| Gene Set Name | 
      GeneSetDescription | 
      Value | 
      Gene Set Size | 
      Corrected Value | 
      Ranking | 
      Description | 
      URL | 
     
     
      | Broad PEREZ_TP53_TARGETS | 
      
       View Gene Set
       | 
      2.675e-13 | 
      1066 | 
      6.4e-10 | 
      1 | 
      Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [Gene ID=7157] off adenoviral vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN | 
      
       View Gene Set
       | 
      5.564e-12 | 
      485 | 
      6.655e-09 | 
      2 | 
      Genes down-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad STEIN_ESRRA_TARGETS_UP | 
      
       View Gene Set
       | 
      2.717e-11 | 
      368 | 
      2.167e-08 | 
      3 | 
      Genes up-regulated by ESRRA [Gene ID=2101] only. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP | 
      
       View Gene Set
       | 
      2.858e-10 | 
      399 | 
      1.709e-07 | 
      4 | 
      Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad RIGGI_EWING_SARCOMA_PROGENITOR_DN | 
      
       View Gene Set
       | 
      9.254e-10 | 
      178 | 
      4.427e-07 | 
      5 | 
      
       Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
       2321] fusion protein.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad RIGGI_EWING_SARCOMA_PROGENITOR_UP | 
      
       View Gene Set
       | 
      1.666e-09 | 
      399 | 
      6.64e-07 | 
      6 | 
      
       Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
       2321] fusion protein.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN | 
      
       View Gene Set
       | 
      4.211e-09 | 
      532 | 
      1.439e-06 | 
      7 | 
      Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad PEREZ_TP63_TARGETS | 
      
       View Gene Set
       | 
      2.455e-08 | 
      328 | 
      7.34e-06 | 
      8 | 
      Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_HUMAN_MITODB_6_2002 | 
      
       View Gene Set
       | 
      7.664e-08 | 
      420 | 
      2.037e-05 | 
      9 | 
      Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HELLER_HDAC_TARGETS_UP | 
      
       View Gene Set
       | 
      9.883e-08 | 
      268 | 
      2.364e-05 | 
      10 | 
      Genes up-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP | 
      
       View Gene Set
       | 
      4.885e-07 | 
      422 | 
      9.932e-05 | 
      11 | 
      Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 | 
      
       View Gene Set
       | 
      4.983e-07 | 
      681 | 
      9.932e-05 | 
      11 | 
      
       The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
       2064].
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad STEIN_ESRRA_TARGETS | 
      
       View Gene Set
       | 
      5.634e-07 | 
      508 | 
      0.0001037 | 
      13 | 
      Genes regulated by ESRRA [Gene ID=2101] in MCF-7 cells (breast cancer). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad PEREZ_TP53_AND_TP63_TARGETS | 
      
       View Gene Set
       | 
      6.683e-07 | 
      187 | 
      0.0001142 | 
      14 | 
      Genes up-regulated in HMEC cells (primary mammary epithelium) upon expression of both of TP53 [Gene ID=7157] and the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vectors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_MITOCHONDRIA | 
      
       View Gene Set
       | 
      8.516e-07 | 
      433 | 
      0.0001358 | 
      15 | 
      Mitochondrial genes | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER | 
      
       View Gene Set
       | 
      9.721e-07 | 
      138 | 
      0.0001453 | 
      16 | 
      The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP | 
      
       View Gene Set
       | 
      1.071e-06 | 
      87 | 
      0.0001508 | 
      17 | 
      Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BENPORATH_ES_WITH_H3K27ME3 | 
      
       View Gene Set
       | 
      1.204e-06 | 
      1094 | 
      0.0001601 | 
      18 | 
      
       Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells
       as identified by ChIP on chip.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LEE_EARLY_T_LYMPHOCYTE_UP | 
      
       View Gene Set
       | 
      2.103e-06 | 
      80 | 
      0.0002647 | 
      19 | 
      Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad DELYS_THYROID_CANCER_DN | 
      
       View Gene Set
       | 
      3.375e-06 | 
      213 | 
      0.0004037 | 
      20 | 
      Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad DODD_NASOPHARYNGEAL_CARCINOMA_UP | 
      
       View Gene Set
       | 
      4.44e-06 | 
      1582 | 
      0.0004828 | 
      21 | 
      Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LINDGREN_BLADDER_CANCER_CLUSTER_2B | 
      
       View Gene Set
       | 
      4.296e-06 | 
      384 | 
      0.0004828 | 
      21 | 
      Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LINDGREN_BLADDER_CANCER_CLUSTER_3_UP | 
      
       View Gene Set
       | 
      5.906e-06 | 
      314 | 
      0.0006142 | 
      23 | 
      Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMID_BREAST_CANCER_BASAL_DN | 
      
       View Gene Set
       | 
      6.267e-06 | 
      664 | 
      0.0006246 | 
      24 | 
      Genes down-regulated in basal subtype of breast cancer samles. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMITH_TERT_TARGETS_DN | 
      
       View Gene Set
       | 
      8.384e-06 | 
      71 | 
      0.0008022 | 
      25 | 
      Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [Gene ID=7015] off a retroviral vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMID_BREAST_CANCER_NORMAL_LIKE_UP | 
      
       View Gene Set
       | 
      1.071e-05 | 
      459 | 
      0.0009851 | 
      26 | 
      Genes up-regulated in the normal-like subtype of breast cancer. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LEE_LIVER_CANCER_SURVIVAL_UP | 
      
       View Gene Set
       | 
      1.138e-05 | 
      130 | 
      0.001009 | 
      27 | 
      Genes highly expressed in hepatocellular carcinoma with good survival. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BENPORATH_SUZ12_TARGETS | 
      
       View Gene Set
       | 
      1.542e-05 | 
      1011 | 
      0.001284 | 
      28 | 
      Set 'Suz12 targets': genes identified by ChIP on chip as targets of the Polycomb protein SUZ12 [Gene ID=23512] in human embryonic stem cells. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad WALLACE_PROSTATE_CANCER_RACE_UP | 
      
       View Gene Set
       | 
      1.61e-05 | 
      288 | 
      0.001284 | 
      28 | 
      Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ZHAN_MULTIPLE_MYELOMA_PR_UP | 
      
       View Gene Set
       | 
      1.589e-05 | 
      43 | 
      0.001284 | 
      28 | 
      Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad RODWELL_AGING_KIDNEY_NO_BLOOD_DN | 
      
       View Gene Set
       | 
      1.932e-05 | 
      119 | 
      0.001491 | 
      31 | 
      
       Genes whose expression decreases with age in normal kidney
       excluding those with higher expression in blood.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP | 
      
       View Gene Set
       | 
      2.629e-05 | 
      317 | 
      0.001965 | 
      32 | 
      Genes up-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHANG_CYCLING_GENES | 
      
       View Gene Set
       | 
      2.764e-05 | 
      49 | 
      0.002003 | 
      33 | 
      Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HUTTMANN_B_CLL_POOR_SURVIVAL_UP | 
      
       View Gene Set
       | 
      3.057e-05 | 
      268 | 
      0.002151 | 
      34 | 
      
       Up-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [Gene ID=7535
       952]
       which are associated with poor survival.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ONDER_CDH1_TARGETS_2_UP | 
      
       View Gene Set
       | 
      3.262e-05 | 
      249 | 
      0.002229 | 
      35 | 
      Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad VECCHI_GASTRIC_CANCER_EARLY_DN | 
      
       View Gene Set
       | 
      3.556e-05 | 
      346 | 
      0.002332 | 
      36 | 
      Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 | 
      
       View Gene Set
       | 
      3.607e-05 | 
      377 | 
      0.002332 | 
      36 | 
      
       The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
       2064].
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HOSHIDA_LIVER_CANCER_SUBCLASS_S3 | 
      
       View Gene Set
       | 
      4.785e-05 | 
      266 | 
      0.003012 | 
      38 | 
      Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad WONG_MITOCHONDRIA_GENE_MODULE | 
      
       View Gene Set
       | 
      5.146e-05 | 
      208 | 
      0.003156 | 
      39 | 
      Genes that comprise the mitochondria gene module | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN | 
      
       View Gene Set
       | 
      6.124e-05 | 
      47 | 
      0.003662 | 
      40 | 
      Genes down-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ALCALAY_AML_BY_NPM1_LOCALIZATION_DN | 
      
       View Gene Set
       | 
      6.761e-05 | 
      179 | 
      0.003945 | 
      41 | 
      Genes changed in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [Gene ID=4869]: cytoplasmic vs. nucleolar. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CASTELLANO_NRAS_TARGETS_UP | 
      
       View Gene Set
       | 
      9.081e-05 | 
      59 | 
      0.005051 | 
      42 | 
      Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [Gene ID=4893] knockout mice. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP | 
      
       View Gene Set
       | 
      8.984e-05 | 
      135 | 
      0.005051 | 
      42 | 
      
       Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation
       high levels of serum AFP [Gene ID=174]
       and chromosomal instability.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP | 
      
       View Gene Set
       | 
      9.845e-05 | 
      180 | 
      0.005352 | 
      44 | 
      Genes up-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LANDIS_ERBB2_BREAST_TUMORS_324_DN | 
      
       View Gene Set
       | 
      0.0001025 | 
      137 | 
      0.005451 | 
      45 | 
      The 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [Gene ID=2064]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BROWNE_HCMV_INFECTION_48HR_UP | 
      
       View Gene Set
       | 
      0.0001264 | 
      175 | 
      0.006571 | 
      46 | 
      
       Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 48 h time point that were not up-regulated at the previous time point
       24 h.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BERENJENO_TRANSFORMED_BY_RHOA_DN | 
      
       View Gene Set
       | 
      0.0001521 | 
      353 | 
      0.007741 | 
      47 | 
      Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by  expression of contitutively active (Q63L) form of RHOA [Gene ID=387] off plasmid vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN | 
      
       View Gene Set
       | 
      0.0001801 | 
      154 | 
      0.008977 | 
      48 | 
      
       Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation
       high levels of serum AFP [Gene ID=174]
       and chromosomal instability.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BLALOCK_ALZHEIMERS_DISEASE_DN | 
      
       View Gene Set
       | 
      0.0002042 | 
      1209 | 
      0.009968 | 
      49 | 
      Genes down-regulated in brain from patients with Alzheimer's disease. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad TIEN_INTESTINE_PROBIOTICS_24HR_UP | 
      
       View Gene Set
       | 
      0.0002133 | 
      537 | 
      0.0102 | 
      50 | 
      Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BILD_E2F3_ONCOGENIC_SIGNATURE | 
      
       View Gene Set
       | 
      0.000232 | 
      222 | 
      0.01087 | 
      51 | 
      Genes selected in supervised analyses to discriminate cells expressing E2F3 [Gene ID=1871] from control cells expressing GFP. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHUNG_BLISTER_CYTOTOXICITY_UP | 
      
       View Gene Set
       | 
      0.0002408 | 
      126 | 
      0.01087 | 
      51 | 
      Genes changed in blister cells from patients with adverse drug reactions (ADR). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad POOLA_INVASIVE_BREAST_CANCER_UP | 
      
       View Gene Set
       | 
      0.0002375 | 
      278 | 
      0.01087 | 
      51 | 
      Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad KOYAMA_SEMA3B_TARGETS_DN | 
      
       View Gene Set
       | 
      0.0002884 | 
      286 | 
      0.01277 | 
      54 | 
      Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [Gene ID=7869]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BENPORATH_PRC2_TARGETS | 
      
       View Gene Set
       | 
      0.000339 | 
      636 | 
      0.01448 | 
      55 | 
      Set 'PRC2 targets': Polycomb Repression Complex 2 (PRC) targets; identified by ChIP on chip on human embryonic stem cells as genes that: posess the trimethylated H3K27 mark in their promoters and are bound by SUZ12 [Gene ID=23512] and EED [Gene ID=8726] Polycomb proteins. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMID_BREAST_CANCER_LUMINAL_B_UP | 
      
       View Gene Set
       | 
      0.0003371 | 
      162 | 
      0.01448 | 
      55 | 
      Genes up-regulated in the luminal B subtype of breast cancer. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_TCA | 
      
       View Gene Set
       | 
      0.0003763 | 
      15 | 
      0.01579 | 
      57 | 
      Tricarboxylic acid related genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_VOXPHOS | 
      
       View Gene Set
       | 
      0.0004092 | 
      82 | 
      0.01688 | 
      58 | 
      Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP | 
      
       View Gene Set
       | 
      0.0004709 | 
      75 | 
      0.01886 | 
      59 | 
      
       Up-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [Gene ID=4297
       4299] or AF4-MLL fusion proteins alone
       and those expressing both fusion proteins.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad RICKMAN_HEAD_AND_NECK_CANCER_A | 
      
       View Gene Set
       | 
      0.000473 | 
      91 | 
      0.01886 | 
      59 | 
      Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad KIM_LRRC3B_TARGETS | 
      
       View Gene Set
       | 
      0.0005068 | 
      30 | 
      0.01987 | 
      61 | 
      Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN | 
      
       View Gene Set
       | 
      0.0005166 | 
      258 | 
      0.01993 | 
      62 | 
      Genes down-regulated in macrophages by P.gingivalis FimA pathogen. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP | 
      
       View Gene Set
       | 
      0.0005257 | 
      38 | 
      0.01996 | 
      63 | 
      Genes up-regulated in secondary APL (acute promyelocytic leukemia) compared to the de novo tumors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP | 
      
       View Gene Set
       | 
      0.0005511 | 
      143 | 
      0.0206 | 
      64 | 
      Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LIU_PROSTATE_CANCER_DN | 
      
       View Gene Set
       | 
      0.000573 | 
      446 | 
      0.02077 | 
      65 | 
      Genes down-regulated in prostate cancer samples. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad DOUGLAS_BMI1_TARGETS_UP | 
      
       View Gene Set
       | 
      0.0005692 | 
      497 | 
      0.02077 | 
      65 | 
      
       Genes up-regulated in A4573 cells (Ewing's sarcoma
       ESFT) after knockdown of BMI1 [Gene ID=648] by RNAi.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN | 
      
       View Gene Set
       | 
      0.000598 | 
      73 | 
      0.02135 | 
      67 | 
      Top 100 probe sets contrubuting to the negative side of the 1st principal component; predominantly associated with synovial sarcoma and myxoid/round cell liposarcoma samples. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HELLER_SILENCED_BY_METHYLATION_UP | 
      
       View Gene Set
       | 
      0.0006183 | 
      247 | 
      0.0215 | 
      68 | 
      Genes up-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHANDRAN_METASTASIS_DN | 
      
       View Gene Set
       | 
      0.0006201 | 
      90 | 
      0.0215 | 
      68 | 
      Genes down-regulated in metastatic tumors from the whole panel of patients with prostate cancer. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MONTERO_THYROID_CANCER_POOR_SURVIVAL_UP | 
      
       View Gene Set
       | 
      0.0006387 | 
      10 | 
      0.02183 | 
      70 | 
      Up-regulated genes predicting poor survival of patients with thyroid carcinoma. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BOYAULT_LIVER_CANCER_SUBCLASS_G3_DN | 
      
       View Gene Set
       | 
      0.0006499 | 
      51 | 
      0.02189 | 
      71 | 
      
       Down-regulated genes in hepatocellular carcinoma (HCC) subclass G3
       defined by unsupervised clustering.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BAELDE_DIABETIC_NEPHROPATHY_DN | 
      
       View Gene Set
       | 
      0.00066 | 
      35 | 
      0.02193 | 
      72 | 
      Top 50  down-regulated genes in glomeruli from kidneys with diabetic nephropathy (type 2 diabetes mellitus). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SENESE_HDAC1_TARGETS_DN | 
      
       View Gene Set
       | 
      0.0006738 | 
      235 | 
      0.02208 | 
      73 | 
      Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [Gene ID=3065] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GRABARCZYK_BCL11B_TARGETS_DN | 
      
       View Gene Set
       | 
      0.0007089 | 
      51 | 
      0.02292 | 
      74 | 
      Genes down-regulated in Jurkat cells (transformed T lymphocytes) after knockdown of BCL11B [Gene ID=64919] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN | 
      
       View Gene Set
       | 
      0.0008269 | 
      599 | 
      0.02637 | 
      75 | 
      Genes down-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN | 
      
       View Gene Set
       | 
      0.0008424 | 
      56 | 
      0.02651 | 
      76 | 
      Genes down-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BLUM_RESPONSE_TO_SALIRASIB_DN | 
      
       View Gene Set
       | 
      0.0008627 | 
      332 | 
      0.0268 | 
      77 | 
      Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN | 
      
       View Gene Set
       | 
      0.0009162 | 
      296 | 
      0.02774 | 
      78 | 
      Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN | 
      
       View Gene Set
       | 
      0.0009054 | 
      317 | 
      0.02774 | 
      78 | 
      The postradiation tumor escape signature: genes down-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN | 
      
       View Gene Set
       | 
      0.0009478 | 
      155 | 
      0.02799 | 
      80 | 
      Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad YU_MYC_TARGETS_UP | 
      
       View Gene Set
       | 
      0.0009465 | 
      37 | 
      0.02799 | 
      80 | 
      Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [Gene ID=4609]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_FFA_OXYDATION | 
      
       View Gene Set
       | 
      0.001009 | 
      22 | 
      0.02942 | 
      82 | 
      Genes involved in free fatty acid oxidation; based on literature and sequence annotation resources and coverted to Affymetrix HG-U133A probe sets. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GAL_LEUKEMIC_STEM_CELL_DN | 
      
       View Gene Set
       | 
      0.001092 | 
      239 | 
      0.03146 | 
      83 | 
      
       Genes down-regulated in leukemic stem cells (LSC)
       defined as CD34+CD38- [Gene ID=947
       952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMID_BREAST_CANCER_LUMINAL_B_DN | 
      
       View Gene Set
       | 
      0.001105 | 
      549 | 
      0.03146 | 
      83 | 
      Genes down-regulated in the luminal B subtype of breast cancer. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP | 
      
       View Gene Set
       | 
      0.001181 | 
      131 | 
      0.03324 | 
      85 | 
      
       Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [Gene ID=4299
       4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HAN_SATB1_TARGETS_UP | 
      
       View Gene Set
       | 
      0.001286 | 
      303 | 
      0.03577 | 
      86 | 
      Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [Gene ID=6304] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_UP | 
      
       View Gene Set
       | 
      0.001306 | 
      64 | 
      0.03592 | 
      87 | 
      Marker genes up-regulated in the 'chromosome 7 polysomy' subclass of hepatocellular carcinoma (HCC); characterized by polysomy of chromosome 7 and by a lack of gains of chromosome 8q. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_UP | 
      
       View Gene Set
       | 
      0.00134 | 
      301 | 
      0.03642 | 
      88 | 
      Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad COWLING_MYCN_TARGETS | 
      
       View Gene Set
       | 
      0.001548 | 
      41 | 
      0.0398 | 
      89 | 
      
       Genes down-regulated by MYCN [Gene ID=4613] but not by its transactivation-defficient
       trunkated form N-Myc-delta-73.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad NUYTTEN_EZH2_TARGETS_DN | 
      
       View Gene Set
       | 
      0.001524 | 
      859 | 
      0.0398 | 
      89 | 
      Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MANALO_HYPOXIA_UP | 
      
       View Gene Set
       | 
      0.001543 | 
      197 | 
      0.0398 | 
      89 | 
      Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad AMUNDSON_GAMMA_RADIATION_RESPONSE | 
      
       View Gene Set
       | 
      0.001509 | 
      36 | 
      0.0398 | 
      89 | 
      Genes down-regulated across the entire panel of NCI-60 cell lines in response to gamma radiation. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MOOTHA_PGC | 
      
       View Gene Set
       | 
      0.001541 | 
      329 | 
      0.0398 | 
      89 | 
      Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [Gene ID=10891] off an adenoviral vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LENAOUR_DENDRITIC_CELL_MATURATION_UP | 
      
       View Gene Set
       | 
      0.001579 | 
      92 | 
      0.04018 | 
      94 | 
      Genes up-regulated during in vitro maturation of CD14+ [Gene ID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HORIUCHI_WTAP_TARGETS_UP | 
      
       View Gene Set
       | 
      0.001599 | 
      284 | 
      0.04023 | 
      95 | 
      Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CAIRO_HEPATOBLASTOMA_DN | 
      
       View Gene Set
       | 
      0.001615 | 
      264 | 
      0.04023 | 
      95 | 
      Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CAIRO_HEPATOBLASTOMA_CLASSES_DN | 
      
       View Gene Set
       | 
      0.001636 | 
      205 | 
      0.04034 | 
      97 | 
      Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad TRAYNOR_RETT_SYNDROM_UP | 
      
       View Gene Set
       | 
      0.001754 | 
      22 | 
      0.04282 | 
      98 | 
      Genes up-regulated in primary fibroblasts from Rett syndrom patients who carry mutations inactivating MECP2 [Gene ID=4204]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP | 
      
       View Gene Set
       | 
      0.001782 | 
      178 | 
      0.04305 | 
      99 | 
      Genes up-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CERVERA_SDHB_TARGETS_1_UP | 
      
       View Gene Set
       | 
      0.001831 | 
      110 | 
      0.0438 | 
      100 | 
      
       Genes turned on in Hep3B cells (hepatocellular carcinoma
       HCC) upon knockdown of SDHB [Gene ID=6390] by RNAi.
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MAINA_VHL_TARGETS_UP | 
      
       View Gene Set
       | 
      0.001891 | 
      9 | 
      0.04434 | 
      101 | 
      Genes up-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [Gene ID=7428] off a plasmid vector. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LOPEZ_MESOTHELIOMA_SURVIVAL_UP | 
      
       View Gene Set
       | 
      0.001877 | 
      11 | 
      0.04434 | 
      101 | 
      Top genes associated with favorable survival after surgery of patients with epithelioid mesothelioma. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad HOEBEKE_LYMPHOID_STEM_CELL_DN | 
      
       View Gene Set
       | 
      0.001975 | 
      83 | 
      0.04587 | 
      103 | 
      
       Genes down-regulated in the common lymphoid progenitor (CLP
       defined as CD34+CD38-CD7+ [Gene ID=947
       952
       924]) compared to a multipotent cord blood cell (defined as CD34+CD38+CD7-).
       | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad ZHAN_MULTIPLE_MYELOMA_HP_DN | 
      
       View Gene Set
       | 
      0.002035 | 
      43 | 
      0.0468 | 
      104 | 
      Top 50 down-regulated genes in cluster HP of multiple myeloma samples characterized by a hyperploid signature. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad WILCOX_PRESPONSE_TO_ROGESTERONE_UP | 
      
       View Gene Set
       | 
      0.002151 | 
      143 | 
      0.04854 | 
      105 | 
      Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad LINDGREN_BLADDER_CANCER_CLUSTER_1_DN | 
      
       View Gene Set
       | 
      0.002139 | 
      368 | 
      0.04854 | 
      105 | 
      Genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad MUELLER_METHYLATED_IN_GLIOBLASTOMA | 
      
       View Gene Set
       | 
      0.00223 | 
      42 | 
      0.04986 | 
      107 | 
      Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad NUYTTEN_NIPP1_TARGETS_UP | 
      
       View Gene Set
       | 
      0.002256 | 
      657 | 
      0.04996 | 
      108 | 
      Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN | 
      
       View Gene Set
       | 
      0.00236 | 
      86 | 
      0.04997 | 
      109 | 
      Genes down-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad BENPORATH_EED_TARGETS | 
      
       View Gene Set
       | 
      0.002296 | 
      1033 | 
      0.04997 | 
      109 | 
      Set 'Eed targets': genes identified by ChIP on chip as targets of the Polycomb protein EED [Gene ID=8726] in human embryonic stem cells. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_DN | 
      
       View Gene Set
       | 
      0.00233 | 
      18 | 
      0.04997 | 
      109 | 
      Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112]. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP | 
      
       View Gene Set
       | 
      0.002334 | 
      95 | 
      0.04997 | 
      109 | 
      Genes up-regulated in bone relapse of breast cancer. | 
      
       www.broad.mit.e...
       | 
     
     
      | Broad CROONQUIST_IL6_DEPRIVATION_DN | 
      
       View Gene Set
       | 
      0.002343 | 
      80 | 
      0.04997 | 
      109 | 
      
       Genes down-regulated in the ANBL-6 cell line (multiple myeloma
       MM) after withdrawal of IL6 [Gene ID=3569].
       | 
      
       www.broad.mit.e...
       |