Test Results

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Gene Set Null Regulation of nuclear SMAD2/3 signaling

featureNameslogFCAveExprtP.Valueadj.P.ValBENTREZIDSYMBOLGENENAMEENSEMBL.HsaOMIM
10454-0.19934.997-1.460.14520.9609-4.42610454TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 1ENSG00000100324602615
109120.18114.4191.7760.076680.9609-4.22510912GADD45Ggrowth arrest and DNA-damage-inducible, gammaENSG00000130222604949
13900.38578.8132.0890.037560.9609-3.9891390CREMcAMP responsive element modulatorENSG00000095794123812
14320.56886.9351.9680.050020.9609-4.0851432MAPK14mitogen-activated protein kinase 14ENSG00000112062600289
14370.40144.3752.420.016120.9609-3.71437CSF2colony stimulating factor 2 (granulocyte-macrophage)ENSG00000164400138960
1452-0.193811.39-1.7920.074220.9609-4.2141452CSNK1A1casein kinase 1, alpha 1ENSG00000113712600505
1487-0.4669.022-1.80.072830.9609-4.2081487CTBP1C-terminal binding protein 1ENSG00000159692602618
1490-0.57389.115-1.7820.075780.9609-4.2211490CTGFconnective tissue growth factorENSG00000118523121009
16010.36317.4241.6530.099330.9609-4.3081601DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)ENSG00000153071601236
16060.57084.8072.1080.035910.9609-3.9741606DGKAdiacylglycerol kinase, alpha 80kDaENSG00000065357125855
18270.13773.7731.4360.1520.9609-4.441827RCAN1regulator of calcineurin 1ENSG00000159200602917
1869-0.32046.356-1.4990.13490.9609-4.4031869E2F1E2F transcription factor 1ENSG00000101412189971
19580.81594.7671.6130.10780.9609-4.3331958EGR1early growth response 1ENSG00000120738128990
2033-0.53327.683-2.1810.029970.9609-3.9132033EP300E1A binding protein p300ENSG00000100393114500, 180849, 602700, 613684
207-0.28259.263-1.6370.10260.9609-4.318207AKT1v-akt murine thymoma viral oncogene homolog 1ENSG00000142208114480, 114500, 164730, 167000, 176920, 181500, 604370
2099-0.29784.373-2.3930.017340.9609-3.7252099ESR1estrogen receptor 1ENSG00000091831133430, 157300, 608446
21151.3025.3913.860.00013930.3879-1.9962115ETV1ets variant 1ENSG00000006468600541
22680.20354.2921.5490.12240.9609-4.3732268FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologENSG00000000938164940
2290-0.37254.2-2.3260.02070.9609-3.7862290FOXG1forkhead box G1ENSG00000176165164874, 613454
23309-0.45036.445-1.6190.10650.9609-4.3323309SIN3BSIN3 transcription regulator homolog B (yeast)ENSG00000127511607777
23327-0.3357.093-1.5420.12420.9609-4.37823327NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG00000049759606384
23523-0.59056.137-2.7080.0071640.9609-3.41623523CABIN1calcineurin binding protein 1ENSG00000099991604251
23530.39884.8732.1860.029590.9609-3.9092353FOSFBJ murine osteosarcoma viral oncogene homologENSG00000170345164810
23770-0.56076.828-1.9720.049570.9609-4.08223770FKBP8FK506 binding protein 8, 38kDaENSG00000105701604840
25805-0.4687.104-1.9590.051030.9609-4.09225805BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)ENSG00000095739604444
2664-0.4729.372-2.8360.0048840.9609-3.2812664GDI1GDP dissociation inhibitor 1ENSG00000203879300104, 300849, 309541
269590.35628.1411.7760.076690.9609-4.22526959HBP1HMG-box transcription factor 1ENSG00000105856NA
31640.27364.9671.8420.066470.9609-4.1783164NR4A1nuclear receptor subfamily 4, group A, member 1ENSG00000123358139139
3172-0.21834.551-1.4110.15940.9609-4.4543172HNF4Ahepatocyte nuclear factor 4, alphaENSG00000101076125850, 125853, 600281, 606391
3310.29185.0171.7230.085930.9609-4.262331XIAPX-linked inhibitor of apoptosisENSG00000101966300079, 300635
3312-0.14213.34-2.0030.046110.9609-4.0583312HSPA8heat shock 70kDa protein 8ENSG00000109971600816
3558-0.52014.72-1.4810.13970.9609-4.4143558IL2interleukin 2ENSG00000109471147680
3565-0.15073.905-1.5320.12660.9609-4.3843565IL4interleukin 4ENSG00000113520147780
35761.2388.2971.520.12960.9609-4.3913576IL8interleukin 8ENSG00000169429146930
367-0.18514.654-1.590.11290.9609-4.348367ARandrogen receptorENSG00000169083176807, 300068, 300633, 312300, 313200, 313700
38800.513911.421.5180.13010.9609-4.3923880KRT19keratin 19ENSG00000171345148020
3925-0.7396.414-1.5890.11310.9609-4.3493925STMN1stathmin 1ENSG00000117632151442
4067-0.4516.436-1.5030.13390.9609-4.4014067LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologENSG00000254087165120
4088-0.27249.531-2.0770.038650.9609-3.9994088SMAD3SMAD family member 3ENSG00000166949603109, 613795
4094-0.2734.184-1.4760.1410.9609-4.4174094MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)ENSG00000178573177075, 610202
4149-0.38710.53-2.6730.0079410.9609-3.4534149MAXMYC associated factor XENSG00000125952154950, 171300
4214-0.44744.64-1.6930.091440.9609-4.2814214MAP3K1mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligaseENSG00000095015600982, 613762
4215-0.31977.869-1.5090.13230.9609-4.3974215MAP3K3mitogen-activated protein kinase kinase kinase 3ENSG00000198909602539
42170.55565.0082.2350.026180.9609-3.8674217MAP3K5mitogen-activated protein kinase kinase kinase 5ENSG00000197442602448
4720.97236.441.7640.078760.9609-4.234472ATMataxia telangiectasia mutatedENSG00000149311114480, 208900, 607585
4843-0.18684.164-1.9580.05120.9609-4.0934843NOS2nitric oxide synthase 2, inducibleENSG00000007171145500, 163730, 248310, 611162
5062-0.35667.174-1.570.11760.9609-4.3615062PAK2p21 protein (Cdc42/Rac)-activated kinase 2ENSG00000180370605022
50943-0.3154.389-2.0910.037340.9609-3.98750943FOXP3forkhead box P3ENSG00000049768222100, 300292, 304790
51588-0.43575.973-1.5880.11350.9609-4.3551588PIAS4protein inhibitor of activated STAT, 4ENSG00000105229605989
51776-0.25015.384-1.6120.10810.9609-4.33451776ZAKsterile alpha motif and leucine zipper containing kinase AZKENSG00000091436609479
5371-0.23584.471-1.4680.14310.9609-4.4215371PMLpromyelocytic leukemiaENSG00000140464102578
54680.411810.111.8760.061650.9609-4.1545468PPARGperoxisome proliferator-activated receptor gammaENSG00000132170125853, 137800, 151660, 601487, 601665, 604367, 609338
5566-0.27379.549-1.6540.099210.9609-4.3075566PRKACAprotein kinase, cAMP-dependent, catalytic, alphaENSG00000072062601639
55820.18223.8282.0590.040380.9609-4.0135582PRKCGprotein kinase C, gammaENSG00000126583176980, 605361
55830.73776.6622.4120.016450.9609-3.7075583PRKCHprotein kinase C, etaENSG00000027075601367, 605437
55880.29384.3752.0130.045040.9609-4.055588PRKCQprotein kinase C, thetaENSG00000065675600448
5592-0.19234.201-1.5410.12440.9609-4.3785592PRKG1protein kinase, cGMP-dependent, type IENSG00000185532176894
5594-0.18929.713-1.740.082830.9609-4.255594MAPK1mitogen-activated protein kinase 1ENSG00000100030176948
56000.3124.9031.4620.14470.9609-4.4255600MAPK11mitogen-activated protein kinase 11ENSG00000185386602898
56030.70737.6331.7340.0840.9609-4.2545603MAPK13mitogen-activated protein kinase 13ENSG00000156711602899
5606-0.48449.058-1.7030.089650.9609-4.2755606MAP2K3mitogen-activated protein kinase kinase 3ENSG00000034152602315
56080.42417.9551.6110.10810.9609-4.3355608MAP2K6mitogen-activated protein kinase kinase 6ENSG00000108984601254
571540.47385.3722.0710.039180.9609-4.00357154SMURF1SMAD specific E3 ubiquitin protein ligase 1ENSG00000198742605568
57700.22584.2712.0230.0440.9609-4.0425770PTPN1protein tyrosine phosphatase, non-receptor type 1ENSG00000196396125853, 176885
58190-0.33068.574-2.0280.043420.9609-4.03858190CTDSP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1ENSG00000144579605323
58680.65057.9041.4820.13930.9609-4.4135868RAB5ARAB5A, member RAS oncogene familyENSG00000144566179512
5879-0.256912.69-2.2030.028330.9609-3.8945879RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)ENSG00000136238602048
58990.63847.7381.9520.051860.9609-4.0975899RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)ENSG00000144118179551
59280.63389.461.4530.14740.9609-4.435928RBBP4retinoblastoma binding protein 4ENSG00000162521602923
596-0.25694.863-1.4040.16150.9609-4.458596BCL2B-cell CLL/lymphoma 2ENSG00000171791151430
598-0.63989.808-2.950.003430.9609-3.155598BCL2L1BCL2-like 1ENSG00000171552600039
6400.22234.0552.2340.026260.9609-3.868640BLKB lymphoid tyrosine kinaseENSG00000136573191305, 613375
64160.57878.0912.0590.040410.9609-4.0146416MAP2K4mitogen-activated protein kinase kinase 4ENSG00000065559601335
64980.334.481.4270.15460.9609-4.4456498SKILSKI-like oncogeneENSG00000136603165340
66540.32376.1631.3880.16620.9609-4.4666654SOS1son of sevenless homolog 1 (Drosophila)ENSG00000115904135300, 163955, 182530, 610733
6711-0.440211.24-2.8360.0048750.9609-3.286711SPTBN1spectrin, beta, non-erythrocytic 1ENSG00000115306182790
6722-0.36698.306-1.9570.05130.9609-4.0936722SRFserum response factor (c-fos serum response element-binding transcription factor)ENSG00000112658600589
6929-0.44786.553-2.3590.018950.9609-3.7566929TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)ENSG00000071564147141
7030-0.33927.365-1.6220.10580.9609-4.3287030TFE3transcription factor binding to IGHM enhancer 3ENSG00000068323300854, 314310, 605074
70460.32764.5092.280.023330.9609-3.8277046TGFBR1transforming growth factor, beta receptor 1ENSG00000106799132800, 190181, 608967, 609129, 609192
71240.20554.1121.8510.065190.9609-4.1727124TNFtumor necrosis factorENSG00000228978, ENSG00000232810, ENSG00000204490, ENSG00000223952, ENSG00000230108, ENSG00000228321, ENSG00000206439, ENSG00000228849157300, 191160, 248310, 600807, 611162
71570.22514.3611.7560.080040.9609-4.2397157TP53tumor protein p53ENSG00000141510114480, 114500, 114550, 151623, 161550, 191170, 202300, 259500, 260350, 260500, 607107
7249-0.48187.185-2.0290.043320.9609-4.0377249TSC2tuberous sclerosis 2ENSG00000103197191092, 191100, 606690
7514-0.208711.74-2.3810.017880.9609-3.7367514XPO1exportin 1 (CRM1 homolog, yeast)ENSG00000082898602559
75250.218911.071.5580.12030.9609-4.3687525YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1ENSG00000176105164880
7531-0.441210.74-1.6780.094480.9609-4.2927531YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideENSG00000108953247200, 605066
75340.716111.841.4710.14230.9609-4.427534YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSG00000164924601288
7709-0.25274.936-1.3780.16920.9609-4.4727709ZBTB17zinc finger and BTB domain containing 17ENSG00000116809604084
78670.36258.2281.8340.067590.9609-4.1847867MAPKAPK3mitogen-activated protein kinase-activated protein kinase 3ENSG00000114738602130
79589-0.3434.07-2.3950.017230.9609-3.72379589RNF128ring finger protein 128, E3 ubiquitin protein ligaseENSG00000133135300439
801-0.360811.46-1.9070.057440.9609-4.131801CALM1calmodulin 1 (phosphorylase kinase, delta)ENSG00000143933, ENSG00000160014, ENSG00000198668114180
8061-0.558811.23-2.3460.019640.9609-3.7688061FOSL1FOS-like antigen 1ENSG00000175592136515
808-0.63889.506-2.4070.016680.9609-3.712808CALM3calmodulin 3 (phosphorylase kinase, delta)ENSG00000143933, ENSG00000160014, ENSG00000198668114183
814-0.34594.896-1.7920.074110.9609-4.214814CAMK4calcium/calmodulin-dependent protein kinase IVENSG00000152495114080
860-0.18424.008-1.9980.046620.9609-4.061860RUNX2runt-related transcription factor 2ENSG00000124813119600, 600211
861-0.28154.899-1.6890.092220.9609-4.284861RUNX1runt-related transcription factor 1ENSG00000159216151385, 180300, 601399, 601626
864-0.51475.589-2.6190.0092680.9609-3.507864RUNX3runt-related transcription factor 3ENSG00000020633600210
8648-0.40357.378-2.0270.043530.9609-4.0398648NCOA1nuclear receptor coactivator 1ENSG00000084676602691
865-0.316410.03-2.4630.014360.9609-3.66865CBFBcore-binding factor, beta subunitENSG00000067955121360, 601626
8819-0.21734.094-2.3320.020350.9609-3.788819SAP30Sin3A-associated protein, 30kDaENSG00000164105603378