Gene Set Name |
GeneSetDescription |
Value |
Gene Set Size |
Corrected Value |
Ranking |
Description |
URL |
Broad PEREZ_TP53_TARGETS |
View Gene Set
|
2.675e-13 |
1066 |
6.4e-10 |
1 |
Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [Gene ID=7157] off adenoviral vector. |
www.broad.mit.e...
|
Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN |
View Gene Set
|
5.564e-12 |
485 |
6.655e-09 |
2 |
Genes down-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. |
www.broad.mit.e...
|
Broad STEIN_ESRRA_TARGETS_UP |
View Gene Set
|
2.717e-11 |
368 |
2.167e-08 |
3 |
Genes up-regulated by ESRRA [Gene ID=2101] only. |
www.broad.mit.e...
|
Broad HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP |
View Gene Set
|
2.858e-10 |
399 |
1.709e-07 |
4 |
Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. |
www.broad.mit.e...
|
Broad RIGGI_EWING_SARCOMA_PROGENITOR_DN |
View Gene Set
|
9.254e-10 |
178 |
4.427e-07 |
5 |
Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
2321] fusion protein.
|
www.broad.mit.e...
|
Broad RIGGI_EWING_SARCOMA_PROGENITOR_UP |
View Gene Set
|
1.666e-09 |
399 |
6.64e-07 |
6 |
Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [Gene ID=2130
2321] fusion protein.
|
www.broad.mit.e...
|
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN |
View Gene Set
|
4.211e-09 |
532 |
1.439e-06 |
7 |
Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. |
www.broad.mit.e...
|
Broad PEREZ_TP63_TARGETS |
View Gene Set
|
2.455e-08 |
328 |
7.34e-06 |
8 |
Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vector. |
www.broad.mit.e...
|
Broad MOOTHA_HUMAN_MITODB_6_2002 |
View Gene Set
|
7.664e-08 |
420 |
2.037e-05 |
9 |
Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
www.broad.mit.e...
|
Broad HELLER_HDAC_TARGETS_UP |
View Gene Set
|
9.883e-08 |
268 |
2.364e-05 |
10 |
Genes up-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. |
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP |
View Gene Set
|
4.885e-07 |
422 |
9.932e-05 |
11 |
Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. |
www.broad.mit.e...
|
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 |
View Gene Set
|
4.983e-07 |
681 |
9.932e-05 |
11 |
The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
2064].
|
www.broad.mit.e...
|
Broad STEIN_ESRRA_TARGETS |
View Gene Set
|
5.634e-07 |
508 |
0.0001037 |
13 |
Genes regulated by ESRRA [Gene ID=2101] in MCF-7 cells (breast cancer). |
www.broad.mit.e...
|
Broad PEREZ_TP53_AND_TP63_TARGETS |
View Gene Set
|
6.683e-07 |
187 |
0.0001142 |
14 |
Genes up-regulated in HMEC cells (primary mammary epithelium) upon expression of both of TP53 [Gene ID=7157] and the transcriptionally active isoform of TP63 [Gene ID=8626] off adenoviral vectors. |
www.broad.mit.e...
|
Broad MOOTHA_MITOCHONDRIA |
View Gene Set
|
8.516e-07 |
433 |
0.0001358 |
15 |
Mitochondrial genes |
www.broad.mit.e...
|
Broad ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER |
View Gene Set
|
9.721e-07 |
138 |
0.0001453 |
16 |
The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. |
www.broad.mit.e...
|
Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP |
View Gene Set
|
1.071e-06 |
87 |
0.0001508 |
17 |
Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. |
www.broad.mit.e...
|
Broad BENPORATH_ES_WITH_H3K27ME3 |
View Gene Set
|
1.204e-06 |
1094 |
0.0001601 |
18 |
Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells
as identified by ChIP on chip.
|
www.broad.mit.e...
|
Broad LEE_EARLY_T_LYMPHOCYTE_UP |
View Gene Set
|
2.103e-06 |
80 |
0.0002647 |
19 |
Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. |
www.broad.mit.e...
|
Broad DELYS_THYROID_CANCER_DN |
View Gene Set
|
3.375e-06 |
213 |
0.0004037 |
20 |
Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. |
www.broad.mit.e...
|
Broad DODD_NASOPHARYNGEAL_CARCINOMA_UP |
View Gene Set
|
4.44e-06 |
1582 |
0.0004828 |
21 |
Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. |
www.broad.mit.e...
|
Broad LINDGREN_BLADDER_CANCER_CLUSTER_2B |
View Gene Set
|
4.296e-06 |
384 |
0.0004828 |
21 |
Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. |
www.broad.mit.e...
|
Broad LINDGREN_BLADDER_CANCER_CLUSTER_3_UP |
View Gene Set
|
5.906e-06 |
314 |
0.0006142 |
23 |
Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_BASAL_DN |
View Gene Set
|
6.267e-06 |
664 |
0.0006246 |
24 |
Genes down-regulated in basal subtype of breast cancer samles. |
www.broad.mit.e...
|
Broad SMITH_TERT_TARGETS_DN |
View Gene Set
|
8.384e-06 |
71 |
0.0008022 |
25 |
Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [Gene ID=7015] off a retroviral vector. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_NORMAL_LIKE_UP |
View Gene Set
|
1.071e-05 |
459 |
0.0009851 |
26 |
Genes up-regulated in the normal-like subtype of breast cancer. |
www.broad.mit.e...
|
Broad LEE_LIVER_CANCER_SURVIVAL_UP |
View Gene Set
|
1.138e-05 |
130 |
0.001009 |
27 |
Genes highly expressed in hepatocellular carcinoma with good survival. |
www.broad.mit.e...
|
Broad BENPORATH_SUZ12_TARGETS |
View Gene Set
|
1.542e-05 |
1011 |
0.001284 |
28 |
Set 'Suz12 targets': genes identified by ChIP on chip as targets of the Polycomb protein SUZ12 [Gene ID=23512] in human embryonic stem cells. |
www.broad.mit.e...
|
Broad WALLACE_PROSTATE_CANCER_RACE_UP |
View Gene Set
|
1.61e-05 |
288 |
0.001284 |
28 |
Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. |
www.broad.mit.e...
|
Broad ZHAN_MULTIPLE_MYELOMA_PR_UP |
View Gene Set
|
1.589e-05 |
43 |
0.001284 |
28 |
Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. |
www.broad.mit.e...
|
Broad RODWELL_AGING_KIDNEY_NO_BLOOD_DN |
View Gene Set
|
1.932e-05 |
119 |
0.001491 |
31 |
Genes whose expression decreases with age in normal kidney
excluding those with higher expression in blood.
|
www.broad.mit.e...
|
Broad DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP |
View Gene Set
|
2.629e-05 |
317 |
0.001965 |
32 |
Genes up-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. |
www.broad.mit.e...
|
Broad CHANG_CYCLING_GENES |
View Gene Set
|
2.764e-05 |
49 |
0.002003 |
33 |
Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. |
www.broad.mit.e...
|
Broad HUTTMANN_B_CLL_POOR_SURVIVAL_UP |
View Gene Set
|
3.057e-05 |
268 |
0.002151 |
34 |
Up-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [Gene ID=7535
952]
which are associated with poor survival.
|
www.broad.mit.e...
|
Broad ONDER_CDH1_TARGETS_2_UP |
View Gene Set
|
3.262e-05 |
249 |
0.002229 |
35 |
Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [Gene ID=999] knockdown by RNAi. |
www.broad.mit.e...
|
Broad VECCHI_GASTRIC_CANCER_EARLY_DN |
View Gene Set
|
3.556e-05 |
346 |
0.002332 |
36 |
Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. |
www.broad.mit.e...
|
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 |
View Gene Set
|
3.607e-05 |
377 |
0.002332 |
36 |
The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099
2064].
|
www.broad.mit.e...
|
Broad HOSHIDA_LIVER_CANCER_SUBCLASS_S3 |
View Gene Set
|
4.785e-05 |
266 |
0.003012 |
38 |
Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. |
www.broad.mit.e...
|
Broad WONG_MITOCHONDRIA_GENE_MODULE |
View Gene Set
|
5.146e-05 |
208 |
0.003156 |
39 |
Genes that comprise the mitochondria gene module |
www.broad.mit.e...
|
Broad CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN |
View Gene Set
|
6.124e-05 |
47 |
0.003662 |
40 |
Genes down-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones. |
www.broad.mit.e...
|
Broad ALCALAY_AML_BY_NPM1_LOCALIZATION_DN |
View Gene Set
|
6.761e-05 |
179 |
0.003945 |
41 |
Genes changed in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [Gene ID=4869]: cytoplasmic vs. nucleolar. |
www.broad.mit.e...
|
Broad CASTELLANO_NRAS_TARGETS_UP |
View Gene Set
|
9.081e-05 |
59 |
0.005051 |
42 |
Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [Gene ID=4893] knockout mice. |
www.broad.mit.e...
|
Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP |
View Gene Set
|
8.984e-05 |
135 |
0.005051 |
42 |
Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation
high levels of serum AFP [Gene ID=174]
and chromosomal instability.
|
www.broad.mit.e...
|
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP |
View Gene Set
|
9.845e-05 |
180 |
0.005352 |
44 |
Genes up-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. |
www.broad.mit.e...
|
Broad LANDIS_ERBB2_BREAST_TUMORS_324_DN |
View Gene Set
|
0.0001025 |
137 |
0.005451 |
45 |
The 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [Gene ID=2064]. |
www.broad.mit.e...
|
Broad BROWNE_HCMV_INFECTION_48HR_UP |
View Gene Set
|
0.0001264 |
175 |
0.006571 |
46 |
Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 48 h time point that were not up-regulated at the previous time point
24 h.
|
www.broad.mit.e...
|
Broad BERENJENO_TRANSFORMED_BY_RHOA_DN |
View Gene Set
|
0.0001521 |
353 |
0.007741 |
47 |
Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [Gene ID=387] off plasmid vector. |
www.broad.mit.e...
|
Broad CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN |
View Gene Set
|
0.0001801 |
154 |
0.008977 |
48 |
Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation
high levels of serum AFP [Gene ID=174]
and chromosomal instability.
|
www.broad.mit.e...
|
Broad BLALOCK_ALZHEIMERS_DISEASE_DN |
View Gene Set
|
0.0002042 |
1209 |
0.009968 |
49 |
Genes down-regulated in brain from patients with Alzheimer's disease. |
www.broad.mit.e...
|
Broad TIEN_INTESTINE_PROBIOTICS_24HR_UP |
View Gene Set
|
0.0002133 |
537 |
0.0102 |
50 |
Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. |
www.broad.mit.e...
|
Broad BILD_E2F3_ONCOGENIC_SIGNATURE |
View Gene Set
|
0.000232 |
222 |
0.01087 |
51 |
Genes selected in supervised analyses to discriminate cells expressing E2F3 [Gene ID=1871] from control cells expressing GFP. |
www.broad.mit.e...
|
Broad CHUNG_BLISTER_CYTOTOXICITY_UP |
View Gene Set
|
0.0002408 |
126 |
0.01087 |
51 |
Genes changed in blister cells from patients with adverse drug reactions (ADR). |
www.broad.mit.e...
|
Broad POOLA_INVASIVE_BREAST_CANCER_UP |
View Gene Set
|
0.0002375 |
278 |
0.01087 |
51 |
Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). |
www.broad.mit.e...
|
Broad KOYAMA_SEMA3B_TARGETS_DN |
View Gene Set
|
0.0002884 |
286 |
0.01277 |
54 |
Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [Gene ID=7869]. |
www.broad.mit.e...
|
Broad BENPORATH_PRC2_TARGETS |
View Gene Set
|
0.000339 |
636 |
0.01448 |
55 |
Set 'PRC2 targets': Polycomb Repression Complex 2 (PRC) targets; identified by ChIP on chip on human embryonic stem cells as genes that: posess the trimethylated H3K27 mark in their promoters and are bound by SUZ12 [Gene ID=23512] and EED [Gene ID=8726] Polycomb proteins. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_LUMINAL_B_UP |
View Gene Set
|
0.0003371 |
162 |
0.01448 |
55 |
Genes up-regulated in the luminal B subtype of breast cancer. |
www.broad.mit.e...
|
Broad MOOTHA_TCA |
View Gene Set
|
0.0003763 |
15 |
0.01579 |
57 |
Tricarboxylic acid related genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
www.broad.mit.e...
|
Broad MOOTHA_VOXPHOS |
View Gene Set
|
0.0004092 |
82 |
0.01688 |
58 |
Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
www.broad.mit.e...
|
Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP |
View Gene Set
|
0.0004709 |
75 |
0.01886 |
59 |
Up-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [Gene ID=4297
4299] or AF4-MLL fusion proteins alone
and those expressing both fusion proteins.
|
www.broad.mit.e...
|
Broad RICKMAN_HEAD_AND_NECK_CANCER_A |
View Gene Set
|
0.000473 |
91 |
0.01886 |
59 |
Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). |
www.broad.mit.e...
|
Broad KIM_LRRC3B_TARGETS |
View Gene Set
|
0.0005068 |
30 |
0.01987 |
61 |
Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135]. |
www.broad.mit.e...
|
Broad ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN |
View Gene Set
|
0.0005166 |
258 |
0.01993 |
62 |
Genes down-regulated in macrophages by P.gingivalis FimA pathogen. |
www.broad.mit.e...
|
Broad CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP |
View Gene Set
|
0.0005257 |
38 |
0.01996 |
63 |
Genes up-regulated in secondary APL (acute promyelocytic leukemia) compared to the de novo tumors. |
www.broad.mit.e...
|
Broad SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP |
View Gene Set
|
0.0005511 |
143 |
0.0206 |
64 |
Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. |
www.broad.mit.e...
|
Broad LIU_PROSTATE_CANCER_DN |
View Gene Set
|
0.000573 |
446 |
0.02077 |
65 |
Genes down-regulated in prostate cancer samples. |
www.broad.mit.e...
|
Broad DOUGLAS_BMI1_TARGETS_UP |
View Gene Set
|
0.0005692 |
497 |
0.02077 |
65 |
Genes up-regulated in A4573 cells (Ewing's sarcoma
ESFT) after knockdown of BMI1 [Gene ID=648] by RNAi.
|
www.broad.mit.e...
|
Broad NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN |
View Gene Set
|
0.000598 |
73 |
0.02135 |
67 |
Top 100 probe sets contrubuting to the negative side of the 1st principal component; predominantly associated with synovial sarcoma and myxoid/round cell liposarcoma samples. |
www.broad.mit.e...
|
Broad HELLER_SILENCED_BY_METHYLATION_UP |
View Gene Set
|
0.0006183 |
247 |
0.0215 |
68 |
Genes up-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. |
www.broad.mit.e...
|
Broad CHANDRAN_METASTASIS_DN |
View Gene Set
|
0.0006201 |
90 |
0.0215 |
68 |
Genes down-regulated in metastatic tumors from the whole panel of patients with prostate cancer. |
www.broad.mit.e...
|
Broad MONTERO_THYROID_CANCER_POOR_SURVIVAL_UP |
View Gene Set
|
0.0006387 |
10 |
0.02183 |
70 |
Up-regulated genes predicting poor survival of patients with thyroid carcinoma. |
www.broad.mit.e...
|
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G3_DN |
View Gene Set
|
0.0006499 |
51 |
0.02189 |
71 |
Down-regulated genes in hepatocellular carcinoma (HCC) subclass G3
defined by unsupervised clustering.
|
www.broad.mit.e...
|
Broad BAELDE_DIABETIC_NEPHROPATHY_DN |
View Gene Set
|
0.00066 |
35 |
0.02193 |
72 |
Top 50 down-regulated genes in glomeruli from kidneys with diabetic nephropathy (type 2 diabetes mellitus). |
www.broad.mit.e...
|
Broad SENESE_HDAC1_TARGETS_DN |
View Gene Set
|
0.0006738 |
235 |
0.02208 |
73 |
Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [Gene ID=3065] by RNAi. |
www.broad.mit.e...
|
Broad GRABARCZYK_BCL11B_TARGETS_DN |
View Gene Set
|
0.0007089 |
51 |
0.02292 |
74 |
Genes down-regulated in Jurkat cells (transformed T lymphocytes) after knockdown of BCL11B [Gene ID=64919] by RNAi. |
www.broad.mit.e...
|
Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN |
View Gene Set
|
0.0008269 |
599 |
0.02637 |
75 |
Genes down-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. |
www.broad.mit.e...
|
Broad KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN |
View Gene Set
|
0.0008424 |
56 |
0.02651 |
76 |
Genes down-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes. |
www.broad.mit.e...
|
Broad BLUM_RESPONSE_TO_SALIRASIB_DN |
View Gene Set
|
0.0008627 |
332 |
0.0268 |
77 |
Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. |
www.broad.mit.e...
|
Broad SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN |
View Gene Set
|
0.0009162 |
296 |
0.02774 |
78 |
Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue. |
www.broad.mit.e...
|
Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN |
View Gene Set
|
0.0009054 |
317 |
0.02774 |
78 |
The postradiation tumor escape signature: genes down-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. |
www.broad.mit.e...
|
Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN |
View Gene Set
|
0.0009478 |
155 |
0.02799 |
80 |
Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. |
www.broad.mit.e...
|
Broad YU_MYC_TARGETS_UP |
View Gene Set
|
0.0009465 |
37 |
0.02799 |
80 |
Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [Gene ID=4609]. |
www.broad.mit.e...
|
Broad MOOTHA_FFA_OXYDATION |
View Gene Set
|
0.001009 |
22 |
0.02942 |
82 |
Genes involved in free fatty acid oxidation; based on literature and sequence annotation resources and coverted to Affymetrix HG-U133A probe sets. |
www.broad.mit.e...
|
Broad GAL_LEUKEMIC_STEM_CELL_DN |
View Gene Set
|
0.001092 |
239 |
0.03146 |
83 |
Genes down-regulated in leukemic stem cells (LSC)
defined as CD34+CD38- [Gene ID=947
952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells.
|
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_LUMINAL_B_DN |
View Gene Set
|
0.001105 |
549 |
0.03146 |
83 |
Genes down-regulated in the luminal B subtype of breast cancer. |
www.broad.mit.e...
|
Broad GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP |
View Gene Set
|
0.001181 |
131 |
0.03324 |
85 |
Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [Gene ID=4299
4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins.
|
www.broad.mit.e...
|
Broad HAN_SATB1_TARGETS_UP |
View Gene Set
|
0.001286 |
303 |
0.03577 |
86 |
Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [Gene ID=6304] by RNAi. |
www.broad.mit.e...
|
Broad CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_UP |
View Gene Set
|
0.001306 |
64 |
0.03592 |
87 |
Marker genes up-regulated in the 'chromosome 7 polysomy' subclass of hepatocellular carcinoma (HCC); characterized by polysomy of chromosome 7 and by a lack of gains of chromosome 8q. |
www.broad.mit.e...
|
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_UP |
View Gene Set
|
0.00134 |
301 |
0.03642 |
88 |
Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. |
www.broad.mit.e...
|
Broad COWLING_MYCN_TARGETS |
View Gene Set
|
0.001548 |
41 |
0.0398 |
89 |
Genes down-regulated by MYCN [Gene ID=4613] but not by its transactivation-defficient
trunkated form N-Myc-delta-73.
|
www.broad.mit.e...
|
Broad NUYTTEN_EZH2_TARGETS_DN |
View Gene Set
|
0.001524 |
859 |
0.0398 |
89 |
Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. |
www.broad.mit.e...
|
Broad MANALO_HYPOXIA_UP |
View Gene Set
|
0.001543 |
197 |
0.0398 |
89 |
Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. |
www.broad.mit.e...
|
Broad AMUNDSON_GAMMA_RADIATION_RESPONSE |
View Gene Set
|
0.001509 |
36 |
0.0398 |
89 |
Genes down-regulated across the entire panel of NCI-60 cell lines in response to gamma radiation. |
www.broad.mit.e...
|
Broad MOOTHA_PGC |
View Gene Set
|
0.001541 |
329 |
0.0398 |
89 |
Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [Gene ID=10891] off an adenoviral vector. |
www.broad.mit.e...
|
Broad LENAOUR_DENDRITIC_CELL_MATURATION_UP |
View Gene Set
|
0.001579 |
92 |
0.04018 |
94 |
Genes up-regulated during in vitro maturation of CD14+ [Gene ID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14). |
www.broad.mit.e...
|
Broad HORIUCHI_WTAP_TARGETS_UP |
View Gene Set
|
0.001599 |
284 |
0.04023 |
95 |
Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. |
www.broad.mit.e...
|
Broad CAIRO_HEPATOBLASTOMA_DN |
View Gene Set
|
0.001615 |
264 |
0.04023 |
95 |
Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. |
www.broad.mit.e...
|
Broad CAIRO_HEPATOBLASTOMA_CLASSES_DN |
View Gene Set
|
0.001636 |
205 |
0.04034 |
97 |
Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). |
www.broad.mit.e...
|
Broad TRAYNOR_RETT_SYNDROM_UP |
View Gene Set
|
0.001754 |
22 |
0.04282 |
98 |
Genes up-regulated in primary fibroblasts from Rett syndrom patients who carry mutations inactivating MECP2 [Gene ID=4204]. |
www.broad.mit.e...
|
Broad ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP |
View Gene Set
|
0.001782 |
178 |
0.04305 |
99 |
Genes up-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562]. |
www.broad.mit.e...
|
Broad CERVERA_SDHB_TARGETS_1_UP |
View Gene Set
|
0.001831 |
110 |
0.0438 |
100 |
Genes turned on in Hep3B cells (hepatocellular carcinoma
HCC) upon knockdown of SDHB [Gene ID=6390] by RNAi.
|
www.broad.mit.e...
|
Broad MAINA_VHL_TARGETS_UP |
View Gene Set
|
0.001891 |
9 |
0.04434 |
101 |
Genes up-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [Gene ID=7428] off a plasmid vector. |
www.broad.mit.e...
|
Broad LOPEZ_MESOTHELIOMA_SURVIVAL_UP |
View Gene Set
|
0.001877 |
11 |
0.04434 |
101 |
Top genes associated with favorable survival after surgery of patients with epithelioid mesothelioma. |
www.broad.mit.e...
|
Broad HOEBEKE_LYMPHOID_STEM_CELL_DN |
View Gene Set
|
0.001975 |
83 |
0.04587 |
103 |
Genes down-regulated in the common lymphoid progenitor (CLP
defined as CD34+CD38-CD7+ [Gene ID=947
952
924]) compared to a multipotent cord blood cell (defined as CD34+CD38+CD7-).
|
www.broad.mit.e...
|
Broad ZHAN_MULTIPLE_MYELOMA_HP_DN |
View Gene Set
|
0.002035 |
43 |
0.0468 |
104 |
Top 50 down-regulated genes in cluster HP of multiple myeloma samples characterized by a hyperploid signature. |
www.broad.mit.e...
|
Broad WILCOX_PRESPONSE_TO_ROGESTERONE_UP |
View Gene Set
|
0.002151 |
143 |
0.04854 |
105 |
Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. |
www.broad.mit.e...
|
Broad LINDGREN_BLADDER_CANCER_CLUSTER_1_DN |
View Gene Set
|
0.002139 |
368 |
0.04854 |
105 |
Genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. |
www.broad.mit.e...
|
Broad MUELLER_METHYLATED_IN_GLIOBLASTOMA |
View Gene Set
|
0.00223 |
42 |
0.04986 |
107 |
Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment. |
www.broad.mit.e...
|
Broad NUYTTEN_NIPP1_TARGETS_UP |
View Gene Set
|
0.002256 |
657 |
0.04996 |
108 |
Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. |
www.broad.mit.e...
|
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN |
View Gene Set
|
0.00236 |
86 |
0.04997 |
109 |
Genes down-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. |
www.broad.mit.e...
|
Broad BENPORATH_EED_TARGETS |
View Gene Set
|
0.002296 |
1033 |
0.04997 |
109 |
Set 'Eed targets': genes identified by ChIP on chip as targets of the Polycomb protein EED [Gene ID=8726] in human embryonic stem cells. |
www.broad.mit.e...
|
Broad CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_DN |
View Gene Set
|
0.00233 |
18 |
0.04997 |
109 |
Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112]. |
www.broad.mit.e...
|
Broad SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP |
View Gene Set
|
0.002334 |
95 |
0.04997 |
109 |
Genes up-regulated in bone relapse of breast cancer. |
www.broad.mit.e...
|
Broad CROONQUIST_IL6_DEPRIVATION_DN |
View Gene Set
|
0.002343 |
80 |
0.04997 |
109 |
Genes down-regulated in the ANBL-6 cell line (multiple myeloma
MM) after withdrawal of IL6 [Gene ID=3569].
|
www.broad.mit.e...
|