MOLECULAR EFFECTS OF GENISTEIN ON THE URETHRA
Ashley E. Ross, Luigi Marchionni, Timothy M. Philips, Rebecca M. Miller, Paula J. Hurley, Brian W. Simons, Amirali H. Salmasi, Anthony J. Schaeffer, John P. Gearhart, Edward M. Schaeffer
The "Supplementary Methods" section can be downloaded here:
"Supplementary Tables" can be downloaded here:
DIFFERENTIAL GENE EXPRESSION
Below is the lists of differentially expressed genes in the developing urethra of mice upon gestational exposure to endocrine disruptors (genistein). All the results were obtained using a generalized linear model approach, using a single-channel design, and by applying an empirical Bayesian method to moderate variance across genes.
The list of genes differentially expressed in the urethra upon gestational exposure to different levels of genistein is reported below. The comparison was performed between high levels of genistein and normal diet, using the normal diet as the denominator to compute the fold-change.
FileName | Description |
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Urethra HIGH genistein vs NORMAL diet | HIGH genistein diet versus LOW Genistein
diet coefficient; top 2.5% genes by adjusted P-value |
Columns in the html file can be sorted by clicking the column header. The legend to the table headers is below:
ProbeName: Agilent Probe Identifier
logFC: Logarithmic transformation (base 2) of the fold-change between groups
AveExpr: Logarithmic transformation (base 2) of the average expression for the group
t: Moderated t-statistics
P.value: Unadjusted P value
adj.P.Val: Adjusted P value with the Benjamini-Hochberg method
B: B-statistics, log odds
EGID: Entrez Gene Identifier, linked to the NCBI ENTREZ Gene database
SYMBOL: Gene Symbol
GENENAME: Official Gene Name
UNIGENE: Unigene Cluster Identifier, linked to the NCBI Unigene database
ENSEMBL: ENSEMBL Gene Identifier, linked to the ENSEMBL database
MGI: MGI Accession number, linked to the MGI database
ANALYSIS OF FUNCTIONAL ANNOTATION
Analysis of Functional Annotation (AFA) results for the comparison between high and normal genistein gestational exposure. This analysis is conceptually analogous to Gene Set Enrichment Analysis (GSEA). Functional Gene Sets from various sources (i.e. GO, KEGG, Molecular signature database,SMD,PubMed, and so on) were used and their description is reported.
FileName | Description |
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Access results from AFA | ANALYSIS OF FUNCTIONAL ANNOTATION |
DOWNLOAD RAW DATA
Raw gene expression data can be downloaded at the link below
FileName | Description |
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Download | Tarbal archived of the raw gene expression data |