Test Results

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Gene Set Null Sphingosine 1-phosphate (S1P) pathway

featureNamesProbeIDlogFCAveExprtP.Valueadj.P.ValBSYMBOLGENENAMEENSEMBL.HsaOMIMENTREZIDGenBank
10000HSAP00P00000436180.72286.5742.2780.036990.2102-4.219AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)ENSG0000011702061122310000NM_005465
1003HSAP00P00003264780.59947.4041.8260.086740.3271-4.976CDH5cadherin 5, type 2 (vascular endothelium)ENSG000001797766011201003NM_001795
10603HSAP00P00001688760.94126.232.710.015590.1298-3.422SH2B2SH2B adaptor protein 2ENSG0000025741960530010603NM_020979
10672HSAP00P0000352539-1.2597.274-4.2230.00066430.01839-0.3923GNA13guanine nucleotide binding protein (G protein), alpha 13ENSG0000012006360440610672NM_006572
1432HSAP00P0000141708-2.2296.41-5.5474.641e-050.0034092.206MAPK14mitogen-activated protein kinase 14ENSG000001120626002891432NM_001315
1445HSAP00P0000308712-1.5957.381-4.3980.00046270.01458-0.03983CSKc-src tyrosine kinaseENSG000001036531240951445NM_004383
1796HSAP00P00000538940.63326.9272.3890.029710.1866-4.019DOK1docking protein 1, 62kDa (downstream of tyrosine kinase 1)ENSG000001153256029191796AF035299
1950HSAP00P0000108425-1.325.284-3.7160.0019170.03642-1.421EGFepidermal growth factorENSG00000138798131530, 6117181950NM_001963
2002HSAP00P0000424246-0.76637.91-2.7210.015250.1282-3.401ELK1ELK1, member of ETS oncogene familyENSG000001267673110402002AK093966
207HSAP00P0000298189-1.5979.721-6.9383.59e-060.00071164.692AKT1v-akt murine thymoma viral oncogene homolog 1ENSG00000142208114480, 114500, 164730, 167000, 176920, 181500, 604370207NM_005163
2241HSAP00P00001223890.9194.9212.2630.038130.2136-4.246FERfer (fps/fes related) tyrosine kinaseENSG000001514221769422241NM_005246
2268HSAP00P00000088400.54217.8141.3170.20680.4977-5.694FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologENSG000000009381649402268NM_005248
2321HSAP00P0000278549-0.67124.149-2.2020.042910.2278-4.353FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)ENSG000001027551650702321S77814
2353HSAP00P00002933290.73634.5572.7730.013690.1204-3.3FOSFBJ murine osteosarcoma viral oncogene homologENSG000001703451648102353NM_005252
25HSAP00P0000206625-1.5997.555-4.8180.00019630.0084770.7973ABL1c-abl oncogene 1, non-receptor tyrosine kinaseENSG0000009700718998025NM_007313
2767HSAP00P0000367444-1.488.926-1.8920.076910.3076-4.872GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)ENSG000000882561393132767BC001528
2768HSAP00P0000156698-1.4747.432-3.9830.0010950.02544-0.8787GNA12guanine nucleotide binding protein (G protein) alpha 12ENSG000001465356043942768BC009457
2770HSAP00P00001652952.3553.9472.6120.019030.1453-3.607GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSG000001279551393102770NM_002069
2773HSAP00P0000021232-0.73877.56-1.8820.078350.3106-4.888GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3ENSG000000651351393702773NM_006496
2776HSAP00P00001977490.84756.012.3390.032830.197-4.11GNAQguanine nucleotide binding protein (G protein), q polypeptideENSG000001560526009982776NM_002072
2781HSAP00P0000412602-1.1327.801-3.6840.002050.03795-1.486GNAZguanine nucleotide binding protein (G protein), alpha z polypeptideENSG000001282661391602781NM_002073
2885HSAP00P0000354354-0.77537.577-2.4160.028210.1814-3.971GRB2growth factor receptor-bound protein 2ENSG000001778851083552885NM_002086
2886HSAP00P0000344234-1.1175.137-2.5550.021350.1551-3.714GRB7growth factor receptor-bound protein 7ENSG000001417386015222886NM_005310
2887HSAP00P0000162325-2.9577.988-11.583.967e-091.276e-0511.03GRB10growth factor receptor-bound protein 10ENSG000001060706015232887D86962
29907HSAP00P0000241413-1.6196.853-4.9840.00014060.0068681.123SNX15sorting nexin 15ENSG0000011002560596429907NM_013306
3055HSAP00P00003981360.69516.5021.9160.073710.3011-4.834HCKhemopoietic cell kinaseENSG000001013361423703055NM_002110
3091HSAP00P0000290665-1.3938.207-4.520.00036010.012460.2047HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)ENSG000001006446033483091NM_001530
3265HSAP00P0000228139-1.829.408-3.2380.0052190.06759-2.385HRASv-Ha-ras Harvey rat sarcoma viral oncogene homologENSG00000174775109800, 188470, 190020, 2180403265NM_176795
3685HSAP00P0000065312-0.81219.235-2.7670.013880.1214-3.313ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)ENSG000001384481932103685NM_002210
3717HSAP00P00001919410.85336.7292.1210.050120.2468-4.493JAK2Janus kinase 2ENSG00000096968147796, 187950, 254450, 263300, 600880, 6016263717NM_004972
387HSAP00P0000080645-2.33111.58-4.4930.00038070.012890.1503RHOAras homolog gene family, member AENSG00000067560165390387BC000946
4067HSAP00P0000182534-0.62327.912-2.2270.040820.2218-4.308LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologENSG000002540871651204067BC068551
427HSAP00P0000178340-2.5719.606-7.0682.867e-060.00062494.908ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1ENSG00000104763228000, 613468427NM_004315
4363HSAP00P0000318799-1.7766.481-3.6410.0022430.04015-1.573ABCC1ATP-binding cassette, sub-family C (CFTR/MRP), member 1ENSG000001032221583434363BC001636
4609HSAP00P0000187956-4.04510.73-14.761.181e-102.478e-0614.02MYCv-myc myelocytomatosis viral oncogene homolog (avian)ENSG00000136997113970, 1900804609X66258
4690HSAP00P0000090809-1.118.177-3.2860.0047190.06349-2.289NCK1NCK adaptor protein 1ENSG000001580926005084690NM_006153
4790HSAP00P0000107725-3.169.437-13.017.483e-105.588e-0612.48NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1ENSG000001093201640114790NM_003998
4792HSAP00P0000287985-1.4729.952-5.9492.157e-050.0021112.953NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaENSG00000100906164008, 6121324792BC002601
5058HSAP00P0000246187-0.99666.48-2.2230.041160.2227-4.316PAK1p21 protein (Cdc42/Rac)-activated kinase 1ENSG000001492696025905058NM_002576
5074HSAP00P00002687640.70935.3091.5130.150.4273-5.437PAWRPRKC, apoptosis, WT1, regulatorENSG000001774256019365074NM_002583
51060HSAP00P0000015016-2.2037.103-4.4170.0004450.01426-0.001944TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)ENSG0000011786260944851060NM_015913
5154HSAP00P00004403390.66619.8951.9490.069280.2917-4.78PDGFAplatelet-derived growth factor alpha polypeptideENSG000001974611734305154NM_033023
5159HSAP00P00001281710.84055.2972.2720.037450.2116-4.23PDGFRBplatelet-derived growth factor receptor, beta polypeptideENSG00000113721131440, 1734105159BC032224
5290HSAP00P00000945670.64793.4761.9480.069430.292-4.782PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptideENSG00000121879114480, 114500, 114550, 137215, 162900, 167000, 171834, 182000, 211980, 6043705290NM_006218
5295HSAP00P0000119062-2.5617.635-5.8472.614e-050.0023882.765PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)ENSG000001456751718335295NM_181524
53637HSAP00P00003716360.9657.1322.6320.018270.1421-3.569S1PR5sphingosine-1-phosphate receptor 5ENSG0000018073960514653637AF331840
5580HSAP00P0000082792-1.9977.238-4.6780.00026070.010170.5202PRKCDprotein kinase C, deltaENSG000001639321769775580NM_006254
5594HSAP00P0000412127-1.9827.249-5.2877.696e-050.0047071.712MAPK1mitogen-activated protein kinase 1ENSG000001000301769485594NM_002745
5595HSAP00P0000322532-0.83047.733-2.4420.026770.1762-3.923MAPK3mitogen-activated protein kinase 3ENSG000001028826017955595BC000205
5604HSAP00P0000307038-1.1919.719-3.7850.0016590.03326-1.281MAP2K1mitogen-activated protein kinase kinase 1ENSG00000169032115150, 1768725604NM_002755
5610HSAP00P0000049222-1.3328.477-4.6160.00029570.0110.3972EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 2ENSG000000553321768715610NM_002759
56848HSAP00P0000386908-1.2627.827-2.5730.020560.1519-3.68SPHK2sphingosine kinase 2ENSG0000006317660709256848NM_020126
572HSAP00P0000240754-1.3758.988-3.3430.0041930.05903-2.176BADBCL2-associated agonist of cell deathENSG00000002330603167572NM_004322
5728HSAP00P0000219804-0.72295.468-1.880.078710.3113-4.892PTENphosphatase and tensin homologENSG00000171862137800, 153480, 155600, 158350, 174900, 176807, 176920, 188470, 275355, 276950, 601728, 605309, 607174, 608089, 612242, 6130285728NM_000314
5743HSAP00P00000359470.89543.9952.20.043020.2281-4.356PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)ENSG000000737566002625743NM_000963
5771HSAP00P00003600020.40144.0521.1360.27290.5676-5.904PTPN2protein tyrosine phosphatase, non-receptor type 2ENSG000001753541768875771NM_002828
5781HSAP00P0000272912-3.0518.069-5.2388.484e-050.005011.617PTPN11protein tyrosine phosphatase, non-receptor type 11ENSG00000179295151100, 156250, 163950, 163955, 176876, 6077855781BC030949
5795HSAP00P00002367450.8188.7682.6130.018970.1451-3.604PTPRJprotein tyrosine phosphatase, receptor type, JENSG00000149177114500, 6009255795NM_002843
581HSAP00P0000387186-0.67888.209-2.3690.030930.1908-4.056BAXBCL2-associated X proteinENSG00000087088600040581NM_138764
5879HSAP00P0000157474-1.5038.669-5.3636.631e-050.0042731.857RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)ENSG000001362386020485879BC050687
5894HSAP00P0000074884-1.9278.262-6.5616.997e-060.001054.046RAF1v-raf-1 murine leukemia viral oncogene homolog 1ENSG00000132155164760, 611553, 6115545894NM_002880
5921HSAP00P0000121262-1.0126.451-1.9970.063410.2786-4.702RASA1RAS p21 protein activator (GTPase activating protein) 1ENSG00000145715139150, 605462, 608354, 6083555921NM_022650
5925HSAP00P0000280585-1.2767.01-3.4650.0032430.05045-1.929RB1retinoblastoma 1ENSG00000139687109800, 180200, 182280, 259500, 6140415925BC040540
596HSAP00P00003637480.80555.4642.6720.016860.1357-3.494BCL2B-cell CLL/lymphoma 2ENSG00000171791151430596NM_000633
5970HSAP00P00002420520.66379.052.440.026890.1766-3.927RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)ENSG000001730391640145970L19067
637HSAP00P0000410508-2.0776.011-4.3330.00052840.01584-0.1694BIDBH3 interacting domain death agonistENSG00000015475601997637NM_001196
640HSAP00P00001775840.80217.9951.9930.063780.2794-4.707BLKB lymphoid tyrosine kinaseENSG00000136573191305, 613375640S76617
6416HSAP00P0000337886-1.3337.188-3.1350.0064770.07705-2.591MAP2K4mitogen-activated protein kinase kinase 4ENSG000000655596013356416NM_003010
6464HSAP00P0000028401-1.6159.216-4.6370.00028320.010690.4392SHC1SHC (Src homology 2 domain containing) transforming protein 1ENSG000001606916005606464NM_003029
6503HSAP00P00001883170.87227.7252.7680.013840.1212-3.31SLASrc-like-adaptorENSG000001559266010996503NM_006748
6609HSAP00P0000231020-0.94056.53-3.0320.0080250.08764-2.795SMPD1sphingomyelin phosphodiesterase 1, acid lysosomalENSG00000166311257200, 607608, 6076166609X59960
6654HSAP00P00000495750.54523.7811.5030.15260.4308-5.451SOS1son of sevenless homolog 1 (Drosophila)ENSG00000115904135300, 163955, 182530, 6107336654NM_005633
6714HSAP00P0000399843-0.82545.907-2.7180.015350.1287-3.407SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)ENSG000001971221900906714BC051270
6772HSAP00P00000658540.73354.3191.8320.085950.3255-4.968STAT1signal transducer and activator of transcription 1, 91kDaENSG00000115415209950, 600555, 613796, 6141626772NM_007315
6774HSAP00P0000345957-1.3857.117-2.8620.01140.108-3.127STAT3signal transducer and activator of transcription 3 (acute-phase response factor)ENSG00000168610102582, 1470606774NM_139276
6777HSAP00P0000345924-1.1967.476-4.9620.00014680.0070541.081STAT5Bsignal transducer and activator of transcription 5BENSG00000173757245590, 6042606777NM_012448
7124HSAP00P00001388390.82487.6922.1410.048210.2419-4.458TNFtumor necrosis factorENSG00000228978, ENSG00000232810, ENSG00000204490, ENSG00000228321, ENSG00000228849, ENSG00000230108, ENSG00000206439, ENSG00000223952157300, 191160, 248310, 600807, 6111627124NM_000594
7132HSAP00P0000255474-2.6488.688-6.4378.76e-060.0012043.828TNFRSF1Atumor necrosis factor receptor superfamily, member 1AENSG00000067182142680, 1911907132NM_001065
7186HSAP00P0000209096-0.6147.352-2.1610.046380.2371-4.423TRAF2TNF receptor-associated factor 2ENSG000001271916018957186BX538160
7410HSAP00P0000207863-2.6267.343-6.9323.627e-060.00071564.682VAV2vav 2 guanine nucleotide exchange factorENSG000001602936004287410NM_003371
7422HSAP00P0000144166-1.9837.639-3.6690.0021140.03869-1.516VEGFAvascular endothelial growth factor AENSG00000112715125853, 192240, 6039337422AF022375
7525HSAP00P0000358774-0.65067.606-1.9630.06750.2877-4.757YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1ENSG000001761051648807525NM_005433
81537HSAP00P00002908390.41083.6121.9230.072740.299-4.823SGPP1sphingosine-1-phosphate phosphatase 1ENSG0000012682161282681537NM_030791
83939HSAP00P0000092232-2.3137.128-6.4838.059e-060.0011443.909EIF2Aeukaryotic translation initiation factor 2A, 65kDaENSG0000014489560923483939AF172818
8439HSAP00P0000182772-1.6217.594-3.5780.0025580.04356-1.7NSMAFneutral sphingomyelinase (N-SMase) activation associated factorENSG000000356816030438439NM_003580
8440HSAP00P0000057506-0.72957.022-1.8130.088850.3311-4.997NCK2NCK adaptor protein 2ENSG000000710516049308440NM_003581
8567HSAP00P0000236348-1.5736.662-2.6050.019280.1465-3.62MADDMAP-kinase activating death domainENSG000001105146035848567NM_003682
8575HSAP00P0000064488-1.1116.568-2.7220.015220.1281-3.399PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activatorENSG00000180228603424, 6120678575BC009470
8717HSAP00P0000326905-0.44458.765-1.6720.11420.3746-5.211TRADDTNFRSF1A-associated via death domainENSG000001028716035008717NM_003789
8738HSAP00P0000269584-1.3458.846-5.1470.00010160.0056021.441CRADDCASP2 and RIPK1 domain containing adaptor with death domainENSG000001693726034548738NM_003805
8772HSAP00P0000244350-2.238.231-5.1460.00010180.0056111.439FADDFas (TNFRSF6)-associated via death domainENSG00000168040602457, 6137598772NM_003824
8879HSAP00P0000217637-2.4197.608-7.1262.596e-060.00058875.004SGPL1sphingosine-1-phosphate lyase 1ENSG000001662246037298879AB033078
9131HSAP00P0000432019-0.90369.729-2.810.012710.1152-3.23AIFM1apoptosis-inducing factor, mitochondrion-associated, 1ENSG00000156709300169, 3008169131NM_004208
9294HSAP00P00003713280.6179.2132.2920.036030.2075-4.195S1PR2sphingosine-1-phosphate receptor 2ENSG000001758986051119294NM_004230
9351HSAP00P0000315369-0.97617.398-3.6810.0020620.03806-1.492SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2ENSG000000650546065539351BC069014
9368HSAP00P0000353863-0.9018.774-1.8590.081810.3174-4.925SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1ENSG00000109062604990, 6122879368NM_004252
9448HSAP00P0000057195-2.316.311-7.9976.098e-070.00024426.39MAP4K4mitogen-activated protein kinase kinase kinase kinase 4ENSG000000710546046669448AB014587
9530HSAP00P0000181082-1.0446.899-2.190.043870.2305-4.373BAG4BCL2-associated athanogene 4ENSG000001567356038849530BC038505
9630HSAP00P00001977290.44868.271.6740.11380.374-5.208GNA14guanine nucleotide binding protein (G protein), alpha 14ENSG000001560496043979630NM_004297
998HSAP00P0000006791-2.2017.844-6.2361.264e-050.0015043.473CDC42cell division cycle 42 (GTP binding protein, 25kDa)ENSG00000070831116952998BC018266