Test Results

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Gene Set Null Regulation of cytoplasmic and nuclear SMAD2/3 signaling

featureNameslogFCAveExprtP.Valueadj.P.ValBENTREZIDSYMBOLGENENAMEENSEMBL.HsaOMIM
1019-0.425610.67-7.9643.594e-142.36e-1320.971019CDK4cyclin-dependent kinase 4ENSG00000135446123829, 609048
10262.4678.00418.261.938e-509.553e-491041026CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)ENSG00000124762116899
102840.79046.8079.711.558e-191.448e-1833.1810284SAP18Sin3A-associated protein, 18kDaENSG00000150459602949
10401-0.68997.415-8.7261.942e-161.482e-1526.1210401PIAS3protein inhibitor of activated STAT, 3ENSG00000131788605987
10413-1.3138.131-16.526.428e-442.251e-4289.0410413YAP1Yes-associated protein 1ENSG00000137693606608
10499-1.8348.615-20.58.315e-597.043e-57123.210499NCOA2nuclear receptor coactivator 2ENSG00000140396601993
10511.28710.315.54.14e-401.199e-3880.291051CEBPBCCAAT/enhancer binding protein (C/EBP), betaENSG00000172216189965
112211.1065.46512.736.593e-301.09e-2856.911221DUSP10dual specificity phosphatase 10ENSG00000143507608867
112610.465211.589.4897.984e-197.129e-1831.5611261CHPcalcium binding protein P22ENSG00000187446606988
1387-2.1028.584-23.575.696e-709.194e-68148.81387CREBBPCREB binding proteinENSG00000005339180849, 600140
1452-0.311111.48-9.141.014e-178.394e-1729.041452CSNK1A1casein kinase 1, alpha 1ENSG00000113712600505
1457-0.74429.992-17.113.691e-461.44e-4494.181457CSNK2A1casein kinase 2, alpha 1 polypeptideENSG00000101266115440
1487-0.463510.5-7.3452e-121.167e-1117.011487CTBP1C-terminal binding protein 1ENSG00000159692602618
14903.1099.11526.493.629e-801.139e-77172.31490CTGFconnective tissue growth factorENSG00000118523121009
16010.42227.867.8328.583e-145.487e-1320.111601DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)ENSG00000153071601236
16470.686810.157.6812.31e-131.439e-1219.131647GADD45Agrowth arrest and DNA-damage-inducible, alphaENSG00000116717126335
16490.53817.8297.9992.845e-141.881e-1321.21649DDIT3DNA-damage-inducible transcript 3ENSG00000175197126337, 613488
18432.4678.38412.176.643e-289.886e-2752.321843DUSP1dual specificity phosphatase 1ENSG00000120129600714
19591.9214.8120.555.836e-595.039e-57123.61959EGR2early growth response 2ENSG00000122877129010, 145900, 605253, 607678
1977-0.74576.644-8.6184.14e-163.075e-1525.371977EIF4Eeukaryotic translation initiation factor 4EENSG00000151247133440
2005-0.66415.087-9.7948.283e-207.809e-1933.82005ELK4ELK4, ETS-domain protein (SRF accessory protein 1)ENSG00000158711600246
2033-1.5046.866-17.558.701e-483.779e-4697.912033EP300E1A binding protein p300ENSG00000100393114500, 180849, 602700, 613684
229260.49588.149.2026.468e-185.429e-1729.4922926ATF6activating transcription factor 6ENSG00000118217605537
23081.126.4812.832.877e-304.878e-2957.732308FOXO1forkhead box O1ENSG00000150907136533, 268220
23118-0.60788.522-8.1411.094e-147.45e-1422.1423118TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2ENSG00000055208605101, 612863
233091.0646.44510.53.904e-224.246e-2139.1223309SIN3BSIN3 transcription regulator homolog B (yeast)ENSG00000127511607777
233272.0827.09326.291.738e-795.233e-77170.723327NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG00000049759606384
235230.57645.8848.4989.514e-166.913e-1524.5523523CABIN1calcineurin binding protein 1ENSG00000099991604251
23531.0624.87315.967.591e-422.365e-4084.282353FOSFBJ murine osteosarcoma viral oncogene homologENSG00000170345164810
25341.5848.72519.78.022e-565.728e-54116.42534FYNFYN oncogene related to SRC, FGR, YESENSG00000010810137025
258052.8067.10432.245.767e-998.565e-96215.425805BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)ENSG00000095739604444
31641.7565.72922.071.472e-641.753e-62136.43164NR4A1nuclear receptor subfamily 4, group A, member 1ENSG00000123358139139
37261.38.47415.852.01e-416.16e-4083.313726JUNBjun B proto-oncogeneENSG00000171223165161
3837-0.766411.65-18.415.241e-512.69e-49105.33837KPNB1karyopherin (importin) beta 1ENSG00000108424602738
38561.2819.5797.6173.507e-132.16e-1218.723856KRT8keratin 8ENSG00000170421148060, 215600
38801.13611.429.2036.421e-185.394e-1729.493880KRT19keratin 19ENSG00000171345148020
39320.57934.339.7491.162e-191.084e-1833.473932LCKlymphocyte-specific protein tyrosine kinaseENSG00000182866153390
40670.87526.7447.8577.279e-144.673e-1320.274067LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologENSG00000254087165120
4088-1.079.531-22.381.09e-651.395e-631394088SMAD3SMAD family member 3ENSG00000166949603109, 613795
4089-0.87616.918-8.9025.563e-174.391e-1627.364089SMAD4SMAD family member 4ENSG00000141646139210, 174900, 175050, 600993
41371.395.2820.112.292e-571.786e-55119.94137MAPTmicrotubule-associated protein tauENSG00000257437, ENSG00000186868157140, 168600, 172700, 260540, 600274, 601104
41490.74049.177.8656.914e-144.446e-1320.324149MAXMYC associated factor XENSG00000125952154950, 171300
42081.0777.60811.821.118e-261.56e-2549.514208MEF2Cmyocyte enhancer factor 2CENSG00000081189600662, 613443
42151.0867.86914.068.91e-351.948e-3368.064215MAP3K3mitogen-activated protein kinase kinase kinase 3ENSG00000198909602539
4216-0.67777.796-8.7951.188e-169.202e-1626.614216MAP3K4mitogen-activated protein kinase kinase kinase 4ENSG00000085511602425
42861.0417.08915.253.599e-399.814e-3878.144286MITFmicrophthalmia-associated transcription factorENSG00000187098103470, 103500, 156845, 193510
44350.62044.6910.051.254e-201.242e-1935.684435CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1ENSG00000125931300149
46161.2838.3519.5754.223e-193.827e-1832.194616GADD45Bgrowth arrest and DNA-damage-inducible, betaENSG00000099860604948
466-1.6898.875-16.313.949e-431.327e-4187.23466ATF1activating transcription factor 1ENSG00000123268123803
47720.47675.1539.3192.76e-182.379e-1730.334772NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1ENSG00000131196600489
47750.53826.9226.9392.491e-111.341e-1014.534775NFATC3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3ENSG00000072736602698
50541.4638.572101.742e-201.707e-1935.355054SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1ENSG00000106366173360, 613329
50630.88515.6529.4141.383e-181.217e-1731.015063PAK3p21 protein (Cdc42/Rac)-activated kinase 3ENSG00000077264300142, 300558
508550.67836.048.9863.056e-172.461e-1627.9550855PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)ENSG00000102981607484
513472.0228.07223.682.368e-703.996e-68149.751347TAOK3TAO kinase 3ENSG00000135090NA
51701.4168.97912.11.141e-271.68e-2651.785170PDPK13-phosphoinositide dependent protein kinase-1ENSG00000140992605213
51776-0.60055.384-10.621.573e-221.748e-2140.0251776ZAKsterile alpha motif and leucine zipper containing kinase AZKENSG00000091436609479
52921.1455.95913.64.432e-338.729e-3264.175292PIM1pim-1 oncogeneENSG00000137193164960
53211.2795.7789.6891.809e-191.675e-1833.035321PLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent)ENSG00000116711600522
53710.75945.90213.132.273e-314.09e-3060.255371PMLpromyelocytic leukemiaENSG00000140464102578
55660.4379.5497.2473.702e-122.108e-1116.45566PRKACAprotein kinase, cAMP-dependent, catalytic, alphaENSG00000072062601639
55781.4387.31319.931.092e-568.22e-55118.45578PRKCAprotein kinase C, alphaENSG00000154229176960
55801.8547.47820.546.059e-595.191e-57123.55580PRKCDprotein kinase C, deltaENSG00000163932176977
55802-0.38998.344-7.0241.474e-118.05e-1115.0455802DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)ENSG00000162290607010
55830.81228.55510.523.299e-223.601e-2139.295583PRKCHprotein kinase C, etaENSG00000027075601367, 605437
55900.68848.55711.664.121e-265.577e-2548.215590PRKCZprotein kinase C, zetaENSG00000067606176982
56061.8618.22117.653.674e-481.643e-4698.775606MAP2K3mitogen-activated protein kinase kinase 3ENSG00000034152602315
56081.0267.95510.78.344e-239.383e-2240.655608MAP2K6mitogen-activated protein kinase kinase 6ENSG00000108984601254
57701.6878.30817.442.234e-479.389e-4696.975770PTPN1protein tyrosine phosphatase, non-receptor type 1ENSG00000196396125853, 176885
58190-1.4938.574-25.141.675e-754.146e-73161.558190CTDSP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1ENSG00000144579605323
5894-0.8249.525-11.335.619e-257.147e-2445.625894RAF1v-raf-1 murine leukemia viral oncogene homolog 1ENSG00000132155164760, 611553, 611554
5928-1.1619.46-7.32.646e-121.525e-1116.735928RBBP4retinoblastoma binding protein 4ENSG00000162521602923
5933-1.4746.7-15.494.557e-401.315e-3880.25933RBL1retinoblastoma-like 1 (p107)ENSG00000080839116957
595-1.00710.02-9.4431.116e-189.892e-1831.23595CCND1cyclin D1ENSG00000110092114500, 151400, 168461, 193300, 254500
598-1.4289.808-18.079.273e-504.395e-48102.4598BCL2L1BCL2-like 1ENSG00000171552600039
65481.6268.51919.081.614e-539.668e-52111.16548SLC9A1solute carrier family 9 (sodium/hydrogen exchanger), member 1ENSG00000090020107310
6654-0.72968.464-8.712.174e-161.652e-1526.016654SOS1son of sevenless homolog 1 (Drosophila)ENSG00000115904135300, 163955, 182530, 610733
6670-0.757310.13-13.93.593e-347.593e-3366.676670SP3Sp3 transcription factorENSG00000172845601804
6714-1.0387.216-9.0961.393e-171.141e-1628.736714SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)ENSG00000197122190090
68850.51357.8898.5556.402e-164.712e-1524.946885MAP3K7mitogen-activated protein kinase kinase kinase 7ENSG00000135341602614
7027-0.601910.46-12.437.62e-291.187e-2754.477027TFDP1transcription factor Dp-1ENSG00000198176189902
7030-0.63729.491-9.2265.441e-184.6e-1729.667030TFE3transcription factor binding to IGHM enhancer 3ENSG00000068323300854, 314310, 605074
70491.1456.7669.8764.49e-204.293e-1934.417049TGFBR3transforming growth factor, beta receptor IIIENSG00000069702600742
7157-0.44384.283-7.6512.808e-131.738e-1218.947157TP53tumor protein p53ENSG00000141510114480, 114500, 114550, 151623, 161550, 191170, 202300, 259500, 260350, 260500, 607107
74210.7158.0867.7571.407e-138.896e-1319.627421VDRvitamin D (1, 25- dihydroxyvitamin D3) receptorENSG00000111424166710, 277440, 601769
7514-1.02611.74-32.121.358e-981.891e-95214.57514XPO1exportin 1 (CRM1 homolog, yeast)ENSG00000082898602559
7533-1.1348.591-11.887.038e-279.942e-2649.977533YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideENSG00000128245113508
8010.492111.467.1397.262e-124.059e-1115.74801CALM1calmodulin 1 (phosphorylase kinase, delta)ENSG00000143933, ENSG00000160014, ENSG00000198668114180
8061-2.16511.23-24.938.883e-752.061e-72159.98061FOSL1FOS-like antigen 1ENSG00000175592136515
85690.99338.53918.415.309e-512.719e-49105.38569MKNK1MAP kinase interacting serine/threonine kinase 1ENSG00000079277606724
857-0.509912.01-10.832.868e-233.331e-2241.71857CAV1caveolin 1, caveolae protein, 22kDaENSG00000105974601047, 612526
865-0.544110.03-11.625.567e-267.462e-2547.91865CBFBcore-binding factor, beta subunitENSG00000067955121360, 601626
8680.93228.4914.512.034e-364.806e-3571.83868CBLBCbl proto-oncogene, E3 ubiquitin protein ligase BENSG00000114423604491
88190.54749.5627.4441.064e-126.335e-1217.638819SAP30Sin3A-associated protein, 30kDaENSG00000164105603378
9064-0.61625.886-8.8458.346e-176.519e-1626.969064MAP3K6mitogen-activated protein kinase kinase kinase 6ENSG00000142733604468
92610.78839.76712.552.757e-294.391e-2855.489261MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2ENSG00000162889602006
9392-0.64957.614-10.842.693e-233.131e-2241.779392TGFBRAP1transforming growth factor, beta receptor associated protein 1ENSG00000135966606237
9611-0.54599.426-7.6512.805e-131.737e-1218.949611NCOR1nuclear receptor corepressor 1ENSG00000141027600849
9765-0.66437.185-7.72.041e-131.278e-1219.259765ZFYVE16zinc finger, FYVE domain containing 16ENSG00000039319608880
9972-0.77099.964-13.451.605e-323.052e-3162.899972NUP153nucleoporin 153kDaENSG00000124789603948