Results

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Go to: Gene Set Collection: KEGG
Go to: Gene Set Collection: GO
Go to: Gene Set Collection: Broad.c2.CGP
Go to: Gene Set Collection: Broad.c2.CP
Go to: Gene Set Collection: Broad.c2.CP.BIOCARTA
Go to: Gene Set Collection: Broad.c2.CP.KEGG
Go to: Gene Set Collection: Broad.c2.CP.REACTOME
Go to: Gene Set Collection: Broad.c3.MIR
Go to: Gene Set Collection: Broad.c3.TFT
Go to: Gene Set Collection: Broad.c4.CGN
Go to: Gene Set Collection: Broad.c4.CM
Go to: Gene Set Collection: Broad.c5.BP
Go to: Gene Set Collection: Broad.c5.CC
Go to: Gene Set Collection: Broad.c5.MF
Go to: Gene Set Collection: PMID
Go to: Gene Set Collection: ChromosomalTiles5Mb
Go to: Gene Set Collection: Prosite
Go to: Gene Set Collection: Enzyme
Go to: Gene Set Collection: ppi.BIND
Go to: Gene Set Collection: ppi.BioGRID
Go to: Gene Set Collection: ppi.HPRD
Go to: Gene Set Collection: ppi.anyDB
Go to: Gene Set Collection: pathwayCommons.cell-map
Go to: Gene Set Collection: pathwayCommons.humancyc
Go to: Gene Set Collection: pathwayCommons.nci-nature
Go to: Gene Set Collection: pathwayCommons.reactome
Go to: Gene Set Collection: miranda.targets
Go to: Gene Set Collection: mirbase.targets
Go to: Gene Set Collection: mirtarget2.targets
Go to: Gene Set Collection: pictar.targets
Go to: Gene Set Collection: tarbase.targets
Go to: Gene Set Collection: targetscan.targets
Go to: Gene Set Collection: miRNAtargetIntersection
Go to: Gene Set Collection: miRNAtargetUnion
Go to: Gene Set Collection: hprdBatch.UP
Go to: Gene Set Collection: hprdBatch.DOWN
Go to: Gene Set Collection: hprdBatch.DIFFERENT
Go to: Gene Set Collection: hprdManual.UP
Go to: Gene Set Collection: hprdManual.DIFFERENT
Go to: Gene Set Collection: tfbsK3Z3

AFA results for: AllvsControl

Click on the heading for any column to sort by that column.

Gene Set Collection: KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
KEGG 03040 View Gene Set 4.235e-23 128 9.062e-21 1 Spliceosome www.genome.jp/d...
KEGG 03010 View Gene Set 3.772e-21 88 4.036e-19 2 Ribosome www.genome.jp/d...
KEGG 01100 View Gene Set 2.256e-20 1120 1.61e-18 3 Metabolic pathways www.genome.jp/d...
KEGG 04141 View Gene Set 3.262e-20 167 1.745e-18 4 Protein processing in endoplasmic reticulum www.genome.jp/d...
KEGG 04110 View Gene Set 1.909e-16 128 8.169e-15 5 Cell cycle www.genome.jp/d...
KEGG 05016 View Gene Set 1.51e-12 184 5.384e-11 6 Huntington's disease www.genome.jp/d...
KEGG 04120 View Gene Set 9.647e-12 139 2.949e-10 7 Ubiquitin mediated proteolysis www.genome.jp/d...
KEGG 00190 View Gene Set 1.132e-11 134 3.027e-10 8 Oxidative phosphorylation www.genome.jp/d...
KEGG 00240 View Gene Set 1.707e-11 99 4.059e-10 9 Pyrimidine metabolism www.genome.jp/d...
KEGG 05012 View Gene Set 7.698e-11 132 1.647e-09 10 Parkinson's disease www.genome.jp/d...
KEGG 03018 View Gene Set 2.226e-10 59 4.33e-09 11 RNA degradation www.genome.jp/d...
KEGG 05010 View Gene Set 1.65e-09 168 2.942e-08 12 Alzheimer's disease www.genome.jp/d...
KEGG 00970 View Gene Set 1.706e-08 41 2.808e-07 13 Aminoacyl-tRNA biosynthesis www.genome.jp/d...
KEGG 04114 View Gene Set 3.882e-08 114 5.935e-07 14 Oocyte meiosis www.genome.jp/d...
KEGG 03030 View Gene Set 1.24e-07 36 1.77e-06 15 DNA replication www.genome.jp/d...
KEGG 00510 View Gene Set 6.96e-07 48 9.029e-06 16 N-Glycan biosynthesis www.genome.jp/d...
KEGG 03060 View Gene Set 7.173e-07 24 9.029e-06 16 Protein export www.genome.jp/d...
KEGG 00020 View Gene Set 1.032e-06 31 1.227e-05 18 Citrate cycle (TCA cycle) www.genome.jp/d...
KEGG 05131 View Gene Set 1.139e-06 64 1.282e-05 19 Shigellosis www.genome.jp/d...
KEGG 03050 View Gene Set 6.011e-06 48 6.432e-05 20 Proteasome www.genome.jp/d...
KEGG 03410 View Gene Set 8.894e-06 34 9.064e-05 21 Base excision repair www.genome.jp/d...
KEGG 03420 View Gene Set 1.021e-05 44 9.927e-05 22 Nucleotide excision repair www.genome.jp/d...
KEGG 04146 View Gene Set 2.365e-05 78 0.00022 23 Peroxisome www.genome.jp/d...
KEGG 00230 View Gene Set 2.781e-05 161 0.0002479 24 Purine metabolism www.genome.jp/d...
KEGG 04914 View Gene Set 5.075e-05 87 0.0004344 25 Progesterone-mediated oocyte maturation www.genome.jp/d...
KEGG 05213 View Gene Set 0.0001076 52 0.0008646 26 Endometrial cancer www.genome.jp/d...
KEGG 05220 View Gene Set 0.0001091 73 0.0008646 26 Chronic myeloid leukemia www.genome.jp/d...
KEGG 00270 View Gene Set 0.0001165 34 0.0008907 28 Cysteine and methionine metabolism www.genome.jp/d...
KEGG 04150 View Gene Set 0.000135 52 0.0009962 29 mTOR signaling pathway www.genome.jp/d...
KEGG 04210 View Gene Set 0.0001466 88 0.001046 30 Apoptosis www.genome.jp/d...
KEGG 00290 View Gene Set 0.0001637 11 0.00113 31 Valine leucine and isoleucine biosynthesis www.genome.jp/d...
KEGG 05223 View Gene Set 0.0002164 54 0.001447 32 Non-small cell lung cancer www.genome.jp/d...
KEGG 05212 View Gene Set 0.0002427 70 0.001574 33 Pancreatic cancer www.genome.jp/d...
KEGG 05215 View Gene Set 0.0002524 89 0.001588 34 Prostate cancer www.genome.jp/d...
KEGG 00280 View Gene Set 0.0004325 44 0.002644 35 Valine leucine and isoleucine degradation www.genome.jp/d...
KEGG 03430 View Gene Set 0.0005584 23 0.003319 36 Mismatch repair www.genome.jp/d...
KEGG 03020 View Gene Set 0.0006618 29 0.003827 37 RNA polymerase www.genome.jp/d...
KEGG 05210 View Gene Set 0.0007932 62 0.004467 38 Colorectal cancer www.genome.jp/d...
KEGG 05100 View Gene Set 0.0009172 73 0.005033 39 Bacterial invasion of epithelial cells www.genome.jp/d...
KEGG 05221 View Gene Set 0.000974 60 0.005211 40 Acute myeloid leukemia www.genome.jp/d...
KEGG 00640 View Gene Set 0.001199 33 0.006259 41 Propanoate metabolism www.genome.jp/d...
KEGG 05222 View Gene Set 0.0013 84 0.006624 42 Small cell lung cancer www.genome.jp/d...
KEGG 00100 View Gene Set 0.001668 17 0.008299 43 Steroid biosynthesis www.genome.jp/d...
KEGG 00310 View Gene Set 0.00189 46 0.008976 44 Lysine degradation www.genome.jp/d...
KEGG 00670 View Gene Set 0.001916 17 0.008976 44 One carbon pool by folate www.genome.jp/d...
KEGG 04330 View Gene Set 0.001929 47 0.008976 44 Notch signaling pathway www.genome.jp/d...
KEGG 05130 View Gene Set 0.002342 59 0.01066 47 Pathogenic Escherichia coli infection www.genome.jp/d...
KEGG 00620 View Gene Set 0.003748 40 0.01671 48 Pyruvate metabolism www.genome.jp/d...
KEGG 00750 View Gene Set 0.004617 6 0.02016 49 Vitamin B6 metabolism www.genome.jp/d...
KEGG 04910 View Gene Set 0.005358 137 0.02293 50 Insulin signaling pathway www.genome.jp/d...
KEGG 05014 View Gene Set 0.006283 53 0.02637 51 Amyotrophic lateral sclerosis (ALS) www.genome.jp/d...
KEGG 05211 View Gene Set 0.007121 70 0.0293 52 Renal cell carcinoma www.genome.jp/d...
KEGG 03440 View Gene Set 0.008695 28 0.03458 53 Homologous recombination www.genome.jp/d...
KEGG 05216 View Gene Set 0.008726 29 0.03458 53 Thyroid cancer www.genome.jp/d...

Gene Set Collection: GO

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
GO GO:0044424 View Gene Set 1.353e-168 10976 1.808e-164 1 intracellular part amigo.geneontol...
GO GO:0043227 View Gene Set 1.502e-167 8383 9.929e-164 2 membrane-bounded organelle amigo.geneontol...
GO GO:0043231 View Gene Set 2.229e-167 8376 9.929e-164 2 intracellular membrane-bounded organelle amigo.geneontol...
GO GO:0005622 View Gene Set 1.752e-159 11329 5.853e-156 4 intracellular amigo.geneontol...
GO GO:0043229 View Gene Set 7.705e-156 9346 2.059e-152 5 intracellular organelle amigo.geneontol...
GO GO:0043226 View Gene Set 9.496e-155 9360 2.114e-151 6 organelle amigo.geneontol...
GO GO:0044446 View Gene Set 1.458e-129 5019 2.783e-126 7 intracellular organelle part amigo.geneontol...
GO GO:0044422 View Gene Set 2.687e-125 5089 4.487e-122 8 organelle part amigo.geneontol...
GO GO:0070013 View Gene Set 2.532e-115 1845 3.759e-112 9 intracellular organelle lumen amigo.geneontol...
GO GO:0031974 View Gene Set 7.722e-113 1917 1.032e-109 10 membrane-enclosed lumen amigo.geneontol...
GO GO:0043233 View Gene Set 3.686e-110 1881 4.477e-107 11 organelle lumen amigo.geneontol...
GO GO:0005737 View Gene Set 6.836e-110 7676 7.611e-107 12 cytoplasm amigo.geneontol...
GO GO:0044428 View Gene Set 4.81e-107 1938 4.943e-104 13 nuclear part amigo.geneontol...
GO GO:0005634 View Gene Set 5.86e-97 5198 5.592e-94 14 nucleus amigo.geneontol...
GO GO:0044444 View Gene Set 5.12e-92 5184 4.561e-89 15 cytoplasmic part amigo.geneontol...
GO GO:0044237 View Gene Set 1.027e-87 7431 8.571e-85 16 cellular metabolic process amigo.geneontol...
GO GO:0031981 View Gene Set 1.06e-86 1518 8.33e-84 17 nuclear lumen amigo.geneontol...
GO GO:0030529 View Gene Set 5.256e-86 504 3.901e-83 18 ribonucleoprotein complex amigo.geneontol...
GO GO:0003723 View Gene Set 2.212e-85 732 1.556e-82 19 RNA binding amigo.geneontol...
GO GO:0044260 View Gene Set 4.1e-84 5699 2.739e-81 20 cellular macromolecule metabolic process amigo.geneontol...
GO GO:0005739 View Gene Set 9.491e-76 1274 6.038e-73 21 mitochondrion amigo.geneontol...
GO GO:0032991 View Gene Set 3.662e-75 3237 2.224e-72 22 macromolecular complex amigo.geneontol...
GO GO:0006396 View Gene Set 1.526e-68 578 8.867e-66 23 RNA processing amigo.geneontol...
GO GO:0008152 View Gene Set 3.596e-67 8439 2.002e-64 24 metabolic process amigo.geneontol...
GO GO:0043170 View Gene Set 8.553e-65 6274 4.571e-62 25 macromolecule metabolic process amigo.geneontol...
GO GO:0044238 View Gene Set 9.007e-65 7629 4.628e-62 26 primary metabolic process amigo.geneontol...
GO GO:0005623 View Gene Set 1.79e-59 15067 8.568e-57 27 cell amigo.geneontol...
GO GO:0044464 View Gene Set 1.796e-59 15066 8.568e-57 27 cell part amigo.geneontol...
GO GO:0006412 View Gene Set 2.105e-58 412 9.698e-56 29 translation amigo.geneontol...
GO GO:0005654 View Gene Set 1.698e-55 939 7.563e-53 30 nucleoplasm amigo.geneontol...
GO GO:0043228 View Gene Set 9.239e-53 2690 3.857e-50 31 non-membrane-bounded organelle amigo.geneontol...
GO GO:0043232 View Gene Set 9.239e-53 2690 3.857e-50 31 intracellular non-membrane-bounded organelle amigo.geneontol...
GO GO:0010467 View Gene Set 1.439e-51 3806 5.826e-49 33 gene expression amigo.geneontol...
GO GO:0044267 View Gene Set 3.142e-50 2465 1.235e-47 34 cellular protein metabolic process amigo.geneontol...
GO GO:0005730 View Gene Set 9.92e-50 734 3.787e-47 35 nucleolus amigo.geneontol...
GO GO:0090304 View Gene Set 1.757e-49 3724 6.52e-47 36 nucleic acid metabolic process amigo.geneontol...
GO GO:0034641 View Gene Set 7.107e-49 4584 2.566e-46 37 cellular nitrogen compound metabolic process amigo.geneontol...
GO GO:0044429 View Gene Set 2.328e-46 619 8.184e-44 38 mitochondrial part amigo.geneontol...
GO GO:0006807 View Gene Set 5.426e-46 4698 1.859e-43 39 nitrogen compound metabolic process amigo.geneontol...
GO GO:0006139 View Gene Set 6.847e-46 4294 2.287e-43 40 nucleobase nucleoside nucleotide and nucleic acid metabolic process amigo.geneontol...
GO GO:0009987 View Gene Set 7.847e-46 11620 2.557e-43 41 cellular process amigo.geneontol...
GO GO:0005840 View Gene Set 2.368e-44 198 7.532e-42 42 ribosome amigo.geneontol...
GO GO:0005515 View Gene Set 1.76e-43 8146 5.469e-41 43 protein binding amigo.geneontol...
GO GO:0022613 View Gene Set 1.951e-43 194 5.924e-41 44 ribonucleoprotein complex biogenesis amigo.geneontol...
GO GO:0003824 View Gene Set 4.076e-43 5198 1.21e-40 45 catalytic activity amigo.geneontol...
GO GO:0003676 View Gene Set 4.219e-43 2979 1.225e-40 46 nucleic acid binding amigo.geneontol...
GO GO:0005488 View Gene Set 1.224e-41 12334 3.48e-39 47 binding amigo.geneontol...
GO GO:0008380 View Gene Set 3.28e-39 300 9.131e-37 48 RNA splicing amigo.geneontol...
GO GO:0031967 View Gene Set 1.047e-38 672 2.853e-36 49 organelle envelope amigo.geneontol...
GO GO:0034660 View Gene Set 2.904e-37 236 7.761e-35 50 ncRNA metabolic process amigo.geneontol...
GO GO:0031975 View Gene Set 6.371e-37 685 1.669e-34 51 envelope amigo.geneontol...
GO GO:0005694 View Gene Set 1.905e-36 507 4.895e-34 52 chromosome amigo.geneontol...
GO GO:0003735 View Gene Set 2.508e-36 158 6.323e-34 53 structural constituent of ribosome amigo.geneontol...
GO GO:0016071 View Gene Set 3.038e-36 381 7.516e-34 54 mRNA metabolic process amigo.geneontol...
GO GO:0044249 View Gene Set 1.415e-35 4326 3.436e-33 55 cellular biosynthetic process amigo.geneontol...
GO GO:0034470 View Gene Set 2.343e-34 193 5.59e-32 56 ncRNA processing amigo.geneontol...
GO GO:0009058 View Gene Set 2.55e-34 4436 5.976e-32 57 biosynthetic process amigo.geneontol...
GO GO:0007049 View Gene Set 1.144e-33 1006 2.636e-31 58 cell cycle amigo.geneontol...
GO GO:0005829 View Gene Set 4.34e-33 1323 9.828e-31 59 cytosol amigo.geneontol...
GO GO:0000166 View Gene Set 4.661e-33 2257 1.038e-30 60 nucleotide binding amigo.geneontol...
GO GO:0019538 View Gene Set 1.041e-32 2935 2.281e-30 61 protein metabolic process amigo.geneontol...
GO GO:0034645 View Gene Set 1.305e-32 3529 2.813e-30 62 cellular macromolecule biosynthetic process amigo.geneontol...
GO GO:0006397 View Gene Set 7.895e-32 317 1.674e-29 63 mRNA processing amigo.geneontol...
GO GO:0042254 View Gene Set 8.4e-32 130 1.753e-29 64 ribosome biogenesis amigo.geneontol...
GO GO:0043234 View Gene Set 1.535e-31 2680 3.155e-29 65 protein complex amigo.geneontol...
GO GO:0003674 View Gene Set 6.418e-31 15462 1.299e-28 66 molecular_function amigo.geneontol...
GO GO:0006996 View Gene Set 7.423e-31 1501 1.48e-28 67 organelle organization amigo.geneontol...
GO GO:0044427 View Gene Set 8.222e-31 420 1.615e-28 68 chromosomal part amigo.geneontol...
GO GO:0009059 View Gene Set 3.217e-30 3597 6.229e-28 69 macromolecule biosynthetic process amigo.geneontol...
GO GO:0046907 View Gene Set 3.335e-30 753 6.365e-28 70 intracellular transport amigo.geneontol...
GO GO:0005575 View Gene Set 2.629e-29 16391 4.948e-27 71 cellular_component amigo.geneontol...
GO GO:0033279 View Gene Set 9.375e-29 121 1.74e-26 72 ribosomal subunit amigo.geneontol...
GO GO:0044451 View Gene Set 1.027e-28 600 1.88e-26 73 nucleoplasm part amigo.geneontol...
GO GO:0006259 View Gene Set 1.288e-28 592 2.325e-26 74 DNA metabolic process amigo.geneontol...
GO GO:0005740 View Gene Set 1.468e-28 444 2.615e-26 75 mitochondrial envelope amigo.geneontol...
GO GO:0031090 View Gene Set 2.084e-28 1905 3.664e-26 76 organelle membrane amigo.geneontol...
GO GO:0008150 View Gene Set 9.247e-28 14318 1.604e-25 77 biological_process amigo.geneontol...
GO GO:0016070 View Gene Set 9.816e-28 2596 1.681e-25 78 RNA metabolic process amigo.geneontol...
GO GO:0031966 View Gene Set 2.833e-27 420 4.791e-25 79 mitochondrial membrane amigo.geneontol...
GO GO:0005759 View Gene Set 6.368e-27 223 1.05e-24 80 mitochondrial matrix amigo.geneontol...
GO GO:0031980 View Gene Set 6.368e-27 223 1.05e-24 80 mitochondrial lumen amigo.geneontol...
GO GO:0000278 View Gene Set 1.693e-26 489 2.758e-24 82 mitotic cell cycle amigo.geneontol...
GO GO:0044265 View Gene Set 2.493e-25 479 4.013e-23 83 cellular macromolecule catabolic process amigo.geneontol...
GO GO:0022402 View Gene Set 2.824e-25 676 4.491e-23 84 cell cycle process amigo.geneontol...
GO GO:0051276 View Gene Set 3.698e-25 548 5.812e-23 85 chromosome organization amigo.geneontol...
GO GO:0006364 View Gene Set 1.316e-24 97 2.045e-22 86 rRNA processing amigo.geneontol...
GO GO:0006414 View Gene Set 1.36e-24 104 2.088e-22 87 translational elongation amigo.geneontol...
GO GO:0044085 View Gene Set 4.566e-24 1167 6.932e-22 88 cellular component biogenesis amigo.geneontol...
GO GO:0016072 View Gene Set 8.514e-24 101 1.278e-21 89 rRNA metabolic process amigo.geneontol...
GO GO:0006974 View Gene Set 1.061e-23 412 1.574e-21 90 response to DNA damage stimulus amigo.geneontol...
GO GO:0045184 View Gene Set 3.587e-23 904 5.267e-21 91 establishment of protein localization amigo.geneontol...
GO GO:0015031 View Gene Set 4.854e-23 888 7.049e-21 92 protein transport amigo.geneontol...
GO GO:0070647 View Gene Set 6.066e-23 356 8.715e-21 93 protein modification by small protein conjugation or removal amigo.geneontol...
GO GO:0008104 View Gene Set 2.361e-22 1048 3.322e-20 94 protein localization amigo.geneontol...
GO GO:0032446 View Gene Set 2.362e-22 310 3.322e-20 94 protein modification by small protein conjugation amigo.geneontol...
GO GO:0048285 View Gene Set 5.434e-22 286 7.562e-20 96 organelle fission amigo.geneontol...
GO GO:0022403 View Gene Set 5.813e-22 522 8.007e-20 97 cell cycle phase amigo.geneontol...
GO GO:0019866 View Gene Set 8.032e-22 334 1.095e-19 98 organelle inner membrane amigo.geneontol...
GO GO:0000280 View Gene Set 9.134e-22 276 1.22e-19 99 nuclear division amigo.geneontol...
GO GO:0007067 View Gene Set 9.134e-22 276 1.22e-19 99 mitosis amigo.geneontol...
GO GO:0000775 View Gene Set 1.717e-21 146 2.271e-19 101 chromosome centromeric region amigo.geneontol...
GO GO:0000087 View Gene Set 3.802e-21 286 4.98e-19 102 M phase of mitotic cell cycle amigo.geneontol...
GO GO:0000279 View Gene Set 3.941e-21 406 5.111e-19 103 M phase amigo.geneontol...
GO GO:0051301 View Gene Set 5.165e-21 358 6.634e-19 104 cell division amigo.geneontol...
GO GO:0009057 View Gene Set 6.344e-21 570 8.072e-19 105 macromolecule catabolic process amigo.geneontol...
GO GO:0006457 View Gene Set 1.681e-20 172 2.119e-18 106 protein folding amigo.geneontol...
GO GO:0005743 View Gene Set 1.76e-20 305 2.197e-18 107 mitochondrial inner membrane amigo.geneontol...
GO GO:0005681 View Gene Set 2.358e-20 135 2.917e-18 108 spliceosomal complex amigo.geneontol...
GO GO:0033036 View Gene Set 3.816e-20 1256 4.677e-18 109 macromolecule localization amigo.geneontol...
GO GO:0034621 View Gene Set 8.608e-20 458 1.046e-17 110 cellular macromolecular complex subunit organization amigo.geneontol...
GO GO:0016567 View Gene Set 9.659e-20 286 1.163e-17 111 protein ubiquitination amigo.geneontol...
GO GO:0000375 View Gene Set 1.032e-19 106 1.231e-17 112 RNA splicing via transesterification reactions amigo.geneontol...
GO GO:0005819 View Gene Set 1.967e-19 167 2.326e-17 113 spindle amigo.geneontol...
GO GO:0043933 View Gene Set 3.042e-19 836 3.565e-17 114 macromolecular complex subunit organization amigo.geneontol...
GO GO:0070727 View Gene Set 3.132e-19 503 3.638e-17 115 cellular macromolecule localization amigo.geneontol...
GO GO:0006399 View Gene Set 3.736e-19 118 4.302e-17 116 tRNA metabolic process amigo.geneontol...
GO GO:0034613 View Gene Set 5.839e-19 501 6.668e-17 117 cellular protein localization amigo.geneontol...
GO GO:0000377 View Gene Set 6.193e-19 97 6.953e-17 118 RNA splicing via transesterification reactions with bulged adenosine as nucleophile amigo.geneontol...
GO GO:0000398 View Gene Set 6.193e-19 97 6.953e-17 118 nuclear mRNA splicing via spliceosome amigo.geneontol...
GO GO:0016604 View Gene Set 7.574e-19 198 8.433e-17 120 nuclear body amigo.geneontol...
GO GO:0019941 View Gene Set 1.118e-18 302 1.224e-16 121 modification-dependent protein catabolic process amigo.geneontol...
GO GO:0043632 View Gene Set 1.118e-18 302 1.224e-16 121 modification-dependent macromolecule catabolic process amigo.geneontol...
GO GO:0006281 View Gene Set 1.218e-18 309 1.323e-16 123 DNA repair amigo.geneontol...
GO GO:0006886 View Gene Set 1.415e-18 439 1.524e-16 124 intracellular protein transport amigo.geneontol...
GO GO:0000793 View Gene Set 1.554e-18 136 1.661e-16 125 condensed chromosome amigo.geneontol...
GO GO:0006511 View Gene Set 1.627e-18 296 1.725e-16 126 ubiquitin-dependent protein catabolic process amigo.geneontol...
GO GO:0051603 View Gene Set 4.163e-18 346 4.379e-16 127 proteolysis involved in cellular protein catabolic process amigo.geneontol...
GO GO:0065003 View Gene Set 5.899e-18 763 6.157e-16 128 macromolecular complex assembly amigo.geneontol...
GO GO:0044257 View Gene Set 1.104e-17 349 1.143e-15 129 cellular protein catabolic process amigo.geneontol...
GO GO:0016874 View Gene Set 1.962e-17 436 2.016e-15 130 ligase activity amigo.geneontol...
GO GO:0006260 View Gene Set 2.209e-17 239 2.253e-15 131 DNA replication amigo.geneontol...
GO GO:0017076 View Gene Set 4.369e-17 1934 4.422e-15 132 purine nucleotide binding amigo.geneontol...
GO GO:0010498 View Gene Set 5e-17 166 5.023e-15 133 proteasomal protein catabolic process amigo.geneontol...
GO GO:0030163 View Gene Set 1.333e-16 398 1.329e-14 134 protein catabolic process amigo.geneontol...
GO GO:0015934 View Gene Set 1.429e-16 64 1.414e-14 135 large ribosomal subunit amigo.geneontol...
GO GO:0022626 View Gene Set 1.813e-16 75 1.781e-14 136 cytosolic ribosome amigo.geneontol...
GO GO:0034622 View Gene Set 2.151e-16 393 2.097e-14 137 cellular macromolecular complex assembly amigo.geneontol...
GO GO:0006325 View Gene Set 2.41e-16 425 2.333e-14 138 chromatin organization amigo.geneontol...
GO GO:0043161 View Gene Set 3.225e-16 162 3.1e-14 139 proteasomal ubiquitin-dependent protein catabolic process amigo.geneontol...
GO GO:0016568 View Gene Set 3.581e-16 324 3.417e-14 140 chromatin modification amigo.geneontol...
GO GO:0022618 View Gene Set 4.317e-16 76 4.091e-14 141 ribonucleoprotein complex assembly amigo.geneontol...
GO GO:0000776 View Gene Set 5.24e-16 92 4.93e-14 142 kinetochore amigo.geneontol...
GO GO:0032553 View Gene Set 2.118e-15 1851 1.965e-13 143 ribonucleotide binding amigo.geneontol...
GO GO:0032555 View Gene Set 2.118e-15 1851 1.965e-13 143 purine ribonucleotide binding amigo.geneontol...
GO GO:0044455 View Gene Set 2.518e-15 133 2.32e-13 145 mitochondrial membrane part amigo.geneontol...
GO GO:0044419 View Gene Set 2.805e-15 343 2.567e-13 146 interspecies interaction between organisms amigo.geneontol...
GO GO:0000228 View Gene Set 3.969e-15 177 3.607e-13 147 nuclear chromosome amigo.geneontol...
GO GO:0008135 View Gene Set 4.426e-15 86 3.995e-13 148 translation factor activity nucleic acid binding amigo.geneontol...
GO GO:0015935 View Gene Set 5.686e-15 59 5.099e-13 149 small ribosomal subunit amigo.geneontol...
GO GO:0016043 View Gene Set 9.806e-15 2937 8.734e-13 150 cellular component organization amigo.geneontol...
GO GO:0033554 View Gene Set 1.025e-14 698 9.072e-13 151 cellular response to stress amigo.geneontol...
GO GO:0044445 View Gene Set 1.406e-14 148 1.236e-12 152 cytosolic part amigo.geneontol...
GO GO:0008168 View Gene Set 2.02e-14 176 1.764e-12 153 methyltransferase activity amigo.geneontol...
GO GO:0016741 View Gene Set 2.104e-14 179 1.826e-12 154 transferase activity transferring one-carbon groups amigo.geneontol...
GO GO:0006403 View Gene Set 2.179e-14 104 1.878e-12 155 RNA localization amigo.geneontol...
GO GO:0051649 View Gene Set 2.387e-14 1116 2.044e-12 156 establishment of localization in cell amigo.geneontol...
GO GO:0050657 View Gene Set 2.64e-14 102 2.218e-12 157 nucleic acid transport amigo.geneontol...
GO GO:0050658 View Gene Set 2.64e-14 102 2.218e-12 157 RNA transport amigo.geneontol...
GO GO:0051236 View Gene Set 2.64e-14 102 2.218e-12 157 establishment of RNA localization amigo.geneontol...
GO GO:0051641 View Gene Set 2.805e-14 1206 2.342e-12 160 cellular localization amigo.geneontol...
GO GO:0016740 View Gene Set 3.283e-14 1691 2.724e-12 161 transferase activity amigo.geneontol...
GO GO:0010608 View Gene Set 3.942e-14 247 3.251e-12 162 posttranscriptional regulation of gene expression amigo.geneontol...
GO GO:0044248 View Gene Set 5.611e-14 1005 4.599e-12 163 cellular catabolic process amigo.geneontol...
GO GO:0000779 View Gene Set 7.457e-14 79 6.075e-12 164 condensed chromosome centromeric region amigo.geneontol...
GO GO:0001882 View Gene Set 7.856e-14 1630 6.361e-12 165 nucleoside binding amigo.geneontol...
GO GO:0051082 View Gene Set 8.578e-14 113 6.904e-12 166 unfolded protein binding amigo.geneontol...
GO GO:0030554 View Gene Set 8.871e-14 1584 7.097e-12 167 adenyl nucleotide binding amigo.geneontol...
GO GO:0000313 View Gene Set 1.297e-13 49 1.019e-11 168 organellar ribosome amigo.geneontol...
GO GO:0005761 View Gene Set 1.297e-13 49 1.019e-11 168 mitochondrial ribosome amigo.geneontol...
GO GO:0001883 View Gene Set 1.295e-13 1620 1.019e-11 168 purine nucleoside binding amigo.geneontol...
GO GO:0015931 View Gene Set 1.797e-13 118 1.404e-11 171 nucleobase nucleoside nucleotide and nucleic acid transport amigo.geneontol...
GO GO:0000777 View Gene Set 1.923e-13 74 1.485e-11 172 condensed chromosome kinetochore amigo.geneontol...
GO GO:0016853 View Gene Set 1.917e-13 132 1.485e-11 172 isomerase activity amigo.geneontol...
GO GO:0007059 View Gene Set 2.473e-13 94 1.899e-11 174 chromosome segregation amigo.geneontol...
GO GO:0005643 View Gene Set 4.461e-13 71 3.406e-11 175 nuclear pore amigo.geneontol...
GO GO:0006413 View Gene Set 5.476e-13 62 4.157e-11 176 translational initiation amigo.geneontol...
GO GO:0016607 View Gene Set 8.285e-13 116 6.253e-11 177 nuclear speck amigo.geneontol...
GO GO:0046930 View Gene Set 1.564e-12 85 1.174e-10 178 pore complex amigo.geneontol...
GO GO:0005524 View Gene Set 2.218e-12 1480 1.655e-10 179 ATP binding amigo.geneontol...
GO GO:0044454 View Gene Set 2.457e-12 139 1.823e-10 180 nuclear chromosome part amigo.geneontol...
GO GO:0060255 View Gene Set 2.804e-12 3411 2.07e-10 181 regulation of macromolecule metabolic process amigo.geneontol...
GO GO:0008033 View Gene Set 3.087e-12 78 2.266e-10 182 tRNA processing amigo.geneontol...
GO GO:0003743 View Gene Set 3.225e-12 52 2.354e-10 183 translation initiation factor activity amigo.geneontol...
GO GO:0032559 View Gene Set 3.5e-12 1503 2.541e-10 184 adenyl ribonucleotide binding amigo.geneontol...
GO GO:0006839 View Gene Set 4.123e-12 75 2.977e-10 185 mitochondrial transport amigo.geneontol...
GO GO:0051438 View Gene Set 4.325e-12 82 3.107e-10 186 regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0051246 View Gene Set 5.093e-12 652 3.639e-10 187 regulation of protein metabolic process amigo.geneontol...
GO GO:0006417 View Gene Set 5.438e-12 151 3.864e-10 188 regulation of translation amigo.geneontol...
GO GO:0016879 View Gene Set 5.524e-12 273 3.905e-10 189 ligase activity forming carbon-nitrogen bonds amigo.geneontol...
GO GO:0005635 View Gene Set 6.407e-12 234 4.505e-10 190 nuclear envelope amigo.geneontol...
GO GO:0006626 View Gene Set 7.31e-12 32 5.087e-10 191 protein targeting to mitochondrion amigo.geneontol...
GO GO:0070585 View Gene Set 7.31e-12 32 5.087e-10 191 protein localization in mitochondrion amigo.geneontol...
GO GO:0016818 View Gene Set 7.822e-12 765 5.415e-10 193 hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides amigo.geneontol...
GO GO:0005783 View Gene Set 1.25e-11 1024 8.608e-10 194 endoplasmic reticulum amigo.geneontol...
GO GO:0016817 View Gene Set 1.311e-11 769 8.984e-10 195 hydrolase activity acting on acid anhydrides amigo.geneontol...
GO GO:0022607 View Gene Set 1.346e-11 1043 9.176e-10 196 cellular component assembly amigo.geneontol...
GO GO:0008565 View Gene Set 1.422e-11 85 9.642e-10 197 protein transporter activity amigo.geneontol...
GO GO:0016462 View Gene Set 1.457e-11 762 9.832e-10 198 pyrophosphatase activity amigo.geneontol...
GO GO:0044432 View Gene Set 1.896e-11 689 1.273e-09 199 endoplasmic reticulum part amigo.geneontol...
GO GO:0000785 View Gene Set 2.216e-11 213 1.48e-09 200 chromatin amigo.geneontol...

Gene Set Collection: Broad.c2.CGP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP View Gene Set 1.348e-155 1353 3.225e-152 1 Genes up-regulated in CD34+ [Gene ID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients compared to those from normal donors. www.broad.mit.e...
Broad PUJANA_BRCA1_PCC_NETWORK View Gene Set 1.969e-150 1582 2.355e-147 2 Genes constituting the BRCA1-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA1 [Gene ID=672] across a compendium of normal tissues. www.broad.mit.e...
Broad CAIRO_HEPATOBLASTOMA_CLASSES_UP View Gene Set 4.837e-134 577 3.857e-131 3 Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). www.broad.mit.e...
Broad PUJANA_CHEK2_PCC_NETWORK View Gene Set 6.561e-132 744 3.923e-129 4 Genes constituting the CHEK2-PCC network of transcripts whose expression positively correlates (Pearson correlation coefficient PCC >= 0.4) with that of CHEK2 [Gene ID=11200]. www.broad.mit.e...
Broad DODD_NASOPHARYNGEAL_CARCINOMA_DN View Gene Set 6.875e-126 1253 3.289e-123 5 Genes down-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. www.broad.mit.e...
Broad KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP View Gene Set 5.027e-115 1180 2.004e-112 6 Genes up-regulated in TC71 and EWS502 cells (Ewing's sarcoma) upon knockdown of the EWSR1-FLII fusion [Gene ID=2130 2314]. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_24HR_UP View Gene Set 4.997e-85 537 1.707e-82 7 Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. www.broad.mit.e...
Broad WEI_MYCN_TARGETS_WITH_E_BOX View Gene Set 4.098e-83 757 1.225e-80 8 Genes whose promoters contain E-box motifs and whose expression changed in MYCN-3 cells (neuroblastoma) upon induction of MYCN [Gene ID=4613]. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN View Gene Set 5.746e-81 920 1.527e-78 9 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h. www.broad.mit.e...
Broad WONG_EMBRYONIC_STEM_CELL_CORE View Gene Set 2.519e-78 331 6.025e-76 10 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. www.broad.mit.e...
Broad NUYTTEN_EZH2_TARGETS_DN View Gene Set 8.88e-73 859 1.931e-70 11 Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. www.broad.mit.e...
Broad ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP View Gene Set 3.647e-72 806 7.27e-70 12 Genes up-regulated in liver tumor compared to the normal adjacent tissue. www.broad.mit.e...
Broad DANG_BOUND_BY_MYC View Gene Set 1.336e-68 1045 2.459e-66 13 Genes whose promoters are bound by MYC [Gene ID=4609] according to MYC Target Gene Database. www.broad.mit.e...
Broad CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN View Gene Set 2.295e-68 639 3.92e-66 14 Genes down-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [Gene ID=5371 5914] compared to normal promyeloblasts. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP View Gene Set 1.567e-67 589 2.499e-65 15 Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. www.broad.mit.e...
Broad MANALO_HYPOXIA_DN View Gene Set 8.703e-66 276 1.301e-63 16 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN View Gene Set 3.154e-65 832 4.438e-63 17 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h. www.broad.mit.e...
Broad BENPORATH_MYC_MAX_TARGETS View Gene Set 2.198e-60 768 2.921e-58 18 Set 'Myc targets2': targets of c-Myc [Gene ID=4609] and Max [Gene ID=4149] identified by ChIP on chip in a Burkitt???s lymphoma cell line; overlap set. www.broad.mit.e...
Broad ACEVEDO_LIVER_CANCER_UP View Gene Set 1.521e-59 915 1.914e-57 19 Genes up-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples. www.broad.mit.e...
Broad RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN View Gene Set 1.687e-57 351 2.018e-55 20 Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. www.broad.mit.e...
Broad BORCZUK_MALIGNANT_MESOTHELIOMA_UP View Gene Set 9.968e-55 290 1.135e-52 21 Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma. www.broad.mit.e...
Broad BERENJENO_TRANSFORMED_BY_RHOA_UP View Gene Set 1.862e-54 485 2.024e-52 22 Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [Gene ID=387] off plasmid vector. www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_DN View Gene Set 2.669e-54 1209 2.775e-52 23 Genes down-regulated in brain from patients with Alzheimer's disease. www.broad.mit.e...
Broad BENPORATH_CYCLING_GENES View Gene Set 1.949e-53 630 1.942e-51 24 Genes showing cell-cycle stage-specific expression [PMID=12058064]. www.broad.mit.e...
Broad GARY_CD5_TARGETS_DN View Gene Set 2.977e-53 415 2.848e-51 25 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [Gene ID=921] off a plasmid vector. www.broad.mit.e...
Broad ZHANG_BREAST_CANCER_PROGENITORS_UP View Gene Set 3.51e-53 370 3.229e-51 26 Genes changed in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. www.broad.mit.e...
Broad HSIAO_HOUSEKEEPING_GENES View Gene Set 5.126e-53 384 4.541e-51 27 Housekeeping genes identified as expressed across 19 normal tissues. www.broad.mit.e...
Broad SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 View Gene Set 6.131e-53 435 5.238e-51 28 Cluster 6 of method A: up-regulation of these genes in patients with non???small cell lung cancer (NSCLC) predicts poor survival outcome. www.broad.mit.e...
Broad PUJANA_BRCA2_PCC_NETWORK View Gene Set 2.052e-52 410 1.692e-50 29 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA2 [Gene ID=675] across a compendium of normal tissues. www.broad.mit.e...
Broad GRADE_COLON_CANCER_UP View Gene Set 1.241e-51 711 9.891e-50 30 Up-regulated genes in colon carcinoma tumors compared to the matched normal mucosa samples. www.broad.mit.e...
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP View Gene Set 6.115e-50 469 4.719e-48 31 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. www.broad.mit.e...
Broad MOOTHA_MITOCHONDRIA View Gene Set 1.591e-48 433 1.189e-46 32 Mitochondrial genes www.broad.mit.e...
Broad SHEN_SMARCA2_TARGETS_UP View Gene Set 4.627e-48 406 3.354e-46 33 Genes whose expression positively correlated with that of SMARCA2 [Gene ID=6595] in prostate cancer samples. www.broad.mit.e...
Broad SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP View Gene Set 5.56e-48 143 3.912e-46 34 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. www.broad.mit.e...
Broad ENK_UV_RESPONSE_KERATINOCYTE_DN View Gene Set 6.287e-47 475 4.297e-45 35 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. www.broad.mit.e...
Broad MITSIADES_RESPONSE_TO_APLIDIN_DN View Gene Set 1.533e-46 241 1.018e-44 36 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164] a marine-derived compound with potential anti-cancer properties. www.broad.mit.e...
Broad HORIUCHI_WTAP_TARGETS_DN View Gene Set 3.224e-46 289 2.084e-44 37 Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. www.broad.mit.e...
Broad ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER View Gene Set 2.406e-45 138 1.514e-43 38 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. www.broad.mit.e...
Broad TARTE_PLASMA_CELL_VS_PLASMABLAST_DN View Gene Set 3.687e-45 303 2.261e-43 39 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. www.broad.mit.e...
Broad PUJANA_ATM_PCC_NETWORK View Gene Set 5.553e-45 1375 3.321e-43 40 Genes constituting the ATM-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of ATM [Gene ID=472] across a compendium of normal tissues. www.broad.mit.e...
Broad MOOTHA_HUMAN_MITODB_6_2002 View Gene Set 1.685e-44 420 9.83e-43 41 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. www.broad.mit.e...
Broad MILI_PSEUDOPODIA_HAPTOTAXIS_UP View Gene Set 3.042e-44 452 1.732e-42 42 Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin FN1 [Gene ID=2335]. www.broad.mit.e...
Broad KOBAYASHI_EGFR_SIGNALING_24HR_DN View Gene Set 6.678e-44 243 3.715e-42 43 Genes down-regulated in H1975 cells (non-small cell lung cancer NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. www.broad.mit.e...
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN View Gene Set 2.825e-43 571 1.536e-41 44 Genes down-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM View Gene Set 1.768e-42 154 9.398e-41 45 Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] and down-regulated by the combination of MYC and serum. www.broad.mit.e...
Broad FOURNIER_ACINAR_DEVELOPMENT_LATE_2 View Gene Set 3.597e-42 265 1.87e-40 46 Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. www.broad.mit.e...
Broad SCHLOSSER_SERUM_RESPONSE_DN View Gene Set 6.113e-41 666 3.105e-39 47 Cluster 4: genes down-regulated in B493-6 cells (B lymphocytes) upon serum stimulation but not affected by MYC [Gene ID=4609]. www.broad.mit.e...
Broad TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C View Gene Set 6.231e-41 436 3.105e-39 47 Genes down-regulated in HCT116 cells (colon cancer) upon expression of MIR34B or MIR34C [Gene ID=407041 407042] microRNAs. www.broad.mit.e...
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP View Gene Set 2.979e-39 184 1.454e-37 49 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3 defined by unsupervised clustering. www.broad.mit.e...
Broad MUELLER_PLURINET View Gene Set 5.225e-39 294 2.5e-37 50 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells embryonical carcinomas and induced pluripotent cells). www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_3_UP View Gene Set 2.844e-38 314 1.334e-36 51 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP View Gene Set 7.244e-38 681 3.332e-36 52 Genes up-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. www.broad.mit.e...
Broad BENPORATH_NANOG_TARGETS View Gene Set 8.937e-38 946 4.034e-36 53 Set 'Nanog targets': genes upregulated and identified by ChIP on chip as Nanog [Gene ID=79923] transcription factor targets in human embryonic stem cells. www.broad.mit.e...
Broad WONG_MITOCHONDRIA_GENE_MODULE View Gene Set 1.353e-37 208 5.992e-36 54 Genes that comprise the mitochondria gene module www.broad.mit.e...
Broad BIDUS_METASTASIS_UP View Gene Set 1.917e-37 203 8.338e-36 55 Genes up-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases. www.broad.mit.e...
Broad PUJANA_XPRSS_INT_NETWORK View Gene Set 1.162e-35 164 4.962e-34 56 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200] in a compendium of normal tissues. www.broad.mit.e...
Broad BLUM_RESPONSE_TO_SALIRASIB_DN View Gene Set 2.409e-35 332 1.011e-33 57 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. www.broad.mit.e...
Broad VECCHI_GASTRIC_CANCER_EARLY_UP View Gene Set 3.036e-35 408 1.252e-33 58 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. www.broad.mit.e...
Broad WINNEPENNINCKX_MELANOMA_METASTASIS_UP View Gene Set 3.649e-35 152 1.479e-33 59 Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years. www.broad.mit.e...
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP View Gene Set 4.457e-35 532 1.777e-33 60 Genes diffierentially expressed in kidney biopsies from patients with well functioning kidneys more than 1-year post transplant compared to the biopsies from normal living kidney donors. www.broad.mit.e...
Broad STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN View Gene Set 2.295e-34 437 9e-33 61 Genes down-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region. www.broad.mit.e...
Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN View Gene Set 6.213e-34 599 2.397e-32 62 Genes down-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. www.broad.mit.e...
Broad DANG_MYC_TARGETS_UP View Gene Set 2.214e-33 127 8.406e-32 63 Genes up-regulated by MYC [Gene ID=4609] and whose promoters are bound by MYC according to MYC Target Gene Database. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 View Gene Set 4.225e-32 165 1.579e-30 64 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_DN View Gene Set 1.584e-30 825 5.831e-29 65 Genes down-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. www.broad.mit.e...
Broad BENPORATH_PROLIFERATION View Gene Set 1.722e-30 140 6.241e-29 66 Set 'Proliferation Cluster': genes defined in human breast tumor expression data. www.broad.mit.e...
Broad LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN View Gene Set 2.922e-30 742 1.043e-28 67 Genes with copy number losses in primary neuroblastoma tumors. www.broad.mit.e...
Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN View Gene Set 1.2e-29 155 4.222e-28 68 Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. www.broad.mit.e...
Broad RAMALHO_STEMNESS_UP View Gene Set 1.31e-29 192 4.542e-28 69 Genes enriched in embryonic neural and hematopoietic stem cells. www.broad.mit.e...
Broad BENPORATH_SOX2_TARGETS View Gene Set 1.902e-29 704 6.5e-28 70 Set 'Sox2 targets': genes upregulated and identified by ChIP on chip as SOX2 [Gene ID=6657] transcription factor targets in human embryonic stem cells. www.broad.mit.e...
Broad LOPEZ_MBD_TARGETS View Gene Set 4.518e-29 855 1.522e-27 71 Genes up-regulated in HeLa cells (cervical cancer) after simultaneus knockdown of all three MBD (methyl-CpG binding domain) proteins MeCP2 MBD1 and MBD2 [Gene ID=4204 4152 8932] by RNAi. www.broad.mit.e...
Broad NUYTTEN_NIPP1_TARGETS_DN View Gene Set 2.496e-28 758 8.291e-27 72 Genes down-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. www.broad.mit.e...
Broad WEST_ADRENOCORTICAL_TUMOR_UP View Gene Set 3.54e-28 283 1.16e-26 73 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. www.broad.mit.e...
Broad GRADE_COLON_AND_RECTAL_CANCER_UP View Gene Set 5.119e-28 213 1.655e-26 74 Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. www.broad.mit.e...
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP View Gene Set 1.227e-27 180 3.913e-26 75 Genes up-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. www.broad.mit.e...
Broad KIM_WT1_TARGETS_DN View Gene Set 4.461e-27 431 1.404e-25 76 Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [Gene ID=7490]. www.broad.mit.e...
Broad MARKEY_RB1_ACUTE_LOF_DN View Gene Set 9.875e-27 201 3.068e-25 77 Genes down-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. www.broad.mit.e...
Broad GEORGES_TARGETS_OF_MIR192_AND_MIR215 View Gene Set 1.491e-26 809 4.572e-25 78 Genes down-regulated in HCT116 cells (colon cancer) by expression of MIR192 or MIR215 [Gene ID=406967 406997] at 24 h. www.broad.mit.e...
Broad MOHANKUMAR_TLX1_TARGETS_UP View Gene Set 1.866e-26 388 5.649e-25 79 Up-regulated in MCF7 cells (breast cancer) by TLX1 (HOX11) [Gene ID=3195]. www.broad.mit.e...
Broad CROONQUIST_IL6_DEPRIVATION_DN View Gene Set 2.432e-26 80 7.27e-25 80 Genes down-regulated in the ANBL-6 cell line (multiple myeloma MM) after withdrawal of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN View Gene Set 5.951e-26 532 1.757e-24 81 Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. www.broad.mit.e...
Broad WELCSH_BRCA1_TARGETS_1_DN View Gene Set 1.711e-25 124 4.991e-24 82 Upregulated by induction of exogenous BRCA1 in EcR-293 cells www.broad.mit.e...
Broad LIU_SOX4_TARGETS_DN View Gene Set 2.535e-25 297 7.307e-24 83 Genes down-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [Gene ID=6659] and up-regulated by its RNAi knockdown. www.broad.mit.e...
Broad WHITEFORD_PEDIATRIC_CANCER_MARKERS View Gene Set 4.398e-25 92 1.252e-23 84 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. www.broad.mit.e...
Broad PAL_PRMT5_TARGETS_UP View Gene Set 4.672e-25 178 1.315e-23 85 Genes up-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [Gene ID=10419] by RNAi. www.broad.mit.e...
Broad MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN View Gene Set 1.267e-24 212 3.523e-23 86 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 View Gene Set 2.603e-24 158 7.158e-23 87 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13. www.broad.mit.e...
Broad PUJANA_BRCA_CENTERED_NETWORK View Gene Set 2.762e-24 92 7.509e-23 88 Genes constituting the BRCA-centered network (BCN). www.broad.mit.e...
Broad BASAKI_YBX1_TARGETS_UP View Gene Set 1.161e-23 279 3.121e-22 89 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [Gene ID=4904] knockdown by RNAi. www.broad.mit.e...
Broad KANG_DOXORUBICIN_RESISTANCE_UP View Gene Set 1.585e-23 53 4.212e-22 90 Genes differentialy expressed in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive. www.broad.mit.e...
Broad OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP View Gene Set 1.859e-23 114 4.887e-22 91 Genes up-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors. www.broad.mit.e...
Broad MOOTHA_PGC View Gene Set 2.151e-23 329 5.592e-22 92 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [Gene ID=10891] off an adenoviral vector. www.broad.mit.e...
Broad UDAYAKUMAR_MED1_TARGETS_UP View Gene Set 3.337e-23 129 8.584e-22 93 Genes up-regulated in HeLa cells after knockdown of MED1 [Gene ID=5469] by RNAi. www.broad.mit.e...
Broad LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN View Gene Set 1.155e-22 158 2.94e-21 94 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. www.broad.mit.e...
Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP View Gene Set 1.23e-22 359 3.098e-21 95 The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. www.broad.mit.e...
Broad BENPORATH_ES_1 View Gene Set 1.301e-22 367 3.241e-21 96 Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies. www.broad.mit.e...
Broad FUJII_YBX1_TARGETS_DN View Gene Set 2.422e-22 139 5.972e-21 97 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [Gene ID=4904] by RNAi. www.broad.mit.e...
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_DN View Gene Set 4.279e-22 96 1.044e-20 98 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668] a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. www.broad.mit.e...
Broad MILI_PSEUDOPODIA_HAPTOTAXIS_DN View Gene Set 1.034e-21 607 2.497e-20 99 Transcripts depleted from pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin FN1 [Gene ID=2335]. www.broad.mit.e...
Broad LEE_LIVER_CANCER_SURVIVAL_DN View Gene Set 1.314e-21 123 3.143e-20 100 Genes highly expressed in hepatocellular carcinoma with poor survival. www.broad.mit.e...
Broad ONKEN_UVEAL_MELANOMA_UP View Gene Set 1.78e-21 739 4.216e-20 101 Genes up-regulated in uveal melanoma: class 2 vs class 1 tumors. www.broad.mit.e...
Broad DAIRKEE_TERT_TARGETS_UP View Gene Set 2.562e-21 317 6.009e-20 102 Genes up-regulated in non-spontaneously immortalizing (NSI) primary breast cancer tumor cultures upon expression of TERT [Gene ID=7015] off a retroviral vector. www.broad.mit.e...
Broad GOLDRATH_HOMEOSTATIC_PROLIFERATION View Gene Set 2.859e-21 154 6.639e-20 103 Up-regulated in CD8+ [Gene ID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population. www.broad.mit.e...
Broad WANG_LMO4_TARGETS_UP View Gene Set 5.336e-21 341 1.227e-19 104 Genes up-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [Gene ID=8543] by a Tet Off system. www.broad.mit.e...
Broad CROONQUIST_NRAS_SIGNALING_DN View Gene Set 7.867e-21 62 1.792e-19 105 Genes down-regulated in ANBL-6 cell line (multiple myeloma MM) expressing a constantly active form of NRAS [Gene ID=4893] off a plasmid vector compared to those grown in the presence of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER View Gene Set 1.083e-20 167 2.444e-19 106 Overexpressed genes with amplified copy number across 27 non-small cell lung cancer (NSCLC) cell lines. www.broad.mit.e...
Broad PENG_GLUTAMINE_DEPRIVATION_DN View Gene Set 1.998e-20 84 4.466e-19 107 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. www.broad.mit.e...
Broad HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP View Gene Set 3.791e-20 93 8.397e-19 108 Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte. www.broad.mit.e...
Broad SCHUHMACHER_MYC_TARGETS_UP View Gene Set 5.365e-20 68 1.177e-18 109 Genes up-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [Gene ID=4609]. www.broad.mit.e...
Broad ELVIDGE_HYPOXIA_DN View Gene Set 7.392e-20 136 1.607e-18 110 Genes down-regulated in MCF7 cells (breast cancer) under hypoxia conditions. www.broad.mit.e...
Broad WANG_SMARCE1_TARGETS_DN View Gene Set 8.587e-20 329 1.85e-18 111 Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [Gene ID=6605] off a retroviral vector. www.broad.mit.e...
Broad OSMAN_BLADDER_CANCER_UP View Gene Set 9.634e-20 387 2.057e-18 112 Genes up-regulated in blood samples from bladder cancer patients. www.broad.mit.e...
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN View Gene Set 1.084e-19 86 2.296e-18 113 Genes down-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 View Gene Set 5.168e-19 63 1.084e-17 114 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. www.broad.mit.e...
Broad NELSON_RESPONSE_TO_ANDROGEN_UP View Gene Set 5.651e-19 81 1.175e-17 115 Genes up-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766]. www.broad.mit.e...
Broad STEIN_ESRRA_TARGETS View Gene Set 7.963e-19 508 1.642e-17 116 Genes regulated by ESRRA [Gene ID=2101] in MCF-7 cells (breast cancer). www.broad.mit.e...
Broad MORI_LARGE_PRE_BII_LYMPHOCYTE_UP View Gene Set 4.63e-18 52 9.466e-17 117 Up-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 View Gene Set 6.329e-18 131 1.283e-16 118 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 14. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_24HR_DN View Gene Set 7.862e-18 208 1.58e-16 119 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN View Gene Set 8.5e-18 418 1.694e-16 120 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [Gene ID=2071] after UVC irradiation. www.broad.mit.e...
Broad ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN View Gene Set 1.122e-17 346 2.219e-16 121 Genes down-regulated in normal tissue adjacent to liver tumor compared to the normal liver samples. www.broad.mit.e...
Broad RHODES_CANCER_META_SIGNATURE View Gene Set 1.966e-17 54 3.854e-16 122 Genes commonly up-regulated in cancer relative to normal tissue according to the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad ZHAN_MULTIPLE_MYELOMA_PR_UP View Gene Set 3.539e-17 43 6.883e-16 123 Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_UP View Gene Set 6.437e-17 1641 1.242e-15 124 Genes up-regulated in brain from patients with Alzheimer's disease. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN View Gene Set 1.753e-16 46 3.355e-15 125 Cluster 6: genes down-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] in combination with serum but not affected by serum alone; they are also up-regulated by MYC alone. www.broad.mit.e...
Broad ONKEN_UVEAL_MELANOMA_DN View Gene Set 2.162e-16 509 4.104e-15 126 Genes down-regulated in uveal melanoma: class 2 vs class 1 tumors. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP View Gene Set 3.719e-16 45 7.004e-15 127 Cluster 5: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] alone or in combination with serum but not by serum alone. www.broad.mit.e...
Broad MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN View Gene Set 4.668e-16 121 8.724e-15 128 Genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [Gene ID=23495]. www.broad.mit.e...
Broad STEIN_ESRRA_TARGETS_UP View Gene Set 7.679e-16 368 1.424e-14 129 Genes up-regulated by ESRRA [Gene ID=2101] only. www.broad.mit.e...
Broad LI_AMPLIFIED_IN_LUNG_CANCER View Gene Set 9.576e-16 165 1.762e-14 130 Genes with increased copy number that correlates with increased expression across six different lung adenocarcinoma cell lines. www.broad.mit.e...
Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP View Gene Set 1.254e-15 135 2.291e-14 131 Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation high levels of serum AFP [Gene ID=174] and chromosomal instability. www.broad.mit.e...
Broad IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR View Gene Set 1.337e-15 100 2.423e-14 132 Genes in the expression cluster 'Early Progenitors Shared': up-regulated in hematopoietic progenitors from adult bone marrow and from fetal liver. www.broad.mit.e...
Broad RHODES_UNDIFFERENTIATED_CANCER View Gene Set 1.408e-15 60 2.533e-14 133 Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer based on the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad REN_BOUND_BY_E2F View Gene Set 1.489e-15 47 2.659e-14 134 Genes whose promoters were bound by E2F1 [Gene ID=1869] and E2F4 [Gene ID=1874] in the primary fibroblasts WI-38 by ChIP on chip assay. www.broad.mit.e...
Broad WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP View Gene Set 1.745e-15 244 3.091e-14 135 Genes up-regulated in mucinous ovarian carcinoma tumors of low malignant potential (LMP) compared to normal ovarian surface epithelium tissue. www.broad.mit.e...
Broad HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN View Gene Set 1.981e-15 111 3.472e-14 136 Genes down-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP View Gene Set 1.989e-15 53 3.472e-14 136 The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [Gene ID=672] compared to those with the wild type allele. www.broad.mit.e...
Broad CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP View Gene Set 2.208e-15 135 3.828e-14 138 Genes up-regulated in CD4+ [Gene ID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360]. www.broad.mit.e...
Broad CHANG_CYCLING_GENES View Gene Set 2.803e-15 49 4.824e-14 139 Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. www.broad.mit.e...
Broad MOOTHA_VOXPHOS View Gene Set 3.303e-15 82 5.643e-14 140 Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. www.broad.mit.e...
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 View Gene Set 4.441e-15 491 7.534e-14 141 The 'group 1 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099 2064]. www.broad.mit.e...
Broad GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN View Gene Set 5.179e-15 148 8.724e-14 142 Genes down-regulated in the A673 cells (Ewing sarcoma) after double knockdown of both FLI1 and DAX1 [Gene ID=2313 190] by RNAi. www.broad.mit.e...
Broad FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP View Gene Set 5.221e-15 147 8.734e-14 143 Genes upreglated in peripheral blood lymphocytes (PBL) from patients with well functioning kidneys more than 1-year post transplant compared to those from normal living kidney donors. www.broad.mit.e...
Broad LIU_PROSTATE_CANCER_UP View Gene Set 5.323e-15 88 8.842e-14 144 Genes up-regulated in prostate cancer samples. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_LIT_INT_NETWORK View Gene Set 8.154e-15 100 1.345e-13 145 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200]; the interactions were manually curated from the literature. www.broad.mit.e...
Broad AMUNDSON_GAMMA_RADIATION_RESPONSE View Gene Set 8.447e-15 36 1.384e-13 146 Genes down-regulated across the entire panel of NCI-60 cell lines in response to gamma radiation. www.broad.mit.e...
Broad ODONNELL_TFRC_TARGETS_DN View Gene Set 1.002e-14 131 1.63e-13 147 Genes dpwn-regulated in P493-6 cells (B lymphocyte) upon knockdown of TFRC [Gene ID=7037] by RNAi. www.broad.mit.e...
Broad SEIDEN_ONCOGENESIS_BY_MET View Gene Set 1.014e-14 83 1.638e-13 148 Genes changed in xenograft tumors formed by DLD-1 or DKO-4 cells (colon cancer) overexpressing MET [Gene ID=4233]. www.broad.mit.e...
Broad VANTVEER_BREAST_CANCER_METASTASIS_DN View Gene Set 1.252e-14 104 2.009e-13 149 Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). www.broad.mit.e...
Broad KAUFFMANN_MELANOMA_RELAPSE_UP View Gene Set 1.801e-14 57 2.873e-13 150 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. www.broad.mit.e...
Broad HAMAI_APOPTOSIS_VIA_TRAIL_UP View Gene Set 2.333e-14 328 3.695e-13 151 Genes up-regulated in T1 cells (primary melanoma sensitive to TRAIL [Gene ID=8743]) compared to G1 cells (metastatic melanoma resistant to TRAIL). www.broad.mit.e...
Broad FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN View Gene Set 2.391e-14 43 3.762e-13 152 Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen raloxifene or ICI 182780 but not by estradiol [PubChem=44959 5035 3478439 5757]. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPLICATION_GENES View Gene Set 2.591e-14 128 4.05e-13 153 Genes involved in DNA replication compiled manually by the authors. www.broad.mit.e...
Broad BASSO_B_LYMPHOCYTE_NETWORK View Gene Set 3.098e-14 136 4.812e-13 154 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. www.broad.mit.e...
Broad MORI_IMMATURE_B_LYMPHOCYTE_DN View Gene Set 3.18e-14 52 4.908e-13 155 Down-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the immature B stage. www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_UP View Gene Set 3.454e-14 301 5.296e-13 156 Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. www.broad.mit.e...
Broad FARMER_BREAST_CANCER_CLUSTER_2 View Gene Set 4.114e-14 33 6.268e-13 157 Cluster 2: selected proliferation and 8q amplicon genes clustered together across breast cancer samples. www.broad.mit.e...
Broad FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP View Gene Set 1.07e-13 144 1.619e-12 158 Genes up-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones. www.broad.mit.e...
Broad YU_MYC_TARGETS_UP View Gene Set 1.294e-13 37 1.947e-12 159 Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [Gene ID=4609]. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 View Gene Set 1.589e-13 93 2.375e-12 160 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. www.broad.mit.e...
Broad GOLDRATH_ANTIGEN_RESPONSE View Gene Set 1.603e-13 315 2.382e-12 161 Genes up-regulated at the peak of an antigen response of naive CD8+ [Gene ID=925 926] T-cells. www.broad.mit.e...
Broad CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP View Gene Set 1.922e-13 51 2.839e-12 162 Protein biosynthesis transport or catabolism genes up-regulated in hyperploid multiple myeloma (MM) compared to the non-hyperploid MM samples. www.broad.mit.e...
Broad JISON_SICKLE_CELL_DISEASE_DN View Gene Set 2.187e-13 168 3.21e-12 163 Genes down-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects. www.broad.mit.e...
Broad SONG_TARGETS_OF_IE86_CMV_PROTEIN View Gene Set 2.247e-13 49 3.278e-12 164 Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector. www.broad.mit.e...
Broad ZHANG_RESPONSE_TO_CANTHARIDIN_DN View Gene Set 2.997e-13 60 4.345e-12 165 Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. www.broad.mit.e...
Broad BLUM_RESPONSE_TO_SALIRASIB_UP View Gene Set 3.245e-13 240 4.675e-12 166 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. www.broad.mit.e...
Broad DAZARD_RESPONSE_TO_UV_NHEK_DN View Gene Set 3.926e-13 256 5.623e-12 167 Genes down-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. www.broad.mit.e...
Broad HOSHIDA_LIVER_CANCER_SUBCLASS_S2 View Gene Set 5.105e-13 114 7.269e-12 168 Genes from 'subtype S2' signature of hepatocellular carcinoma (HCC): proliferation MYC and AKT1 [Gene ID=4609 207] activation. www.broad.mit.e...
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP View Gene Set 5.421e-13 422 7.672e-12 169 Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPAIR_GENES View Gene Set 7.175e-13 205 1.01e-11 170 Genes involved in DNA repair compiled manually by the authors. www.broad.mit.e...
Broad BENPORATH_MYC_TARGETS_WITH_EBOX View Gene Set 8.441e-13 229 1.181e-11 171 Set 'Myc targets1': targets of c-Myc [Gene ID=4609] identified by ChIP on chip in cultured cell lines focusing on E-box???containing genes; high affinity bound subset www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_6HR_UP View Gene Set 1.088e-12 50 1.513e-11 172 Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 6h. www.broad.mit.e...
Broad ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN View Gene Set 1.356e-12 61 1.875e-11 173 Genes down-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562]. www.broad.mit.e...
Broad SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN View Gene Set 1.388e-12 79 1.909e-11 174 Selected genes down-regulated in inflammatory monocytes infiltrating hepatocellular carcinoma (HCC). www.broad.mit.e...
Broad ALONSO_METASTASIS_UP View Gene Set 1.442e-12 152 1.972e-11 175 Up-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not. www.broad.mit.e...
Broad CAIRO_HEPATOBLASTOMA_UP View Gene Set 1.503e-12 200 2.043e-11 176 Genes up-regulated in hepatoblastoma samples compared to normal liver tissue. www.broad.mit.e...
Broad MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN View Gene Set 2.125e-12 42 2.871e-11 177 Genes down-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI [Gene ID=23495]. www.broad.mit.e...
Broad KIM_WT1_TARGETS_12HR_DN View Gene Set 2.212e-12 200 2.972e-11 178 Genes down-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [Gene ID=7490]. www.broad.mit.e...
Broad KAAB_FAILED_HEART_ATRIUM_DN View Gene Set 2.244e-12 139 2.999e-11 179 Genes down-regulated in atria of failing hearts (DCM and ICM) compared to healthy controls. www.broad.mit.e...
Broad WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP View Gene Set 2.525e-12 131 3.356e-11 180 Genes up-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue. www.broad.mit.e...
Broad LE_EGR2_TARGETS_UP View Gene Set 2.836e-12 100 3.748e-11 181 Genes up-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [Gene ID=1959]. www.broad.mit.e...
Broad SWEET_LUNG_CANCER_KRAS_UP View Gene Set 2.915e-12 436 3.832e-11 182 Genes up-regulated in the mouse lung cancer model with mutated KRAS [Gene ID=3845]. www.broad.mit.e...
Broad DITTMER_PTHLH_TARGETS_UP View Gene Set 3.273e-12 108 4.278e-11 183 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [Gene ID=5744] by RNAi. www.broad.mit.e...
Broad ELVIDGE_HIF1A_TARGETS_UP View Gene Set 3.32e-12 64 4.316e-11 184 Genes up-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [Gene ID=3091] by RNAi. www.broad.mit.e...
Broad NAKAMURA_CANCER_MICROENVIRONMENT_DN View Gene Set 4.654e-12 45 6.017e-11 185 Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. www.broad.mit.e...
Broad MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN View Gene Set 7.717e-12 53 9.924e-11 186 Genes commonly down-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [Gene ID=595 1019]. www.broad.mit.e...
Broad POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN View Gene Set 9.661e-12 39 1.236e-10 187 Top marker genes in medulloblastoma associated with poor response to treatment (poor outcome). www.broad.mit.e...
Broad LY_AGING_OLD_DN View Gene Set 9.716e-12 47 1.236e-10 188 Genes up-regulated in fibroblasts from old individuals compared to those from young donors. www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_1_DN View Gene Set 1.002e-11 368 1.268e-10 189 Genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. www.broad.mit.e...
Broad LEE_EARLY_T_LYMPHOCYTE_UP View Gene Set 1.009e-11 80 1.27e-10 190 Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. www.broad.mit.e...
Broad FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN View Gene Set 1.053e-11 76 1.318e-10 191 Top 100 genes positively (UP) and negatively (DN) associated with T-cell acute lymphoblastic leukemia MLL T-ALL) expressing MLL-ENL fusion [Gene ID=4297 4298]. www.broad.mit.e...
Broad WANG_LMO4_TARGETS_DN View Gene Set 1.147e-11 327 1.429e-10 192 Genes down-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [Gene ID=8543] by a Tet Off system. www.broad.mit.e...
Broad PENG_RAPAMYCIN_RESPONSE_DN View Gene Set 1.174e-11 69 1.455e-10 193 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. www.broad.mit.e...
Broad FARMER_BREAST_CANCER_APOCRINE_VS_BASAL View Gene Set 2.113e-11 321 2.605e-10 194 Genes which best discriminate between two groups of breast cancer according the status of ESR1 and AR [Gene ID=2099 367]: apocrine (ESR1- AR+) vs basal (ESR1- AR-). www.broad.mit.e...
Broad GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN View Gene Set 2.146e-11 51 2.632e-10 195 Genes from the turquoise module which are down-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphocholine (oxPAPC). www.broad.mit.e...
Broad LANDIS_ERBB2_BREAST_TUMORS_324_UP View Gene Set 2.178e-11 132 2.659e-10 196 The 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [Gene ID=2064]. www.broad.mit.e...
Broad WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP View Gene Set 2.508e-11 99 3.046e-10 197 Genes up-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders). www.broad.mit.e...
Broad AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP View Gene Set 2.963e-11 288 3.58e-10 198 Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens. www.broad.mit.e...
Broad WELCSH_BRCA1_TARGETS_1_UP View Gene Set 4.503e-11 171 5.413e-10 199 Upregulated by induction of exogenous BRCA1 in EcR-293 cells www.broad.mit.e...
Broad ROME_INSULIN_TARGETS_IN_MUSCLE_UP View Gene Set 5.599e-11 89 6.696e-10 200 Genes up-regulated by 3 h of euglycemic hyperinsulinemic clamp in the vastus lateralis muscle of healthy lean subjects. www.broad.mit.e...

Gene Set Collection: Broad.c2.CP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES View Gene Set 2.86e-05 49 0.001344 1 Genes related to the insulin receptor pathway www.broad.mit.e...
Broad SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES View Gene Set 0.000444 63 0.01043 2 Genes related to PIP3 signaling in cardiac myocytes www.broad.mit.e...
Broad SA_PTEN_PATHWAY View Gene Set 0.001031 16 0.01616 3 PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. www.broad.mit.e...
Broad SA_G1_AND_S_PHASES View Gene Set 0.00195 15 0.02292 4 Cdk2 4 and 6 bind cyclin D in G1 while cdk2/cyclin E promotes the G1/S transition. www.broad.mit.e...
Broad ST_GA13_PATHWAY View Gene Set 0.003416 35 0.02676 5 G alpha 13 Pathway www.broad.mit.e...
Broad SA_REG_CASCADE_OF_CYCLIN_EXPR View Gene Set 0.002964 13 0.02676 5 Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. www.broad.mit.e...
Broad SIG_CHEMOTAXIS View Gene Set 0.008468 44 0.04539 7 Genes related to chemotaxis www.broad.mit.e...
Broad ST_P38_MAPK_PATHWAY View Gene Set 0.008692 35 0.04539 7 p38 MAPK Pathway www.broad.mit.e...
Broad ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY View Gene Set 0.007254 34 0.04539 7 PI3K Pathway www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.BIOCARTA

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad BIOCARTA_EIF_PATHWAY View Gene Set 6.968e-07 16 7.055e-05 1 Eukaryotic protein translation www.broad.mit.e...
Broad BIOCARTA_RACCYCD_PATHWAY View Gene Set 9.491e-07 26 7.055e-05 1 Influence of Ras and Rho proteins on G1 to S Transition www.broad.mit.e...
Broad BIOCARTA_RANMS_PATHWAY View Gene Set 9.754e-07 10 7.055e-05 1 Role of Ran in mitotic spindle regulation www.broad.mit.e...
Broad BIOCARTA_P27_PATHWAY View Gene Set 2.163e-06 13 0.0001174 4 Regulation of p27 Phosphorylation during Cell Cycle Progression www.broad.mit.e...
Broad BIOCARTA_AKAP95_PATHWAY View Gene Set 3.291e-06 12 0.0001428 5 AKAP95 role in mitosis and chromosome dynamics www.broad.mit.e...
Broad BIOCARTA_MTOR_PATHWAY View Gene Set 4.443e-06 23 0.0001607 6 mTOR Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_PROTEASOME_PATHWAY View Gene Set 5.508e-06 19 0.0001707 7 Proteasome Complex www.broad.mit.e...
Broad BIOCARTA_IGF1R_PATHWAY View Gene Set 5.03e-05 23 0.001092 8 Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation www.broad.mit.e...
Broad BIOCARTA_RAS_PATHWAY View Gene Set 4.474e-05 23 0.001092 8 Ras Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_IGF1MTOR_PATHWAY View Gene Set 4.541e-05 20 0.001092 8 Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway www.broad.mit.e...
Broad BIOCARTA_AKAPCENTROSOME_PATHWAY View Gene Set 0.0001492 15 0.002699 11 Protein Kinase A at the Centrosome www.broad.mit.e...
Broad BIOCARTA_EIF4_PATHWAY View Gene Set 0.0001469 24 0.002699 11 Regulation of eIF4e and p70 S6 Kinase www.broad.mit.e...
Broad BIOCARTA_SRCRPTP_PATHWAY View Gene Set 0.0002016 11 0.003005 13 Activation of Src by Protein-tyrosine phosphatase alpha www.broad.mit.e...
Broad BIOCARTA_RB_PATHWAY View Gene Set 0.000182 13 0.003005 13 RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage www.broad.mit.e...
Broad BIOCARTA_ATRBRCA_PATHWAY View Gene Set 0.0002187 21 0.003005 13 Role of BRCA1 BRCA2 and ATR in Cancer Susceptibility www.broad.mit.e...
Broad BIOCARTA_CDC42RAC_PATHWAY View Gene Set 0.0002216 16 0.003005 13 Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration www.broad.mit.e...
Broad BIOCARTA_EIF2_PATHWAY View Gene Set 0.0002449 11 0.003126 17 Regulation of eIF2 www.broad.mit.e...
Broad BIOCARTA_G1_PATHWAY View Gene Set 0.0002657 28 0.003203 18 Cell Cycle: G1/S Check Point www.broad.mit.e...
Broad BIOCARTA_MCM_PATHWAY View Gene Set 0.0003187 18 0.00364 19 CDK Regulation of DNA Replication www.broad.mit.e...
Broad BIOCARTA_VDR_PATHWAY View Gene Set 0.000504 12 0.005469 20 Control of Gene Expression by Vitamin D Receptor www.broad.mit.e...
Broad BIOCARTA_CELLCYCLE_PATHWAY View Gene Set 0.0006038 23 0.005859 21 Cyclins and Cell Cycle Regulation www.broad.mit.e...
Broad BIOCARTA_HCMV_PATHWAY View Gene Set 0.000648 17 0.005859 21 Human Cytomegalovirus and Map Kinase Pathways www.broad.mit.e...
Broad BIOCARTA_CHREBP2_PATHWAY View Gene Set 0.0005817 42 0.005859 21 Regulation And Function Of ChREBP in Liver www.broad.mit.e...
Broad BIOCARTA_WNT_PATHWAY View Gene Set 0.0006233 26 0.005859 21 WNT Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_ARF_PATHWAY View Gene Set 0.0008349 17 0.007247 25 Tumor Suppressor Arf Inhibits Ribosomal Biogenesis www.broad.mit.e...
Broad BIOCARTA_PPARA_PATHWAY View Gene Set 0.0009401 58 0.007846 26 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) www.broad.mit.e...
Broad BIOCARTA_CERAMIDE_PATHWAY View Gene Set 0.001056 22 0.008488 27 Ceramide Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_ETC_PATHWAY View Gene Set 0.001155 12 0.008955 28 Electron Transport Reaction in Mitochondria www.broad.mit.e...
Broad BIOCARTA_CREB_PATHWAY View Gene Set 0.001223 27 0.009149 29 Transcription factor CREB and its extracellular signals www.broad.mit.e...
Broad BIOCARTA_KREB_PATHWAY View Gene Set 0.001484 8 0.01073 30 The Citric Acid Cycle www.broad.mit.e...
Broad BIOCARTA_TFF_PATHWAY View Gene Set 0.001582 21 0.01107 31 Trefoil Factors Initiate Mucosal Healing www.broad.mit.e...
Broad BIOCARTA_EDG1_PATHWAY View Gene Set 0.001633 27 0.01107 32 Phospholipids as signalling intermediaries www.broad.mit.e...
Broad BIOCARTA_G2_PATHWAY View Gene Set 0.001916 24 0.0126 33 Cell Cycle: G2/M Checkpoint www.broad.mit.e...
Broad BIOCARTA_MPR_PATHWAY View Gene Set 0.001989 34 0.0127 34 How Progesterone Initiates Oocyte Membrane www.broad.mit.e...
Broad BIOCARTA_SKP2E2F_PATHWAY View Gene Set 0.002178 10 0.0135 35 E2F1 Destruction Pathway www.broad.mit.e...
Broad BIOCARTA_RNA_PATHWAY View Gene Set 0.002869 10 0.0173 36 Double Stranded RNA Induced Gene Expression www.broad.mit.e...
Broad BIOCARTA_VIP_PATHWAY View Gene Set 0.00374 27 0.0216 37 Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells www.broad.mit.e...
Broad BIOCARTA_RAB_PATHWAY View Gene Set 0.003783 12 0.0216 37 Rab GTPases Mark Targets In The Endocytotic Machinery www.broad.mit.e...
Broad BIOCARTA_MAPK_PATHWAY View Gene Set 0.00444 87 0.0247 39 MAPKinase Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_RHO_PATHWAY View Gene Set 0.004702 32 0.02551 40 Rho cell motility signaling pathway www.broad.mit.e...
Broad BIOCARTA_ECM_PATHWAY View Gene Set 0.005035 24 0.02665 41 Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia www.broad.mit.e...
Broad BIOCARTA_FMLP_PATHWAY View Gene Set 0.005265 37 0.02677 42 fMLP induced chemokine gene expression in HMC-1 cells www.broad.mit.e...
Broad BIOCARTA_ACTINY_PATHWAY View Gene Set 0.005304 20 0.02677 42 Y branching of actin filaments www.broad.mit.e...
Broad BIOCARTA_GLYCOLYSIS_PATHWAY View Gene Set 0.00642 10 0.03166 44 Glycolysis Pathway www.broad.mit.e...
Broad BIOCARTA_HIVNEF_PATHWAY View Gene Set 0.006597 58 0.03181 45 HIV-I Nef: negative effector of Fas and TNF www.broad.mit.e...
Broad BIOCARTA_GSK3_PATHWAY View Gene Set 0.007285 27 0.03364 46 Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages www.broad.mit.e...
Broad BIOCARTA_GPCR_PATHWAY View Gene Set 0.007163 35 0.03364 46 Signaling Pathway from G-Protein Families www.broad.mit.e...
Broad BIOCARTA_BCELLSURVIVAL_PATHWAY View Gene Set 0.007608 16 0.03439 48 B Cell Survival Pathway www.broad.mit.e...
Broad BIOCARTA_DNAFRAGMENT_PATHWAY View Gene Set 0.007829 10 0.03467 49 Apoptotic DNA fragmentation and tissue homeostasis www.broad.mit.e...
Broad BIOCARTA_CHEMICAL_PATHWAY View Gene Set 0.008064 22 0.035 50 Apoptotic Signaling in Response to DNA Damage www.broad.mit.e...
Broad BIOCARTA_PYK2_PATHWAY View Gene Set 0.00911 29 0.03876 51 Links between Pyk2 and Map Kinases www.broad.mit.e...
Broad BIOCARTA_NFKB_PATHWAY View Gene Set 0.009642 23 0.04024 52 NF-kB Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_CXCR4_PATHWAY View Gene Set 0.01018 24 0.04169 53 CXCR4 Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_SALMONELLA_PATHWAY View Gene Set 0.01087 13 0.04233 54 How does salmonella hijack a cell www.broad.mit.e...
Broad BIOCARTA_AKAP13_PATHWAY View Gene Set 0.01092 12 0.04233 54 Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation www.broad.mit.e...
Broad BIOCARTA_HER2_PATHWAY View Gene Set 0.01066 22 0.04233 54 Role of ERBB2 in Signal Transduction and Oncology www.broad.mit.e...
Broad BIOCARTA_PTC1_PATHWAY View Gene Set 0.0114 11 0.04339 57 Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle www.broad.mit.e...
Broad BIOCARTA_CK1_PATHWAY View Gene Set 0.01306 17 0.04886 58 Regulation of ck1/cdk5 by type 1 glutamate receptors www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad KEGG_RIBOSOME View Gene Set 3.772e-21 88 7.015e-19 1 Ribosome www.broad.mit.e...
Broad KEGG_SPLICEOSOME View Gene Set 3.638e-19 118 3.384e-17 2 Spliceosome www.broad.mit.e...
Broad KEGG_CELL_CYCLE View Gene Set 1.909e-16 128 1.183e-14 3 Cell cycle www.broad.mit.e...
Broad KEGG_HUNTINGTONS_DISEASE View Gene Set 1.51e-12 185 7.02e-11 4 Huntington's disease www.broad.mit.e...
Broad KEGG_PYRIMIDINE_METABOLISM View Gene Set 9.337e-12 98 2.894e-10 5 Pyrimidine metabolism www.broad.mit.e...
Broad KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS View Gene Set 7.845e-12 138 2.894e-10 5 Ubiquitin mediated proteolysis www.broad.mit.e...
Broad KEGG_OXIDATIVE_PHOSPHORYLATION View Gene Set 1.132e-11 135 3.007e-10 7 Oxidative phosphorylation www.broad.mit.e...
Broad KEGG_PARKINSONS_DISEASE View Gene Set 7.698e-11 133 1.79e-09 8 Parkinson's disease www.broad.mit.e...
Broad KEGG_RNA_DEGRADATION View Gene Set 2.226e-10 59 4.6e-09 9 RNA degradation www.broad.mit.e...
Broad KEGG_ALZHEIMERS_DISEASE View Gene Set 1.65e-09 169 3.068e-08 10 Alzheimer's disease www.broad.mit.e...
Broad KEGG_AMINOACYL_TRNA_BIOSYNTHESIS View Gene Set 1.706e-08 41 2.885e-07 11 Aminoacyl-tRNA biosynthesis www.broad.mit.e...
Broad KEGG_OOCYTE_MEIOSIS View Gene Set 3.882e-08 114 6.018e-07 12 Oocyte meiosis www.broad.mit.e...
Broad KEGG_DNA_REPLICATION View Gene Set 1.24e-07 36 1.775e-06 13 DNA replication www.broad.mit.e...
Broad KEGG_PROTEIN_EXPORT View Gene Set 7.173e-07 24 9.53e-06 14 Protein export www.broad.mit.e...
Broad KEGG_CITRATE_CYCLE_TCA_CYCLE View Gene Set 1.032e-06 32 1.28e-05 15 Citrate cycle (TCA cycle) www.broad.mit.e...
Broad KEGG_N_GLYCAN_BIOSYNTHESIS View Gene Set 1.513e-06 46 1.759e-05 16 N-Glycan biosynthesis www.broad.mit.e...
Broad KEGG_PROTEASOME View Gene Set 6.011e-06 48 6.577e-05 17 Proteasome www.broad.mit.e...
Broad KEGG_BASE_EXCISION_REPAIR View Gene Set 8.894e-06 35 9.191e-05 18 Base excision repair www.broad.mit.e...
Broad KEGG_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 1.021e-05 44 9.99e-05 19 Nucleotide excision repair www.broad.mit.e...
Broad KEGG_PEROXISOME View Gene Set 2.365e-05 78 0.0002199 20 Peroxisome www.broad.mit.e...
Broad KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION View Gene Set 6.496e-05 86 0.0005753 21 Progesterone-mediated oocyte maturation www.broad.mit.e...
Broad KEGG_PURINE_METABOLISM View Gene Set 0.0001051 157 0.0008455 22 Purine metabolism www.broad.mit.e...
Broad KEGG_ENDOMETRIAL_CANCER View Gene Set 0.0001076 52 0.0008455 22 Endometrial cancer www.broad.mit.e...
Broad KEGG_CHRONIC_MYELOID_LEUKEMIA View Gene Set 0.0001091 73 0.0008455 22 Chronic myeloid leukemia www.broad.mit.e...
Broad KEGG_CYSTEINE_AND_METHIONINE_METABOLISM View Gene Set 0.0001165 34 0.0008671 25 Cysteine and methionine metabolism www.broad.mit.e...
Broad KEGG_MTOR_SIGNALING_PATHWAY View Gene Set 0.000135 52 0.0009658 26 mTOR signaling pathway www.broad.mit.e...
Broad KEGG_APOPTOSIS View Gene Set 0.0001466 88 0.00101 27 Apoptosis www.broad.mit.e...
Broad KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS View Gene Set 0.0001637 11 0.001087 28 Valine leucine and isoleucine biosynthesis www.broad.mit.e...
Broad KEGG_NON_SMALL_CELL_LUNG_CANCER View Gene Set 0.0002164 54 0.001388 29 Non-small cell lung cancer www.broad.mit.e...
Broad KEGG_PANCREATIC_CANCER View Gene Set 0.0002427 70 0.001505 30 Pancreatic cancer www.broad.mit.e...
Broad KEGG_PROSTATE_CANCER View Gene Set 0.0002524 89 0.001514 31 Prostate cancer www.broad.mit.e...
Broad KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION View Gene Set 0.0004325 44 0.002514 32 Valine leucine and isoleucine degradation www.broad.mit.e...
Broad KEGG_MISMATCH_REPAIR View Gene Set 0.0005584 23 0.003147 33 Mismatch repair www.broad.mit.e...
Broad KEGG_RNA_POLYMERASE View Gene Set 0.0006618 29 0.00362 34 RNA polymerase www.broad.mit.e...
Broad KEGG_COLORECTAL_CANCER View Gene Set 0.0007932 62 0.004215 35 Colorectal cancer www.broad.mit.e...
Broad KEGG_ACUTE_MYELOID_LEUKEMIA View Gene Set 0.000974 60 0.005033 36 Acute myeloid leukemia www.broad.mit.e...
Broad KEGG_PROPANOATE_METABOLISM View Gene Set 0.001199 33 0.006028 37 Propanoate metabolism www.broad.mit.e...
Broad KEGG_SMALL_CELL_LUNG_CANCER View Gene Set 0.0013 84 0.006363 38 Small cell lung cancer www.broad.mit.e...
Broad KEGG_LYSINE_DEGRADATION View Gene Set 0.001622 44 0.007738 39 Lysine degradation www.broad.mit.e...
Broad KEGG_STEROID_BIOSYNTHESIS View Gene Set 0.001668 17 0.007754 40 Steroid biosynthesis www.broad.mit.e...
Broad KEGG_ONE_CARBON_POOL_BY_FOLATE View Gene Set 0.001916 17 0.008544 41 One carbon pool by folate www.broad.mit.e...
Broad KEGG_NOTCH_SIGNALING_PATHWAY View Gene Set 0.001929 47 0.008544 41 Notch signaling pathway www.broad.mit.e...
Broad KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION View Gene Set 0.002342 59 0.01013 43 Pathogenic Escherichia coli infection www.broad.mit.e...
Broad KEGG_PYRUVATE_METABOLISM View Gene Set 0.003748 40 0.01584 44 Pyruvate metabolism www.broad.mit.e...
Broad KEGG_INSULIN_SIGNALING_PATHWAY View Gene Set 0.005358 137 0.02215 45 Insulin signaling pathway www.broad.mit.e...
Broad KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS View Gene Set 0.006283 53 0.02541 46 Amyotrophic lateral sclerosis (ALS) www.broad.mit.e...
Broad KEGG_RENAL_CELL_CARCINOMA View Gene Set 0.007121 70 0.02818 47 Renal cell carcinoma www.broad.mit.e...
Broad KEGG_HOMOLOGOUS_RECOMBINATION View Gene Set 0.008695 28 0.03312 48 Homologous recombination www.broad.mit.e...
Broad KEGG_THYROID_CANCER View Gene Set 0.008726 29 0.03312 48 Thyroid cancer www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.REACTOME

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad REACTOME_GENE_EXPRESSION View Gene Set 4.584e-53 415 1.971e-50 1 Genes involved in Gene Expression www.broad.mit.e...
Broad REACTOME_CELL_CYCLE_MITOTIC View Gene Set 2.582e-36 306 5.552e-34 2 Genes involved in Cell Cycle Mitotic www.broad.mit.e...
Broad REACTOME_TRANSLATION View Gene Set 2.006e-31 120 2.876e-29 3 Genes involved in Translation www.broad.mit.e...
Broad REACTOME_INFLUENZA_LIFE_CYCLE View Gene Set 7.635e-30 137 8.207e-28 4 Genes involved in Influenza Life Cycle www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_PROTEINS View Gene Set 3.522e-29 215 3.029e-27 5 Genes involved in Metabolism of proteins www.broad.mit.e...
Broad REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA View Gene Set 9.162e-29 128 6.566e-27 6 Genes involved in Processing of Capped Intron-Containing Pre-mRNA www.broad.mit.e...
Broad REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT View Gene Set 1.264e-27 106 6.793e-26 7 Genes involved in GTP hydrolysis and joining of the 60S ribosomal subunit www.broad.mit.e...
Broad REACTOME_MITOTIC_M_M_G1_PHASES View Gene Set 1.218e-27 157 6.793e-26 7 Genes involved in Mitotic M-M/G1 phases www.broad.mit.e...
Broad REACTOME_DIABETES_PATHWAYS View Gene Set 2.115e-24 383 1.011e-22 9 Genes involved in Diabetes pathways www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_RNA View Gene Set 2.985e-24 95 1.283e-22 10 Genes involved in Metabolism of RNA www.broad.mit.e...
Broad REACTOME_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS View Gene Set 7.421e-24 95 2.901e-22 11 Genes involved in Formation of a pool of free 40S subunits www.broad.mit.e...
Broad REACTOME_FORMATION_AND_MATURATION_OF_MRNA_TRANSCRIPT View Gene Set 5.494e-23 142 1.969e-21 12 Genes involved in Formation and Maturation of mRNA Transcript www.broad.mit.e...
Broad REACTOME_ELONGATION_AND_PROCESSING_OF_CAPPED_TRANSCRIPTS View Gene Set 5.99e-23 124 1.981e-21 13 Genes involved in Elongation and Processing of Capped Transcripts www.broad.mit.e...
Broad REACTOME_INSULIN_SYNTHESIS_AND_SECRETION View Gene Set 5.169e-22 129 1.588e-20 14 Genes involved in Insulin Synthesis and Secretion www.broad.mit.e...
Broad REACTOME_PEPTIDE_CHAIN_ELONGATION View Gene Set 1.38e-21 84 3.956e-20 15 Genes involved in Peptide chain elongation www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING View Gene Set 1.794e-21 97 4.821e-20 16 Genes involved in mRNA Splicing www.broad.mit.e...
Broad REACTOME_VIRAL_MRNA_TRANSLATION View Gene Set 3.741e-21 84 9.462e-20 17 Genes involved in Viral mRNA Translation www.broad.mit.e...
Broad REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION View Gene Set 5.334e-21 100 1.274e-19 18 Genes involved in Influenza Viral RNA Transcription and Replication www.broad.mit.e...
Broad REACTOME_MITOTIC_PROMETAPHASE View Gene Set 8.361e-18 92 1.892e-16 19 Genes involved in Mitotic Prometaphase www.broad.mit.e...
Broad REACTOME_HIV_INFECTION View Gene Set 1.257e-17 183 2.703e-16 20 Genes involved in HIV Infection www.broad.mit.e...
Broad REACTOME_CELL_CYCLE_CHECKPOINTS View Gene Set 1.917e-17 110 3.926e-16 21 Genes involved in Cell Cycle Checkpoints www.broad.mit.e...
Broad REACTOME_TRANSLATION_INITIATION_COMPLEX_FORMATION View Gene Set 1.224e-16 56 2.393e-15 22 Genes involved in Translation initiation complex formation www.broad.mit.e...
Broad REACTOME_G1_S_TRANSITION View Gene Set 1.252e-15 102 2.34e-14 23 Genes involved in G1/S Transition www.broad.mit.e...
Broad REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS View Gene Set 5.662e-15 120 1.014e-13 24 Genes involved in Host Interactions of HIV factors www.broad.mit.e...
Broad REACTOME_S_PHASE View Gene Set 1.581e-14 103 2.719e-13 25 Genes involved in S Phase www.broad.mit.e...
Broad REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS View Gene Set 2.703e-14 101 4.471e-13 26 Genes involved in Regulation of gene expression in beta cells www.broad.mit.e...
Broad REACTOME_SNRNP_ASSEMBLY View Gene Set 1.264e-13 50 2.012e-12 27 Genes involved in snRNP Assembly www.broad.mit.e...
Broad REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX View Gene Set 4.472e-13 49 6.867e-12 28 Genes involved in Formation of the ternary complex and subsequently the 43S complex www.broad.mit.e...
Broad REACTOME_ELECTRON_TRANSPORT_CHAIN View Gene Set 1.343e-12 75 1.992e-11 29 Genes involved in Electron Transport Chain www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_MRNA View Gene Set 2.07e-12 45 2.966e-11 30 Genes involved in Metabolism of mRNA www.broad.mit.e...
Broad REACTOME_HIV_LIFE_CYCLE View Gene Set 2.514e-12 103 3.487e-11 31 Genes involved in HIV Life Cycle www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION View Gene Set 2.893e-12 188 3.887e-11 32 Genes involved in Transcription www.broad.mit.e...
Broad REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE View Gene Set 5.75e-12 90 7.493e-11 33 Genes involved in Late Phase of HIV Life Cycle www.broad.mit.e...
Broad REACTOME_GLUCOSE_REGULATION_OF_INSULIN_SECRETION View Gene Set 2.839e-11 161 3.591e-10 34 Genes involved in Glucose Regulation of Insulin Secretion www.broad.mit.e...
Broad REACTOME_REGULATION_OF_APC_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE View Gene Set 3.484e-11 71 4.28e-10 35 Genes involved in Regulation of APC/C activators between G1/S and early anaphase www.broad.mit.e...
Broad REACTOME_DNA_REPLICATION_PRE_INITIATION View Gene Set 3.622e-11 76 4.327e-10 36 Genes involved in DNA Replication Pre-Initiation www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRON_CONTAINING_TRANSCRIPT View Gene Set 4.635e-11 42 5.387e-10 37 Genes involved in Transport of Mature mRNA derived from an Intron-Containing Transcript www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_DNA View Gene Set 7.889e-11 89 8.927e-10 38 Genes involved in Synthesis of DNA www.broad.mit.e...
Broad REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT View Gene Set 8.582e-11 114 9.462e-10 39 Genes involved in Regulation of beta-cell development www.broad.mit.e...
Broad REACTOME_INTEGRATION_OF_ENERGY_METABOLISM View Gene Set 1.406e-10 229 1.511e-09 40 Genes involved in Integration of energy metabolism www.broad.mit.e...
Broad REACTOME_M_G1_TRANSITION View Gene Set 3.604e-10 61 3.78e-09 41 Genes involved in M/G1 Transition www.broad.mit.e...
Broad REACTOME_METABLISM_OF_NUCLEOTIDES View Gene Set 6.433e-10 71 6.586e-09 42 Genes involved in Metablism of nucleotides www.broad.mit.e...
Broad REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A View Gene Set 8.28e-10 63 8.28e-09 43 Genes involved in Cdc20:Phospho-APC/C mediated degradation of Cyclin A www.broad.mit.e...
Broad REACTOME_G2_M_CHECKPOINTS View Gene Set 1.054e-09 43 1.03e-08 44 Genes involved in G2/M Checkpoints www.broad.mit.e...
Broad REACTOME_REV_MEDIATED_NUCLEAR_EXPORT_OF_HIV1_RNA View Gene Set 1.363e-09 31 1.302e-08 45 Genes involved in Rev-mediated nuclear export of HIV-1 RNA www.broad.mit.e...
Broad REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN View Gene Set 1.873e-09 30 1.75e-08 46 Genes involved in Nuclear import of Rev protein www.broad.mit.e...
Broad REACTOME_TRNA_AMINOACYLATION View Gene Set 2.118e-09 40 1.937e-08 47 Genes involved in tRNA Aminoacylation www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION View Gene Set 3.675e-09 83 3.292e-08 48 Genes involved in RNA Polymerase II Transcription www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_THE_SLBP_INDEPENDENT_MATURE_MRNA View Gene Set 4.541e-09 32 3.985e-08 49 Genes involved in Transport of the SLBP independent Mature mRNA www.broad.mit.e...
Broad REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY View Gene Set 7.835e-09 29 6.738e-08 50 Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery www.broad.mit.e...
Broad REACTOME_VPR_MEDIATED_NUCLEAR_IMPORT_OF_PICS View Gene Set 9.736e-09 31 8.209e-08 51 Genes involved in Vpr-mediated nuclear import of PICs www.broad.mit.e...
Broad REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ View Gene Set 1.696e-08 58 1.402e-07 52 Genes involved in Cyclin E associated events during G1/S transition www.broad.mit.e...
Broad REACTOME_REGULATION_OF_INSULIN_SECRETION View Gene Set 2.688e-08 212 2.181e-07 53 Genes involved in Regulation of Insulin Secretion www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS View Gene Set 3.177e-08 29 2.502e-07 54 Genes involved in Transport of Ribonucleoproteins into the Host Nucleus www.broad.mit.e...
Broad REACTOME_DEADENYLATION_OF_MRNA View Gene Set 3.2e-08 21 2.502e-07 54 Genes involved in Deadenylation of mRNA www.broad.mit.e...
Broad REACTOME_ORC1_REMOVAL_FROM_CHROMATIN View Gene Set 3.459e-08 63 2.656e-07 56 Genes involved in Orc1 removal from chromatin www.broad.mit.e...
Broad REACTOME_MEMBRANE_TRAFFICKING View Gene Set 4.021e-08 78 3.034e-07 57 Genes involved in Membrane Trafficking www.broad.mit.e...
Broad REACTOME_SIGNALING_BY_WNT View Gene Set 5.546e-08 58 4.111e-07 58 Genes involved in Signaling by Wnt www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS View Gene Set 6.726e-08 37 4.902e-07 59 Genes involved in Activation of ATR in response to replication stress www.broad.mit.e...
Broad REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION View Gene Set 1.014e-07 23 7.264e-07 60 Genes involved in Cytosolic tRNA aminoacylation www.broad.mit.e...
Broad REACTOME_DNA_REPAIR View Gene Set 1.393e-07 102 9.817e-07 61 Genes involved in DNA Repair www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_AMINO_ACIDS View Gene Set 1.989e-07 162 1.38e-06 62 Genes involved in Metabolism of amino acids www.broad.mit.e...
Broad REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE View Gene Set 2.205e-07 47 1.505e-06 63 Genes involved in Regulation of ornithine decarboxylase (ODC) www.broad.mit.e...
Broad REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 View Gene Set 2.304e-07 52 1.548e-06 64 Genes involved in SCF(Skp2)-mediated degradation of p2721 www.broad.mit.e...
Broad REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC View Gene Set 2.527e-07 57 1.672e-06 65 Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C www.broad.mit.e...
Broad REACTOME_DNA_STRAND_ELONGATION View Gene Set 3.692e-07 31 2.406e-06 66 Genes involved in DNA strand elongation www.broad.mit.e...
Broad REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 View Gene Set 5.649e-07 48 3.625e-06 67 Genes involved in SCF-beta-TrCP mediated degradation of Emi1 www.broad.mit.e...
Broad REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX View Gene Set 6.808e-07 52 4.305e-06 68 Genes involved in CDT1 association with the CDC6:ORC:origin complex www.broad.mit.e...
Broad REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G View Gene Set 1.004e-06 47 6.254e-06 69 Genes involved in Vif-mediated degradation of APOBEC3G www.broad.mit.e...
Broad REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE View Gene Set 1.18e-06 43 7.248e-06 70 Genes involved in p53-Independent DNA Damage Response www.broad.mit.e...
Broad REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN View Gene Set 1.252e-06 29 7.585e-06 71 Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein www.broad.mit.e...
Broad REACTOME_PURINE_METABOLISM View Gene Set 1.276e-06 30 7.618e-06 72 Genes involved in Purine metabolism www.broad.mit.e...
Broad REACTOME_MTOR_SIGNALLING View Gene Set 1.31e-06 27 7.714e-06 73 Genes involved in mTOR signalling www.broad.mit.e...
Broad REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION View Gene Set 1.581e-06 33 9.185e-06 74 Genes involved in E2F mediated regulation of DNA replication www.broad.mit.e...
Broad REACTOME_STABILIZATION_OF_P53 View Gene Set 1.966e-06 46 1.127e-05 75 Genes involved in Stabilization of p53 www.broad.mit.e...
Broad REACTOME_MRNA_3_END_PROCESSING View Gene Set 2.524e-06 25 1.428e-05 76 Genes involved in mRNA 3-end processing www.broad.mit.e...
Broad REACTOME_GLUCOSE_TRANSPORT View Gene Set 3.554e-06 38 1.985e-05 77 Genes involved in Glucose transport www.broad.mit.e...
Broad REACTOME_CYCLIN_A1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION View Gene Set 4.187e-06 15 2.308e-05 78 Genes involved in Cyclin A1 associated events during G2/M transition www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_III_AND_MITOCHONDRIAL_TRANSCRIPTION View Gene Set 4.337e-06 120 2.361e-05 79 Genes involved in RNA Polymerase I RNA Polymerase III and Mitochondrial Transcription www.broad.mit.e...
Broad REACTOME_G2_M_TRANSITION View Gene Set 5.709e-06 84 3.068e-05 80 Genes involved in G2/M Transition www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_CARBOHYDRATES View Gene Set 6.13e-06 119 3.254e-05 81 Genes involved in Metabolism of carbohydrates www.broad.mit.e...
Broad REACTOME_APOPTOSIS View Gene Set 6.52e-06 129 3.419e-05 82 Genes involved in Apoptosis www.broad.mit.e...
Broad REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS View Gene Set 8.011e-06 11 4.15e-05 83 Genes involved in Purine ribonucleoside monophosphate biosynthesis www.broad.mit.e...
Broad REACTOME_E2F_TRANSCRIPTIONAL_TARGETS_AT_G1_S View Gene Set 8.401e-06 22 4.301e-05 84 Genes involved in E2F transcriptional targets at G1/S www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING_MINOR_PATHWAY View Gene Set 9.474e-06 38 4.793e-05 85 Genes involved in mRNA Splicing - Minor Pathway www.broad.mit.e...
Broad REACTOME_CITRIC_ACID_CYCLE View Gene Set 1.553e-05 19 7.767e-05 86 Genes involved in Citric acid cycle (TCA cycle) www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX View Gene Set 2.064e-05 30 0.000102 87 Genes involved in Activation of the pre-replicative complex www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME View Gene Set 2.576e-05 59 0.0001259 88 Genes involved in Transcription of the HIV genome www.broad.mit.e...
Broad REACTOME_UNWINDING_OF_DNA View Gene Set 2.775e-05 11 0.0001341 89 Genes involved in Unwinding of DNA www.broad.mit.e...
Broad REACTOME_PEROXISOMAL_LIPID_METABOLISM View Gene Set 3.806e-05 20 0.0001818 90 Genes involved in Peroxisomal lipid metabolism www.broad.mit.e...
Broad REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING View Gene Set 4.363e-05 61 0.0002061 91 Genes involved in Clathrin derived vesicle budding www.broad.mit.e...
Broad REACTOME_EXTENSION_OF_TELOMERES View Gene Set 5.666e-05 28 0.0002648 92 Genes involved in Extension of Telomeres www.broad.mit.e...
Broad REACTOME_INACTIVATION_OF_APC_VIA_DIRECT_INHIBITION_OF_THE_APCOMPLEX View Gene Set 7.327e-05 18 0.0003388 93 Genes involved in Inactivation of APC/C via direct inhibition of the APC/C complex www.broad.mit.e...
Broad REACTOME_TELOMERE_MAINTENANCE View Gene Set 7.61e-05 77 0.0003481 94 Genes involved in Telomere Maintenance www.broad.mit.e...
Broad REACTOME_VITAMIN_B5_(PANTOTHENATE)_METABOLISM View Gene Set 7.758e-05 11 0.0003511 95 Genes involved in Vitamin B5 (pantothenate) metabolism www.broad.mit.e...
Broad REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS View Gene Set 8.907e-05 54 0.000399 96 Genes involved in Golgi Associated Vesicle Biogenesis www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION View Gene Set 9.07e-05 34 0.0004021 97 Genes involved in RNA Polymerase III Transcription www.broad.mit.e...
Broad REACTOME_APCDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B View Gene Set 0.0001083 18 0.0004753 98 Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B www.broad.mit.e...
Broad REACTOME_TRANSFORMATION_OF_LANOSTEROL_TO_CHOLESTEROL View Gene Set 0.0001132 10 0.0004917 99 Genes involved in Transformation of lanosterol to cholesterol www.broad.mit.e...
Broad REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING View Gene Set 0.0001271 15 0.0005409 100 Genes involved in Formation of ATP by chemiosmotic coupling www.broad.mit.e...
Broad REACTOME_PYRUVATE_METABOLISM_AND_TCA_CYCLE View Gene Set 0.000126 36 0.0005409 100 Genes involved in Pyruvate metabolism and TCA cycle www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_ELONGATION View Gene Set 0.000129 41 0.000544 102 Genes involved in HIV-1 Transcription Elongation www.broad.mit.e...
Broad REACTOME_PHOSPHORYLATION_OF_THE_APC View Gene Set 0.0001408 17 0.000582 103 Genes involved in Phosphorylation of the APC/C www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS View Gene Set 0.0001399 29 0.000582 103 Genes involved in Association of TriC/CCT with target proteins during biosynthesis www.broad.mit.e...
Broad REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION View Gene Set 0.0001446 20 0.000592 105 Genes involved in Mitochondrial tRNA aminoacylation www.broad.mit.e...
Broad REACTOME_MTORC1_MEDIATED_SIGNALLING View Gene Set 0.0001577 11 0.0006397 106 Genes involved in mTORC1-mediated signalling www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS View Gene Set 0.0001933 42 0.0007767 107 Genes involved in Metabolism of vitamins and cofactors www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_TERMINATION View Gene Set 0.0003193 17 0.001271 108 Genes involved in RNA Polymerase III Transcription Termination www.broad.mit.e...
Broad REACTOME_CHOLESTEROL_BIOSYNTHESIS View Gene Set 0.0003617 21 0.001421 109 Genes involved in Cholesterol biosynthesis www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE View Gene Set 0.0003634 11 0.001421 109 Genes involved in mRNA Decay by 3' to 5' Exoribonuclease www.broad.mit.e...
Broad REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING View Gene Set 0.0003816 50 0.001478 111 Genes involved in Chaperonin-mediated protein folding www.broad.mit.e...
Broad REACTOME_CENTROSOME_MATURATION View Gene Set 0.0004698 72 0.001804 112 Genes involved in Centrosome maturation www.broad.mit.e...
Broad REACTOME_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 0.0006003 49 0.002284 113 Genes involved in Nucleotide Excision Repair www.broad.mit.e...
Broad REACTOME_LAGGING_STRAND_SYNTHESIS View Gene Set 0.0006618 20 0.002496 114 Genes involved in Lagging Strand Synthesis www.broad.mit.e...
Broad REACTOME_IRS_RELATED_EVENTS View Gene Set 0.0006946 79 0.002597 115 Genes involved in IRS-related events www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION View Gene Set 0.0007716 24 0.00286 116 Genes involved in RNA PolymeraseTranscription Initiation www.broad.mit.e...
Broad REACTOME_MICRORNA_BIOGENESIS View Gene Set 0.0008367 18 0.003075 117 Genes involved in MicroRNA biogenesis www.broad.mit.e...
Broad REACTOME_P38MAPK_EVENTS View Gene Set 0.001083 13 0.003945 118 Genes involved in p38MAPK events www.broad.mit.e...
Broad REACTOME_GLOBAL_GENOMIC_NER View Gene Set 0.001119 33 0.004042 119 Genes involved in Global Genomic NER (GG-NER) www.broad.mit.e...
Broad REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES View Gene Set 0.001144 18 0.004099 120 Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates www.broad.mit.e...
Broad REACTOME_TAT_MEDIATED_HIV1_ELONGATION_ARREST_AND_RECOVERY View Gene Set 0.001157 30 0.004112 121 Genes involved in Tat-mediated HIV-1 elongation arrest and recovery www.broad.mit.e...
Broad REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES View Gene Set 0.001197 62 0.004202 122 Genes involved in Loss of Nlp from mitotic centrosomes www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_COUPLED_NER View Gene Set 0.001202 44 0.004202 122 Genes involved in Transcription-coupled NER (TC-NER) www.broad.mit.e...
Broad REACTOME_PURINE_SALVAGE_REACTIONS View Gene Set 0.001249 12 0.004332 124 Genes involved in Purine salvage reactions www.broad.mit.e...
Broad REACTOME_SIGNALING_BY_EGFR View Gene Set 0.001329 48 0.004565 125 Genes involved in Signaling by EGFR www.broad.mit.e...
Broad REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC:ORIGIN_COMPLEX View Gene Set 0.001338 11 0.004565 125 Genes involved in CDC6 association with the ORC:origin complex www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_INITIATION View Gene Set 0.001354 39 0.004585 127 Genes involved in HIV-1 Transcription Initiation www.broad.mit.e...
Broad REACTOME_MRNA_PROCESSING View Gene Set 0.001406 32 0.004686 128 Genes involved in mRNA Processing www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE View Gene Set 0.001398 20 0.004686 128 Genes involved in RNA Polymerase I Promoter Escape www.broad.mit.e...
Broad REACTOME_REPAIR_SYNTHESIS_OF_PATCH_27_30_BASES_LONG_BY_DNA_POLYMERASE View Gene Set 0.001468 15 0.004857 130 Genes involved in Repair synthesis of patch ~27-30 bases long by DNA polymerase www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_CHAPERONES_BY_IRE1_ALPHA View Gene Set 0.001529 10 0.005019 131 Genes involved in Activation of Chaperones by IRE1alpha www.broad.mit.e...
Broad REACTOME_G1_PHASE View Gene Set 0.001548 16 0.005042 132 Genes involved in G1 Phase www.broad.mit.e...
Broad REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION View Gene Set 0.001579 10 0.005105 133 Genes involved in E2F-enabled inhibition of pre-replication complex formation www.broad.mit.e...
Broad REACTOME_ERK_MAPK_TARGETS View Gene Set 0.00161 21 0.005137 134 Genes involved in ERK/MAPK targets www.broad.mit.e...
Broad REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX View Gene Set 0.001619 32 0.005137 134 Genes involved in Formation of the Early Elongation Complex www.broad.mit.e...
Broad REACTOME_RNA_POL_II_CTD_PHOSPHORYLATION_AND_INTERACTION_WITH_CE View Gene Set 0.001625 26 0.005137 134 Genes involved in RNA Pol II CTD phosphorylation and interaction with CE www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE View Gene Set 0.001823 13 0.005723 137 Genes involved in mRNA Decay by 5' to 3' Exoribonuclease www.broad.mit.e...
Broad REACTOME_SIGNALLING_TO_RAS View Gene Set 0.001939 26 0.006043 138 Genes involved in Signalling to RAS www.broad.mit.e...
Broad REACTOME_DOUBLE_STRAND_BREAK_REPAIR View Gene Set 0.002055 21 0.006356 139 Genes involved in Double-Strand Break Repair www.broad.mit.e...
Broad REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION View Gene Set 0.002154 24 0.006615 140 Genes involved in Nuclear Events (kinase and transcription factor activation) www.broad.mit.e...
Broad REACTOME_UNFOLDED_PROTEIN_RESPONSE View Gene Set 0.002185 19 0.006663 141 Genes involved in Unfolded Protein Response www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION View Gene Set 0.002214 29 0.006705 142 Genes involved in RNA Polymerase III Transcription Initiation www.broad.mit.e...
Broad REACTOME_POLYMERASE_SWITCHING View Gene Set 0.002508 14 0.007541 143 Genes involved in Polymerase switching www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE View Gene Set 0.002768 14 0.008266 144 Genes involved in Removal of the Flap Intermediate www.broad.mit.e...
Broad REACTOME_LYSOSOME_VESICLE_BIOGENESIS View Gene Set 0.002834 24 0.008405 145 Genes involved in Lysosome Vesicle Biogenesis www.broad.mit.e...
Broad REACTOME_SHC_MEDIATED_SIGNALLING View Gene Set 0.00288 12 0.008481 146 Genes involved in SHC-mediated signalling www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND View Gene Set 0.003067 10 0.00897 147 Genes involved in Removal of the Flap Intermediate from the C-strand www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER View Gene Set 0.003715 20 0.01079 148 Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter www.broad.mit.e...
Broad REACTOME_GLUCOSE_METABOLISM View Gene Set 0.003849 56 0.01106 149 Genes involved in Glucose metabolism www.broad.mit.e...
Broad REACTOME_ERKS_ARE_INACTIVATED View Gene Set 0.003859 12 0.01106 149 Genes involved in ERKs are inactivated www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL View Gene Set 0.004149 17 0.01182 151 Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_PROMOTER_CLEARANCE View Gene Set 0.004261 82 0.01205 152 Genes involved in RNA PolymerasePromoter Clearance www.broad.mit.e...
Broad REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC View Gene Set 0.004375 28 0.0123 153 Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_DNA_PATCH_CONTAINING_ABASIC_RESIDUE View Gene Set 0.004496 15 0.01255 154 Genes involved in Removal of DNA patch containing abasic residue www.broad.mit.e...
Broad REACTOME_BASE_EXCISION_REPAIR View Gene Set 0.005268 18 0.01461 155 Genes involved in Base Excision Repair www.broad.mit.e...
Broad REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK View Gene Set 0.005388 17 0.01485 156 Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK www.broad.mit.e...
Broad REACTOME_PYRIMIDINE_METABOLISM View Gene Set 0.005535 22 0.01516 157 Genes involved in Pyrimidine metabolism www.broad.mit.e...
Broad REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENES_FAMILY View Gene Set 0.006464 10 0.01759 158 Genes involved in Zinc influx into cells by the SLC39 Genes family www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS View Gene Set 0.007154 228 0.01935 159 Genes involved in Metabolism of lipids and lipoproteins www.broad.mit.e...
Broad REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES View Gene Set 0.00745 11 0.02002 160 Genes involved in Recruitment of NuMA to mitotic centrosomes www.broad.mit.e...
Broad REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT View Gene Set 0.007599 23 0.0203 161 Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PREREPLICATIVE_COMPLEX View Gene Set 0.007665 12 0.02035 162 Genes involved in Association of licensing factors with the pre-replicative complex www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER View Gene Set 0.007907 22 0.02086 163 Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter www.broad.mit.e...
Broad REACTOME_SHC_RELATED_EVENTS View Gene Set 0.008017 14 0.02102 164 Genes involved in SHC-related events www.broad.mit.e...
Broad REACTOME_GRB2_EVENTS_IN_EGFR_SIGNALING View Gene Set 0.008452 13 0.02203 165 Genes involved in Grb2 events in EGFR signaling www.broad.mit.e...
Broad REACTOME_DOWN_STREAM_SIGNAL_TRANSDUCTION View Gene Set 0.008577 35 0.02222 166 Genes involved in Down-stream signal transduction www.broad.mit.e...
Broad REACTOME_SIGNALLING_BY_NGF View Gene Set 0.008749 216 0.02253 167 Genes involved in Signalling by NGF www.broad.mit.e...
Broad REACTOME_COPI_MEDIATED_TRANSPORT View Gene Set 0.008913 10 0.02271 168 Genes involved in COPI Mediated Transport www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_TERMINATION View Gene Set 0.008924 21 0.02271 168 Genes involved in RNA PolymeraseTranscription Termination www.broad.mit.e...
Broad REACTOME_BETACATENIN_PHOSPHORYLATION_CASCADE View Gene Set 0.009489 13 0.024 170 Genes involved in Beta-catenin phosphorylation cascade www.broad.mit.e...
Broad REACTOME_FURTHER_PLATELET_RELEASATE View Gene Set 0.01028 24 0.02571 171 Genes involved in Further platelet releasate www.broad.mit.e...
Broad REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR View Gene Set 0.01028 15 0.02571 171 Genes involved in Homologous Recombination Repair www.broad.mit.e...
Broad REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM View Gene Set 0.01152 17 0.02863 173 Genes involved in Branched-chain amino acid catabolism www.broad.mit.e...
Broad REACTOME_CONVERSION_FROM_APC_CDC20_TO_APC_CDH1_IN_LATE_ANAPHASE View Gene Set 0.01261 17 0.03116 174 Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_CHAIN_ELONGATION View Gene Set 0.01375 12 0.03378 175 Genes involved in RNA Polymerase III Chain Elongation www.broad.mit.e...
Broad REACTOME_PI3K_AKT_SIGNALLING View Gene Set 0.01431 37 0.03496 176 Genes involved in PI3K/AKT signalling www.broad.mit.e...
Broad REACTOME_TRKA_SIGNALLING_FROM_THE_PLASMA_MEMBRANE View Gene Set 0.01445 103 0.0351 177 Genes involved in TRKA signalling from the plasma membrane www.broad.mit.e...
Broad REACTOME_METAL_ION_SLC_TRANSPORTERS View Gene Set 0.01493 23 0.03606 178 Genes involved in Metal ion SLC transporters www.broad.mit.e...
Broad REACTOME_SOS_MEDIATED_SIGNALLING View Gene Set 0.01544 13 0.03709 179 Genes involved in SOS-mediated signalling www.broad.mit.e...
Broad REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS View Gene Set 0.01575 11 0.03763 180 Genes involved in Apoptotic cleavage of cell adhesion proteins www.broad.mit.e...
Broad REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE View Gene Set 0.01676 17 0.03981 181 Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS View Gene Set 0.01967 26 0.04648 182 Genes involved in Synthesis of GPI-anchored proteins www.broad.mit.e...
Broad REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS View Gene Set 0.02012 14 0.04727 183 Genes involved in Viral Messenger RNA Synthesis www.broad.mit.e...
Broad REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 View Gene Set 0.02057 14 0.04807 184 Genes involved in Regulation of AMPK activity via LKB1 www.broad.mit.e...

Gene Set Collection: Broad.c3.MIR

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad GTGCCTT MIR-506 View Gene Set 3.007e-07 605 2.215e-05 1 Targets of MicroRNA GTGCCTT MIR-506 www.broad.mit.e... MIR-506...
Broad TTTTGAG MIR-373 View Gene Set 1.724e-07 189 2.215e-05 1 Targets of MicroRNA TTTTGAG MIR-373 www.broad.mit.e... MIR-373...
Broad TAATGTG MIR-323 View Gene Set 2.153e-07 135 2.215e-05 1 Targets of MicroRNA TAATGTG MIR-323 www.broad.mit.e... MIR-323...
Broad ACCATTT MIR-522 View Gene Set 5.866e-07 137 3.241e-05 4 Targets of MicroRNA ACCATTT MIR-522 www.broad.mit.e... MIR-522...
Broad CTTGTAT MIR-381 View Gene Set 9.28e-07 167 4.102e-05 5 Targets of MicroRNA CTTGTAT MIR-381 www.broad.mit.e... MIR-381...
Broad TGCTGCT MIR-15A MIR-16 MIR-15B MIR-195 MIR-424 MIR-497 View Gene Set 1.474e-06 512 5.428e-05 6 Targets of MicroRNA TGCTGCT MIR-15A MIR-16 MIR-15B MIR-195 MIR-424 MIR-497 www.broad.mit.e... MIR-15A... MIR-16... MIR-15B... MIR-195... MIR-424... MIR-497...
Broad ATGTTAA MIR-302C View Gene Set 4.017e-06 206 0.0001152 7 Targets of MicroRNA ATGTTAA MIR-302C www.broad.mit.e... MIR-302C...
Broad ACACTAC MIR-142-3P View Gene Set 4.17e-06 110 0.0001152 7 Targets of MicroRNA ACACTAC MIR-142-3P www.broad.mit.e... MIR-142-3P...
Broad ATGAAGG MIR-205 View Gene Set 6.647e-06 128 0.0001632 9 Targets of MicroRNA ATGAAGG MIR-205 www.broad.mit.e... MIR-205...
Broad TGAGATT MIR-216 View Gene Set 1.585e-05 90 0.0003502 10 Targets of MicroRNA TGAGATT MIR-216 www.broad.mit.e... MIR-216...
Broad CAGTGTT MIR-141 MIR-200A View Gene Set 2.031e-05 262 0.000408 11 Targets of MicroRNA CAGTGTT MIR-141 MIR-200A www.broad.mit.e... MIR-141... MIR-200A...
Broad GTTTGTT MIR-495 View Gene Set 2.287e-05 205 0.0004211 12 Targets of MicroRNA GTTTGTT MIR-495 www.broad.mit.e... MIR-495...
Broad GTGCCAT MIR-183 View Gene Set 3.067e-05 152 0.0004842 13 Targets of MicroRNA GTGCCAT MIR-183 www.broad.mit.e... MIR-183...
Broad ATATGCA MIR-448 View Gene Set 2.88e-05 184 0.0004842 13 Targets of MicroRNA ATATGCA MIR-448 www.broad.mit.e... MIR-448...
Broad TGCCTTA MIR-124A View Gene Set 3.663e-05 471 0.0005397 15 Targets of MicroRNA TGCCTTA MIR-124A www.broad.mit.e... MIR-124A...
Broad TGAATGT MIR-181A MIR-181B MIR-181C MIR-181D View Gene Set 5.642e-05 418 0.0007793 16 Targets of MicroRNA TGAATGT MIR-181A MIR-181B MIR-181C MIR-181D www.broad.mit.e... MIR-181A... MIR-181B... MIR-181C... MIR-181D...
Broad ACTGCAG MIR-17-3P View Gene Set 6.069e-05 88 0.0007889 17 Targets of MicroRNA ACTGCAG MIR-17-3P www.broad.mit.e... MIR-17-3P...
Broad TGCACTT MIR-519C MIR-519B MIR-519A View Gene Set 0.0001134 377 0.001163 18 Targets of MicroRNA TGCACTT MIR-519C MIR-519B MIR-519A www.broad.mit.e... MIR-519C... MIR-519B... MIR-519A...
Broad ACATTCC MIR-1 MIR-206 View Gene Set 0.0001131 248 0.001163 18 Targets of MicroRNA ACATTCC MIR-1 MIR-206 www.broad.mit.e... MIR-1... MIR-206...
Broad GGGACCA MIR-133A MIR-133B View Gene Set 0.0001133 173 0.001163 18 Targets of MicroRNA GGGACCA MIR-133A MIR-133B www.broad.mit.e... MIR-133A... MIR-133B...
Broad GTACTGT MIR-101 View Gene Set 0.0001125 221 0.001163 18 Targets of MicroRNA GTACTGT MIR-101 www.broad.mit.e... MIR-101...
Broad TTTGCAG MIR-518A-2 View Gene Set 0.0001158 174 0.001163 18 Targets of MicroRNA TTTGCAG MIR-518A-2 www.broad.mit.e... MIR-518A-2...
Broad CATGTAA MIR-496 View Gene Set 0.0001386 150 0.001332 23 Targets of MicroRNA CATGTAA MIR-496 www.broad.mit.e... MIR-496...
Broad TTGCCAA MIR-182 View Gene Set 0.0001789 274 0.001521 24 Targets of MicroRNA TTGCCAA MIR-182 www.broad.mit.e... MIR-182...
Broad CAGCTTT MIR-320 View Gene Set 0.0001688 220 0.001521 24 Targets of MicroRNA CAGCTTT MIR-320 www.broad.mit.e... MIR-320...
Broad TCTGATA MIR-361 View Gene Set 0.0001772 74 0.001521 24 Targets of MicroRNA TCTGATA MIR-361 www.broad.mit.e... MIR-361...
Broad TGTGTGA MIR-377 View Gene Set 0.0001872 162 0.001532 27 Targets of MicroRNA TGTGTGA MIR-377 www.broad.mit.e... MIR-377...
Broad CATTTCA MIR-203 View Gene Set 0.0002081 235 0.001643 28 Targets of MicroRNA CATTTCA MIR-203 www.broad.mit.e... MIR-203...
Broad AGTCAGC MIR-345 View Gene Set 0.0002356 52 0.001796 29 Targets of MicroRNA AGTCAGC MIR-345 www.broad.mit.e... MIR-345...
Broad GACTGTT MIR-212 MIR-132 View Gene Set 0.0002886 134 0.002037 30 Targets of MicroRNA GACTGTT MIR-212 MIR-132 www.broad.mit.e... MIR-212... MIR-132...
Broad ATAACCT MIR-154 View Gene Set 0.0002812 51 0.002037 30 Targets of MicroRNA ATAACCT MIR-154 www.broad.mit.e... MIR-154...
Broad TATCTGG MIR-488 View Gene Set 0.0002949 49 0.002037 30 Targets of MicroRNA TATCTGG MIR-488 www.broad.mit.e... MIR-488...
Broad AATGTGA MIR-23A MIR-23B View Gene Set 0.0003806 356 0.002549 33 Targets of MicroRNA AATGTGA MIR-23A MIR-23B www.broad.mit.e... MIR-23A... MIR-23B...
Broad TACTTGA MIR-26A MIR-26B View Gene Set 0.0003991 258 0.002594 34 Targets of MicroRNA TACTTGA MIR-26A MIR-26B www.broad.mit.e... MIR-26A... MIR-26B...
Broad GAGACTG MIR-452 View Gene Set 0.0004283 78 0.002704 35 Targets of MicroRNA GAGACTG MIR-452 www.broad.mit.e... MIR-452...
Broad CTTTGTA MIR-524 View Gene Set 0.000555 375 0.003407 36 Targets of MicroRNA CTTTGTA MIR-524 www.broad.mit.e... MIR-524...
Broad CAGTATT MIR-200B MIR-200C MIR-429 View Gene Set 0.0006138 386 0.00357 37 Targets of MicroRNA CAGTATT MIR-200B MIR-200C MIR-429 www.broad.mit.e... MIR-200B... MIR-200C... MIR-429...
Broad TGCTTTG MIR-330 View Gene Set 0.000607 278 0.00357 37 Targets of MicroRNA TGCTTTG MIR-330 www.broad.mit.e... MIR-330...
Broad CTGTTAC MIR-194 View Gene Set 0.0008358 90 0.004736 39 Targets of MicroRNA CTGTTAC MIR-194 www.broad.mit.e... MIR-194...
Broad AAGCACT MIR-520F View Gene Set 0.0008707 198 0.00481 40 Targets of MicroRNA AAGCACT MIR-520F www.broad.mit.e... MIR-520F...
Broad ATTCTTT MIR-186 View Gene Set 0.0009094 232 0.004902 41 Targets of MicroRNA ATTCTTT MIR-186 www.broad.mit.e... MIR-186...
Broad GTCTTCC MIR-7 View Gene Set 0.0009911 132 0.005215 42 Targets of MicroRNA GTCTTCC MIR-7 www.broad.mit.e... MIR-7...
Broad ATTACAT MIR-380-3P View Gene Set 0.00102 87 0.005244 43 Targets of MicroRNA ATTACAT MIR-380-3P www.broad.mit.e... MIR-380-3P...
Broad ACACTGG MIR-199A MIR-199B View Gene Set 0.001053 134 0.00529 44 Targets of MicroRNA ACACTGG MIR-199A MIR-199B www.broad.mit.e... MIR-199A... MIR-199B...
Broad TTGGAGA MIR-515-5P MIR-519E View Gene Set 0.001153 120 0.005541 45 Targets of MicroRNA TTGGAGA MIR-515-5P MIR-519E www.broad.mit.e... MIR-515-5P... MIR-519E...
Broad TCCAGAG MIR-518C View Gene Set 0.001137 127 0.005541 45 Targets of MicroRNA TCCAGAG MIR-518C www.broad.mit.e... MIR-518C...
Broad ACTGAAA MIR-30A-3P MIR-30E-3P View Gene Set 0.001293 165 0.006081 47 Targets of MicroRNA ACTGAAA MIR-30A-3P MIR-30E-3P www.broad.mit.e... MIR-30A-3P... MIR-30E-3P...
Broad TTGGGAG MIR-150 View Gene Set 0.001544 65 0.007109 48 Targets of MicroRNA TTGGGAG MIR-150 www.broad.mit.e... MIR-150...
Broad ACAACTT MIR-382 View Gene Set 0.001902 64 0.008576 49 Targets of MicroRNA ACAACTT MIR-382 www.broad.mit.e... MIR-382...
Broad ACACTCC MIR-122A View Gene Set 0.00218 67 0.009637 50 Targets of MicroRNA ACACTCC MIR-122A www.broad.mit.e... MIR-122A...
Broad TTTGTAG MIR-520D View Gene Set 0.002232 279 0.00967 51 Targets of MicroRNA TTTGTAG MIR-520D www.broad.mit.e... MIR-520D...
Broad TAGGTCA MIR-192 MIR-215 View Gene Set 0.002424 37 0.0103 52 Targets of MicroRNA TAGGTCA MIR-192 MIR-215 www.broad.mit.e... MIR-192... MIR-215...
Broad ATCATGA MIR-433 View Gene Set 0.002537 94 0.01058 53 Targets of MicroRNA ATCATGA MIR-433 www.broad.mit.e... MIR-433...
Broad AGGTGCA MIR-500 View Gene Set 0.002973 79 0.01217 54 Targets of MicroRNA AGGTGCA MIR-500 www.broad.mit.e... MIR-500...
Broad AGCACTT MIR-93 MIR-302A MIR-302B MIR-302C MIR-302D MIR-372 MIR-373 MIR-520E MIR-520A MIR-526B MIR-520B MIR-520C MIR-520D View Gene Set 0.003535 281 0.01421 55 Targets of MicroRNA AGCACTT MIR-93 MIR-302A MIR-302B MIR-302C MIR-302D MIR-372 MIR-373 MIR-520E MIR-520A MIR-526B MIR-520B MIR-520C MIR-520D www.broad.mit.e... MIR-93... MIR-302A... MIR-302B... MIR-302C... MIR-302D... MIR-372... MIR-373... MIR-520E... MIR-520A... MIR-526B... MIR-520B... MIR-520C... MIR-520D...
Broad GTATGAT MIR-154 MIR-487 View Gene Set 0.005138 51 0.02028 56 Targets of MicroRNA GTATGAT MIR-154 MIR-487 www.broad.mit.e... MIR-154... MIR-487...
Broad AAAGGAT MIR-501 View Gene Set 0.006301 107 0.02401 57 Targets of MicroRNA AAAGGAT MIR-501 www.broad.mit.e... MIR-501...
Broad AAGGGAT MIR-188 View Gene Set 0.006252 65 0.02401 57 Targets of MicroRNA AAGGGAT MIR-188 www.broad.mit.e... MIR-188...
Broad AAGTCCA MIR-422B MIR-422A View Gene Set 0.00672 54 0.02517 59 Targets of MicroRNA AAGTCCA MIR-422B MIR-422A www.broad.mit.e... MIR-422B... MIR-422A...
Broad CTCTGGA MIR-520A MIR-525 View Gene Set 0.007333 128 0.02701 60 Targets of MicroRNA CTCTGGA MIR-520A MIR-525 www.broad.mit.e... MIR-520A... MIR-525...
Broad GGCAGTG MIR-324-3P View Gene Set 0.007935 82 0.02875 61 Targets of MicroRNA GGCAGTG MIR-324-3P www.broad.mit.e... MIR-324-3P...
Broad ACTGCCT MIR-34B View Gene Set 0.00819 190 0.02919 62 Targets of MicroRNA ACTGCCT MIR-34B www.broad.mit.e... MIR-34B...
Broad AGTCTTA MIR-499 View Gene Set 0.008671 60 0.03042 63 Targets of MicroRNA AGTCTTA MIR-499 www.broad.mit.e... MIR-499...
Broad TAGCTTT MIR-9 View Gene Set 0.009046 198 0.03124 64 Targets of MicroRNA TAGCTTT MIR-9 www.broad.mit.e... MIR-9...
Broad ATGTACA MIR-493 View Gene Set 0.009228 261 0.03137 65 Targets of MicroRNA ATGTACA MIR-493 www.broad.mit.e... MIR-493...
Broad GCACTTT MIR-17-5P MIR-20A MIR-106A MIR-106B MIR-20B MIR-519D View Gene Set 0.0114 506 0.03819 66 Targets of MicroRNA GCACTTT MIR-17-5P MIR-20A MIR-106A MIR-106B MIR-20B MIR-519D www.broad.mit.e... MIR-17-5P... MIR-20A... MIR-106A... MIR-106B... MIR-20B... MIR-519D...
Broad TCCAGAT MIR-516-5P View Gene Set 0.01233 93 0.04007 67 Targets of MicroRNA TCCAGAT MIR-516-5P www.broad.mit.e... MIR-516-5P...
Broad TGTATGA MIR-485-3P View Gene Set 0.01215 116 0.04007 67 Targets of MicroRNA TGTATGA MIR-485-3P www.broad.mit.e... MIR-485-3P...
Broad ATGCAGT MIR-217 View Gene Set 0.01282 93 0.04105 69 Targets of MicroRNA ATGCAGT MIR-217 www.broad.mit.e... MIR-217...
Broad TCTATGA MIR-376A MIR-376B View Gene Set 0.01337 71 0.04162 70 Targets of MicroRNA TCTATGA MIR-376A MIR-376B www.broad.mit.e... MIR-376A... MIR-376B...
Broad CTTTGCA MIR-527 View Gene Set 0.01325 198 0.04162 70 Targets of MicroRNA CTTTGCA MIR-527 www.broad.mit.e... MIR-527...
Broad ATAGGAA MIR-202 View Gene Set 0.01519 86 0.04661 72 Targets of MicroRNA ATAGGAA MIR-202 www.broad.mit.e... MIR-202...
Broad TCATCTC MIR-143 View Gene Set 0.01594 126 0.04825 73 Targets of MicroRNA TCATCTC MIR-143 www.broad.mit.e... MIR-143...
Broad CTATGCA MIR-153 View Gene Set 0.01694 182 0.04906 74 Targets of MicroRNA CTATGCA MIR-153 www.broad.mit.e... MIR-153...
Broad TCTAGAG MIR-517 View Gene Set 0.0165 37 0.04906 74 Targets of MicroRNA TCTAGAG MIR-517 www.broad.mit.e... MIR-517...
Broad GAGCCAG MIR-149 View Gene Set 0.01673 125 0.04906 74 Targets of MicroRNA GAGCCAG MIR-149 www.broad.mit.e... MIR-149...
Broad TAATAAT MIR-126 View Gene Set 0.01709 190 0.04906 74 Targets of MicroRNA TAATAAT MIR-126 www.broad.mit.e... MIR-126...

Gene Set Collection: Broad.c3.TFT

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad SCGGAAGY_V$ELK1_02 View Gene Set 3.158e-43 784 1.942e-40 1 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SCGGAAGY which matches annotation for ELK1: ELK1 member of ETS oncogene family www.broad.mit.e...
Broad RCGCANGCGY_V$NRF1_Q6 View Gene Set 1.932e-33 580 5.941e-31 2 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif RCGCANGCGY which matches annotation for NRF1: nuclear respiratory factor 1 www.broad.mit.e...
Broad GCCATNTTG_V$YY1_Q6 View Gene Set 4.064e-27 289 8.332e-25 3 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCATNTTG which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad GGGCGGR_V$SP1_Q6 View Gene Set 3.253e-21 2120 5.001e-19 4 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GGGCGGR which matches annotation for SP1: Sp1 transcription factor www.broad.mit.e...
Broad V$NFMUE1_Q6 View Gene Set 5.183e-19 175 6.375e-17 5 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CGGCCATCT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$YY1_Q6 View Gene Set 4.54e-17 166 4.653e-15 6 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCATNTTN which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad CACGTG_V$MYC_Q2 View Gene Set 3.762e-16 734 3.305e-14 7 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CACGTG which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian) www.broad.mit.e...
Broad MGGAAGTG_V$GABP_B View Gene Set 1.925e-13 512 1.48e-11 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif MGGAAGTG which matches annotation for GABPA: GA binding protein transcription factor alpha subunit 60kDa<br> GABPB2: GA binding protein transcription factor beta subunit 2 www.broad.mit.e...
Broad V$E2F1_Q6_01 View Gene Set 2.868e-13 177 1.764e-11 9 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTTTCGCGCS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad TGCGCANK_UNKNOWN View Gene Set 2.651e-13 361 1.764e-11 9 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TGCGCANK. Motif does not match any known transcription factor www.broad.mit.e...
Broad TMTCGCGANR_UNKNOWN View Gene Set 1.837e-12 100 1.027e-10 11 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TMTCGCGANR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$YY1_02 View Gene Set 4.462e-12 168 2.287e-10 12 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNCGGCCATCTTGNCTSNW which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad SGCGSSAAA_V$E2F1DP2_01 View Gene Set 1.235e-11 122 5.843e-10 13 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SGCGSSAAA which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad GGCNKCCATNK_UNKNOWN View Gene Set 1.596e-11 84 7.009e-10 14 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNKCCATNK. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$GABP_B View Gene Set 8.281e-11 162 3.25e-09 15 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif VCCGGAAGNGCR which matches annotation for GABPA: GA binding protein transcription factor alpha subunit 60kDa<br> GABPB2: GA binding protein transcription factor beta subunit 2 www.broad.mit.e...
Broad V$E2F1_Q6 View Gene Set 8.454e-11 167 3.25e-09 15 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$NRF2_01 View Gene Set 9.231e-11 166 3.339e-09 17 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif ACCGGAAGNG which matches annotation for GABPB1: GA binding protein transcription factor beta subunit 1. www.broad.mit.e...
Broad V$E2F_Q4 View Gene Set 1.458e-10 166 4.72e-09 18 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_03 View Gene Set 1.385e-10 171 4.72e-09 18 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGCGMNR. Motif does not match any known transcription factor www.broad.mit.e...
Broad KCCGNSWTTT_UNKNOWN View Gene Set 1.582e-10 76 4.865e-09 20 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif KCCGNSWTTT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$ELK1_02 View Gene Set 1.678e-10 170 4.914e-09 21 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNCCGGAARTNN which matches annotation for ELK1: ELK1 member of ETS oncogene family www.broad.mit.e...
Broad ACTAYRNNNCCCR_UNKNOWN View Gene Set 2.023e-10 293 5.656e-09 22 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ACTAYRNNNCCCR. Motif does not match any known transcription factor www.broad.mit.e...
Broad GATTGGY_V$NFY_Q6_01 View Gene Set 2.586e-10 830 6.914e-09 23 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GATTGGY. Motif does not match any known transcription factor www.broad.mit.e...
Broad GGCNNMSMYNTTG_UNKNOWN View Gene Set 4.497e-10 56 1.152e-08 24 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNNMSMYNTTG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q6 View Gene Set 8.181e-10 165 2.012e-08 25 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_02 View Gene Set 1.332e-09 169 3.15e-08 26 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1DP1_01 View Gene Set 1.716e-09 169 3.638e-08 27 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1DP2_01 View Gene Set 1.716e-09 169 3.638e-08 27 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F4DP2_01 View Gene Set 1.716e-09 169 3.638e-08 27 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F_Q3_01 View Gene Set 2.231e-09 171 4.427e-08 30 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1_Q4_01 View Gene Set 2.21e-09 167 4.427e-08 30 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$MYCMAX_01 View Gene Set 3.162e-09 189 6.077e-08 32 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNACCACGTGGTNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad TAANNYSGCG_UNKNOWN View Gene Set 1.662e-08 60 3.098e-07 33 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TAANNYSGCG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F4DP1_01 View Gene Set 3.675e-08 174 6.647e-07 34 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$NRF1_Q6 View Gene Set 4.824e-08 151 8.477e-07 35 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CGCATGCGCR which matches annotation for NRF1: nuclear respiratory factor 1 www.broad.mit.e...
Broad V$E2F1DP1RB_01 View Gene Set 7.629e-08 168 1.303e-06 36 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad V$E2F_Q4_01 View Gene Set 1.346e-07 171 2.237e-06 37 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad TCCCRNNRTGC_UNKNOWN View Gene Set 1.472e-07 130 2.383e-06 38 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TCCCRNNRTGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q3 View Gene Set 1.673e-07 176 2.638e-06 39 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKTSSCGC which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$E2F_Q3 View Gene Set 2.054e-07 162 3.158e-06 40 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTCGCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q6_01 View Gene Set 4.353e-07 167 6.529e-06 41 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKCGCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad ACAWNRNSRCGG_UNKNOWN View Gene Set 8.355e-07 50 1.223e-05 42 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ACAWNRNSRCGG. Motif does not match any known transcription factor www.broad.mit.e...
Broad RRCCGTTA_UNKNOWN View Gene Set 9.59e-07 53 1.372e-05 43 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif RRCCGTTA. Motif does not match any known transcription factor www.broad.mit.e...
Broad GTGACGY_V$E4F1_Q6 View Gene Set 1.282e-06 462 1.792e-05 44 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GTGACGY which matches annotation for E4F1: E4F transcription factor 1 www.broad.mit.e...
Broad V$MAX_01 View Gene Set 1.901e-06 194 2.598e-05 45 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNANCACGTGNTNN which matches annotation for MAX: MYC associated factor X www.broad.mit.e...
Broad V$USF_C View Gene Set 2.136e-06 211 2.855e-05 46 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NCACGTGN. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$CETS1P54_01 View Gene Set 2.439e-06 183 3.127e-05 47 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCMGGAWGYN which matches annotation for ETS1: v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) www.broad.mit.e...
Broad GATGKMRGCG_UNKNOWN View Gene Set 2.44e-06 47 3.127e-05 47 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GATGKMRGCG. Motif does not match any known transcription factor www.broad.mit.e...
Broad YGCGYRCGC_UNKNOWN View Gene Set 2.92e-06 207 3.665e-05 49 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif YGCGYRCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$ARNT_02 View Gene Set 5.851e-06 179 7.197e-05 50 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNRTCACGTGAYNNNNN which matches annotation for ARNT: aryl hydrocarbon receptor nuclear translocator www.broad.mit.e...
Broad GCGNNANTTCC_UNKNOWN View Gene Set 8.042e-06 85 9.685e-05 51 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GCGNNANTTCC. Motif does not match any known transcription factor www.broad.mit.e...
Broad GCGSCMNTTT_UNKNOWN View Gene Set 8.189e-06 49 9.685e-05 51 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GCGSCMNTTT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_01 View Gene Set 1.292e-05 55 0.00015 53 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TWSGCGCGAAAAYKR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF_01 View Gene Set 1.348e-05 186 0.0001536 54 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNRYCACGTGRYNN. Motif does not match any known transcription factor www.broad.mit.e...
Broad GGCNRNWCTTYS_UNKNOWN View Gene Set 1.878e-05 52 0.00021 55 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNRNWCTTYS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$YY1_01 View Gene Set 2.819e-05 190 0.0003041 56 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNCCATNTWNNNWN which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad TTCNRGNNNNTTC_V$HSF_Q6 View Gene Set 2.782e-05 111 0.0003041 56 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTCNRGNNNNTTC. Motif does not match any known transcription factor www.broad.mit.e...
Broad AAGWWRNYGGC_UNKNOWN View Gene Set 3.004e-05 85 0.0003185 58 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif AAGWWRNYGGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad CCGNMNNTNACG_UNKNOWN View Gene Set 4.149e-05 56 0.0004253 59 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CCGNMNNTNACG. Motif does not match any known transcription factor www.broad.mit.e...
Broad GGAANCGGAANY_UNKNOWN View Gene Set 4.122e-05 79 0.0004253 59 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGAANCGGAANY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$ARNT_01 View Gene Set 4.285e-05 196 0.000432 61 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NDDNNCACGTGNNNNN which matches annotation for ARNT: aryl hydrocarbon receptor nuclear translocator www.broad.mit.e...
Broad GKCGCNNNNNNNTGAYG_UNKNOWN View Gene Set 4.856e-05 41 0.0004816 62 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GKCGCNNNNNNNTGAYG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q4 View Gene Set 8.323e-05 178 0.0008125 63 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTTSGCGG which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$USF2_Q6 View Gene Set 8.896e-05 182 0.0008549 64 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CASGYG. Motif does not match any known transcription factor www.broad.mit.e...
Broad CRGAARNNNNCGA_UNKNOWN View Gene Set 9.69e-05 34 0.0009169 65 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CRGAARNNNNCGA. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$HIF1_Q3 View Gene Set 0.0001016 161 0.0009472 66 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GNNKACGTGCGGNN which matches annotation for HIF1A: hypoxia-inducible factor 1 alpha subunit (basic helix-loop-helix transcription factor) www.broad.mit.e...
Broad V$TEL2_Q6 View Gene Set 0.0001067 158 0.0009795 67 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif YTACTTCCTG which matches annotation for ETV7: ets variant gene 7 (TEL2 oncogene) www.broad.mit.e...
Broad V$CMYB_01 View Gene Set 0.0001173 179 0.001061 68 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCNRNNGRCNGTTGGKGG which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) www.broad.mit.e...
Broad V$NMYC_01 View Gene Set 0.000185 201 0.001649 69 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNCCACGTGNNN which matches annotation for MYCN: v-myc myelocytomatosis viral related oncogene neuroblastoma derived (avian) www.broad.mit.e...
Broad V$SREBP1_01 View Gene Set 0.0002022 133 0.001776 70 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NATCACGTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 www.broad.mit.e...
Broad V$STAT1_02 View Gene Set 0.0002842 179 0.002462 71 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CANTTCCS which matches annotation for STAT1: signal transducer and activator of transcription 1 91kDa www.broad.mit.e...
Broad V$USF_Q6_01 View Gene Set 0.0003204 168 0.002737 72 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NRCCACGTGASN. Motif does not match any known transcription factor www.broad.mit.e...
Broad ATGGYGGA_UNKNOWN View Gene Set 0.0005853 68 0.004931 73 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ATGGYGGA. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$NFY_Q6_01 View Gene Set 0.001178 185 0.009794 74 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNNNRRCCAATSR. Motif does not match any known transcription factor www.broad.mit.e...
Broad TTCYRGAA_UNKNOWN View Gene Set 0.001321 221 0.01083 75 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTCYRGAA. Motif does not match any known transcription factor www.broad.mit.e...
Broad TCANNTGAY_V$SREBP1_01 View Gene Set 0.001353 355 0.01095 76 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TCANNTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 www.broad.mit.e...
Broad GGGNRMNNYCAT_UNKNOWN View Gene Set 0.001461 61 0.01167 77 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGGNRMNNYCAT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$MYC_Q2 View Gene Set 0.001553 135 0.01225 78 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CACGTGS which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian) www.broad.mit.e...
Broad CCAWNWWNNNGGC_UNKNOWN View Gene Set 0.001968 56 0.01532 79 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CCAWNWWNNNGGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF_02 View Gene Set 0.002452 197 0.01839 80 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNRNCACGTGNYNN. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF_Q6 View Gene Set 0.002452 178 0.01839 80 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GYCACGTGNC. Motif does not match any known transcription factor www.broad.mit.e...
Broad KTGGYRSGAA_UNKNOWN View Gene Set 0.002439 53 0.01839 80 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif KTGGYRSGAA. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$CREB_02 View Gene Set 0.002648 185 0.01962 83 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNGNTGACGTNN which matches annotation for CREB1: cAMP responsive element binding protein 1 www.broad.mit.e...
Broad V$MYCMAX_B View Gene Set 0.002783 193 0.02037 84 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCAYGYGSN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad V$NFY_C View Gene Set 0.003814 179 0.0276 85 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NCTGATTGGYTASY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$MYCMAX_03 View Gene Set 0.0058 187 0.04148 86 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNNNCACGTGNNNNNNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad CGGAARNGGCNG_UNKNOWN View Gene Set 0.006045 33 0.04273 87 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CGGAARNGGCNG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$AHR_Q5 View Gene Set 0.006525 153 0.0456 88 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTNGCGTGNNN which matches annotation for AHR: aryl hydrocarbon receptor www.broad.mit.e...
Broad ATCMNTCCGY_UNKNOWN View Gene Set 0.006978 36 0.04769 89 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ATCMNTCCGY. Motif does not match any known transcription factor www.broad.mit.e...
Broad SMTTTTGT_UNKNOWN View Gene Set 0.006914 319 0.04769 89 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif SMTTTTGT. Motif does not match any known transcription factor www.broad.mit.e...

Gene Set Collection: Broad.c4.CGN

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad MORF_RAD23A View Gene Set 1.71e-85 316 7.304e-83 1 Neighborhood of RAD23A www.broad.mit.e...
Broad MORF_BUB3 View Gene Set 2.635e-77 256 5.627e-75 2 Neighborhood of BUB3 www.broad.mit.e...
Broad MORF_GNB1 View Gene Set 3.251e-72 276 4.627e-70 3 Neighborhood of GNB1 www.broad.mit.e...
Broad MORF_RAN View Gene Set 6.356e-69 242 6.785e-67 4 Neighborhood of RAN www.broad.mit.e...
Broad MORF_HDAC2 View Gene Set 6.837e-67 256 5.839e-65 5 Neighborhood of HDAC2 www.broad.mit.e...
Broad MORF_CSNK2B View Gene Set 3.438e-65 256 2.447e-63 6 Neighborhood of CSNK2B www.broad.mit.e...
Broad MORF_DEK View Gene Set 6.422e-65 229 3.917e-63 7 Neighborhood of DEK www.broad.mit.e...
Broad MORF_SOD1 View Gene Set 1.477e-64 247 7.884e-63 8 Neighborhood of SOD1 www.broad.mit.e...
Broad MORF_UBE2I View Gene Set 1.229e-62 208 5.833e-61 9 Neighborhood of UBE2I www.broad.mit.e...
Broad MORF_HDAC1 View Gene Set 8.696e-62 222 3.713e-60 10 Neighborhood of HDAC1 www.broad.mit.e...
Broad MORF_EIF3S2 View Gene Set 3.044e-60 220 1.182e-58 11 Neighborhood of EIF3S2 www.broad.mit.e...
Broad MORF_XRCC5 View Gene Set 2.501e-58 210 8.9e-57 12 Neighborhood of XRCC5 www.broad.mit.e...
Broad MORF_ANP32B View Gene Set 1.983e-52 174 6.514e-51 13 Neighborhood of ANP32B www.broad.mit.e...
Broad MORF_ACP1 View Gene Set 2.373e-51 178 7.237e-50 14 Neighborhood of ACP1 www.broad.mit.e...
Broad MORF_DAP3 View Gene Set 6.46e-50 175 1.839e-48 15 Neighborhood of DAP3 www.broad.mit.e...
Broad MORF_PRKDC View Gene Set 2.876e-48 173 7.675e-47 16 Neighborhood of PRKDC www.broad.mit.e...
Broad MORF_AATF View Gene Set 1.042e-47 179 2.617e-46 17 Neighborhood of AATF www.broad.mit.e...
Broad MORF_NPM1 View Gene Set 1.768e-47 152 4.194e-46 18 Neighborhood of NPM1 www.broad.mit.e...
Broad MORF_HAT1 View Gene Set 9.734e-47 155 2.188e-45 19 Neighborhood of HAT1 www.broad.mit.e...
Broad MORF_G22P1 View Gene Set 8.043e-45 145 1.717e-43 20 Neighborhood of G22P1 www.broad.mit.e...
Broad MORF_PPP1CC View Gene Set 1.205e-44 150 2.45e-43 21 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_CTBP1 View Gene Set 2.15e-44 149 4.174e-43 22 Neighborhood of CTBP1 www.broad.mit.e...
Broad MORF_RAD21 View Gene Set 1.538e-43 157 2.855e-42 23 Neighborhood of RAD21 www.broad.mit.e...
Broad MORF_AP2M1 View Gene Set 2.603e-43 197 4.631e-42 24 Neighborhood of AP2M1 www.broad.mit.e...
Broad MORF_FBL View Gene Set 3.711e-42 121 6.339e-41 25 Neighborhood of FBL www.broad.mit.e...
Broad MORF_PRKAG1 View Gene Set 6.389e-42 202 1.049e-40 26 Neighborhood of PRKAG1 www.broad.mit.e...
Broad MORF_EI24 View Gene Set 9.904e-42 136 1.566e-40 27 Neighborhood of EI24 www.broad.mit.e...
Broad MORF_NME2 View Gene Set 2.117e-41 145 3.228e-40 28 Neighborhood of NME2 www.broad.mit.e...
Broad MORF_SKP1A View Gene Set 4.863e-41 175 7.161e-40 29 Neighborhood of SKP1A www.broad.mit.e...
Broad MORF_RFC4 View Gene Set 1.299e-40 137 1.849e-39 30 Neighborhood of RFC4 www.broad.mit.e...
Broad MORF_ACTG1 View Gene Set 7.532e-40 134 1.038e-38 31 Neighborhood of ACTG1 www.broad.mit.e...
Broad MORF_RAC1 View Gene Set 8.374e-40 196 1.117e-38 32 Neighborhood of RAC1 www.broad.mit.e...
Broad GNF2_FBL View Gene Set 1.2e-39 119 1.553e-38 33 Neighborhood of FBL www.broad.mit.e...
Broad MORF_PPP1CA View Gene Set 3.014e-37 145 3.785e-36 34 Neighborhood of PPP1CA www.broad.mit.e...
Broad MORF_DDB1 View Gene Set 5.919e-37 220 7.221e-36 35 Neighborhood of DDB1 www.broad.mit.e...
Broad GCM_APEX1 View Gene Set 6.21e-37 102 7.366e-36 36 Neighborhood of APEX1 www.broad.mit.e...
Broad MORF_EIF4A2 View Gene Set 6.144e-36 120 7.091e-35 37 Neighborhood of EIF4A2 www.broad.mit.e...
Broad MORF_RAD23B View Gene Set 6.929e-35 159 7.786e-34 38 Neighborhood of RAD23B www.broad.mit.e...
Broad MORF_PSMC1 View Gene Set 1.164e-33 162 1.274e-32 39 Neighborhood of PSMC1 www.broad.mit.e...
Broad MORF_DNMT1 View Gene Set 3.996e-33 105 4.266e-32 40 Neighborhood of DNMT1 www.broad.mit.e...
Broad MORF_ERH View Gene Set 5.082e-33 103 5.292e-32 41 Neighborhood of ERH www.broad.mit.e...
Broad MORF_EIF3S6 View Gene Set 8.587e-33 108 8.73e-32 42 Neighborhood of EIF3S6 www.broad.mit.e...
Broad MORF_PRKAR1A View Gene Set 1.139e-32 133 1.131e-31 43 Neighborhood of PRKAR1A www.broad.mit.e...
Broad GNF2_EIF3S6 View Gene Set 1.364e-32 109 1.324e-31 44 Neighborhood of EIF3S6 www.broad.mit.e...
Broad GNF2_RRM1 View Gene Set 1.793e-32 82 1.702e-31 45 Neighborhood of RRM1 www.broad.mit.e...
Broad MORF_RPA2 View Gene Set 2.3e-32 170 2.135e-31 46 Neighborhood of RPA2 www.broad.mit.e...
Broad GCM_ACTG1 View Gene Set 8.742e-32 113 7.942e-31 47 Neighborhood of ACTG1 www.broad.mit.e...
Broad MORF_AP3D1 View Gene Set 4.403e-31 119 3.917e-30 48 Neighborhood of AP3D1 www.broad.mit.e...
Broad GCM_NPM1 View Gene Set 9.966e-31 108 8.684e-30 49 Neighborhood of NPM1 www.broad.mit.e...
Broad GNF2_PA2G4 View Gene Set 1.073e-30 73 9.164e-30 50 Neighborhood of PA2G4 www.broad.mit.e...
Broad GNF2_RAN View Gene Set 5.154e-30 78 4.316e-29 51 Neighborhood of RAN www.broad.mit.e...
Broad MORF_PCNA View Gene Set 1.053e-29 71 8.646e-29 52 Neighborhood of PCNA www.broad.mit.e...
Broad GCM_CSNK2B View Gene Set 1.668e-29 88 1.344e-28 53 Neighborhood of CSNK2B www.broad.mit.e...
Broad MORF_RRM1 View Gene Set 1.771e-29 90 1.4e-28 54 Neighborhood of RRM1 www.broad.mit.e...
Broad MORF_RAB1A View Gene Set 6.78e-29 179 5.264e-28 55 Neighborhood of RAB1A www.broad.mit.e...
Broad MORF_PPP2CA View Gene Set 1.34e-28 110 1.022e-27 56 Neighborhood of PPP2CA www.broad.mit.e...
Broad MORF_TPT1 View Gene Set 1.904e-28 100 1.426e-27 57 Neighborhood of TPT1 www.broad.mit.e...
Broad MORF_MAP2K2 View Gene Set 2.132e-28 123 1.57e-27 58 Neighborhood of MAP2K2 www.broad.mit.e...
Broad GNF2_DAP3 View Gene Set 2.549e-28 98 1.845e-27 59 Neighborhood of DAP3 www.broad.mit.e...
Broad GNF2_SMC4L1 View Gene Set 1.262e-27 75 8.983e-27 60 Neighborhood of SMC4L1 www.broad.mit.e...
Broad GNF2_CCNA2 View Gene Set 3.662e-27 62 2.563e-26 61 Neighborhood of CCNA2 www.broad.mit.e...
Broad MORF_PAPSS1 View Gene Set 9.876e-27 98 6.802e-26 62 Neighborhood of PAPSS1 www.broad.mit.e...
Broad GNF2_CDC20 View Gene Set 1.134e-26 52 7.689e-26 63 Neighborhood of CDC20 www.broad.mit.e...
Broad MORF_CCNI View Gene Set 1.223e-26 76 8.16e-26 64 Neighborhood of CCNI www.broad.mit.e...
Broad GNF2_APEX1 View Gene Set 3.516e-26 72 2.31e-25 65 Neighborhood of APEX1 www.broad.mit.e...
Broad GNF2_CCNB2 View Gene Set 3.772e-26 53 2.44e-25 66 Neighborhood of CCNB2 www.broad.mit.e...
Broad MORF_CDC10 View Gene Set 1.868e-24 120 1.19e-23 67 Neighborhood of CDC10 www.broad.mit.e...
Broad GNF2_CENPF View Gene Set 2.207e-24 56 1.386e-23 68 Neighborhood of CENPF www.broad.mit.e...
Broad MORF_RAD54L View Gene Set 3.135e-24 94 1.94e-23 69 Neighborhood of RAD54L www.broad.mit.e...
Broad MORF_UBE2N View Gene Set 4.906e-24 79 2.993e-23 70 Neighborhood of UBE2N www.broad.mit.e...
Broad GNF2_PCNA View Gene Set 9.503e-24 62 5.715e-23 71 Neighborhood of PCNA www.broad.mit.e...
Broad MORF_UNG View Gene Set 1.226e-23 65 7.27e-23 72 Neighborhood of UNG www.broad.mit.e...
Broad GCM_PSME1 View Gene Set 1.314e-23 76 7.683e-23 73 Neighborhood of PSME1 www.broad.mit.e...
Broad MORF_ESPL1 View Gene Set 2.476e-23 58 1.429e-22 74 Neighborhood of ESPL1 www.broad.mit.e...
Broad MORF_PTPN11 View Gene Set 4.267e-23 93 2.429e-22 75 Neighborhood of PTPN11 www.broad.mit.e...
Broad GNF2_CDC2 View Gene Set 5.893e-23 56 3.311e-22 76 Neighborhood of CDC2 www.broad.mit.e...
Broad MORF_SP3 View Gene Set 6.142e-23 69 3.406e-22 77 Neighborhood of SP3 www.broad.mit.e...
Broad MORF_PSMC2 View Gene Set 7.019e-23 100 3.842e-22 78 Neighborhood of PSMC2 www.broad.mit.e...
Broad MORF_MTA1 View Gene Set 1.504e-22 95 8.131e-22 79 Neighborhood of MTA1 www.broad.mit.e...
Broad GNF2_MCM4 View Gene Set 2.283e-22 50 1.219e-21 80 Neighborhood of MCM4 www.broad.mit.e...
Broad MORF_FEN1 View Gene Set 6.723e-22 58 3.544e-21 81 Neighborhood of FEN1 www.broad.mit.e...
Broad GCM_TPT1 View Gene Set 8.595e-22 69 4.476e-21 82 Neighborhood of TPT1 www.broad.mit.e...
Broad GNF2_BUB1B View Gene Set 1.045e-21 46 5.376e-21 83 Neighborhood of BUB1B www.broad.mit.e...
Broad MORF_RAF1 View Gene Set 1.147e-21 94 5.829e-21 84 Neighborhood of RAF1 www.broad.mit.e...
Broad GCM_CBFB View Gene Set 3.918e-21 59 1.968e-20 85 Neighborhood of CBFB www.broad.mit.e...
Broad GNF2_HMMR View Gene Set 5.894e-21 43 2.927e-20 86 Neighborhood of HMMR www.broad.mit.e...
Broad MORF_PRDX3 View Gene Set 6.39e-21 79 3.136e-20 87 Neighborhood of PRDX3 www.broad.mit.e...
Broad GNF2_RFC4 View Gene Set 1.552e-20 57 7.531e-20 88 Neighborhood of RFC4 www.broad.mit.e...
Broad GNF2_NPM1 View Gene Set 2.16e-20 57 1.036e-19 89 Neighborhood of NPM1 www.broad.mit.e...
Broad MORF_CDC16 View Gene Set 2.532e-20 67 1.201e-19 90 Neighborhood of CDC16 www.broad.mit.e...
Broad GNF2_MCM5 View Gene Set 5.78e-20 51 2.712e-19 91 Neighborhood of MCM5 www.broad.mit.e...
Broad MORF_BUB1 View Gene Set 7.137e-20 49 3.313e-19 92 Neighborhood of BUB1 www.broad.mit.e...
Broad GNF2_CKS2 View Gene Set 9.834e-20 45 4.515e-19 93 Neighborhood of CKS2 www.broad.mit.e...
Broad GNF2_ESPL1 View Gene Set 1.266e-19 35 5.751e-19 94 Neighborhood of ESPL1 www.broad.mit.e...
Broad GNF2_HAT1 View Gene Set 1.515e-19 45 6.812e-19 95 Neighborhood of HAT1 www.broad.mit.e...
Broad MORF_JUND View Gene Set 2.309e-19 63 1.027e-18 96 Neighborhood of JUND www.broad.mit.e...
Broad MORF_SMC1L1 View Gene Set 5.559e-19 47 2.447e-18 97 Neighborhood of SMC1L1 www.broad.mit.e...
Broad GNF2_FEN1 View Gene Set 1.527e-18 49 6.655e-18 98 Neighborhood of FEN1 www.broad.mit.e...
Broad GNF2_ST13 View Gene Set 2.471e-18 56 1.066e-17 99 Neighborhood of ST13 www.broad.mit.e...
Broad MORF_PHB View Gene Set 2.612e-18 112 1.115e-17 100 Neighborhood of PHB www.broad.mit.e...
Broad GNF2_RRM2 View Gene Set 4.698e-18 36 1.986e-17 101 Neighborhood of RRM2 www.broad.mit.e...
Broad MORF_BUB1B View Gene Set 5.254e-18 61 2.199e-17 102 Neighborhood of BUB1B www.broad.mit.e...
Broad GNF2_CENPE View Gene Set 6.193e-18 37 2.567e-17 103 Neighborhood of CENPE www.broad.mit.e...
Broad GNF2_RFC3 View Gene Set 6.373e-18 38 2.617e-17 104 Neighborhood of RFC3 www.broad.mit.e...
Broad MORF_RPA1 View Gene Set 6.935e-18 55 2.82e-17 105 Neighborhood of RPA1 www.broad.mit.e...
Broad MORF_CUL1 View Gene Set 8.595e-18 62 3.462e-17 106 Neighborhood of CUL1 www.broad.mit.e...
Broad MORF_CDK2 View Gene Set 1.029e-17 63 4.107e-17 107 Neighborhood of CDK2 www.broad.mit.e...
Broad MORF_MSH2 View Gene Set 1.83e-17 52 7.237e-17 108 Neighborhood of MSH2 www.broad.mit.e...
Broad MORF_RAB6A View Gene Set 1.895e-17 63 7.422e-17 109 Neighborhood of RAB6A www.broad.mit.e...
Broad GNF2_DEK View Gene Set 2.207e-17 45 8.566e-17 110 Neighborhood of DEK www.broad.mit.e...
Broad GNF2_CKS1B View Gene Set 2.316e-17 36 8.909e-17 111 Neighborhood of CKS1B www.broad.mit.e...
Broad GCM_PPP1CC View Gene Set 4.098e-17 47 1.562e-16 112 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_ATOX1 View Gene Set 9.357e-17 72 3.536e-16 113 Neighborhood of ATOX1 www.broad.mit.e...
Broad GCM_DDX5 View Gene Set 1.217e-16 52 4.559e-16 114 Neighborhood of DDX5 www.broad.mit.e...
Broad GNF2_XRCC5 View Gene Set 1.386e-16 61 5.147e-16 115 Neighborhood of XRCC5 www.broad.mit.e...
Broad MORF_SART1 View Gene Set 3.528e-16 55 1.299e-15 116 Neighborhood of SART1 www.broad.mit.e...
Broad MORF_MBD4 View Gene Set 4.336e-16 76 1.583e-15 117 Neighborhood of MBD4 www.broad.mit.e...
Broad MORF_TERF2IP View Gene Set 5.203e-16 99 1.883e-15 118 Neighborhood of TERF2IP www.broad.mit.e...
Broad GNF2_H2AFX View Gene Set 5.795e-16 28 2.079e-15 119 Neighborhood of H2AFX www.broad.mit.e...
Broad MORF_GMPS View Gene Set 7.018e-16 48 2.497e-15 120 Neighborhood of GMPS www.broad.mit.e...
Broad GCM_DFFA View Gene Set 7.228e-16 100 2.551e-15 121 Neighborhood of DFFA www.broad.mit.e...
Broad GCM_NF2 View Gene Set 2.05e-15 235 7.174e-15 122 Neighborhood of NF2 www.broad.mit.e...
Broad GNF2_TTK View Gene Set 2.445e-15 34 8.489e-15 123 Neighborhood of TTK www.broad.mit.e...
Broad GNF2_HDAC1 View Gene Set 3.15e-15 85 1.085e-14 124 Neighborhood of HDAC1 www.broad.mit.e...
Broad GNF2_MLH1 View Gene Set 9.606e-15 36 3.282e-14 125 Neighborhood of MLH1 www.broad.mit.e...
Broad MORF_DEAF1 View Gene Set 1.175e-14 54 3.983e-14 126 Neighborhood of DEAF1 www.broad.mit.e...
Broad MORF_EIF4E View Gene Set 1.671e-14 76 5.619e-14 127 Neighborhood of EIF4E www.broad.mit.e...
Broad MORF_TERF1 View Gene Set 2.346e-14 57 7.828e-14 128 Neighborhood of TERF1 www.broad.mit.e...
Broad GNF2_MKI67 View Gene Set 2.463e-14 26 8.154e-14 129 Neighborhood of MKI67 www.broad.mit.e...
Broad GCM_PFN1 View Gene Set 4.395e-14 47 1.444e-13 130 Neighborhood of PFN1 www.broad.mit.e...
Broad MORF_RAB5A View Gene Set 5.243e-14 83 1.709e-13 131 Neighborhood of RAB5A www.broad.mit.e...
Broad GCM_ANP32B View Gene Set 5.693e-14 32 1.842e-13 132 Neighborhood of ANP32B www.broad.mit.e...
Broad GCM_UBE2N View Gene Set 6.436e-14 125 2.066e-13 133 Neighborhood of UBE2N www.broad.mit.e...
Broad MORF_GSPT1 View Gene Set 7.308e-14 41 2.329e-13 134 Neighborhood of GSPT1 www.broad.mit.e...
Broad MORF_BAG5 View Gene Set 9.756e-14 48 3.086e-13 135 Neighborhood of BAG5 www.broad.mit.e...
Broad GCM_MYST2 View Gene Set 1.218e-13 138 3.796e-13 136 Neighborhood of MYST2 www.broad.mit.e...
Broad GCM_RAF1 View Gene Set 1.216e-13 34 3.796e-13 136 Neighborhood of RAF1 www.broad.mit.e...
Broad GCM_RAB10 View Gene Set 2.353e-13 143 7.28e-13 138 Neighborhood of RAB10 www.broad.mit.e...
Broad GNF2_RBBP6 View Gene Set 2.434e-13 54 7.478e-13 139 Neighborhood of RBBP6 www.broad.mit.e...
Broad GNF2_KPNB1 View Gene Set 3.233e-13 52 9.862e-13 140 Neighborhood of KPNB1 www.broad.mit.e...
Broad MORF_BMI1 View Gene Set 3.453e-13 71 1.046e-12 141 Neighborhood of BMI1 www.broad.mit.e...
Broad GNF2_SMC2L1 View Gene Set 4.159e-13 30 1.251e-12 142 Neighborhood of SMC2L1 www.broad.mit.e...
Broad GCM_GSPT1 View Gene Set 5.882e-13 129 1.756e-12 143 Neighborhood of GSPT1 www.broad.mit.e...
Broad MORF_DAP View Gene Set 6.367e-13 72 1.888e-12 144 Neighborhood of DAP www.broad.mit.e...
Broad GCM_RAD21 View Gene Set 7.827e-13 30 2.305e-12 145 Neighborhood of RAD21 www.broad.mit.e...
Broad MORF_SNRP70 View Gene Set 8.212e-13 50 2.402e-12 146 Neighborhood of SNRP70 www.broad.mit.e...
Broad GNF2_DENR View Gene Set 8.27e-13 39 2.402e-12 147 Neighborhood of DENR www.broad.mit.e...
Broad MORF_PPP2R4 View Gene Set 1.51e-12 44 4.355e-12 148 Neighborhood of PPP2R4 www.broad.mit.e...
Broad GNF2_NS View Gene Set 1.596e-12 35 4.572e-12 149 Neighborhood of NS www.broad.mit.e...
Broad MORF_XPC View Gene Set 2.17e-12 55 6.178e-12 150 Neighborhood of XPC www.broad.mit.e...
Broad MORF_PPP6C View Gene Set 2.201e-12 88 6.223e-12 151 Neighborhood of PPP6C www.broad.mit.e...
Broad GNF2_BUB1 View Gene Set 4.671e-12 25 1.312e-11 152 Neighborhood of BUB1 www.broad.mit.e...
Broad MORF_USP5 View Gene Set 1.36e-11 46 3.796e-11 153 Neighborhood of USP5 www.broad.mit.e...
Broad GNF2_TPT1 View Gene Set 1.374e-11 38 3.81e-11 154 Neighborhood of TPT1 www.broad.mit.e...
Broad GCM_HBP1 View Gene Set 2.13e-11 54 5.867e-11 155 Neighborhood of HBP1 www.broad.mit.e...
Broad MORF_PPP2R5E View Gene Set 2.468e-11 76 6.756e-11 156 Neighborhood of PPP2R5E www.broad.mit.e...
Broad GNF2_G22P1 View Gene Set 4.322e-11 29 1.175e-10 157 Neighborhood of G22P1 www.broad.mit.e...
Broad GNF2_UBE2I View Gene Set 5.085e-11 33 1.374e-10 158 Neighborhood of UBE2I www.broad.mit.e...
Broad GNF2_ANP32B View Gene Set 5.129e-11 29 1.377e-10 159 Neighborhood of ANP32B www.broad.mit.e...
Broad MORF_GPX4 View Gene Set 7.141e-11 49 1.906e-10 160 Neighborhood of GPX4 www.broad.mit.e...
Broad GNF2_MSH6 View Gene Set 1.242e-10 30 3.293e-10 161 Neighborhood of MSH6 www.broad.mit.e...
Broad MORF_TPR View Gene Set 2.698e-10 131 7.111e-10 162 Neighborhood of TPR www.broad.mit.e...
Broad GNF2_MSH2 View Gene Set 5.376e-10 26 1.408e-09 163 Neighborhood of MSH2 www.broad.mit.e...
Broad GNF2_BUB3 View Gene Set 5.922e-10 22 1.542e-09 164 Neighborhood of BUB3 www.broad.mit.e...
Broad MORF_BECN1 View Gene Set 7.115e-10 93 1.841e-09 165 Neighborhood of BECN1 www.broad.mit.e...
Broad MORF_CCNF View Gene Set 9.396e-10 65 2.417e-09 166 Neighborhood of CCNF www.broad.mit.e...
Broad MORF_UBE2A View Gene Set 1.866e-09 44 4.77e-09 167 Neighborhood of UBE2A www.broad.mit.e...
Broad GNF2_TDG View Gene Set 2.572e-09 23 6.537e-09 168 Neighborhood of TDG www.broad.mit.e...
Broad GCM_DENR View Gene Set 2.774e-09 40 7.01e-09 169 Neighborhood of DENR www.broad.mit.e...
Broad GCM_TPR View Gene Set 3.77e-09 29 9.471e-09 170 Neighborhood of TPR www.broad.mit.e...
Broad GCM_RAN View Gene Set 5.883e-09 160 1.469e-08 171 Neighborhood of RAN www.broad.mit.e...
Broad MORF_RFC1 View Gene Set 6.494e-09 98 1.612e-08 172 Neighborhood of RFC1 www.broad.mit.e...
Broad GCM_SMARCC1 View Gene Set 7.2e-09 33 1.777e-08 173 Neighborhood of SMARCC1 www.broad.mit.e...
Broad GCM_HDAC1 View Gene Set 9.933e-09 30 2.424e-08 174 Neighborhood of HDAC1 www.broad.mit.e...
Broad GNF2_GLTSCR2 View Gene Set 9.905e-09 31 2.424e-08 174 Neighborhood of GLTSCR2 www.broad.mit.e...
Broad GCM_CSNK1A1 View Gene Set 1.321e-08 28 3.204e-08 176 Neighborhood of CSNK1A1 www.broad.mit.e...
Broad GCM_MLL View Gene Set 1.941e-08 130 4.682e-08 177 Neighborhood of MLL www.broad.mit.e...
Broad GCM_BECN1 View Gene Set 4.887e-08 59 1.172e-07 178 Neighborhood of BECN1 www.broad.mit.e...
Broad GNF2_PPP6C View Gene Set 9.827e-08 33 2.344e-07 179 Neighborhood of PPP6C www.broad.mit.e...
Broad GCM_CHUK View Gene Set 1.566e-07 61 3.715e-07 180 Neighborhood of CHUK www.broad.mit.e...
Broad GCM_ZNF198 View Gene Set 3.509e-07 98 8.279e-07 181 Neighborhood of ZNF198 www.broad.mit.e...
Broad MORF_RAB11A View Gene Set 4.32e-07 53 1.014e-06 182 Neighborhood of RAB11A www.broad.mit.e...
Broad GCM_BCL2L1 View Gene Set 6.991e-07 25 1.631e-06 183 Neighborhood of BCL2L1 www.broad.mit.e...
Broad GCM_MAX View Gene Set 1.023e-06 28 2.374e-06 184 Neighborhood of MAX www.broad.mit.e...
Broad GNF2_SMC1L1 View Gene Set 1.291e-06 24 2.979e-06 185 Neighborhood of SMC1L1 www.broad.mit.e...
Broad GCM_ERBB2IP View Gene Set 2.527e-06 57 5.801e-06 186 Neighborhood of ERBB2IP www.broad.mit.e...
Broad GNF2_ELAC2 View Gene Set 2.848e-06 32 6.503e-06 187 Neighborhood of ELAC2 www.broad.mit.e...
Broad GCM_RBM8A View Gene Set 5.114e-06 64 1.161e-05 188 Neighborhood of RBM8A www.broad.mit.e...
Broad MORF_SS18 View Gene Set 5.158e-06 55 1.165e-05 189 Neighborhood of SS18 www.broad.mit.e...
Broad GCM_BMPR2 View Gene Set 5.667e-06 68 1.274e-05 190 Neighborhood of BMPR2 www.broad.mit.e...
Broad MORF_IKBKG View Gene Set 5.786e-06 119 1.294e-05 191 Neighborhood of IKBKG www.broad.mit.e...
Broad GCM_BAG5 View Gene Set 7.707e-06 26 1.714e-05 192 Neighborhood of BAG5 www.broad.mit.e...
Broad GCM_AIP View Gene Set 2.703e-05 36 5.95e-05 193 Neighborhood of AIP www.broad.mit.e...
Broad GNF2_RPA1 View Gene Set 2.695e-05 20 5.95e-05 193 Neighborhood of RPA1 www.broad.mit.e...
Broad GCM_CALM1 View Gene Set 4.707e-05 91 0.0001031 195 Neighborhood of CALM1 www.broad.mit.e...
Broad GCM_MSN View Gene Set 4.793e-05 24 0.0001044 196 Neighborhood of MSN www.broad.mit.e...
Broad GNF2_CBFB View Gene Set 5.049e-05 26 0.0001094 197 Neighborhood of CBFB www.broad.mit.e...
Broad GCM_SUFU View Gene Set 5.126e-05 62 0.0001105 198 Neighborhood of SUFU www.broad.mit.e...
Broad GCM_CRKL View Gene Set 9.234e-05 50 0.0001981 199 Neighborhood of CRKL www.broad.mit.e...
Broad GCM_ING1 View Gene Set 9.925e-05 50 0.0002119 200 Neighborhood of ING1 www.broad.mit.e...

Gene Set Collection: Broad.c4.CM

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad module_83 View Gene Set 9.898e-59 296 4.494e-56 1 Genes in module_83 www.broad.mit.e...
Broad module_32 View Gene Set 9.444e-52 227 2.144e-49 2 Genes in module_32 www.broad.mit.e...
Broad module_114 View Gene Set 1.582e-50 314 2.394e-48 3 Genes in module_114 www.broad.mit.e...
Broad module_151 View Gene Set 1.695e-47 297 1.923e-45 4 Genes in module_151 www.broad.mit.e...
Broad module_8 View Gene Set 4.218e-44 403 3.83e-42 5 Genes in module_8 www.broad.mit.e...
Broad module_54 View Gene Set 5.653e-39 242 4.277e-37 6 Genes in module_54 www.broad.mit.e...
Broad module_98 View Gene Set 7.369e-38 375 4.78e-36 7 Genes in module_98 www.broad.mit.e...
Broad module_198 View Gene Set 1.002e-37 288 5.688e-36 8 Genes in module_198 www.broad.mit.e...
Broad module_17 View Gene Set 6.233e-36 351 3.144e-34 9 Genes in module_17 www.broad.mit.e...
Broad module_252 View Gene Set 1.316e-32 224 5.973e-31 10 Genes in module_252 www.broad.mit.e...
Broad module_3 View Gene Set 1.863e-29 374 7.69e-28 11 Genes in module_3 www.broad.mit.e...
Broad module_124 View Gene Set 2.38e-21 92 9.004e-20 12 Genes in module_124 www.broad.mit.e...
Broad module_239 View Gene Set 2.908e-19 112 1.015e-17 13 Genes in module_239 www.broad.mit.e...
Broad module_244 View Gene Set 9.695e-19 182 3.144e-17 14 Genes in module_244 www.broad.mit.e...
Broad module_152 View Gene Set 1.04e-18 121 3.149e-17 15 Genes in module_152 www.broad.mit.e...
Broad module_183 View Gene Set 4.468e-18 52 1.268e-16 16 Genes in module_183 www.broad.mit.e...
Broad module_62 View Gene Set 7.646e-18 88 2.042e-16 17 Genes in module_62 www.broad.mit.e...
Broad module_126 View Gene Set 1.729e-17 173 4.36e-16 18 Genes in module_126 www.broad.mit.e...
Broad module_18 View Gene Set 1.77e-16 434 4.228e-15 19 Genes in module_18 www.broad.mit.e...
Broad module_159 View Gene Set 1.392e-14 81 3.159e-13 20 Genes in module_159 www.broad.mit.e...
Broad module_149 View Gene Set 4.708e-14 36 1.018e-12 21 Genes in module_149 www.broad.mit.e...
Broad module_57 View Gene Set 2.925e-13 54 6.037e-12 22 Genes in module_57 www.broad.mit.e...
Broad module_403 View Gene Set 1.464e-11 44 2.89e-10 23 Genes in module_403 www.broad.mit.e...
Broad module_115 View Gene Set 3.338e-11 27 6.314e-10 24 Genes in module_115 www.broad.mit.e...
Broad module_219 View Gene Set 4.727e-11 26 8.585e-10 25 Genes in module_219 www.broad.mit.e...
Broad module_278 View Gene Set 4.997e-11 34 8.725e-10 26 Genes in module_278 www.broad.mit.e...
Broad module_22 View Gene Set 8.058e-11 45 1.355e-09 27 Genes in module_22 www.broad.mit.e...
Broad module_245 View Gene Set 2.58e-10 26 4.183e-09 28 Genes in module_245 www.broad.mit.e...
Broad module_155 View Gene Set 5.099e-10 25 7.983e-09 29 Genes in module_155 www.broad.mit.e...
Broad module_61 View Gene Set 5.969e-10 50 9.033e-09 30 Genes in module_61 www.broad.mit.e...
Broad module_337 View Gene Set 8.324e-10 59 1.219e-08 31 Genes in module_337 www.broad.mit.e...
Broad module_299 View Gene Set 9.315e-10 33 1.321e-08 32 Genes in module_299 www.broad.mit.e...
Broad module_277 View Gene Set 1.383e-09 48 1.903e-08 33 Genes in module_277 www.broad.mit.e...
Broad module_81 View Gene Set 6.195e-09 20 8.272e-08 34 Genes in module_81 www.broad.mit.e...
Broad module_158 View Gene Set 1.578e-08 41 2.047e-07 35 Genes in module_158 www.broad.mit.e...
Broad module_72 View Gene Set 1.649e-08 293 2.079e-07 36 Genes in module_72 www.broad.mit.e...
Broad module_197 View Gene Set 1.949e-08 170 2.391e-07 37 Genes in module_197 www.broad.mit.e...
Broad module_125 View Gene Set 2.482e-08 42 2.965e-07 38 Genes in module_125 www.broad.mit.e...
Broad module_77 View Gene Set 2.85e-08 28 3.318e-07 39 Genes in module_77 www.broad.mit.e...
Broad module_91 View Gene Set 8.596e-08 37 9.757e-07 40 Genes in module_91 www.broad.mit.e...
Broad module_273 View Gene Set 1.008e-07 50 1.117e-06 41 Genes in module_273 www.broad.mit.e...
Broad module_331 View Gene Set 1.144e-07 65 1.237e-06 42 Genes in module_331 www.broad.mit.e...
Broad module_29 View Gene Set 1.216e-07 28 1.284e-06 43 Genes in module_29 www.broad.mit.e...
Broad module_102 View Gene Set 1.497e-07 18 1.545e-06 44 Genes in module_102 www.broad.mit.e...
Broad module_392 View Gene Set 1.778e-07 18 1.794e-06 45 Genes in module_392 www.broad.mit.e...
Broad module_105 View Gene Set 2.692e-07 192 2.656e-06 46 Genes in module_105 www.broad.mit.e...
Broad module_82 View Gene Set 3.118e-07 24 3.012e-06 47 Genes in module_82 www.broad.mit.e...
Broad module_352 View Gene Set 3.488e-07 17 3.299e-06 48 Genes in module_352 www.broad.mit.e...
Broad module_212 View Gene Set 4.317e-07 316 4e-06 49 Genes in module_212 www.broad.mit.e...
Broad module_388 View Gene Set 7.807e-07 17 7.089e-06 50 Genes in module_388 www.broad.mit.e...
Broad module_355 View Gene Set 1.094e-06 28 9.735e-06 51 Genes in module_355 www.broad.mit.e...
Broad module_42 View Gene Set 1.3e-06 25 1.135e-05 52 Genes in module_42 www.broad.mit.e...
Broad module_4 View Gene Set 1.395e-06 21 1.195e-05 53 Genes in module_4 www.broad.mit.e...
Broad module_451 View Gene Set 1.525e-06 29 1.282e-05 54 Genes in module_451 www.broad.mit.e...
Broad module_52 View Gene Set 1.918e-06 415 1.583e-05 55 Genes in module_52 www.broad.mit.e...
Broad module_308 View Gene Set 2.221e-06 66 1.801e-05 56 Genes in module_308 www.broad.mit.e...
Broad module_323 View Gene Set 2.691e-06 54 2.143e-05 57 Genes in module_323 www.broad.mit.e...
Broad module_16 View Gene Set 2.894e-06 495 2.265e-05 58 Genes in module_16 www.broad.mit.e...
Broad module_56 View Gene Set 3.86e-06 12 2.97e-05 59 Genes in module_56 www.broad.mit.e...
Broad module_93 View Gene Set 3.944e-06 180 2.984e-05 60 Genes in module_93 www.broad.mit.e...
Broad module_28 View Gene Set 4.252e-06 32 3.129e-05 61 Genes in module_28 www.broad.mit.e...
Broad module_233 View Gene Set 4.273e-06 22 3.129e-05 61 Genes in module_233 www.broad.mit.e...
Broad module_332 View Gene Set 4.387e-06 35 3.162e-05 63 Genes in module_332 www.broad.mit.e...
Broad module_177 View Gene Set 9.664e-06 101 6.856e-05 64 Genes in module_177 www.broad.mit.e...
Broad module_567 View Gene Set 1.27e-05 90 8.871e-05 65 Genes in module_567 www.broad.mit.e...
Broad module_87 View Gene Set 1.558e-05 44 0.0001072 66 Genes in module_87 www.broad.mit.e...
Broad module_21 View Gene Set 2.036e-05 10 0.0001379 67 Genes in module_21 www.broad.mit.e...
Broad module_150 View Gene Set 2.109e-05 15 0.0001408 68 Genes in module_150 www.broad.mit.e...
Broad module_303 View Gene Set 2.145e-05 27 0.0001411 69 Genes in module_303 www.broad.mit.e...
Broad module_133 View Gene Set 2.565e-05 15 0.0001664 70 Genes in module_133 www.broad.mit.e...
Broad module_25 View Gene Set 3.353e-05 13 0.0002144 71 Genes in module_25 www.broad.mit.e...
Broad module_243 View Gene Set 4.109e-05 73 0.0002591 72 Genes in module_243 www.broad.mit.e...
Broad module_315 View Gene Set 4.231e-05 15 0.0002632 73 Genes in module_315 www.broad.mit.e...
Broad module_86 View Gene Set 4.852e-05 43 0.0002977 74 Genes in module_86 www.broad.mit.e...
Broad module_429 View Gene Set 6.201e-05 14 0.0003754 75 Genes in module_429 www.broad.mit.e...
Broad module_15 View Gene Set 9.67e-05 347 0.0005777 76 Genes in module_15 www.broad.mit.e...
Broad module_36 View Gene Set 0.0001223 146 0.0007118 77 Genes in module_36 www.broad.mit.e...
Broad module_43 View Gene Set 0.0001223 97 0.0007118 77 Genes in module_43 www.broad.mit.e...
Broad module_168 View Gene Set 0.000137 22 0.0007875 79 Genes in module_168 www.broad.mit.e...
Broad module_320 View Gene Set 0.0001582 19 0.0008978 80 Genes in module_320 www.broad.mit.e...
Broad module_147 View Gene Set 0.0001683 102 0.0009392 81 Genes in module_147 www.broad.mit.e...
Broad module_222 View Gene Set 0.0001702 22 0.0009392 81 Genes in module_222 www.broad.mit.e...
Broad module_397 View Gene Set 0.0001717 114 0.0009392 81 Genes in module_397 www.broad.mit.e...
Broad module_127 View Gene Set 0.0001748 26 0.0009447 84 Genes in module_127 www.broad.mit.e...
Broad module_160 View Gene Set 0.0001874 15 0.0009891 85 Genes in module_160 www.broad.mit.e...
Broad module_363 View Gene Set 0.0001873 48 0.0009891 85 Genes in module_363 www.broad.mit.e...
Broad module_31 View Gene Set 0.0002033 7 0.001061 87 Genes in module_31 www.broad.mit.e...
Broad module_447 View Gene Set 0.000214 35 0.001104 88 Genes in module_447 www.broad.mit.e...
Broad module_221 View Gene Set 0.000287 30 0.001464 89 Genes in module_221 www.broad.mit.e...
Broad module_552 View Gene Set 0.000301 18 0.001518 90 Genes in module_552 www.broad.mit.e...
Broad module_281 View Gene Set 0.0003079 28 0.001536 91 Genes in module_281 www.broad.mit.e...
Broad module_35 View Gene Set 0.0003917 16 0.001933 92 Genes in module_35 www.broad.mit.e...
Broad module_189 View Gene Set 0.0004131 23 0.002017 93 Genes in module_189 www.broad.mit.e...
Broad module_184 View Gene Set 0.0004939 29 0.00236 94 Genes in module_184 www.broad.mit.e...
Broad module_325 View Gene Set 0.0004916 46 0.00236 94 Genes in module_325 www.broad.mit.e...
Broad module_485 View Gene Set 0.0005114 44 0.002418 96 Genes in module_485 www.broad.mit.e...
Broad module_226 View Gene Set 0.0005356 27 0.002507 97 Genes in module_226 www.broad.mit.e...
Broad module_307 View Gene Set 0.000594 24 0.002752 98 Genes in module_307 www.broad.mit.e...
Broad module_206 View Gene Set 0.0007596 139 0.003483 99 Genes in module_206 www.broad.mit.e...
Broad module_229 View Gene Set 0.0008297 31 0.003767 100 Genes in module_229 www.broad.mit.e...
Broad module_110 View Gene Set 0.0009917 15 0.004458 101 Genes in module_110 www.broad.mit.e...
Broad module_350 View Gene Set 0.001003 57 0.004464 102 Genes in module_350 www.broad.mit.e...
Broad module_503 View Gene Set 0.001043 106 0.004596 103 Genes in module_503 www.broad.mit.e...
Broad module_116 View Gene Set 0.001168 29 0.005099 104 Genes in module_116 www.broad.mit.e...
Broad module_432 View Gene Set 0.001204 15 0.005204 105 Genes in module_432 www.broad.mit.e...
Broad module_257 View Gene Set 0.001215 137 0.005204 106 Genes in module_257 www.broad.mit.e...
Broad module_318 View Gene Set 0.00152 28 0.00645 107 Genes in module_318 www.broad.mit.e...
Broad module_312 View Gene Set 0.001603 45 0.006683 108 Genes in module_312 www.broad.mit.e...
Broad module_568 View Gene Set 0.001604 70 0.006683 108 Genes in module_568 www.broad.mit.e...
Broad module_457 View Gene Set 0.001644 9 0.006787 110 Genes in module_457 www.broad.mit.e...
Broad module_576 View Gene Set 0.001694 104 0.006927 111 Genes in module_576 www.broad.mit.e...
Broad module_50 View Gene Set 0.001833 13 0.00743 112 Genes in module_50 www.broad.mit.e...
Broad module_349 View Gene Set 0.002152 17 0.008647 113 Genes in module_349 www.broad.mit.e...
Broad module_538 View Gene Set 0.00222 8 0.00884 114 Genes in module_538 www.broad.mit.e...
Broad module_450 View Gene Set 0.002468 9 0.009743 115 Genes in module_450 www.broad.mit.e...
Broad module_195 View Gene Set 0.00252 138 0.009863 116 Genes in module_195 www.broad.mit.e...
Broad module_254 View Gene Set 0.002956 58 0.01147 117 Genes in module_254 www.broad.mit.e...
Broad module_414 View Gene Set 0.003024 17 0.01164 118 Genes in module_414 www.broad.mit.e...
Broad module_491 View Gene Set 0.003483 74 0.01329 119 Genes in module_491 www.broad.mit.e...
Broad module_356 View Gene Set 0.004002 141 0.01514 120 Genes in module_356 www.broad.mit.e...
Broad module_97 View Gene Set 0.004805 91 0.01803 121 Genes in module_97 www.broad.mit.e...
Broad module_90 View Gene Set 0.006167 17 0.02295 122 Genes in module_90 www.broad.mit.e...
Broad module_376 View Gene Set 0.006484 7 0.02393 123 Genes in module_376 www.broad.mit.e...
Broad module_182 View Gene Set 0.007515 94 0.02729 124 Genes in module_182 www.broad.mit.e...
Broad module_305 View Gene Set 0.007488 19 0.02729 124 Genes in module_305 www.broad.mit.e...
Broad module_286 View Gene Set 0.008499 37 0.03062 126 Genes in module_286 www.broad.mit.e...
Broad module_180 View Gene Set 0.01056 113 0.03776 127 Genes in module_180 www.broad.mit.e...
Broad module_519 View Gene Set 0.01153 15 0.0409 128 Genes in module_519 www.broad.mit.e...
Broad module_103 View Gene Set 0.01331 12 0.04683 129 Genes in module_103 www.broad.mit.e...
Broad module_40 View Gene Set 0.01388 81 0.04846 130 Genes in module_40 www.broad.mit.e...

Gene Set Collection: Broad.c5.BP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 1.838e-34 1197 1.516e-31 1 Genes annotated by the GO term GO:0006139. The chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad BIOPOLYMER_METABOLIC_PROCESS View Gene Set 2.2e-33 1623 9.074e-31 2 Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers long repeating chains of monomers found in nature e.g. polysaccharides and proteins. www.broad.mit.e...
Broad RNA_METABOLIC_PROCESS View Gene Set 1.226e-25 801 3.371e-23 3 Genes annotated by the GO term GO:0016070. The chemical reactions and pathways involving RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. www.broad.mit.e...
Broad RNA_PROCESSING View Gene Set 1.26e-23 147 2.6e-21 4 Genes annotated by the GO term GO:0006396. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. www.broad.mit.e...
Broad CELLULAR_PROTEIN_METABOLIC_PROCESS View Gene Set 5.776e-18 1085 9.531e-16 5 Genes annotated by the GO term GO:0044267. The chemical reactions and pathways involving a specific protein rather than of proteins in general occurring at the level of an individual cell. Includes protein modification. www.broad.mit.e...
Broad CELLULAR_MACROMOLECULE_METABOLIC_PROCESS View Gene Set 1.41e-17 1099 1.939e-15 6 Genes annotated by the GO term GO:0044260. The chemical reactions and pathways involving macromolecules large molecules including proteins nucleic acids and carbohydrates as carried out by individual cells. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS_AND_ASSEMBLY View Gene Set 4.578e-17 74 5.235e-15 7 Genes annotated by the GO term GO:0022613. The cellular process by which a complex containing RNA and proteins is synthesized aggregates and bonds together. www.broad.mit.e...
Broad PROTEIN_METABOLIC_PROCESS View Gene Set 5.076e-17 1198 5.235e-15 7 Genes annotated by the GO term GO:0019538. The chemical reactions and pathways involving a specific protein rather than of proteins in general. Includes protein modification. www.broad.mit.e...
Broad CELLULAR_BIOSYNTHETIC_PROCESS View Gene Set 1.2e-16 311 1.1e-14 9 Genes annotated by the GO term GO:0044249. The chemical reactions and pathways resulting in the formation of substances carried out by individual cells. www.broad.mit.e...
Broad BIOSYNTHETIC_PROCESS View Gene Set 1.914e-16 459 1.579e-14 10 Genes annotated by the GO term GO:0009058. The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones as in growth and other biosynthetic processes. www.broad.mit.e...
Broad CELL_CYCLE_GO_0007049 View Gene Set 8.677e-15 304 6.508e-13 11 Genes annotated by the GO term GO:0007049. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. www.broad.mit.e...
Broad RNA_SPLICING View Gene Set 9.984e-15 73 6.864e-13 12 Genes annotated by the GO term GO:0008380. The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. www.broad.mit.e...
Broad TRANSLATION View Gene Set 3.782e-14 177 2.4e-12 13 Genes annotated by the GO term GO:0006412. The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. www.broad.mit.e...
Broad PROTEIN_RNA_COMPLEX_ASSEMBLY View Gene Set 6.743e-14 59 3.973e-12 14 Genes annotated by the GO term GO:0022618. The aggregation arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. www.broad.mit.e...
Broad MRNA_METABOLIC_PROCESS View Gene Set 3.264e-13 70 1.795e-11 15 Genes annotated by the GO term GO:0016071. The chemical reactions and pathways involving mRNA messenger RNA which is responsible for carrying the coded genetic 'message' transcribed from DNA to sites of protein assembly at the ribosomes. www.broad.mit.e...
Broad CELL_CYCLE_PROCESS View Gene Set 4.113e-13 187 2.121e-11 16 Genes annotated by the GO term GO:0022402. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad MACROMOLECULE_BIOSYNTHETIC_PROCESS View Gene Set 4.498e-13 313 2.183e-11 17 Genes annotated by the GO term GO:0009059. The chemical reactions and pathways resulting in the formation of macromolecules large molecules including proteins nucleic acids and carbohydrates. www.broad.mit.e...
Broad MRNA_PROCESSING_GO_0006397 View Gene Set 2.411e-12 59 1.105e-10 18 Genes annotated by the GO term GO:0006397. Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. www.broad.mit.e...
Broad PROTEIN_FOLDING View Gene Set 3.34e-12 56 1.45e-10 19 Genes annotated by the GO term GO:0006457. The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX_ASSEMBLY View Gene Set 4.801e-12 271 1.931e-10 20 Genes annotated by the GO term GO:0065003. The aggregation arrangement and bonding together of a set of macromolecules to form a complex. www.broad.mit.e...
Broad INTRACELLULAR_TRANSPORT View Gene Set 4.915e-12 271 1.931e-10 20 Genes annotated by the GO term GO:0046907. The directed movement of substances within a cell. www.broad.mit.e...
Broad DNA_METABOLIC_PROCESS View Gene Set 6.233e-12 253 2.337e-10 22 Genes annotated by the GO term GO:0006259. The chemical reactions and pathways involving DNA deoxyribonucleic acid one of the two main types of nucleic acid consisting of a long unbranched macromolecule formed from one or more commonly two strands of linked deoxyribonucleotides. www.broad.mit.e...
Broad ORGANELLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 1.146e-11 458 4.112e-10 23 Genes annotated by the GO term GO:0006996. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of any organelle within a cell. www.broad.mit.e...
Broad CELLULAR_COMPONENT_ASSEMBLY View Gene Set 2.814e-11 288 9.672e-10 24 Genes annotated by the GO term GO:0022607. A cellular process that results in the assembly of a part of the cell. www.broad.mit.e...
Broad MITOTIC_CELL_CYCLE View Gene Set 3.256e-11 148 1.074e-09 25 Genes annotated by the GO term GO:0000278. Progression through the phases of the mitotic cell cycle the most common eukaryotic cell cycle which canonically comprises four successive phases called G1 S G2 and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division or G1 and G2 phases may be absent. www.broad.mit.e...
Broad TRANSCRIPTION_DNA_DEPENDENT View Gene Set 1.567e-10 623 4.972e-09 26 Genes annotated by the GO term GO:0006351. The synthesis of RNA on a template of DNA. www.broad.mit.e...
Broad RNA_BIOSYNTHETIC_PROCESS View Gene Set 1.83e-10 625 5.392e-09 27 Genes annotated by the GO term GO:0032774. The chemical reactions and pathways resulting in the formation of RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. www.broad.mit.e...
Broad CELL_CYCLE_PHASE View Gene Set 1.794e-10 167 5.392e-09 27 Genes annotated by the GO term GO:0022403. A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad ESTABLISHMENT_OF_CELLULAR_LOCALIZATION View Gene Set 4.005e-10 342 1.139e-08 29 Genes annotated by the GO term GO:0051649. The directed movement of a substance or cellular entity such as a protein complex or organelle to a specific location within or in the membrane of a cell. www.broad.mit.e...
Broad TRANSCRIPTION View Gene Set 8.231e-10 738 2.263e-08 30 Genes annotated by the GO term GO:0006350. The synthesis of either RNA on a template of DNA or DNA on a template of RNA. www.broad.mit.e...
Broad TRANSLATIONAL_INITIATION View Gene Set 2.325e-09 39 6.187e-08 31 Genes annotated by the GO term GO:0006413. The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome mRNA and an initiation complex that contains the first aminoacyl-tRNA. www.broad.mit.e...
Broad CELLULAR_LOCALIZATION View Gene Set 2.794e-09 360 6.984e-08 32 Genes annotated by the GO term GO:0051641. The processes by which a substance or cellular entity such as a protein complex or organelle is transported to and/or maintained in a specific location within or in the membrane of a cell. www.broad.mit.e...
Broad M_PHASE_OF_MITOTIC_CELL_CYCLE View Gene Set 2.737e-09 83 6.984e-08 32 Genes annotated by the GO term GO:0000087. Progression through M phase the part of the mitotic cell cycle during which mitosis takes place. www.broad.mit.e...
Broad DNA_REPLICATION View Gene Set 2.924e-09 101 7.095e-08 34 Genes annotated by the GO term GO:0006260. The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. www.broad.mit.e...
Broad CHROMOSOME_ORGANIZATION_AND_BIOGENESIS View Gene Set 4.186e-09 117 9.868e-08 35 Genes annotated by the GO term GO:0051276. A process that is carried out at the cellular level that results in the formation arrangement of constituent parts or disassembly of chromosomes structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. www.broad.mit.e...
Broad INTRACELLULAR_PROTEIN_TRANSPORT View Gene Set 9.959e-09 138 2.282e-07 36 Genes annotated by the GO term GO:0006886. The directed movement of proteins in a cell including the movement of proteins between specific compartments or structures within a cell such as organelles of a eukaryotic cell. www.broad.mit.e...
Broad MITOSIS View Gene Set 1.204e-08 81 2.685e-07 37 Genes annotated by the GO term GO:0007067. Progression through mitosis the division of the eukaryotic cell nucleus to produce two daughter nuclei that usually contain the identical chromosome complement to their mother. www.broad.mit.e...
Broad M_PHASE View Gene Set 1.605e-08 111 3.485e-07 38 Genes annotated by the GO term GO:0000279. Progression through M phase the part of the cell cycle comprising nuclear division. www.broad.mit.e...
Broad PROTEIN_TRANSPORT View Gene Set 4.586e-08 150 9.701e-07 39 Genes annotated by the GO term GO:0015031. The directed movement of proteins into out of within or between cells. www.broad.mit.e...
Broad BIOPOLYMER_CATABOLIC_PROCESS View Gene Set 1.436e-07 115 2.89e-06 40 Genes annotated by the GO term GO:0043285. The chemical reactions and pathways resulting in the breakdown of biopolymers long repeating chains of monomers found in nature e.g. polysaccharides and proteins. www.broad.mit.e...
Broad MACROMOLECULE_LOCALIZATION View Gene Set 1.432e-07 228 2.89e-06 40 Genes annotated by the GO term GO:0033036. The processes by which a macromolecule is transported to or maintained in a specific location. www.broad.mit.e...
Broad TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 2.567e-07 449 5.042e-06 42 Genes annotated by the GO term GO:0006366. The synthesis of RNA from a DNA template by RNA polymerase II (Pol II) originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). www.broad.mit.e...
Broad REGULATION_OF_TRANSLATIONAL_INITIATION View Gene Set 4.296e-07 31 8.242e-06 43 Genes annotated by the GO term GO:0006446. Any process that modulates the frequency rate or extent of translational initiation. www.broad.mit.e...
Broad REGULATION_OF_CELLULAR_METABOLIC_PROCESS View Gene Set 4.575e-07 767 8.578e-06 44 Genes annotated by the GO term GO:0031323. Any process that modulates the frequency rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. www.broad.mit.e...
Broad REGULATION_OF_METABOLIC_PROCESS View Gene Set 5.451e-07 779 9.994e-06 45 Genes annotated by the GO term GO:0019222. Any process that modulates the frequency rate or extent of the chemical reactions and pathways within a cell or an organism. www.broad.mit.e...
Broad CELLULAR_PROTEIN_CATABOLIC_PROCESS View Gene Set 9.963e-07 58 1.749e-05 46 Genes annotated by the GO term GO:0044257. The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. www.broad.mit.e...
Broad CELLULAR_CATABOLIC_PROCESS View Gene Set 9.83e-07 209 1.749e-05 46 Genes annotated by the GO term GO:0044248. The chemical reactions and pathways resulting in the breakdown of substances carried out by individual cells. www.broad.mit.e...
Broad CATABOLIC_PROCESS View Gene Set 1.141e-06 221 1.962e-05 48 Genes annotated by the GO term GO:0009056. The chemical reactions and pathways resulting in the breakdown of substances including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. www.broad.mit.e...
Broad REGULATION_OF_NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 1.941e-06 601 3.267e-05 49 Genes annotated by the GO term GO:0019219. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad RIBOSOME_BIOGENESIS_AND_ASSEMBLY View Gene Set 2.561e-06 14 4.225e-05 50 Genes annotated by the GO term GO:0042254. The process of the formation of the constituents of the ribosome subunits their assembly and their transport to the sites of protein synthesis. www.broad.mit.e...
Broad REGULATION_OF_GENE_EXPRESSION View Gene Set 2.872e-06 660 4.646e-05 51 Genes annotated by the GO term GO:0010468. Any process that modulates the frequency rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. www.broad.mit.e...
Broad PROTEIN_CATABOLIC_PROCESS View Gene Set 3.114e-06 68 4.941e-05 52 Genes annotated by the GO term GO:0030163. The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native active configuration with or without the hydrolysis of peptide bonds. www.broad.mit.e...
Broad MACROMOLECULE_CATABOLIC_PROCESS View Gene Set 3.357e-06 135 5.129e-05 53 Genes annotated by the GO term GO:0009057. The chemical reactions and pathways resulting in the breakdown of a macromolecule any large molecule including proteins nucleic acids and carbohydrates. www.broad.mit.e...
Broad RNA_SPLICINGVIA_TRANSESTERIFICATION_REACTIONS View Gene Set 3.345e-06 27 5.129e-05 53 Genes annotated by the GO term GO:0000375. Splicing of RNA via a series of two transesterification reactions. www.broad.mit.e...
Broad CELLULAR_MACROMOLECULE_CATABOLIC_PROCESS View Gene Set 3.561e-06 103 5.341e-05 55 Genes annotated by the GO term GO:0044265. The chemical reactions and pathways resulting in the breakdown of a macromolecule any large molecule including proteins nucleic acids and carbohydrates as carried out by individual cells. www.broad.mit.e...
Broad CHROMOSOME_SEGREGATION View Gene Set 3.701e-06 31 5.357e-05 56 Genes annotated by the GO term GO:0007059. The process by which genetic material in the form of chromosomes is organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad PROTEIN_LOCALIZATION View Gene Set 3.681e-06 207 5.357e-05 56 Genes annotated by the GO term GO:0008104. The processes by which a protein is transported to or maintained in a specific location. www.broad.mit.e...
Broad RESPONSE_TO_DNA_DAMAGE_STIMULUS View Gene Set 3.971e-06 159 5.576e-05 58 Genes annotated by the GO term GO:0006974. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. www.broad.mit.e...
Broad REGULATION_OF_CELL_CYCLE View Gene Set 3.988e-06 176 5.576e-05 58 Genes annotated by the GO term GO:0051726. Any process that modulates the rate or extent of progression through the cell cycle. www.broad.mit.e...
Broad RESPONSE_TO_ENDOGENOUS_STIMULUS View Gene Set 7.592e-06 197 0.0001044 60 Genes annotated by the GO term GO:0009719. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of an endogenous stimulus. www.broad.mit.e...
Broad ESTABLISHMENT_OF_PROTEIN_LOCALIZATION View Gene Set 8.152e-06 183 0.0001103 61 Genes annotated by the GO term GO:0045184. The directed movement of a protein to a specific location. www.broad.mit.e...
Broad ESTABLISHMENT_AND_OR_MAINTENANCE_OF_CHROMATIN_ARCHITECTURE View Gene Set 9.343e-06 72 0.0001243 62 Genes annotated by the GO term GO:0006325. The specification formation and maintenance of the physical structure of eukaryotic chromatin. www.broad.mit.e...
Broad GOLGI_VESICLE_TRANSPORT View Gene Set 1.046e-05 47 0.000137 63 Genes annotated by the GO term GO:0048193. The directed movement of substances into out of or within the Golgi apparatus mediated by vesicles. www.broad.mit.e...
Broad PROTEIN_TARGETING View Gene Set 1.19e-05 103 0.0001534 64 Genes annotated by the GO term GO:0006605. The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif. www.broad.mit.e...
Broad REGULATION_OF_RNA_METABOLIC_PROCESS View Gene Set 1.573e-05 457 0.0001996 65 Genes annotated by the GO term GO:0051252. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving RNA. www.broad.mit.e...
Broad ORGANIC_ACID_METABOLIC_PROCESS View Gene Set 1.968e-05 175 0.000246 66 Genes annotated by the GO term GO:0006082. The chemical reactions and pathways involving organic acids any acidic compound containing carbon in covalent linkage. www.broad.mit.e...
Broad DNA_DEPENDENT_DNA_REPLICATION View Gene Set 2.033e-05 55 0.0002504 67 Genes annotated by the GO term GO:0006261. The process whereby new strands of DNA are synthesized using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. www.broad.mit.e...
Broad MITOCHONDRION_ORGANIZATION_AND_BIOGENESIS View Gene Set 2.824e-05 47 0.0003426 68 Genes annotated by the GO term GO:0007005. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of a mitochondrion; includes mitochondrial morphology and distribution and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. www.broad.mit.e...
Broad ESTABLISHMENT_OF_ORGANELLE_LOCALIZATION View Gene Set 2.953e-05 17 0.0003531 69 Genes annotated by the GO term GO:0051656. The directed movement of an organelle to a specific location. www.broad.mit.e...
Broad PROTEIN_TARGETING_TO_MITOCHONDRION View Gene Set 3.237e-05 10 0.0003815 70 Genes annotated by the GO term GO:0006626. The process of directing proteins towards and into the mitochondrion mediated by mitochondrial proteins that recognize signals contained within the imported protein. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTIONDNA_DEPENDENT View Gene Set 3.538e-05 452 0.0004112 71 Genes annotated by the GO term GO:0006355. Any process that modulates the frequency rate or extent of DNA-dependent transcription. www.broad.mit.e...
Broad DNA_REPAIR View Gene Set 3.938e-05 123 0.0004478 72 Genes annotated by the GO term GO:0006281. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations chemical mutagens fungal and bacterial toxins etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal base excision repair nucleotide excision repair photoreactivation bypass double-strand break repair pathway and mismatch repair pathway. www.broad.mit.e...
Broad CARBOXYLIC_ACID_METABOLIC_PROCESS View Gene Set 3.963e-05 173 0.0004478 72 Genes annotated by the GO term GO:0019752. The chemical reactions and pathways involving carboxylic acids any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). www.broad.mit.e...
Broad RRNA_PROCESSING View Gene Set 4.991e-05 11 0.0005565 74 Genes annotated by the GO term GO:0006364. Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. www.broad.mit.e...
Broad BIOPOLYMER_MODIFICATION View Gene Set 5.256e-05 627 0.0005782 75 Genes annotated by the GO term GO:0043412. The covalent alteration of one or more monomeric units in a polypeptide polynucleotide polysaccharide or other biological polymer resulting in a change in its properties. www.broad.mit.e...
Broad INTERPHASE View Gene Set 5.528e-05 68 0.0006001 76 Genes annotated by the GO term GO:0051325. Progression through interphase the stage of cell cycle between successive rounds of chromosome segregation. Canonically interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTION View Gene Set 6.051e-05 555 0.0006483 77 Genes annotated by the GO term GO:0045449. Any process that modulates the frequency rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. www.broad.mit.e...
Broad CELL_CYCLE_CHECKPOINT_GO_0000075 View Gene Set 8.422e-05 47 0.0008908 78 Genes annotated by the GO term GO:0000075. A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. www.broad.mit.e...
Broad INTERPHASE_OF_MITOTIC_CELL_CYCLE View Gene Set 8.749e-05 62 0.0009136 79 Genes annotated by the GO term GO:0051329. Progression through interphase the stage of cell cycle between successive rounds of mitosis. Canonically interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. www.broad.mit.e...
Broad COFACTOR_METABOLIC_PROCESS View Gene Set 9.06e-05 53 0.0009343 80 Genes annotated by the GO term GO:0051186. The chemical reactions and pathways involving a cofactor a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic such as the metal atoms zinc iron and copper in certain forms or organic in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. www.broad.mit.e...
Broad COENZYME_METABOLIC_PROCESS View Gene Set 9.773e-05 37 0.0009954 81 Genes annotated by the GO term GO:0006732. The chemical reactions and pathways involving coenzymes any of various nonprotein organic cofactors that are required in addition to an enzyme and a substrate for an enzymatic reaction to proceed. www.broad.mit.e...
Broad VESICLE_MEDIATED_TRANSPORT View Gene Set 0.0001172 188 0.001165 82 Genes annotated by the GO term GO:0016192. The directed movement of substances either within a vesicle or in the vesicle membrane into out of or within a cell. www.broad.mit.e...
Broad PROTEIN_MODIFICATION_PROCESS View Gene Set 0.0001161 610 0.001165 82 Genes annotated by the GO term GO:0006464. The covalent alteration of one or more amino acids occurring in proteins peptides and nascent polypeptides (co-translational post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). www.broad.mit.e...
Broad AMINO_ACID_METABOLIC_PROCESS View Gene Set 0.0001194 75 0.001173 84 Genes annotated by the GO term GO:0006520. The chemical reactions and pathways involving amino acids organic acids containing one or more amino substituents. www.broad.mit.e...
Broad CHROMOSOME_CONDENSATION View Gene Set 0.0001288 10 0.001251 85 Genes annotated by the GO term GO:0030261. The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division or during apoptosis in eukaryotic cells. www.broad.mit.e...
Broad CHROMATIN_ASSEMBLY_OR_DISASSEMBLY View Gene Set 0.0001791 26 0.001719 86 Genes annotated by the GO term GO:0006333. The formation or destruction of chromatin structures. www.broad.mit.e...
Broad CHROMATIN_MODIFICATION View Gene Set 0.0001926 50 0.001826 87 Genes annotated by the GO term GO:0016568. The alteration of DNA or protein in chromatin which may result in changing the chromatin structure. www.broad.mit.e...
Broad TRNA_METABOLIC_PROCESS View Gene Set 0.0002469 18 0.002315 88 Genes annotated by the GO term GO:0006399. The chemical reactions and pathways involving tRNA transfer RNA a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases the function of which has not been completely established. www.broad.mit.e...
Broad NUCLEAR_TRANSPORT View Gene Set 0.0002545 84 0.002359 89 Genes annotated by the GO term GO:0051169. The directed movement of substances into out of or within the nucleus. www.broad.mit.e...
Broad DOUBLE_STRAND_BREAK_REPAIR View Gene Set 0.000314 22 0.002878 90 Genes annotated by the GO term GO:0006302. The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. www.broad.mit.e...
Broad RRNA_METABOLIC_PROCESS View Gene Set 0.0003599 12 0.003263 91 Genes annotated by the GO term GO:0016072. The chemical reactions and pathways involving rRNA ribosomal RNA a structural constituent of ribosomes. www.broad.mit.e...
Broad ORGANELLE_LOCALIZATION View Gene Set 0.0003717 24 0.003333 92 Genes annotated by the GO term GO:0051640. The processes by which an organelle is transported to and/or maintained in a specific location. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 0.00039 205 0.00346 93 Genes annotated by the GO term GO:0045934. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad SISTER_CHROMATID_SEGREGATION View Gene Set 0.0003982 17 0.003495 94 Genes annotated by the GO term GO:0000819. The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad ANTI_APOPTOSIS View Gene Set 0.0004308 115 0.00373 95 Genes annotated by the GO term GO:0006916. A process which directly inhibits any of the steps required for cell death by apoptosis. www.broad.mit.e...
Broad NUCLEOCYTOPLASMIC_TRANSPORT View Gene Set 0.000434 83 0.00373 95 Genes annotated by the GO term GO:0006913. The directed movement of molecules between the nucleus and the cytoplasm. www.broad.mit.e...
Broad MITOTIC_SISTER_CHROMATID_SEGREGATION View Gene Set 0.0004475 16 0.003806 97 Genes annotated by the GO term GO:0000070. The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome composed of two sister chromatids aligns at the cell equator paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. www.broad.mit.e...
Broad UBIQUITIN_CYCLE View Gene Set 0.0004694 48 0.003952 98 Genes annotated by the GO term GO:0006512. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_TRANSPORT View Gene Set 0.0004746 31 0.003955 99 Genes annotated by the GO term GO:0015931. The directed movement of nucleobases nucleosides nucleotides and nucleic acids into out of within or between cells. www.broad.mit.e...
Broad NUCLEAR_EXPORT View Gene Set 0.0004919 31 0.004058 100 Genes annotated by the GO term GO:0051168. The directed movement of substances out of the nucleus. www.broad.mit.e...
Broad REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.0005306 124 0.004334 101 Genes annotated by the GO term GO:0051128. Any process that modulates the frequency rate or extent of the processes involved in the formation arrangement of constituent parts or disassembly of cell structures including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. www.broad.mit.e...
Broad REGULATION_OF_MITOSIS View Gene Set 0.0005449 40 0.004392 102 Genes annotated by the GO term GO:0007088. Any process that modulates the frequency rate or extent of mitosis. www.broad.mit.e...
Broad TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 0.0005484 29 0.004392 102 Genes annotated by the GO term GO:0006367. Processes involved in starting transcription from the RNA polymerase II promoter. www.broad.mit.e...
Broad MITOCHONDRIAL_TRANSPORT View Gene Set 0.0005863 20 0.004651 104 Genes annotated by the GO term GO:0006839. Transport of substances into out of or within a mitochondrion. www.broad.mit.e...
Broad SPLICEOSOME_ASSEMBLY View Gene Set 0.0006233 13 0.004897 105 Genes annotated by the GO term GO:0000245. The aggregation arrangement and bonding together of the spliceosome a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 0.0006496 285 0.005055 106 Genes annotated by the GO term GO:0006357. Any process that modulates the frequency rate or extent of transcription from an RNA polymerase II promoter. www.broad.mit.e...
Broad ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT View Gene Set 0.0007262 17 0.005599 107 Genes annotated by the GO term GO:0006888. The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. www.broad.mit.e...
Broad ONE_CARBON_COMPOUND_METABOLIC_PROCESS View Gene Set 0.0008228 26 0.006285 108 Genes annotated by the GO term GO:0006730. The chemical reactions and pathways involving compounds containing a single carbon atom. www.broad.mit.e...
Broad PROTEIN_EXPORT_FROM_NUCLEUS View Gene Set 0.0008964 10 0.006785 109 Genes annotated by the GO term GO:0006611. The directed movement of a protein from the nucleus into the cytoplasm. www.broad.mit.e...
Broad REGULATION_OF_DNA_METABOLIC_PROCESS View Gene Set 0.0009272 44 0.006923 110 Genes annotated by the GO term GO:0051052. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving DNA. www.broad.mit.e...
Broad SPINDLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.0009315 10 0.006923 110 Genes annotated by the GO term GO:0007051. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of the spindle the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. www.broad.mit.e...
Broad PROTEIN_DNA_COMPLEX_ASSEMBLY View Gene Set 0.001048 48 0.007648 112 Genes annotated by the GO term GO:0065004. The aggregation arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. www.broad.mit.e...
Broad AMINO_ACID_AND_DERIVATIVE_METABOLIC_PROCESS View Gene Set 0.001046 98 0.007648 112 Genes annotated by the GO term GO:0006519. The chemical reactions and pathways involving amino acids organic acids containing one or more amino substituents and compounds derived from amino acids. www.broad.mit.e...
Broad TRANSCRIPTION_INITIATION View Gene Set 0.001089 35 0.007884 114 Genes annotated by the GO term GO:0006352. Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter. www.broad.mit.e...
Broad PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION View Gene Set 0.001379 43 0.00989 115 Genes annotated by the GO term GO:0032446. A process by which one or more moieties of a small protein such as ubiquitin or a ubiquitin-like protein are covalently attached to a target protein. www.broad.mit.e...
Broad NUCLEOTIDE_SUGAR_METABOLIC_PROCESS View Gene Set 0.001405 9 0.009994 116 Genes annotated by the GO term GO:0009225. The chemical reactions and pathways involving nucleotide-sugars any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_APOPTOSIS View Gene Set 0.001421 147 0.01002 117 Genes annotated by the GO term GO:0043066. Any process that stops prevents or reduces the frequency rate or extent of cell death by apoptosis. www.broad.mit.e...
Broad PROTEIN_COMPLEX_ASSEMBLY View Gene Set 0.001453 167 0.01016 118 Genes annotated by the GO term GO:0006461. The aggregation arrangement and bonding together of a set of components to form a protein complex. www.broad.mit.e...
Broad BASE_EXCISION_REPAIR View Gene Set 0.001478 16 0.01025 119 Genes annotated by the GO term GO:0006284. In base excision repair an altered base is removed by a DNA glycosylase enzyme followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. www.broad.mit.e...
Broad REGULATION_OF_APOPTOSIS View Gene Set 0.001558 335 0.01071 120 Genes annotated by the GO term GO:0042981. Any process that modulates the occurrence or rate of cell death by apoptosis. www.broad.mit.e...
Broad TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER View Gene Set 0.00158 19 0.01077 121 Genes annotated by the GO term GO:0006383. The synthesis of RNA from a DNA template by RNA polymerase III (Pol III) originating at a Pol III-specific promoter. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_TRANSCRIPTION View Gene Set 0.00167 185 0.01129 122 Genes annotated by the GO term GO:0016481. Any process that stops prevents or reduces the frequency rate or extent of transcription. www.broad.mit.e...
Broad POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE View Gene Set 0.001685 80 0.0113 123 Genes annotated by the GO term GO:0043123. Any process that activates or increases the frequency rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_CELLULAR_PROCESS View Gene Set 0.001762 629 0.01172 124 Genes annotated by the GO term GO:0048523. Any process that stops prevents or reduces the frequency rate or extent of cellular processes those that are carried out at the cellular level but are not necessarily restricted to a single cell. For example cell communication occurs among more than one cell but occurs at the cellular level. www.broad.mit.e...
Broad PROTEIN_UBIQUITINATION View Gene Set 0.00188 40 0.01241 125 Genes annotated by the GO term GO:0016567. The process by which one or more ubiquitin moieties are added to a protein. www.broad.mit.e...
Broad REGULATION_OF_PROGRAMMED_CELL_DEATH View Gene Set 0.001948 336 0.01275 126 Genes annotated by the GO term GO:0043067. Any process that modulates the frequency rate or extent of programmed cell death cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad REGULATION_OF_GENE_EXPRESSION_EPIGENETIC View Gene Set 0.001981 30 0.01286 127 Genes annotated by the GO term GO:0040029. Any process that modulates the frequency rate or extent of gene expression; the process is mitotically or meiotically heritable or is stably self-propagated in the cytoplasm of a resting cell and does not entail a change in DNA sequence. www.broad.mit.e...
Broad MITOTIC_SPINDLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.001995 9 0.01286 127 Genes annotated by the GO term GO:0007052. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of the microtubule spindle during a mitotic cell cycle. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH View Gene Set 0.00201 148 0.01286 127 Genes annotated by the GO term GO:0043069. Any process that stops prevents or reduces the frequency rate or extent of programmed cell death cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDE_AND_NUCLEOTIDE_METABOLIC_PROCESS View Gene Set 0.002055 50 0.013 130 Genes annotated by the GO term GO:0055086. The chemical reactions and pathways involving nucleobases nucleosides and nucleotides. www.broad.mit.e...
Broad SECONDARY_METABOLIC_PROCESS View Gene Set 0.002065 25 0.013 130 Genes annotated by the GO term GO:0019748. The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types and may be useful for the organism as a whole. In unicellular organisms secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. www.broad.mit.e...
Broad DNA_RECOMBINATION View Gene Set 0.00222 47 0.01387 132 Genes annotated by the GO term GO:0006310. The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment intrachromosomal recombination or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation conjugation transduction or F-duction. www.broad.mit.e...
Broad CELLULAR_PROTEIN_COMPLEX_ASSEMBLY View Gene Set 0.002375 33 0.01462 133 Genes annotated by the GO term GO:0043623. The aggregation arrangement and bonding together of a set of components to form a protein complex occurring at the level of an individual cell. www.broad.mit.e...
Broad LIPID_BIOSYNTHETIC_PROCESS View Gene Set 0.002371 97 0.01462 133 Genes annotated by the GO term GO:0008610. The chemical reactions and pathways resulting in the formation of lipids compounds soluble in an organic solvent but not or sparingly in an aqueous solvent. www.broad.mit.e...
Broad APOPTOSIS_GO View Gene Set 0.002573 423 0.01573 135 Genes annotated by the GO term GO:0006915. A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. www.broad.mit.e...
Broad RNA_3END_PROCESSING View Gene Set 0.002712 10 0.01645 136 Genes annotated by the GO term GO:0031123. Any process involved in forming the mature 3' end of an RNA molecule. www.broad.mit.e...
Broad SECRETORY_PATHWAY View Gene Set 0.002741 82 0.01651 137 Genes annotated by the GO term GO:0045045. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER) completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER Golgi and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane. www.broad.mit.e...
Broad CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY View Gene Set 0.002776 13 0.01659 138 Genes annotated by the GO term GO:0043624. The disaggregation of a protein complex into its constituent components occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad PROGRAMMED_CELL_DEATH View Gene Set 0.003106 424 0.01844 139 Genes annotated by the GO term GO:0012501. Cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad CYTOKINESIS View Gene Set 0.003266 19 0.01911 140 Genes annotated by the GO term GO:0000910. A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth replication and segregation of cellular components. www.broad.mit.e...
Broad DNA_INTEGRITY_CHECKPOINT View Gene Set 0.00326 23 0.01911 140 Genes annotated by the GO term GO:0031570. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. www.broad.mit.e...
Broad REGULATION_OF_CHROMOSOME_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.003411 10 0.01956 142 Genes annotated by the GO term GO:0033044. Any process that modulates the frequency rate or extent of the processes involved in the formation arrangement of constituent parts or disassembly of a chromosome. www.broad.mit.e...
Broad PROTEIN_COMPLEX_DISASSEMBLY View Gene Set 0.003414 14 0.01956 142 Genes annotated by the GO term GO:0043241. The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX_DISASSEMBLY View Gene Set 0.003414 15 0.01956 142 Genes annotated by the GO term GO:0032984. The disaggregation of a macromolecular complex into its constituent components. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_TRANSCRIPTION_DNA_DEPENDENT View Gene Set 0.003558 127 0.02011 145 Genes annotated by the GO term GO:0045892. Any process that stops prevents or reduces the frequency rate or extent of DNA-dependent transcription. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS View Gene Set 0.003558 127 0.02011 145 Genes annotated by the GO term GO:0051253. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving RNA. www.broad.mit.e...
Broad PROTEOLYSIS View Gene Set 0.003995 187 0.02207 147 Genes annotated by the GO term GO:0006508. The hydrolysis of a peptide bond or bonds within a protein. www.broad.mit.e...
Broad RNA_EXPORT_FROM_NUCLEUS View Gene Set 0.00398 20 0.02207 147 Genes annotated by the GO term GO:0006405. The directed movement of RNA from the nucleus to the cytoplasm. www.broad.mit.e...
Broad RNA_CATABOLIC_PROCESS View Gene Set 0.004012 22 0.02207 147 Genes annotated by the GO term GO:0006401. The chemical reactions and pathways resulting in the breakdown of RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. www.broad.mit.e...
Broad G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE View Gene Set 0.003989 27 0.02207 147 Genes annotated by the GO term GO:0000082. Progression from G1 phase to S phase of the mitotic cell cycle. www.broad.mit.e...
Broad DNA_DAMAGE_CHECKPOINT View Gene Set 0.004071 20 0.02224 151 Genes annotated by the GO term GO:0000077. A signal transduction pathway induced by DNA damage that blocks cell cycle progression (in G1 G2 or metaphase) or slows the rate at which S phase proceeds. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_DNA_REPLICATION View Gene Set 0.004233 12 0.02297 152 Genes annotated by the GO term GO:0008156. Any process that stops prevents or reduces the frequency rate or extent of DNA replication. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS View Gene Set 0.004425 17 0.02386 153 Genes annotated by the GO term GO:0051053. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving DNA. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_CELLULAR_METABOLIC_PROCESS View Gene Set 0.004813 252 0.02578 154 Genes annotated by the GO term GO:0031324. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. www.broad.mit.e...
Broad PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS View Gene Set 0.005441 9 0.02896 155 Genes annotated by the GO term GO:0006220. The chemical reactions and pathways involving a pyrimidine nucleotide a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. www.broad.mit.e...
Broad CELLULAR_RESPIRATION View Gene Set 0.005746 19 0.03038 156 Genes annotated by the GO term GO:0045333. The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). www.broad.mit.e...
Broad AEROBIC_RESPIRATION View Gene Set 0.006296 15 0.03308 157 Genes annotated by the GO term GO:0009060. The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. www.broad.mit.e...
Broad CHROMATIN_REMODELING View Gene Set 0.006374 23 0.03328 158 Genes annotated by the GO term GO:0006338. Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. www.broad.mit.e...
Broad DNA_REPLICATION_INITIATION View Gene Set 0.006705 15 0.03475 159 Genes annotated by the GO term GO:0006270. The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix the recruitment of DNA polymerases and the initiation of polymerase action. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_METABOLIC_PROCESS View Gene Set 0.006744 255 0.03475 159 Genes annotated by the GO term GO:0009892. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways within a cell or an organism. www.broad.mit.e...
Broad DNA_PACKAGING View Gene Set 0.006782 34 0.03475 159 Genes annotated by the GO term GO:0006323. Any process by which DNA and associated proteins are formed into a compact orderly structure. www.broad.mit.e...
Broad COFACTOR_BIOSYNTHETIC_PROCESS View Gene Set 0.006826 21 0.03476 162 Genes annotated by the GO term GO:0051188. The chemical reactions and pathways resulting in the formation of a cofactor a substance that is required for the activity of an enzyme or other protein. www.broad.mit.e...
Broad DNA_DAMAGE_RESPONSESIGNAL_TRANSDUCTION View Gene Set 0.007139 34 0.03614 163 Genes annotated by the GO term GO:0042770. A cascade of processes induced by the detection of DNA damage within a cell. www.broad.mit.e...
Broad REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE View Gene Set 0.007429 86 0.03737 164 Genes annotated by the GO term GO:0043122. Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade. www.broad.mit.e...
Broad VIRAL_GENOME_REPLICATION View Gene Set 0.008046 21 0.04023 165 Genes annotated by the GO term GO:0019079. Any process involved directly in viral genome replication including viral nucleotide metabolism. www.broad.mit.e...
Broad CELL_DIVISION View Gene Set 0.008205 21 0.04078 166 Genes annotated by the GO term GO:0051301. The processes resulting in the physical partitioning and separation of a cell into daughter cells. www.broad.mit.e...
Broad PIGMENT_METABOLIC_PROCESS View Gene Set 0.008458 18 0.04179 167 Genes annotated by the GO term GO:0042440. The chemical reactions and pathways involving pigment any general or particular coloring matter in living organisms e.g. melanin. www.broad.mit.e...
Broad CELL_PROLIFERATION_GO_0008283 View Gene Set 0.008705 501 0.04275 168 Genes annotated by the GO term GO:0008283. The multiplication or reproduction of cells resulting in the expansion of a cell population. www.broad.mit.e...
Broad POSITIVE_REGULATION_OF_CELLULAR_PROCESS View Gene Set 0.009285 644 0.04533 169 Genes annotated by the GO term GO:0048522. Any process that activates or increases the frequency rate or extent of cellular processes those that are carried out at the cellular level but are not necessarily restricted to a single cell. For example cell communication occurs among more than one cell but occurs at the cellular level. www.broad.mit.e...
Broad COVALENT_CHROMATIN_MODIFICATION View Gene Set 0.00946 23 0.04591 170 Genes annotated by the GO term GO:0016569. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. www.broad.mit.e...
Broad N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION View Gene Set 0.009973 6 0.04812 171 Genes annotated by the GO term GO:0031365. The alteration of the N-terminal amino acid residue in a protein. www.broad.mit.e...
Broad MICROTUBULE_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.01012 34 0.04856 172 Genes annotated by the GO term GO:0000226. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. www.broad.mit.e...
Broad TRNA_PROCESSING View Gene Set 0.01049 10 0.04973 173 Genes annotated by the GO term GO:0008033. The process by which a pre-tRNA molecule is converted to a mature tRNA ready for addition of an aminoacyl group. www.broad.mit.e...
Broad NITROGEN_COMPOUND_CATABOLIC_PROCESS View Gene Set 0.01046 28 0.04973 173 Genes annotated by the GO term GO:0044270. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. www.broad.mit.e...

Gene Set Collection: Broad.c5.CC

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad NUCLEUS View Gene Set 2.099e-70 1353 4.891e-68 1 Genes annotated by the GO term GO:0005634. A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells the nucleus contains all of the cell's chromosomes except the organellar chromosomes and is the site of RNA synthesis and processing. In some species or in specialized cell types RNA metabolism or DNA replication may be absent. www.broad.mit.e...
Broad INTRACELLULAR_ORGANELLE_PART View Gene Set 3.364e-64 1144 3.919e-62 2 Genes annotated by the GO term GO:0044446. A constituent part of an intracellular organelle an organized structure of distinctive morphology and function occurring within the cell. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad ORGANELLE_PART View Gene Set 4.772e-63 1149 3.706e-61 3 Genes annotated by the GO term GO:0044422. Any constituent part of an organelle an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad CYTOPLASM View Gene Set 1.012e-53 2054 5.895e-52 4 Genes annotated by the GO term GO:0005737. All of the contents of a cell excluding the plasma membrane and nucleus but including other subcellular structures. www.broad.mit.e...
Broad CYTOPLASMIC_PART View Gene Set 2.976e-41 1350 1.387e-39 5 Genes annotated by the GO term GO:0044444. Any constituent part of the cytoplasm all of the contents of a cell excluding the plasma membrane and nucleus but including other subcellular structures. www.broad.mit.e...
Broad NUCLEAR_PART View Gene Set 3.609e-41 543 1.402e-39 6 Genes annotated by the GO term GO:0044428. Any constituent part of the nucleus a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX View Gene Set 1.489e-32 914 4.956e-31 7 Genes annotated by the GO term GO:0032991. A stable assembly of two or more macromolecules i.e. proteins nucleic acids carbohydrates or lipids in which the constituent parts function together. www.broad.mit.e...
Broad ORGANELLE_LUMEN View Gene Set 1.072e-31 434 2.774e-30 8 Genes annotated by the GO term GO:0043233. The volume enclosed by the membranes of a particular organelle e.g. endoplasmic reticulum lumen or the space between the two lipid bilayers of a double membrane surrounding an organelle e.g. nuclear membrane lumen. www.broad.mit.e...
Broad MEMBRANE_ENCLOSED_LUMEN View Gene Set 1.072e-31 434 2.774e-30 8 Genes annotated by the GO term GO:0031974. The enclosed volume within a sealed membrane or between two sealed membranes. www.broad.mit.e...
Broad MITOCHONDRION View Gene Set 7.617e-27 335 1.775e-25 10 Genes annotated by the GO term GO:0005739. A semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX View Gene Set 7.642e-26 129 1.619e-24 11 Genes annotated by the GO term GO:0030529. A macromolecular complex containing both protein and RNA molecules. www.broad.mit.e...
Broad NUCLEAR_LUMEN View Gene Set 2.684e-24 365 5.211e-23 12 Genes annotated by the GO term GO:0031981. The volume enclosed by the nuclear inner membrane. www.broad.mit.e...
Broad ORGANELLE_MEMBRANE View Gene Set 1.468e-22 290 2.631e-21 13 Genes annotated by the GO term GO:0031090. The lipid bilayer surrounding an organelle. www.broad.mit.e...
Broad NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 1.118e-21 613 1.737e-20 14 Genes annotated by the GO term GO:0043228. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad INTRACELLULAR_NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 1.118e-21 613 1.737e-20 14 Genes annotated by the GO term GO:0043232. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad ENVELOPE View Gene Set 1.986e-21 165 2.722e-20 16 Genes annotated by the GO term GO:0031975. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers and may include a cell wall layer also includes the space between layers. www.broad.mit.e...
Broad ORGANELLE_ENVELOPE View Gene Set 1.986e-21 165 2.722e-20 16 Genes annotated by the GO term GO:0031967. A double membrane structure enclosing an organelle including two lipid bilayers and the region between them. In some cases an organelle envelope may have more than two membranes. www.broad.mit.e...
Broad PROTEIN_COMPLEX View Gene Set 2.64e-19 799 3.417e-18 18 Genes annotated by the GO term GO:0043234. Any protein group composed of two or more subunits which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad MITOCHONDRIAL_PART View Gene Set 4.573e-19 140 5.608e-18 19 Genes annotated by the GO term GO:0044429. Any constituent part of a mitochondrion a semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad NUCLEOLUS View Gene Set 3.868e-16 116 4.506e-15 20 Genes annotated by the GO term GO:0005730. A small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA the processing of this RNA into 5.8S 18S and 28S components of ribosomal RNA and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. www.broad.mit.e...
Broad CHROMOSOME View Gene Set 7.84e-16 122 8.699e-15 21 Genes annotated by the GO term GO:0005694. A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad ENDOMEMBRANE_SYSTEM View Gene Set 3.66e-15 213 3.876e-14 22 Genes annotated by the GO term GO:0012505. A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum Golgi bodies vesicles cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. www.broad.mit.e...
Broad CHROMOSOMAL_PART View Gene Set 1.555e-13 95 1.576e-12 23 Genes annotated by the GO term GO:0044427. Any constituent part of a chromosome a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad NUCLEOPLASM View Gene Set 2.508e-13 266 2.435e-12 24 Genes annotated by the GO term GO:0005654. That part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE View Gene Set 5.91e-13 85 5.508e-12 25 Genes annotated by the GO term GO:0031966. Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM View Gene Set 9.076e-13 282 8.134e-12 26 Genes annotated by the GO term GO:0005783. The irregular network of unit membranes visible only by electron microscopy that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels which are often expanded into slitlike cavities called cisternae. The ER takes two forms rough (or granular) with ribosomes adhering to the outer surface and smooth (with no ribosomes attached). www.broad.mit.e...
Broad MITOCHONDRIAL_ENVELOPE View Gene Set 2.112e-12 95 1.823e-11 27 Genes annotated by the GO term GO:0005740. The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. www.broad.mit.e...
Broad ORGANELLE_INNER_MEMBRANE View Gene Set 6.737e-11 74 5.606e-10 28 Genes annotated by the GO term GO:0019866. The inner i.e. lumen-facing lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. www.broad.mit.e...
Broad MITOCHONDRIAL_INNER_MEMBRANE View Gene Set 9.488e-11 66 7.623e-10 29 Genes annotated by the GO term GO:0005743. The inner i.e. lumen-facing lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. www.broad.mit.e...
Broad NUCLEAR_ENVELOPE View Gene Set 1.999e-10 71 1.553e-09 30 Genes annotated by the GO term GO:0005635. The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space a gap of width 20-40 nm (also called the perinuclear space). www.broad.mit.e...
Broad SPLICEOSOME View Gene Set 3.574e-10 44 2.686e-09 31 Genes annotated by the GO term GO:0005681. A ribonucleoprotein complex containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. www.broad.mit.e...
Broad NUCLEOPLASM_PART View Gene Set 9.791e-10 202 7.129e-09 32 Genes annotated by the GO term GO:0044451. Any constituent part of the nucleoplasm that part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad RIBOSOME View Gene Set 1.018e-09 39 7.187e-09 33 Genes annotated by the GO term GO:0005840. An intracellular organelle about 200 A in diameter consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits one large and one small each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients expressed in Svedberg units (symbol: S). Hence the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes eukaryotes mitochondria and chloroplasts have characteristically distinct ribosomal proteins. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE View Gene Set 4.86e-09 48 3.33e-08 34 Genes annotated by the GO term GO:0031965. Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. www.broad.mit.e...
Broad MITOCHONDRIAL_MATRIX View Gene Set 1.082e-08 46 7.001e-08 35 Genes annotated by the GO term GO:0005759. The gel-like material with considerable fine structure that lies in the matrix space or lumen of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and in some organisms the enzymes concerned with fatty-acid oxidation. www.broad.mit.e...
Broad MITOCHONDRIAL_LUMEN View Gene Set 1.082e-08 46 7.001e-08 35 Genes annotated by the GO term GO:0031980. The volume enclosed by the mitochondrial inner membrane. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE_PART View Gene Set 1.145e-08 40 7.211e-08 37 Genes annotated by the GO term GO:0044453. Any constituent part of the nuclear membrane the envelope that surrounds the nucleus of eukaryotic cells. www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE_PART View Gene Set 3.613e-08 52 2.216e-07 38 Genes annotated by the GO term GO:0044455. Any constituent part of the mitochondrial membrane either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 4.02e-08 20 2.402e-07 39 Genes annotated by the GO term GO:0030532. A complex composed of RNA of the small nuclear RNA (snRNA) class and protein found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain e.g. U1 snRNP or U4/U6 snRNP. Many but not all of these complexes are involved in splicing of nuclear mRNAs. www.broad.mit.e...
Broad NUCLEAR_PORE View Gene Set 6.793e-08 29 3.957e-07 40 Genes annotated by the GO term GO:0005643. Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell where the inner and outer nuclear membranes are joined. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_PART View Gene Set 1.077e-07 93 6.119e-07 41 Genes annotated by the GO term GO:0044432. Any constituent part of the endoplasmic reticulum the irregular network of unit membranes visible only by electron microscopy that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels which are often expanded into slitlike cavities called cisternae. www.broad.mit.e...
Broad CHROMOSOMEPERICENTRIC_REGION View Gene Set 2.425e-07 31 1.345e-06 42 Genes annotated by the GO term GO:0000775. The central region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes this region corresponds to a single area of the chromosome whereas in holocentric chromosomes it is evenly distributed along the chromosome. www.broad.mit.e...
Broad CHROMATIN View Gene Set 6.178e-07 35 3.271e-06 43 Genes annotated by the GO term GO:0000785. The ordered and organized complex of DNA and protein that forms the chromosome. www.broad.mit.e...
Broad PORE_COMPLEX View Gene Set 6.046e-07 34 3.271e-06 43 Genes annotated by the GO term GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids. www.broad.mit.e...
Broad SPINDLE View Gene Set 1.384e-06 37 7.164e-06 45 Genes annotated by the GO term GO:0005819. The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. www.broad.mit.e...
Broad HETEROGENEOUS_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 2.099e-06 9 1.063e-05 46 Genes annotated by the GO term GO:0030530. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II that which is translated into protein) with protein which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. www.broad.mit.e...
Broad NUCLEAR_ENVELOPE_ENDOPLASMIC_RETICULUM_NETWORK View Gene Set 2.639e-06 91 1.308e-05 47 Genes annotated by the GO term GO:0042175. The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum. www.broad.mit.e...
Broad KINETOCHORE View Gene Set 3.586e-06 25 1.74e-05 48 Genes annotated by the GO term GO:0000776. A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME View Gene Set 5.125e-06 53 2.388e-05 49 Genes annotated by the GO term GO:0000228. A chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 5.119e-06 82 2.388e-05 49 Genes annotated by the GO term GO:0005789. The lipid bilayer surrounding the endoplasmic reticulum. www.broad.mit.e...
Broad ORGANELLAR_RIBOSOME View Gene Set 1.047e-05 22 4.691e-05 51 Genes annotated by the GO term GO:0000313. A ribosome contained within a subcellular organelle. www.broad.mit.e...
Broad MITOCHONDRIAL_RIBOSOME View Gene Set 1.047e-05 22 4.691e-05 51 Genes annotated by the GO term GO:0005761. A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. www.broad.mit.e...
Broad RIBOSOMAL_SUBUNIT View Gene Set 1.092e-05 20 4.8e-05 53 Genes annotated by the GO term GO:0033279. Either of the two ribonucleoprotein complexes that associate to form a ribosome. www.broad.mit.e...
Broad NUCLEOLAR_PART View Gene Set 2.642e-05 16 0.000114 54 Genes annotated by the GO term GO:0044452. Any constituent part of a nucleolus a small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. www.broad.mit.e...
Broad GOLGI_APPARATUS View Gene Set 4.064e-05 222 0.0001722 55 Genes annotated by the GO term GO:0005794. A compound membranous cytoplasmic organelle of eukaryotic cells consisting of flattened ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle while in invertebrates and plants where they are known usually as dictyosomes there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis in the vicinity of the cis face trans in the vicinity of the trans face and medial lying between the cis and trans regions. www.broad.mit.e...
Broad GOLGI_APPARATUS_PART View Gene Set 4.535e-05 98 0.0001887 56 Genes annotated by the GO term GO:0044431. Any constituent part of the Golgi apparatus a compound membranous cytoplasmic organelle of eukaryotic cells consisting of flattened ribosome-free vesicles arranged in a more or less regular stack. www.broad.mit.e...
Broad PROTEASOME_COMPLEX View Gene Set 5.014e-05 23 0.0002048 57 Genes annotated by the GO term GO:0000502. A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. www.broad.mit.e...
Broad CONDENSED_CHROMOSOME View Gene Set 5.099e-05 32 0.0002048 57 Genes annotated by the GO term GO:0000793. A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. www.broad.mit.e...
Broad OLIGOSACCHARYL_TRANSFERASE_COMPLEX View Gene Set 7.445e-05 9 0.000294 59 Genes annotated by the GO term GO:0008250. A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits at least in yeast. www.broad.mit.e...
Broad SPINDLE_MICROTUBULE View Gene Set 7.995e-05 15 0.0003105 60 Genes annotated by the GO term GO:0005876. Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. www.broad.mit.e...
Broad MICROBODY View Gene Set 0.0001059 46 0.0003979 61 Genes annotated by the GO term GO:0042579. Cytoplasmic organelles spherical or oval in shape that are bounded by a single membrane and contain oxidative enzymes especially those utilizing hydrogen peroxide (H2O2). www.broad.mit.e...
Broad PEROXISOME View Gene Set 0.0001059 46 0.0003979 61 Genes annotated by the GO term GO:0005777. A small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). www.broad.mit.e...
Broad TRANSCRIPTION_FACTOR_COMPLEX View Gene Set 0.0001091 84 0.0004034 63 Genes annotated by the GO term GO:0005667. Any complex distinct from RNA polymerase including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences and regulating transcription. www.broad.mit.e...
Broad ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001498 11 0.0005211 64 Genes annotated by the GO term GO:0000314. The smaller of the two subunits of an organellar ribosome. www.broad.mit.e...
Broad MITOCHONDRIAL_SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001498 11 0.0005211 64 Genes annotated by the GO term GO:0005763. The smaller of the two subunits of a mitochondrial ribosome. www.broad.mit.e...
Broad MICROTUBULE_CYTOSKELETON View Gene Set 0.0001462 146 0.0005211 64 Genes annotated by the GO term GO:0015630. The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. www.broad.mit.e...
Broad SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001498 11 0.0005211 64 Genes annotated by the GO term GO:0015935. The smaller of the two subunits of a ribosome. www.broad.mit.e...
Broad ER_GOLGI_INTERMEDIATE_COMPARTMENT View Gene Set 0.0002141 22 0.0007337 68 Genes annotated by the GO term GO:0005793. A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex with a distinctive membrane protein composition; involved in ER-to-Golgi transport. www.broad.mit.e...
Broad EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX View Gene Set 0.0002366 10 0.0007988 69 Genes annotated by the GO term GO:0005852. A complex of several polypeptides that plays at least two important roles in protein synthesis: First eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. www.broad.mit.e...
Broad CYTOPLASMIC_VESICLE_MEMBRANE View Gene Set 0.000255 26 0.0008367 70 Genes annotated by the GO term GO:0030659. The lipid bilayer surrounding a cytoplasmic vesicle. www.broad.mit.e...
Broad CYTOPLASMIC_VESICLE_PART View Gene Set 0.000255 26 0.0008367 70 Genes annotated by the GO term GO:0044433. Any constituent part of cytoplasmic vesicle a vesicle formed of membrane or protein found in the cytoplasm of a cell. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME_PART View Gene Set 0.0002837 33 0.000918 72 Genes annotated by the GO term GO:0044454. Any constituent part of a nuclear chromosome a chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad VESICLE_MEMBRANE View Gene Set 0.0005825 28 0.001859 73 Genes annotated by the GO term GO:0012506. The lipid bilayer surrounding any membrane-bounded vesicle in the cell. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_LUMEN View Gene Set 0.0006303 12 0.001985 74 Genes annotated by the GO term GO:0005788. The volume enclosed by the membranes of the endoplasmic reticulum. www.broad.mit.e...
Broad GOLGI_ASSOCIATED_VESICLE View Gene Set 0.0006392 27 0.001986 75 Genes annotated by the GO term GO:0005798. Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. www.broad.mit.e...
Broad MICROTUBULE View Gene Set 0.0006804 31 0.002086 76 Genes annotated by the GO term GO:0005874. Any of the long generally straight hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation e.g. in the spindle. www.broad.mit.e...
Broad NUCLEAR_BODY View Gene Set 0.0007139 31 0.00216 77 Genes annotated by the GO term GO:0016604. Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. www.broad.mit.e...
Broad OUTER_MEMBRANE View Gene Set 0.0009436 25 0.002819 78 Genes annotated by the GO term GO:0019867. The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. www.broad.mit.e...
Broad NUCLEAR_CHROMATIN View Gene Set 0.00102 14 0.003008 79 Genes annotated by the GO term GO:0000790. The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus. www.broad.mit.e...
Broad PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX View Gene Set 0.001195 15 0.003481 80 Genes annotated by the GO term GO:0016469. A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0 V0 or A0) that carries out proton transport and a cytoplasmic compartment sector (F1 V1 or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient whereas F-type ATPases also known as ATP synthases normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type A-type ATPases have been found in archaea and are closely related to eukaryotic V-type ATPases but are reversible. www.broad.mit.e...
Broad UBIQUITIN_LIGASE_COMPLEX View Gene Set 0.001613 26 0.004641 81 Genes annotated by the GO term GO:0000151. A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex. www.broad.mit.e...
Broad REPLICATION_FORK View Gene Set 0.002097 18 0.005959 82 Genes annotated by the GO term GO:0005657. The Y-shaped region of a replicating DNA molecule resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. www.broad.mit.e...
Broad ORGANELLE_OUTER_MEMBRANE View Gene Set 0.002382 24 0.006687 83 Genes annotated by the GO term GO:0031968. The outer i.e. cytoplasm-facing lipid bilayer of an organelle envelope. www.broad.mit.e...
Broad DNA_DIRECTED_RNA_POLYMERASEII_HOLOENZYME View Gene Set 0.002505 65 0.006949 84 Genes annotated by the GO term GO:0016591. Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA D E F and H which are required for promoter recognition and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. www.broad.mit.e...
Broad MITOCHONDRIAL_RESPIRATORY_CHAIN View Gene Set 0.003162 24 0.008667 85 Genes annotated by the GO term GO:0005746. The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I III and IV can transport protons if embedded in an oriented membrane such as an intact mitochondrial inner membrane. www.broad.mit.e...
Broad PERINUCLEAR_REGION_OF_CYTOPLASM View Gene Set 0.003205 55 0.008682 86 Genes annotated by the GO term GO:0048471. Cytoplasm situated near or occurring around the nucleus. www.broad.mit.e...
Broad MITOCHONDRIAL_OUTER_MEMBRANE View Gene Set 0.003494 18 0.009358 87 Genes annotated by the GO term GO:0005741. The outer i.e. cytoplasm-facing lipid bilayer of the mitochondrial envelope. www.broad.mit.e...
Broad CYTOSKELETON View Gene Set 0.003596 359 0.009521 88 Genes annotated by the GO term GO:0005856. Any of the various filamentous elements that form the internal framework of cells and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments microfilaments microtubules the microtrabecular lattice and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions including cellular movement cell division endocytosis and movement of organelles. www.broad.mit.e...
Broad SPINDLE_POLE View Gene Set 0.003793 17 0.00993 89 Genes annotated by the GO term GO:0000922. Either of the ends of a spindle where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules spindle microtubules and astral microtubules. www.broad.mit.e...
Broad U12_DEPENDENT_SPLICEOSOME View Gene Set 0.005089 7 0.01318 90 Genes annotated by the GO term GO:0005689. The minor (U12-dependent) spliceosome is composed of the snRNPs U11 U12 U4atac U6atac and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides as well as other non-canonical introns. The entire splice site signal not just the terminal dinucleotides is involved in determining which spliceosome utilizes the site. www.broad.mit.e...
Broad GOLGI_MEMBRANE View Gene Set 0.005409 43 0.01327 91 Genes annotated by the GO term GO:0000139. The lipid bilayer surrounding any of the compartments of the Golgi apparatus. www.broad.mit.e...
Broad VESICLE_COAT View Gene Set 0.005365 15 0.01327 91 Genes annotated by the GO term GO:0030120. A membrane coat found on a coated vesicle. www.broad.mit.e...
Broad COATED_VESICLE_MEMBRANE View Gene Set 0.005365 15 0.01327 91 Genes annotated by the GO term GO:0030662. The lipid bilayer surrounding a coated vesicle. www.broad.mit.e...
Broad MEMBRANE_COAT View Gene Set 0.005365 16 0.01327 91 Genes annotated by the GO term GO:0030117. Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex the COPI and COPII complexes and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. www.broad.mit.e...
Broad COATED_MEMBRANE View Gene Set 0.005365 16 0.01327 91 Genes annotated by the GO term GO:0048475. A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex the COPI and COPII complexes. www.broad.mit.e...
Broad ENDOSOME View Gene Set 0.006915 64 0.01678 96 Genes annotated by the GO term GO:0005768. A membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation. www.broad.mit.e...
Broad CYTOSKELETAL_PART View Gene Set 0.007103 231 0.01706 97 Genes annotated by the GO term GO:0044430. Any constituent part of the cytoskeleton a cellular scaffolding or skeleton that maintains cell shape enables some cell motion (using structures such as flagella and cilia) and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments microfilaments microtubules and the microtrabecular lattice. www.broad.mit.e...
Broad MICROTUBULE_ORGANIZING_CENTER View Gene Set 0.007489 64 0.01781 98 Genes annotated by the GO term GO:0005815. A region in a eukaryotic cell such as a centrosome or basal body from which microtubules grow. www.broad.mit.e...
Broad COATED_VESICLE View Gene Set 0.008207 45 0.01932 99 Genes annotated by the GO term GO:0030135. Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin whereas others are made from other proteins. www.broad.mit.e...
Broad EARLY_ENDOSOME View Gene Set 0.008343 18 0.01944 100 Genes annotated by the GO term GO:0005769. Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered. www.broad.mit.e...
Broad CENTROSOME View Gene Set 0.008779 55 0.02025 101 Genes annotated by the GO term GO:0005813. A structure comprised of a core structure (in most organisms a pair of centrioles) and peripheral material from which a microtubule-based structure such as a spindle apparatus is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells though in animal cells it changes continually during the cell-division cycle. www.broad.mit.e...
Broad INTRINSIC_TO_ORGANELLE_MEMBRANE View Gene Set 0.008994 51 0.02055 102 Genes annotated by the GO term GO:0031300. Located in an organelle membrane such that some covalently attached portion of the gene product for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor spans or is embedded in one or both leaflets of the membrane. www.broad.mit.e...
Broad NUCLEAR_REPLICATION_FORK View Gene Set 0.01035 10 0.02341 103 Genes annotated by the GO term GO:0043596. The Y-shaped region of a nuclear replicating DNA molecule resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. www.broad.mit.e...
Broad INTRINSIC_TO_ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 0.01171 24 0.02598 104 Genes annotated by the GO term GO:0031227. Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor spans or is embedded in one or both leaflets of the membrane. www.broad.mit.e...
Broad INTEGRAL_TO_ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 0.01171 24 0.02598 104 Genes annotated by the GO term GO:0030176. Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. www.broad.mit.e...
Broad NUCLEAR_SPECK View Gene Set 0.01421 10 0.03124 106 Genes annotated by the GO term GO:0016607. A discrete extra-nucleolar subnuclear domain 20-50 in number in which splicing factors are seen to be localized by immunofluorescence microscopy. www.broad.mit.e...
Broad TRANSPORT_VESICLE View Gene Set 0.01436 29 0.03127 107 Genes annotated by the GO term GO:0030133. Any of the vesicles of the constitutive secretory pathway which carry cargo from the endoplasmic reticulum to the Golgi between Golgi cisternae and to destinations within or outside the cell. www.broad.mit.e...
Broad INTEGRAL_TO_ORGANELLE_MEMBRANE View Gene Set 0.01647 49 0.03552 108 Genes annotated by the GO term GO:0031301. Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. www.broad.mit.e...
Broad DNA_DIRECTED_RNA_POLYMERASE_COMPLEX View Gene Set 0.0174 16 0.03652 109 Genes annotated by the GO term GO:0000428. A protein complex that possesses DNA-directed RNA polymerase activity. www.broad.mit.e...
Broad RNA_POLYMERASE_COMPLEX View Gene Set 0.0174 16 0.03652 109 Genes annotated by the GO term GO:0030880. Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. www.broad.mit.e...
Broad NUCLEAR_DNA_DIRECTED_RNA_POLYMERASE_COMPLEX View Gene Set 0.0174 16 0.03652 109 Genes annotated by the GO term GO:0055029. A protein complex located in the nucleus that possesses DNA-directed RNA polymerase activity. www.broad.mit.e...
Broad NADH_DEHYDROGENASE_COMPLEX View Gene Set 0.01966 15 0.04018 112 Genes annotated by the GO term GO:0030964. An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone. www.broad.mit.e...
Broad MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I View Gene Set 0.01966 15 0.04018 112 Genes annotated by the GO term GO:0005747. A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits including NADH dehydrogenase (ubiquinone) flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III) and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. www.broad.mit.e...
Broad RESPIRATORY_CHAIN_COMPLEX_I View Gene Set 0.01966 15 0.04018 112 Genes annotated by the GO term GO:0045271. Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. www.broad.mit.e...
Broad CYTOSOL View Gene Set 0.021 203 0.04254 115 Genes annotated by the GO term GO:0005829. That part of the cytoplasm that does not contain membranous or particulate subcellular components. www.broad.mit.e...

Gene Set Collection: Broad.c5.MF

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad RNA_BINDING View Gene Set 4.675e-35 236 1.851e-32 1 Genes annotated by the GO term GO:0003723. Interacting selectively with an RNA molecule or a portion thereof. www.broad.mit.e...
Broad STRUCTURAL_CONSTITUENT_OF_RIBOSOME View Gene Set 1.731e-19 80 3.426e-17 2 Genes annotated by the GO term GO:0003735. The action of a molecule that contributes to the structural integrity of the ribosome. www.broad.mit.e...
Broad TRANSLATION_FACTOR_ACTIVITY_NUCLEIC_ACID_BINDING View Gene Set 1.424e-11 39 1.88e-09 3 Genes annotated by the GO term GO:0008135. Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad TRANSLATION_REGULATOR_ACTIVITY View Gene Set 6.576e-11 41 6.51e-09 4 Genes annotated by the GO term GO:0045182. Any substance involved in the initiation activation perpetuation repression or termination of polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES View Gene Set 1.082e-10 224 8.569e-09 5 Genes annotated by the GO term GO:0016817. Catalysis of the hydrolysis of any acid anhydride. www.broad.mit.e...
Broad PYROPHOSPHATASE_ACTIVITY View Gene Set 2.872e-10 222 1.896e-08 6 Genes annotated by the GO term GO:0016462. Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups leaving one phosphate on each of the two fragments. www.broad.mit.e...
Broad TRANSLATION_INITIATION_FACTOR_ACTIVITY View Gene Set 4.393e-10 24 2.485e-08 7 Genes annotated by the GO term GO:0003743. Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. www.broad.mit.e...
Broad NUCLEOSIDE_TRIPHOSPHATASE_ACTIVITY View Gene Set 2.587e-09 208 1.281e-07 8 Genes annotated by the GO term GO:0017111. Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. www.broad.mit.e...
Broad STRUCTURE_SPECIFIC_DNA_BINDING View Gene Set 7.187e-09 55 3.162e-07 9 Genes annotated by the GO term GO:0043566. Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. www.broad.mit.e...
Broad UNFOLDED_PROTEIN_BINDING View Gene Set 1.272e-08 41 5.038e-07 10 Genes annotated by the GO term GO:0051082. Interacting selectively with an unfolded protein. www.broad.mit.e...
Broad DNA_BINDING View Gene Set 1.804e-08 587 6.494e-07 11 Genes annotated by the GO term GO:0003677. Interacting selectively with DNA (deoxyribonucleic acid). www.broad.mit.e...
Broad TRANSCRIPTION_FACTOR_BINDING View Gene Set 3.006e-08 300 9.919e-07 12 Genes annotated by the GO term GO:0008134. Interacting selectively with a transcription factor any protein required to initiate or regulate transcription. www.broad.mit.e...
Broad LIGASE_ACTIVITY View Gene Set 5.855e-08 97 1.783e-06 13 Genes annotated by the GO term GO:0016874. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. www.broad.mit.e...
Broad HELICASE_ACTIVITY View Gene Set 9.744e-08 49 2.756e-06 14 Genes annotated by the GO term GO:0004386. Catalysis of the unwinding of a DNA or RNA duplex. www.broad.mit.e...
Broad SINGLE_STRANDED_DNA_BINDING View Gene Set 4.773e-07 34 1.211e-05 15 Genes annotated by the GO term GO:0003697. Interacting selectively with single-stranded DNA. www.broad.mit.e...
Broad ATPASE_ACTIVITY View Gene Set 4.892e-07 109 1.211e-05 15 Genes annotated by the GO term GO:0016887. Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. www.broad.mit.e...
Broad ATP_DEPENDENT_HELICASE_ACTIVITY View Gene Set 1.383e-06 26 2.888e-05 17 Genes annotated by the GO term GO:0008026. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. www.broad.mit.e...
Broad DOUBLE_STRANDED_DNA_BINDING View Gene Set 1.385e-06 32 2.888e-05 17 Genes annotated by the GO term GO:0003690. Interacting selectively with double-stranded DNA. www.broad.mit.e...
Broad CHROMATIN_BINDING View Gene Set 1.3e-06 32 2.888e-05 17 Genes annotated by the GO term GO:0003682. Interacting selectively with chromatin the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. www.broad.mit.e...
Broad METHYLTRANSFERASE_ACTIVITY View Gene Set 1.897e-06 36 3.755e-05 20 Genes annotated by the GO term GO:0008168. Catalysis of the transfer of a methyl group to an acceptor molecule. www.broad.mit.e...
Broad SIGNAL_SEQUENCE_BINDING View Gene Set 2.185e-06 15 4.121e-05 21 Genes annotated by the GO term GO:0005048. Interacting selectively with a signal sequence a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. www.broad.mit.e...
Broad TRANSCRIPTION_COFACTOR_ACTIVITY View Gene Set 3.952e-06 222 7.113e-05 22 Genes annotated by the GO term GO:0003712. The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS View Gene Set 5.813e-06 37 0.0001001 23 Genes annotated by the GO term GO:0016741. Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad RNA_HELICASE_ACTIVITY View Gene Set 1.763e-05 24 0.000291 24 Genes annotated by the GO term GO:0003724. Catalysis of the unwinding of an RNA helix. www.broad.mit.e...
Broad DNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 1.912e-05 22 0.0003028 25 Genes annotated by the GO term GO:0008094. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. www.broad.mit.e...
Broad ATPASE_ACTIVITY_COUPLED View Gene Set 2.019e-05 92 0.0003075 26 Genes annotated by the GO term GO:0042623. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction for example ion transport across a membrane. www.broad.mit.e...
Broad RNA_SPLICING_FACTOR_ACTIVITYTRANSESTERIFICATION_MECHANISM View Gene Set 3.87e-05 14 0.0005677 27 Genes annotated by the GO term GO:0031202. An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced. www.broad.mit.e...
Broad RNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 4.633e-05 18 0.0006553 28 Genes annotated by the GO term GO:0008186. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of RNA; drives another reaction. www.broad.mit.e...
Broad MRNA_BINDING View Gene Set 0.0001001 22 0.001367 29 Genes annotated by the GO term GO:0003729. Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA). www.broad.mit.e...
Broad ATP_DEPENDENT_RNA_HELICASE_ACTIVITY View Gene Set 0.0001379 17 0.001813 30 Genes annotated by the GO term GO:0004004. Catalysis of the reaction: ATP + H2O = ADP + phosphate driving the unwinding of an RNA helix. www.broad.mit.e...
Broad LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS View Gene Set 0.0001419 14 0.001813 30 Genes annotated by the GO term GO:0016875. Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage usually in a nucleoside triphosphate. www.broad.mit.e...
Broad ATP_DEPENDENT_DNA_HELICASE_ACTIVITY View Gene Set 0.0001959 11 0.002424 32 Genes annotated by the GO term GO:0004003. Catalysis of the reaction: ATP + H2O = ADP + phosphate driving the unwinding of the DNA helix. www.broad.mit.e...
Broad LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS View Gene Set 0.0002798 68 0.003358 33 Genes annotated by the GO term GO:0016879. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage usually in a nucleoside triphosphate. www.broad.mit.e...
Broad DNA_HELICASE_ACTIVITY View Gene Set 0.0003133 24 0.003649 34 Genes annotated by the GO term GO:0003678. Catalysis of the unwinding of a DNA duplex. www.broad.mit.e...
Broad NUCLEOTIDYLTRANSFERASE_ACTIVITY View Gene Set 0.0003657 47 0.004138 35 Genes annotated by the GO term GO:0016779. Catalysis of the transfer of a nucleotidyl group to a reactant. www.broad.mit.e...
Broad STRUCTURAL_MOLECULE_ACTIVITY View Gene Set 0.0004067 243 0.004474 36 Genes annotated by the GO term GO:0005198. The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. www.broad.mit.e...
Broad NUCLEASE_ACTIVITY View Gene Set 0.0006101 54 0.006484 37 Genes annotated by the GO term GO:0004518. Catalysis of the hydrolysis of ester linkages within nucleic acids. www.broad.mit.e...
Broad ENDONUCLEASE_ACTIVITY_GO_0016893 View Gene Set 0.0006222 11 0.006484 37 Genes annotated by the GO term GO:0016893. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. www.broad.mit.e...
Broad GTPASE_ACTIVITY View Gene Set 0.0006497 98 0.006597 39 Genes annotated by the GO term GO:0003924. Catalysis of the reaction: GTP + H2O = GDP + phosphate. www.broad.mit.e...
Broad ISOMERASE_ACTIVITY View Gene Set 0.0008482 34 0.008397 40 Genes annotated by the GO term GO:0016853. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. www.broad.mit.e...
Broad HORMONE_RECEPTOR_BINDING View Gene Set 0.0009948 29 0.009608 41 Genes annotated by the GO term GO:0051427. Interacting selectively with a receptor for hormones. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYLOTHER_THAN_METHYLGROUPS View Gene Set 0.00106 30 0.009759 42 Genes annotated by the GO term GO:0016765. Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad GENERAL_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY View Gene Set 0.00105 32 0.009759 42 Genes annotated by the GO term GO:0016251. Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB TFIID TFIIE TFIIF TFIIH and TATA-binding protein (TBF). www.broad.mit.e...
Broad RIBONUCLEASE_ACTIVITY View Gene Set 0.001207 25 0.01086 44 Genes annotated by the GO term GO:0004540. Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_BINDING View Gene Set 0.001339 9 0.01178 45 Genes annotated by the GO term GO:0043021. Interacting selectively with any complex of RNA and protein. www.broad.mit.e...
Broad TRANSCRIPTION_COACTIVATOR_ACTIVITY View Gene Set 0.001515 121 0.01305 46 Genes annotated by the GO term GO:0003713. The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself. www.broad.mit.e...
Broad NUCLEAR_HORMONE_RECEPTOR_BINDING View Gene Set 0.001627 28 0.01371 47 Genes annotated by the GO term GO:0035257. Interacting selectively with a nuclear hormone receptor a ligand-dependent receptor found in the nucleus of the cell. www.broad.mit.e...
Broad S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY View Gene Set 0.001781 23 0.0147 48 Genes annotated by the GO term GO:0008757. Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. www.broad.mit.e...
Broad TRANSCRIPTION_COREPRESSOR_ACTIVITY View Gene Set 0.001839 91 0.01486 49 Genes annotated by the GO term GO:0003714. The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself. www.broad.mit.e...
Broad DAMAGED_DNA_BINDING View Gene Set 0.001952 21 0.01546 50 Genes annotated by the GO term GO:0003684. Interacting selectively with damaged DNA. www.broad.mit.e...
Broad OXIDOREDUCTASE_ACTIVITY View Gene Set 0.00217 280 0.01652 51 Genes annotated by the GO term GO:0016491. Catalysis of an oxidation-reduction (redox) reaction a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized while the other acts as hydrogen or electron acceptor and becomes reduced. www.broad.mit.e...
Broad ENDONUCLEASE_ACTIVITY View Gene Set 0.002128 25 0.01652 51 Genes annotated by the GO term GO:0004519. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS View Gene Set 0.00221 414 0.01652 51 Genes annotated by the GO term GO:0016772. Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad CHAPERONE_BINDING View Gene Set 0.002646 12 0.0194 54 Genes annotated by the GO term GO:0051087. Interacting selectively with a chaperone protein a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. www.broad.mit.e...
Broad NUCLEOTIDE_BINDING View Gene Set 0.003895 218 0.02754 55 Genes annotated by the GO term GO:0000166. Interacting selectively with a nucleotide any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. www.broad.mit.e...
Broad EXONUCLEASE_ACTIVITY View Gene Set 0.00387 18 0.02754 55 Genes annotated by the GO term GO:0004527. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. www.broad.mit.e...
Broad ENDORIBONUCLEASE_ACTIVITY View Gene Set 0.004059 13 0.0277 57 Genes annotated by the GO term GO:0004521. Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. www.broad.mit.e...
Broad PROTEIN_C_TERMINUS_BINDING View Gene Set 0.004127 73 0.0277 57 Genes annotated by the GO term GO:0008022. Interacting selectively with a protein C-terminus the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. www.broad.mit.e...
Broad THYROID_HORMONE_RECEPTOR_BINDING View Gene Set 0.004039 17 0.0277 57 Genes annotated by the GO term GO:0046966. Interacting selectively with a thyroid hormone receptor. www.broad.mit.e...
Broad NF_KAPPAB_BINDING View Gene Set 0.00447 11 0.0295 60 Genes annotated by the GO term GO:0051059. Interacting selectively with NF-kappaB a transcription factor for eukaryotic RNA polymerase II promoters. www.broad.mit.e...
Broad GTP_BINDING View Gene Set 0.004664 46 0.03017 61 Genes annotated by the GO term GO:0005525. Interacting selectively with GTP guanosine triphosphate. www.broad.mit.e...
Broad PROTEIN_TRANSPORTER_ACTIVITY View Gene Set 0.004728 14 0.03017 61 Genes annotated by the GO term GO:0008565. Enables the directed movement of proteins into out of within or between cells. www.broad.mit.e...
Broad N_METHYLTRANSFERASE_ACTIVITY View Gene Set 0.004877 13 0.03017 61 Genes annotated by the GO term GO:0008170. Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. www.broad.mit.e...
Broad GUANYL_NUCLEOTIDE_BINDING View Gene Set 0.004872 47 0.03017 61 Genes annotated by the GO term GO:0019001. Interacting selectively with guanyl nucleotides any compound consisting of guanosine esterified with (ortho)phosphate. www.broad.mit.e...
Broad PROTEIN_N_TERMINUS_BINDING View Gene Set 0.005177 38 0.03154 65 Genes annotated by the GO term GO:0047485. Interacting selectively with a protein N-terminus the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. www.broad.mit.e...
Broad TRANSCRIPTION_ACTIVATOR_ACTIVITY View Gene Set 0.00537 169 0.03222 66 Genes annotated by the GO term GO:0016563. Any transcription regulator activity required for initiation or upregulation of transcription. www.broad.mit.e...
Broad DOUBLE_STRANDED_RNA_BINDING View Gene Set 0.00634 17 0.03747 67 Genes annotated by the GO term GO:0003725. Interacting selectively with double-stranded RNA. www.broad.mit.e...
Broad ELECTRON_CARRIER_ACTIVITY View Gene Set 0.006536 76 0.03806 68 Genes annotated by the GO term GO:0009055. Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. www.broad.mit.e...
Broad PURINE_NUCLEOTIDE_BINDING View Gene Set 0.007525 205 0.04318 69 Genes annotated by the GO term GO:0017076. Interacting selectively with purine nucleotides any compound consisting of a purine nucleoside esterified with (ortho)phosphate. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS View Gene Set 0.007644 56 0.04324 70 Genes annotated by the GO term GO:0016746. Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad RNA_POLYMERASE_ACTIVITY View Gene Set 0.007813 16 0.04358 71 Genes annotated by the GO term GO:0034062. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. www.broad.mit.e...

Gene Set Collection: PMID

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
PMID 15635413 View Gene Set 5.199e-89 421 1.303e-85 1 Nucleolar proteome dynamics. www.ncbi.nlm.ni...
PMID 11790298 View Gene Set 2.547e-56 208 3.192e-53 2 Directed proteomic analysis of the human nucleolus. www.ncbi.nlm.ni...
PMID 17643375 View Gene Set 4.202e-50 391 3.512e-47 3 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. www.ncbi.nlm.ni...
PMID 15302935 View Gene Set 4.039e-47 773 2.532e-44 4 Large-scale characterization of HeLa cell nuclear phosphoproteins. www.ncbi.nlm.ni...
PMID 16964243 View Gene Set 4.191e-44 504 2.101e-41 5 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. www.ncbi.nlm.ni...
PMID 11042152 View Gene Set 7.636e-42 315 3.19e-39 6 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. www.ncbi.nlm.ni...
PMID 16565220 View Gene Set 2.287e-34 210 8.191e-32 7 Phosphoproteome analysis of the human mitotic spindle. www.ncbi.nlm.ni...
PMID 12226669 View Gene Set 7.925e-26 108 2.483e-23 8 Comprehensive proteomic analysis of the human spliceosome. www.ncbi.nlm.ni...
PMID 12429849 View Gene Set 1.027e-22 106 2.86e-20 9 Functional proteomic analysis of human nucleolus. www.ncbi.nlm.ni...
PMID 15592455 View Gene Set 2.187e-22 317 5.483e-20 10 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. www.ncbi.nlm.ni...
PMID 15189156 View Gene Set 4.016e-22 88 9.154e-20 11 The molecular mechanics of eukaryotic translation. www.ncbi.nlm.ni...
PMID 10810093 View Gene Set 7.688e-22 151 1.606e-19 12 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. www.ncbi.nlm.ni...
PMID 8722009 View Gene Set 1.396e-21 80 2.692e-19 13 Structure and evolution of mammalian ribosomal proteins. www.ncbi.nlm.ni...
PMID 15231747 View Gene Set 2.377e-21 212 4.257e-19 14 A protein interaction framework for human mRNA degradation. www.ncbi.nlm.ni...
PMID 12706105 View Gene Set 6.806e-21 182 1.137e-18 15 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. www.ncbi.nlm.ni...
PMID 17220478 View Gene Set 2.295e-19 63 3.597e-17 16 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. www.ncbi.nlm.ni...
PMID 9582194 View Gene Set 4.915e-18 67 7.248e-16 17 A map of 75 human ribosomal protein genes. www.ncbi.nlm.ni...
PMID 11543634 View Gene Set 1.02e-17 58 1.421e-15 18 The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. www.ncbi.nlm.ni...
PMID 12665801 View Gene Set 1.161e-17 261 1.531e-15 19 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. www.ncbi.nlm.ni...
PMID 12588972 View Gene Set 2.066e-16 56 2.467e-14 20 Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region. www.ncbi.nlm.ni...
PMID 16236267 View Gene Set 1.974e-16 77 2.467e-14 20 Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. www.ncbi.nlm.ni...
PMID 14559993 View Gene Set 5.322e-16 51 6.065e-14 22 Regulation of alternative splicing by SRrp86 and its interacting proteins. www.ncbi.nlm.ni...
PMID 16130169 View Gene Set 2.71e-14 74 2.954e-12 23 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. www.ncbi.nlm.ni...
PMID 15324660 View Gene Set 3.565e-14 242 3.575e-12 24 Proteomic functional and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. www.ncbi.nlm.ni...
PMID 16341674 View Gene Set 3.509e-14 392 3.575e-12 24 Transcriptome analysis of human gastric cancer. www.ncbi.nlm.ni...
PMID 14667819 View Gene Set 1.233e-13 112 1.185e-11 26 Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. www.ncbi.nlm.ni...
PMID 17148452 View Gene Set 1.276e-13 87 1.185e-11 26 Characterization of the interactome of the human MutL homologues MLH1 PMS1 and PMS2. www.ncbi.nlm.ni...
PMID 14567916 View Gene Set 1.371e-13 50 1.228e-11 28 Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. www.ncbi.nlm.ni...
PMID 11991638 View Gene Set 3.835e-13 74 3.315e-11 29 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. www.ncbi.nlm.ni...
PMID 20085707 View Gene Set 7.18e-13 42 6e-11 30 Aire's partners in the molecular control of immunological tolerance. www.ncbi.nlm.ni...
PMID 19710015 View Gene Set 1.233e-12 48 9.975e-11 31 The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. www.ncbi.nlm.ni...
PMID 11256614 View Gene Set 6.709e-12 522 5.256e-10 32 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. www.ncbi.nlm.ni...
PMID 15489336 View Gene Set 7.563e-12 722 5.745e-10 33 From ORFeome to biology: a functional genomics pipeline. www.ncbi.nlm.ni...
PMID 15231748 View Gene Set 1.004e-11 519 7.403e-10 34 Functional proteomics mapping of a human signaling pathway. www.ncbi.nlm.ni...
PMID 16381901 View Gene Set 1.315e-11 720 9.416e-10 35 The LIFEdb database in 2006. www.ncbi.nlm.ni...
PMID 17289661 View Gene Set 1.783e-11 35 1.242e-09 36 Molecular composition of IMP1 ribonucleoprotein granules. www.ncbi.nlm.ni...
PMID 19064571 View Gene Set 1.834e-11 75 1.243e-09 37 Polymorphisms in mitochondrial genes and prostate cancer risk. www.ncbi.nlm.ni...
PMID 15782174 View Gene Set 3.855e-11 31 2.543e-09 38 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. www.ncbi.nlm.ni...
PMID 7821789 View Gene Set 4.03e-11 59 2.59e-09 39 Construction of a human full-length cDNA bank. www.ncbi.nlm.ni...
PMID 11875025 View Gene Set 6.896e-11 41 4.322e-09 40 The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. www.ncbi.nlm.ni...
PMID 20508983 View Gene Set 7.607e-11 102 4.652e-09 41 Centrosome-related genes genetic variation and risk of breast cancer. www.ncbi.nlm.ni...
PMID 14743216 View Gene Set 8.441e-11 132 5.038e-09 42 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. www.ncbi.nlm.ni...
PMID 15952740 View Gene Set 1.376e-10 58 8.02e-09 43 Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. www.ncbi.nlm.ni...
PMID 11285280 View Gene Set 2.456e-10 62 1.4e-08 44 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. www.ncbi.nlm.ni...
PMID 11230166 View Gene Set 8.011e-10 748 4.463e-08 45 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. www.ncbi.nlm.ni...
PMID 15009096 View Gene Set 8.72e-10 39 4.752e-08 46 Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex while BMI-1 is transiently co-localized with the centromeric region in interphase. www.ncbi.nlm.ni...
PMID 11101529 View Gene Set 1.133e-09 34 6.044e-08 47 Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. www.ncbi.nlm.ni...
PMID 11401437 View Gene Set 1.202e-09 27 6.28e-08 48 A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. www.ncbi.nlm.ni...
PMID 18377426 View Gene Set 1.332e-09 20 6.816e-08 49 Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. www.ncbi.nlm.ni...
PMID 10931946 View Gene Set 1.634e-09 118 8.193e-08 50 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. www.ncbi.nlm.ni...
PMID 12388589 View Gene Set 1.905e-09 17 9.366e-08 51 A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. www.ncbi.nlm.ni...
PMID 12234937 View Gene Set 2.795e-09 34 1.326e-07 52 Characterization of novel SF3b and 17S U2 snRNP proteins including a human Prp5p homologue and an SF3b DEAD-box protein. www.ncbi.nlm.ni...
PMID 18809582 View Gene Set 2.804e-09 25 1.326e-07 52 Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. www.ncbi.nlm.ni...
PMID 12228227 View Gene Set 7.339e-09 30 3.407e-07 54 Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. www.ncbi.nlm.ni...
PMID 9653160 View Gene Set 1.09e-08 36 4.969e-07 55 Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. www.ncbi.nlm.ni...
PMID 11279123 View Gene Set 1.295e-08 31 5.797e-07 56 The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 8619474 View Gene Set 1.371e-08 534 6.029e-07 57 A "double adaptor" method for improved shotgun library construction. www.ncbi.nlm.ni...
PMID 15883184 View Gene Set 1.542e-08 31 6.664e-07 58 Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. www.ncbi.nlm.ni...
PMID 9110174 View Gene Set 3.127e-08 528 1.329e-06 59 Large-scale concatenation cDNA sequencing. www.ncbi.nlm.ni...
PMID 15456888 View Gene Set 4.468e-08 24 1.867e-06 60 The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. www.ncbi.nlm.ni...
PMID 12962325 View Gene Set 4.718e-08 22 1.908e-06 61 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. www.ncbi.nlm.ni...
PMID 17081065 View Gene Set 4.644e-08 80 1.908e-06 61 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. www.ncbi.nlm.ni...
PMID 15146197 View Gene Set 4.922e-08 693 1.959e-06 63 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. www.ncbi.nlm.ni...
PMID 18162579 View Gene Set 5.338e-08 22 2.091e-06 64 Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. www.ncbi.nlm.ni...
PMID 12791985 View Gene Set 6.726e-08 37 2.594e-06 65 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. www.ncbi.nlm.ni...
PMID 12791267 View Gene Set 7.275e-08 50 2.763e-06 66 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. www.ncbi.nlm.ni...
PMID 11551941 View Gene Set 9.821e-08 26 3.675e-06 67 The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 1286669 View Gene Set 1.25e-07 28 4.609e-06 68 Human liver protein map: a reference database established by microsequencing and gel comparison. www.ncbi.nlm.ni...
PMID 19738611 View Gene Set 1.785e-07 39 6.392e-06 69 Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. www.ncbi.nlm.ni...
PMID 9878551 View Gene Set 1.781e-07 34 6.392e-06 69 cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. www.ncbi.nlm.ni...
PMID 8706699 View Gene Set 2.386e-07 35 8.425e-06 71 Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing and mass spectrometry. www.ncbi.nlm.ni...
PMID 15029244 View Gene Set 2.527e-07 57 8.799e-06 72 Mammalian Cdh1/Fzr mediates its own degradation. www.ncbi.nlm.ni...
PMID 18063578 View Gene Set 2.881e-07 31 9.896e-06 73 The layered structure of human mitochondrial DNA nucleoids. www.ncbi.nlm.ni...
PMID 1602151 View Gene Set 2.985e-07 99 1.011e-05 74 Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. www.ncbi.nlm.ni...
PMID 7584026 View Gene Set 3.422e-07 43 1.144e-05 75 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. www.ncbi.nlm.ni...
PMID 11076863 View Gene Set 3.702e-07 794 1.221e-05 76 DNA cloning using in vitro site-specific recombination. www.ncbi.nlm.ni...
PMID 15130578 View Gene Set 3.822e-07 22 1.244e-05 77 Why do cells need an assembly machine for RNA-protein complexes? www.ncbi.nlm.ni...
PMID 7788527 View Gene Set 4.298e-07 42 1.381e-05 78 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. www.ncbi.nlm.ni...
PMID 15504738 View Gene Set 5.339e-07 19 1.694e-05 79 Genes affecting the cell cycle growth maintenance and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. www.ncbi.nlm.ni...
PMID 11748230 View Gene Set 6.065e-07 17 1.89e-05 80 Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. www.ncbi.nlm.ni...
PMID 20522537 View Gene Set 6.105e-07 73 1.89e-05 80 Variation within DNA repair pathway genes and risk of multiple sclerosis. www.ncbi.nlm.ni...
PMID 9731529 View Gene Set 7.061e-07 24 2.159e-05 82 Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. www.ncbi.nlm.ni...
PMID 17540176 View Gene Set 7.405e-07 28 2.237e-05 83 The tumor suppressor PP2A Abeta regulates the RalA GTPase. www.ncbi.nlm.ni...
PMID 12171929 View Gene Set 7.923e-07 31 2.365e-05 84 A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. www.ncbi.nlm.ni...
PMID 16085932 View Gene Set 8.58e-07 18 2.531e-05 85 A novel evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. www.ncbi.nlm.ni...
PMID 11013263 View Gene Set 8.688e-07 16 2.533e-05 86 A novel nuclear receptor corepressor complex N-CoR contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. www.ncbi.nlm.ni...
PMID 19596235 View Gene Set 9.138e-07 85 2.633e-05 87 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. www.ncbi.nlm.ni...
PMID 16303743 View Gene Set 9.883e-07 427 2.816e-05 88 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. www.ncbi.nlm.ni...
PMID 9472028 View Gene Set 1.086e-06 12 3.059e-05 89 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. www.ncbi.nlm.ni...
PMID 14729942 View Gene Set 1.122e-06 18 3.125e-05 90 Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. www.ncbi.nlm.ni...
PMID 10725331 View Gene Set 1.474e-06 14 4.017e-05 91 Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. www.ncbi.nlm.ni...
PMID 11279069 View Gene Set 1.465e-06 15 4.017e-05 91 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. www.ncbi.nlm.ni...
PMID 11310559 View Gene Set 1.579e-06 17 4.256e-05 93 Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. www.ncbi.nlm.ni...
PMID 9763677 View Gene Set 1.934e-06 15 5.159e-05 94 Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. www.ncbi.nlm.ni...
PMID 20516191 View Gene Set 2.795e-06 12 7.377e-05 95 A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). www.ncbi.nlm.ni...
PMID 15835887 View Gene Set 2.827e-06 12 7.384e-05 96 Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61 TRAP and two potential new subunits. www.ncbi.nlm.ni...
PMID 11031247 View Gene Set 2.895e-06 51 7.482e-05 97 Secretory protein trafficking and organelle dynamics in living cells. www.ncbi.nlm.ni...
PMID 9878398 View Gene Set 3.033e-06 13 7.758e-05 98 Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. www.ncbi.nlm.ni...
PMID 14564014 View Gene Set 3.082e-06 47 7.805e-05 99 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. www.ncbi.nlm.ni...
PMID 9121429 View Gene Set 3.124e-06 39 7.832e-05 100 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. www.ncbi.nlm.ni...
PMID 7584044 View Gene Set 3.484e-06 41 8.648e-05 101 Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. www.ncbi.nlm.ni...
PMID 10893419 View Gene Set 3.985e-06 41 9.515e-05 102 Degradation of HIV-1 integrase by the N-end rule pathway. www.ncbi.nlm.ni...
PMID 12419264 View Gene Set 3.985e-06 41 9.515e-05 102 The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. www.ncbi.nlm.ni...
PMID 14550573 View Gene Set 3.985e-06 41 9.515e-05 102 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. www.ncbi.nlm.ni...
PMID 9079628 View Gene Set 3.985e-06 41 9.515e-05 102 HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. www.ncbi.nlm.ni...
PMID 7584028 View Gene Set 4.389e-06 37 0.0001038 106 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). www.ncbi.nlm.ni...
PMID 10766737 View Gene Set 4.463e-06 11 0.0001046 107 Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. www.ncbi.nlm.ni...
PMID 12493763 View Gene Set 4.764e-06 18 0.0001106 108 A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. www.ncbi.nlm.ni...
PMID 20496165 View Gene Set 4.817e-06 68 0.0001108 109 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. www.ncbi.nlm.ni...
PMID 10531003 View Gene Set 4.942e-06 15 0.0001126 110 Newly assembled snRNPs associate with coiled bodies before speckles suggesting a nuclear snRNP maturation pathway. www.ncbi.nlm.ni...
PMID 15383276 View Gene Set 5.036e-06 67 0.0001138 111 A protein interaction network links GIT1 an enhancer of huntingtin aggregation to Huntington's disease. www.ncbi.nlm.ni...
PMID 11714285 View Gene Set 5.71e-06 11 0.0001213 112 The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. www.ncbi.nlm.ni...
PMID 16055448 View Gene Set 5.71e-06 11 0.0001213 112 The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. www.ncbi.nlm.ni...
PMID 8052601 View Gene Set 5.71e-06 11 0.0001213 112 Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. www.ncbi.nlm.ni...
PMID 8078941 View Gene Set 5.71e-06 11 0.0001213 112 Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. www.ncbi.nlm.ni...
PMID 8188258 View Gene Set 5.71e-06 11 0.0001213 112 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. www.ncbi.nlm.ni...
PMID 8449960 View Gene Set 5.71e-06 11 0.0001213 112 Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. www.ncbi.nlm.ni...
PMID 9278442 View Gene Set 5.71e-06 11 0.0001213 112 Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant. www.ncbi.nlm.ni...
PMID 12840015 View Gene Set 5.761e-06 12 0.0001214 119 Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. www.ncbi.nlm.ni...
PMID 12614612 View Gene Set 6.195e-06 19 0.0001294 120 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. www.ncbi.nlm.ni...
PMID 16097034 View Gene Set 6.536e-06 36 0.0001354 121 Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. www.ncbi.nlm.ni...
PMID 12611891 View Gene Set 6.609e-06 40 0.0001358 122 The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. www.ncbi.nlm.ni...
PMID 15308636 View Gene Set 6.671e-06 25 0.000136 123 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32 a new cycling protein that interacts with human Erv46. www.ncbi.nlm.ni...
PMID 10601273 View Gene Set 6.998e-06 21 0.0001415 124 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein whereas export is due to a nuclear export signal sequence in glucokinase. www.ncbi.nlm.ni...
PMID 15707391 View Gene Set 7.815e-06 23 0.0001567 125 DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. www.ncbi.nlm.ni...
PMID 1574589 View Gene Set 8.011e-06 11 0.0001594 126 De novo purine nucleotide biosynthesis. www.ncbi.nlm.ni...
PMID 16620772 View Gene Set 8.272e-06 24 0.0001633 127 A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. www.ncbi.nlm.ni...
PMID 9150948 View Gene Set 8.451e-06 15 0.0001655 128 A two-dimensional gel database of human colon carcinoma proteins. www.ncbi.nlm.ni...
PMID 18715871 View Gene Set 8.986e-06 20 0.0001746 129 PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. www.ncbi.nlm.ni...
PMID 11829477 View Gene Set 9.339e-06 13 0.0001801 130 Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. www.ncbi.nlm.ni...
PMID 11714716 View Gene Set 9.454e-06 13 0.0001809 131 Gemin5 a novel WD repeat protein component of the SMN complex that binds Sm proteins. www.ncbi.nlm.ni...
PMID 11713266 View Gene Set 1.102e-05 12 0.0001971 132 The methylosome a 20S complex containing JBP1 and pICln produces dimethylarginine-modified Sm proteins. www.ncbi.nlm.ni...
PMID 11784859 View Gene Set 1.115e-05 16 0.0001971 132 Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). www.ncbi.nlm.ni...
PMID 12719574 View Gene Set 1.124e-05 42 0.0001971 132 Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. www.ncbi.nlm.ni...
PMID 12750511 View Gene Set 1.124e-05 42 0.0001971 132 Hypermutation of HIV-1 DNA in the absence of the Vif protein. www.ncbi.nlm.ni...
PMID 12830140 View Gene Set 1.124e-05 42 0.0001971 132 DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. www.ncbi.nlm.ni...
PMID 12840737 View Gene Set 1.124e-05 42 0.0001971 132 Good to CU. www.ncbi.nlm.ni...
PMID 12914693 View Gene Set 1.124e-05 42 0.0001971 132 Death by deamination: a novel host restriction system for HIV-1. www.ncbi.nlm.ni...
PMID 12920286 View Gene Set 1.124e-05 42 0.0001971 132 Virology. Weapons of mutational destruction. www.ncbi.nlm.ni...
PMID 14614829 View Gene Set 1.124e-05 42 0.0001971 132 The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. www.ncbi.nlm.ni...
PMID 8076819 View Gene Set 1.053e-05 37 0.0001971 132 The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. www.ncbi.nlm.ni...
PMID 9811770 View Gene Set 1.124e-05 42 0.0001971 132 An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. www.ncbi.nlm.ni...
PMID 9846577 View Gene Set 1.124e-05 42 0.0001971 132 Evidence for a newly discovered cellular anti-HIV-1 phenotype. www.ncbi.nlm.ni...
PMID 10851237 View Gene Set 1.229e-05 11 0.000214 144 Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). www.ncbi.nlm.ni...
PMID 11402041 View Gene Set 1.257e-05 16 0.0002172 145 Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. www.ncbi.nlm.ni...
PMID 15342556 View Gene Set 1.304e-05 737 0.0002239 146 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. www.ncbi.nlm.ni...
PMID 18954305 View Gene Set 1.359e-05 13 0.0002317 147 Structural basis and specificity of human otubain 1-mediated deubiquitination. www.ncbi.nlm.ni...
PMID 11531413 View Gene Set 1.459e-05 27 0.0002321 148 HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. www.ncbi.nlm.ni...
PMID 12167863 View Gene Set 1.466e-05 43 0.0002321 148 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. www.ncbi.nlm.ni...
PMID 12808465 View Gene Set 1.466e-05 43 0.0002321 148 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. www.ncbi.nlm.ni...
PMID 12808466 View Gene Set 1.466e-05 43 0.0002321 148 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. www.ncbi.nlm.ni...
PMID 12809610 View Gene Set 1.466e-05 43 0.0002321 148 DNA deamination mediates innate immunity to retroviral infection. www.ncbi.nlm.ni...
PMID 12970355 View Gene Set 1.466e-05 43 0.0002321 148 The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. www.ncbi.nlm.ni...
PMID 14527406 View Gene Set 1.466e-05 43 0.0002321 148 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. www.ncbi.nlm.ni...
PMID 14528300 View Gene Set 1.466e-05 43 0.0002321 148 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. www.ncbi.nlm.ni...
PMID 14528301 View Gene Set 1.466e-05 43 0.0002321 148 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. www.ncbi.nlm.ni...
PMID 14557625 View Gene Set 1.466e-05 43 0.0002321 148 The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15) a cellular inhibitor of virus infectivity. www.ncbi.nlm.ni...
PMID 15232106 View Gene Set 1.472e-05 30 0.0002321 148 Self-assembling protein microarrays. www.ncbi.nlm.ni...
PMID 17363900 View Gene Set 1.46e-05 14 0.0002321 148 The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. www.ncbi.nlm.ni...
PMID 17274640 View Gene Set 1.581e-05 30 0.0002478 160 A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. www.ncbi.nlm.ni...
PMID 15146077 View Gene Set 1.627e-05 32 0.0002519 161 The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. www.ncbi.nlm.ni...
PMID 18697920 View Gene Set 1.628e-05 14 0.0002519 161 The role of human ribosomal proteins in the maturation of rRNA and ribosome production. www.ncbi.nlm.ni...
PMID 10601333 View Gene Set 1.741e-05 12 0.0002677 163 Gemin3: A novel DEAD box protein that interacts with SMN the spinal muscular atrophy gene product and is a component of gems. www.ncbi.nlm.ni...
PMID 15142377 View Gene Set 1.763e-05 19 0.0002695 164 Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. www.ncbi.nlm.ni...
PMID 15761153 View Gene Set 2.287e-05 211 0.0003468 165 High-throughput mapping of a dynamic signaling network in mammalian cells. www.ncbi.nlm.ni...
PMID 8811196 View Gene Set 2.296e-05 37 0.0003468 165 Structure and functions of the 20S and 26S proteasomes. www.ncbi.nlm.ni...
PMID 9804427 View Gene Set 2.349e-05 14 0.0003527 167 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. www.ncbi.nlm.ni...
PMID 9891079 View Gene Set 2.575e-05 15 0.0003842 168 Cyclin E associates with BAF155 and BRG1 components of the mammalian SWI-SNF complex and alters the ability of BRG1 to induce growth arrest. www.ncbi.nlm.ni...
PMID 18950845 View Gene Set 2.678e-05 88 0.0003973 169 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. www.ncbi.nlm.ni...
PMID 11742988 View Gene Set 2.785e-05 20 0.0004072 170 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. www.ncbi.nlm.ni...
PMID 15226314 View Gene Set 2.794e-05 20 0.0004072 170 Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. www.ncbi.nlm.ni...
PMID 19019082 View Gene Set 2.771e-05 49 0.0004072 170 Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. www.ncbi.nlm.ni...
PMID 16083285 View Gene Set 3.163e-05 59 0.0004584 173 Global phosphoproteome of HT-29 human colon adenocarcinoma cells. www.ncbi.nlm.ni...
PMID 17577209 View Gene Set 3.202e-05 28 0.0004613 174 The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. www.ncbi.nlm.ni...
PMID 11337588 View Gene Set 3.401e-05 17 0.0004872 175 Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. www.ncbi.nlm.ni...
PMID 18660489 View Gene Set 3.639e-05 250 0.0005184 176 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. www.ncbi.nlm.ni...
PMID 12481031 View Gene Set 4.2e-05 21 0.0005948 177 CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. www.ncbi.nlm.ni...
PMID 12609982 View Gene Set 4.225e-05 11 0.0005951 178 TIP120A associates with cullins and modulates ubiquitin ligase activity. www.ncbi.nlm.ni...
PMID 18782753 View Gene Set 4.347e-05 45 0.0006088 179 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. www.ncbi.nlm.ni...
PMID 19027726 View Gene Set 4.372e-05 73 0.0006089 180 The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. www.ncbi.nlm.ni...
PMID 20226869 View Gene Set 4.44e-05 25 0.000615 181 Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. www.ncbi.nlm.ni...
PMID 11095689 View Gene Set 5.027e-05 17 0.0006925 182 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. www.ncbi.nlm.ni...
PMID 11252894 View Gene Set 5.207e-05 44 0.0007134 183 Three ways to make a vesicle. www.ncbi.nlm.ni...
PMID 12837248 View Gene Set 5.296e-05 22 0.0007202 184 The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. www.ncbi.nlm.ni...
PMID 18826954 View Gene Set 5.315e-05 10 0.0007202 184 SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. www.ncbi.nlm.ni...
PMID 17215244 View Gene Set 5.417e-05 31 0.0007302 186 Purification and identification of G protein-coupled receptor protein complexes under native conditions. www.ncbi.nlm.ni...
PMID 15502821 View Gene Set 5.463e-05 12 0.0007324 187 A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. www.ncbi.nlm.ni...
PMID 16541025 View Gene Set 5.941e-05 19 0.0007881 188 Shugoshin collaborates with protein phosphatase 2A to protect cohesin. www.ncbi.nlm.ni...
PMID 16712791 View Gene Set 5.916e-05 342 0.0007881 188 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. www.ncbi.nlm.ni...
PMID 16387653 View Gene Set 6.586e-05 42 0.000869 190 ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. www.ncbi.nlm.ni...
PMID 11812149 View Gene Set 7.088e-05 13 0.0009304 191 Protein-protein interactions of hCsl4p with other human exosome subunits. www.ncbi.nlm.ni...
PMID 12859895 View Gene Set 7.236e-05 47 0.0009449 192 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. www.ncbi.nlm.ni...
PMID 11535616 View Gene Set 7.327e-05 18 0.0009469 193 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1 BUB3 CDC20 and MAD2. www.ncbi.nlm.ni...
PMID 14593737 View Gene Set 7.327e-05 18 0.0009469 193 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. www.ncbi.nlm.ni...
PMID 17158748 View Gene Set 7.555e-05 13 0.0009714 195 The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity. www.ncbi.nlm.ni...
PMID 12920132 View Gene Set 7.846e-05 13 0.001004 196 The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. www.ncbi.nlm.ni...
PMID 19183483 View Gene Set 8.004e-05 17 0.001019 197 Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. www.ncbi.nlm.ni...
PMID 11102443 View Gene Set 8.167e-05 14 0.001034 198 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. www.ncbi.nlm.ni...
PMID 11799066 View Gene Set 9.032e-05 21 0.001138 199 Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. www.ncbi.nlm.ni...
PMID 11719186 View Gene Set 9.156e-05 17 0.001148 200 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. www.ncbi.nlm.ni...

Gene Set Collection: ChromosomalTiles5Mb

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null chr22_37.5-42.5Mb View Gene Set 1.07e-05 59 0.01192 1 Genomic tile: chr22 ; 37500001-42500001 Mb genome.ucsc.edu...
Null chr1_220-225Mb View Gene Set 7.107e-05 28 0.03959 2 Genomic tile: chr1 ; 220000001-225000001 Mb genome.ucsc.edu...
Null chr22_40-45Mb View Gene Set 0.0001152 51 0.04279 3 Genomic tile: chr22 ; 40000001-45000001 Mb genome.ucsc.edu...

Gene Set Collection: Prosite

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null PS50102 View Gene Set 3.723e-24 229 2.736e-21 1 RRM expasy.org/pros...
Null PS50127 View Gene Set 1.285e-09 41 4.721e-07 2 UBIQUITIN_CONJUGAT_2 expasy.org/pros...
Null PS00183 View Gene Set 6.654e-07 25 0.0001464 3 UBIQUITIN_CONJUGAT_1 expasy.org/pros...
Null PS51192 View Gene Set 7.969e-07 112 0.0001464 3 HELICASE_ATP_BIND_1 expasy.org/pros...
Null PS51194 View Gene Set 1.149e-06 113 0.0001689 5 HELICASE_CTER expasy.org/pros...
Null PS00674 View Gene Set 2.711e-06 29 0.0003321 6 AAA expasy.org/pros...
Null PS00178 View Gene Set 3.293e-06 15 0.0003458 7 AA_TRNA_LIGASE_I expasy.org/pros...
Null PS50082 View Gene Set 4.583e-06 233 0.0003743 8 WD_REPEATS_2 expasy.org/pros...
Null PS51195 View Gene Set 4.114e-06 37 0.0003743 8 Q_MOTIF expasy.org/pros...
Null PS51352 View Gene Set 5.355e-06 36 0.0003936 10 THIOREDOXIN_2 expasy.org/pros...
Null PS50294 View Gene Set 8.775e-06 245 0.0005864 11 WD_REPEATS_REGION expasy.org/pros...
Null PS00194 View Gene Set 1.603e-05 17 0.0009819 12 THIOREDOXIN_1 expasy.org/pros...
Null PS50166 View Gene Set 2.789e-05 13 0.001577 13 IMPORTIN_B_NT expasy.org/pros...
Null PS00039 View Gene Set 3.71e-05 27 0.001948 14 DEAD_ATP_HELICASE expasy.org/pros...
Null PS00678 View Gene Set 4.374e-05 168 0.002143 15 WD_REPEATS_1 expasy.org/pros...
Null PS00750 View Gene Set 9.371e-05 9 0.003827 16 TCP1_1 expasy.org/pros...
Null PS00751 View Gene Set 9.371e-05 9 0.003827 16 TCP1_2 expasy.org/pros...
Null PS00995 View Gene Set 9.371e-05 9 0.003827 16 TCP1_3 expasy.org/pros...
Null PS00847 View Gene Set 0.0001024 6 0.003959 19 MCM_1 expasy.org/pros...
Null PS50051 View Gene Set 0.0001581 8 0.00581 20 MCM_2 expasy.org/pros...
Null PS50293 View Gene Set 0.0001677 134 0.00587 21 TPR_REGION expasy.org/pros...
Null PS00125 View Gene Set 0.0002028 13 0.006776 22 SER_THR_PHOSPHATASE expasy.org/pros...
Null PS00299 View Gene Set 0.0002679 10 0.008561 23 UBIQUITIN_1 expasy.org/pros...
Null PS00301 View Gene Set 0.0004528 11 0.01331 24 EFACTOR_GTP expasy.org/pros...
Null PS50005 View Gene Set 0.0004431 114 0.01331 24 TPR expasy.org/pros...
Null PS50072 View Gene Set 0.0006191 35 0.0175 26 CSA_PPIASE_2 expasy.org/pros...
Null PS50866 View Gene Set 0.0006772 19 0.01844 27 GOLD expasy.org/pros...
Null PS00170 View Gene Set 0.0007609 25 0.01929 28 CSA_PPIASE_1 expasy.org/pros...
Null PS50934 View Gene Set 0.0007498 6 0.01929 28 SWIRM expasy.org/pros...
Null PS00598 View Gene Set 0.0008054 21 0.01973 30 CHROMO_1 expasy.org/pros...
Null PS50053 View Gene Set 0.0008618 58 0.02043 31 UBIQUITIN_2 expasy.org/pros...
Null PS50076 View Gene Set 0.0009568 51 0.02198 32 DNAJ_2 expasy.org/pros...
Null PS50908 View Gene Set 0.001049 10 0.02336 33 RWD expasy.org/pros...
Null PS50800 View Gene Set 0.001249 23 0.027 34 SAP expasy.org/pros...
Null PS00292 View Gene Set 0.001309 10 0.02748 35 CYCLINS expasy.org/pros...
Null PS50137 View Gene Set 0.001357 20 0.0277 36 DS_RBD expasy.org/pros...
Null PS01036 View Gene Set 0.001423 14 0.02828 37 HSP70_3 expasy.org/pros...
Null PS51309 View Gene Set 0.001465 7 0.02834 38 PABC expasy.org/pros...
Null PS51391 View Gene Set 0.00161 8 0.03033 39 CID expasy.org/pros...
Null PS50171 View Gene Set 0.001662 9 0.03054 40 ZF_MATRIN expasy.org/pros...
Null PS51419 View Gene Set 0.001768 83 0.03169 41 RAB expasy.org/pros...
Null PS01358 View Gene Set 0.002097 25 0.03585 42 ZF_RANBP2_1 expasy.org/pros...
Null PS50199 View Gene Set 0.002097 23 0.03585 42 ZF_RANBP2_2 expasy.org/pros...
Null PS50237 View Gene Set 0.002331 29 0.03893 44 HECT expasy.org/pros...
Null PS51286 View Gene Set 0.002439 6 0.03983 45 RAP expasy.org/pros...
Null PS50890 View Gene Set 0.00266 5 0.0425 46 PUA expasy.org/pros...
Null PS51151 View Gene Set 0.002959 9 0.04628 47 NAC_AB expasy.org/pros...
Null PS50862 View Gene Set 0.003038 18 0.04652 48 AA_TRNA_LIGASE_II expasy.org/pros...
Null PS50077 View Gene Set 0.003395 21 0.04871 49 HEAT_REPEAT expasy.org/pros...
Null PS50103 View Gene Set 0.003294 60 0.04871 49 ZF_C3H1 expasy.org/pros...
Null PS50969 View Gene Set 0.003446 8 0.04871 49 FCP1 expasy.org/pros...
Null PS51273 View Gene Set 0.003425 6 0.04871 49 GATASE_TYPE_1 expasy.org/pros...

Gene Set Collection: Enzyme

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null EC:6.3.2.19 View Gene Set 1.412e-12 79 2.232e-10 1 Ubiquitin--protein ligase expasy.org/enzy...
Null EC:1.6.99.3 View Gene Set 1.183e-06 35 9.346e-05 2 NADH dehydrogenase expasy.org/enzy...
Null EC:1.6.5.3 View Gene Set 2.529e-06 43 0.0001332 3 NADH dehydrogenase (ubiquinone) expasy.org/enzy...
Null EC:2.7.11.1 View Gene Set 6.301e-05 91 0.002489 4 Non-specific serine/threonine protein kinase expasy.org/enzy...
Null EC:1.10.2.2 View Gene Set 0.0001413 13 0.004464 5 Ubiquinol--cytochrome-c reductase expasy.org/enzy...
Null EC:2.1.1.43 View Gene Set 0.0006527 19 0.01559 6 Histone-lysine N-methyltransferase expasy.org/enzy...
Null EC:3.6.3.14 View Gene Set 0.0006906 45 0.01559 6 H(+)-transporting two-sector ATPase expasy.org/enzy...
Null EC:4.2.99.18 View Gene Set 0.001108 6 0.02188 8 DNA-(apurinic or apyrimidinic site) lyase expasy.org/enzy...
Null EC:5.3.4.1 View Gene Set 0.001589 4 0.02789 9 Protein disulfide-isomerase expasy.org/enzy...
Null EC:3.6.4.13 View Gene Set 0.001831 13 0.02893 10 RNA helicase expasy.org/enzy...

Gene Set Collection: ppi.BIND

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.E2F4 View Gene Set 2.896e-05 14 0.005473 1 Protein-protein-interaction for E2F4 www.ncbi.nlm.ni...
Null ppi.1491938 View Gene Set 6.716e-05 25 0.006039 2 Protein-protein-interaction for 1491938 www.ncbi.nlm.ni...
Null ppi.E2F1 View Gene Set 0.0001426 12 0.006039 2 Protein-protein-interaction for E2F1 www.ncbi.nlm.ni...
Null ppi.ARHGAP8 View Gene Set 0.0001433 8 0.006039 2 Protein-protein-interaction for ARHGAP8 www.ncbi.nlm.ni...
Null ppi.RBL2 View Gene Set 0.0001598 14 0.006039 2 Protein-protein-interaction for RBL2 www.ncbi.nlm.ni...
Null ppi.CDKN1A View Gene Set 0.0002771 9 0.00873 6 Protein-protein-interaction for CDKN1A www.ncbi.nlm.ni...
Null ppi.RIBIN View Gene Set 0.0003477 8 0.009388 7 Protein-protein-interaction for RIBIN www.ncbi.nlm.ni...
Null ppi.UXT View Gene Set 0.0004684 8 0.01107 8 Protein-protein-interaction for UXT www.ncbi.nlm.ni...
Null ppi.155871 View Gene Set 0.0005555 21 0.01136 9 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.SNORD3A View Gene Set 0.000601 9 0.01136 9 Protein-protein-interaction for SNORD3A www.ncbi.nlm.ni...
Null ppi.PRNP View Gene Set 0.001326 7 0.02278 11 Protein-protein-interaction for PRNP www.ncbi.nlm.ni...
Null ppi.RNF11 View Gene Set 0.001836 8 0.0267 12 Protein-protein-interaction for RNF11 www.ncbi.nlm.ni...
Null ppi.GEMIN6 View Gene Set 0.001711 7 0.0267 12 Protein-protein-interaction for GEMIN6 www.ncbi.nlm.ni...
Null ppi.RALBP1 View Gene Set 0.002331 7 0.03082 14 Protein-protein-interaction for RALBP1 www.ncbi.nlm.ni...
Null ppi.COPS4 View Gene Set 0.002578 7 0.03082 14 Protein-protein-interaction for COPS4 www.ncbi.nlm.ni...
Null ppi.951475 View Gene Set 0.002609 43 0.03082 14 Protein-protein-interaction for 951475 www.ncbi.nlm.ni...
Null ppi.RB1 View Gene Set 0.003188 44 0.03544 17 Protein-protein-interaction for RB1 www.ncbi.nlm.ni...
Null ppi.NCF1C View Gene Set 0.003607 7 0.03788 18 Protein-protein-interaction for NCF1C www.ncbi.nlm.ni...
Null ppi.MSH2 View Gene Set 0.004576 7 0.04326 19 Protein-protein-interaction for MSH2 www.ncbi.nlm.ni...
Null ppi.PAK1 View Gene Set 0.004578 7 0.04326 19 Protein-protein-interaction for PAK1 www.ncbi.nlm.ni...
Null ppi.PEX19 View Gene Set 0.005399 7 0.04859 21 Protein-protein-interaction for PEX19 www.ncbi.nlm.ni...
Null ppi.BACE1 View Gene Set 0.005717 7 0.04912 22 Protein-protein-interaction for BACE1 www.ncbi.nlm.ni...

Gene Set Collection: ppi.BioGRID

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.155871 View Gene Set 6.661e-40 236 1.53e-36 1 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.MEPCE View Gene Set 1.472e-31 147 1.691e-28 2 Protein-protein-interaction for MEPCE www.ncbi.nlm.ni...
Null ppi.SRRM2 View Gene Set 1.091e-19 101 8.353e-17 3 Protein-protein-interaction for SRRM2 www.ncbi.nlm.ni...
Null ppi.KHDRBS2 View Gene Set 8.523e-14 46 4.894e-11 4 Protein-protein-interaction for KHDRBS2 www.ncbi.nlm.ni...
Null ppi.72462 View Gene Set 2.487e-13 42 1.143e-10 5 Protein-protein-interaction for 72462 www.ncbi.nlm.ni...
Null ppi.SRRM1 View Gene Set 4.237e-13 64 1.39e-10 6 Protein-protein-interaction for SRRM1 www.ncbi.nlm.ni...
Null ppi.RUVBL2 View Gene Set 3.838e-13 64 1.39e-10 6 Protein-protein-interaction for RUVBL2 www.ncbi.nlm.ni...
Null ppi.TP53 View Gene Set 7.113e-13 168 2.042e-10 8 Protein-protein-interaction for TP53 www.ncbi.nlm.ni...
Null ppi.RNPS1 View Gene Set 6.36e-10 38 1.623e-07 9 Protein-protein-interaction for RNPS1 www.ncbi.nlm.ni...
Null ppi.WBP4 View Gene Set 1.132e-09 35 2.6e-07 10 Protein-protein-interaction for WBP4 www.ncbi.nlm.ni...
Null ppi.GSTK1 View Gene Set 2.411e-09 26 5.036e-07 11 Protein-protein-interaction for GSTK1 www.ncbi.nlm.ni...
Null ppi.EIF3F View Gene Set 4.52e-09 22 8.651e-07 12 Protein-protein-interaction for EIF3F www.ncbi.nlm.ni...
Null ppi.TOPORS View Gene Set 6.174e-09 27 1.013e-06 13 Protein-protein-interaction for TOPORS www.ncbi.nlm.ni...
Null ppi.SUMO2 View Gene Set 6.096e-09 50 1.013e-06 13 Protein-protein-interaction for SUMO2 www.ncbi.nlm.ni...
Null ppi.WDR48 View Gene Set 2.161e-08 52 3.232e-06 15 Protein-protein-interaction for WDR48 www.ncbi.nlm.ni...
Null ppi.HIST1H4A View Gene Set 2.252e-08 28 3.232e-06 15 Protein-protein-interaction for HIST1H4A www.ncbi.nlm.ni...
Null ppi.CDT1 View Gene Set 2.782e-08 37 3.758e-06 17 Protein-protein-interaction for CDT1 www.ncbi.nlm.ni...
Null ppi.GPN1 View Gene Set 2.947e-08 27 3.76e-06 18 Protein-protein-interaction for GPN1 www.ncbi.nlm.ni...
Null ppi.EIF1B View Gene Set 4e-08 25 4.593e-06 19 Protein-protein-interaction for EIF1B www.ncbi.nlm.ni...
Null ppi.RRP1B View Gene Set 3.928e-08 21 4.593e-06 19 Protein-protein-interaction for RRP1B www.ncbi.nlm.ni...
Null ppi.STRN3 View Gene Set 4.926e-08 22 5.388e-06 21 Protein-protein-interaction for STRN3 www.ncbi.nlm.ni...
Null ppi.TH1L View Gene Set 7.273e-08 26 7.594e-06 22 Protein-protein-interaction for TH1L www.ncbi.nlm.ni...
Null ppi.KIAA1377 View Gene Set 7.921e-08 57 7.91e-06 23 Protein-protein-interaction for KIAA1377 www.ncbi.nlm.ni...
Null ppi.TCERG1 View Gene Set 9.527e-08 35 8.417e-06 24 Protein-protein-interaction for TCERG1 www.ncbi.nlm.ni...
Null ppi.UIMC1 View Gene Set 9.012e-08 30 8.417e-06 24 Protein-protein-interaction for UIMC1 www.ncbi.nlm.ni...
Null ppi.DDX56 View Gene Set 9.212e-08 20 8.417e-06 24 Protein-protein-interaction for DDX56 www.ncbi.nlm.ni...
Null ppi.DDX20 View Gene Set 1.017e-07 17 8.649e-06 27 Protein-protein-interaction for DDX20 www.ncbi.nlm.ni...
Null ppi.PRPF40A View Gene Set 1.268e-07 53 1.04e-05 28 Protein-protein-interaction for PRPF40A www.ncbi.nlm.ni...
Null ppi.COPS6 View Gene Set 1.634e-07 65 1.225e-05 29 Protein-protein-interaction for COPS6 www.ncbi.nlm.ni...
Null ppi.LYAR View Gene Set 1.554e-07 26 1.225e-05 29 Protein-protein-interaction for LYAR www.ncbi.nlm.ni...
Null ppi.CNBP View Gene Set 1.653e-07 17 1.225e-05 29 Protein-protein-interaction for CNBP www.ncbi.nlm.ni...
Null ppi.DDA1 View Gene Set 2.289e-07 44 1.643e-05 32 Protein-protein-interaction for DDA1 www.ncbi.nlm.ni...
Null ppi.UCHL5 View Gene Set 2.396e-07 33 1.668e-05 33 Protein-protein-interaction for UCHL5 www.ncbi.nlm.ni...
Null ppi.CBX5 View Gene Set 2.707e-07 38 1.828e-05 34 Protein-protein-interaction for CBX5 www.ncbi.nlm.ni...
Null ppi.PINX1 View Gene Set 3.15e-07 19 2.067e-05 35 Protein-protein-interaction for PINX1 www.ncbi.nlm.ni...
Null ppi.MTA2 View Gene Set 3.458e-07 25 2.206e-05 36 Protein-protein-interaction for MTA2 www.ncbi.nlm.ni...
Null ppi.CHFR View Gene Set 6.015e-07 18 3.734e-05 37 Protein-protein-interaction for CHFR www.ncbi.nlm.ni...
Null ppi.PABPC1 View Gene Set 7.836e-07 26 4.737e-05 38 Protein-protein-interaction for PABPC1 www.ncbi.nlm.ni...
Null ppi.MYC View Gene Set 9.862e-07 42 5.809e-05 39 Protein-protein-interaction for MYC www.ncbi.nlm.ni...
Null ppi.ORC2L View Gene Set 1.353e-06 12 7.769e-05 40 Protein-protein-interaction for ORC2L www.ncbi.nlm.ni...
Null ppi.BRCC3 View Gene Set 1.729e-06 22 9.687e-05 41 Protein-protein-interaction for BRCC3 www.ncbi.nlm.ni...
Null ppi.EIF3A View Gene Set 1.851e-06 12 0.0001012 42 Protein-protein-interaction for EIF3A www.ncbi.nlm.ni...
Null ppi.BANF1 View Gene Set 2.084e-06 34 0.0001113 43 Protein-protein-interaction for BANF1 www.ncbi.nlm.ni...
Null ppi.SIN3A View Gene Set 2.203e-06 104 0.000115 44 Protein-protein-interaction for SIN3A www.ncbi.nlm.ni...
Null ppi.RUVBL1 View Gene Set 2.377e-06 38 0.0001187 45 Protein-protein-interaction for RUVBL1 www.ncbi.nlm.ni...
Null ppi.H2AFY View Gene Set 2.352e-06 12 0.0001187 45 Protein-protein-interaction for H2AFY www.ncbi.nlm.ni...
Null ppi.ZMYM2 View Gene Set 2.539e-06 14 0.0001226 47 Protein-protein-interaction for ZMYM2 www.ncbi.nlm.ni...
Null ppi.DZIP3 View Gene Set 2.562e-06 18 0.0001226 47 Protein-protein-interaction for DZIP3 www.ncbi.nlm.ni...
Null ppi.MBD2 View Gene Set 2.643e-06 11 0.0001239 49 Protein-protein-interaction for MBD2 www.ncbi.nlm.ni...
Null ppi.PUF60 View Gene Set 3.598e-06 31 0.0001653 50 Protein-protein-interaction for PUF60 www.ncbi.nlm.ni...
Null ppi.UBA5 View Gene Set 4.078e-06 35 0.0001837 51 Protein-protein-interaction for UBA5 www.ncbi.nlm.ni...
Null ppi.EIF3B View Gene Set 4.302e-06 10 0.00019 52 Protein-protein-interaction for EIF3B www.ncbi.nlm.ni...
Null ppi.C14orf1 View Gene Set 4.861e-06 38 0.0002107 53 Protein-protein-interaction for C14orf1 www.ncbi.nlm.ni...
Null ppi.MGMT View Gene Set 5.258e-06 28 0.0002237 54 Protein-protein-interaction for MGMT www.ncbi.nlm.ni...
Null ppi.TRIM39 View Gene Set 5.625e-06 15 0.0002346 55 Protein-protein-interaction for TRIM39 www.ncbi.nlm.ni...
Null ppi.RBX1 View Gene Set 5.719e-06 30 0.0002346 55 Protein-protein-interaction for RBX1 www.ncbi.nlm.ni...
Null ppi.SF3A2 View Gene Set 7.237e-06 16 0.0002917 57 Protein-protein-interaction for SF3A2 www.ncbi.nlm.ni...
Null ppi.CDK2 View Gene Set 8.906e-06 12 0.0003527 58 Protein-protein-interaction for CDK2 www.ncbi.nlm.ni...
Null ppi.IMMT View Gene Set 9.259e-06 15 0.0003605 59 Protein-protein-interaction for IMMT www.ncbi.nlm.ni...
Null ppi.WDR8 View Gene Set 1.008e-05 23 0.0003857 60 Protein-protein-interaction for WDR8 www.ncbi.nlm.ni...
Null ppi.MKRN3 View Gene Set 1.043e-05 14 0.0003927 61 Protein-protein-interaction for MKRN3 www.ncbi.nlm.ni...
Null ppi.HIST2H2BE View Gene Set 1.082e-05 17 0.0004009 62 Protein-protein-interaction for HIST2H2BE www.ncbi.nlm.ni...
Null ppi.SF3B1 View Gene Set 1.353e-05 24 0.0004935 63 Protein-protein-interaction for SF3B1 www.ncbi.nlm.ni...
Null ppi.CARM1 View Gene Set 1.435e-05 32 0.0004936 64 Protein-protein-interaction for CARM1 www.ncbi.nlm.ni...
Null ppi.RPAP1 View Gene Set 1.435e-05 24 0.0004936 64 Protein-protein-interaction for RPAP1 www.ncbi.nlm.ni...
Null ppi.AKTIP View Gene Set 1.413e-05 21 0.0004936 64 Protein-protein-interaction for AKTIP www.ncbi.nlm.ni...
Null ppi.RPAP2 View Gene Set 1.461e-05 43 0.0004936 64 Protein-protein-interaction for RPAP2 www.ncbi.nlm.ni...
Null ppi.BAZ1B View Gene Set 1.461e-05 30 0.0004936 64 Protein-protein-interaction for BAZ1B www.ncbi.nlm.ni...
Null ppi.C19orf62 View Gene Set 1.508e-05 29 0.0004964 69 Protein-protein-interaction for C19orf62 www.ncbi.nlm.ni...
Null ppi.RB1 View Gene Set 1.534e-05 46 0.0004964 69 Protein-protein-interaction for RB1 www.ncbi.nlm.ni...
Null ppi.RNF185 View Gene Set 1.532e-05 13 0.0004964 69 Protein-protein-interaction for RNF185 www.ncbi.nlm.ni...
Null ppi.RNF111 View Gene Set 1.564e-05 20 0.0004989 72 Protein-protein-interaction for RNF111 www.ncbi.nlm.ni...
Null ppi.GSK3B View Gene Set 1.749e-05 11 0.0005356 73 Protein-protein-interaction for GSK3B www.ncbi.nlm.ni...
Null ppi.HNRNPL View Gene Set 1.703e-05 8 0.0005356 73 Protein-protein-interaction for HNRNPL www.ncbi.nlm.ni...
Null ppi.C20orf24 View Gene Set 1.733e-05 20 0.0005356 73 Protein-protein-interaction for C20orf24 www.ncbi.nlm.ni...
Null ppi.ORC1L View Gene Set 1.838e-05 9 0.0005555 76 Protein-protein-interaction for ORC1L www.ncbi.nlm.ni...
Null ppi.EXOSC6 View Gene Set 1.932e-05 13 0.0005763 77 Protein-protein-interaction for EXOSC6 www.ncbi.nlm.ni...
Null ppi.RPA2 View Gene Set 2.067e-05 24 0.0006011 78 Protein-protein-interaction for RPA2 www.ncbi.nlm.ni...
Null ppi.TRIM5 View Gene Set 2.062e-05 14 0.0006011 78 Protein-protein-interaction for TRIM5 www.ncbi.nlm.ni...
Null ppi.SAP25 View Gene Set 2.136e-05 29 0.0006133 80 Protein-protein-interaction for SAP25 www.ncbi.nlm.ni...
Null ppi.HNRNPR View Gene Set 2.364e-05 9 0.0006622 81 Protein-protein-interaction for HNRNPR www.ncbi.nlm.ni...
Null ppi.SUPT16H View Gene Set 2.363e-05 11 0.0006622 81 Protein-protein-interaction for SUPT16H www.ncbi.nlm.ni...
Null ppi.USP45 View Gene Set 2.393e-05 21 0.0006622 83 Protein-protein-interaction for USP45 www.ncbi.nlm.ni...
Null ppi.DTX3L View Gene Set 2.507e-05 16 0.0006857 84 Protein-protein-interaction for DTX3L www.ncbi.nlm.ni...
Null ppi.DDX24 View Gene Set 2.606e-05 20 0.0007043 85 Protein-protein-interaction for DDX24 www.ncbi.nlm.ni...
Null ppi.BAT2 View Gene Set 2.642e-05 13 0.0007053 86 Protein-protein-interaction for BAT2 www.ncbi.nlm.ni...
Null ppi.PAAF1 View Gene Set 2.733e-05 20 0.0007053 86 Protein-protein-interaction for PAAF1 www.ncbi.nlm.ni...
Null ppi.HDAC3 View Gene Set 2.687e-05 92 0.0007053 86 Protein-protein-interaction for HDAC3 www.ncbi.nlm.ni...
Null ppi.KEAP1 View Gene Set 2.733e-05 21 0.0007053 86 Protein-protein-interaction for KEAP1 www.ncbi.nlm.ni...
Null ppi.GORASP2 View Gene Set 2.849e-05 17 0.0007271 90 Protein-protein-interaction for GORASP2 www.ncbi.nlm.ni...
Null ppi.SRPK2 View Gene Set 2.973e-05 7 0.0007505 91 Protein-protein-interaction for SRPK2 www.ncbi.nlm.ni...
Null ppi.PDCD4 View Gene Set 3.016e-05 10 0.0007531 92 Protein-protein-interaction for PDCD4 www.ncbi.nlm.ni...
Null ppi.UBE2I View Gene Set 3.069e-05 62 0.0007581 93 Protein-protein-interaction for UBE2I www.ncbi.nlm.ni...
Null ppi.NEK6 View Gene Set 3.266e-05 10 0.0007898 94 Protein-protein-interaction for NEK6 www.ncbi.nlm.ni...
Null ppi.CCNA1 View Gene Set 3.248e-05 22 0.0007898 94 Protein-protein-interaction for CCNA1 www.ncbi.nlm.ni...
Null ppi.ARFIP2 View Gene Set 3.4e-05 9 0.0008136 96 Protein-protein-interaction for ARFIP2 www.ncbi.nlm.ni...
Null ppi.RBL2 View Gene Set 3.549e-05 19 0.0008381 97 Protein-protein-interaction for RBL2 www.ncbi.nlm.ni...
Null ppi.TAF6 View Gene Set 3.576e-05 19 0.0008381 97 Protein-protein-interaction for TAF6 www.ncbi.nlm.ni...
Null ppi.MOBKL3 View Gene Set 3.627e-05 34 0.000839 99 Protein-protein-interaction for MOBKL3 www.ncbi.nlm.ni...
Null ppi.MCM7 View Gene Set 3.689e-05 11 0.000839 99 Protein-protein-interaction for MCM7 www.ncbi.nlm.ni...
Null ppi.BRF2 View Gene Set 3.683e-05 23 0.000839 99 Protein-protein-interaction for BRF2 www.ncbi.nlm.ni...
Null ppi.OTUB1 View Gene Set 3.746e-05 18 0.0008436 102 Protein-protein-interaction for OTUB1 www.ncbi.nlm.ni...
Null ppi.USP14 View Gene Set 3.802e-05 22 0.0008479 103 Protein-protein-interaction for USP14 www.ncbi.nlm.ni...
Null ppi.LUC7L2 View Gene Set 4.089e-05 26 0.0008906 104 Protein-protein-interaction for LUC7L2 www.ncbi.nlm.ni...
Null ppi.USF1 View Gene Set 4.11e-05 14 0.0008906 104 Protein-protein-interaction for USF1 www.ncbi.nlm.ni...
Null ppi.MCPH1 View Gene Set 4.081e-05 17 0.0008906 104 Protein-protein-interaction for MCPH1 www.ncbi.nlm.ni...
Null ppi.NUDT18 View Gene Set 4.15e-05 26 0.0008908 107 Protein-protein-interaction for NUDT18 www.ncbi.nlm.ni...
Null ppi.CHD1L View Gene Set 4.204e-05 15 0.0008942 108 Protein-protein-interaction for CHD1L www.ncbi.nlm.ni...
Null ppi.BRE View Gene Set 4.333e-05 16 0.000913 109 Protein-protein-interaction for BRE www.ncbi.nlm.ni...
Null ppi.NPM1 View Gene Set 4.453e-05 16 0.0009298 110 Protein-protein-interaction for NPM1 www.ncbi.nlm.ni...
Null ppi.C12orf44 View Gene Set 4.978e-05 32 0.001021 111 Protein-protein-interaction for C12orf44 www.ncbi.nlm.ni...
Null ppi.USP42 View Gene Set 4.972e-05 24 0.001021 111 Protein-protein-interaction for USP42 www.ncbi.nlm.ni...
Null ppi.EIF3H View Gene Set 5.044e-05 16 0.001025 113 Protein-protein-interaction for EIF3H www.ncbi.nlm.ni...
Null ppi.CYCS View Gene Set 5.096e-05 10 0.001027 114 Protein-protein-interaction for CYCS www.ncbi.nlm.ni...
Null ppi.PA2G4 View Gene Set 5.193e-05 7 0.001037 115 Protein-protein-interaction for PA2G4 www.ncbi.nlm.ni...
Null ppi.RNF130 View Gene Set 5.366e-05 9 0.001062 116 Protein-protein-interaction for RNF130 www.ncbi.nlm.ni...
Null ppi.GIYD2 View Gene Set 5.971e-05 32 0.001172 117 Protein-protein-interaction for GIYD2 www.ncbi.nlm.ni...
Null ppi.TOB1 View Gene Set 6.244e-05 14 0.0012 118 Protein-protein-interaction for TOB1 www.ncbi.nlm.ni...
Null ppi.RNF11 View Gene Set 6.18e-05 16 0.0012 118 Protein-protein-interaction for RNF11 www.ncbi.nlm.ni...
Null ppi.BCL7C View Gene Set 6.268e-05 11 0.0012 118 Protein-protein-interaction for BCL7C www.ncbi.nlm.ni...
Null ppi.GAR1 View Gene Set 6.432e-05 9 0.00122 121 Protein-protein-interaction for GAR1 www.ncbi.nlm.ni...
Null ppi.SSRP1 View Gene Set 6.481e-05 15 0.00122 121 Protein-protein-interaction for SSRP1 www.ncbi.nlm.ni...
Null ppi.RBL1 View Gene Set 6.628e-05 24 0.001238 123 Protein-protein-interaction for RBL1 www.ncbi.nlm.ni...
Null ppi.USP36 View Gene Set 6.834e-05 17 0.001258 124 Protein-protein-interaction for USP36 www.ncbi.nlm.ni...
Null ppi.CADPS2 View Gene Set 6.844e-05 9 0.001258 124 Protein-protein-interaction for CADPS2 www.ncbi.nlm.ni...
Null ppi.TMBIM4 View Gene Set 7.405e-05 9 0.00135 126 Protein-protein-interaction for TMBIM4 www.ncbi.nlm.ni...
Null ppi.RCOR1 View Gene Set 8.008e-05 21 0.001448 127 Protein-protein-interaction for RCOR1 www.ncbi.nlm.ni...
Null ppi.RPA1 View Gene Set 8.931e-05 23 0.001603 128 Protein-protein-interaction for RPA1 www.ncbi.nlm.ni...
Null ppi.CCDC106 View Gene Set 9.366e-05 10 0.001655 129 Protein-protein-interaction for CCDC106 www.ncbi.nlm.ni...
Null ppi.KAT2B View Gene Set 9.363e-05 71 0.001655 129 Protein-protein-interaction for KAT2B www.ncbi.nlm.ni...
Null ppi.SAE1 View Gene Set 9.471e-05 10 0.001661 131 Protein-protein-interaction for SAE1 www.ncbi.nlm.ni...
Null ppi.MYSM1 View Gene Set 9.671e-05 13 0.001683 132 Protein-protein-interaction for MYSM1 www.ncbi.nlm.ni...
Null ppi.RFWD2 View Gene Set 9.831e-05 26 0.001685 133 Protein-protein-interaction for RFWD2 www.ncbi.nlm.ni...
Null ppi.PSMD6 View Gene Set 9.776e-05 21 0.001685 133 Protein-protein-interaction for PSMD6 www.ncbi.nlm.ni...
Null ppi.ASCC2 View Gene Set 0.0001019 36 0.001733 135 Protein-protein-interaction for ASCC2 www.ncbi.nlm.ni...
Null ppi.ALL1 View Gene Set 0.0001039 19 0.001755 136 Protein-protein-interaction for ALL1 www.ncbi.nlm.ni...
Null ppi.FOXM1 View Gene Set 0.0001047 8 0.001756 137 Protein-protein-interaction for FOXM1 www.ncbi.nlm.ni...
Null ppi.PRMT1 View Gene Set 0.0001064 15 0.001772 138 Protein-protein-interaction for PRMT1 www.ncbi.nlm.ni...
Null ppi.EXOSC4 View Gene Set 0.000111 9 0.001821 139 Protein-protein-interaction for EXOSC4 www.ncbi.nlm.ni...
Null ppi.DPY30 View Gene Set 0.0001104 9 0.001821 139 Protein-protein-interaction for DPY30 www.ncbi.nlm.ni...
Null ppi.RNF166 View Gene Set 0.000113 11 0.00184 141 Protein-protein-interaction for RNF166 www.ncbi.nlm.ni...
Null ppi.TSC2 View Gene Set 0.0001198 21 0.001924 142 Protein-protein-interaction for TSC2 www.ncbi.nlm.ni...
Null ppi.ZNRF1 View Gene Set 0.0001195 12 0.001924 142 Protein-protein-interaction for ZNRF1 www.ncbi.nlm.ni...
Null ppi.CAND1 View Gene Set 0.0001207 11 0.001926 144 Protein-protein-interaction for CAND1 www.ncbi.nlm.ni...
Null ppi.HIST1H3A View Gene Set 0.0001237 30 0.00196 145 Protein-protein-interaction for HIST1H3A www.ncbi.nlm.ni...
Null ppi.FHOD1 View Gene Set 0.0001285 11 0.001992 146 Protein-protein-interaction for FHOD1 www.ncbi.nlm.ni...
Null ppi.TAF1D View Gene Set 0.0001289 21 0.001992 146 Protein-protein-interaction for TAF1D www.ncbi.nlm.ni...
Null ppi.MBD3L1 View Gene Set 0.0001274 11 0.001992 146 Protein-protein-interaction for MBD3L1 www.ncbi.nlm.ni...
Null ppi.IKBKE View Gene Set 0.0001292 19 0.001992 146 Protein-protein-interaction for IKBKE www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 0.0001329 40 0.002035 150 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.ASF1B View Gene Set 0.0001399 23 0.002129 151 Protein-protein-interaction for ASF1B www.ncbi.nlm.ni...
Null ppi.NEDD4 View Gene Set 0.0001422 18 0.002144 152 Protein-protein-interaction for NEDD4 www.ncbi.nlm.ni...
Null ppi.DCUN1D1 View Gene Set 0.0001428 8 0.002144 152 Protein-protein-interaction for DCUN1D1 www.ncbi.nlm.ni...
Null ppi.FBXW11 View Gene Set 0.0001514 25 0.002259 154 Protein-protein-interaction for FBXW11 www.ncbi.nlm.ni...
Null ppi.DCAF4 View Gene Set 0.0001527 7 0.002263 155 Protein-protein-interaction for DCAF4 www.ncbi.nlm.ni...
Null ppi.UBA2 View Gene Set 0.0001578 9 0.002282 156 Protein-protein-interaction for UBA2 www.ncbi.nlm.ni...
Null ppi.USP43 View Gene Set 0.000159 9 0.002282 156 Protein-protein-interaction for USP43 www.ncbi.nlm.ni...
Null ppi.POLR3H View Gene Set 0.0001582 14 0.002282 156 Protein-protein-interaction for POLR3H www.ncbi.nlm.ni...
Null ppi.THRB View Gene Set 0.0001579 8 0.002282 156 Protein-protein-interaction for THRB www.ncbi.nlm.ni...
Null ppi.CDC45 View Gene Set 0.0001565 9 0.002282 156 Protein-protein-interaction for CDC45 www.ncbi.nlm.ni...
Null ppi.VHL View Gene Set 0.0001615 50 0.002304 161 Protein-protein-interaction for VHL www.ncbi.nlm.ni...
Null ppi.PSMD14 View Gene Set 0.000171 16 0.002425 162 Protein-protein-interaction for PSMD14 www.ncbi.nlm.ni...
Null ppi.CDKN1A View Gene Set 0.0001729 14 0.002427 163 Protein-protein-interaction for CDKN1A www.ncbi.nlm.ni...
Null ppi.SMNDC1 View Gene Set 0.0001733 8 0.002427 163 Protein-protein-interaction for SMNDC1 www.ncbi.nlm.ni...
Null ppi.GCN1L1 View Gene Set 0.0001878 15 0.002615 165 Protein-protein-interaction for GCN1L1 www.ncbi.nlm.ni...
Null ppi.ZEB2 View Gene Set 0.000195 8 0.002698 166 Protein-protein-interaction for ZEB2 www.ncbi.nlm.ni...
Null ppi.PTP4A3 View Gene Set 0.0002124 18 0.002904 167 Protein-protein-interaction for PTP4A3 www.ncbi.nlm.ni...
Null ppi.C1orf103 View Gene Set 0.0002115 95 0.002904 167 Protein-protein-interaction for C1orf103 www.ncbi.nlm.ni...
Null ppi.LSM2 View Gene Set 0.0002146 19 0.002916 169 Protein-protein-interaction for LSM2 www.ncbi.nlm.ni...
Null ppi.USP7 View Gene Set 0.0002239 24 0.003025 170 Protein-protein-interaction for USP7 www.ncbi.nlm.ni...
Null ppi.KIAA1967 View Gene Set 0.000232 17 0.003116 171 Protein-protein-interaction for KIAA1967 www.ncbi.nlm.ni...
Null ppi.WWOX View Gene Set 0.0002347 19 0.003134 172 Protein-protein-interaction for WWOX www.ncbi.nlm.ni...
Null ppi.MBD3L2 View Gene Set 0.0002384 11 0.003151 173 Protein-protein-interaction for MBD3L2 www.ncbi.nlm.ni...
Null ppi.CDCA8 View Gene Set 0.0002387 8 0.003151 173 Protein-protein-interaction for CDCA8 www.ncbi.nlm.ni...
Null ppi.HAP1 View Gene Set 0.0002476 23 0.00325 175 Protein-protein-interaction for HAP1 www.ncbi.nlm.ni...
Null ppi.RNU12-2P View Gene Set 0.0002584 18 0.003316 176 Protein-protein-interaction for RNU12-2P www.ncbi.nlm.ni...
Null ppi.RNU11 View Gene Set 0.0002584 18 0.003316 176 Protein-protein-interaction for RNU11 www.ncbi.nlm.ni...
Null ppi.SP1 View Gene Set 0.0002576 79 0.003316 176