.org...
Null hsa-miR-106a View Gene Set 0.001341 774 0.0298 32 microRNA targets for hsa-miR-106a from mirbase.targets www.mirbase.org...
Null hsa-miR-638 View Gene Set 0.001486 639 0.03201 33 microRNA targets for hsa-miR-638 from mirbase.targets www.mirbase.org...
Null hsa-miR-378* View Gene Set 0.00161 686 0.03366 34 microRNA targets for hsa-miR-378* from mirbase.targets www.mirbase.org...
Null hsa-miR-503 View Gene Set 0.001689 748 0.03432 35 microRNA targets for hsa-miR-503 from mirbase.targets www.mirbase.org...
Null hsa-miR-197 View Gene Set 0.001787 609 0.03529 36 microRNA targets for hsa-miR-197 from mirbase.targets www.mirbase.org...
Null hsa-let-7a View Gene Set 0.001905 808 0.03661 37 microRNA targets for hsa-let-7a from mirbase.targets www.mirbase.org...
Null hsa-let-7g* View Gene Set 0.002105 827 0.03938 38 microRNA targets for hsa-let-7g* from mirbase.targets www.mirbase.org...
Null hsa-miR-658 View Gene Set 0.002219 660 0.04046 39 microRNA targets for hsa-miR-658 from mirbase.targets www.mirbase.org...
Null hsa-let-7e View Gene Set 0.002425 778 0.04177 40 microRNA targets for hsa-let-7e from mirbase.targets www.mirbase.org...
Null hsa-miR-497 View Gene Set 0.002585 805 0.04177 40 microRNA targets for hsa-miR-497 from mirbase.targets www.mirbase.org...
Null hsa-miR-597 View Gene Set 0.002468 645 0.04177 40 microRNA targets for hsa-miR-597 from mirbase.targets www.mirbase.org...
Null hsa-miR-767-5p View Gene Set 0.002502 669 0.04177 40 microRNA targets for hsa-miR-767-5p from mirbase.targets www.mirbase.org...
Null hsa-miR-940 View Gene Set 0.002547 660 0.04177 40 microRNA targets for hsa-miR-940 from mirbase.targets www.mirbase.org...
Null hsa-miR-661 View Gene Set 0.002879 575 0.0455 45 microRNA targets for hsa-miR-661 from mirbase.targets www.mirbase.org...
Null hsa-miR-193a-3p View Gene Set 0.00297 722 0.0459 46 microRNA targets for hsa-miR-193a-3p from mirbase.targets www.mirbase.org...
Null hsa-miR-640 View Gene Set 0.00313 704 0.04736 47 microRNA targets for hsa-miR-640 from mirbase.targets www.mirbase.org...

Gene Set Collection: miRNAtargetUnion

Arguments: refPop=all, featureType=featureNames, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-566 View Gene Set 9.738e-06 1066 0.02253 1 microRNA targets for miranda.mirbase.mirtarget2.targetsUnion.hsa-miR-566 from miRNAtargetUnion www.mirbase.org...