Results

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Go to: Gene Set Collection: KEGG
Go to: Gene Set Collection: GO
Go to: Gene Set Collection: Broad.c2.CGP
Go to: Gene Set Collection: Broad.c2.CP
Go to: Gene Set Collection: Broad.c2.CP.BIOCARTA
Go to: Gene Set Collection: Broad.c2.CP.KEGG
Go to: Gene Set Collection: Broad.c2.CP.REACTOME
Go to: Gene Set Collection: Broad.c3.MIR
Go to: Gene Set Collection: Broad.c3.TFT
Go to: Gene Set Collection: Broad.c4.CGN
Go to: Gene Set Collection: Broad.c4.CM
Go to: Gene Set Collection: Broad.c5.BP
Go to: Gene Set Collection: Broad.c5.CC
Go to: Gene Set Collection: Broad.c5.MF
Go to: Gene Set Collection: PMID
Go to: Gene Set Collection: ChromosomalTiles5Mb
Go to: Gene Set Collection: Prosite
Go to: Gene Set Collection: Enzyme
Go to: Gene Set Collection: ppi.BIND
Go to: Gene Set Collection: ppi.BioGRID
Go to: Gene Set Collection: ppi.HPRD
Go to: Gene Set Collection: ppi.anyDB
Go to: Gene Set Collection: pathwayCommons.cell-map
Go to: Gene Set Collection: pathwayCommons.humancyc
Go to: Gene Set Collection: pathwayCommons.nci-nature
Go to: Gene Set Collection: pathwayCommons.reactome
Go to: Gene Set Collection: miranda.targets
Go to: Gene Set Collection: mirbase.targets
Go to: Gene Set Collection: mirtarget2.targets
Go to: Gene Set Collection: pictar.targets
Go to: Gene Set Collection: tarbase.targets
Go to: Gene Set Collection: targetscan.targets
Go to: Gene Set Collection: miRNAtargetIntersection
Go to: Gene Set Collection: miRNAtargetUnion
Go to: Gene Set Collection: hprdBatch.UP
Go to: Gene Set Collection: hprdBatch.DOWN
Go to: Gene Set Collection: hprdBatch.DIFFERENT
Go to: Gene Set Collection: hprdManual.UP
Go to: Gene Set Collection: hprdManual.DIFFERENT
Go to: Gene Set Collection: tfbsK3Z3

AFA results for: TSAvsControl

Click on the heading for any column to sort by that column.

Gene Set Collection: KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
KEGG 03010 View Gene Set 1.053e-25 88 2.252e-23 1 Ribosome www.genome.jp/d...
KEGG 01100 View Gene Set 3.734e-25 1120 3.995e-23 2 Metabolic pathways www.genome.jp/d...
KEGG 04141 View Gene Set 1.129e-21 167 8.05e-20 3 Protein processing in endoplasmic reticulum www.genome.jp/d...
KEGG 03040 View Gene Set 4.301e-20 128 2.301e-18 4 Spliceosome www.genome.jp/d...
KEGG 04110 View Gene Set 1.503e-15 128 6.431e-14 5 Cell cycle www.genome.jp/d...
KEGG 00190 View Gene Set 3.557e-12 134 1.269e-10 6 Oxidative phosphorylation www.genome.jp/d...
KEGG 00240 View Gene Set 1.265e-10 99 3.868e-09 7 Pyrimidine metabolism www.genome.jp/d...
KEGG 04120 View Gene Set 1.785e-10 139 4.776e-09 8 Ubiquitin mediated proteolysis www.genome.jp/d...
KEGG 05016 View Gene Set 2.351e-10 184 5.591e-09 9 Huntington's disease www.genome.jp/d...
KEGG 03018 View Gene Set 3.206e-10 59 6.861e-09 10 RNA degradation www.genome.jp/d...
KEGG 05012 View Gene Set 3.986e-09 132 7.755e-08 11 Parkinson's disease www.genome.jp/d...
KEGG 05010 View Gene Set 5.814e-09 168 1.037e-07 12 Alzheimer's disease www.genome.jp/d...
KEGG 03050 View Gene Set 2.783e-08 48 4.581e-07 13 Proteasome www.genome.jp/d...
KEGG 04114 View Gene Set 7.883e-08 114 1.205e-06 14 Oocyte meiosis www.genome.jp/d...
KEGG 00970 View Gene Set 9.561e-08 41 1.364e-06 15 Aminoacyl-tRNA biosynthesis www.genome.jp/d...
KEGG 03060 View Gene Set 2.231e-07 24 2.984e-06 16 Protein export www.genome.jp/d...
KEGG 03030 View Gene Set 3.726e-07 36 4.69e-06 17 DNA replication www.genome.jp/d...
KEGG 03420 View Gene Set 1.498e-06 44 1.781e-05 18 Nucleotide excision repair www.genome.jp/d...
KEGG 00020 View Gene Set 1.662e-06 31 1.872e-05 19 Citrate cycle (TCA cycle) www.genome.jp/d...
KEGG 05131 View Gene Set 1.779e-06 64 1.904e-05 20 Shigellosis www.genome.jp/d...
KEGG 05215 View Gene Set 2.258e-06 89 2.301e-05 21 Prostate cancer www.genome.jp/d...
KEGG 05220 View Gene Set 2.457e-06 73 2.39e-05 22 Chronic myeloid leukemia www.genome.jp/d...
KEGG 03410 View Gene Set 1.029e-05 34 9.177e-05 23 Base excision repair www.genome.jp/d...
KEGG 04150 View Gene Set 1.01e-05 52 9.177e-05 23 mTOR signaling pathway www.genome.jp/d...
KEGG 00510 View Gene Set 1.814e-05 48 0.0001553 25 N-Glycan biosynthesis www.genome.jp/d...
KEGG 00270 View Gene Set 2.633e-05 34 0.0002167 26 Cysteine and methionine metabolism www.genome.jp/d...
KEGG 05212 View Gene Set 2.764e-05 70 0.0002191 27 Pancreatic cancer www.genome.jp/d...
KEGG 05222 View Gene Set 6.741e-05 84 0.0005152 28 Small cell lung cancer www.genome.jp/d...
KEGG 00230 View Gene Set 9.791e-05 161 0.0006682 29 Purine metabolism www.genome.jp/d...
KEGG 04146 View Gene Set 9.992e-05 78 0.0006682 29 Peroxisome www.genome.jp/d...
KEGG 04210 View Gene Set 9.881e-05 88 0.0006682 29 Apoptosis www.genome.jp/d...
KEGG 05223 View Gene Set 9.437e-05 54 0.0006682 29 Non-small cell lung cancer www.genome.jp/d...
KEGG 04914 View Gene Set 0.0001131 87 0.0007332 33 Progesterone-mediated oocyte maturation www.genome.jp/d...
KEGG 05219 View Gene Set 0.0001514 42 0.000953 34 Bladder cancer www.genome.jp/d...
KEGG 03430 View Gene Set 0.0004161 23 0.002544 35 Mismatch repair www.genome.jp/d...
KEGG 00310 View Gene Set 0.0004374 46 0.0026 36 Lysine degradation www.genome.jp/d...
KEGG 04142 View Gene Set 0.0004517 121 0.002612 37 Lysosome www.genome.jp/d...
KEGG 05213 View Gene Set 0.0004858 52 0.002736 38 Endometrial cancer www.genome.jp/d...
KEGG 04962 View Gene Set 0.0006568 44 0.003604 39 Vasopressin-regulated water reabsorption www.genome.jp/d...
KEGG 05221 View Gene Set 0.0007613 60 0.004073 40 Acute myeloid leukemia www.genome.jp/d...
KEGG 05100 View Gene Set 0.001324 73 0.006912 41 Bacterial invasion of epithelial cells www.genome.jp/d...
KEGG 00290 View Gene Set 0.00167 11 0.008511 42 Valine leucine and isoleucine biosynthesis www.genome.jp/d...
KEGG 05214 View Gene Set 0.001772 65 0.008702 43 Glioma www.genome.jp/d...
KEGG 05216 View Gene Set 0.001789 29 0.008702 43 Thyroid cancer www.genome.jp/d...
KEGG 00670 View Gene Set 0.001855 17 0.008823 45 One carbon pool by folate www.genome.jp/d...
KEGG 00330 View Gene Set 0.001947 54 0.009056 46 Arginine and proline metabolism www.genome.jp/d...
KEGG 05211 View Gene Set 0.002648 70 0.01206 47 Renal cell carcinoma www.genome.jp/d...
KEGG 03020 View Gene Set 0.002712 29 0.01209 48 RNA polymerase www.genome.jp/d...
KEGG 00563 View Gene Set 0.003276 25 0.01431 49 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis www.genome.jp/d...
KEGG 00100 View Gene Set 0.003345 17 0.01432 50 Steroid biosynthesis www.genome.jp/d...
KEGG 00620 View Gene Set 0.003783 40 0.01587 51 Pyruvate metabolism www.genome.jp/d...
KEGG 00860 View Gene Set 0.004205 43 0.0173 52 Porphyrin and chlorophyll metabolism www.genome.jp/d...
KEGG 04910 View Gene Set 0.004545 137 0.01835 53 Insulin signaling pathway www.genome.jp/d...
KEGG 00280 View Gene Set 0.005516 44 0.02186 54 Valine leucine and isoleucine degradation www.genome.jp/d...
KEGG 00010 View Gene Set 0.006019 64 0.02342 55 Glycolysis / Gluconeogenesis www.genome.jp/d...
KEGG 05218 View Gene Set 0.006714 71 0.02566 56 Melanoma www.genome.jp/d...
KEGG 04722 View Gene Set 0.007652 126 0.02873 57 Neurotrophin signaling pathway www.genome.jp/d...
KEGG 03440 View Gene Set 0.008096 28 0.02987 58 Homologous recombination www.genome.jp/d...
KEGG 00750 View Gene Set 0.008914 6 0.03233 59 Vitamin B6 metabolism www.genome.jp/d...
KEGG 00450 View Gene Set 0.01025 26 0.03656 60 Selenoamino acid metabolism www.genome.jp/d...
KEGG 05110 View Gene Set 0.01129 56 0.0396 61 Vibrio cholerae infection www.genome.jp/d...
KEGG 00640 View Gene Set 0.01447 33 0.04994 62 Propanoate metabolism www.genome.jp/d...

Gene Set Collection: GO

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
GO GO:0044424 View Gene Set 3.815e-180 10976 5.097e-176 1 intracellular part amigo.geneontol...
GO GO:0005622 View Gene Set 6.531e-176 11329 4.363e-172 2 intracellular amigo.geneontol...
GO GO:0043227 View Gene Set 2.36e-171 8383 1.051e-167 3 membrane-bounded organelle amigo.geneontol...
GO GO:0043231 View Gene Set 8.14e-171 8376 2.719e-167 4 intracellular membrane-bounded organelle amigo.geneontol...
GO GO:0043229 View Gene Set 4.472e-160 9346 1.195e-156 5 intracellular organelle amigo.geneontol...
GO GO:0043226 View Gene Set 5.205e-159 9360 1.159e-155 6 organelle amigo.geneontol...
GO GO:0005737 View Gene Set 5.201e-131 7676 9.926e-128 7 cytoplasm amigo.geneontol...
GO GO:0044446 View Gene Set 7.073e-126 5019 1.181e-122 8 intracellular organelle part amigo.geneontol...
GO GO:0044422 View Gene Set 2.206e-122 5089 3.275e-119 9 organelle part amigo.geneontol...
GO GO:0044444 View Gene Set 4.017e-118 5184 5.367e-115 10 cytoplasmic part amigo.geneontol...
GO GO:0070013 View Gene Set 2.803e-104 1845 3.405e-101 11 intracellular organelle lumen amigo.geneontol...
GO GO:0031974 View Gene Set 1.181e-101 1917 1.314e-98 12 membrane-enclosed lumen amigo.geneontol...
GO GO:0043233 View Gene Set 2.75e-100 1881 2.826e-97 13 organelle lumen amigo.geneontol...
GO GO:0044237 View Gene Set 3.505e-96 7431 3.344e-93 14 cellular metabolic process amigo.geneontol...
GO GO:0044428 View Gene Set 6.967e-94 1938 6.205e-91 15 nuclear part amigo.geneontol...
GO GO:0005634 View Gene Set 3.773e-86 5198 3.151e-83 16 nucleus amigo.geneontol...
GO GO:0044260 View Gene Set 2.855e-82 5699 2.243e-79 17 cellular macromolecule metabolic process amigo.geneontol...
GO GO:0030529 View Gene Set 2.425e-81 504 1.8e-78 18 ribonucleoprotein complex amigo.geneontol...
GO GO:0031981 View Gene Set 4.527e-81 1518 3.183e-78 19 nuclear lumen amigo.geneontol...
GO GO:0008152 View Gene Set 1.811e-74 8439 1.21e-71 20 metabolic process amigo.geneontol...
GO GO:0005739 View Gene Set 1.675e-73 1274 1.066e-70 21 mitochondrion amigo.geneontol...
GO GO:0044464 View Gene Set 2.993e-73 15066 1.818e-70 22 cell part amigo.geneontol...
GO GO:0005623 View Gene Set 3.608e-73 15067 2.096e-70 23 cell amigo.geneontol...
GO GO:0032991 View Gene Set 4.917e-71 3237 2.737e-68 24 macromolecular complex amigo.geneontol...
GO GO:0044238 View Gene Set 3.79e-70 7629 2.026e-67 25 primary metabolic process amigo.geneontol...
GO GO:0003723 View Gene Set 6.895e-70 732 3.543e-67 26 RNA binding amigo.geneontol...
GO GO:0043170 View Gene Set 5.938e-62 6274 2.938e-59 27 macromolecule metabolic process amigo.geneontol...
GO GO:0006412 View Gene Set 1.573e-60 412 7.506e-58 28 translation amigo.geneontol...
GO GO:0044267 View Gene Set 3.55e-57 2465 1.635e-54 29 cellular protein metabolic process amigo.geneontol...
GO GO:0006396 View Gene Set 1.401e-54 578 6.237e-52 30 RNA processing amigo.geneontol...
GO GO:0005654 View Gene Set 7.906e-52 939 3.407e-49 31 nucleoplasm amigo.geneontol...
GO GO:0009987 View Gene Set 1.403e-51 11620 5.858e-49 32 cellular process amigo.geneontol...
GO GO:0005515 View Gene Set 3.009e-51 8146 1.218e-48 33 protein binding amigo.geneontol...
GO GO:0034641 View Gene Set 2.203e-49 4584 8.657e-47 34 cellular nitrogen compound metabolic process amigo.geneontol...
GO GO:0010467 View Gene Set 1.771e-47 3806 6.761e-45 35 gene expression amigo.geneontol...
GO GO:0006807 View Gene Set 4.955e-47 4698 1.839e-44 36 nitrogen compound metabolic process amigo.geneontol...
GO GO:0005840 View Gene Set 8.643e-47 198 3.121e-44 37 ribosome amigo.geneontol...
GO GO:0006139 View Gene Set 6.457e-46 4294 2.27e-43 38 nucleobase nucleoside nucleotide and nucleic acid metabolic process amigo.geneontol...
GO GO:0005488 View Gene Set 9.731e-46 12334 3.333e-43 39 binding amigo.geneontol...
GO GO:0090304 View Gene Set 1.391e-45 3724 4.645e-43 40 nucleic acid metabolic process amigo.geneontol...
GO GO:0005730 View Gene Set 1.349e-44 734 4.397e-42 41 nucleolus amigo.geneontol...
GO GO:0003824 View Gene Set 4.752e-43 5198 1.512e-40 42 catalytic activity amigo.geneontol...
GO GO:0043228 View Gene Set 6.161e-43 2690 1.871e-40 43 non-membrane-bounded organelle amigo.geneontol...
GO GO:0043232 View Gene Set 6.161e-43 2690 1.871e-40 43 intracellular non-membrane-bounded organelle amigo.geneontol...
GO GO:0044429 View Gene Set 8.639e-42 619 2.565e-39 45 mitochondrial part amigo.geneontol...
GO GO:0005829 View Gene Set 1.732e-40 1323 5.03e-38 46 cytosol amigo.geneontol...
GO GO:0003676 View Gene Set 1.133e-39 2979 3.221e-37 47 nucleic acid binding amigo.geneontol...
GO GO:0044249 View Gene Set 1.447e-39 4326 4.029e-37 48 cellular biosynthetic process amigo.geneontol...
GO GO:0005575 View Gene Set 1.874e-39 16391 5.11e-37 49 cellular_component amigo.geneontol...
GO GO:0009058 View Gene Set 2.988e-38 4436 7.984e-36 50 biosynthetic process amigo.geneontol...
GO GO:0003735 View Gene Set 1.927e-37 158 5.048e-35 51 structural constituent of ribosome amigo.geneontol...
GO GO:0031967 View Gene Set 3.894e-37 672 1e-34 52 organelle envelope amigo.geneontol...
GO GO:0031090 View Gene Set 7.505e-37 1905 1.892e-34 53 organelle membrane amigo.geneontol...
GO GO:0019538 View Gene Set 2.576e-36 2935 6.373e-34 54 protein metabolic process amigo.geneontol...
GO GO:0003674 View Gene Set 2.693e-36 15462 6.541e-34 55 molecular_function amigo.geneontol...
GO GO:0022613 View Gene Set 5.922e-36 194 1.413e-33 56 ribonucleoprotein complex biogenesis amigo.geneontol...
GO GO:0031975 View Gene Set 7.148e-36 685 1.675e-33 57 envelope amigo.geneontol...
GO GO:0034645 View Gene Set 5.79e-35 3529 1.334e-32 58 cellular macromolecule biosynthetic process amigo.geneontol...
GO GO:0009059 View Gene Set 6.176e-32 3597 1.398e-29 59 macromolecule biosynthetic process amigo.geneontol...
GO GO:0008150 View Gene Set 1.765e-31 14318 3.929e-29 60 biological_process amigo.geneontol...
GO GO:0016071 View Gene Set 6.398e-31 381 1.401e-28 61 mRNA metabolic process amigo.geneontol...
GO GO:0008380 View Gene Set 1.372e-30 300 2.957e-28 62 RNA splicing amigo.geneontol...
GO GO:0033279 View Gene Set 1.668e-30 121 3.538e-28 63 ribosomal subunit amigo.geneontol...
GO GO:0043234 View Gene Set 1.831e-30 2680 3.822e-28 64 protein complex amigo.geneontol...
GO GO:0046907 View Gene Set 7.401e-30 753 1.521e-27 65 intracellular transport amigo.geneontol...
GO GO:0005740 View Gene Set 7.698e-29 444 1.558e-26 66 mitochondrial envelope amigo.geneontol...
GO GO:0031966 View Gene Set 5.175e-28 420 1.032e-25 67 mitochondrial membrane amigo.geneontol...
GO GO:0034660 View Gene Set 1.578e-27 236 3.101e-25 68 ncRNA metabolic process amigo.geneontol...
GO GO:0006414 View Gene Set 1.627e-27 104 3.15e-25 69 translational elongation amigo.geneontol...
GO GO:0007049 View Gene Set 3.065e-27 1006 5.85e-25 70 cell cycle amigo.geneontol...
GO GO:0042254 View Gene Set 5.539e-27 130 1.028e-24 71 ribosome biogenesis amigo.geneontol...
GO GO:0044451 View Gene Set 5.533e-27 600 1.028e-24 71 nucleoplasm part amigo.geneontol...
GO GO:0044265 View Gene Set 5.826e-27 479 1.066e-24 73 cellular macromolecule catabolic process amigo.geneontol...
GO GO:0032446 View Gene Set 1.55e-26 310 2.798e-24 74 protein modification by small protein conjugation amigo.geneontol...
GO GO:0006259 View Gene Set 1.673e-26 592 2.98e-24 75 DNA metabolic process amigo.geneontol...
GO GO:0070647 View Gene Set 2.19e-26 356 3.851e-24 76 protein modification by small protein conjugation or removal amigo.geneontol...
GO GO:0034470 View Gene Set 1.552e-25 193 2.693e-23 77 ncRNA processing amigo.geneontol...
GO GO:0006397 View Gene Set 2.26e-25 317 3.87e-23 78 mRNA processing amigo.geneontol...
GO GO:0016070 View Gene Set 2.376e-25 2596 4.018e-23 79 RNA metabolic process amigo.geneontol...
GO GO:0000166 View Gene Set 2.854e-25 2257 4.766e-23 80 nucleotide binding amigo.geneontol...
GO GO:0009057 View Gene Set 5.26e-25 570 8.676e-23 81 macromolecule catabolic process amigo.geneontol...
GO GO:0045184 View Gene Set 1.05e-24 904 1.71e-22 82 establishment of protein localization amigo.geneontol...
GO GO:0015031 View Gene Set 1.205e-24 888 1.939e-22 83 protein transport amigo.geneontol...
GO GO:0016567 View Gene Set 6.839e-24 286 1.088e-21 84 protein ubiquitination amigo.geneontol...
GO GO:0008104 View Gene Set 1.181e-23 1048 1.856e-21 85 protein localization amigo.geneontol...
GO GO:0006996 View Gene Set 6.753e-23 1501 1.049e-20 86 organelle organization amigo.geneontol...
GO GO:0006974 View Gene Set 1.23e-22 412 1.889e-20 87 response to DNA damage stimulus amigo.geneontol...
GO GO:0005694 View Gene Set 1.986e-21 507 3.015e-19 88 chromosome amigo.geneontol...
GO GO:0019866 View Gene Set 3.195e-21 334 4.797e-19 89 organelle inner membrane amigo.geneontol...
GO GO:0033036 View Gene Set 4.472e-21 1256 6.639e-19 90 macromolecule localization amigo.geneontol...
GO GO:0044445 View Gene Set 6.847e-21 148 1.005e-18 91 cytosolic part amigo.geneontol...
GO GO:0006457 View Gene Set 9.651e-21 172 1.401e-18 92 protein folding amigo.geneontol...
GO GO:0044085 View Gene Set 1.727e-20 1167 2.481e-18 93 cellular component biogenesis amigo.geneontol...
GO GO:0005759 View Gene Set 3.173e-20 223 4.462e-18 94 mitochondrial matrix amigo.geneontol...
GO GO:0031980 View Gene Set 3.173e-20 223 4.462e-18 94 mitochondrial lumen amigo.geneontol...
GO GO:0000278 View Gene Set 3.641e-20 489 5.067e-18 96 mitotic cell cycle amigo.geneontol...
GO GO:0022402 View Gene Set 5.419e-20 676 7.463e-18 97 cell cycle process amigo.geneontol...
GO GO:0019941 View Gene Set 5.94e-20 302 8.016e-18 98 modification-dependent protein catabolic process amigo.geneontol...
GO GO:0043632 View Gene Set 5.94e-20 302 8.016e-18 98 modification-dependent macromolecule catabolic process amigo.geneontol...
GO GO:0022626 View Gene Set 6.77e-20 75 9.045e-18 100 cytosolic ribosome amigo.geneontol...
GO GO:0005743 View Gene Set 8.323e-20 305 1.101e-17 101 mitochondrial inner membrane amigo.geneontol...
GO GO:0006364 View Gene Set 1.234e-19 97 1.617e-17 102 rRNA processing amigo.geneontol...
GO GO:0006511 View Gene Set 1.892e-19 296 2.451e-17 103 ubiquitin-dependent protein catabolic process amigo.geneontol...
GO GO:0016072 View Gene Set 1.908e-19 101 2.451e-17 103 rRNA metabolic process amigo.geneontol...
GO GO:0016874 View Gene Set 4.044e-19 436 5.146e-17 105 ligase activity amigo.geneontol...
GO GO:0005783 View Gene Set 5.998e-19 1024 7.56e-17 106 endoplasmic reticulum amigo.geneontol...
GO GO:0030163 View Gene Set 6.085e-19 398 7.597e-17 107 protein catabolic process amigo.geneontol...
GO GO:0051603 View Gene Set 6.191e-19 346 7.659e-17 108 proteolysis involved in cellular protein catabolic process amigo.geneontol...
GO GO:0044257 View Gene Set 7.18e-19 349 8.8e-17 109 cellular protein catabolic process amigo.geneontol...
GO GO:0044432 View Gene Set 9.848e-19 689 1.196e-16 110 endoplasmic reticulum part amigo.geneontol...
GO GO:0051276 View Gene Set 1.801e-18 548 2.168e-16 111 chromosome organization amigo.geneontol...
GO GO:0010498 View Gene Set 2.544e-18 166 3.034e-16 112 proteasomal protein catabolic process amigo.geneontol...
GO GO:0016604 View Gene Set 2.654e-18 198 3.138e-16 113 nuclear body amigo.geneontol...
GO GO:0044248 View Gene Set 3.08e-18 1005 3.609e-16 114 cellular catabolic process amigo.geneontol...
GO GO:0006281 View Gene Set 4.911e-18 309 5.705e-16 115 DNA repair amigo.geneontol...
GO GO:0043161 View Gene Set 1.113e-17 162 1.282e-15 116 proteasomal ubiquitin-dependent protein catabolic process amigo.geneontol...
GO GO:0000375 View Gene Set 1.26e-17 106 1.439e-15 117 RNA splicing via transesterification reactions amigo.geneontol...
GO GO:0071212 View Gene Set 1.518e-17 723 1.718e-15 118 subsynaptic reticulum amigo.geneontol...
GO GO:0043933 View Gene Set 1.577e-17 836 1.77e-15 119 macromolecular complex subunit organization amigo.geneontol...
GO GO:0033554 View Gene Set 3.128e-17 698 3.482e-15 120 cellular response to stress amigo.geneontol...
GO GO:0006886 View Gene Set 3.172e-17 439 3.503e-15 121 intracellular protein transport amigo.geneontol...
GO GO:0015934 View Gene Set 3.214e-17 64 3.52e-15 122 large ribosomal subunit amigo.geneontol...
GO GO:0065003 View Gene Set 3.408e-17 763 3.702e-15 123 macromolecular complex assembly amigo.geneontol...
GO GO:0070727 View Gene Set 3.836e-17 503 4.133e-15 124 cellular macromolecule localization amigo.geneontol...
GO GO:0044427 View Gene Set 6.945e-17 420 7.423e-15 125 chromosomal part amigo.geneontol...
GO GO:0005789 View Gene Set 8.864e-17 622 9.399e-15 126 endoplasmic reticulum membrane amigo.geneontol...
GO GO:0034613 View Gene Set 9.082e-17 501 9.554e-15 127 cellular protein localization amigo.geneontol...
GO GO:0042175 View Gene Set 1.475e-16 637 1.539e-14 128 nuclear membrane-endoplasmic reticulum network amigo.geneontol...
GO GO:0005681 View Gene Set 2.774e-16 135 2.873e-14 129 spliceosomal complex amigo.geneontol...
GO GO:0000377 View Gene Set 2.84e-16 97 2.897e-14 130 RNA splicing via transesterification reactions with bulged adenosine as nucleophile amigo.geneontol...
GO GO:0000398 View Gene Set 2.84e-16 97 2.897e-14 130 nuclear mRNA splicing via spliceosome amigo.geneontol...
GO GO:0006260 View Gene Set 4.079e-16 239 4.128e-14 132 DNA replication amigo.geneontol...
GO GO:0015935 View Gene Set 4.672e-16 59 4.693e-14 133 small ribosomal subunit amigo.geneontol...
GO GO:0016568 View Gene Set 1.939e-15 324 1.933e-13 134 chromatin modification amigo.geneontol...
GO GO:0022403 View Gene Set 2.298e-15 522 2.274e-13 135 cell cycle phase amigo.geneontol...
GO GO:0044419 View Gene Set 3.563e-15 343 3.5e-13 136 interspecies interaction between organisms amigo.geneontol...
GO GO:0006091 View Gene Set 4.87e-15 339 4.749e-13 137 generation of precursor metabolites and energy amigo.geneontol...
GO GO:0034621 View Gene Set 5.827e-15 458 5.641e-13 138 cellular macromolecular complex subunit organization amigo.geneontol...
GO GO:0044455 View Gene Set 9.617e-15 133 9.243e-13 139 mitochondrial membrane part amigo.geneontol...
GO GO:0008135 View Gene Set 1.115e-14 86 1.064e-12 140 translation factor activity nucleic acid binding amigo.geneontol...
GO GO:0051301 View Gene Set 2.02e-14 358 1.914e-12 141 cell division amigo.geneontol...
GO GO:0010608 View Gene Set 2.214e-14 247 2.083e-12 142 posttranscriptional regulation of gene expression amigo.geneontol...
GO GO:0048285 View Gene Set 2.823e-14 286 2.638e-12 143 organelle fission amigo.geneontol...
GO GO:0009056 View Gene Set 3.512e-14 1255 3.259e-12 144 catabolic process amigo.geneontol...
GO GO:0022618 View Gene Set 3.814e-14 76 3.514e-12 145 ribonucleoprotein complex assembly amigo.geneontol...
GO GO:0000087 View Gene Set 7.214e-14 286 6.557e-12 146 M phase of mitotic cell cycle amigo.geneontol...
GO GO:0000279 View Gene Set 7.211e-14 406 6.557e-12 146 M phase amigo.geneontol...
GO GO:0000280 View Gene Set 9.273e-14 276 8.314e-12 148 nuclear division amigo.geneontol...
GO GO:0007067 View Gene Set 9.273e-14 276 8.314e-12 148 mitosis amigo.geneontol...
GO GO:0006399 View Gene Set 9.787e-14 118 8.717e-12 150 tRNA metabolic process amigo.geneontol...
GO GO:0031396 View Gene Set 1.06e-13 121 9.374e-12 151 regulation of protein ubiquitination amigo.geneontol...
GO GO:0012505 View Gene Set 1.601e-13 1454 1.407e-11 152 endomembrane system amigo.geneontol...
GO GO:0051082 View Gene Set 2.38e-13 113 2.078e-11 153 unfolded protein binding amigo.geneontol...
GO GO:0006325 View Gene Set 2.88e-13 425 2.499e-11 154 chromatin organization amigo.geneontol...
GO GO:0051438 View Gene Set 3.615e-13 82 3.116e-11 155 regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0043412 View Gene Set 5.278e-13 1848 4.52e-11 156 macromolecule modification amigo.geneontol...
GO GO:0031398 View Gene Set 5.737e-13 95 4.882e-11 157 positive regulation of protein ubiquitination amigo.geneontol...
GO GO:0016879 View Gene Set 5.834e-13 273 4.933e-11 158 ligase activity forming carbon-nitrogen bonds amigo.geneontol...
GO GO:0016740 View Gene Set 6.436e-13 1691 5.408e-11 159 transferase activity amigo.geneontol...
GO GO:0034622 View Gene Set 7.965e-13 393 6.651e-11 160 cellular macromolecular complex assembly amigo.geneontol...
GO GO:0051649 View Gene Set 8.778e-13 1116 7.284e-11 161 establishment of localization in cell amigo.geneontol...
GO GO:0017076 View Gene Set 9.085e-13 1934 7.492e-11 162 purine nucleotide binding amigo.geneontol...
GO GO:0060255 View Gene Set 9.834e-13 3411 8.061e-11 163 regulation of macromolecule metabolic process amigo.geneontol...
GO GO:0051641 View Gene Set 1.166e-12 1206 9.501e-11 164 cellular localization amigo.geneontol...
GO GO:0016043 View Gene Set 1.288e-12 2937 1.043e-10 165 cellular component organization amigo.geneontol...
GO GO:0006417 View Gene Set 1.48e-12 151 1.191e-10 166 regulation of translation amigo.geneontol...
GO GO:0005819 View Gene Set 1.702e-12 167 1.362e-10 167 spindle amigo.geneontol...
GO GO:0051340 View Gene Set 2.214e-12 85 1.761e-10 168 regulation of ligase activity amigo.geneontol...
GO GO:0019787 View Gene Set 2.348e-12 210 1.856e-10 169 small conjugating protein ligase activity amigo.geneontol...
GO GO:0006413 View Gene Set 3.238e-12 62 2.545e-10 170 translational initiation amigo.geneontol...
GO GO:0032553 View Gene Set 4.843e-12 1851 3.762e-10 171 ribonucleotide binding amigo.geneontol...
GO GO:0032555 View Gene Set 4.843e-12 1851 3.762e-10 171 purine ribonucleotide binding amigo.geneontol...
GO GO:0051246 View Gene Set 5.109e-12 652 3.924e-10 173 regulation of protein metabolic process amigo.geneontol...
GO GO:0016853 View Gene Set 5.11e-12 132 3.924e-10 173 isomerase activity amigo.geneontol...
GO GO:0051443 View Gene Set 5.545e-12 71 4.233e-10 175 positive regulation of ubiquitin-protein ligase activity amigo.geneontol...
GO GO:0000775 View Gene Set 6.596e-12 146 5.007e-10 176 chromosome centromeric region amigo.geneontol...
GO GO:0032268 View Gene Set 7.097e-12 576 5.357e-10 177 regulation of cellular protein metabolic process amigo.geneontol...
GO GO:0006839 View Gene Set 8.864e-12 75 6.653e-10 178 mitochondrial transport amigo.geneontol...
GO GO:0008565 View Gene Set 1.001e-11 85 7.468e-10 179 protein transporter activity amigo.geneontol...
GO GO:0006464 View Gene Set 1.179e-11 1768 8.75e-10 180 protein modification process amigo.geneontol...
GO GO:0000502 View Gene Set 1.372e-11 63 1.013e-09 181 proteasome complex amigo.geneontol...
GO GO:0051439 View Gene Set 1.465e-11 68 1.075e-09 182 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle amigo.geneontol...
GO GO:0003743 View Gene Set 1.932e-11 52 1.41e-09 183 translation initiation factor activity amigo.geneontol...
GO GO:0022900 View Gene Set 2.353e-11 115 1.709e-09 184 electron transport chain amigo.geneontol...
GO GO:0001882 View Gene Set 2.554e-11 1630 1.844e-09 185 nucleoside binding amigo.geneontol...
GO GO:0000313 View Gene Set 2.863e-11 49 2.045e-09 186 organellar ribosome amigo.geneontol...
GO GO:0005761 View Gene Set 2.863e-11 49 2.045e-09 186 mitochondrial ribosome amigo.geneontol...
GO GO:0008134 View Gene Set 3.495e-11 525 2.484e-09 188 transcription factor binding amigo.geneontol...
GO GO:0051351 View Gene Set 3.567e-11 74 2.522e-09 189 positive regulation of ligase activity amigo.geneontol...
GO GO:0010605 View Gene Set 3.648e-11 827 2.565e-09 190 negative regulation of macromolecule metabolic process amigo.geneontol...
GO GO:0022625 View Gene Set 4.041e-11 36 2.827e-09 191 cytosolic large ribosomal subunit amigo.geneontol...
GO GO:0001883 View Gene Set 4.35e-11 1620 3.027e-09 192 purine nucleoside binding amigo.geneontol...
GO GO:0006605 View Gene Set 4.704e-11 273 3.256e-09 193 protein targeting amigo.geneontol...
GO GO:0016607 View Gene Set 5.276e-11 116 3.633e-09 194 nuclear speck amigo.geneontol...
GO GO:0048037 View Gene Set 5.333e-11 249 3.654e-09 195 cofactor binding amigo.geneontol...
GO GO:0051437 View Gene Set 6.114e-11 64 4.167e-09 196 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle amigo.geneontol...
GO GO:0005635 View Gene Set 7.196e-11 234 4.88e-09 197 nuclear envelope amigo.geneontol...
GO GO:0030530 View Gene Set 7.838e-11 17 5.289e-09 198 heterogeneous nuclear ribonucleoprotein complex amigo.geneontol...
GO GO:0006626 View Gene Set 8.223e-11 32 5.493e-09 199 protein targeting to mitochondrion amigo.geneontol...
GO GO:0070585 View Gene Set 8.223e-11 32 5.493e-09 199 protein localization in mitochondrion amigo.geneontol...

Gene Set Collection: Broad.c2.CGP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP View Gene Set 2.723e-147 1353 6.514e-144 1 Genes up-regulated in CD34+ [Gene ID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients compared to those from normal donors. www.broad.mit.e...
Broad PUJANA_BRCA1_PCC_NETWORK View Gene Set 2.94e-130 1582 3.517e-127 2 Genes constituting the BRCA1-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA1 [Gene ID=672] across a compendium of normal tissues. www.broad.mit.e...
Broad CAIRO_HEPATOBLASTOMA_CLASSES_UP View Gene Set 7.391e-117 577 5.893e-114 3 Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). www.broad.mit.e...
Broad PUJANA_CHEK2_PCC_NETWORK View Gene Set 7.391e-111 744 4.42e-108 4 Genes constituting the CHEK2-PCC network of transcripts whose expression positively correlates (Pearson correlation coefficient PCC >= 0.4) with that of CHEK2 [Gene ID=11200]. www.broad.mit.e...
Broad DODD_NASOPHARYNGEAL_CARCINOMA_DN View Gene Set 3.557e-99 1253 1.702e-96 5 Genes down-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. www.broad.mit.e...
Broad KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP View Gene Set 5.043e-82 1180 2.01e-79 6 Genes up-regulated in TC71 and EWS502 cells (Ewing's sarcoma) upon knockdown of the EWSR1-FLII fusion [Gene ID=2130 2314]. www.broad.mit.e...
Broad HSIAO_HOUSEKEEPING_GENES View Gene Set 3.434e-75 384 1.173e-72 7 Housekeeping genes identified as expressed across 19 normal tissues. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_24HR_UP View Gene Set 5.636e-73 537 1.685e-70 8 Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. www.broad.mit.e...
Broad WEI_MYCN_TARGETS_WITH_E_BOX View Gene Set 1.082e-64 757 2.876e-62 9 Genes whose promoters contain E-box motifs and whose expression changed in MYCN-3 cells (neuroblastoma) upon induction of MYCN [Gene ID=4613]. www.broad.mit.e...
Broad ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP View Gene Set 4.194e-64 806 1.003e-61 10 Genes up-regulated in liver tumor compared to the normal adjacent tissue. www.broad.mit.e...
Broad WONG_EMBRYONIC_STEM_CELL_CORE View Gene Set 1.995e-63 331 4.339e-61 11 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. www.broad.mit.e...
Broad DANG_BOUND_BY_MYC View Gene Set 2.891e-63 1045 5.763e-61 12 Genes whose promoters are bound by MYC [Gene ID=4609] according to MYC Target Gene Database. www.broad.mit.e...
Broad GRADE_COLON_CANCER_UP View Gene Set 7.436e-62 711 1.368e-59 13 Up-regulated genes in colon carcinoma tumors compared to the matched normal mucosa samples. www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_DN View Gene Set 1.25e-59 1209 2.136e-57 14 Genes down-regulated in brain from patients with Alzheimer's disease. www.broad.mit.e...
Broad ACEVEDO_LIVER_CANCER_UP View Gene Set 2.221e-58 915 3.542e-56 15 Genes up-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples. www.broad.mit.e...
Broad CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN View Gene Set 3.599e-58 639 5.38e-56 16 Genes down-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [Gene ID=5371 5914] compared to normal promyeloblasts. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN View Gene Set 5.645e-57 920 7.943e-55 17 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h. www.broad.mit.e...
Broad BENPORATH_MYC_MAX_TARGETS View Gene Set 6.931e-57 768 9.21e-55 18 Set 'Myc targets2': targets of c-Myc [Gene ID=4609] and Max [Gene ID=4149] identified by ChIP on chip in a Burkitt???s lymphoma cell line; overlap set. www.broad.mit.e...
Broad RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN View Gene Set 1.379e-56 351 1.736e-54 19 Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. www.broad.mit.e...
Broad NUYTTEN_EZH2_TARGETS_DN View Gene Set 2.063e-56 859 2.467e-54 20 Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [Gene ID=2146] by RNAi. www.broad.mit.e...
Broad SHEN_SMARCA2_TARGETS_UP View Gene Set 5.219e-56 406 5.945e-54 21 Genes whose expression positively correlated with that of SMARCA2 [Gene ID=6595] in prostate cancer samples. www.broad.mit.e...
Broad BORCZUK_MALIGNANT_MESOTHELIOMA_UP View Gene Set 6.111e-54 290 6.644e-52 22 Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma. www.broad.mit.e...
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP View Gene Set 1.365e-51 469 1.42e-49 23 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP View Gene Set 2.792e-50 589 2.782e-48 24 Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. www.broad.mit.e...
Broad SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN View Gene Set 4.66e-49 571 4.459e-47 25 Genes down-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. www.broad.mit.e...
Broad SCHLOSSER_SERUM_RESPONSE_DN View Gene Set 1.235e-47 666 1.136e-45 26 Cluster 4: genes down-regulated in B493-6 cells (B lymphocytes) upon serum stimulation but not affected by MYC [Gene ID=4609]. www.broad.mit.e...
Broad ENK_UV_RESPONSE_KERATINOCYTE_DN View Gene Set 4.128e-47 475 3.657e-45 27 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN View Gene Set 8.664e-47 832 7.402e-45 28 Genes down-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h. www.broad.mit.e...
Broad MANALO_HYPOXIA_DN View Gene Set 2.226e-43 276 1.836e-41 29 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [Gene ID=3091]. www.broad.mit.e...
Broad MITSIADES_RESPONSE_TO_APLIDIN_DN View Gene Set 4.48e-43 241 3.572e-41 30 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164] a marine-derived compound with potential anti-cancer properties. www.broad.mit.e...
Broad PUJANA_ATM_PCC_NETWORK View Gene Set 2.808e-42 1375 2.166e-40 31 Genes constituting the ATM-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of ATM [Gene ID=472] across a compendium of normal tissues. www.broad.mit.e...
Broad BERENJENO_TRANSFORMED_BY_RHOA_UP View Gene Set 3.143e-42 485 2.349e-40 32 Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [Gene ID=387] off plasmid vector. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM View Gene Set 1.531e-41 154 1.11e-39 33 Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] and down-regulated by the combination of MYC and serum. www.broad.mit.e...
Broad MOOTHA_MITOCHONDRIA View Gene Set 2.648e-41 433 1.863e-39 34 Mitochondrial genes www.broad.mit.e...
Broad BENPORATH_CYCLING_GENES View Gene Set 1.001e-40 630 6.839e-39 35 Genes showing cell-cycle stage-specific expression [PMID=12058064]. www.broad.mit.e...
Broad LOPEZ_MBD_TARGETS View Gene Set 1.477e-40 855 9.814e-39 36 Genes up-regulated in HeLa cells (cervical cancer) after simultaneus knockdown of all three MBD (methyl-CpG binding domain) proteins MeCP2 MBD1 and MBD2 [Gene ID=4204 4152 8932] by RNAi. www.broad.mit.e...
Broad SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 View Gene Set 1.604e-40 435 1.037e-38 37 Cluster 6 of method A: up-regulation of these genes in patients with non???small cell lung cancer (NSCLC) predicts poor survival outcome. www.broad.mit.e...
Broad MOOTHA_HUMAN_MITODB_6_2002 View Gene Set 3.244e-39 420 2.042e-37 38 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. www.broad.mit.e...
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP View Gene Set 3.679e-39 532 2.256e-37 39 Genes diffierentially expressed in kidney biopsies from patients with well functioning kidneys more than 1-year post transplant compared to the biopsies from normal living kidney donors. www.broad.mit.e...
Broad GARY_CD5_TARGETS_DN View Gene Set 4.117e-39 415 2.462e-37 40 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [Gene ID=921] off a plasmid vector. www.broad.mit.e...
Broad MUELLER_PLURINET View Gene Set 6.31e-39 294 3.682e-37 41 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells embryonical carcinomas and induced pluripotent cells). www.broad.mit.e...
Broad ZHANG_BREAST_CANCER_PROGENITORS_UP View Gene Set 9.167e-39 370 5.221e-37 42 Genes changed in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. www.broad.mit.e...
Broad BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP View Gene Set 1.06e-38 184 5.896e-37 43 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3 defined by unsupervised clustering. www.broad.mit.e...
Broad PUJANA_BRCA2_PCC_NETWORK View Gene Set 2.475e-38 410 1.345e-36 44 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient PCC >= 0.4) with that of BRCA2 [Gene ID=675] across a compendium of normal tissues. www.broad.mit.e...
Broad TARTE_PLASMA_CELL_VS_PLASMABLAST_DN View Gene Set 3.954e-37 303 2.102e-35 45 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. www.broad.mit.e...
Broad MILI_PSEUDOPODIA_HAPTOTAXIS_UP View Gene Set 3.001e-36 452 1.561e-34 46 Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin FN1 [Gene ID=2335]. www.broad.mit.e...
Broad BIDUS_METASTASIS_UP View Gene Set 1.497e-35 203 7.621e-34 47 Genes up-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases. www.broad.mit.e...
Broad STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN View Gene Set 6.426e-35 437 3.202e-33 48 Genes down-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region. www.broad.mit.e...
Broad BENPORATH_NANOG_TARGETS View Gene Set 4.259e-34 946 2.079e-32 49 Set 'Nanog targets': genes upregulated and identified by ChIP on chip as Nanog [Gene ID=79923] transcription factor targets in human embryonic stem cells. www.broad.mit.e...
Broad LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN View Gene Set 6.73e-34 742 3.22e-32 50 Genes with copy number losses in primary neuroblastoma tumors. www.broad.mit.e...
Broad WONG_MITOCHONDRIA_GENE_MODULE View Gene Set 1.927e-32 208 9.036e-31 51 Genes that comprise the mitochondria gene module www.broad.mit.e...
Broad FOURNIER_ACINAR_DEVELOPMENT_LATE_2 View Gene Set 2.565e-32 265 1.18e-30 52 Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. www.broad.mit.e...
Broad MOHANKUMAR_TLX1_TARGETS_UP View Gene Set 8.044e-31 388 3.63e-29 53 Up-regulated in MCF7 cells (breast cancer) by TLX1 (HOX11) [Gene ID=3195]. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP View Gene Set 9.461e-31 681 4.191e-29 54 Genes up-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. www.broad.mit.e...
Broad LIU_SOX4_TARGETS_DN View Gene Set 2.955e-30 297 1.285e-28 55 Genes down-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [Gene ID=6659] and up-regulated by its RNAi knockdown. www.broad.mit.e...
Broad SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP View Gene Set 5.852e-30 143 2.5e-28 56 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. www.broad.mit.e...
Broad FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN View Gene Set 2.132e-29 532 8.947e-28 57 Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. www.broad.mit.e...
Broad ONKEN_UVEAL_MELANOMA_UP View Gene Set 2.794e-29 739 1.152e-27 58 Genes up-regulated in uveal melanoma: class 2 vs class 1 tumors. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 View Gene Set 8.938e-29 165 3.624e-27 59 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. www.broad.mit.e...
Broad DANG_MYC_TARGETS_UP View Gene Set 1.604e-28 127 6.396e-27 60 Genes up-regulated by MYC [Gene ID=4609] and whose promoters are bound by MYC according to MYC Target Gene Database. www.broad.mit.e...
Broad TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C View Gene Set 2.047e-28 436 8.025e-27 61 Genes down-regulated in HCT116 cells (colon cancer) upon expression of MIR34B or MIR34C [Gene ID=407041 407042] microRNAs. www.broad.mit.e...
Broad BLUM_RESPONSE_TO_SALIRASIB_DN View Gene Set 4.357e-28 332 1.681e-26 62 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_24HR_DN View Gene Set 4.438e-28 208 1.685e-26 63 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. www.broad.mit.e...
Broad HORIUCHI_WTAP_TARGETS_DN View Gene Set 4.86e-28 289 1.816e-26 64 Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [Gene ID=9589] by RNAi. www.broad.mit.e...
Broad MILI_PSEUDOPODIA_HAPTOTAXIS_DN View Gene Set 1.522e-27 607 5.603e-26 65 Transcripts depleted from pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin FN1 [Gene ID=2335]. www.broad.mit.e...
Broad MOOTHA_PGC View Gene Set 1.661e-27 329 6.021e-26 66 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [Gene ID=10891] off an adenoviral vector. www.broad.mit.e...
Broad NUYTTEN_NIPP1_TARGETS_DN View Gene Set 2.647e-27 758 9.451e-26 67 Genes down-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [Gene ID=5511] by RNAi. www.broad.mit.e...
Broad BENPORATH_SOX2_TARGETS View Gene Set 2.867e-27 704 1.009e-25 68 Set 'Sox2 targets': genes upregulated and identified by ChIP on chip as SOX2 [Gene ID=6657] transcription factor targets in human embryonic stem cells. www.broad.mit.e...
Broad BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN View Gene Set 3.189e-27 599 1.105e-25 69 Genes down-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. www.broad.mit.e...
Broad GRADE_COLON_AND_RECTAL_CANCER_UP View Gene Set 1.231e-26 213 4.206e-25 70 Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. www.broad.mit.e...
Broad CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN View Gene Set 1.327e-26 155 4.471e-25 71 Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. www.broad.mit.e...
Broad KOBAYASHI_EGFR_SIGNALING_24HR_DN View Gene Set 2.498e-26 243 8.3e-25 72 Genes down-regulated in H1975 cells (non-small cell lung cancer NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_CLUSTER_3_UP View Gene Set 5.033e-26 314 1.649e-24 73 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_DN View Gene Set 7.539e-26 825 2.437e-24 74 Genes down-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. www.broad.mit.e...
Broad WEST_ADRENOCORTICAL_TUMOR_UP View Gene Set 1.497e-25 283 4.773e-24 75 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. www.broad.mit.e...
Broad ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER View Gene Set 2.006e-25 138 6.313e-24 76 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. www.broad.mit.e...
Broad BENPORATH_PROLIFERATION View Gene Set 7.815e-25 140 2.428e-23 77 Set 'Proliferation Cluster': genes defined in human breast tumor expression data. www.broad.mit.e...
Broad PUJANA_XPRSS_INT_NETWORK View Gene Set 8.458e-25 164 2.594e-23 78 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200] in a compendium of normal tissues. www.broad.mit.e...
Broad RAMALHO_STEMNESS_UP View Gene Set 2.001e-24 192 6.06e-23 79 Genes enriched in embryonic neural and hematopoietic stem cells. www.broad.mit.e...
Broad DAIRKEE_TERT_TARGETS_UP View Gene Set 2.943e-24 317 8.8e-23 80 Genes up-regulated in non-spontaneously immortalizing (NSI) primary breast cancer tumor cultures upon expression of TERT [Gene ID=7015] off a retroviral vector. www.broad.mit.e...
Broad VECCHI_GASTRIC_CANCER_EARLY_UP View Gene Set 1.678e-23 408 4.956e-22 81 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. www.broad.mit.e...
Broad GARY_CD5_TARGETS_UP View Gene Set 2.246e-23 463 6.551e-22 82 Genes up-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [Gene ID=921] off a plasmid vector. www.broad.mit.e...
Broad WINNEPENNINCKX_MELANOMA_METASTASIS_UP View Gene Set 5.711e-23 152 1.646e-21 83 Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years. www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_UP View Gene Set 6.078e-23 1641 1.731e-21 84 Genes up-regulated in brain from patients with Alzheimer's disease. www.broad.mit.e...
Broad BLUM_RESPONSE_TO_SALIRASIB_UP View Gene Set 8.135e-23 240 2.289e-21 85 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [Gene ID=3265]. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 View Gene Set 1.86e-22 158 5.173e-21 86 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13. www.broad.mit.e...
Broad PAL_PRMT5_TARGETS_UP View Gene Set 2.067e-22 178 5.682e-21 87 Genes up-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [Gene ID=10419] by RNAi. www.broad.mit.e...
Broad LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER View Gene Set 2.683e-22 167 7.292e-21 88 Overexpressed genes with amplified copy number across 27 non-small cell lung cancer (NSCLC) cell lines. www.broad.mit.e...
Broad OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP View Gene Set 5.431e-22 114 1.46e-20 89 Genes up-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors. www.broad.mit.e...
Broad KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP View Gene Set 1.699e-21 869 4.515e-20 90 Genes up-regulated in HL-60 cells (acute promyelocytic leukemia APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h. www.broad.mit.e...
Broad STEIN_ESRRA_TARGETS View Gene Set 2.013e-21 508 5.292e-20 91 Genes regulated by ESRRA [Gene ID=2101] in MCF-7 cells (breast cancer). www.broad.mit.e...
Broad ONKEN_UVEAL_MELANOMA_DN View Gene Set 2.233e-21 509 5.806e-20 92 Genes down-regulated in uveal melanoma: class 2 vs class 1 tumors. www.broad.mit.e...
Broad LI_AMPLIFIED_IN_LUNG_CANCER View Gene Set 4.541e-21 165 1.168e-19 93 Genes with increased copy number that correlates with increased expression across six different lung adenocarcinoma cell lines. www.broad.mit.e...
Broad KIM_WT1_TARGETS_DN View Gene Set 4.68e-21 431 1.191e-19 94 Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [Gene ID=7490]. www.broad.mit.e...
Broad MARKEY_RB1_ACUTE_LOF_DN View Gene Set 1.066e-20 201 2.683e-19 95 Genes down-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. www.broad.mit.e...
Broad CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP View Gene Set 1.908e-20 422 4.755e-19 96 Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. www.broad.mit.e...
Broad JISON_SICKLE_CELL_DISEASE_DN View Gene Set 3.365e-20 168 8.299e-19 97 Genes down-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects. www.broad.mit.e...
Broad GOLDRATH_HOMEOSTATIC_PROLIFERATION View Gene Set 7.131e-20 154 1.74e-18 98 Up-regulated in CD8+ [Gene ID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population. www.broad.mit.e...
Broad OSMAN_BLADDER_CANCER_UP View Gene Set 1.155e-19 387 2.791e-18 99 Genes up-regulated in blood samples from bladder cancer patients. www.broad.mit.e...
Broad HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN View Gene Set 2.388e-19 111 5.712e-18 100 Genes down-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. www.broad.mit.e...
Broad PUJANA_BRCA_CENTERED_NETWORK View Gene Set 6.802e-19 92 1.611e-17 101 Genes constituting the BRCA-centered network (BCN). www.broad.mit.e...
Broad WANG_LMO4_TARGETS_UP View Gene Set 2.021e-18 341 4.695e-17 102 Genes up-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [Gene ID=8543] by a Tet Off system. www.broad.mit.e...
Broad MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN View Gene Set 2.022e-18 212 4.695e-17 102 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. www.broad.mit.e...
Broad WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP View Gene Set 2.791e-18 244 6.418e-17 104 Genes up-regulated in mucinous ovarian carcinoma tumors of low malignant potential (LMP) compared to normal ovarian surface epithelium tissue. www.broad.mit.e...
Broad WELCSH_BRCA1_TARGETS_1_DN View Gene Set 4.313e-18 124 9.825e-17 105 Upregulated by induction of exogenous BRCA1 in EcR-293 cells www.broad.mit.e...
Broad MISSIAGLIA_REGULATED_BY_METHYLATION_DN View Gene Set 6.102e-18 96 1.377e-16 106 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668] a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. www.broad.mit.e...
Broad CROONQUIST_IL6_DEPRIVATION_DN View Gene Set 7.54e-18 80 1.686e-16 107 Genes down-regulated in the ANBL-6 cell line (multiple myeloma MM) after withdrawal of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 View Gene Set 8.625e-18 131 1.893e-16 108 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 14. www.broad.mit.e...
Broad LEE_LIVER_CANCER_SURVIVAL_DN View Gene Set 8.584e-18 123 1.893e-16 108 Genes highly expressed in hepatocellular carcinoma with poor survival. www.broad.mit.e...
Broad OSMAN_BLADDER_CANCER_DN View Gene Set 1.204e-17 358 2.619e-16 110 Genes down-regulated in blood samples from bladder cancer patients. www.broad.mit.e...
Broad FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP View Gene Set 1.47e-17 147 3.168e-16 111 Genes upreglated in peripheral blood lymphocytes (PBL) from patients with well functioning kidneys more than 1-year post transplant compared to those from normal living kidney donors. www.broad.mit.e...
Broad KAAB_FAILED_HEART_ATRIUM_DN View Gene Set 1.914e-17 139 4.087e-16 112 Genes down-regulated in atria of failing hearts (DCM and ICM) compared to healthy controls. www.broad.mit.e...
Broad GEORGES_TARGETS_OF_MIR192_AND_MIR215 View Gene Set 2.003e-17 809 4.202e-16 113 Genes down-regulated in HCT116 cells (colon cancer) by expression of MIR192 or MIR215 [Gene ID=406967 406997] at 24 h. www.broad.mit.e...
Broad LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN View Gene Set 1.987e-17 158 4.202e-16 113 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. www.broad.mit.e...
Broad UDAYAKUMAR_MED1_TARGETS_UP View Gene Set 2.207e-17 129 4.59e-16 115 Genes up-regulated in HeLa cells after knockdown of MED1 [Gene ID=5469] by RNAi. www.broad.mit.e...
Broad GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP View Gene Set 3.883e-17 180 7.939e-16 116 Genes up-regulated in quiescent CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. www.broad.mit.e...
Broad PENG_GLUTAMINE_DEPRIVATION_DN View Gene Set 3.87e-17 84 7.939e-16 116 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. www.broad.mit.e...
Broad BASAKI_YBX1_TARGETS_UP View Gene Set 5.723e-17 279 1.16e-15 118 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [Gene ID=4904] knockdown by RNAi. www.broad.mit.e...
Broad ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN View Gene Set 6.3e-17 346 1.266e-15 119 Genes down-regulated in normal tissue adjacent to liver tumor compared to the normal liver samples. www.broad.mit.e...
Broad WANG_SMARCE1_TARGETS_DN View Gene Set 9.2e-17 329 1.834e-15 120 Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [Gene ID=6605] off a retroviral vector. www.broad.mit.e...
Broad YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 View Gene Set 1.227e-16 63 2.426e-15 121 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. www.broad.mit.e...
Broad LIU_PROSTATE_CANCER_UP View Gene Set 1.491e-16 88 2.912e-15 122 Genes up-regulated in prostate cancer samples. www.broad.mit.e...
Broad RHODES_CANCER_META_SIGNATURE View Gene Set 1.497e-16 54 2.912e-15 122 Genes commonly up-regulated in cancer relative to normal tissue according to the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad KANG_DOXORUBICIN_RESISTANCE_UP View Gene Set 1.514e-16 53 2.92e-15 124 Genes differentialy expressed in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive. www.broad.mit.e...
Broad MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP View Gene Set 1.545e-16 359 2.957e-15 125 The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. www.broad.mit.e...
Broad FUJII_YBX1_TARGETS_DN View Gene Set 3.164e-16 139 6.006e-15 126 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [Gene ID=4904] by RNAi. www.broad.mit.e...
Broad STEIN_ESRRA_TARGETS_UP View Gene Set 3.344e-16 368 6.298e-15 127 Genes up-regulated by ESRRA [Gene ID=2101] only. www.broad.mit.e...
Broad SEIDEN_ONCOGENESIS_BY_MET View Gene Set 4.692e-16 83 8.769e-15 128 Genes changed in xenograft tumors formed by DLD-1 or DKO-4 cells (colon cancer) overexpressing MET [Gene ID=4233]. www.broad.mit.e...
Broad CROONQUIST_NRAS_SIGNALING_DN View Gene Set 5.031e-16 62 9.329e-15 129 Genes down-regulated in ANBL-6 cell line (multiple myeloma MM) expressing a constantly active form of NRAS [Gene ID=4893] off a plasmid vector compared to those grown in the presence of IL6 [Gene ID=3569]. www.broad.mit.e...
Broad MILI_PSEUDOPODIA_CHEMOTAXIS_DN View Gene Set 6.237e-16 430 1.148e-14 130 Transcripts depleted in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988]. www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_UP View Gene Set 9.681e-16 301 1.768e-14 131 Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [Gene ID=2071] after UV irradiation. www.broad.mit.e...
Broad ALONSO_METASTASIS_UP View Gene Set 1.671e-15 152 3.028e-14 132 Up-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not. www.broad.mit.e...
Broad BASSO_B_LYMPHOCYTE_NETWORK View Gene Set 1.701e-15 136 3.058e-14 133 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. www.broad.mit.e...
Broad MOOTHA_VOXPHOS View Gene Set 1.831e-15 82 3.269e-14 134 Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. www.broad.mit.e...
Broad NELSON_RESPONSE_TO_ANDROGEN_UP View Gene Set 2.458e-15 81 4.355e-14 135 Genes up-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766]. www.broad.mit.e...
Broad CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP View Gene Set 7.384e-15 51 1.299e-13 136 Protein biosynthesis transport or catabolism genes up-regulated in hyperploid multiple myeloma (MM) compared to the non-hyperploid MM samples. www.broad.mit.e...
Broad TIEN_INTESTINE_PROBIOTICS_6HR_UP View Gene Set 8.47e-15 50 1.479e-13 137 Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 6h. www.broad.mit.e...
Broad AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP View Gene Set 1.009e-14 288 1.749e-13 138 Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens. www.broad.mit.e...
Broad WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP View Gene Set 1.089e-14 99 1.874e-13 139 Genes up-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders). www.broad.mit.e...
Broad SWEET_LUNG_CANCER_KRAS_UP View Gene Set 1.132e-14 436 1.935e-13 140 Genes up-regulated in the mouse lung cancer model with mutated KRAS [Gene ID=3845]. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN View Gene Set 1.167e-14 46 1.979e-13 141 Cluster 6: genes down-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] in combination with serum but not affected by serum alone; they are also up-regulated by MYC alone. www.broad.mit.e...
Broad SCHUHMACHER_MYC_TARGETS_UP View Gene Set 1.211e-14 68 2.039e-13 142 Genes up-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [Gene ID=4609]. www.broad.mit.e...
Broad BENPORATH_ES_1 View Gene Set 1.307e-14 367 2.186e-13 143 Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies. www.broad.mit.e...
Broad WHITEFORD_PEDIATRIC_CANCER_MARKERS View Gene Set 2.146e-14 92 3.565e-13 144 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. www.broad.mit.e...
Broad HOSHIDA_LIVER_CANCER_SUBCLASS_S2 View Gene Set 2.223e-14 114 3.667e-13 145 Genes from 'subtype S2' signature of hepatocellular carcinoma (HCC): proliferation MYC and AKT1 [Gene ID=4609 207] activation. www.broad.mit.e...
Broad ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP View Gene Set 4.156e-14 166 6.809e-13 146 Genes up-regulated in normal tissue adjacent to liver tumor compared to the normal liver samples. www.broad.mit.e...
Broad SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP View Gene Set 4.287e-14 45 6.976e-13 147 Cluster 5: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [Gene ID=4609] alone or in combination with serum but not by serum alone. www.broad.mit.e...
Broad DITTMER_PTHLH_TARGETS_UP View Gene Set 7.539e-14 108 1.218e-12 148 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [Gene ID=5744] by RNAi. www.broad.mit.e...
Broad HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP View Gene Set 7.989e-14 93 1.283e-12 149 Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte. www.broad.mit.e...
Broad CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN View Gene Set 8.677e-14 99 1.384e-12 150 Genes down-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743]. www.broad.mit.e...
Broad SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN View Gene Set 9.729e-14 79 1.541e-12 151 Selected genes down-regulated in inflammatory monocytes infiltrating hepatocellular carcinoma (HCC). www.broad.mit.e...
Broad ELVIDGE_HYPOXIA_DN View Gene Set 1.481e-13 136 2.33e-12 152 Genes down-regulated in MCF7 cells (breast cancer) under hypoxia conditions. www.broad.mit.e...
Broad CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 View Gene Set 1.541e-13 491 2.41e-12 153 The 'group 1 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [Gene ID=2099 2064]. www.broad.mit.e...
Broad FARMER_BREAST_CANCER_APOCRINE_VS_BASAL View Gene Set 1.946e-13 321 3.023e-12 154 Genes which best discriminate between two groups of breast cancer according the status of ESR1 and AR [Gene ID=2099 367]: apocrine (ESR1- AR+) vs basal (ESR1- AR-). www.broad.mit.e...
Broad WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP View Gene Set 2.163e-13 131 3.337e-12 155 Genes up-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue. www.broad.mit.e...
Broad SENESE_HDAC1_TARGETS_UP View Gene Set 3.14e-13 427 4.814e-12 156 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [Gene ID=3065] by RNAi. www.broad.mit.e...
Broad GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN View Gene Set 3.338e-13 86 5.086e-12 157 Genes down-regulated in quiescent vs dividing CD34+ [Gene ID=8842] cells isolated from peripheral blood of normal donors. www.broad.mit.e...
Broad NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN View Gene Set 3.909e-13 583 5.919e-12 158 Down-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPAIR_GENES View Gene Set 4.077e-13 205 6.134e-12 159 Genes involved in DNA repair compiled manually by the authors. www.broad.mit.e...
Broad PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN View Gene Set 4.416e-13 49 6.603e-12 160 Antigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562]. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_LIT_INT_NETWORK View Gene Set 9.113e-13 100 1.354e-11 161 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1 BRCA2 ATM and CHEK2 [Gene ID=672 675 472 11200]; the interactions were manually curated from the literature. www.broad.mit.e...
Broad ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN View Gene Set 9.435e-13 61 1.393e-11 162 Genes down-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562]. www.broad.mit.e...
Broad WELCSH_BRCA1_TARGETS_1_UP View Gene Set 9.605e-13 171 1.41e-11 163 Upregulated by induction of exogenous BRCA1 in EcR-293 cells www.broad.mit.e...
Broad MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN View Gene Set 9.742e-13 121 1.421e-11 164 Genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [Gene ID=23495]. www.broad.mit.e...
Broad ZHANG_RESPONSE_TO_CANTHARIDIN_DN View Gene Set 1.084e-12 60 1.572e-11 165 Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. www.broad.mit.e...
Broad KAUFFMANN_DNA_REPLICATION_GENES View Gene Set 1.096e-12 128 1.58e-11 166 Genes involved in DNA replication compiled manually by the authors. www.broad.mit.e...
Broad BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS View Gene Set 1.27e-12 805 1.819e-11 167 Transcripts in hematopoietic stem cells (HSC) which are trans-regulated (i.e. modulated by a QTL (quantitative trait locus) not in a close proximity to the gene). www.broad.mit.e...
Broad DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN View Gene Set 1.334e-12 418 1.899e-11 168 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [Gene ID=2071] after UVC irradiation. www.broad.mit.e...
Broad ZHAN_MULTIPLE_MYELOMA_PR_UP View Gene Set 1.567e-12 43 2.218e-11 169 Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. www.broad.mit.e...
Broad RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN View Gene Set 1.61e-12 732 2.265e-11 170 Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue. www.broad.mit.e...
Broad BENPORATH_MYC_TARGETS_WITH_EBOX View Gene Set 1.739e-12 229 2.433e-11 171 Set 'Myc targets1': targets of c-Myc [Gene ID=4609] identified by ChIP on chip in cultured cell lines focusing on E-box???containing genes; high affinity bound subset www.broad.mit.e...
Broad FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN View Gene Set 2.022e-12 76 2.811e-11 172 Top 100 genes positively (UP) and negatively (DN) associated with T-cell acute lymphoblastic leukemia MLL T-ALL) expressing MLL-ENL fusion [Gene ID=4297 4298]. www.broad.mit.e...
Broad AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN View Gene Set 2.103e-12 218 2.908e-11 173 Down-regulated genes whose expression correlates with copy number losses in pancreatic adenocarcinoma cell lines and primary tumor specimens. www.broad.mit.e...
Broad IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR View Gene Set 2.52e-12 100 3.464e-11 174 Genes in the expression cluster 'Early Progenitors Shared': up-regulated in hematopoietic progenitors from adult bone marrow and from fetal liver. www.broad.mit.e...
Broad SESTO_RESPONSE_TO_UV_C0 View Gene Set 2.823e-12 106 3.858e-11 175 Cluster 0: genes changed in primary keratinocytes by UVB irradiation. www.broad.mit.e...
Broad NAKAMURA_CANCER_MICROENVIRONMENT_DN View Gene Set 2.884e-12 45 3.92e-11 176 Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. www.broad.mit.e...
Broad MORI_LARGE_PRE_BII_LYMPHOCYTE_UP View Gene Set 4.63e-12 52 6.258e-11 177 Up-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage. www.broad.mit.e...
Broad VANTVEER_BREAST_CANCER_METASTASIS_DN View Gene Set 5.366e-12 104 7.211e-11 178 Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). www.broad.mit.e...
Broad PROVENZANI_METASTASIS_UP View Gene Set 5.813e-12 188 7.769e-11 179 Genes up-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma CRC) compared to the SW620 cells (lymph node metastasis from the same individual). www.broad.mit.e...
Broad RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP View Gene Set 5.969e-12 220 7.932e-11 180 Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors. www.broad.mit.e...
Broad FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP View Gene Set 8.663e-12 61 1.145e-10 181 Genes diffierentially expressed in peripheral blood lymphocytes (PBL) from patients with acute transplant rejection compared to those from patients with well functioning kidneys more than 1-year post transplant. www.broad.mit.e...
Broad HAMAI_APOPTOSIS_VIA_TRAIL_UP View Gene Set 9.35e-12 328 1.229e-10 182 Genes up-regulated in T1 cells (primary melanoma sensitive to TRAIL [Gene ID=8743]) compared to G1 cells (metastatic melanoma resistant to TRAIL). www.broad.mit.e...
Broad RHODES_UNDIFFERENTIATED_CANCER View Gene Set 1.106e-11 60 1.445e-10 183 Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer based on the meta-analysis of the OncoMine gene expression database. www.broad.mit.e...
Broad PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP View Gene Set 1.271e-11 53 1.652e-10 184 The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [Gene ID=672] compared to those with the wild type allele. www.broad.mit.e...
Broad REN_BOUND_BY_E2F View Gene Set 1.652e-11 47 2.136e-10 185 Genes whose promoters were bound by E2F1 [Gene ID=1869] and E2F4 [Gene ID=1874] in the primary fibroblasts WI-38 by ChIP on chip assay. www.broad.mit.e...
Broad MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN View Gene Set 1.674e-11 42 2.153e-10 186 Genes down-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI [Gene ID=23495]. www.broad.mit.e...
Broad SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP View Gene Set 1.902e-11 45 2.433e-10 187 Top 50 up-regulated markers distinguishing diffuse large B-cell lymphoma (DLBCL) from follicular lymphoma (FL) samples. www.broad.mit.e...
Broad ENK_UV_RESPONSE_KERATINOCYTE_UP View Gene Set 2.646e-11 517 3.367e-10 188 Genes up-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. www.broad.mit.e...
Broad FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN View Gene Set 2.867e-11 43 3.628e-10 189 Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen raloxifene or ICI 182780 but not by estradiol [PubChem=44959 5035 3478439 5757]. www.broad.mit.e...
Broad SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC View Gene Set 3.383e-11 101 4.26e-10 190 Cluster 2: genes up-regulated in B493-6 cells (B lymphocytes) by serum alone or in combination with MYC [Gene ID=4609] but not by MYC alone. www.broad.mit.e...
Broad SONG_TARGETS_OF_IE86_CMV_PROTEIN View Gene Set 5.85e-11 49 7.326e-10 191 Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector. www.broad.mit.e...
Broad LANDIS_ERBB2_BREAST_TUMORS_324_UP View Gene Set 6.876e-11 132 8.566e-10 192 The 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [Gene ID=2064]. www.broad.mit.e...
Broad CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP View Gene Set 7.244e-11 135 8.978e-10 193 Genes up-regulated in CD4+ [Gene ID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360]. www.broad.mit.e...
Broad WANG_LMO4_TARGETS_DN View Gene Set 1.125e-10 327 1.387e-09 194 Genes down-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [Gene ID=8543] by a Tet Off system. www.broad.mit.e...
Broad LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q View Gene Set 1.314e-10 106 1.612e-09 195 Genes down-regulated in urothelial cell carcinoma (UCC) tumors with LOH on 9q as compared to the tumors showing retention. www.broad.mit.e...
Broad POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN View Gene Set 1.342e-10 39 1.638e-09 196 Top marker genes in medulloblastoma associated with poor response to treatment (poor outcome). www.broad.mit.e...
Broad BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN View Gene Set 1.882e-10 164 2.285e-09 197 Genes down-regulated in patients at the incipient stage of Alzheimer's disease. www.broad.mit.e...
Broad SMITH_TERT_TARGETS_UP View Gene Set 2.028e-10 128 2.45e-09 198 Genes consistently up-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [Gene ID=7015] off a retroviral vector. www.broad.mit.e...
Broad PENG_RAPAMYCIN_RESPONSE_DN View Gene Set 2.222e-10 69 2.671e-09 199 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. www.broad.mit.e...
Broad YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP View Gene Set 2.244e-10 46 2.684e-09 200 Up-regulated genes distinguishing hepatocellular carcinoma (HCC) samples positive for EPCAM [Gene ID=4072] from the negative ones. www.broad.mit.e...

Gene Set Collection: Broad.c2.CP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad SA_G1_AND_S_PHASES View Gene Set 2.412e-06 15 0.0001134 1 Cdk2 4 and 6 bind cyclin D in G1 while cdk2/cyclin E promotes the G1/S transition. www.broad.mit.e...
Broad SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES View Gene Set 3.257e-05 49 0.0007654 2 Genes related to the insulin receptor pathway www.broad.mit.e...
Broad SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES View Gene Set 7.976e-05 63 0.00125 3 Genes related to PIP3 signaling in cardiac myocytes www.broad.mit.e...
Broad ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY View Gene Set 0.0003155 34 0.003707 4 PI3K Pathway www.broad.mit.e...
Broad SA_PTEN_PATHWAY View Gene Set 0.001061 16 0.009975 5 PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. www.broad.mit.e...
Broad SA_REG_CASCADE_OF_CYCLIN_EXPR View Gene Set 0.001745 13 0.01367 6 Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. www.broad.mit.e...
Broad SIG_CHEMOTAXIS View Gene Set 0.002747 44 0.01845 7 Genes related to chemotaxis www.broad.mit.e...
Broad ST_G_ALPHA_S_PATHWAY View Gene Set 0.005701 12 0.03349 8 G alpha s Pathway www.broad.mit.e...
Broad ST_GA13_PATHWAY View Gene Set 0.007895 35 0.04123 9 G alpha 13 Pathway www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.BIOCARTA

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad BIOCARTA_RACCYCD_PATHWAY View Gene Set 2.768e-08 26 6.006e-06 1 Influence of Ras and Rho proteins on G1 to S Transition www.broad.mit.e...
Broad BIOCARTA_EIF_PATHWAY View Gene Set 4.291e-07 16 3.954e-05 2 Eukaryotic protein translation www.broad.mit.e...
Broad BIOCARTA_MTOR_PATHWAY View Gene Set 5.467e-07 23 3.954e-05 2 mTOR Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_PROTEASOME_PATHWAY View Gene Set 1.651e-06 19 8.956e-05 4 Proteasome Complex www.broad.mit.e...
Broad BIOCARTA_P27_PATHWAY View Gene Set 2.914e-06 13 0.0001265 5 Regulation of p27 Phosphorylation during Cell Cycle Progression www.broad.mit.e...
Broad BIOCARTA_AKAP95_PATHWAY View Gene Set 1.57e-05 12 0.0004868 6 AKAP95 role in mitosis and chromosome dynamics www.broad.mit.e...
Broad BIOCARTA_IGF1MTOR_PATHWAY View Gene Set 1.498e-05 20 0.0004868 6 Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway www.broad.mit.e...
Broad BIOCARTA_G1_PATHWAY View Gene Set 2.648e-05 28 0.0007183 8 Cell Cycle: G1/S Check Point www.broad.mit.e...
Broad BIOCARTA_G2_PATHWAY View Gene Set 6.091e-05 24 0.001469 9 Cell Cycle: G2/M Checkpoint www.broad.mit.e...
Broad BIOCARTA_RAS_PATHWAY View Gene Set 9.994e-05 23 0.002169 10 Ras Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_ARF_PATHWAY View Gene Set 0.0001201 17 0.002369 11 Tumor Suppressor Arf Inhibits Ribosomal Biogenesis www.broad.mit.e...
Broad BIOCARTA_RANMS_PATHWAY View Gene Set 0.0001414 10 0.002556 12 Role of Ran in mitotic spindle regulation www.broad.mit.e...
Broad BIOCARTA_EIF4_PATHWAY View Gene Set 0.0001825 24 0.003046 13 Regulation of eIF4e and p70 S6 Kinase www.broad.mit.e...
Broad BIOCARTA_IGF1R_PATHWAY View Gene Set 0.0001976 23 0.003063 14 Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation www.broad.mit.e...
Broad BIOCARTA_MCM_PATHWAY View Gene Set 0.0002328 18 0.003157 15 CDK Regulation of DNA Replication www.broad.mit.e...
Broad BIOCARTA_EIF2_PATHWAY View Gene Set 0.0002283 11 0.003157 15 Regulation of eIF2 www.broad.mit.e...
Broad BIOCARTA_CDC42RAC_PATHWAY View Gene Set 0.0002823 16 0.003603 17 Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration www.broad.mit.e...
Broad BIOCARTA_RB_PATHWAY View Gene Set 0.0003236 13 0.003901 18 RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage www.broad.mit.e...
Broad BIOCARTA_CELLCYCLE_PATHWAY View Gene Set 0.0003492 23 0.003988 19 Cyclins and Cell Cycle Regulation www.broad.mit.e...
Broad BIOCARTA_CHREBP2_PATHWAY View Gene Set 0.000394 42 0.004275 20 Regulation And Function Of ChREBP in Liver www.broad.mit.e...
Broad BIOCARTA_RHO_PATHWAY View Gene Set 0.0006252 32 0.006461 21 Rho cell motility signaling pathway www.broad.mit.e...
Broad BIOCARTA_GLYCOLYSIS_PATHWAY View Gene Set 0.000705 10 0.006954 22 Glycolysis Pathway www.broad.mit.e...
Broad BIOCARTA_VDR_PATHWAY View Gene Set 0.0009793 12 0.008631 23 Control of Gene Expression by Vitamin D Receptor www.broad.mit.e...
Broad BIOCARTA_ERK_PATHWAY View Gene Set 0.0009944 28 0.008631 23 Erk1/Erk2 Mapk Signaling pathway www.broad.mit.e...
Broad BIOCARTA_CREB_PATHWAY View Gene Set 0.0009532 27 0.008631 23 Transcription factor CREB and its extracellular signals www.broad.mit.e...
Broad BIOCARTA_MPR_PATHWAY View Gene Set 0.00106 34 0.008847 26 How Progesterone Initiates Oocyte Membrane www.broad.mit.e...
Broad BIOCARTA_KREB_PATHWAY View Gene Set 0.001223 8 0.00983 27 The Citric Acid Cycle www.broad.mit.e...
Broad BIOCARTA_RNA_PATHWAY View Gene Set 0.001705 10 0.01252 28 Double Stranded RNA Induced Gene Expression www.broad.mit.e...
Broad BIOCARTA_AKAPCENTROSOME_PATHWAY View Gene Set 0.00173 15 0.01252 28 Protein Kinase A at the Centrosome www.broad.mit.e...
Broad BIOCARTA_ATRBRCA_PATHWAY View Gene Set 0.001726 21 0.01252 28 Role of BRCA1 BRCA2 and ATR in Cancer Susceptibility www.broad.mit.e...
Broad BIOCARTA_ECM_PATHWAY View Gene Set 0.002055 24 0.01436 31 Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia www.broad.mit.e...
Broad BIOCARTA_EGFR_SMRTE_PATHWAY View Gene Set 0.002184 11 0.01436 31 Map Kinase Inactivation of SMRT Corepressor www.broad.mit.e...
Broad BIOCARTA_P53_PATHWAY View Gene Set 0.002167 16 0.01436 31 p53 Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_AKAP13_PATHWAY View Gene Set 0.002429 12 0.0155 34 Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation www.broad.mit.e...
Broad BIOCARTA_MAPK_PATHWAY View Gene Set 0.002598 87 0.01611 35 MAPKinase Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_SRCRPTP_PATHWAY View Gene Set 0.003046 11 0.0171 36 Activation of Src by Protein-tyrosine phosphatase alpha www.broad.mit.e...
Broad BIOCARTA_TEL_PATHWAY View Gene Set 0.002849 18 0.0171 36 Telomeres Telomerase Cellular Aging and Immortality www.broad.mit.e...
Broad BIOCARTA_TFF_PATHWAY View Gene Set 0.003073 21 0.0171 36 Trefoil Factors Initiate Mucosal Healing www.broad.mit.e...
Broad BIOCARTA_VEGF_PATHWAY View Gene Set 0.003036 29 0.0171 36 VEGF Hypoxia and Angiogenesis www.broad.mit.e...
Broad BIOCARTA_MCALPAIN_PATHWAY View Gene Set 0.003734 25 0.01976 40 mCalpain and friends in Cell motility www.broad.mit.e...
Broad BIOCARTA_PTEN_PATHWAY View Gene Set 0.003658 18 0.01976 40 PTEN dependent cell cycle arrest and apoptosis www.broad.mit.e...
Broad BIOCARTA_SKP2E2F_PATHWAY View Gene Set 0.003941 10 0.02036 42 E2F1 Destruction Pathway www.broad.mit.e...
Broad BIOCARTA_ACTINY_PATHWAY View Gene Set 0.004679 20 0.02361 43 Y branching of actin filaments www.broad.mit.e...
Broad BIOCARTA_WNT_PATHWAY View Gene Set 0.005242 26 0.02585 44 WNT Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_BCELLSURVIVAL_PATHWAY View Gene Set 0.005666 16 0.02622 45 B Cell Survival Pathway www.broad.mit.e...
Broad BIOCARTA_HCMV_PATHWAY View Gene Set 0.005678 17 0.02622 45 Human Cytomegalovirus and Map Kinase Pathways www.broad.mit.e...
Broad BIOCARTA_HER2_PATHWAY View Gene Set 0.005547 22 0.02622 45 Role of ERBB2 in Signal Transduction and Oncology www.broad.mit.e...
Broad BIOCARTA_SALMONELLA_PATHWAY View Gene Set 0.007047 13 0.03058 48 How does salmonella hijack a cell www.broad.mit.e...
Broad BIOCARTA_PTC1_PATHWAY View Gene Set 0.006968 11 0.03058 48 Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle www.broad.mit.e...
Broad BIOCARTA_SARS_PATHWAY View Gene Set 0.006811 10 0.03058 48 The SARS-coronavirus Life Cycle www.broad.mit.e...
Broad BIOCARTA_CK1_PATHWAY View Gene Set 0.009173 17 0.03903 51 Regulation of ck1/cdk5 by type 1 glutamate receptors www.broad.mit.e...
Broad BIOCARTA_CERAMIDE_PATHWAY View Gene Set 0.009434 22 0.03933 52 Ceramide Signaling Pathway www.broad.mit.e...
Broad BIOCARTA_GCR_PATHWAY View Gene Set 0.009607 20 0.03933 52 Corticosteroids and cardioprotection www.broad.mit.e...
Broad BIOCARTA_MET_PATHWAY View Gene Set 0.01035 37 0.04161 54 Signaling of Hepatocyte Growth Factor Receptor www.broad.mit.e...
Broad BIOCARTA_CCR3_PATHWAY View Gene Set 0.01116 23 0.04333 55 CCR3 signaling in Eosinophils www.broad.mit.e...
Broad BIOCARTA_ETC_PATHWAY View Gene Set 0.01118 12 0.04333 55 Electron Transport Reaction in Mitochondria www.broad.mit.e...
Broad BIOCARTA_RAB_PATHWAY View Gene Set 0.01175 12 0.04474 57 Rab GTPases Mark Targets In The Endocytotic Machinery www.broad.mit.e...
Broad BIOCARTA_P35ALZHEIMERS_PATHWAY View Gene Set 0.01223 11 0.04574 58 Deregulation of CDK5 in Alzheimers Disease www.broad.mit.e...
Broad BIOCARTA_CHEMICAL_PATHWAY View Gene Set 0.01267 22 0.04661 59 Apoptotic Signaling in Response to DNA Damage www.broad.mit.e...
Broad BIOCARTA_PTDINS_PATHWAY View Gene Set 0.01329 23 0.04727 60 Phosphoinositides and their downstream targets. www.broad.mit.e...
Broad BIOCARTA_NKCELLS_PATHWAY View Gene Set 0.01312 20 0.04727 60 Ras-Independent pathway in NK cell-mediated cytotoxicity www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.KEGG

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad KEGG_RIBOSOME View Gene Set 1.053e-25 88 1.958e-23 1 Ribosome www.broad.mit.e...
Broad KEGG_SPLICEOSOME View Gene Set 2.743e-16 118 2.551e-14 2 Spliceosome www.broad.mit.e...
Broad KEGG_CELL_CYCLE View Gene Set 1.503e-15 128 9.316e-14 3 Cell cycle www.broad.mit.e...
Broad KEGG_OXIDATIVE_PHOSPHORYLATION View Gene Set 3.557e-12 135 1.654e-10 4 Oxidative phosphorylation www.broad.mit.e...
Broad KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS View Gene Set 1.292e-10 138 4.805e-09 5 Ubiquitin mediated proteolysis www.broad.mit.e...
Broad KEGG_PYRIMIDINE_METABOLISM View Gene Set 1.566e-10 98 4.856e-09 6 Pyrimidine metabolism www.broad.mit.e...
Broad KEGG_HUNTINGTONS_DISEASE View Gene Set 2.351e-10 185 6.248e-09 7 Huntington's disease www.broad.mit.e...
Broad KEGG_RNA_DEGRADATION View Gene Set 3.206e-10 59 7.454e-09 8 RNA degradation www.broad.mit.e...
Broad KEGG_PARKINSONS_DISEASE View Gene Set 3.986e-09 133 8.239e-08 9 Parkinson's disease www.broad.mit.e...
Broad KEGG_ALZHEIMERS_DISEASE View Gene Set 5.814e-09 169 1.081e-07 10 Alzheimer's disease www.broad.mit.e...
Broad KEGG_PROTEASOME View Gene Set 2.783e-08 48 4.705e-07 11 Proteasome www.broad.mit.e...
Broad KEGG_OOCYTE_MEIOSIS View Gene Set 7.883e-08 114 1.222e-06 12 Oocyte meiosis www.broad.mit.e...
Broad KEGG_AMINOACYL_TRNA_BIOSYNTHESIS View Gene Set 9.561e-08 41 1.368e-06 13 Aminoacyl-tRNA biosynthesis www.broad.mit.e...
Broad KEGG_PROTEIN_EXPORT View Gene Set 2.231e-07 24 2.964e-06 14 Protein export www.broad.mit.e...
Broad KEGG_DNA_REPLICATION View Gene Set 3.726e-07 36 4.62e-06 15 DNA replication www.broad.mit.e...
Broad KEGG_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 1.498e-06 44 1.741e-05 16 Nucleotide excision repair www.broad.mit.e...
Broad KEGG_CITRATE_CYCLE_TCA_CYCLE View Gene Set 1.662e-06 32 1.819e-05 17 Citrate cycle (TCA cycle) www.broad.mit.e...
Broad KEGG_PROSTATE_CANCER View Gene Set 2.258e-06 89 2.333e-05 18 Prostate cancer www.broad.mit.e...
Broad KEGG_CHRONIC_MYELOID_LEUKEMIA View Gene Set 2.457e-06 73 2.406e-05 19 Chronic myeloid leukemia www.broad.mit.e...
Broad KEGG_BASE_EXCISION_REPAIR View Gene Set 1.029e-05 35 9.116e-05 20 Base excision repair www.broad.mit.e...
Broad KEGG_MTOR_SIGNALING_PATHWAY View Gene Set 1.01e-05 52 9.116e-05 20 mTOR signaling pathway www.broad.mit.e...
Broad KEGG_CYSTEINE_AND_METHIONINE_METABOLISM View Gene Set 2.633e-05 34 0.0002226 22 Cysteine and methionine metabolism www.broad.mit.e...
Broad KEGG_PANCREATIC_CANCER View Gene Set 2.764e-05 70 0.0002235 23 Pancreatic cancer www.broad.mit.e...
Broad KEGG_N_GLYCAN_BIOSYNTHESIS View Gene Set 3.053e-05 46 0.0002366 24 N-Glycan biosynthesis www.broad.mit.e...
Broad KEGG_SMALL_CELL_LUNG_CANCER View Gene Set 6.741e-05 84 0.0005015 25 Small cell lung cancer www.broad.mit.e...
Broad KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION View Gene Set 7.407e-05 86 0.0005299 26 Progesterone-mediated oocyte maturation www.broad.mit.e...
Broad KEGG_PEROXISOME View Gene Set 9.992e-05 78 0.0006409 27 Peroxisome www.broad.mit.e...
Broad KEGG_APOPTOSIS View Gene Set 9.881e-05 88 0.0006409 27 Apoptosis www.broad.mit.e...
Broad KEGG_NON_SMALL_CELL_LUNG_CANCER View Gene Set 9.437e-05 54 0.0006409 27 Non-small cell lung cancer www.broad.mit.e...
Broad KEGG_BLADDER_CANCER View Gene Set 0.0001514 42 0.0009388 30 Bladder cancer www.broad.mit.e...
Broad KEGG_PURINE_METABOLISM View Gene Set 0.0003428 157 0.002057 31 Purine metabolism www.broad.mit.e...
Broad KEGG_MISMATCH_REPAIR View Gene Set 0.0004161 23 0.002419 32 Mismatch repair www.broad.mit.e...
Broad KEGG_LYSINE_DEGRADATION View Gene Set 0.0004499 44 0.002471 33 Lysine degradation www.broad.mit.e...
Broad KEGG_LYSOSOME View Gene Set 0.0004517 122 0.002471 33 Lysosome www.broad.mit.e...
Broad KEGG_ENDOMETRIAL_CANCER View Gene Set 0.0004858 52 0.002582 35 Endometrial cancer www.broad.mit.e...
Broad KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION View Gene Set 0.0006568 44 0.003393 36 Vasopressin-regulated water reabsorption www.broad.mit.e...
Broad KEGG_ACUTE_MYELOID_LEUKEMIA View Gene Set 0.0007613 60 0.003827 37 Acute myeloid leukemia www.broad.mit.e...
Broad KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS View Gene Set 0.00167 11 0.008176 38 Valine leucine and isoleucine biosynthesis www.broad.mit.e...
Broad KEGG_GLIOMA View Gene Set 0.001772 65 0.008319 39 Glioma www.broad.mit.e...
Broad KEGG_THYROID_CANCER View Gene Set 0.001789 29 0.008319 39 Thyroid cancer www.broad.mit.e...
Broad KEGG_ONE_CARBON_POOL_BY_FOLATE View Gene Set 0.001855 17 0.008417 41 One carbon pool by folate www.broad.mit.e...
Broad KEGG_ARGININE_AND_PROLINE_METABOLISM View Gene Set 0.001947 54 0.008621 42 Arginine and proline metabolism www.broad.mit.e...
Broad KEGG_RENAL_CELL_CARCINOMA View Gene Set 0.002648 70 0.01145 43 Renal cell carcinoma www.broad.mit.e...
Broad KEGG_RNA_POLYMERASE View Gene Set 0.002712 29 0.01146 44 RNA polymerase www.broad.mit.e...
Broad KEGG_STEROID_BIOSYNTHESIS View Gene Set 0.003345 17 0.01353 45 Steroid biosynthesis www.broad.mit.e...
Broad KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS View Gene Set 0.003276 25 0.01353 45 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis www.broad.mit.e...
Broad KEGG_PYRUVATE_METABOLISM View Gene Set 0.003783 40 0.01497 47 Pyruvate metabolism www.broad.mit.e...
Broad KEGG_INSULIN_SIGNALING_PATHWAY View Gene Set 0.004545 137 0.01761 48 Insulin signaling pathway www.broad.mit.e...
Broad KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION View Gene Set 0.005516 44 0.02094 49 Valine leucine and isoleucine degradation www.broad.mit.e...
Broad KEGG_GLYCOLYSIS_GLUCONEOGENESIS View Gene Set 0.00604 62 0.02247 50 Glycolysis / Gluconeogenesis www.broad.mit.e...
Broad KEGG_MELANOMA View Gene Set 0.006714 71 0.02449 51 Melanoma www.broad.mit.e...
Broad KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM View Gene Set 0.006995 41 0.02502 52 Porphyrin and chlorophyll metabolism www.broad.mit.e...
Broad KEGG_NEUROTROPHIN_SIGNALING_PATHWAY View Gene Set 0.007652 126 0.02685 53 Neurotrophin signaling pathway www.broad.mit.e...
Broad KEGG_HOMOLOGOUS_RECOMBINATION View Gene Set 0.008096 28 0.02789 54 Homologous recombination www.broad.mit.e...
Broad KEGG_SELENOAMINO_ACID_METABOLISM View Gene Set 0.01025 26 0.03405 55 Selenoamino acid metabolism www.broad.mit.e...
Broad KEGG_ENDOCYTOSIS View Gene Set 0.01013 183 0.03405 55 Endocytosis www.broad.mit.e...
Broad KEGG_VIBRIO_CHOLERAE_INFECTION View Gene Set 0.01129 56 0.03683 57 Vibrio cholerae infection www.broad.mit.e...
Broad KEGG_PROPANOATE_METABOLISM View Gene Set 0.01447 33 0.0464 58 Propanoate metabolism www.broad.mit.e...
Broad KEGG_PATHWAYS_IN_CANCER View Gene Set 0.01499 328 0.04725 59 Pathways in cancer www.broad.mit.e...
Broad KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM View Gene Set 0.01627 44 0.05 60 Amino sugar and nucleotide sugar metabolism www.broad.mit.e...
Broad KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS View Gene Set 0.0164 97 0.05 60 Fc gamma R-mediated phagocytosis www.broad.mit.e...

Gene Set Collection: Broad.c2.CP.REACTOME

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad REACTOME_GENE_EXPRESSION View Gene Set 3.961e-52 415 1.703e-49 1 Genes involved in Gene Expression www.broad.mit.e...
Broad REACTOME_TRANSLATION View Gene Set 1.619e-35 120 3.48e-33 2 Genes involved in Translation www.broad.mit.e...
Broad REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT View Gene Set 2.526e-31 106 2.716e-29 3 Genes involved in GTP hydrolysis and joining of the 60S ribosomal subunit www.broad.mit.e...
Broad REACTOME_INFLUENZA_LIFE_CYCLE View Gene Set 1.999e-31 137 2.716e-29 3 Genes involved in Influenza Life Cycle www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_PROTEINS View Gene Set 3.186e-30 215 2.74e-28 5 Genes involved in Metabolism of proteins www.broad.mit.e...
Broad REACTOME_DIABETES_PATHWAYS View Gene Set 3.92e-30 383 2.81e-28 6 Genes involved in Diabetes pathways www.broad.mit.e...
Broad REACTOME_CELL_CYCLE_MITOTIC View Gene Set 1.319e-28 306 8.105e-27 7 Genes involved in Cell Cycle Mitotic www.broad.mit.e...
Broad REACTOME_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS View Gene Set 3.299e-28 95 1.773e-26 8 Genes involved in Formation of a pool of free 40S subunits www.broad.mit.e...
Broad REACTOME_PEPTIDE_CHAIN_ELONGATION View Gene Set 3.921e-26 84 1.873e-24 9 Genes involved in Peptide chain elongation www.broad.mit.e...
Broad REACTOME_INSULIN_SYNTHESIS_AND_SECRETION View Gene Set 1.918e-25 129 8.249e-24 10 Genes involved in Insulin Synthesis and Secretion www.broad.mit.e...
Broad REACTOME_VIRAL_MRNA_TRANSLATION View Gene Set 3.18e-25 84 1.243e-23 11 Genes involved in Viral mRNA Translation www.broad.mit.e...
Broad REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION View Gene Set 8.715e-25 100 2.974e-23 12 Genes involved in Influenza Viral RNA Transcription and Replication www.broad.mit.e...
Broad REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA View Gene Set 8.991e-25 128 2.974e-23 12 Genes involved in Processing of Capped Intron-Containing Pre-mRNA www.broad.mit.e...
Broad REACTOME_ELONGATION_AND_PROCESSING_OF_CAPPED_TRANSCRIPTS View Gene Set 3.252e-21 124 9.989e-20 14 Genes involved in Elongation and Processing of Capped Transcripts www.broad.mit.e...
Broad REACTOME_MITOTIC_M_M_G1_PHASES View Gene Set 4.51e-21 157 1.293e-19 15 Genes involved in Mitotic M-M/G1 phases www.broad.mit.e...
Broad REACTOME_FORMATION_AND_MATURATION_OF_MRNA_TRANSCRIPT View Gene Set 9.53e-21 142 2.561e-19 16 Genes involved in Formation and Maturation of mRNA Transcript www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_RNA View Gene Set 4.734e-20 95 1.197e-18 17 Genes involved in Metabolism of RNA www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING View Gene Set 1.231e-19 97 2.94e-18 18 Genes involved in mRNA Splicing www.broad.mit.e...
Broad REACTOME_TRANSLATION_INITIATION_COMPLEX_FORMATION View Gene Set 2.438e-18 56 5.517e-17 19 Genes involved in Translation initiation complex formation www.broad.mit.e...
Broad REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS View Gene Set 4.198e-18 101 9.025e-17 20 Genes involved in Regulation of gene expression in beta cells www.broad.mit.e...
Broad REACTOME_CELL_CYCLE_CHECKPOINTS View Gene Set 1.739e-17 110 3.561e-16 21 Genes involved in Cell Cycle Checkpoints www.broad.mit.e...
Broad REACTOME_HIV_INFECTION View Gene Set 4.875e-17 183 9.529e-16 22 Genes involved in HIV Infection www.broad.mit.e...
Broad REACTOME_G1_S_TRANSITION View Gene Set 5.768e-17 102 1.078e-15 23 Genes involved in G1/S Transition www.broad.mit.e...
Broad REACTOME_S_PHASE View Gene Set 6.022e-17 103 1.079e-15 24 Genes involved in S Phase www.broad.mit.e...
Broad REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS View Gene Set 6.878e-15 120 1.183e-13 25 Genes involved in Host Interactions of HIV factors www.broad.mit.e...
Broad REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX View Gene Set 8.269e-15 49 1.368e-13 26 Genes involved in Formation of the ternary complex and subsequently the 43S complex www.broad.mit.e...
Broad REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT View Gene Set 3.701e-14 114 5.894e-13 27 Genes involved in Regulation of beta-cell development www.broad.mit.e...
Broad REACTOME_GLUCOSE_REGULATION_OF_INSULIN_SECRETION View Gene Set 9.469e-14 161 1.454e-12 28 Genes involved in Glucose Regulation of Insulin Secretion www.broad.mit.e...
Broad REACTOME_INTEGRATION_OF_ENERGY_METABOLISM View Gene Set 2.372e-13 229 3.517e-12 29 Genes involved in Integration of energy metabolism www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_DNA View Gene Set 7.208e-13 89 1.033e-11 30 Genes involved in Synthesis of DNA www.broad.mit.e...
Broad REACTOME_ELECTRON_TRANSPORT_CHAIN View Gene Set 1.788e-12 75 2.481e-11 31 Genes involved in Electron Transport Chain www.broad.mit.e...
Broad REACTOME_DNA_REPLICATION_PRE_INITIATION View Gene Set 2.035e-12 76 2.735e-11 32 Genes involved in DNA Replication Pre-Initiation www.broad.mit.e...
Broad REACTOME_M_G1_TRANSITION View Gene Set 3.789e-12 61 4.937e-11 33 Genes involved in M/G1 Transition www.broad.mit.e...
Broad REACTOME_REGULATION_OF_APC_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE View Gene Set 8.298e-12 71 1.049e-10 34 Genes involved in Regulation of APC/C activators between G1/S and early anaphase www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_MRNA View Gene Set 4.789e-11 45 5.884e-10 35 Genes involved in Metabolism of mRNA www.broad.mit.e...
Broad REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ View Gene Set 5.861e-11 58 7e-10 36 Genes involved in Cyclin E associated events during G1/S transition www.broad.mit.e...
Broad REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A View Gene Set 7.773e-11 63 9.034e-10 37 Genes involved in Cdc20:Phospho-APC/C mediated degradation of Cyclin A www.broad.mit.e...
Broad REACTOME_SNRNP_ASSEMBLY View Gene Set 8.882e-11 50 1.005e-09 38 Genes involved in snRNP Assembly www.broad.mit.e...
Broad REACTOME_MITOTIC_PROMETAPHASE View Gene Set 1.367e-10 92 1.507e-09 39 Genes involved in Mitotic Prometaphase www.broad.mit.e...
Broad REACTOME_ORC1_REMOVAL_FROM_CHROMATIN View Gene Set 2.261e-10 63 2.431e-09 40 Genes involved in Orc1 removal from chromatin www.broad.mit.e...
Broad REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION View Gene Set 2.687e-10 23 2.819e-09 41 Genes involved in Cytosolic tRNA aminoacylation www.broad.mit.e...
Broad REACTOME_HIV_LIFE_CYCLE View Gene Set 2.909e-10 103 2.978e-09 42 Genes involved in HIV Life Cycle www.broad.mit.e...
Broad REACTOME_METABLISM_OF_NUCLEOTIDES View Gene Set 3.158e-10 71 3.158e-09 43 Genes involved in Metablism of nucleotides www.broad.mit.e...
Broad REACTOME_REGULATION_OF_INSULIN_SECRETION View Gene Set 3.676e-10 212 3.592e-09 44 Genes involved in Regulation of Insulin Secretion www.broad.mit.e...
Broad REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE View Gene Set 2.392e-09 90 2.286e-08 45 Genes involved in Late Phase of HIV Life Cycle www.broad.mit.e...
Broad REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 View Gene Set 3.069e-09 52 2.869e-08 46 Genes involved in SCF(Skp2)-mediated degradation of p2721 www.broad.mit.e...
Broad REACTOME_MEMBRANE_TRAFFICKING View Gene Set 3.533e-09 78 3.232e-08 47 Genes involved in Membrane Trafficking www.broad.mit.e...
Broad REACTOME_SIGNALING_BY_WNT View Gene Set 5.123e-09 58 4.589e-08 48 Genes involved in Signaling by Wnt www.broad.mit.e...
Broad REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC View Gene Set 5.653e-09 57 4.961e-08 49 Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRON_CONTAINING_TRANSCRIPT View Gene Set 5.825e-09 42 5.01e-08 50 Genes involved in Transport of Mature mRNA derived from an Intron-Containing Transcript www.broad.mit.e...
Broad REACTOME_STABILIZATION_OF_P53 View Gene Set 8.257e-09 46 6.962e-08 51 Genes involved in Stabilization of p53 www.broad.mit.e...
Broad REACTOME_TRNA_AMINOACYLATION View Gene Set 9.766e-09 40 8.076e-08 52 Genes involved in tRNA Aminoacylation www.broad.mit.e...
Broad REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX View Gene Set 1.016e-08 52 8.241e-08 53 Genes involved in CDT1 association with the CDC6:ORC:origin complex www.broad.mit.e...
Broad REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G View Gene Set 1.075e-08 47 8.56e-08 54 Genes involved in Vif-mediated degradation of APOBEC3G www.broad.mit.e...
Broad REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE View Gene Set 1.2e-08 47 9.383e-08 55 Genes involved in Regulation of ornithine decarboxylase (ODC) www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION View Gene Set 2.715e-08 188 2.084e-07 56 Genes involved in Transcription www.broad.mit.e...
Broad REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE View Gene Set 2.933e-08 43 2.212e-07 57 Genes involved in p53-Independent DNA Damage Response www.broad.mit.e...
Broad REACTOME_DNA_REPAIR View Gene Set 3.31e-08 102 2.454e-07 58 Genes involved in DNA Repair www.broad.mit.e...
Broad REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 View Gene Set 4.239e-08 48 3.09e-07 59 Genes involved in SCF-beta-TrCP mediated degradation of Emi1 www.broad.mit.e...
Broad REACTOME_DEADENYLATION_OF_MRNA View Gene Set 6.814e-08 21 4.883e-07 60 Genes involved in Deadenylation of mRNA www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_AMINO_ACIDS View Gene Set 7.86e-08 162 5.541e-07 61 Genes involved in Metabolism of amino acids www.broad.mit.e...
Broad REACTOME_REV_MEDIATED_NUCLEAR_EXPORT_OF_HIV1_RNA View Gene Set 1.925e-07 31 1.335e-06 62 Genes involved in Rev-mediated nuclear export of HIV-1 RNA www.broad.mit.e...
Broad REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN View Gene Set 1.977e-07 30 1.349e-06 63 Genes involved in Nuclear import of Rev protein www.broad.mit.e...
Broad REACTOME_G2_M_CHECKPOINTS View Gene Set 2.507e-07 43 1.684e-06 64 Genes involved in G2/M Checkpoints www.broad.mit.e...
Broad REACTOME_VPR_MEDIATED_NUCLEAR_IMPORT_OF_PICS View Gene Set 5.346e-07 31 3.537e-06 65 Genes involved in Vpr-mediated nuclear import of PICs www.broad.mit.e...
Broad REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING View Gene Set 6.14e-07 61 4e-06 66 Genes involved in Clathrin derived vesicle budding www.broad.mit.e...
Broad REACTOME_DNA_STRAND_ELONGATION View Gene Set 7.14e-07 31 4.582e-06 67 Genes involved in DNA strand elongation www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_THE_SLBP_INDEPENDENT_MATURE_MRNA View Gene Set 7.336e-07 32 4.639e-06 68 Genes involved in Transport of the SLBP independent Mature mRNA www.broad.mit.e...
Broad REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY View Gene Set 7.501e-07 29 4.674e-06 69 Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION View Gene Set 7.787e-07 83 4.783e-06 70 Genes involved in RNA Polymerase II Transcription www.broad.mit.e...
Broad REACTOME_MTOR_SIGNALLING View Gene Set 9.047e-07 27 5.479e-06 71 Genes involved in mTOR signalling www.broad.mit.e...
Broad REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS View Gene Set 1.557e-06 29 9.297e-06 72 Genes involved in Transport of Ribonucleoproteins into the Host Nucleus www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_CARBOHYDRATES View Gene Set 2.038e-06 119 1.201e-05 73 Genes involved in Metabolism of carbohydrates www.broad.mit.e...
Broad REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES View Gene Set 4.197e-06 18 2.439e-05 74 Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates www.broad.mit.e...
Broad REACTOME_CITRIC_ACID_CYCLE View Gene Set 5.534e-06 19 3.173e-05 75 Genes involved in Citric acid cycle (TCA cycle) www.broad.mit.e...
Broad REACTOME_MRNA_SPLICING_MINOR_PATHWAY View Gene Set 8.231e-06 38 4.657e-05 76 Genes involved in mRNA Splicing - Minor Pathway www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS View Gene Set 1.008e-05 37 5.631e-05 77 Genes involved in Activation of ATR in response to replication stress www.broad.mit.e...
Broad REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION View Gene Set 1.028e-05 33 5.665e-05 78 Genes involved in E2F mediated regulation of DNA replication www.broad.mit.e...
Broad REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS View Gene Set 1.241e-05 54 6.756e-05 79 Genes involved in Golgi Associated Vesicle Biogenesis www.broad.mit.e...
Broad REACTOME_PYRUVATE_METABOLISM_AND_TCA_CYCLE View Gene Set 1.732e-05 36 9.31e-05 80 Genes involved in Pyruvate metabolism and TCA cycle www.broad.mit.e...
Broad REACTOME_CYCLIN_A1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION View Gene Set 1.919e-05 15 0.0001019 81 Genes involved in Cyclin A1 associated events during G2/M transition www.broad.mit.e...
Broad REACTOME_APOPTOSIS View Gene Set 2.142e-05 129 0.0001123 82 Genes involved in Apoptosis www.broad.mit.e...
Broad REACTOME_E2F_TRANSCRIPTIONAL_TARGETS_AT_G1_S View Gene Set 2.773e-05 22 0.0001437 83 Genes involved in E2F transcriptional targets at G1/S www.broad.mit.e...
Broad REACTOME_G2_M_TRANSITION View Gene Set 3.352e-05 84 0.0001716 84 Genes involved in G2/M Transition www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX View Gene Set 4.764e-05 30 0.000241 85 Genes involved in Activation of the pre-replicative complex www.broad.mit.e...
Broad REACTOME_GLOBAL_GENOMIC_NER View Gene Set 5.229e-05 33 0.0002614 86 Genes involved in Global Genomic NER (GG-NER) www.broad.mit.e...
Broad REACTOME_NUCLEOTIDE_EXCISION_REPAIR View Gene Set 5.42e-05 49 0.0002679 87 Genes involved in Nucleotide Excision Repair www.broad.mit.e...
Broad REACTOME_PURINE_METABOLISM View Gene Set 6.611e-05 30 0.000323 88 Genes involved in Purine metabolism www.broad.mit.e...
Broad REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN View Gene Set 6.779e-05 29 0.0003275 89 Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein www.broad.mit.e...
Broad REACTOME_EXTENSION_OF_TELOMERES View Gene Set 8.006e-05 28 0.0003825 90 Genes involved in Extension of Telomeres www.broad.mit.e...
Broad REACTOME_UNFOLDED_PROTEIN_RESPONSE View Gene Set 9.151e-05 19 0.0004324 91 Genes involved in Unfolded Protein Response www.broad.mit.e...
Broad REACTOME_UNWINDING_OF_DNA View Gene Set 9.619e-05 11 0.0004496 92 Genes involved in Unwinding of DNA www.broad.mit.e...
Broad REACTOME_APCDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B View Gene Set 0.000113 18 0.0005125 93 Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B www.broad.mit.e...
Broad REACTOME_INACTIVATION_OF_APC_VIA_DIRECT_INHIBITION_OF_THE_APCOMPLEX View Gene Set 0.0001114 18 0.0005125 93 Genes involved in Inactivation of APC/C via direct inhibition of the APC/C complex www.broad.mit.e...
Broad REACTOME_MRNA_3_END_PROCESSING View Gene Set 0.0001132 25 0.0005125 93 Genes involved in mRNA 3-end processing www.broad.mit.e...
Broad REACTOME_PHOSPHORYLATION_OF_THE_APC View Gene Set 0.000122 17 0.0005465 96 Genes involved in Phosphorylation of the APC/C www.broad.mit.e...
Broad REACTOME_GLUCOSE_METABOLISM View Gene Set 0.0001355 56 0.0006007 97 Genes involved in Glucose metabolism www.broad.mit.e...
Broad REACTOME_GLUCOSE_TRANSPORT View Gene Set 0.0001396 38 0.0006126 98 Genes involved in Glucose transport www.broad.mit.e...
Broad REACTOME_PEROXISOMAL_LIPID_METABOLISM View Gene Set 0.0001483 20 0.0006442 99 Genes involved in Peroxisomal lipid metabolism www.broad.mit.e...
Broad REACTOME_SIGNALLING_BY_NGF View Gene Set 0.0001709 216 0.000735 100 Genes involved in Signalling by NGF www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION View Gene Set 0.0001837 34 0.0007822 101 Genes involved in RNA Polymerase III Transcription www.broad.mit.e...
Broad REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING View Gene Set 0.0001903 15 0.0007946 102 Genes involved in Formation of ATP by chemiosmotic coupling www.broad.mit.e...
Broad REACTOME_ACTIVATION_OF_CHAPERONES_BY_IRE1_ALPHA View Gene Set 0.0001891 10 0.0007946 102 Genes involved in Activation of Chaperones by IRE1alpha www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME View Gene Set 0.0002058 59 0.0008509 104 Genes involved in Transcription of the HIV genome www.broad.mit.e...
Broad REACTOME_TRKA_SIGNALLING_FROM_THE_PLASMA_MEMBRANE View Gene Set 0.0002833 103 0.00116 105 Genes involved in TRKA signalling from the plasma membrane www.broad.mit.e...
Broad REACTOME_MTORC1_MEDIATED_SIGNALLING View Gene Set 0.0003163 11 0.001283 106 Genes involved in mTORC1-mediated signalling www.broad.mit.e...
Broad REACTOME_TRANSFORMATION_OF_LANOSTEROL_TO_CHOLESTEROL View Gene Set 0.0003256 10 0.001309 107 Genes involved in Transformation of lanosterol to cholesterol www.broad.mit.e...
Broad REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS View Gene Set 0.000403 11 0.001605 108 Genes involved in Purine ribonucleoside monophosphate biosynthesis www.broad.mit.e...
Broad REACTOME_SIGNALING_BY_EGFR View Gene Set 0.0004168 48 0.001644 109 Genes involved in Signaling by EGFR www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_ELONGATION View Gene Set 0.0004608 41 0.001801 110 Genes involved in HIV-1 Transcription Elongation www.broad.mit.e...
Broad REACTOME_G1_PHASE View Gene Set 0.0004748 16 0.001839 111 Genes involved in G1 Phase www.broad.mit.e...
Broad REACTOME_LAGGING_STRAND_SYNTHESIS View Gene Set 0.0005461 20 0.002074 112 Genes involved in Lagging Strand Synthesis www.broad.mit.e...
Broad REACTOME_P38MAPK_EVENTS View Gene Set 0.0005478 13 0.002074 112 Genes involved in p38MAPK events www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_III_AND_MITOCHONDRIAL_TRANSCRIPTION View Gene Set 0.0005498 120 0.002074 112 Genes involved in RNA Polymerase I RNA Polymerase III and Mitochondrial Transcription www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS View Gene Set 0.0005669 29 0.00212 115 Genes involved in Association of TriC/CCT with target proteins during biosynthesis www.broad.mit.e...
Broad REACTOME_TRANSCRIPTION_COUPLED_NER View Gene Set 0.0008375 44 0.003105 116 Genes involved in Transcription-coupled NER (TC-NER) www.broad.mit.e...
Broad REACTOME_FURTHER_PLATELET_RELEASATE View Gene Set 0.0008966 24 0.003295 117 Genes involved in Further platelet releasate www.broad.mit.e...
Broad REACTOME_PI3K_AKT_SIGNALLING View Gene Set 0.0009998 37 0.003643 118 Genes involved in PI3K/AKT signalling www.broad.mit.e...
Broad REACTOME_MICRORNA_BIOGENESIS View Gene Set 0.00103 18 0.003721 119 Genes involved in MicroRNA biogenesis www.broad.mit.e...
Broad REACTOME_SIGNALLING_TO_RAS View Gene Set 0.001104 26 0.003956 120 Genes involved in Signalling to RAS www.broad.mit.e...
Broad REACTOME_TELOMERE_MAINTENANCE View Gene Set 0.001288 77 0.004577 121 Genes involved in Telomere Maintenance www.broad.mit.e...
Broad REACTOME_DOWN_STREAM_SIGNAL_TRANSDUCTION View Gene Set 0.001381 35 0.004868 122 Genes involved in Down-stream signal transduction www.broad.mit.e...
Broad REACTOME_CENTROSOME_MATURATION View Gene Set 0.001402 72 0.0049 123 Genes involved in Centrosome maturation www.broad.mit.e...
Broad REACTOME_SHC_MEDIATED_SIGNALLING View Gene Set 0.001476 12 0.005119 124 Genes involved in SHC-mediated signalling www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_TERMINATION View Gene Set 0.00151 17 0.005193 125 Genes involved in RNA Polymerase III Transcription Termination www.broad.mit.e...
Broad REACTOME_GRB2_EVENTS_IN_EGFR_SIGNALING View Gene Set 0.001551 13 0.005292 126 Genes involved in Grb2 events in EGFR signaling www.broad.mit.e...
Broad REACTOME_IRS_RELATED_EVENTS View Gene Set 0.001594 79 0.005399 127 Genes involved in IRS-related events www.broad.mit.e...
Broad REACTOME_POLYMERASE_SWITCHING View Gene Set 0.001713 14 0.005754 128 Genes involved in Polymerase switching www.broad.mit.e...
Broad REACTOME_ERK_MAPK_TARGETS View Gene Set 0.001958 21 0.006525 129 Genes involved in ERK/MAPK targets www.broad.mit.e...
Broad REACTOME_LYSOSOME_VESICLE_BIOGENESIS View Gene Set 0.002009 24 0.006594 130 Genes involved in Lysosome Vesicle Biogenesis www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS View Gene Set 0.002005 42 0.006594 130 Genes involved in Metabolism of vitamins and cofactors www.broad.mit.e...
Broad REACTOME_DOUBLE_STRAND_BREAK_REPAIR View Gene Set 0.002168 21 0.007064 132 Genes involved in Double-Strand Break Repair www.broad.mit.e...
Broad REACTOME_SHC_RELATED_EVENTS View Gene Set 0.002309 14 0.007467 133 Genes involved in SHC-related events www.broad.mit.e...
Broad REACTOME_DUAL_INCISION_REACTION_IN_GG_NER View Gene Set 0.002346 20 0.007527 134 Genes involved in Dual incision reaction in GG-NER www.broad.mit.e...
Broad REACTOME_SPHINGOLIPID_METABOLISM View Gene Set 0.002381 32 0.007583 135 Genes involved in Sphingolipid metabolism www.broad.mit.e...
Broad REACTOME_REPAIR_SYNTHESIS_OF_PATCH_27_30_BASES_LONG_BY_DNA_POLYMERASE View Gene Set 0.002575 15 0.008083 136 Genes involved in Repair synthesis of patch ~27-30 bases long by DNA polymerase www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE View Gene Set 0.002561 11 0.008083 136 Genes involved in mRNA Decay by 3' to 5' Exoribonuclease www.broad.mit.e...
Broad REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK View Gene Set 0.002602 17 0.008109 138 Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK www.broad.mit.e...
Broad REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION View Gene Set 0.002672 24 0.008265 139 Genes involved in Nuclear Events (kinase and transcription factor activation) www.broad.mit.e...
Broad REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE View Gene Set 0.002873 13 0.008825 140 Genes involved in mRNA Decay by 5' to 3' Exoribonuclease www.broad.mit.e...
Broad REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS View Gene Set 0.003146 228 0.009526 141 Genes involved in Metabolism of lipids and lipoproteins www.broad.mit.e...
Broad REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PREREPLICATIVE_COMPLEX View Gene Set 0.003143 12 0.009526 141 Genes involved in Association of licensing factors with the pre-replicative complex www.broad.mit.e...
Broad REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL View Gene Set 0.00326 14 0.009803 143 Genes involved in AKT phosphorylates targets in the cytosol www.broad.mit.e...
Broad REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING View Gene Set 0.003483 50 0.0104 144 Genes involved in Chaperonin-mediated protein folding www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE View Gene Set 0.00372 14 0.01103 145 Genes involved in Removal of the Flap Intermediate www.broad.mit.e...
Broad REACTOME_TAT_MEDIATED_HIV1_ELONGATION_ARREST_AND_RECOVERY View Gene Set 0.003808 30 0.01122 146 Genes involved in Tat-mediated HIV-1 elongation arrest and recovery www.broad.mit.e...
Broad REACTOME_CONVERSION_FROM_APC_CDC20_TO_APC_CDH1_IN_LATE_ANAPHASE View Gene Set 0.004016 17 0.01172 147 Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION View Gene Set 0.004034 29 0.01172 147 Genes involved in RNA Polymerase III Transcription Initiation www.broad.mit.e...
Broad REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX View Gene Set 0.004309 32 0.01243 149 Genes involved in Formation of the Early Elongation Complex www.broad.mit.e...
Broad REACTOME_COPI_MEDIATED_TRANSPORT View Gene Set 0.004339 10 0.01244 150 Genes involved in COPI Mediated Transport www.broad.mit.e...
Broad REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC:ORIGIN_COMPLEX View Gene Set 0.004797 11 0.01366 151 Genes involved in CDC6 association with the ORC:origin complex www.broad.mit.e...
Broad REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES View Gene Set 0.004891 62 0.01375 152 Genes involved in Loss of Nlp from mitotic centrosomes www.broad.mit.e...
Broad REACTOME_VITAMIN_B5_(PANTOTHENATE)_METABOLISM View Gene Set 0.004894 11 0.01375 152 Genes involved in Vitamin B5 (pantothenate) metabolism www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL View Gene Set 0.00493 17 0.01376 154 Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) www.broad.mit.e...
Broad REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE View Gene Set 0.005373 17 0.01488 155 Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle www.broad.mit.e...
Broad REACTOME_PURINE_SALVAGE_REACTIONS View Gene Set 0.005425 12 0.01488 155 Genes involved in Purine salvage reactions www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER View Gene Set 0.005432 22 0.01488 155 Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND View Gene Set 0.005544 10 0.01509 158 Genes involved in Removal of the Flap Intermediate from the C-strand www.broad.mit.e...
Broad REACTOME_SIGNALLING_TO_ERKS View Gene Set 0.006256 34 0.01692 159 Genes involved in Signalling to ERKs www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION View Gene Set 0.006425 24 0.01727 160 Genes involved in RNA PolymeraseTranscription Initiation www.broad.mit.e...
Broad REACTOME_CHOLESTEROL_BIOSYNTHESIS View Gene Set 0.007146 21 0.01895 161 Genes involved in Cholesterol biosynthesis www.broad.mit.e...
Broad REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION View Gene Set 0.007158 10 0.01895 161 Genes involved in E2F-enabled inhibition of pre-replication complex formation www.broad.mit.e...
Broad REACTOME_HIV1_TRANSCRIPTION_INITIATION View Gene Set 0.007185 39 0.01895 161 Genes involved in HIV-1 Transcription Initiation www.broad.mit.e...
Broad REACTOME_PYRIMIDINE_METABOLISM View Gene Set 0.007403 22 0.01941 164 Genes involved in Pyrimidine metabolism www.broad.mit.e...
Broad REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENES_FAMILY View Gene Set 0.008231 10 0.02145 165 Genes involved in Zinc influx into cells by the SLC39 Genes family www.broad.mit.e...
Broad REACTOME_MRNA_PROCESSING View Gene Set 0.009177 32 0.02377 166 Genes involved in mRNA Processing www.broad.mit.e...
Broad REACTOME_GLUCONEOGENESIS View Gene Set 0.009973 31 0.02568 167 Genes involved in Gluconeogenesis www.broad.mit.e...
Broad REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 View Gene Set 0.01085 14 0.02778 168 Genes involved in Regulation of AMPK activity via LKB1 www.broad.mit.e...
Broad REACTOME_RNA_POL_II_CTD_PHOSPHORYLATION_AND_INTERACTION_WITH_CE View Gene Set 0.01235 26 0.03141 169 Genes involved in RNA Pol II CTD phosphorylation and interaction with CE www.broad.mit.e...
Broad REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES View Gene Set 0.01265 11 0.03199 170 Genes involved in Recruitment of NuMA to mitotic centrosomes www.broad.mit.e...
Broad REACTOME_BASE_EXCISION_REPAIR View Gene Set 0.01295 18 0.03238 171 Genes involved in Base Excision Repair www.broad.mit.e...
Broad REACTOME_SMOOTH_MUSCLE_CONTRACTION View Gene Set 0.01295 24 0.03238 171 Genes involved in Smooth Muscle Contraction www.broad.mit.e...
Broad REACTOME_GLYCOLYSIS View Gene Set 0.01434 22 0.03564 173 Genes involved in Glycolysis www.broad.mit.e...
Broad REACTOME_REMOVAL_OF_DNA_PATCH_CONTAINING_ABASIC_RESIDUE View Gene Set 0.01492 15 0.03687 174 Genes involved in Removal of DNA patch containing abasic residue www.broad.mit.e...
Broad REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION View Gene Set 0.01529 10 0.03758 175 Genes involved in Mitochondrial Fatty Acid Beta-Oxidation www.broad.mit.e...
Broad REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS View Gene Set 0.01627 11 0.03976 176 Genes involved in Apoptotic cleavage of cell adhesion proteins www.broad.mit.e...
Broad REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC View Gene Set 0.01654 28 0.04018 177 Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC www.broad.mit.e...
Broad REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION View Gene Set 0.01824 20 0.04407 178 Genes involved in Mitochondrial tRNA aminoacylation www.broad.mit.e...
Broad REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT View Gene Set 0.01956 23 0.047 179 Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat www.broad.mit.e...
Broad REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE View Gene Set 0.0199 20 0.04754 180 Genes involved in RNA Polymerase I Promoter Escape www.broad.mit.e...
Broad REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR View Gene Set 0.02084 15 0.04945 181 Genes involved in Homologous Recombination Repair www.broad.mit.e...
Broad REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK View Gene Set 0.02093 10 0.04945 181 Genes involved in Regulation of Rheb GTPase activity by AMPK www.broad.mit.e...
Broad REACTOME_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS View Gene Set 0.02106 26 0.04948 183 Genes involved in Synthesis of GPI-anchored proteins www.broad.mit.e...
Broad REACTOME_BETACATENIN_PHOSPHORYLATION_CASCADE View Gene Set 0.02127 13 0.04971 184 Genes involved in Beta-catenin phosphorylation cascade www.broad.mit.e...
Broad REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE View Gene Set 0.02142 13 0.04979 185 Genes involved in Early Phase of HIV Life Cycle www.broad.mit.e...

Gene Set Collection: Broad.c3.MIR

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad GTGCCTT MIR-506 View Gene Set 1.144e-07 605 9.527e-06 1 Targets of MicroRNA GTGCCTT MIR-506 www.broad.mit.e... MIR-506...
Broad CTTGTAT MIR-381 View Gene Set 1.733e-07 167 9.527e-06 1 Targets of MicroRNA CTTGTAT MIR-381 www.broad.mit.e... MIR-381...
Broad TGCCTTA MIR-124A View Gene Set 1.307e-07 471 9.527e-06 1 Targets of MicroRNA TGCCTTA MIR-124A www.broad.mit.e... MIR-124A...
Broad TTTTGAG MIR-373 View Gene Set 5.576e-08 189 9.527e-06 1 Targets of MicroRNA TTTTGAG MIR-373 www.broad.mit.e... MIR-373...
Broad TAATGTG MIR-323 View Gene Set 2.155e-07 135 9.527e-06 1 Targets of MicroRNA TAATGTG MIR-323 www.broad.mit.e... MIR-323...
Broad ATGAAGG MIR-205 View Gene Set 5.07e-07 128 1.867e-05 6 Targets of MicroRNA ATGAAGG MIR-205 www.broad.mit.e... MIR-205...
Broad ACCATTT MIR-522 View Gene Set 8.337e-07 137 2.632e-05 7 Targets of MicroRNA ACCATTT MIR-522 www.broad.mit.e... MIR-522...
Broad ACATTCC MIR-1 MIR-206 View Gene Set 3.772e-06 248 0.0001042 8 Targets of MicroRNA ACATTCC MIR-1 MIR-206 www.broad.mit.e... MIR-1... MIR-206...
Broad ATGTTAA MIR-302C View Gene Set 7.105e-06 206 0.0001745 9 Targets of MicroRNA ATGTTAA MIR-302C www.broad.mit.e... MIR-302C...
Broad GGGACCA MIR-133A MIR-133B View Gene Set 8.821e-06 173 0.0001846 10 Targets of MicroRNA GGGACCA MIR-133A MIR-133B www.broad.mit.e... MIR-133A... MIR-133B...
Broad ACACTAC MIR-142-3P View Gene Set 9.188e-06 110 0.0001846 10 Targets of MicroRNA ACACTAC MIR-142-3P www.broad.mit.e... MIR-142-3P...
Broad CAGCTTT MIR-320 View Gene Set 2.521e-05 220 0.0004643 12 Targets of MicroRNA CAGCTTT MIR-320 www.broad.mit.e... MIR-320...
Broad CAGTGTT MIR-141 MIR-200A View Gene Set 2.895e-05 262 0.0004922 13 Targets of MicroRNA CAGTGTT MIR-141 MIR-200A www.broad.mit.e... MIR-141... MIR-200A...
Broad TGCTGCT MIR-15A MIR-16 MIR-15B MIR-195 MIR-424 MIR-497 View Gene Set 4.061e-05 512 0.000528 14 Targets of MicroRNA TGCTGCT MIR-15A MIR-16 MIR-15B MIR-195 MIR-424 MIR-497 www.broad.mit.e... MIR-15A... MIR-16... MIR-15B... MIR-195... MIR-424... MIR-497...
Broad TGCACTT MIR-519C MIR-519B MIR-519A View Gene Set 3.846e-05 377 0.000528 14 Targets of MicroRNA TGCACTT MIR-519C MIR-519B MIR-519A www.broad.mit.e... MIR-519C... MIR-519B... MIR-519A...
Broad TTGGAGA MIR-515-5P MIR-519E View Gene Set 3.923e-05 120 0.000528 14 Targets of MicroRNA TTGGAGA MIR-515-5P MIR-519E www.broad.mit.e... MIR-515-5P... MIR-519E...
Broad TTGCCAA MIR-182 View Gene Set 4.02e-05 274 0.000528 14 Targets of MicroRNA TTGCCAA MIR-182 www.broad.mit.e... MIR-182...
Broad GACTGTT MIR-212 MIR-132 View Gene Set 4.894e-05 134 0.0006009 18 Targets of MicroRNA GACTGTT MIR-212 MIR-132 www.broad.mit.e... MIR-212... MIR-132...
Broad TTTGCAG MIR-518A-2 View Gene Set 9.928e-05 174 0.001155 19 Targets of MicroRNA TTTGCAG MIR-518A-2 www.broad.mit.e... MIR-518A-2...
Broad AGTCAGC MIR-345 View Gene Set 0.0001577 52 0.00167 20 Targets of MicroRNA AGTCAGC MIR-345 www.broad.mit.e... MIR-345...
Broad TATCTGG MIR-488 View Gene Set 0.0001587 49 0.00167 20 Targets of MicroRNA TATCTGG MIR-488 www.broad.mit.e... MIR-488...
Broad ATATGCA MIR-448 View Gene Set 0.0002131 184 0.002141 22 Targets of MicroRNA ATATGCA MIR-448 www.broad.mit.e... MIR-448...
Broad GAGACTG MIR-452 View Gene Set 0.0002465 78 0.002344 23 Targets of MicroRNA GAGACTG MIR-452 www.broad.mit.e... MIR-452...
Broad TCCAGAG MIR-518C View Gene Set 0.0002545 127 0.002344 23 Targets of MicroRNA TCCAGAG MIR-518C www.broad.mit.e... MIR-518C...
Broad GTACTGT MIR-101 View Gene Set 0.0002724 221 0.002408 25 Targets of MicroRNA GTACTGT MIR-101 www.broad.mit.e... MIR-101...
Broad ACTGCAG MIR-17-3P View Gene Set 0.000294 88 0.002499 26 Targets of MicroRNA ACTGCAG MIR-17-3P www.broad.mit.e... MIR-17-3P...
Broad GTGCAAT MIR-25 MIR-32 MIR-92 MIR-363 MIR-367 View Gene Set 0.0003181 260 0.002604 27 Targets of MicroRNA GTGCAAT MIR-25 MIR-32 MIR-92 MIR-363 MIR-367 www.broad.mit.e... MIR-25... MIR-32... MIR-92... MIR-363... MIR-367...
Broad TGAGATT MIR-216 View Gene Set 0.0003416 90 0.002696 28 Targets of MicroRNA TGAGATT MIR-216 www.broad.mit.e... MIR-216...
Broad TCATCTC MIR-143 View Gene Set 0.0003563 126 0.002715 29 Targets of MicroRNA TCATCTC MIR-143 www.broad.mit.e... MIR-143...
Broad TCTGATA MIR-361 View Gene Set 0.0003902 74 0.002874 30 Targets of MicroRNA TCTGATA MIR-361 www.broad.mit.e... MIR-361...
Broad AAAGGGA MIR-204 MIR-211 View Gene Set 0.0004463 191 0.003077 31 Targets of MicroRNA AAAGGGA MIR-204 MIR-211 www.broad.mit.e... MIR-204... MIR-211...
Broad CTTTGTA MIR-524 View Gene Set 0.0004595 375 0.003077 31 Targets of MicroRNA CTTTGTA MIR-524 www.broad.mit.e... MIR-524...
Broad ACTGCCT MIR-34B View Gene Set 0.0004477 190 0.003077 31 Targets of MicroRNA ACTGCCT MIR-34B www.broad.mit.e... MIR-34B...
Broad TGTGTGA MIR-377 View Gene Set 0.0004896 162 0.003183 34 Targets of MicroRNA TGTGTGA MIR-377 www.broad.mit.e... MIR-377...
Broad TACTTGA MIR-26A MIR-26B View Gene Set 0.0005146 258 0.003249 35 Targets of MicroRNA TACTTGA MIR-26A MIR-26B www.broad.mit.e... MIR-26A... MIR-26B...
Broad ATAACCT MIR-154 View Gene Set 0.0006361 51 0.003905 36 Targets of MicroRNA ATAACCT MIR-154 www.broad.mit.e... MIR-154...
Broad TTGGGAG MIR-150 View Gene Set 0.0006872 65 0.004105 37 Targets of MicroRNA TTGGGAG MIR-150 www.broad.mit.e... MIR-150...
Broad GCACCTT MIR-18A MIR-18B View Gene Set 0.0007216 90 0.004197 38 Targets of MicroRNA GCACCTT MIR-18A MIR-18B www.broad.mit.e... MIR-18A... MIR-18B...
Broad ATCATGA MIR-433 View Gene Set 0.0008131 94 0.004607 39 Targets of MicroRNA ATCATGA MIR-433 www.broad.mit.e... MIR-433...
Broad ACACTGG MIR-199A MIR-199B View Gene Set 0.0008703 134 0.004809 40 Targets of MicroRNA ACACTGG MIR-199A MIR-199B www.broad.mit.e... MIR-199A... MIR-199B...
Broad CAGTATT MIR-200B MIR-200C MIR-429 View Gene Set 0.0008968 386 0.004834 41 Targets of MicroRNA CAGTATT MIR-200B MIR-200C MIR-429 www.broad.mit.e... MIR-200B... MIR-200C... MIR-429...
Broad ACACTCC MIR-122A View Gene Set 0.0009584 67 0.005043 42 Targets of MicroRNA ACACTCC MIR-122A www.broad.mit.e... MIR-122A...
Broad AAGTCCA MIR-422B MIR-422A View Gene Set 0.001226 54 0.006299 43 Targets of MicroRNA AAGTCCA MIR-422B MIR-422A www.broad.mit.e... MIR-422B... MIR-422A...
Broad TCTATGA MIR-376A MIR-376B View Gene Set 0.001699 71 0.008418 44 Targets of MicroRNA TCTATGA MIR-376A MIR-376B www.broad.mit.e... MIR-376A... MIR-376B...
Broad CTGTTAC MIR-194 View Gene Set 0.001714 90 0.008418 44 Targets of MicroRNA CTGTTAC MIR-194 www.broad.mit.e... MIR-194...
Broad GTGCCAT MIR-183 View Gene Set 0.002367 152 0.01137 46 Targets of MicroRNA GTGCCAT MIR-183 www.broad.mit.e... MIR-183...
Broad ATTACAT MIR-380-3P View Gene Set 0.002497 87 0.01174 47 Targets of MicroRNA ATTACAT MIR-380-3P www.broad.mit.e... MIR-380-3P...
Broad CATTTCA MIR-203 View Gene Set 0.002565 235 0.01181 48 Targets of MicroRNA CATTTCA MIR-203 www.broad.mit.e... MIR-203...
Broad CACTGTG MIR-128A MIR-128B View Gene Set 0.002752 276 0.01228 49 Targets of MicroRNA CACTGTG MIR-128A MIR-128B www.broad.mit.e... MIR-128A... MIR-128B...
Broad GGCAGTG MIR-324-3P View Gene Set 0.002818 82 0.01228 49 Targets of MicroRNA GGCAGTG MIR-324-3P www.broad.mit.e... MIR-324-3P...
Broad TTTGTAG MIR-520D View Gene Set 0.002945 279 0.01228 49 Targets of MicroRNA TTTGTAG MIR-520D www.broad.mit.e... MIR-520D...
Broad AACTGGA MIR-145 View Gene Set 0.002925 191 0.01228 49 Targets of MicroRNA AACTGGA MIR-145 www.broad.mit.e... MIR-145...
Broad CACCAGC MIR-138 View Gene Set 0.002849 173 0.01228 49 Targets of MicroRNA CACCAGC MIR-138 www.broad.mit.e... MIR-138...
Broad ACAACTT MIR-382 View Gene Set 0.003604 64 0.01448 54 Targets of MicroRNA ACAACTT MIR-382 www.broad.mit.e... MIR-382...
Broad GTCTTCC MIR-7 View Gene Set 0.003583 132 0.01448 54 Targets of MicroRNA GTCTTCC MIR-7 www.broad.mit.e... MIR-7...
Broad CTCTGGA MIR-520A MIR-525 View Gene Set 0.003726 128 0.0147 56 Targets of MicroRNA CTCTGGA MIR-520A MIR-525 www.broad.mit.e... MIR-520A... MIR-525...
Broad CAGTCAC MIR-134 View Gene Set 0.004364 38 0.01692 57 Targets of MicroRNA CAGTCAC MIR-134 www.broad.mit.e... MIR-134...
Broad TAGGTCA MIR-192 MIR-215 View Gene Set 0.004469 37 0.01703 58 Targets of MicroRNA TAGGTCA MIR-192 MIR-215 www.broad.mit.e... MIR-192... MIR-215...
Broad ATTCTTT MIR-186 View Gene Set 0.004851 232 0.01817 59 Targets of MicroRNA ATTCTTT MIR-186 www.broad.mit.e... MIR-186...
Broad GTTTGTT MIR-495 View Gene Set 0.005372 205 0.01979 60 Targets of MicroRNA GTTTGTT MIR-495 www.broad.mit.e... MIR-495...
Broad TGAATGT MIR-181A MIR-181B MIR-181C MIR-181D View Gene Set 0.006209 418 0.02226 61 Targets of MicroRNA TGAATGT MIR-181A MIR-181B MIR-181C MIR-181D www.broad.mit.e... MIR-181A... MIR-181B... MIR-181C... MIR-181D...
Broad AAAGGAT MIR-501 View Gene Set 0.006244 107 0.02226 61 Targets of MicroRNA AAAGGAT MIR-501 www.broad.mit.e... MIR-501...
Broad ACTTTAT MIR-142-5P View Gene Set 0.006465 250 0.02268 63 Targets of MicroRNA ACTTTAT MIR-142-5P www.broad.mit.e... MIR-142-5P...
Broad CATGTAA MIR-496 View Gene Set 0.006677 150 0.02306 64 Targets of MicroRNA CATGTAA MIR-496 www.broad.mit.e... MIR-496...
Broad AAGCACT MIR-520F View Gene Set 0.007041 198 0.02394 65 Targets of MicroRNA AAGCACT MIR-520F www.broad.mit.e... MIR-520F...
Broad ACTGTAG MIR-139 View Gene Set 0.007353 111 0.02462 66 Targets of MicroRNA ACTGTAG MIR-139 www.broad.mit.e... MIR-139...
Broad TTTGCAC MIR-19A MIR-19B View Gene Set 0.008535 440 0.02774 67 Targets of MicroRNA TTTGCAC MIR-19A MIR-19B www.broad.mit.e... MIR-19A... MIR-19B...
Broad GAGCCAG MIR-149 View Gene Set 0.008466 125 0.02774 67 Targets of MicroRNA GAGCCAG MIR-149 www.broad.mit.e... MIR-149...
Broad ATGCAGT MIR-217 View Gene Set 0.008792 93 0.02816 69 Targets of MicroRNA ATGCAGT MIR-217 www.broad.mit.e... MIR-217...
Broad GTATGAT MIR-154 MIR-487 View Gene Set 0.009098 51 0.02873 70 Targets of MicroRNA GTATGAT MIR-154 MIR-487 www.broad.mit.e... MIR-154... MIR-487...
Broad CAGCAGG MIR-370 View Gene Set 0.01004 128 0.03125 71 Targets of MicroRNA CAGCAGG MIR-370 www.broad.mit.e... MIR-370...
Broad TCCGTCC MIR-184 View Gene Set 0.01021 10 0.03135 72 Targets of MicroRNA TCCGTCC MIR-184 www.broad.mit.e... MIR-184...
Broad TTGCACT MIR-130A MIR-301 MIR-130B View Gene Set 0.01041 335 0.03151 73 Targets of MicroRNA TTGCACT MIR-130A MIR-301 MIR-130B www.broad.mit.e... MIR-130A... MIR-301... MIR-130B...
Broad GTAAACC MIR-299-5P View Gene Set 0.011 44 0.03284 74 Targets of MicroRNA GTAAACC MIR-299-5P www.broad.mit.e... MIR-299-5P...
Broad GCTCTTG MIR-335 View Gene Set 0.01155 70 0.03322 75 Targets of MicroRNA GCTCTTG MIR-335 www.broad.mit.e... MIR-335...
Broad TAGCTTT MIR-9 View Gene Set 0.01131 198 0.03322 75 Targets of MicroRNA TAGCTTT MIR-9 www.broad.mit.e... MIR-9...
Broad TCTGGAC MIR-198 View Gene Set 0.01157 69 0.03322 75 Targets of MicroRNA TCTGGAC MIR-198 www.broad.mit.e... MIR-198...
Broad TCCAGAT MIR-516-5P View Gene Set 0.0118 93 0.03344 78 Targets of MicroRNA TCCAGAT MIR-516-5P www.broad.mit.e... MIR-516-5P...
Broad GCTGAGT MIR-512-5P View Gene Set 0.01249 48 0.03494 79 Targets of MicroRNA GCTGAGT MIR-512-5P www.broad.mit.e... MIR-512-5P...
Broad AGCACTT MIR-93 MIR-302A MIR-302B MIR-302C MIR-302D MIR-372 MIR-373 MIR-520E MIR-520A MIR-526B MIR-520B MIR-520C MIR-520D View Gene Set 0.0132 281 0.03646 80 Targets of MicroRNA AGCACTT MIR-93 MIR-302A MIR-302B MIR-302C MIR-302D MIR-372 MIR-373 MIR-520E MIR-520A MIR-526B MIR-520B MIR-520C MIR-520D www.broad.mit.e... MIR-93... MIR-302A... MIR-302B... MIR-302C... MIR-302D... MIR-372... MIR-373... MIR-520E... MIR-520A... MIR-526B... MIR-520B... MIR-520C... MIR-520D...
Broad AAGGGAT MIR-188 View Gene Set 0.01356 65 0.03701 81 Targets of MicroRNA AAGGGAT MIR-188 www.broad.mit.e... MIR-188...
Broad AGGTGCA MIR-500 View Gene Set 0.01393 79 0.03755 82 Targets of MicroRNA AGGTGCA MIR-500 www.broad.mit.e... MIR-500...
Broad AGGCACT MIR-515-3P View Gene Set 0.01457 74 0.03878 83 Targets of MicroRNA AGGCACT MIR-515-3P www.broad.mit.e... MIR-515-3P...
Broad GCACTTT MIR-17-5P MIR-20A MIR-106A MIR-106B MIR-20B MIR-519D View Gene Set 0.01505 506 0.03958 84 Targets of MicroRNA GCACTTT MIR-17-5P MIR-20A MIR-106A MIR-106B MIR-20B MIR-519D www.broad.mit.e... MIR-17-5P... MIR-20A... MIR-106A... MIR-106B... MIR-20B... MIR-519D...
Broad CTCCAAG MIR-432 View Gene Set 0.01552 65 0.04036 85 Targets of MicroRNA CTCCAAG MIR-432 www.broad.mit.e... MIR-432...
Broad CTCAGGG MIR-125B MIR-125A View Gene Set 0.01591 277 0.04059 86 Targets of MicroRNA CTCAGGG MIR-125B MIR-125A www.broad.mit.e... MIR-125B... MIR-125A...
Broad ATGTACA MIR-493 View Gene Set 0.01598 261 0.04059 86 Targets of MicroRNA ATGTACA MIR-493 www.broad.mit.e... MIR-493...
Broad CCAGGTT MIR-490 View Gene Set 0.01853 52 0.04602 88 Targets of MicroRNA CCAGGTT MIR-490 www.broad.mit.e... MIR-490...
Broad GCATTTG MIR-105 View Gene Set 0.01853 143 0.04602 88 Targets of MicroRNA GCATTTG MIR-105 www.broad.mit.e... MIR-105...
Broad ATACTGT MIR-144 View Gene Set 0.0203 173 0.04985 90 Targets of MicroRNA ATACTGT MIR-144 www.broad.mit.e... MIR-144...

Gene Set Collection: Broad.c3.TFT

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad SCGGAAGY_V$ELK1_02 View Gene Set 5.178e-40 784 3.184e-37 1 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SCGGAAGY which matches annotation for ELK1: ELK1 member of ETS oncogene family www.broad.mit.e...
Broad RCGCANGCGY_V$NRF1_Q6 View Gene Set 1.944e-32 580 5.978e-30 2 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif RCGCANGCGY which matches annotation for NRF1: nuclear respiratory factor 1 www.broad.mit.e...
Broad GCCATNTTG_V$YY1_Q6 View Gene Set 3.66e-25 289 7.502e-23 3 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCATNTTG which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad GGGCGGR_V$SP1_Q6 View Gene Set 1.024e-22 2120 1.574e-20 4 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GGGCGGR which matches annotation for SP1: Sp1 transcription factor www.broad.mit.e...
Broad CACGTG_V$MYC_Q2 View Gene Set 1.308e-19 734 1.608e-17 5 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CACGTG which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian) www.broad.mit.e...
Broad V$NFMUE1_Q6 View Gene Set 5.455e-18 175 5.591e-16 6 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CGGCCATCT. Motif does not match any known transcription factor www.broad.mit.e...
Broad MGGAAGTG_V$GABP_B View Gene Set 3.899e-17 512 3.425e-15 7 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif MGGAAGTG which matches annotation for GABPA: GA binding protein transcription factor alpha subunit 60kDa<br> GABPB2: GA binding protein transcription factor beta subunit 2 www.broad.mit.e...
Broad V$YY1_Q6 View Gene Set 6.546e-17 166 5.033e-15 8 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCATNTTN which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad V$GABP_B View Gene Set 1.398e-14 162 9.555e-13 9 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif VCCGGAAGNGCR which matches annotation for GABPA: GA binding protein transcription factor alpha subunit 60kDa<br> GABPB2: GA binding protein transcription factor beta subunit 2 www.broad.mit.e...
Broad V$ELK1_02 View Gene Set 1.003e-12 170 6.169e-11 10 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNCCGGAARTNN which matches annotation for ELK1: ELK1 member of ETS oncogene family www.broad.mit.e...
Broad GGCNKCCATNK_UNKNOWN View Gene Set 2.167e-12 84 1.162e-10 11 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNKCCATNK. Motif does not match any known transcription factor www.broad.mit.e...
Broad TGCGCANK_UNKNOWN View Gene Set 2.268e-12 361 1.162e-10 11 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TGCGCANK. Motif does not match any known transcription factor www.broad.mit.e...
Broad TMTCGCGANR_UNKNOWN View Gene Set 4.946e-12 100 2.34e-10 13 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TMTCGCGANR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$YY1_02 View Gene Set 1.709e-11 168 7.509e-10 14 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNCGGCCATCTTGNCTSNW which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad V$NRF2_01 View Gene Set 7.105e-11 166 2.736e-09 15 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif ACCGGAAGNG which matches annotation for GABPB1: GA binding protein transcription factor beta subunit 1. www.broad.mit.e...
Broad ACTAYRNNNCCCR_UNKNOWN View Gene Set 7.119e-11 293 2.736e-09 15 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ACTAYRNNNCCCR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q6_01 View Gene Set 2.25e-10 177 8.141e-09 17 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTTTCGCGCS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad GGCNNMSMYNTTG_UNKNOWN View Gene Set 3.741e-10 56 1.278e-08 18 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNNMSMYNTTG. Motif does not match any known transcription factor www.broad.mit.e...
Broad SGCGSSAAA_V$E2F1DP2_01 View Gene Set 8.251e-10 122 2.671e-08 19 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SGCGSSAAA which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad V$E2F_03 View Gene Set 1.116e-09 171 3.432e-08 20 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGCGMNR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$ARNT_02 View Gene Set 1.28e-09 179 3.749e-08 21 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNRTCACGTGAYNNNNN which matches annotation for ARNT: aryl hydrocarbon receptor nuclear translocator www.broad.mit.e...
Broad KCCGNSWTTT_UNKNOWN View Gene Set 3.075e-09 76 8.595e-08 22 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif KCCGNSWTTT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$SREBP1_01 View Gene Set 4.241e-09 133 1.134e-07 23 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NATCACGTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 www.broad.mit.e...
Broad TCCCRNNRTGC_UNKNOWN View Gene Set 6.524e-09 130 1.672e-07 24 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TCCCRNNRTGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q6 View Gene Set 8.634e-09 167 2.124e-07 25 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGS which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$MYCMAX_01 View Gene Set 9.061e-09 189 2.143e-07 26 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNACCACGTGGTNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad V$E2F1_Q4_01 View Gene Set 1.029e-08 167 2.345e-07 27 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad GATTGGY_V$NFY_Q6_01 View Gene Set 1.195e-08 830 2.624e-07 28 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GATTGGY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q6 View Gene Set 1.319e-08 165 2.798e-07 29 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q3_01 View Gene Set 1.664e-08 171 3.411e-07 30 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F_Q4 View Gene Set 1.791e-08 166 3.554e-07 31 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGS. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$CETS1P54_01 View Gene Set 2.953e-08 183 5.675e-07 32 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCMGGAWGYN which matches annotation for ETS1: v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) www.broad.mit.e...
Broad V$USF_01 View Gene Set 3.755e-08 186 6.997e-07 33 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNRYCACGTGRYNN. Motif does not match any known transcription factor www.broad.mit.e...
Broad GTGACGY_V$E4F1_Q6 View Gene Set 8.532e-08 462 1.499e-06 34 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GTGACGY which matches annotation for E4F1: E4F transcription factor 1 www.broad.mit.e...
Broad TCANNTGAY_V$SREBP1_01 View Gene Set 8.289e-08 355 1.499e-06 34 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TCANNTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 www.broad.mit.e...
Broad V$NRF1_Q6 View Gene Set 1.39e-07 151 2.374e-06 36 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CGCATGCGCR which matches annotation for NRF1: nuclear respiratory factor 1 www.broad.mit.e...
Broad V$E2F_Q3 View Gene Set 2.412e-07 162 4.009e-06 37 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTCGCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad TAANNYSGCG_UNKNOWN View Gene Set 2.949e-07 60 4.773e-06 38 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TAANNYSGCG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q6_01 View Gene Set 3.19e-07 167 5.031e-06 39 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKCGCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad ACAWNRNSRCGG_UNKNOWN View Gene Set 3.788e-07 50 5.824e-06 40 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ACAWNRNSRCGG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_02 View Gene Set 6.143e-07 169 9.214e-06 41 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTTSGCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF_Q6_01 View Gene Set 6.39e-07 168 9.357e-06 42 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NRCCACGTGASN. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F_Q4_01 View Gene Set 8.576e-07 171 1.227e-05 43 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$MAX_01 View Gene Set 1.017e-06 194 1.422e-05 44 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNANCACGTGNTNN which matches annotation for MAX: MYC associated factor X www.broad.mit.e...
Broad V$E2F1DP1_01 View Gene Set 1.21e-06 169 1.583e-05 45 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad V$E2F1DP2_01 View Gene Set 1.21e-06 169 1.583e-05 45 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSSCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F4DP2_01 View Gene Set 1.21e-06 169 1.583e-05 45 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) www.broad.mit.e...
Broad V$E2F1DP1RB_01 View Gene Set 1.33e-06 168 1.704e-05 48 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F1: E2F transcription factor 1<br> TFDP1: transcription factor Dp-1<br> RB1: retinoblastoma 1 (including osteosarcoma) www.broad.mit.e...
Broad V$USF_C View Gene Set 1.724e-06 211 2.164e-05 49 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NCACGTGN. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F1_Q3 View Gene Set 1.825e-06 176 2.245e-05 50 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NKTSSCGC which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad V$E2F1_Q4 View Gene Set 2.296e-06 178 2.747e-05 51 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTTSGCGG which matches annotation for E2F1: E2F transcription factor 1 www.broad.mit.e...
Broad GATGKMRGCG_UNKNOWN View Gene Set 2.323e-06 47 2.747e-05 51 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GATGKMRGCG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF_02 View Gene Set 2.916e-06 197 3.321e-05 53 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNRNCACGTGNYNN. Motif does not match any known transcription factor www.broad.mit.e...
Broad GCGNNANTTCC_UNKNOWN View Gene Set 2.863e-06 85 3.321e-05 53 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GCGNNANTTCC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$TEL2_Q6 View Gene Set 4.157e-06 158 4.648e-05 55 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif YTACTTCCTG which matches annotation for ETV7: ets variant gene 7 (TEL2 oncogene) www.broad.mit.e...
Broad V$USF_Q6 View Gene Set 4.698e-06 178 5.159e-05 56 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GYCACGTGNC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$E2F4DP1_01 View Gene Set 4.883e-06 174 5.261e-05 57 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TTTSGCGC which matches annotation for E2F4: E2F transcription factor 4 p107/p130-binding<br> TFDP1: transcription factor Dp-1 www.broad.mit.e...
Broad YGCGYRCGC_UNKNOWN View Gene Set 4.962e-06 207 5.261e-05 57 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif YGCGYRCGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$CMYB_01 View Gene Set 8.558e-06 179 8.772e-05 59 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NCNRNNGRCNGTTGGKGG which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) www.broad.mit.e...
Broad GCGSCMNTTT_UNKNOWN View Gene Set 8.443e-06 49 8.772e-05 59 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GCGSCMNTTT. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$STAT1_02 View Gene Set 1.713e-05 179 0.0001727 61 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CANTTCCS which matches annotation for STAT1: signal transducer and activator of transcription 1 91kDa www.broad.mit.e...
Broad V$ARNT_01 View Gene Set 1.771e-05 196 0.0001757 62 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NDDNNCACGTGNNNNN which matches annotation for ARNT: aryl hydrocarbon receptor nuclear translocator www.broad.mit.e...
Broad RRCCGTTA_UNKNOWN View Gene Set 1.903e-05 53 0.0001857 63 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif RRCCGTTA. Motif does not match any known transcription factor www.broad.mit.e...
Broad GGAANCGGAANY_UNKNOWN View Gene Set 2.747e-05 79 0.000264 64 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGAANCGGAANY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$NMYC_01 View Gene Set 3.02e-05 201 0.0002857 65 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNCCACGTGNNN which matches annotation for MYCN: v-myc myelocytomatosis viral related oncogene neuroblastoma derived (avian) www.broad.mit.e...
Broad GGCNRNWCTTYS_UNKNOWN View Gene Set 3.845e-05 52 0.0003583 66 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGCNRNWCTTYS. Motif does not match any known transcription factor www.broad.mit.e...
Broad CCGNMNNTNACG_UNKNOWN View Gene Set 5.416e-05 56 0.0004971 67 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CCGNMNNTNACG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$HIF1_Q3 View Gene Set 6.299e-05 161 0.0005697 68 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GNNKACGTGCGGNN which matches annotation for HIF1A: hypoxia-inducible factor 1 alpha subunit (basic helix-loop-helix transcription factor) www.broad.mit.e...
Broad AAGWWRNYGGC_UNKNOWN View Gene Set 8.614e-05 85 0.0007678 69 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif AAGWWRNYGGC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$USF2_Q6 View Gene Set 9.334e-05 182 0.0008201 70 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CASGYG. Motif does not match any known transcription factor www.broad.mit.e...
Broad TTCNRGNNNNTTC_V$HSF_Q6 View Gene Set 9.598e-05 111 0.0008313 71 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTCNRGNNNNTTC. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$CREB_02 View Gene Set 9.998e-05 185 0.000854 72 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNGNTGACGTNN which matches annotation for CREB1: cAMP responsive element binding protein 1 www.broad.mit.e...
Broad CRGAARNNNNCGA_UNKNOWN View Gene Set 0.00012 34 0.001011 73 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CRGAARNNNNCGA. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$MYCMAX_03 View Gene Set 0.0001274 187 0.001059 74 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNNNCACGTGNNNNNNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad V$YY1_01 View Gene Set 0.0002278 190 0.001868 75 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNCCATNTWNNNWN which matches annotation for YY1: YY1 transcription factor www.broad.mit.e...
Broad KTGGYRSGAA_UNKNOWN View Gene Set 0.0003041 53 0.002461 76 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif KTGGYRSGAA. Motif does not match any known transcription factor www.broad.mit.e...
Broad GKCGCNNNNNNNTGAYG_UNKNOWN View Gene Set 0.0004081 41 0.00326 77 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GKCGCNNNNNNNTGAYG. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$NFY_Q6_01 View Gene Set 0.000448 185 0.003514 78 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NNNNRRCCAATSR. Motif does not match any known transcription factor www.broad.mit.e...
Broad TGACCTY_V$ERR1_Q2 View Gene Set 0.0004514 772 0.003514 78 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TGACCTY which matches annotation for ESRRA: estrogen-related receptor alpha www.broad.mit.e...
Broad V$AHR_Q5 View Gene Set 0.0005865 153 0.004509 80 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NTNGCGTGNNN which matches annotation for AHR: aryl hydrocarbon receptor www.broad.mit.e...
Broad ATCMNTCCGY_UNKNOWN View Gene Set 0.0006883 36 0.005226 81 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ATCMNTCCGY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$MYCMAX_02 View Gene Set 0.0007303 201 0.005477 82 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NANCACGTGNNW which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad TTCYRGAA_UNKNOWN View Gene Set 0.0009091 221 0.006736 83 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TTCYRGAA. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$MYCMAX_B View Gene Set 0.001111 193 0.008135 84 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GCCAYGYGSN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)<br> MAX: MYC associated factor X www.broad.mit.e...
Broad V$E2F_01 View Gene Set 0.001298 55 0.009391 85 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif TWSGCGCGAAAAYKR. Motif does not match any known transcription factor www.broad.mit.e...
Broad ATGGYGGA_UNKNOWN View Gene Set 0.001519 68 0.01086 86 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif ATGGYGGA. Motif does not match any known transcription factor www.broad.mit.e...
Broad CGTSACG_V$PAX3_B View Gene Set 0.001711 99 0.01209 87 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CGTSACG which matches annotation for PAX3: paired box gene 3 (Waardenburg syndrome 1) www.broad.mit.e...
Broad V$MYC_Q2 View Gene Set 0.001881 135 0.01314 88 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CACGTGS which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian) www.broad.mit.e...
Broad V$E4F1_Q6 View Gene Set 0.00238 203 0.01645 89 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif SYTACGTCAC which matches annotation for E4F1: E4F transcription factor 1 www.broad.mit.e...
Broad CTTTGT_V$LEF1_Q2 View Gene Set 0.002794 1458 0.01909 90 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CTTTGT which matches annotation for LEF1: lymphoid enhancer-binding factor 1 www.broad.mit.e...
Broad CCCNNNNNNAAGWT_UNKNOWN View Gene Set 0.002974 74 0.0201 91 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CCCNNNNNNAAGWT. Motif does not match any known transcription factor www.broad.mit.e...
Broad GGGNRMNNYCAT_UNKNOWN View Gene Set 0.004407 61 0.0292 92 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGGNRMNNYCAT. Motif does not match any known transcription factor www.broad.mit.e...
Broad YGCANTGCR_UNKNOWN View Gene Set 0.004415 93 0.0292 92 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif YGCANTGCR. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$ATF4_Q2 View Gene Set 0.004475 188 0.02928 94 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif CVTGACGYMABG which matches annotation for ATF4: activating transcription factor 4 (tax-responsive enhancer element B67) www.broad.mit.e...
Broad V$PR_01 View Gene Set 0.004814 109 0.03116 95 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNNNNGGNACRNNNTGTTCTNNNNNN which matches annotation for PGR: progesterone receptor www.broad.mit.e...
Broad V$NFY_C View Gene Set 0.005334 179 0.03417 96 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif NCTGATTGGYTASY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$STAT1_01 View Gene Set 0.005571 49 0.03496 97 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif NNNSANTTCCGGGAANTGNSN which matches annotation for STAT1: signal transducer and activator of transcription 1 91kDa www.broad.mit.e...
Broad TGACCTTG_V$SF1_Q6 View Gene Set 0.005534 188 0.03496 97 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif TGACCTTG which matches annotation for SF1: splicing factor 1 www.broad.mit.e...
Broad GGAMTNNNNNTCCY_UNKNOWN View Gene Set 0.007082 85 0.044 99 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif GGAMTNNNNNTCCY. Motif does not match any known transcription factor www.broad.mit.e...
Broad V$SP1_01 View Gene Set 0.007785 181 0.04788 100 Genes with promoter regions [-2kb 2kb] around transcription start site containing the motif GGGGCGGGGT which matches annotation for SP1: Sp1 transcription factor www.broad.mit.e...
Broad CCAWNWWNNNGGC_UNKNOWN View Gene Set 0.008084 56 0.04922 101 Genes with promoter regions [-2kb 2kb] around transcription start site containing motif CCAWNWWNNNGGC. Motif does not match any known transcription factor www.broad.mit.e...

Gene Set Collection: Broad.c4.CGN

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad MORF_RAD23A View Gene Set 1.961e-84 316 8.375e-82 1 Neighborhood of RAD23A www.broad.mit.e...
Broad MORF_BUB3 View Gene Set 1.949e-76 256 4.161e-74 2 Neighborhood of BUB3 www.broad.mit.e...
Broad MORF_GNB1 View Gene Set 3.724e-76 276 5.301e-74 3 Neighborhood of GNB1 www.broad.mit.e...
Broad MORF_RAN View Gene Set 1.121e-74 242 1.197e-72 4 Neighborhood of RAN www.broad.mit.e...
Broad MORF_UBE2I View Gene Set 2.804e-71 208 2.394e-69 5 Neighborhood of UBE2I www.broad.mit.e...
Broad MORF_DEK View Gene Set 2.718e-69 229 1.934e-67 6 Neighborhood of DEK www.broad.mit.e...
Broad MORF_HDAC2 View Gene Set 7.245e-66 256 4.419e-64 7 Neighborhood of HDAC2 www.broad.mit.e...
Broad MORF_SOD1 View Gene Set 5.192e-65 247 2.474e-63 8 Neighborhood of SOD1 www.broad.mit.e...
Broad MORF_CSNK2B View Gene Set 5.215e-65 256 2.474e-63 8 Neighborhood of CSNK2B www.broad.mit.e...
Broad MORF_HDAC1 View Gene Set 5.06e-64 222 2.161e-62 10 Neighborhood of HDAC1 www.broad.mit.e...
Broad MORF_EIF3S2 View Gene Set 2.56e-63 220 9.939e-62 11 Neighborhood of EIF3S2 www.broad.mit.e...
Broad MORF_ACP1 View Gene Set 1.916e-59 178 6.817e-58 12 Neighborhood of ACP1 www.broad.mit.e...
Broad MORF_ANP32B View Gene Set 2.965e-59 174 9.739e-58 13 Neighborhood of ANP32B www.broad.mit.e...
Broad MORF_XRCC5 View Gene Set 6.781e-58 210 2.068e-56 14 Neighborhood of XRCC5 www.broad.mit.e...
Broad MORF_NPM1 View Gene Set 1.103e-57 152 3.14e-56 15 Neighborhood of NPM1 www.broad.mit.e...
Broad MORF_NME2 View Gene Set 3.34e-52 145 8.912e-51 16 Neighborhood of NME2 www.broad.mit.e...
Broad MORF_DAP3 View Gene Set 4.941e-52 175 1.241e-50 17 Neighborhood of DAP3 www.broad.mit.e...
Broad MORF_AP2M1 View Gene Set 3.039e-51 197 7.21e-50 18 Neighborhood of AP2M1 www.broad.mit.e...
Broad MORF_ACTG1 View Gene Set 1.118e-50 134 2.513e-49 19 Neighborhood of ACTG1 www.broad.mit.e...
Broad MORF_PRKDC View Gene Set 3.866e-49 173 8.254e-48 20 Neighborhood of PRKDC www.broad.mit.e...
Broad MORF_G22P1 View Gene Set 2.901e-48 145 5.898e-47 21 Neighborhood of G22P1 www.broad.mit.e...
Broad MORF_AATF View Gene Set 9.457e-48 179 1.835e-46 22 Neighborhood of AATF www.broad.mit.e...
Broad MORF_CTBP1 View Gene Set 2.009e-47 149 3.73e-46 23 Neighborhood of CTBP1 www.broad.mit.e...
Broad MORF_SKP1A View Gene Set 2.69e-47 175 4.786e-46 24 Neighborhood of SKP1A www.broad.mit.e...
Broad MORF_PRKAG1 View Gene Set 7.006e-47 202 1.197e-45 25 Neighborhood of PRKAG1 www.broad.mit.e...
Broad MORF_HAT1 View Gene Set 1.976e-46 155 3.245e-45 26 Neighborhood of HAT1 www.broad.mit.e...
Broad MORF_PPP1CC View Gene Set 2.448e-46 150 3.872e-45 27 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_RAD21 View Gene Set 9.345e-46 157 1.425e-44 28 Neighborhood of RAD21 www.broad.mit.e...
Broad MORF_RAC1 View Gene Set 1.167e-43 196 1.718e-42 29 Neighborhood of RAC1 www.broad.mit.e...
Broad MORF_EIF4A2 View Gene Set 1.012e-42 120 1.441e-41 30 Neighborhood of EIF4A2 www.broad.mit.e...
Broad MORF_FBL View Gene Set 1.002e-41 121 1.38e-40 31 Neighborhood of FBL www.broad.mit.e...
Broad MORF_EI24 View Gene Set 2.657e-41 136 3.546e-40 32 Neighborhood of EI24 www.broad.mit.e...
Broad MORF_PPP1CA View Gene Set 1.855e-40 145 2.4e-39 33 Neighborhood of PPP1CA www.broad.mit.e...
Broad MORF_PRKAR1A View Gene Set 3.5e-40 133 4.395e-39 34 Neighborhood of PRKAR1A www.broad.mit.e...
Broad GNF2_FBL View Gene Set 6.543e-40 119 7.982e-39 35 Neighborhood of FBL www.broad.mit.e...
Broad MORF_DDB1 View Gene Set 4.131e-39 220 4.9e-38 36 Neighborhood of DDB1 www.broad.mit.e...
Broad MORF_EIF3S6 View Gene Set 1.176e-38 108 1.357e-37 37 Neighborhood of EIF3S6 www.broad.mit.e...
Broad GCM_APEX1 View Gene Set 2.049e-38 102 2.302e-37 38 Neighborhood of APEX1 www.broad.mit.e...
Broad MORF_PSMC1 View Gene Set 3.518e-38 162 3.852e-37 39 Neighborhood of PSMC1 www.broad.mit.e...
Broad MORF_RFC4 View Gene Set 1.353e-37 137 1.444e-36 40 Neighborhood of RFC4 www.broad.mit.e...
Broad MORF_RAD23B View Gene Set 2.107e-37 159 2.195e-36 41 Neighborhood of RAD23B www.broad.mit.e...
Broad GNF2_EIF3S6 View Gene Set 3.149e-37 109 3.201e-36 42 Neighborhood of EIF3S6 www.broad.mit.e...
Broad GCM_ACTG1 View Gene Set 6.233e-36 113 6.189e-35 43 Neighborhood of ACTG1 www.broad.mit.e...
Broad MORF_TPT1 View Gene Set 2.823e-35 100 2.74e-34 44 Neighborhood of TPT1 www.broad.mit.e...
Broad MORF_AP3D1 View Gene Set 5.346e-35 119 5.073e-34 45 Neighborhood of AP3D1 www.broad.mit.e...
Broad MORF_ERH View Gene Set 2.28e-34 103 2.116e-33 46 Neighborhood of ERH www.broad.mit.e...
Broad GCM_NPM1 View Gene Set 5.013e-34 108 4.555e-33 47 Neighborhood of NPM1 www.broad.mit.e...
Broad MORF_RPA2 View Gene Set 2.506e-33 170 2.23e-32 48 Neighborhood of RPA2 www.broad.mit.e...
Broad MORF_RAB1A View Gene Set 8.854e-33 179 7.715e-32 49 Neighborhood of RAB1A www.broad.mit.e...
Broad MORF_DNMT1 View Gene Set 1.664e-32 105 1.421e-31 50 Neighborhood of DNMT1 www.broad.mit.e...
Broad GCM_CSNK2B View Gene Set 1.165e-31 88 9.758e-31 51 Neighborhood of CSNK2B www.broad.mit.e...
Broad MORF_CCNI View Gene Set 2.703e-31 76 2.22e-30 52 Neighborhood of CCNI www.broad.mit.e...
Broad GNF2_DAP3 View Gene Set 4.011e-31 98 3.232e-30 53 Neighborhood of DAP3 www.broad.mit.e...
Broad MORF_PAPSS1 View Gene Set 2.772e-30 98 2.192e-29 54 Neighborhood of PAPSS1 www.broad.mit.e...
Broad MORF_PPP2CA View Gene Set 1.811e-29 110 1.406e-28 55 Neighborhood of PPP2CA www.broad.mit.e...
Broad GNF2_PA2G4 View Gene Set 2.901e-29 73 2.212e-28 56 Neighborhood of PA2G4 www.broad.mit.e...
Broad MORF_PCNA View Gene Set 2.382e-28 71 1.784e-27 57 Neighborhood of PCNA www.broad.mit.e...
Broad MORF_RRM1 View Gene Set 5.022e-28 90 3.697e-27 58 Neighborhood of RRM1 www.broad.mit.e...
Broad MORF_MAP2K2 View Gene Set 1.67e-27 123 1.209e-26 59 Neighborhood of MAP2K2 www.broad.mit.e...
Broad GNF2_RAN View Gene Set 1.797e-27 78 1.279e-26 60 Neighborhood of RAN www.broad.mit.e...
Broad MORF_CDC10 View Gene Set 1.921e-27 120 1.345e-26 61 Neighborhood of CDC10 www.broad.mit.e...
Broad GCM_PSME1 View Gene Set 8.096e-27 76 5.576e-26 62 Neighborhood of PSME1 www.broad.mit.e...
Broad GCM_TPT1 View Gene Set 2.54e-25 69 1.721e-24 63 Neighborhood of TPT1 www.broad.mit.e...
Broad GNF2_APEX1 View Gene Set 4.381e-25 72 2.923e-24 64 Neighborhood of APEX1 www.broad.mit.e...
Broad GNF2_RRM1 View Gene Set 1.213e-24 82 7.97e-24 65 Neighborhood of RRM1 www.broad.mit.e...
Broad MORF_RAD54L View Gene Set 4.372e-24 94 2.828e-23 66 Neighborhood of RAD54L www.broad.mit.e...
Broad MORF_SP3 View Gene Set 4.854e-24 69 3.056e-23 67 Neighborhood of SP3 www.broad.mit.e...
Broad GCM_CBFB View Gene Set 4.867e-24 59 3.056e-23 67 Neighborhood of CBFB www.broad.mit.e...
Broad MORF_UBE2N View Gene Set 1.413e-22 79 8.747e-22 69 Neighborhood of UBE2N www.broad.mit.e...
Broad MORF_JUND View Gene Set 1.847e-22 63 1.127e-21 70 Neighborhood of JUND www.broad.mit.e...
Broad MORF_MTA1 View Gene Set 1.917e-22 95 1.153e-21 71 Neighborhood of MTA1 www.broad.mit.e...
Broad MORF_PSMC2 View Gene Set 2.372e-22 100 1.407e-21 72 Neighborhood of PSMC2 www.broad.mit.e...
Broad GNF2_ST13 View Gene Set 2.472e-22 56 1.446e-21 73 Neighborhood of ST13 www.broad.mit.e...
Broad MORF_PTPN11 View Gene Set 1.484e-21 93 8.565e-21 74 Neighborhood of PTPN11 www.broad.mit.e...
Broad MORF_RAF1 View Gene Set 1.573e-21 94 8.953e-21 75 Neighborhood of RAF1 www.broad.mit.e...
Broad GNF2_NPM1 View Gene Set 2.407e-21 57 1.352e-20 76 Neighborhood of NPM1 www.broad.mit.e...
Broad MORF_UNG View Gene Set 7.455e-21 65 4.134e-20 77 Neighborhood of UNG www.broad.mit.e...
Broad MORF_PRDX3 View Gene Set 1.773e-20 79 9.704e-20 78 Neighborhood of PRDX3 www.broad.mit.e...
Broad MORF_RAB6A View Gene Set 5.276e-20 63 2.852e-19 79 Neighborhood of RAB6A www.broad.mit.e...
Broad GNF2_SMC4L1 View Gene Set 7.136e-20 75 3.809e-19 80 Neighborhood of SMC4L1 www.broad.mit.e...
Broad MORF_SART1 View Gene Set 2.037e-19 55 1.074e-18 81 Neighborhood of SART1 www.broad.mit.e...
Broad MORF_ATOX1 View Gene Set 2.126e-19 72 1.107e-18 82 Neighborhood of ATOX1 www.broad.mit.e...
Broad MORF_ESPL1 View Gene Set 4.779e-19 58 2.459e-18 83 Neighborhood of ESPL1 www.broad.mit.e...
Broad MORF_PHB View Gene Set 7.265e-19 112 3.693e-18 84 Neighborhood of PHB www.broad.mit.e...
Broad MORF_FEN1 View Gene Set 9.517e-19 58 4.781e-18 85 Neighborhood of FEN1 www.broad.mit.e...
Broad GCM_PPP1CC View Gene Set 1.381e-18 47 6.855e-18 86 Neighborhood of PPP1CC www.broad.mit.e...
Broad MORF_CUL1 View Gene Set 2.01e-18 62 9.867e-18 87 Neighborhood of CUL1 www.broad.mit.e...
Broad MORF_MBD4 View Gene Set 2.386e-18 76 1.158e-17 88 Neighborhood of MBD4 www.broad.mit.e...
Broad MORF_TERF2IP View Gene Set 2.545e-18 99 1.221e-17 89 Neighborhood of TERF2IP www.broad.mit.e...
Broad GNF2_CDC20 View Gene Set 3.999e-18 52 1.897e-17 90 Neighborhood of CDC20 www.broad.mit.e...
Broad MORF_CDC16 View Gene Set 4.173e-18 67 1.937e-17 91 Neighborhood of CDC16 www.broad.mit.e...
Broad MORF_CDK2 View Gene Set 4.163e-18 63 1.937e-17 91 Neighborhood of CDK2 www.broad.mit.e...
Broad MORF_SMC1L1 View Gene Set 5.635e-18 47 2.587e-17 93 Neighborhood of SMC1L1 www.broad.mit.e...
Broad GNF2_HAT1 View Gene Set 1.184e-17 45 5.376e-17 94 Neighborhood of HAT1 www.broad.mit.e...
Broad GNF2_MCM5 View Gene Set 1.298e-17 51 5.836e-17 95 Neighborhood of MCM5 www.broad.mit.e...
Broad GNF2_CCNA2 View Gene Set 2.237e-17 62 9.95e-17 96 Neighborhood of CCNA2 www.broad.mit.e...
Broad GCM_NF2 View Gene Set 2.323e-17 235 1.012e-16 97 Neighborhood of NF2 www.broad.mit.e...
Broad GNF2_RFC4 View Gene Set 2.32e-17 57 1.012e-16 97 Neighborhood of RFC4 www.broad.mit.e...
Broad MORF_SNRP70 View Gene Set 2.464e-17 50 1.063e-16 99 Neighborhood of SNRP70 www.broad.mit.e...
Broad MORF_BUB1 View Gene Set 3.837e-17 49 1.638e-16 100 Neighborhood of BUB1 www.broad.mit.e...
Broad GCM_DDX5 View Gene Set 4.257e-17 52 1.8e-16 101 Neighborhood of DDX5 www.broad.mit.e...
Broad MORF_TERF1 View Gene Set 4.805e-17 57 2.012e-16 102 Neighborhood of TERF1 www.broad.mit.e...
Broad GNF2_XRCC5 View Gene Set 5.498e-17 61 2.279e-16 103 Neighborhood of XRCC5 www.broad.mit.e...
Broad GCM_PFN1 View Gene Set 8.456e-17 47 3.472e-16 104 Neighborhood of PFN1 www.broad.mit.e...
Broad MORF_DEAF1 View Gene Set 1.078e-16 54 4.382e-16 105 Neighborhood of DEAF1 www.broad.mit.e...
Broad GNF2_CCNB2 View Gene Set 1.408e-16 53 5.674e-16 106 Neighborhood of CCNB2 www.broad.mit.e...
Broad GNF2_PCNA View Gene Set 1.439e-16 62 5.743e-16 107 Neighborhood of PCNA www.broad.mit.e...
Broad MORF_MSH2 View Gene Set 3.12e-16 52 1.228e-15 108 Neighborhood of MSH2 www.broad.mit.e...
Broad MORF_RPA1 View Gene Set 3.134e-16 55 1.228e-15 108 Neighborhood of RPA1 www.broad.mit.e...
Broad GNF2_DEK View Gene Set 6.008e-16 45 2.332e-15 110 Neighborhood of DEK www.broad.mit.e...
Broad GNF2_HDAC1 View Gene Set 7.371e-16 85 2.836e-15 111 Neighborhood of HDAC1 www.broad.mit.e...
Broad GNF2_MCM4 View Gene Set 8.161e-16 50 3.111e-15 112 Neighborhood of MCM4 www.broad.mit.e...
Broad MORF_BMI1 View Gene Set 1.345e-15 71 5.084e-15 113 Neighborhood of BMI1 www.broad.mit.e...
Broad MORF_BUB1B View Gene Set 1.416e-15 61 5.305e-15 114 Neighborhood of BUB1B www.broad.mit.e...
Broad MORF_RAB5A View Gene Set 1.555e-15 83 5.773e-15 115 Neighborhood of RAB5A www.broad.mit.e...
Broad GNF2_CENPF View Gene Set 1.727e-15 56 6.356e-15 116 Neighborhood of CENPF www.broad.mit.e...
Broad GNF2_FEN1 View Gene Set 6.648e-15 49 2.426e-14 117 Neighborhood of FEN1 www.broad.mit.e...
Broad MORF_BECN1 View Gene Set 7.222e-15 93 2.614e-14 118 Neighborhood of BECN1 www.broad.mit.e...
Broad MORF_GMPS View Gene Set 8.479e-15 48 3.042e-14 119 Neighborhood of GMPS www.broad.mit.e...
Broad GNF2_HMMR View Gene Set 1.22e-14 43 4.34e-14 120 Neighborhood of HMMR www.broad.mit.e...
Broad GCM_RAB10 View Gene Set 1.474e-14 143 5.2e-14 121 Neighborhood of RAB10 www.broad.mit.e...
Broad GNF2_NS View Gene Set 2.091e-14 35 7.317e-14 122 Neighborhood of NS www.broad.mit.e...
Broad MORF_BAG5 View Gene Set 3.218e-14 48 1.117e-13 123 Neighborhood of BAG5 www.broad.mit.e...
Broad MORF_XPC View Gene Set 3.461e-14 55 1.192e-13 124 Neighborhood of XPC www.broad.mit.e...
Broad GNF2_BUB1B View Gene Set 3.978e-14 46 1.359e-13 125 Neighborhood of BUB1B www.broad.mit.e...
Broad GNF2_TPT1 View Gene Set 1.074e-13 38 3.639e-13 126 Neighborhood of TPT1 www.broad.mit.e...
Broad MORF_PPP6C View Gene Set 1.157e-13 88 3.89e-13 127 Neighborhood of PPP6C www.broad.mit.e...
Broad GNF2_CDC2 View Gene Set 1.279e-13 56 4.267e-13 128 Neighborhood of CDC2 www.broad.mit.e...
Broad MORF_DAP View Gene Set 1.486e-13 72 4.92e-13 129 Neighborhood of DAP www.broad.mit.e...
Broad GCM_ANP32B View Gene Set 1.789e-13 32 5.877e-13 130 Neighborhood of ANP32B www.broad.mit.e...
Broad GNF2_RRM2 View Gene Set 2.049e-13 36 6.68e-13 131 Neighborhood of RRM2 www.broad.mit.e...
Broad GNF2_MLH1 View Gene Set 2.135e-13 36 6.905e-13 132 Neighborhood of MLH1 www.broad.mit.e...
Broad MORF_PPP2R4 View Gene Set 2.168e-13 44 6.961e-13 133 Neighborhood of PPP2R4 www.broad.mit.e...
Broad GNF2_DENR View Gene Set 2.4e-13 39 7.649e-13 134 Neighborhood of DENR www.broad.mit.e...
Broad GCM_RAF1 View Gene Set 2.475e-13 34 7.827e-13 135 Neighborhood of RAF1 www.broad.mit.e...
Broad MORF_GPX4 View Gene Set 2.557e-13 49 8.029e-13 136 Neighborhood of GPX4 www.broad.mit.e...
Broad GCM_GSPT1 View Gene Set 3.875e-13 129 1.208e-12 137 Neighborhood of GSPT1 www.broad.mit.e...
Broad GNF2_CKS2 View Gene Set 7.05e-13 45 2.181e-12 138 Neighborhood of CKS2 www.broad.mit.e...
Broad GCM_HDAC1 View Gene Set 1.242e-12 30 3.815e-12 139 Neighborhood of HDAC1 www.broad.mit.e...
Broad GNF2_MSH6 View Gene Set 2.367e-12 30 7.22e-12 140 Neighborhood of MSH6 www.broad.mit.e...
Broad GNF2_RFC3 View Gene Set 2.437e-12 38 7.38e-12 141 Neighborhood of RFC3 www.broad.mit.e...
Broad MORF_TPR View Gene Set 2.847e-12 131 8.561e-12 142 Neighborhood of TPR www.broad.mit.e...
Broad GNF2_CKS1B View Gene Set 3.981e-12 36 1.189e-11 143 Neighborhood of CKS1B www.broad.mit.e...
Broad GCM_UBE2N View Gene Set 5.229e-12 125 1.551e-11 144 Neighborhood of UBE2N www.broad.mit.e...
Broad GNF2_ESPL1 View Gene Set 5.416e-12 35 1.595e-11 145 Neighborhood of ESPL1 www.broad.mit.e...
Broad MORF_EIF4E View Gene Set 7.327e-12 76 2.143e-11 146 Neighborhood of EIF4E www.broad.mit.e...
Broad GCM_RAD21 View Gene Set 8.003e-12 30 2.325e-11 147 Neighborhood of RAD21 www.broad.mit.e...
Broad GCM_DFFA View Gene Set 1.111e-11 100 3.206e-11 148 Neighborhood of DFFA www.broad.mit.e...
Broad GNF2_UBE2I View Gene Set 1.547e-11 33 4.434e-11 149 Neighborhood of UBE2I www.broad.mit.e...
Broad MORF_GSPT1 View Gene Set 1.902e-11 41 5.415e-11 150 Neighborhood of GSPT1 www.broad.mit.e...
Broad GCM_MYST2 View Gene Set 2.029e-11 138 5.738e-11 151 Neighborhood of MYST2 www.broad.mit.e...
Broad GNF2_TTK View Gene Set 3.01e-11 34 8.455e-11 152 Neighborhood of TTK www.broad.mit.e...
Broad GNF2_CENPE View Gene Set 3.589e-11 37 1.002e-10 153 Neighborhood of CENPE www.broad.mit.e...
Broad GNF2_KPNB1 View Gene Set 4.404e-11 52 1.221e-10 154 Neighborhood of KPNB1 www.broad.mit.e...
Broad MORF_PPP2R5E View Gene Set 4.579e-11 76 1.261e-10 155 Neighborhood of PPP2R5E www.broad.mit.e...
Broad MORF_UBE2A View Gene Set 5.001e-11 44 1.369e-10 156 Neighborhood of UBE2A www.broad.mit.e...
Broad GNF2_GLTSCR2 View Gene Set 5.711e-11 31 1.553e-10 157 Neighborhood of GLTSCR2 www.broad.mit.e...
Broad MORF_RFC1 View Gene Set 6.604e-11 98 1.785e-10 158 Neighborhood of RFC1 www.broad.mit.e...
Broad GNF2_G22P1 View Gene Set 1.181e-10 29 3.171e-10 159 Neighborhood of G22P1 www.broad.mit.e...
Broad GCM_HBP1 View Gene Set 1.993e-10 54 5.319e-10 160 Neighborhood of HBP1 www.broad.mit.e...
Broad GNF2_BUB3 View Gene Set 7.698e-10 22 2.042e-09 161 Neighborhood of BUB3 www.broad.mit.e...
Broad GNF2_RBBP6 View Gene Set 8.288e-10 54 2.185e-09 162 Neighborhood of RBBP6 www.broad.mit.e...
Broad GNF2_SMC2L1 View Gene Set 1.113e-09 30 2.914e-09 163 Neighborhood of SMC2L1 www.broad.mit.e...
Broad GNF2_ANP32B View Gene Set 1.44e-09 29 3.749e-09 164 Neighborhood of ANP32B www.broad.mit.e...
Broad GNF2_MSH2 View Gene Set 1.719e-09 26 4.45e-09 165 Neighborhood of MSH2 www.broad.mit.e...
Broad GNF2_H2AFX View Gene Set 1.956e-09 28 5.032e-09 166 Neighborhood of H2AFX www.broad.mit.e...
Broad GCM_SMARCC1 View Gene Set 2.281e-09 33 5.832e-09 167 Neighborhood of SMARCC1 www.broad.mit.e...
Broad MORF_USP5 View Gene Set 2.419e-09 46 6.148e-09 168 Neighborhood of USP5 www.broad.mit.e...
Broad GCM_BMPR2 View Gene Set 2.777e-09 68 7.016e-09 169 Neighborhood of BMPR2 www.broad.mit.e...
Broad GCM_DENR View Gene Set 4.246e-09 40 1.067e-08 170 Neighborhood of DENR www.broad.mit.e...
Broad GCM_MLL View Gene Set 4.367e-09 130 1.091e-08 171 Neighborhood of MLL www.broad.mit.e...
Broad GNF2_BUB1 View Gene Set 4.485e-09 25 1.114e-08 172 Neighborhood of BUB1 www.broad.mit.e...
Broad GNF2_PPP6C View Gene Set 5.725e-09 33 1.413e-08 173 Neighborhood of PPP6C www.broad.mit.e...
Broad GNF2_TDG View Gene Set 6.614e-09 23 1.623e-08 174 Neighborhood of TDG www.broad.mit.e...
Broad MORF_IKBKG View Gene Set 7.008e-09 119 1.7e-08 175 Neighborhood of IKBKG www.broad.mit.e...
Broad GCM_RAN View Gene Set 6.991e-09 160 1.7e-08 175 Neighborhood of RAN www.broad.mit.e...
Broad GCM_TPR View Gene Set 1.024e-08 29 2.469e-08 177 Neighborhood of TPR www.broad.mit.e...
Broad MORF_SS18 View Gene Set 2.046e-08 55 4.909e-08 178 Neighborhood of SS18 www.broad.mit.e...
Broad GNF2_MKI67 View Gene Set 2.443e-08 26 5.827e-08 179 Neighborhood of MKI67 www.broad.mit.e...
Broad MORF_CSNK1D View Gene Set 2.936e-08 65 6.964e-08 180 Neighborhood of CSNK1D www.broad.mit.e...
Broad GCM_CSNK1A1 View Gene Set 6.755e-08 28 1.594e-07 181 Neighborhood of CSNK1A1 www.broad.mit.e...
Broad GCM_ERBB2IP View Gene Set 9.648e-08 57 2.264e-07 182 Neighborhood of ERBB2IP www.broad.mit.e...
Broad GCM_BCL2L1 View Gene Set 1.268e-07 25 2.959e-07 183 Neighborhood of BCL2L1 www.broad.mit.e...
Broad GCM_CALM1 View Gene Set 1.48e-07 91 3.434e-07 184 Neighborhood of CALM1 www.broad.mit.e...
Broad GCM_BECN1 View Gene Set 2.774e-07 59 6.403e-07 185 Neighborhood of BECN1 www.broad.mit.e...
Broad GCM_CHUK View Gene Set 3.631e-07 61 8.336e-07 186 Neighborhood of CHUK www.broad.mit.e...
Broad MORF_RAB11A View Gene Set 5.773e-07 53 1.318e-06 187 Neighborhood of RAB11A www.broad.mit.e...
Broad GCM_RBM8A View Gene Set 6.66e-07 64 1.513e-06 188 Neighborhood of RBM8A www.broad.mit.e...
Broad GCM_IL6ST View Gene Set 8.668e-07 48 1.958e-06 189 Neighborhood of IL6ST www.broad.mit.e...
Broad GCM_MSN View Gene Set 8.893e-07 24 1.999e-06 190 Neighborhood of MSN www.broad.mit.e...
Broad GNF2_SMC1L1 View Gene Set 1.646e-06 24 3.68e-06 191 Neighborhood of SMC1L1 www.broad.mit.e...
Broad GCM_MAX View Gene Set 1.728e-06 28 3.844e-06 192 Neighborhood of MAX www.broad.mit.e...
Broad GNF2_ELAC2 View Gene Set 1.741e-06 32 3.852e-06 193 Neighborhood of ELAC2 www.broad.mit.e...
Broad MORF_CCNF View Gene Set 3.693e-06 65 8.129e-06 194 Neighborhood of CCNF www.broad.mit.e...
Broad GCM_AIP View Gene Set 4.112e-06 36 9.004e-06 195 Neighborhood of AIP www.broad.mit.e...
Broad MORF_ARAF1 View Gene Set 7.861e-06 70 1.713e-05 196 Neighborhood of ARAF1 www.broad.mit.e...
Broad GCM_GSTA4 View Gene Set 8.191e-06 57 1.775e-05 197 Neighborhood of GSTA4 www.broad.mit.e...
Broad MORF_ORC1L View Gene Set 1.684e-05 61 3.632e-05 198 Neighborhood of ORC1L www.broad.mit.e...
Broad GNF2_BNIP2 View Gene Set 2.294e-05 31 4.923e-05 199 Neighborhood of BNIP2 www.broad.mit.e...
Broad GNF2_CBFB View Gene Set 2.501e-05 26 5.34e-05 200 Neighborhood of CBFB www.broad.mit.e...

Gene Set Collection: Broad.c4.CM

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad module_83 View Gene Set 2.799e-76 296 1.271e-73 1 Genes in module_83 www.broad.mit.e...
Broad module_114 View Gene Set 1.153e-66 314 2.618e-64 2 Genes in module_114 www.broad.mit.e...
Broad module_151 View Gene Set 1.991e-62 297 3.013e-60 3 Genes in module_151 www.broad.mit.e...
Broad module_32 View Gene Set 2.488e-56 227 2.824e-54 4 Genes in module_32 www.broad.mit.e...
Broad module_8 View Gene Set 1.919e-38 403 1.742e-36 5 Genes in module_8 www.broad.mit.e...
Broad module_17 View Gene Set 6.379e-36 351 4.827e-34 6 Genes in module_17 www.broad.mit.e...
Broad module_98 View Gene Set 7.88e-34 375 5.111e-32 7 Genes in module_98 www.broad.mit.e...
Broad module_198 View Gene Set 5.193e-31 288 2.947e-29 8 Genes in module_198 www.broad.mit.e...
Broad module_3 View Gene Set 4.552e-26 374 2.296e-24 9 Genes in module_3 www.broad.mit.e...
Broad module_54 View Gene Set 2.68e-25 242 1.217e-23 10 Genes in module_54 www.broad.mit.e...
Broad module_252 View Gene Set 4.661e-24 224 1.924e-22 11 Genes in module_252 www.broad.mit.e...
Broad module_152 View Gene Set 1.105e-22 121 4.179e-21 12 Genes in module_152 www.broad.mit.e...
Broad module_62 View Gene Set 9.903e-19 88 3.458e-17 13 Genes in module_62 www.broad.mit.e...
Broad module_159 View Gene Set 4.154e-18 81 1.347e-16 14 Genes in module_159 www.broad.mit.e...
Broad module_239 View Gene Set 5.067e-18 112 1.534e-16 15 Genes in module_239 www.broad.mit.e...
Broad module_244 View Gene Set 1.745e-16 182 4.952e-15 16 Genes in module_244 www.broad.mit.e...
Broad module_124 View Gene Set 2.944e-16 92 7.863e-15 17 Genes in module_124 www.broad.mit.e...
Broad module_149 View Gene Set 1.007e-15 36 2.539e-14 18 Genes in module_149 www.broad.mit.e...
Broad module_183 View Gene Set 1.259e-15 52 3.008e-14 19 Genes in module_183 www.broad.mit.e...
Broad module_18 View Gene Set 1.35e-14 434 3.065e-13 20 Genes in module_18 www.broad.mit.e...
Broad module_126 View Gene Set 2.734e-14 173 5.91e-13 21 Genes in module_126 www.broad.mit.e...
Broad module_115 View Gene Set 1.704e-12 27 3.516e-11 22 Genes in module_115 www.broad.mit.e...
Broad module_278 View Gene Set 1.168e-11 34 2.305e-10 23 Genes in module_278 www.broad.mit.e...
Broad module_22 View Gene Set 2.134e-11 45 4.037e-10 24 Genes in module_22 www.broad.mit.e...
Broad module_57 View Gene Set 3.441e-11 54 6.25e-10 25 Genes in module_57 www.broad.mit.e...
Broad module_219 View Gene Set 8.472e-11 26 1.479e-09 26 Genes in module_219 www.broad.mit.e...
Broad module_273 View Gene Set 1.018e-10 50 1.712e-09 27 Genes in module_273 www.broad.mit.e...
Broad module_245 View Gene Set 1.106e-10 26 1.794e-09 28 Genes in module_245 www.broad.mit.e...
Broad module_155 View Gene Set 3.51e-10 25 5.495e-09 29 Genes in module_155 www.broad.mit.e...
Broad module_91 View Gene Set 1.4e-09 37 2.118e-08 30 Genes in module_91 www.broad.mit.e...
Broad module_299 View Gene Set 1.623e-09 33 2.377e-08 31 Genes in module_299 www.broad.mit.e...
Broad module_61 View Gene Set 1.774e-09 50 2.517e-08 32 Genes in module_61 www.broad.mit.e...
Broad module_81 View Gene Set 2.462e-09 20 3.387e-08 33 Genes in module_81 www.broad.mit.e...
Broad module_29 View Gene Set 4.093e-09 28 5.466e-08 34 Genes in module_29 www.broad.mit.e...
Broad module_403 View Gene Set 4.374e-09 44 5.673e-08 35 Genes in module_403 www.broad.mit.e...
Broad module_212 View Gene Set 5.362e-09 316 6.762e-08 36 Genes in module_212 www.broad.mit.e...
Broad module_105 View Gene Set 6.52e-09 192 8.001e-08 37 Genes in module_105 www.broad.mit.e...
Broad module_72 View Gene Set 9.937e-09 293 1.176e-07 38 Genes in module_72 www.broad.mit.e...
Broad module_277 View Gene Set 1.01e-08 48 1.176e-07 38 Genes in module_277 www.broad.mit.e...
Broad module_77 View Gene Set 2.074e-08 28 2.354e-07 40 Genes in module_77 www.broad.mit.e...
Broad module_323 View Gene Set 2.553e-08 54 2.827e-07 41 Genes in module_323 www.broad.mit.e...
Broad module_93 View Gene Set 4.749e-08 180 5.133e-07 42 Genes in module_93 www.broad.mit.e...
Broad module_133 View Gene Set 6.863e-08 15 7.246e-07 43 Genes in module_133 www.broad.mit.e...
Broad module_28 View Gene Set 7.597e-08 32 7.839e-07 44 Genes in module_28 www.broad.mit.e...
Broad module_158 View Gene Set 7.977e-08 41 8.048e-07 45 Genes in module_158 www.broad.mit.e...
Broad module_363 View Gene Set 1.04e-07 48 1.027e-06 46 Genes in module_363 www.broad.mit.e...
Broad module_337 View Gene Set 1.15e-07 59 1.111e-06 47 Genes in module_337 www.broad.mit.e...
Broad module_125 View Gene Set 1.282e-07 42 1.193e-06 48 Genes in module_125 www.broad.mit.e...
Broad module_306 View Gene Set 1.287e-07 26 1.193e-06 48 Genes in module_306 www.broad.mit.e...
Broad module_82 View Gene Set 1.71e-07 24 1.552e-06 50 Genes in module_82 www.broad.mit.e...
Broad module_102 View Gene Set 3.065e-07 18 2.729e-06 51 Genes in module_102 www.broad.mit.e...
Broad module_197 View Gene Set 3.355e-07 170 2.929e-06 52 Genes in module_197 www.broad.mit.e...
Broad module_42 View Gene Set 6.808e-07 25 5.832e-06 53 Genes in module_42 www.broad.mit.e...
Broad module_308 View Gene Set 7.366e-07 66 6.193e-06 54 Genes in module_308 www.broad.mit.e...
Broad module_4 View Gene Set 7.591e-07 21 6.266e-06 55 Genes in module_4 www.broad.mit.e...
Broad module_355 View Gene Set 8.703e-07 28 7.055e-06 56 Genes in module_355 www.broad.mit.e...
Broad module_150 View Gene Set 1.265e-06 15 1.008e-05 57 Genes in module_150 www.broad.mit.e...
Broad module_43 View Gene Set 2.156e-06 97 1.659e-05 58 Genes in module_43 www.broad.mit.e...
Broad module_331 View Gene Set 2.127e-06 65 1.659e-05 58 Genes in module_331 www.broad.mit.e...
Broad module_87 View Gene Set 2.403e-06 44 1.818e-05 60 Genes in module_87 www.broad.mit.e...
Broad module_233 View Gene Set 2.631e-06 22 1.958e-05 61 Genes in module_233 www.broad.mit.e...
Broad module_160 View Gene Set 3.086e-06 15 2.26e-05 62 Genes in module_160 www.broad.mit.e...
Broad module_352 View Gene Set 3.327e-06 17 2.398e-05 63 Genes in module_352 www.broad.mit.e...
Broad module_392 View Gene Set 5.093e-06 18 3.613e-05 64 Genes in module_392 www.broad.mit.e...
Broad module_16 View Gene Set 5.423e-06 495 3.788e-05 65 Genes in module_16 www.broad.mit.e...
Broad module_56 View Gene Set 7.716e-06 12 5.308e-05 66 Genes in module_56 www.broad.mit.e...
Broad module_388 View Gene Set 7.973e-06 17 5.402e-05 67 Genes in module_388 www.broad.mit.e...
Broad module_35 View Gene Set 8.39e-06 16 5.602e-05 68 Genes in module_35 www.broad.mit.e...
Broad module_177 View Gene Set 1.07e-05 101 7.037e-05 69 Genes in module_177 www.broad.mit.e...
Broad module_110 View Gene Set 1.208e-05 15 7.834e-05 70 Genes in module_110 www.broad.mit.e...
Broad module_243 View Gene Set 1.382e-05 73 8.837e-05 71 Genes in module_243 www.broad.mit.e...
Broad module_86 View Gene Set 1.464e-05 43 9.231e-05 72 Genes in module_86 www.broad.mit.e...
Broad module_25 View Gene Set 1.591e-05 13 9.893e-05 73 Genes in module_25 www.broad.mit.e...
Broad module_325 View Gene Set 1.861e-05 46 0.0001142 74 Genes in module_325 www.broad.mit.e...
Broad module_15 View Gene Set 2.349e-05 347 0.0001422 75 Genes in module_15 www.broad.mit.e...
Broad module_147 View Gene Set 2.749e-05 102 0.0001642 76 Genes in module_147 www.broad.mit.e...
Broad module_21 View Gene Set 3.337e-05 10 0.0001968 77 Genes in module_21 www.broad.mit.e...
Broad module_429 View Gene Set 3.605e-05 14 0.0002098 78 Genes in module_429 www.broad.mit.e...
Broad module_303 View Gene Set 4.248e-05 27 0.0002441 79 Genes in module_303 www.broad.mit.e...
Broad module_451 View Gene Set 4.546e-05 29 0.000258 80 Genes in module_451 www.broad.mit.e...
Broad module_447 View Gene Set 6.169e-05 35 0.0003457 81 Genes in module_447 www.broad.mit.e...
Broad module_307 View Gene Set 7.05e-05 24 0.0003903 82 Genes in module_307 www.broad.mit.e...
Broad module_332 View Gene Set 0.0001195 35 0.0006534 83 Genes in module_332 www.broad.mit.e...
Broad module_567 View Gene Set 0.0001439 90 0.0007775 84 Genes in module_567 www.broad.mit.e...
Broad module_97 View Gene Set 0.0001647 91 0.0008799 85 Genes in module_97 www.broad.mit.e...
Broad module_52 View Gene Set 0.0001894 415 0.0009997 86 Genes in module_52 www.broad.mit.e...
Broad module_257 View Gene Set 0.0002527 137 0.001319 87 Genes in module_257 www.broad.mit.e...
Broad module_206 View Gene Set 0.000258 139 0.001331 88 Genes in module_206 www.broad.mit.e...
Broad module_116 View Gene Set 0.0002835 29 0.001446 89 Genes in module_116 www.broad.mit.e...
Broad module_31 View Gene Set 0.0003414 7 0.001712 90 Genes in module_31 www.broad.mit.e...
Broad module_503 View Gene Set 0.0003432 106 0.001712 90 Genes in module_503 www.broad.mit.e...
Broad module_568 View Gene Set 0.00049 70 0.002418 92 Genes in module_568 www.broad.mit.e...
Broad module_281 View Gene Set 0.000548 28 0.002675 93 Genes in module_281 www.broad.mit.e...
Broad module_576 View Gene Set 0.0005954 104 0.002876 94 Genes in module_576 www.broad.mit.e...
Broad module_50 View Gene Set 0.0006511 13 0.003112 95 Genes in module_50 www.broad.mit.e...
Broad module_350 View Gene Set 0.0006722 57 0.003179 96 Genes in module_350 www.broad.mit.e...
Broad module_195 View Gene Set 0.0008554 138 0.004003 97 Genes in module_195 www.broad.mit.e...
Broad module_485 View Gene Set 0.0009679 44 0.004484 98 Genes in module_485 www.broad.mit.e...
Broad module_182 View Gene Set 0.0009995 94 0.004584 99 Genes in module_182 www.broad.mit.e...
Broad module_356 View Gene Set 0.00111 141 0.005041 100 Genes in module_356 www.broad.mit.e...
Broad module_36 View Gene Set 0.001377 146 0.006129 101 Genes in module_36 www.broad.mit.e...
Broad module_226 View Gene Set 0.001377 27 0.006129 101 Genes in module_226 www.broad.mit.e...
Broad module_318 View Gene Set 0.001789 28 0.007883 103 Genes in module_318 www.broad.mit.e...
Broad module_491 View Gene Set 0.001948 74 0.008505 104 Genes in module_491 www.broad.mit.e...
Broad module_221 View Gene Set 0.002475 30 0.0107 105 Genes in module_221 www.broad.mit.e...
Broad module_179 View Gene Set 0.002527 404 0.01082 106 Genes in module_179 www.broad.mit.e...
Broad module_286 View Gene Set 0.003161 37 0.01341 107 Genes in module_286 www.broad.mit.e...
Broad module_103 View Gene Set 0.003268 12 0.01374 108 Genes in module_103 www.broad.mit.e...
Broad module_184 View Gene Set 0.004292 29 0.01788 109 Genes in module_184 www.broad.mit.e...
Broad module_457 View Gene Set 0.004674 9 0.01929 110 Genes in module_457 www.broad.mit.e...
Broad module_37 View Gene Set 0.004986 412 0.02039 111 Genes in module_37 www.broad.mit.e...
Broad module_305 View Gene Set 0.005048 19 0.02046 112 Genes in module_305 www.broad.mit.e...
Broad module_229 View Gene Set 0.005221 31 0.02098 113 Genes in module_229 www.broad.mit.e...
Broad module_532 View Gene Set 0.006268 346 0.02496 114 Genes in module_532 www.broad.mit.e...
Broad module_255 View Gene Set 0.007669 386 0.03027 115 Genes in module_255 www.broad.mit.e...
Broad module_136 View Gene Set 0.008167 426 0.03197 116 Genes in module_136 www.broad.mit.e...
Broad module_317 View Gene Set 0.008771 377 0.03403 117 Genes in module_317 www.broad.mit.e...
Broad module_538 View Gene Set 0.01001 8 0.03851 118 Genes in module_538 www.broad.mit.e...
Broad module_414 View Gene Set 0.01041 17 0.0397 119 Genes in module_414 www.broad.mit.e...
Broad module_450 View Gene Set 0.01112 9 0.04208 120 Genes in module_450 www.broad.mit.e...
Broad module_315 View Gene Set 0.01132 15 0.04247 121 Genes in module_315 www.broad.mit.e...
Broad module_378 View Gene Set 0.01148 372 0.04261 122 Genes in module_378 www.broad.mit.e...
Broad module_459 View Gene Set 0.01154 370 0.04261 122 Genes in module_459 www.broad.mit.e...
Broad module_349 View Gene Set 0.01168 17 0.04276 124 Genes in module_349 www.broad.mit.e...
Broad module_312 View Gene Set 0.01213 45 0.04404 125 Genes in module_312 www.broad.mit.e...

Gene Set Collection: Broad.c5.BP

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 2.102e-32 1197 1.734e-29 1 Genes annotated by the GO term GO:0006139. The chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad BIOPOLYMER_METABOLIC_PROCESS View Gene Set 2.682e-31 1623 1.106e-28 2 Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers long repeating chains of monomers found in nature e.g. polysaccharides and proteins. www.broad.mit.e...
Broad RNA_METABOLIC_PROCESS View Gene Set 1.584e-20 801 4.356e-18 3 Genes annotated by the GO term GO:0016070. The chemical reactions and pathways involving RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. www.broad.mit.e...
Broad CELLULAR_PROTEIN_METABOLIC_PROCESS View Gene Set 1.179e-19 1085 2.431e-17 4 Genes annotated by the GO term GO:0044267. The chemical reactions and pathways involving a specific protein rather than of proteins in general occurring at the level of an individual cell. Includes protein modification. www.broad.mit.e...
Broad PROTEIN_METABOLIC_PROCESS View Gene Set 1.881e-19 1198 3.104e-17 5 Genes annotated by the GO term GO:0019538. The chemical reactions and pathways involving a specific protein rather than of proteins in general. Includes protein modification. www.broad.mit.e...
Broad RNA_PROCESSING View Gene Set 2.355e-19 147 3.239e-17 6 Genes annotated by the GO term GO:0006396. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. www.broad.mit.e...
Broad CELLULAR_MACROMOLECULE_METABOLIC_PROCESS View Gene Set 3.145e-19 1099 3.706e-17 7 Genes annotated by the GO term GO:0044260. The chemical reactions and pathways involving macromolecules large molecules including proteins nucleic acids and carbohydrates as carried out by individual cells. www.broad.mit.e...
Broad CELLULAR_BIOSYNTHETIC_PROCESS View Gene Set 6.446e-18 311 6.647e-16 8 Genes annotated by the GO term GO:0044249. The chemical reactions and pathways resulting in the formation of substances carried out by individual cells. www.broad.mit.e...
Broad BIOSYNTHETIC_PROCESS View Gene Set 5.704e-17 459 5.229e-15 9 Genes annotated by the GO term GO:0009058. The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones as in growth and other biosynthetic processes. www.broad.mit.e...
Broad TRANSLATION View Gene Set 3.816e-16 177 3.149e-14 10 Genes annotated by the GO term GO:0006412. The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. www.broad.mit.e...
Broad DNA_METABOLIC_PROCESS View Gene Set 1.515e-15 253 1.136e-13 11 Genes annotated by the GO term GO:0006259. The chemical reactions and pathways involving DNA deoxyribonucleic acid one of the two main types of nucleic acid consisting of a long unbranched macromolecule formed from one or more commonly two strands of linked deoxyribonucleotides. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS_AND_ASSEMBLY View Gene Set 3.913e-14 74 2.69e-12 12 Genes annotated by the GO term GO:0022613. The cellular process by which a complex containing RNA and proteins is synthesized aggregates and bonds together. www.broad.mit.e...
Broad PROTEIN_FOLDING View Gene Set 7.97e-14 56 4.782e-12 13 Genes annotated by the GO term GO:0006457. The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. www.broad.mit.e...
Broad MACROMOLECULE_BIOSYNTHETIC_PROCESS View Gene Set 8.115e-14 313 4.782e-12 13 Genes annotated by the GO term GO:0009059. The chemical reactions and pathways resulting in the formation of macromolecules large molecules including proteins nucleic acids and carbohydrates. www.broad.mit.e...
Broad PROTEIN_RNA_COMPLEX_ASSEMBLY View Gene Set 1.116e-12 59 6.137e-11 15 Genes annotated by the GO term GO:0022618. The aggregation arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. www.broad.mit.e...
Broad INTRACELLULAR_TRANSPORT View Gene Set 2.435e-12 271 1.256e-10 16 Genes annotated by the GO term GO:0046907. The directed movement of substances within a cell. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX_ASSEMBLY View Gene Set 2.002e-11 271 9.177e-10 17 Genes annotated by the GO term GO:0065003. The aggregation arrangement and bonding together of a set of macromolecules to form a complex. www.broad.mit.e...
Broad CELL_CYCLE_GO_0007049 View Gene Set 1.957e-11 304 9.177e-10 17 Genes annotated by the GO term GO:0007049. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. www.broad.mit.e...
Broad CATABOLIC_PROCESS View Gene Set 1.623e-10 221 7.045e-09 19 Genes annotated by the GO term GO:0009056. The chemical reactions and pathways resulting in the breakdown of substances including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. www.broad.mit.e...
Broad RNA_SPLICING View Gene Set 1.773e-10 73 7.312e-09 20 Genes annotated by the GO term GO:0008380. The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. www.broad.mit.e...
Broad CELL_CYCLE_PROCESS View Gene Set 4.137e-10 187 1.625e-08 21 Genes annotated by the GO term GO:0022402. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad CELLULAR_COMPONENT_ASSEMBLY View Gene Set 4.634e-10 288 1.738e-08 22 Genes annotated by the GO term GO:0022607. A cellular process that results in the assembly of a part of the cell. www.broad.mit.e...
Broad CELLULAR_CATABOLIC_PROCESS View Gene Set 7.1e-10 209 2.547e-08 23 Genes annotated by the GO term GO:0044248. The chemical reactions and pathways resulting in the breakdown of substances carried out by individual cells. www.broad.mit.e...
Broad INTRACELLULAR_PROTEIN_TRANSPORT View Gene Set 1.479e-09 138 5.085e-08 24 Genes annotated by the GO term GO:0006886. The directed movement of proteins in a cell including the movement of proteins between specific compartments or structures within a cell such as organelles of a eukaryotic cell. www.broad.mit.e...
Broad DNA_REPLICATION View Gene Set 1.721e-09 101 5.678e-08 25 Genes annotated by the GO term GO:0006260. The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. www.broad.mit.e...
Broad ESTABLISHMENT_OF_CELLULAR_LOCALIZATION View Gene Set 2.049e-09 342 6.503e-08 26 Genes annotated by the GO term GO:0051649. The directed movement of a substance or cellular entity such as a protein complex or organelle to a specific location within or in the membrane of a cell. www.broad.mit.e...
Broad TRANSLATIONAL_INITIATION View Gene Set 2.238e-09 39 6.838e-08 27 Genes annotated by the GO term GO:0006413. The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome mRNA and an initiation complex that contains the first aminoacyl-tRNA. www.broad.mit.e...
Broad PROTEIN_TRANSPORT View Gene Set 3.763e-09 150 1.109e-07 28 Genes annotated by the GO term GO:0015031. The directed movement of proteins into out of within or between cells. www.broad.mit.e...
Broad MITOTIC_CELL_CYCLE View Gene Set 6.73e-09 148 1.914e-07 29 Genes annotated by the GO term GO:0000278. Progression through the phases of the mitotic cell cycle the most common eukaryotic cell cycle which canonically comprises four successive phases called G1 S G2 and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division or G1 and G2 phases may be absent. www.broad.mit.e...
Broad RESPONSE_TO_DNA_DAMAGE_STIMULUS View Gene Set 7.15e-09 159 1.966e-07 30 Genes annotated by the GO term GO:0006974. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. www.broad.mit.e...
Broad CELLULAR_LOCALIZATION View Gene Set 7.599e-09 360 2.014e-07 31 Genes annotated by the GO term GO:0051641. The processes by which a substance or cellular entity such as a protein complex or organelle is transported to and/or maintained in a specific location within or in the membrane of a cell. www.broad.mit.e...
Broad MRNA_METABOLIC_PROCESS View Gene Set 7.811e-09 70 2.014e-07 31 Genes annotated by the GO term GO:0016071. The chemical reactions and pathways involving mRNA messenger RNA which is responsible for carrying the coded genetic 'message' transcribed from DNA to sites of protein assembly at the ribosomes. www.broad.mit.e...
Broad CHROMOSOME_ORGANIZATION_AND_BIOGENESIS View Gene Set 1.198e-08 117 2.994e-07 33 Genes annotated by the GO term GO:0051276. A process that is carried out at the cellular level that results in the formation arrangement of constituent parts or disassembly of chromosomes structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. www.broad.mit.e...
Broad ORGANELLE_ORGANIZATION_AND_BIOGENESIS View Gene Set 1.288e-08 458 3.125e-07 34 Genes annotated by the GO term GO:0006996. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of any organelle within a cell. www.broad.mit.e...
Broad MACROMOLECULE_LOCALIZATION View Gene Set 1.947e-08 228 4.59e-07 35 Genes annotated by the GO term GO:0033036. The processes by which a macromolecule is transported to or maintained in a specific location. www.broad.mit.e...
Broad MRNA_PROCESSING_GO_0006397 View Gene Set 3.344e-08 59 7.664e-07 36 Genes annotated by the GO term GO:0006397. Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. www.broad.mit.e...
Broad RESPONSE_TO_ENDOGENOUS_STIMULUS View Gene Set 3.662e-08 197 8.164e-07 37 Genes annotated by the GO term GO:0009719. A change in state or activity of a cell or an organism (in terms of movement secretion enzyme production gene expression etc.) as a result of an endogenous stimulus. www.broad.mit.e...
Broad CELL_CYCLE_PHASE View Gene Set 3.771e-08 167 8.186e-07 38 Genes annotated by the GO term GO:0022403. A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events. www.broad.mit.e...
Broad TRANSCRIPTION_DNA_DEPENDENT View Gene Set 4.022e-08 623 8.295e-07 39 Genes annotated by the GO term GO:0006351. The synthesis of RNA on a template of DNA. www.broad.mit.e...
Broad RNA_BIOSYNTHETIC_PROCESS View Gene Set 3.924e-08 625 8.295e-07 39 Genes annotated by the GO term GO:0032774. The chemical reactions and pathways resulting in the formation of RNA ribonucleic acid one of the two main type of nucleic acid consisting of a long unbranched macromolecule formed from ribonucleotides joined in 3' 5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. www.broad.mit.e...
Broad MACROMOLECULE_CATABOLIC_PROCESS View Gene Set 5.347e-08 135 1.076e-06 41 Genes annotated by the GO term GO:0009057. The chemical reactions and pathways resulting in the breakdown of a macromolecule any large molecule including proteins nucleic acids and carbohydrates. www.broad.mit.e...
Broad BIOPOLYMER_CATABOLIC_PROCESS View Gene Set 6.922e-08 115 1.36e-06 42 Genes annotated by the GO term GO:0043285. The chemical reactions and pathways resulting in the breakdown of biopolymers long repeating chains of monomers found in nature e.g. polysaccharides and proteins. www.broad.mit.e...
Broad TRANSCRIPTION View Gene Set 8.178e-08 738 1.569e-06 43 Genes annotated by the GO term GO:0006350. The synthesis of either RNA on a template of DNA or DNA on a template of RNA. www.broad.mit.e...
Broad DNA_REPAIR View Gene Set 1.209e-07 123 2.267e-06 44 Genes annotated by the GO term GO:0006281. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations chemical mutagens fungal and bacterial toxins etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal base excision repair nucleotide excision repair photoreactivation bypass double-strand break repair pathway and mismatch repair pathway. www.broad.mit.e...
Broad PROTEIN_LOCALIZATION View Gene Set 1.462e-07 207 2.68e-06 45 Genes annotated by the GO term GO:0008104. The processes by which a protein is transported to or maintained in a specific location. www.broad.mit.e...
Broad REGULATION_OF_TRANSLATIONAL_INITIATION View Gene Set 2.452e-07 31 4.398e-06 46 Genes annotated by the GO term GO:0006446. Any process that modulates the frequency rate or extent of translational initiation. www.broad.mit.e...
Broad MITOCHONDRION_ORGANIZATION_AND_BIOGENESIS View Gene Set 3.614e-07 47 6.297e-06 47 Genes annotated by the GO term GO:0007005. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of a mitochondrion; includes mitochondrial morphology and distribution and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. www.broad.mit.e...
Broad CELLULAR_MACROMOLECULE_CATABOLIC_PROCESS View Gene Set 3.664e-07 103 6.297e-06 47 Genes annotated by the GO term GO:0044265. The chemical reactions and pathways resulting in the breakdown of a macromolecule any large molecule including proteins nucleic acids and carbohydrates as carried out by individual cells. www.broad.mit.e...
Broad REGULATION_OF_CELLULAR_METABOLIC_PROCESS View Gene Set 4.176e-07 767 7.03e-06 49 Genes annotated by the GO term GO:0031323. Any process that modulates the frequency rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. www.broad.mit.e...
Broad REGULATION_OF_METABOLIC_PROCESS View Gene Set 4.765e-07 779 7.708e-06 50 Genes annotated by the GO term GO:0019222. Any process that modulates the frequency rate or extent of the chemical reactions and pathways within a cell or an organism. www.broad.mit.e...
Broad M_PHASE_OF_MITOTIC_CELL_CYCLE View Gene Set 4.698e-07 83 7.708e-06 50 Genes annotated by the GO term GO:0000087. Progression through M phase the part of the mitotic cell cycle during which mitosis takes place. www.broad.mit.e...
Broad ESTABLISHMENT_OF_PROTEIN_LOCALIZATION View Gene Set 5.215e-07 183 8.273e-06 52 Genes annotated by the GO term GO:0045184. The directed movement of a protein to a specific location. www.broad.mit.e...
Broad PROTEIN_CATABOLIC_PROCESS View Gene Set 5.499e-07 68 8.56e-06 53 Genes annotated by the GO term GO:0030163. The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native active configuration with or without the hydrolysis of peptide bonds. www.broad.mit.e...
Broad CELLULAR_PROTEIN_CATABOLIC_PROCESS View Gene Set 9.849e-07 58 1.505e-05 54 Genes annotated by the GO term GO:0044257. The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. www.broad.mit.e...
Broad TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 1.708e-06 449 2.563e-05 55 Genes annotated by the GO term GO:0006366. The synthesis of RNA from a DNA template by RNA polymerase II (Pol II) originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). www.broad.mit.e...
Broad MITOSIS View Gene Set 1.763e-06 81 2.597e-05 56 Genes annotated by the GO term GO:0007067. Progression through mitosis the division of the eukaryotic cell nucleus to produce two daughter nuclei that usually contain the identical chromosome complement to their mother. www.broad.mit.e...
Broad PROTEIN_TARGETING View Gene Set 2.854e-06 103 4.13e-05 57 Genes annotated by the GO term GO:0006605. The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif. www.broad.mit.e...
Broad ESTABLISHMENT_AND_OR_MAINTENANCE_OF_CHROMATIN_ARCHITECTURE View Gene Set 3.142e-06 72 4.47e-05 58 Genes annotated by the GO term GO:0006325. The specification formation and maintenance of the physical structure of eukaryotic chromatin. www.broad.mit.e...
Broad REGULATION_OF_GENE_EXPRESSION View Gene Set 6.867e-06 660 9.602e-05 59 Genes annotated by the GO term GO:0010468. Any process that modulates the frequency rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. www.broad.mit.e...
Broad REGULATION_OF_NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 9.349e-06 601 0.0001286 60 Genes annotated by the GO term GO:0019219. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad M_PHASE View Gene Set 9.547e-06 111 0.0001291 61 Genes annotated by the GO term GO:0000279. Progression through M phase the part of the cell cycle comprising nuclear division. www.broad.mit.e...
Broad BIOPOLYMER_MODIFICATION View Gene Set 1.071e-05 627 0.0001426 62 Genes annotated by the GO term GO:0043412. The covalent alteration of one or more monomeric units in a polypeptide polynucleotide polysaccharide or other biological polymer resulting in a change in its properties. www.broad.mit.e...
Broad DNA_DEPENDENT_DNA_REPLICATION View Gene Set 1.287e-05 55 0.0001685 63 Genes annotated by the GO term GO:0006261. The process whereby new strands of DNA are synthesized using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. www.broad.mit.e...
Broad CHROMOSOME_SEGREGATION View Gene Set 2.113e-05 31 0.0002724 64 Genes annotated by the GO term GO:0007059. The process by which genetic material in the form of chromosomes is organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad MITOCHONDRIAL_TRANSPORT View Gene Set 2.321e-05 20 0.0002946 65 Genes annotated by the GO term GO:0006839. Transport of substances into out of or within a mitochondrion. www.broad.mit.e...
Broad CHROMATIN_MODIFICATION View Gene Set 3.711e-05 50 0.0004638 66 Genes annotated by the GO term GO:0016568. The alteration of DNA or protein in chromatin which may result in changing the chromatin structure. www.broad.mit.e...
Broad UBIQUITIN_CYCLE View Gene Set 3.859e-05 48 0.0004752 67 Genes annotated by the GO term GO:0006512. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDE_AND_NUCLEOTIDE_METABOLIC_PROCESS View Gene Set 4.459e-05 50 0.000541 68 Genes annotated by the GO term GO:0055086. The chemical reactions and pathways involving nucleobases nucleosides and nucleotides. www.broad.mit.e...
Broad PROTEIN_MODIFICATION_PROCESS View Gene Set 4.735e-05 610 0.0005661 69 Genes annotated by the GO term GO:0006464. The covalent alteration of one or more amino acids occurring in proteins peptides and nascent polypeptides (co-translational post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS View Gene Set 5.581e-05 205 0.0006578 70 Genes annotated by the GO term GO:0045934. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving nucleobases nucleosides nucleotides and nucleic acids. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_CELLULAR_PROCESS View Gene Set 6.478e-05 629 0.0007528 71 Genes annotated by the GO term GO:0048523. Any process that stops prevents or reduces the frequency rate or extent of cellular processes those that are carried out at the cellular level but are not necessarily restricted to a single cell. For example cell communication occurs among more than one cell but occurs at the cellular level. www.broad.mit.e...
Broad PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION View Gene Set 6.745e-05 43 0.0007728 72 Genes annotated by the GO term GO:0032446. A process by which one or more moieties of a small protein such as ubiquitin or a ubiquitin-like protein are covalently attached to a target protein. www.broad.mit.e...
Broad AMINO_ACID_METABOLIC_PROCESS View Gene Set 8.167e-05 75 0.0009229 73 Genes annotated by the GO term GO:0006520. The chemical reactions and pathways involving amino acids organic acids containing one or more amino substituents. www.broad.mit.e...
Broad PROTEIN_TARGETING_TO_MITOCHONDRION View Gene Set 8.337e-05 10 0.0009295 74 Genes annotated by the GO term GO:0006626. The process of directing proteins towards and into the mitochondrion mediated by mitochondrial proteins that recognize signals contained within the imported protein. www.broad.mit.e...
Broad PROTEIN_UBIQUITINATION View Gene Set 9.569e-05 40 0.001053 75 Genes annotated by the GO term GO:0016567. The process by which one or more ubiquitin moieties are added to a protein. www.broad.mit.e...
Broad NUCLEAR_TRANSPORT View Gene Set 0.0001078 84 0.001171 76 Genes annotated by the GO term GO:0051169. The directed movement of substances into out of or within the nucleus. www.broad.mit.e...
Broad RIBOSOME_BIOGENESIS_AND_ASSEMBLY View Gene Set 0.0001199 14 0.001285 77 Genes annotated by the GO term GO:0042254. The process of the formation of the constituents of the ribosome subunits their assembly and their transport to the sites of protein synthesis. www.broad.mit.e...
Broad TRNA_METABOLIC_PROCESS View Gene Set 0.0001318 18 0.001394 78 Genes annotated by the GO term GO:0006399. The chemical reactions and pathways involving tRNA transfer RNA a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases the function of which has not been completely established. www.broad.mit.e...
Broad INTERPHASE View Gene Set 0.0001448 68 0.001512 79 Genes annotated by the GO term GO:0051325. Progression through interphase the stage of cell cycle between successive rounds of chromosome segregation. Canonically interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. www.broad.mit.e...
Broad ORGANIC_ACID_METABOLIC_PROCESS View Gene Set 0.0001513 175 0.001522 80 Genes annotated by the GO term GO:0006082. The chemical reactions and pathways involving organic acids any acidic compound containing carbon in covalent linkage. www.broad.mit.e...
Broad CELL_CYCLE_CHECKPOINT_GO_0000075 View Gene Set 0.000149 47 0.001522 80 Genes annotated by the GO term GO:0000075. A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. www.broad.mit.e...
Broad REGULATION_OF_RNA_METABOLIC_PROCESS View Gene Set 0.0001502 457 0.001522 80 Genes annotated by the GO term GO:0051252. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving RNA. www.broad.mit.e...
Broad RNA_SPLICINGVIA_TRANSESTERIFICATION_REACTIONS View Gene Set 0.000154 27 0.001531 83 Genes annotated by the GO term GO:0000375. Splicing of RNA via a series of two transesterification reactions. www.broad.mit.e...
Broad NUCLEOCYTOPLASMIC_TRANSPORT View Gene Set 0.0001877 83 0.001844 84 Genes annotated by the GO term GO:0006913. The directed movement of molecules between the nucleus and the cytoplasm. www.broad.mit.e...
Broad PROTEIN_COMPLEX_ASSEMBLY View Gene Set 0.0002286 167 0.002219 85 Genes annotated by the GO term GO:0006461. The aggregation arrangement and bonding together of a set of components to form a protein complex. www.broad.mit.e...
Broad REGULATION_OF_DNA_METABOLIC_PROCESS View Gene Set 0.0002477 44 0.002376 86 Genes annotated by the GO term GO:0051052. Any process that modulates the frequency rate or extent of the chemical reactions and pathways involving DNA. www.broad.mit.e...
Broad APOPTOSIS_GO View Gene Set 0.0002595 423 0.002461 87 Genes annotated by the GO term GO:0006915. A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. www.broad.mit.e...
Broad CARBOXYLIC_ACID_METABOLIC_PROCESS View Gene Set 0.0002639 173 0.002474 88 Genes annotated by the GO term GO:0019752. The chemical reactions and pathways involving carboxylic acids any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). www.broad.mit.e...
Broad CELLULAR_PROTEIN_COMPLEX_ASSEMBLY View Gene Set 0.0002829 33 0.002605 89 Genes annotated by the GO term GO:0043623. The aggregation arrangement and bonding together of a set of components to form a protein complex occurring at the level of an individual cell. www.broad.mit.e...
Broad INTERPHASE_OF_MITOTIC_CELL_CYCLE View Gene Set 0.0002842 62 0.002605 89 Genes annotated by the GO term GO:0051329. Progression through interphase the stage of cell cycle between successive rounds of mitosis. Canonically interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. www.broad.mit.e...
Broad RRNA_PROCESSING View Gene Set 0.0002952 11 0.002676 91 Genes annotated by the GO term GO:0006364. Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. www.broad.mit.e...
Broad PROGRAMMED_CELL_DEATH View Gene Set 0.0003353 424 0.003004 92 Genes annotated by the GO term GO:0012501. Cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTIONDNA_DEPENDENT View Gene Set 0.0003387 452 0.003004 92 Genes annotated by the GO term GO:0006355. Any process that modulates the frequency rate or extent of DNA-dependent transcription. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTION View Gene Set 0.0003485 555 0.003059 94 Genes annotated by the GO term GO:0045449. Any process that modulates the frequency rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_APOPTOSIS View Gene Set 0.0003854 147 0.003347 95 Genes annotated by the GO term GO:0043066. Any process that stops prevents or reduces the frequency rate or extent of cell death by apoptosis. www.broad.mit.e...
Broad REGULATION_OF_CELL_CYCLE View Gene Set 0.0003923 176 0.003372 96 Genes annotated by the GO term GO:0051726. Any process that modulates the rate or extent of progression through the cell cycle. www.broad.mit.e...
Broad PROTEIN_EXPORT_FROM_NUCLEUS View Gene Set 0.0004176 10 0.003552 97 Genes annotated by the GO term GO:0006611. The directed movement of a protein from the nucleus into the cytoplasm. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_CELLULAR_METABOLIC_PROCESS View Gene Set 0.000448 252 0.003771 98 Genes annotated by the GO term GO:0031324. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. www.broad.mit.e...
Broad COFACTOR_METABOLIC_PROCESS View Gene Set 0.0004599 53 0.003833 99 Genes annotated by the GO term GO:0051186. The chemical reactions and pathways involving a cofactor a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic such as the metal atoms zinc iron and copper in certain forms or organic in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. www.broad.mit.e...
Broad DOUBLE_STRAND_BREAK_REPAIR View Gene Set 0.0004872 22 0.00398 100 Genes annotated by the GO term GO:0006302. The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. www.broad.mit.e...
Broad REGULATION_OF_APOPTOSIS View Gene Set 0.0004848 335 0.00398 100 Genes annotated by the GO term GO:0042981. Any process that modulates the occurrence or rate of cell death by apoptosis. www.broad.mit.e...
Broad POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE View Gene Set 0.0005188 80 0.004196 102 Genes annotated by the GO term GO:0043123. Any process that activates or increases the frequency rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. www.broad.mit.e...
Broad ANTI_APOPTOSIS View Gene Set 0.0005601 115 0.004486 103 Genes annotated by the GO term GO:0006916. A process which directly inhibits any of the steps required for cell death by apoptosis. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_METABOLIC_PROCESS View Gene Set 0.0005965 255 0.004687 104 Genes annotated by the GO term GO:0009892. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways within a cell or an organism. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH View Gene Set 0.0005939 148 0.004687 104 Genes annotated by the GO term GO:0043069. Any process that stops prevents or reduces the frequency rate or extent of programmed cell death cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad REGULATION_OF_PROGRAMMED_CELL_DEATH View Gene Set 0.0006386 336 0.00497 106 Genes annotated by the GO term GO:0043067. Any process that modulates the frequency rate or extent of programmed cell death cell death resulting from activation of endogenous cellular processes. www.broad.mit.e...
Broad RRNA_METABOLIC_PROCESS View Gene Set 0.000664 12 0.00512 107 Genes annotated by the GO term GO:0016072. The chemical reactions and pathways involving rRNA ribosomal RNA a structural constituent of ribosomes. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_TRANSCRIPTION View Gene Set 0.0006712 185 0.005128 108 Genes annotated by the GO term GO:0016481. Any process that stops prevents or reduces the frequency rate or extent of transcription. www.broad.mit.e...
Broad ONE_CARBON_COMPOUND_METABOLIC_PROCESS View Gene Set 0.0007398 26 0.005599 109 Genes annotated by the GO term GO:0006730. The chemical reactions and pathways involving compounds containing a single carbon atom. www.broad.mit.e...
Broad REGULATION_OF_GENE_EXPRESSION_EPIGENETIC View Gene Set 0.0007701 30 0.005776 110 Genes annotated by the GO term GO:0040029. Any process that modulates the frequency rate or extent of gene expression; the process is mitotically or meiotically heritable or is stably self-propagated in the cytoplasm of a resting cell and does not entail a change in DNA sequence. www.broad.mit.e...
Broad NITROGEN_COMPOUND_METABOLIC_PROCESS View Gene Set 0.000788 150 0.005857 111 Genes annotated by the GO term GO:0006807. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation nitrification denitrification assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. www.broad.mit.e...
Broad GOLGI_VESICLE_TRANSPORT View Gene Set 0.0008217 47 0.006053 112 Genes annotated by the GO term GO:0048193. The directed movement of substances into out of or within the Golgi apparatus mediated by vesicles. www.broad.mit.e...
Broad CHROMOSOME_CONDENSATION View Gene Set 0.0008372 10 0.006112 113 Genes annotated by the GO term GO:0030261. The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division or during apoptosis in eukaryotic cells. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_BIOLOGICAL_PROCESS View Gene Set 0.0008703 659 0.006298 114 Genes annotated by the GO term GO:0048519. Any process that stops prevents or reduces the frequency rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression protein modification or interaction with a protein or substrate molecule. www.broad.mit.e...
Broad CHROMATIN_ASSEMBLY_OR_DISASSEMBLY View Gene Set 0.0009869 26 0.00708 115 Genes annotated by the GO term GO:0006333. The formation or destruction of chromatin structures. www.broad.mit.e...
Broad REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 0.001167 285 0.008302 116 Genes annotated by the GO term GO:0006357. Any process that modulates the frequency rate or extent of transcription from an RNA polymerase II promoter. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS View Gene Set 0.001253 17 0.008839 117 Genes annotated by the GO term GO:0051053. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving DNA. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_TRANSCRIPTION_DNA_DEPENDENT View Gene Set 0.001288 127 0.008927 118 Genes annotated by the GO term GO:0045892. Any process that stops prevents or reduces the frequency rate or extent of DNA-dependent transcription. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS View Gene Set 0.001288 127 0.008927 118 Genes annotated by the GO term GO:0051253. Any process that stops prevents or reduces the frequency rate or extent of the chemical reactions and pathways involving RNA. www.broad.mit.e...
Broad DNA_RECOMBINATION View Gene Set 0.001414 47 0.009721 120 Genes annotated by the GO term GO:0006310. The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment intrachromosomal recombination or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation conjugation transduction or F-duction. www.broad.mit.e...
Broad PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS View Gene Set 0.001457 9 0.009934 121 Genes annotated by the GO term GO:0006220. The chemical reactions and pathways involving a pyrimidine nucleotide a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. www.broad.mit.e...
Broad SISTER_CHROMATID_SEGREGATION View Gene Set 0.001608 17 0.01087 122 Genes annotated by the GO term GO:0000819. The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets. www.broad.mit.e...
Broad CHROMATIN_REMODELING View Gene Set 0.001744 23 0.0117 123 Genes annotated by the GO term GO:0006338. Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. www.broad.mit.e...
Broad MITOTIC_SISTER_CHROMATID_SEGREGATION View Gene Set 0.001778 16 0.01183 124 Genes annotated by the GO term GO:0000070. The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome composed of two sister chromatids aligns at the cell equator paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. www.broad.mit.e...
Broad AMINO_ACID_AND_DERIVATIVE_METABOLIC_PROCESS View Gene Set 0.001881 98 0.01241 125 Genes annotated by the GO term GO:0006519. The chemical reactions and pathways involving amino acids organic acids containing one or more amino substituents and compounds derived from amino acids. www.broad.mit.e...
Broad ER_NUCLEAR_SIGNALING_PATHWAY View Gene Set 0.002147 16 0.01405 126 Genes annotated by the GO term GO:0006984. Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus usually resulting in a change in transcriptional regulation. www.broad.mit.e...
Broad ESTABLISHMENT_OF_ORGANELLE_LOCALIZATION View Gene Set 0.002383 17 0.01548 127 Genes annotated by the GO term GO:0051656. The directed movement of an organelle to a specific location. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_DNA_REPLICATION View Gene Set 0.002409 12 0.01553 128 Genes annotated by the GO term GO:0008156. Any process that stops prevents or reduces the frequency rate or extent of DNA replication. www.broad.mit.e...
Broad NITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS View Gene Set 0.002575 25 0.01647 129 Genes annotated by the GO term GO:0044271. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. www.broad.mit.e...
Broad UNFOLDED_PROTEIN_RESPONSE View Gene Set 0.002698 10 0.01712 130 Genes annotated by the GO term GO:0030968. The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. www.broad.mit.e...
Broad G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE View Gene Set 0.002757 27 0.01736 131 Genes annotated by the GO term GO:0000082. Progression from G1 phase to S phase of the mitotic cell cycle. www.broad.mit.e...
Broad COENZYME_METABOLIC_PROCESS View Gene Set 0.002976 37 0.0186 132 Genes annotated by the GO term GO:0006732. The chemical reactions and pathways involving coenzymes any of various nonprotein organic cofactors that are required in addition to an enzyme and a substrate for an enzymatic reaction to proceed. www.broad.mit.e...
Broad NUCLEOTIDE_METABOLIC_PROCESS View Gene Set 0.003422 40 0.02123 133 Genes annotated by the GO term GO:0009117. The chemical reactions and pathways involving a nucleotide a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono- di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). www.broad.mit.e...
Broad NUCLEOTIDE_SUGAR_METABOLIC_PROCESS View Gene Set 0.003624 9 0.02231 134 Genes annotated by the GO term GO:0009225. The chemical reactions and pathways involving nucleotide-sugars any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. www.broad.mit.e...
Broad AEROBIC_RESPIRATION View Gene Set 0.003851 15 0.02353 135 Genes annotated by the GO term GO:0009060. The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. www.broad.mit.e...
Broad VIRAL_GENOME_REPLICATION View Gene Set 0.004265 21 0.02581 136 Genes annotated by the GO term GO:0019079. Any process involved directly in viral genome replication including viral nucleotide metabolism. www.broad.mit.e...
Broad NUCLEAR_EXPORT View Gene Set 0.004286 31 0.02581 136 Genes annotated by the GO term GO:0051168. The directed movement of substances out of the nucleus. www.broad.mit.e...
Broad I_KAPPAB_KINASE_NF_KAPPAB_CASCADE View Gene Set 0.004323 107 0.02584 138 Genes annotated by the GO term GO:0007249. A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. www.broad.mit.e...
Broad AGING View Gene Set 0.004451 12 0.02642 139 Genes annotated by the GO term GO:0007568. The inherent decline over time from the optimal fertility and viability of early maturity that may precede death and may be preceded by other indications such as sterility. www.broad.mit.e...
Broad DNA_REPLICATION_INITIATION View Gene Set 0.005007 15 0.0295 140 Genes annotated by the GO term GO:0006270. The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix the recruitment of DNA polymerases and the initiation of polymerase action. www.broad.mit.e...
Broad POST_TRANSLATIONAL_PROTEIN_MODIFICATION View Gene Set 0.005127 462 0.03 141 Genes annotated by the GO term GO:0043687. The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_TRANSPORT View Gene Set 0.005246 31 0.03048 142 Genes annotated by the GO term GO:0015931. The directed movement of nucleobases nucleosides nucleotides and nucleic acids into out of within or between cells. www.broad.mit.e...
Broad LIPID_BIOSYNTHETIC_PROCESS View Gene Set 0.00529 97 0.03052 143 Genes annotated by the GO term GO:0008610. The chemical reactions and pathways resulting in the formation of lipids compounds soluble in an organic solvent but not or sparingly in an aqueous solvent. www.broad.mit.e...
Broad PROTEOLYSIS View Gene Set 0.005635 187 0.03228 144 Genes annotated by the GO term GO:0006508. The hydrolysis of a peptide bond or bonds within a protein. www.broad.mit.e...
Broad VESICLE_MEDIATED_TRANSPORT View Gene Set 0.005884 188 0.03348 145 Genes annotated by the GO term GO:0016192. The directed movement of substances either within a vesicle or in the vesicle membrane into out of or within a cell. www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.005945 11 0.03359 146 Genes annotated by the GO term GO:0007006. A process that is carried out at the cellular level which results in the formation arrangement of constituent parts or disassembly of the mitochondrial membrane the lipid bilayer surrounding a mitochondrion. www.broad.mit.e...
Broad REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE View Gene Set 0.006009 86 0.03373 147 Genes annotated by the GO term GO:0043122. Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade. www.broad.mit.e...
Broad CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY View Gene Set 0.006129 13 0.03417 148 Genes annotated by the GO term GO:0043624. The disaggregation of a protein complex into its constituent components occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad TRANSPORT View Gene Set 0.006416 777 0.03552 149 Genes annotated by the GO term GO:0006810. The directed movement of substances (such as macromolecules small molecules ions) into out of within or between cells. www.broad.mit.e...
Broad SPLICEOSOME_ASSEMBLY View Gene Set 0.00664 13 0.03652 150 Genes annotated by the GO term GO:0000245. The aggregation arrangement and bonding together of the spliceosome a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. www.broad.mit.e...
Broad HISTONE_MODIFICATION View Gene Set 0.006781 22 0.03705 151 Genes annotated by the GO term GO:0016570. The covalent alteration of one or more amino acid residues within a histone protein. www.broad.mit.e...
Broad CYTOKINESIS View Gene Set 0.006882 19 0.03735 152 Genes annotated by the GO term GO:0000910. A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth replication and segregation of cellular components. www.broad.mit.e...
Broad RIBONUCLEOTIDE_METABOLIC_PROCESS View Gene Set 0.006993 14 0.03771 153 Genes annotated by the GO term GO:0009259. The chemical reactions and pathways involving a ribonucleotide a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. www.broad.mit.e...
Broad COVALENT_CHROMATIN_MODIFICATION View Gene Set 0.007156 23 0.03834 154 Genes annotated by the GO term GO:0016569. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. www.broad.mit.e...
Broad PROTEIN_IMPORT View Gene Set 0.007428 59 0.03942 155 Genes annotated by the GO term GO:0017038. The directed movement of proteins into a cell or organelle. www.broad.mit.e...
Broad REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESIS View Gene Set 0.007454 124 0.03942 155 Genes annotated by the GO term GO:0051128. Any process that modulates the frequency rate or extent of the processes involved in the formation arrangement of constituent parts or disassembly of cell structures including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. www.broad.mit.e...
Broad NITROGEN_COMPOUND_CATABOLIC_PROCESS View Gene Set 0.007521 28 0.03952 157 Genes annotated by the GO term GO:0044270. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. www.broad.mit.e...
Broad GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY View Gene Set 0.007771 122 0.04058 158 Genes annotated by the GO term GO:0006091. The chemical reactions and pathways resulting in the formation of precursor metabolites substances from which energy is derived and the processes involved in the liberation of energy from these substances. www.broad.mit.e...
Broad POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION View Gene Set 0.008041 119 0.04146 159 Genes annotated by the GO term GO:0009967. Any process that activates or increases the frequency rate or extent of signal transduction. www.broad.mit.e...
Broad NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER View Gene Set 0.00803 83 0.04146 159 Genes annotated by the GO term GO:0000122. Any process that stops prevents or reduces the frequency rate or extent of transcription from an RNA polymerase II promoter. www.broad.mit.e...
Broad ESTABLISHMENT_OF_LOCALIZATION View Gene Set 0.008303 851 0.04255 161 Genes annotated by the GO term GO:0051234. The directed movement of a cell substance or cellular entity such as a protein complex or organelle to a specific location. www.broad.mit.e...
Broad BASE_EXCISION_REPAIR View Gene Set 0.008372 16 0.04263 162 Genes annotated by the GO term GO:0006284. In base excision repair an altered base is removed by a DNA glycosylase enzyme followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. www.broad.mit.e...
Broad GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS View Gene Set 0.008831 14 0.0447 163 Genes annotated by the GO term GO:0009064. The chemical reactions and pathways involving amino acids of the glutamine family comprising arginine glutamate glutamine and proline. www.broad.mit.e...
Broad PROTEIN_COMPLEX_DISASSEMBLY View Gene Set 0.009037 14 0.04491 164 Genes annotated by the GO term GO:0043241. The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad CELLULAR_RESPONSE_TO_STIMULUS View Gene Set 0.008948 19 0.04491 164 Genes annotated by the GO term GO:0051716. A change in state or activity of a cell (in terms of movement secretion enzyme production gene expression etc.) as a result of a stimulus. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX_DISASSEMBLY View Gene Set 0.009037 15 0.04491 164 Genes annotated by the GO term GO:0032984. The disaggregation of a macromolecular complex into its constituent components. www.broad.mit.e...
Broad CELL_PROLIFERATION_GO_0008283 View Gene Set 0.009128 501 0.0451 167 Genes annotated by the GO term GO:0008283. The multiplication or reproduction of cells resulting in the expansion of a cell population. www.broad.mit.e...
Broad CELLULAR_COMPONENT_DISASSEMBLY View Gene Set 0.009415 33 0.04623 168 Genes annotated by the GO term GO:0022411. A cellular process that results in the breakdown of a part of the cell. www.broad.mit.e...
Broad TRNA_PROCESSING View Gene Set 0.009894 10 0.0483 169 Genes annotated by the GO term GO:0008033. The process by which a pre-tRNA molecule is converted to a mature tRNA ready for addition of an aminoacyl group. www.broad.mit.e...
Broad DNA_INTEGRITY_CHECKPOINT View Gene Set 0.01008 23 0.04892 170 Genes annotated by the GO term GO:0031570. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. www.broad.mit.e...

Gene Set Collection: Broad.c5.CC

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad CYTOPLASM View Gene Set 1.151e-59 2054 2.681e-57 1 Genes annotated by the GO term GO:0005737. All of the contents of a cell excluding the plasma membrane and nucleus but including other subcellular structures. www.broad.mit.e...
Broad NUCLEUS View Gene Set 5.701e-59 1353 6.642e-57 2 Genes annotated by the GO term GO:0005634. A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells the nucleus contains all of the cell's chromosomes except the organellar chromosomes and is the site of RNA synthesis and processing. In some species or in specialized cell types RNA metabolism or DNA replication may be absent. www.broad.mit.e...
Broad INTRACELLULAR_ORGANELLE_PART View Gene Set 6.593e-58 1144 5.12e-56 3 Genes annotated by the GO term GO:0044446. A constituent part of an intracellular organelle an organized structure of distinctive morphology and function occurring within the cell. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad ORGANELLE_PART View Gene Set 3.605e-57 1149 2.1e-55 4 Genes annotated by the GO term GO:0044422. Any constituent part of an organelle an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus mitochondria plastids vacuoles vesicles ribosomes and the cytoskeleton but excludes the plasma membrane. www.broad.mit.e...
Broad CYTOPLASMIC_PART View Gene Set 8.662e-47 1350 4.037e-45 5 Genes annotated by the GO term GO:0044444. Any constituent part of the cytoplasm all of the contents of a cell excluding the plasma membrane and nucleus but including other subcellular structures. www.broad.mit.e...
Broad NUCLEAR_PART View Gene Set 9.74e-33 543 3.782e-31 6 Genes annotated by the GO term GO:0044428. Any constituent part of the nucleus a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. www.broad.mit.e...
Broad MACROMOLECULAR_COMPLEX View Gene Set 6.083e-30 914 2.025e-28 7 Genes annotated by the GO term GO:0032991. A stable assembly of two or more macromolecules i.e. proteins nucleic acids carbohydrates or lipids in which the constituent parts function together. www.broad.mit.e...
Broad ORGANELLE_MEMBRANE View Gene Set 1.163e-26 290 3.388e-25 8 Genes annotated by the GO term GO:0031090. The lipid bilayer surrounding an organelle. www.broad.mit.e...
Broad ORGANELLE_LUMEN View Gene Set 1.107e-25 434 2.345e-24 9 Genes annotated by the GO term GO:0043233. The volume enclosed by the membranes of a particular organelle e.g. endoplasmic reticulum lumen or the space between the two lipid bilayers of a double membrane surrounding an organelle e.g. nuclear membrane lumen. www.broad.mit.e...
Broad MEMBRANE_ENCLOSED_LUMEN View Gene Set 1.107e-25 434 2.345e-24 9 Genes annotated by the GO term GO:0031974. The enclosed volume within a sealed membrane or between two sealed membranes. www.broad.mit.e...
Broad MITOCHONDRION View Gene Set 1.103e-25 335 2.345e-24 9 Genes annotated by the GO term GO:0005739. A semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_COMPLEX View Gene Set 6.737e-23 129 1.308e-21 12 Genes annotated by the GO term GO:0030529. A macromolecular complex containing both protein and RNA molecules. www.broad.mit.e...
Broad NUCLEAR_LUMEN View Gene Set 4.109e-20 365 7.365e-19 13 Genes annotated by the GO term GO:0031981. The volume enclosed by the nuclear inner membrane. www.broad.mit.e...
Broad ENVELOPE View Gene Set 6.576e-20 165 1.021e-18 14 Genes annotated by the GO term GO:0031975. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers and may include a cell wall layer also includes the space between layers. www.broad.mit.e...
Broad ORGANELLE_ENVELOPE View Gene Set 6.576e-20 165 1.021e-18 14 Genes annotated by the GO term GO:0031967. A double membrane structure enclosing an organelle including two lipid bilayers and the region between them. In some cases an organelle envelope may have more than two membranes. www.broad.mit.e...
Broad MITOCHONDRIAL_PART View Gene Set 8.311e-19 140 1.21e-17 16 Genes annotated by the GO term GO:0044429. Any constituent part of a mitochondrion a semiautonomous self replicating organelle that occurs in varying numbers shapes and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. www.broad.mit.e...
Broad NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 1.238e-18 613 1.602e-17 17 Genes annotated by the GO term GO:0043228. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad INTRACELLULAR_NON_MEMBRANE_BOUND_ORGANELLE View Gene Set 1.238e-18 613 1.602e-17 17 Genes annotated by the GO term GO:0043232. Organized structure of distinctive morphology and function not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes the cytoskeleton and chromosomes. www.broad.mit.e...
Broad ENDOMEMBRANE_SYSTEM View Gene Set 4.148e-18 213 4.902e-17 19 Genes annotated by the GO term GO:0012505. A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum Golgi bodies vesicles cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. www.broad.mit.e...
Broad PROTEIN_COMPLEX View Gene Set 4.208e-18 799 4.902e-17 19 Genes annotated by the GO term GO:0043234. Any protein group composed of two or more subunits which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups such as nucleic acids metal ions or carbohydrate groups. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM View Gene Set 2.996e-15 282 3.324e-14 21 Genes annotated by the GO term GO:0005783. The irregular network of unit membranes visible only by electron microscopy that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels which are often expanded into slitlike cavities called cisternae. The ER takes two forms rough (or granular) with ribosomes adhering to the outer surface and smooth (with no ribosomes attached). www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE View Gene Set 1.543e-14 85 1.634e-13 22 Genes annotated by the GO term GO:0031966. Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad MITOCHONDRIAL_ENVELOPE View Gene Set 2.358e-13 95 2.389e-12 23 Genes annotated by the GO term GO:0005740. The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. www.broad.mit.e...
Broad NUCLEOLUS View Gene Set 1.008e-12 116 9.784e-12 24 Genes annotated by the GO term GO:0005730. A small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA the processing of this RNA into 5.8S 18S and 28S components of ribosomal RNA and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. www.broad.mit.e...
Broad NUCLEOPLASM View Gene Set 2.029e-12 266 1.891e-11 25 Genes annotated by the GO term GO:0005654. That part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_PART View Gene Set 6.448e-11 93 5.779e-10 26 Genes annotated by the GO term GO:0044432. Any constituent part of the endoplasmic reticulum the irregular network of unit membranes visible only by electron microscopy that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels which are often expanded into slitlike cavities called cisternae. www.broad.mit.e...
Broad MITOCHONDRIAL_INNER_MEMBRANE View Gene Set 1.605e-10 66 1.385e-09 27 Genes annotated by the GO term GO:0005743. The inner i.e. lumen-facing lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. www.broad.mit.e...
Broad ORGANELLE_INNER_MEMBRANE View Gene Set 3.383e-10 74 2.718e-09 28 Genes annotated by the GO term GO:0019866. The inner i.e. lumen-facing lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. www.broad.mit.e...
Broad MITOCHONDRIAL_MEMBRANE_PART View Gene Set 3.274e-10 52 2.718e-09 28 Genes annotated by the GO term GO:0044455. Any constituent part of the mitochondrial membrane either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. www.broad.mit.e...
Broad CHROMOSOME View Gene Set 5.714e-10 122 4.438e-09 30 Genes annotated by the GO term GO:0005694. A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad RIBOSOME View Gene Set 1.553e-09 39 1.167e-08 31 Genes annotated by the GO term GO:0005840. An intracellular organelle about 200 A in diameter consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits one large and one small each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients expressed in Svedberg units (symbol: S). Hence the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes eukaryotes mitochondria and chloroplasts have characteristically distinct ribosomal proteins. www.broad.mit.e...
Broad NUCLEAR_ENVELOPE_ENDOPLASMIC_RETICULUM_NETWORK View Gene Set 6.194e-09 91 4.51e-08 32 Genes annotated by the GO term GO:0042175. The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 1.061e-08 82 7.494e-08 33 Genes annotated by the GO term GO:0005789. The lipid bilayer surrounding the endoplasmic reticulum. www.broad.mit.e...
Broad NUCLEAR_ENVELOPE View Gene Set 1.219e-08 71 8.354e-08 34 Genes annotated by the GO term GO:0005635. The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space a gap of width 20-40 nm (also called the perinuclear space). www.broad.mit.e...
Broad CHROMOSOMAL_PART View Gene Set 3.44e-08 95 2.29e-07 35 Genes annotated by the GO term GO:0044427. Any constituent part of a chromosome a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. www.broad.mit.e...
Broad SPLICEOSOME View Gene Set 1.388e-07 44 8.984e-07 36 Genes annotated by the GO term GO:0005681. A ribonucleoprotein complex containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. www.broad.mit.e...
Broad MITOCHONDRIAL_MATRIX View Gene Set 1.908e-07 46 1.17e-06 37 Genes annotated by the GO term GO:0005759. The gel-like material with considerable fine structure that lies in the matrix space or lumen of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and in some organisms the enzymes concerned with fatty-acid oxidation. www.broad.mit.e...
Broad MITOCHONDRIAL_LUMEN View Gene Set 1.908e-07 46 1.17e-06 37 Genes annotated by the GO term GO:0031980. The volume enclosed by the mitochondrial inner membrane. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE View Gene Set 3.049e-07 48 1.822e-06 39 Genes annotated by the GO term GO:0031965. Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. www.broad.mit.e...
Broad GOLGI_APPARATUS View Gene Set 3.67e-07 222 2.138e-06 40 Genes annotated by the GO term GO:0005794. A compound membranous cytoplasmic organelle of eukaryotic cells consisting of flattened ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle while in invertebrates and plants where they are known usually as dictyosomes there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis in the vicinity of the cis face trans in the vicinity of the trans face and medial lying between the cis and trans regions. www.broad.mit.e...
Broad NUCLEOPLASM_PART View Gene Set 3.873e-07 202 2.201e-06 41 Genes annotated by the GO term GO:0044451. Any constituent part of the nucleoplasm that part of the nuclear content other than the chromosomes or the nucleolus. www.broad.mit.e...
Broad GOLGI_APPARATUS_PART View Gene Set 4.033e-07 98 2.237e-06 42 Genes annotated by the GO term GO:0044431. Any constituent part of the Golgi apparatus a compound membranous cytoplasmic organelle of eukaryotic cells consisting of flattened ribosome-free vesicles arranged in a more or less regular stack. www.broad.mit.e...
Broad NUCLEAR_PORE View Gene Set 8.752e-07 29 4.742e-06 43 Genes annotated by the GO term GO:0005643. Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell where the inner and outer nuclear membranes are joined. www.broad.mit.e...
Broad NUCLEAR_MEMBRANE_PART View Gene Set 9.936e-07 40 5.262e-06 44 Genes annotated by the GO term GO:0044453. Any constituent part of the nuclear membrane the envelope that surrounds the nucleus of eukaryotic cells. www.broad.mit.e...
Broad SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 1.09e-06 20 5.523e-06 45 Genes annotated by the GO term GO:0030532. A complex composed of RNA of the small nuclear RNA (snRNA) class and protein found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain e.g. U1 snRNP or U4/U6 snRNP. Many but not all of these complexes are involved in splicing of nuclear mRNAs. www.broad.mit.e...
Broad PROTEASOME_COMPLEX View Gene Set 1.069e-06 23 5.523e-06 45 Genes annotated by the GO term GO:0000502. A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. www.broad.mit.e...
Broad HETEROGENEOUS_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX View Gene Set 2.225e-06 9 1.103e-05 47 Genes annotated by the GO term GO:0030530. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II that which is translated into protein) with protein which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. www.broad.mit.e...
Broad RIBOSOMAL_SUBUNIT View Gene Set 5.688e-06 20 2.761e-05 48 Genes annotated by the GO term GO:0033279. Either of the two ribonucleoprotein complexes that associate to form a ribosome. www.broad.mit.e...
Broad PORE_COMPLEX View Gene Set 6.775e-06 34 3.221e-05 49 Genes annotated by the GO term GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids. www.broad.mit.e...
Broad INTEGRAL_TO_ORGANELLE_MEMBRANE View Gene Set 8.804e-06 49 4.022e-05 50 Genes annotated by the GO term GO:0031301. Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. www.broad.mit.e...
Broad INTRINSIC_TO_ORGANELLE_MEMBRANE View Gene Set 8.768e-06 51 4.022e-05 50 Genes annotated by the GO term GO:0031300. Located in an organelle membrane such that some covalently attached portion of the gene product for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor spans or is embedded in one or both leaflets of the membrane. www.broad.mit.e...
Broad ORGANELLAR_RIBOSOME View Gene Set 2.322e-05 22 0.0001021 52 Genes annotated by the GO term GO:0000313. A ribosome contained within a subcellular organelle. www.broad.mit.e...
Broad MITOCHONDRIAL_RIBOSOME View Gene Set 2.322e-05 22 0.0001021 52 Genes annotated by the GO term GO:0005761. A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. www.broad.mit.e...
Broad GOLGI_MEMBRANE View Gene Set 2.672e-05 43 0.0001153 54 Genes annotated by the GO term GO:0000139. The lipid bilayer surrounding any of the compartments of the Golgi apparatus. www.broad.mit.e...
Broad MITOCHONDRIAL_OUTER_MEMBRANE View Gene Set 3.398e-05 18 0.0001439 55 Genes annotated by the GO term GO:0005741. The outer i.e. cytoplasm-facing lipid bilayer of the mitochondrial envelope. www.broad.mit.e...
Broad OLIGOSACCHARYL_TRANSFERASE_COMPLEX View Gene Set 4.672e-05 9 0.0001944 56 Genes annotated by the GO term GO:0008250. A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits at least in yeast. www.broad.mit.e...
Broad INTRINSIC_TO_ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 5.2e-05 24 0.0002089 57 Genes annotated by the GO term GO:0031227. Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor spans or is embedded in one or both leaflets of the membrane. www.broad.mit.e...
Broad INTEGRAL_TO_ENDOPLASMIC_RETICULUM_MEMBRANE View Gene Set 5.2e-05 24 0.0002089 57 Genes annotated by the GO term GO:0030176. Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. www.broad.mit.e...
Broad OUTER_MEMBRANE View Gene Set 6.986e-05 25 0.0002759 59 Genes annotated by the GO term GO:0019867. The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. www.broad.mit.e...
Broad SPINDLE View Gene Set 0.0001092 37 0.0004242 60 Genes annotated by the GO term GO:0005819. The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. www.broad.mit.e...
Broad ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001181 11 0.0004368 61 Genes annotated by the GO term GO:0000314. The smaller of the two subunits of an organellar ribosome. www.broad.mit.e...
Broad MITOCHONDRIAL_SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001181 11 0.0004368 61 Genes annotated by the GO term GO:0005763. The smaller of the two subunits of a mitochondrial ribosome. www.broad.mit.e...
Broad SMALL_RIBOSOMAL_SUBUNIT View Gene Set 0.0001181 11 0.0004368 61 Genes annotated by the GO term GO:0015935. The smaller of the two subunits of a ribosome. www.broad.mit.e...
Broad CYTOSOL View Gene Set 0.00015 203 0.000546 64 Genes annotated by the GO term GO:0005829. That part of the cytoplasm that does not contain membranous or particulate subcellular components. www.broad.mit.e...
Broad MITOCHONDRIAL_RESPIRATORY_CHAIN View Gene Set 0.0001766 24 0.0006235 65 Genes annotated by the GO term GO:0005746. The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I III and IV can transport protons if embedded in an oriented membrane such as an intact mitochondrial inner membrane. www.broad.mit.e...
Broad ENDOPLASMIC_RETICULUM_LUMEN View Gene Set 0.0001764 12 0.0006235 65 Genes annotated by the GO term GO:0005788. The volume enclosed by the membranes of the endoplasmic reticulum. www.broad.mit.e...
Broad ORGANELLE_OUTER_MEMBRANE View Gene Set 0.0002 24 0.0006955 67 Genes annotated by the GO term GO:0031968. The outer i.e. cytoplasm-facing lipid bilayer of an organelle envelope. www.broad.mit.e...
Broad EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX View Gene Set 0.0002051 10 0.0007029 68 Genes annotated by the GO term GO:0005852. A complex of several polypeptides that plays at least two important roles in protein synthesis: First eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME View Gene Set 0.000275 53 0.0009288 69 Genes annotated by the GO term GO:0000228. A chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad KINETOCHORE View Gene Set 0.0003246 25 0.001074 70 Genes annotated by the GO term GO:0000776. A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. www.broad.mit.e...
Broad ER_GOLGI_INTERMEDIATE_COMPARTMENT View Gene Set 0.0003274 22 0.001074 70 Genes annotated by the GO term GO:0005793. A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex with a distinctive membrane protein composition; involved in ER-to-Golgi transport. www.broad.mit.e...
Broad CHROMATIN View Gene Set 0.0004093 35 0.001325 72 Genes annotated by the GO term GO:0000785. The ordered and organized complex of DNA and protein that forms the chromosome. www.broad.mit.e...
Broad MICROTUBULE View Gene Set 0.0004407 31 0.001407 73 Genes annotated by the GO term GO:0005874. Any of the long generally straight hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation e.g. in the spindle. www.broad.mit.e...
Broad CONDENSED_CHROMOSOME View Gene Set 0.0004952 32 0.001559 74 Genes annotated by the GO term GO:0000793. A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. www.broad.mit.e...
Broad CHROMOSOMEPERICENTRIC_REGION View Gene Set 0.00059 31 0.001833 75 Genes annotated by the GO term GO:0000775. The central region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes this region corresponds to a single area of the chromosome whereas in holocentric chromosomes it is evenly distributed along the chromosome. www.broad.mit.e...
Broad MICROTUBULE_CYTOSKELETON View Gene Set 0.0006831 146 0.002094 76 Genes annotated by the GO term GO:0015630. The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. www.broad.mit.e...
Broad ENDOSOME View Gene Set 0.0006978 64 0.002112 77 Genes annotated by the GO term GO:0005768. A membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation. www.broad.mit.e...
Broad SPINDLE_MICROTUBULE View Gene Set 0.0007254 15 0.002167 78 Genes annotated by the GO term GO:0005876. Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. www.broad.mit.e...
Broad GOLGI_ASSOCIATED_VESICLE View Gene Set 0.0008545 27 0.00252 79 Genes annotated by the GO term GO:0005798. Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. www.broad.mit.e...
Broad CYTOSKELETON View Gene Set 0.0009906 359 0.002885 80 Genes annotated by the GO term GO:0005856. Any of the various filamentous elements that form the internal framework of cells and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments microfilaments microtubules the microtrabecular lattice and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions including cellular movement cell division endocytosis and movement of organelles. www.broad.mit.e...
Broad PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX View Gene Set 0.001066 15 0.003066 81 Genes annotated by the GO term GO:0016469. A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0 V0 or A0) that carries out proton transport and a cytoplasmic compartment sector (F1 V1 or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient whereas F-type ATPases also known as ATP synthases normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type A-type ATPases have been found in archaea and are closely related to eukaryotic V-type ATPases but are reversible. www.broad.mit.e...
Broad TRANSCRIPTION_FACTOR_COMPLEX View Gene Set 0.00115 84 0.003266 82 Genes annotated by the GO term GO:0005667. Any complex distinct from RNA polymerase including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences and regulating transcription. www.broad.mit.e...
Broad NUCLEOLAR_PART View Gene Set 0.001258 16 0.00353 83 Genes annotated by the GO term GO:0044452. Any constituent part of a nucleolus a small dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein is not bounded by a limiting membrane and is not seen during mitosis. www.broad.mit.e...
Broad REPLICATION_FORK View Gene Set 0.001367 18 0.003792 84 Genes annotated by the GO term GO:0005657. The Y-shaped region of a replicating DNA molecule resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. www.broad.mit.e...
Broad UBIQUITIN_LIGASE_COMPLEX View Gene Set 0.001518 26 0.004161 85 Genes annotated by the GO term GO:0000151. A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex. www.broad.mit.e...
Broad GOLGI_STACK View Gene Set 0.001696 13 0.004596 86 Genes annotated by the GO term GO:0005795. The set of thin flattened membrane-bounded compartments called cisternae that form the central portion of the Golgi complex. The stack usually comprises cis medial and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. www.broad.mit.e...
Broad EARLY_ENDOSOME View Gene Set 0.001798 18 0.004816 87 Genes annotated by the GO term GO:0005769. Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered. www.broad.mit.e...
Broad MICROBODY View Gene Set 0.002264 46 0.005928 88 Genes annotated by the GO term GO:0042579. Cytoplasmic organelles spherical or oval in shape that are bounded by a single membrane and contain oxidative enzymes especially those utilizing hydrogen peroxide (H2O2). www.broad.mit.e...
Broad PEROXISOME View Gene Set 0.002264 46 0.005928 88 Genes annotated by the GO term GO:0005777. A small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). www.broad.mit.e...
Broad NADH_DEHYDROGENASE_COMPLEX View Gene Set 0.002962 15 0.007501 90 Genes annotated by the GO term GO:0030964. An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone. www.broad.mit.e...
Broad MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I View Gene Set 0.002962 15 0.007501 90 Genes annotated by the GO term GO:0005747. A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits including NADH dehydrogenase (ubiquinone) flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III) and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. www.broad.mit.e...
Broad RESPIRATORY_CHAIN_COMPLEX_I View Gene Set 0.002962 15 0.007501 90 Genes annotated by the GO term GO:0045271. Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. www.broad.mit.e...
Broad NUCLEAR_BODY View Gene Set 0.003257 31 0.00816 93 Genes annotated by the GO term GO:0016604. Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. www.broad.mit.e...
Broad TRANSPORT_VESICLE View Gene Set 0.003312 29 0.00821 94 Genes annotated by the GO term GO:0030133. Any of the vesicles of the constitutive secretory pathway which carry cargo from the endoplasmic reticulum to the Golgi between Golgi cisternae and to destinations within or outside the cell. www.broad.mit.e...
Broad CYTOSKELETAL_PART View Gene Set 0.0051 231 0.01251 95 Genes annotated by the GO term GO:0044430. Any constituent part of the cytoskeleton a cellular scaffolding or skeleton that maintains cell shape enables some cell motion (using structures such as flagella and cilia) and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments microfilaments microtubules and the microtrabecular lattice. www.broad.mit.e...
Broad CYTOPLASMIC_VESICLE_MEMBRANE View Gene Set 0.007258 26 0.01726 96 Genes annotated by the GO term GO:0030659. The lipid bilayer surrounding a cytoplasmic vesicle. www.broad.mit.e...
Broad HISTONE_DEACETYLASE_COMPLEX View Gene Set 0.007209 18 0.01726 96 Genes annotated by the GO term GO:0000118. Complex that possesses histone deacetylase activity. www.broad.mit.e...
Broad CYTOPLASMIC_VESICLE_PART View Gene Set 0.007258 26 0.01726 96 Genes annotated by the GO term GO:0044433. Any constituent part of cytoplasmic vesicle a vesicle formed of membrane or protein found in the cytoplasm of a cell. www.broad.mit.e...
Broad VESICLE_MEMBRANE View Gene Set 0.007406 28 0.01743 99 Genes annotated by the GO term GO:0012506. The lipid bilayer surrounding any membrane-bounded vesicle in the cell. www.broad.mit.e...
Broad PERINUCLEAR_REGION_OF_CYTOPLASM View Gene Set 0.008359 55 0.01948 100 Genes annotated by the GO term GO:0048471. Cytoplasm situated near or occurring around the nucleus. www.broad.mit.e...
Broad INTRINSIC_TO_GOLGI_MEMBRANE View Gene Set 0.009547 15 0.02202 101 Genes annotated by the GO term GO:0031228. Located in the Golgi membrane such that some covalently attached portion of the gene product for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor spans or is embedded in one or both leaflets of the membrane. www.broad.mit.e...
Broad TRANS_GOLGI_NETWORK View Gene Set 0.01317 21 0.03009 102 Genes annotated by the GO term GO:0005802. The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. www.broad.mit.e...
Broad NUCLEAR_CHROMOSOME_PART View Gene Set 0.01364 33 0.03085 103 Genes annotated by the GO term GO:0044454. Any constituent part of a nuclear chromosome a chromosome found in the nucleus of a eukaryotic cell. www.broad.mit.e...
Broad COATED_VESICLE View Gene Set 0.01415 45 0.0317 104 Genes annotated by the GO term GO:0030135. Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin whereas others are made from other proteins. www.broad.mit.e...
Broad TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE View Gene Set 0.01622 11 0.03599 105 Genes annotated by the GO term GO:0030140. A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. www.broad.mit.e...
Broad NUCLEAR_UBIQUITIN_LIGASE_COMPLEX View Gene Set 0.01669 11 0.03668 106 Genes annotated by the GO term GO:0000152. A ubiquitin ligase complex found in the nucleus. www.broad.mit.e...
Broad PML_BODY View Gene Set 0.01941 13 0.04226 107 Genes annotated by the GO term GO:0016605. A class of nuclear body; they react against SP100 auto-antibodies (PML promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. www.broad.mit.e...
Broad MEMBRANE_BOUND_VESICLE View Gene Set 0.02208 113 0.04763 108 Genes annotated by the GO term GO:0031988. Any small fluid-filled spherical organelle enclosed by a lipid bilayer. www.broad.mit.e...
Broad CYTOPLASMIC_MEMBRANE_BOUND_VESICLE View Gene Set 0.02332 111 0.04985 109 Genes annotated by the GO term GO:0016023. A membrane-bound vesicle found in the cytoplasm of the cell. www.broad.mit.e...

Gene Set Collection: Broad.c5.MF

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Broad RNA_BINDING View Gene Set 7.234e-39 236 2.865e-36 1 Genes annotated by the GO term GO:0003723. Interacting selectively with an RNA molecule or a portion thereof. www.broad.mit.e...
Broad STRUCTURAL_CONSTITUENT_OF_RIBOSOME View Gene Set 3.088e-22 80 6.115e-20 2 Genes annotated by the GO term GO:0003735. The action of a molecule that contributes to the structural integrity of the ribosome. www.broad.mit.e...
Broad TRANSLATION_FACTOR_ACTIVITY_NUCLEIC_ACID_BINDING View Gene Set 7.14e-11 39 9.425e-09 3 Genes annotated by the GO term GO:0008135. Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad TRANSLATION_REGULATOR_ACTIVITY View Gene Set 1.674e-10 41 1.657e-08 4 Genes annotated by the GO term GO:0045182. Any substance involved in the initiation activation perpetuation repression or termination of polypeptide synthesis at the ribosome. www.broad.mit.e...
Broad HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES View Gene Set 2.814e-10 224 2.229e-08 5 Genes annotated by the GO term GO:0016817. Catalysis of the hydrolysis of any acid anhydride. www.broad.mit.e...
Broad PYROPHOSPHATASE_ACTIVITY View Gene Set 5.957e-10 222 3.931e-08 6 Genes annotated by the GO term GO:0016462. Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups leaving one phosphate on each of the two fragments. www.broad.mit.e...
Broad TRANSLATION_INITIATION_FACTOR_ACTIVITY View Gene Set 1.955e-09 24 1.106e-07 7 Genes annotated by the GO term GO:0003743. Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. www.broad.mit.e...
Broad NUCLEOSIDE_TRIPHOSPHATASE_ACTIVITY View Gene Set 2.333e-09 208 1.155e-07 8 Genes annotated by the GO term GO:0017111. Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. www.broad.mit.e...
Broad LIGASE_ACTIVITY View Gene Set 3.948e-08 97 1.737e-06 9 Genes annotated by the GO term GO:0016874. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. www.broad.mit.e...
Broad UNFOLDED_PROTEIN_BINDING View Gene Set 4.99e-08 41 1.976e-06 10 Genes annotated by the GO term GO:0051082. Interacting selectively with an unfolded protein. www.broad.mit.e...
Broad TRANSCRIPTION_FACTOR_BINDING View Gene Set 4.176e-07 300 1.503e-05 11 Genes annotated by the GO term GO:0008134. Interacting selectively with a transcription factor any protein required to initiate or regulate transcription. www.broad.mit.e...
Broad STRUCTURE_SPECIFIC_DNA_BINDING View Gene Set 6.483e-07 55 2.061e-05 12 Genes annotated by the GO term GO:0043566. Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. www.broad.mit.e...
Broad ATPASE_ACTIVITY View Gene Set 6.767e-07 109 2.061e-05 12 Genes annotated by the GO term GO:0016887. Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. www.broad.mit.e...
Broad SIGNAL_SEQUENCE_BINDING View Gene Set 9.465e-07 15 2.677e-05 14 Genes annotated by the GO term GO:0005048. Interacting selectively with a signal sequence a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. www.broad.mit.e...
Broad DNA_BINDING View Gene Set 1.897e-06 587 5.009e-05 15 Genes annotated by the GO term GO:0003677. Interacting selectively with DNA (deoxyribonucleic acid). www.broad.mit.e...
Broad SINGLE_STRANDED_DNA_BINDING View Gene Set 4.111e-06 34 0.0001017 16 Genes annotated by the GO term GO:0003697. Interacting selectively with single-stranded DNA. www.broad.mit.e...
Broad HELICASE_ACTIVITY View Gene Set 1.162e-05 49 0.0002706 17 Genes annotated by the GO term GO:0004386. Catalysis of the unwinding of a DNA or RNA duplex. www.broad.mit.e...
Broad MRNA_BINDING View Gene Set 3.158e-05 22 0.0006949 18 Genes annotated by the GO term GO:0003729. Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA). www.broad.mit.e...
Broad DAMAGED_DNA_BINDING View Gene Set 5.094e-05 21 0.0009606 19 Genes annotated by the GO term GO:0003684. Interacting selectively with damaged DNA. www.broad.mit.e...
Broad STRUCTURAL_MOLECULE_ACTIVITY View Gene Set 4.795e-05 243 0.0009606 19 Genes annotated by the GO term GO:0005198. The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. www.broad.mit.e...
Broad LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS View Gene Set 4.96e-05 14 0.0009606 19 Genes annotated by the GO term GO:0016875. Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage usually in a nucleoside triphosphate. www.broad.mit.e...
Broad ATP_DEPENDENT_HELICASE_ACTIVITY View Gene Set 9.633e-05 26 0.001659 22 Genes annotated by the GO term GO:0008026. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. www.broad.mit.e...
Broad ATPASE_ACTIVITY_COUPLED View Gene Set 9.501e-05 92 0.001659 22 Genes annotated by the GO term GO:0042623. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction for example ion transport across a membrane. www.broad.mit.e...
Broad RNA_SPLICING_FACTOR_ACTIVITYTRANSESTERIFICATION_MECHANISM View Gene Set 0.0001028 14 0.001695 24 Genes annotated by the GO term GO:0031202. An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced. www.broad.mit.e...
Broad OXIDOREDUCTASE_ACTIVITY View Gene Set 0.0001311 280 0.002076 25 Genes annotated by the GO term GO:0016491. Catalysis of an oxidation-reduction (redox) reaction a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized while the other acts as hydrogen or electron acceptor and becomes reduced. www.broad.mit.e...
Broad LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS View Gene Set 0.0001536 68 0.00231 26 Genes annotated by the GO term GO:0016879. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage usually in a nucleoside triphosphate. www.broad.mit.e...
Broad DOUBLE_STRANDED_DNA_BINDING View Gene Set 0.0001633 32 0.00231 26 Genes annotated by the GO term GO:0003690. Interacting selectively with double-stranded DNA. www.broad.mit.e...
Broad CHROMATIN_BINDING View Gene Set 0.000158 32 0.00231 26 Genes annotated by the GO term GO:0003682. Interacting selectively with chromatin the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. www.broad.mit.e...
Broad TRANSCRIPTION_COFACTOR_ACTIVITY View Gene Set 0.0002102 222 0.002871 29 Genes annotated by the GO term GO:0003712. The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. www.broad.mit.e...
Broad DNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 0.0002618 22 0.003456 30 Genes annotated by the GO term GO:0008094. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. www.broad.mit.e...
Broad RNA_DEPENDENT_ATPASE_ACTIVITY View Gene Set 0.0002712 18 0.003464 31 Genes annotated by the GO term GO:0008186. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of RNA; drives another reaction. www.broad.mit.e...
Broad RNA_HELICASE_ACTIVITY View Gene Set 0.0003348 24 0.003936 32 Genes annotated by the GO term GO:0003724. Catalysis of the unwinding of an RNA helix. www.broad.mit.e...
Broad METHYLTRANSFERASE_ACTIVITY View Gene Set 0.0003379 36 0.003936 32 Genes annotated by the GO term GO:0008168. Catalysis of the transfer of a methyl group to an acceptor molecule. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS View Gene Set 0.0003319 414 0.003936 32 Genes annotated by the GO term GO:0016772. Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad GTPASE_ACTIVITY View Gene Set 0.0005149 98 0.005826 35 Genes annotated by the GO term GO:0003924. Catalysis of the reaction: GTP + H2O = GDP + phosphate. www.broad.mit.e...
Broad EXONUCLEASE_ACTIVITY View Gene Set 0.0006793 18 0.007472 36 Genes annotated by the GO term GO:0004527. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. www.broad.mit.e...
Broad NUCLEOBASENUCLEOSIDENUCLEOTIDE_KINASE_ACTIVITY View Gene Set 0.0007314 24 0.007828 37 Genes annotated by the GO term GO:0019205. Catalysis of the transfer of a phosphate group usually from ATP or GTP to a nucleobase nucleoside nucleotide or polynucleotide substrate. www.broad.mit.e...
Broad ATP_DEPENDENT_RNA_HELICASE_ACTIVITY View Gene Set 0.0007945 17 0.00828 38 Genes annotated by the GO term GO:0004004. Catalysis of the reaction: ATP + H2O = ADP + phosphate driving the unwinding of an RNA helix. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS View Gene Set 0.0009892 37 0.01004 39 Genes annotated by the GO term GO:0016741. Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad PROTEIN_HETERODIMERIZATION_ACTIVITY View Gene Set 0.001074 77 0.01064 40 Genes annotated by the GO term GO:0046982. Interacting selectively with a nonidentical protein to form a heterodimer. www.broad.mit.e...
Broad DOUBLE_STRANDED_RNA_BINDING View Gene Set 0.001205 17 0.01104 41 Genes annotated by the GO term GO:0003725. Interacting selectively with double-stranded RNA. www.broad.mit.e...
Broad TRANSITION_METAL_ION_BINDING View Gene Set 0.001216 110 0.01104 41 Genes annotated by the GO term GO:0046914. Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium manganese iron copper cobalt nickel molybdenum and silver. www.broad.mit.e...
Broad ISOMERASE_ACTIVITY View Gene Set 0.001227 34 0.01104 41 Genes annotated by the GO term GO:0016853. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. www.broad.mit.e...
Broad ENDONUCLEASE_ACTIVITY_GO_0016893 View Gene Set 0.001199 11 0.01104 41 Genes annotated by the GO term GO:0016893. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. www.broad.mit.e...
Broad NUCLEOTIDE_BINDING View Gene Set 0.001316 218 0.01158 45 Genes annotated by the GO term GO:0000166. Interacting selectively with a nucleotide any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. www.broad.mit.e...
Broad PURINE_NUCLEOTIDE_BINDING View Gene Set 0.001494 205 0.01286 46 Genes annotated by the GO term GO:0017076. Interacting selectively with purine nucleotides any compound consisting of a purine nucleoside esterified with (ortho)phosphate. www.broad.mit.e...
Broad NUCLEASE_ACTIVITY View Gene Set 0.001565 54 0.01318 47 Genes annotated by the GO term GO:0004518. Catalysis of the hydrolysis of ester linkages within nucleic acids. www.broad.mit.e...
Broad RIBONUCLEOPROTEIN_BINDING View Gene Set 0.001747 9 0.01441 48 Genes annotated by the GO term GO:0043021. Interacting selectively with any complex of RNA and protein. www.broad.mit.e...
Broad TRANSCRIPTION_COREPRESSOR_ACTIVITY View Gene Set 0.001826 91 0.01476 49 Genes annotated by the GO term GO:0003714. The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself. www.broad.mit.e...
Broad IDENTICAL_PROTEIN_BINDING View Gene Set 0.00193 300 0.01529 50 Genes annotated by the GO term GO:0042802. Interacting selectively with an identical protein or proteins. www.broad.mit.e...
Broad ELECTRON_CARRIER_ACTIVITY View Gene Set 0.001984 76 0.0154 51 Genes annotated by the GO term GO:0009055. Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. www.broad.mit.e...
Broad PURINE_RIBONUCLEOTIDE_BINDING View Gene Set 0.002142 200 0.01631 52 Genes annotated by the GO term GO:0032555. Interacting selectively with a purine ribonucleotide any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. www.broad.mit.e...
Broad PROTEIN_TRANSPORTER_ACTIVITY View Gene Set 0.002539 14 0.0182 53 Genes annotated by the GO term GO:0008565. Enables the directed movement of proteins into out of within or between cells. www.broad.mit.e...
Broad BETA_TUBULIN_BINDING View Gene Set 0.002501 10 0.0182 53 Genes annotated by the GO term GO:0048487. Interacting selectively with the microtubule constituent protein beta-tubulin. www.broad.mit.e...
Broad CHAPERONE_BINDING View Gene Set 0.002573 12 0.0182 53 Genes annotated by the GO term GO:0051087. Interacting selectively with a chaperone protein a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. www.broad.mit.e...
Broad GUANYL_NUCLEOTIDE_BINDING View Gene Set 0.002448 47 0.0182 53 Genes annotated by the GO term GO:0019001. Interacting selectively with guanyl nucleotides any compound consisting of guanosine esterified with (ortho)phosphate. www.broad.mit.e...
Broad GTP_BINDING View Gene Set 0.002944 46 0.02033 57 Genes annotated by the GO term GO:0005525. Interacting selectively with GTP guanosine triphosphate. www.broad.mit.e...
Broad INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY View Gene Set 0.002978 18 0.02033 57 Genes annotated by the GO term GO:0016860. Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule and no oxidized product appears. www.broad.mit.e...
Broad RIBONUCLEASE_ACTIVITY View Gene Set 0.003061 25 0.02054 59 Genes annotated by the GO term GO:0004540. Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. www.broad.mit.e...
Broad PROTEIN_N_TERMINUS_BINDING View Gene Set 0.003347 38 0.02192 60 Genes annotated by the GO term GO:0047485. Interacting selectively with a protein N-terminus the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYLOTHER_THAN_METHYLGROUPS View Gene Set 0.003376 30 0.02192 60 Genes annotated by the GO term GO:0016765. Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad 3_5_EXONUCLEASE_ACTIVITY View Gene Set 0.004319 12 0.02759 62 Genes annotated by the GO term GO:0008408. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. www.broad.mit.e...
Broad ACID_AMINO_ACID_LIGASE_ACTIVITY View Gene Set 0.004406 57 0.02769 63 Genes annotated by the GO term GO:0016881. Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage usually in a nucleoside triphosphate. www.broad.mit.e...
Broad DNA_HELICASE_ACTIVITY View Gene Set 0.004613 24 0.02826 64 Genes annotated by the GO term GO:0003678. Catalysis of the unwinding of a DNA duplex. www.broad.mit.e...
Broad ATP_DEPENDENT_DNA_HELICASE_ACTIVITY View Gene Set 0.004639 11 0.02826 64 Genes annotated by the GO term GO:0004003. Catalysis of the reaction: ATP + H2O = ADP + phosphate driving the unwinding of the DNA helix. www.broad.mit.e...
Broad NUCLEOTIDYLTRANSFERASE_ACTIVITY View Gene Set 0.004786 47 0.02836 66 Genes annotated by the GO term GO:0016779. Catalysis of the transfer of a nucleotidyl group to a reactant. www.broad.mit.e...
Broad NF_KAPPAB_BINDING View Gene Set 0.004799 11 0.02836 66 Genes annotated by the GO term GO:0051059. Interacting selectively with NF-kappaB a transcription factor for eukaryotic RNA polymerase II promoters. www.broad.mit.e...
Broad HORMONE_RECEPTOR_BINDING View Gene Set 0.004962 29 0.0289 68 Genes annotated by the GO term GO:0051427. Interacting selectively with a receptor for hormones. www.broad.mit.e...
Broad CYTOCHROME_C_OXIDASE_ACTIVITY View Gene Set 0.005098 13 0.02909 69 Genes annotated by the GO term GO:0004129. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. www.broad.mit.e...
Broad KINASE_ACTIVITY View Gene Set 0.005142 359 0.02909 69 Genes annotated by the GO term GO:0016301. Catalysis of the transfer of a phosphate group usually from ATP to a substrate molecule. www.broad.mit.e...
Broad ZINC_ION_BINDING View Gene Set 0.005271 89 0.0294 71 Genes annotated by the GO term GO:0008270. Interacting selectively with zinc (Zn) ions. www.broad.mit.e...
Broad DEOXYRIBONUCLEASE_ACTIVITY View Gene Set 0.005761 22 0.03168 72 Genes annotated by the GO term GO:0004536. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. www.broad.mit.e...
Broad THYROID_HORMONE_RECEPTOR_BINDING View Gene Set 0.005913 17 0.03207 73 Genes annotated by the GO term GO:0046966. Interacting selectively with a thyroid hormone receptor. www.broad.mit.e...
Broad RAS_GTPASE_BINDING View Gene Set 0.006268 24 0.03354 74 Genes annotated by the GO term GO:0017016. Interacting selectively with any member of the Ras superfamily of monomeric GTPases. www.broad.mit.e...
Broad ENDONUCLEASE_ACTIVITY View Gene Set 0.006351 25 0.03354 74 Genes annotated by the GO term GO:0004519. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. www.broad.mit.e...
Broad SMALL_PROTEIN_CONJUGATING_ENZYME_ACTIVITY View Gene Set 0.006743 52 0.03513 76 Genes annotated by the GO term GO:0008639. Catalysis of the covalent attachment of small proteins such as ubiquitin or ubiquitin-like proteins to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3 ubiquitin-like protein ligase. www.broad.mit.e...
Broad PROTEIN_PHOSPHATASE_BINDING View Gene Set 0.006927 9 0.03562 77 Genes annotated by the GO term GO:0019903. Interacting selectively with any protein phosphatase. www.broad.mit.e...
Broad ENDODEOXYRIBONUCLEASE_ACTIVITY View Gene Set 0.008198 11 0.04109 78 Genes annotated by the GO term GO:0004520. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. www.broad.mit.e...
Broad PROTEIN_C_TERMINUS_BINDING View Gene Set 0.00811 73 0.04109 78 Genes annotated by the GO term GO:0008022. Interacting selectively with a protein C-terminus the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. www.broad.mit.e...
Broad HISTONE_DEACETYLASE_BINDING View Gene Set 0.008624 8 0.04269 80 Genes annotated by the GO term GO:0042826. Interacting selectively with the enzyme histone deacetylase. www.broad.mit.e...
Broad NUCLEAR_HORMONE_RECEPTOR_BINDING View Gene Set 0.00881 28 0.04307 81 Genes annotated by the GO term GO:0035257. Interacting selectively with a nuclear hormone receptor a ligand-dependent receptor found in the nucleus of the cell. www.broad.mit.e...
Broad TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS View Gene Set 0.00923 76 0.04457 82 Genes annotated by the GO term GO:0016758. Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). www.broad.mit.e...
Broad AMINOPEPTIDASE_ACTIVITY View Gene Set 0.01042 13 0.0497 83 Genes annotated by the GO term GO:0004177. Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides. www.broad.mit.e...

Gene Set Collection: PMID

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
PMID 15635413 View Gene Set 3.739e-74 421 9.375e-71 1 Nucleolar proteome dynamics. www.ncbi.nlm.ni...
PMID 17643375 View Gene Set 7.229e-51 391 9.062e-48 2 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. www.ncbi.nlm.ni...
PMID 15302935 View Gene Set 3.724e-48 773 3.112e-45 3 Large-scale characterization of HeLa cell nuclear phosphoproteins. www.ncbi.nlm.ni...
PMID 11790298 View Gene Set 1.87e-46 208 1.172e-43 4 Directed proteomic analysis of the human nucleolus. www.ncbi.nlm.ni...
PMID 11042152 View Gene Set 7.511e-42 315 3.766e-39 5 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. www.ncbi.nlm.ni...
PMID 16964243 View Gene Set 1.518e-41 504 6.343e-39 6 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. www.ncbi.nlm.ni...
PMID 15592455 View Gene Set 9.837e-32 317 3.523e-29 7 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. www.ncbi.nlm.ni...
PMID 15189156 View Gene Set 3.378e-27 88 1.058e-24 8 The molecular mechanics of eukaryotic translation. www.ncbi.nlm.ni...
PMID 15231747 View Gene Set 4.755e-27 212 1.324e-24 9 A protein interaction framework for human mRNA degradation. www.ncbi.nlm.ni...
PMID 8722009 View Gene Set 4.708e-26 80 1.18e-23 10 Structure and evolution of mammalian ribosomal proteins. www.ncbi.nlm.ni...
PMID 16565220 View Gene Set 4.069e-25 210 9.274e-23 11 Phosphoproteome analysis of the human mitotic spindle. www.ncbi.nlm.ni...
PMID 12226669 View Gene Set 3.976e-24 108 8.307e-22 12 Comprehensive proteomic analysis of the human spliceosome. www.ncbi.nlm.ni...
PMID 17220478 View Gene Set 9.748e-24 63 1.88e-21 13 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. www.ncbi.nlm.ni...
PMID 10810093 View Gene Set 5.857e-23 151 1.049e-20 14 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. www.ncbi.nlm.ni...
PMID 9582194 View Gene Set 6.813e-22 67 1.139e-19 15 A map of 75 human ribosomal protein genes. www.ncbi.nlm.ni...
PMID 12665801 View Gene Set 8.294e-22 261 1.3e-19 16 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. www.ncbi.nlm.ni...
PMID 16236267 View Gene Set 6.149e-21 77 9.068e-19 17 Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. www.ncbi.nlm.ni...
PMID 12588972 View Gene Set 3.331e-18 56 4.64e-16 18 Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region. www.ncbi.nlm.ni...
PMID 12706105 View Gene Set 7.299e-18 182 9.631e-16 19 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. www.ncbi.nlm.ni...
PMID 14559993 View Gene Set 1.304e-16 51 1.635e-14 20 Regulation of alternative splicing by SRrp86 and its interacting proteins. www.ncbi.nlm.ni...
PMID 14567916 View Gene Set 2.639e-16 50 3.15e-14 21 Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. www.ncbi.nlm.ni...
PMID 15231748 View Gene Set 2.774e-16 519 3.161e-14 22 Functional proteomics mapping of a human signaling pathway. www.ncbi.nlm.ni...
PMID 7821789 View Gene Set 1.01e-14 59 1.101e-12 23 Construction of a human full-length cDNA bank. www.ncbi.nlm.ni...
PMID 16341674 View Gene Set 1.902e-14 392 1.986e-12 24 Transcriptome analysis of human gastric cancer. www.ncbi.nlm.ni...
PMID 11543634 View Gene Set 3.663e-14 58 3.673e-12 25 The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. www.ncbi.nlm.ni...
PMID 12429849 View Gene Set 4.514e-14 106 4.352e-12 26 Functional proteomic analysis of human nucleolus. www.ncbi.nlm.ni...
PMID 16130169 View Gene Set 6.455e-14 74 5.994e-12 27 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. www.ncbi.nlm.ni...
PMID 15324660 View Gene Set 1.062e-13 242 9.512e-12 28 Proteomic functional and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. www.ncbi.nlm.ni...
PMID 11875025 View Gene Set 2.458e-13 41 2.125e-11 29 The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. www.ncbi.nlm.ni...
PMID 14667819 View Gene Set 5.557e-13 112 4.644e-11 30 Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. www.ncbi.nlm.ni...
PMID 15489336 View Gene Set 1.037e-12 722 8.385e-11 31 From ORFeome to biology: a functional genomics pipeline. www.ncbi.nlm.ni...
PMID 11991638 View Gene Set 1.695e-12 74 1.328e-10 32 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. www.ncbi.nlm.ni...
PMID 16381901 View Gene Set 1.877e-12 720 1.426e-10 33 The LIFEdb database in 2006. www.ncbi.nlm.ni...
PMID 15782174 View Gene Set 3.011e-12 31 2.22e-10 34 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. www.ncbi.nlm.ni...
PMID 10931946 View Gene Set 3.838e-12 118 2.749e-10 35 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. www.ncbi.nlm.ni...
PMID 20085707 View Gene Set 4.083e-12 42 2.843e-10 36 Aire's partners in the molecular control of immunological tolerance. www.ncbi.nlm.ni...
PMID 19710015 View Gene Set 4.313e-12 48 2.922e-10 37 The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. www.ncbi.nlm.ni...
PMID 11256614 View Gene Set 7.391e-12 522 4.876e-10 38 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. www.ncbi.nlm.ni...
PMID 11285280 View Gene Set 8.111e-12 62 5.214e-10 39 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. www.ncbi.nlm.ni...
PMID 15952740 View Gene Set 1.009e-11 58 6.323e-10 40 Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. www.ncbi.nlm.ni...
PMID 17081065 View Gene Set 2.376e-11 80 1.453e-09 41 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. www.ncbi.nlm.ni...
PMID 19064571 View Gene Set 4.331e-11 75 2.585e-09 42 Polymorphisms in mitochondrial genes and prostate cancer risk. www.ncbi.nlm.ni...
PMID 14743216 View Gene Set 1.085e-10 132 6.324e-09 43 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. www.ncbi.nlm.ni...
PMID 16303743 View Gene Set 1.763e-10 427 1.005e-08 44 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. www.ncbi.nlm.ni...
PMID 11401437 View Gene Set 3.517e-10 27 1.96e-08 45 A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. www.ncbi.nlm.ni...
PMID 15883184 View Gene Set 4.924e-10 31 2.684e-08 46 Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. www.ncbi.nlm.ni...
PMID 17289661 View Gene Set 5.355e-10 35 2.856e-08 47 Molecular composition of IMP1 ribonucleoprotein granules. www.ncbi.nlm.ni...
PMID 8706699 View Gene Set 5.734e-10 35 2.995e-08 48 Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing and mass spectrometry. www.ncbi.nlm.ni...
PMID 12388589 View Gene Set 1.014e-09 17 5.189e-08 49 A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. www.ncbi.nlm.ni...
PMID 8619474 View Gene Set 1.263e-09 534 6.332e-08 50 A "double adaptor" method for improved shotgun library construction. www.ncbi.nlm.ni...
PMID 17148452 View Gene Set 1.389e-09 87 6.828e-08 51 Characterization of the interactome of the human MutL homologues MLH1 PMS1 and PMS2. www.ncbi.nlm.ni...
PMID 9110174 View Gene Set 1.528e-09 528 7.368e-08 52 Large-scale concatenation cDNA sequencing. www.ncbi.nlm.ni...
PMID 11101529 View Gene Set 1.831e-09 34 8.659e-08 53 Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. www.ncbi.nlm.ni...
PMID 9653160 View Gene Set 2.806e-09 36 1.303e-07 54 Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. www.ncbi.nlm.ni...
PMID 12962325 View Gene Set 3.152e-09 22 1.437e-07 55 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. www.ncbi.nlm.ni...
PMID 18377426 View Gene Set 3.705e-09 20 1.659e-07 56 Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. www.ncbi.nlm.ni...
PMID 20508983 View Gene Set 4.148e-09 102 1.825e-07 57 Centrosome-related genes genetic variation and risk of breast cancer. www.ncbi.nlm.ni...
PMID 1602151 View Gene Set 4.38e-09 99 1.893e-07 58 Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. www.ncbi.nlm.ni...
PMID 12791267 View Gene Set 5.45e-09 50 2.316e-07 59 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. www.ncbi.nlm.ni...
PMID 15029244 View Gene Set 5.653e-09 57 2.362e-07 60 Mammalian Cdh1/Fzr mediates its own degradation. www.ncbi.nlm.ni...
PMID 18809582 View Gene Set 8.586e-09 25 3.529e-07 61 Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. www.ncbi.nlm.ni...
PMID 12234937 View Gene Set 1.714e-08 34 6.932e-07 62 Characterization of novel SF3b and 17S U2 snRNP proteins including a human Prp5p homologue and an SF3b DEAD-box protein. www.ncbi.nlm.ni...
PMID 11230166 View Gene Set 1.883e-08 748 7.495e-07 63 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. www.ncbi.nlm.ni...
PMID 15456888 View Gene Set 2.164e-08 24 8.478e-07 64 The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. www.ncbi.nlm.ni...
PMID 15146197 View Gene Set 2.918e-08 693 1.126e-06 65 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. www.ncbi.nlm.ni...
PMID 14564014 View Gene Set 3.023e-08 47 1.148e-06 66 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. www.ncbi.nlm.ni...
PMID 11279123 View Gene Set 5.799e-08 31 2.141e-06 67 The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 1286669 View Gene Set 5.806e-08 28 2.141e-06 67 Human liver protein map: a reference database established by microsequencing and gel comparison. www.ncbi.nlm.ni...
PMID 18162579 View Gene Set 6.242e-08 22 2.268e-06 69 Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. www.ncbi.nlm.ni...
PMID 10893419 View Gene Set 9.573e-08 41 3.288e-06 70 Degradation of HIV-1 integrase by the N-end rule pathway. www.ncbi.nlm.ni...
PMID 12419264 View Gene Set 9.573e-08 41 3.288e-06 70 The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. www.ncbi.nlm.ni...
PMID 14550573 View Gene Set 9.573e-08 41 3.288e-06 70 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. www.ncbi.nlm.ni...
PMID 9079628 View Gene Set 9.573e-08 41 3.288e-06 70 HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. www.ncbi.nlm.ni...
PMID 11076863 View Gene Set 1.275e-07 794 4.319e-06 74 DNA cloning using in vitro site-specific recombination. www.ncbi.nlm.ni...
PMID 12719574 View Gene Set 1.834e-07 42 5.541e-06 75 Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. www.ncbi.nlm.ni...
PMID 12750511 View Gene Set 1.834e-07 42 5.541e-06 75 Hypermutation of HIV-1 DNA in the absence of the Vif protein. www.ncbi.nlm.ni...
PMID 12830140 View Gene Set 1.834e-07 42 5.541e-06 75 DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. www.ncbi.nlm.ni...
PMID 12840737 View Gene Set 1.834e-07 42 5.541e-06 75 Good to CU. www.ncbi.nlm.ni...
PMID 12914693 View Gene Set 1.834e-07 42 5.541e-06 75 Death by deamination: a novel host restriction system for HIV-1. www.ncbi.nlm.ni...
PMID 12920286 View Gene Set 1.834e-07 42 5.541e-06 75 Virology. Weapons of mutational destruction. www.ncbi.nlm.ni...
PMID 14614829 View Gene Set 1.834e-07 42 5.541e-06 75 The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. www.ncbi.nlm.ni...
PMID 9811770 View Gene Set 1.834e-07 42 5.541e-06 75 An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. www.ncbi.nlm.ni...
PMID 9846577 View Gene Set 1.834e-07 42 5.541e-06 75 Evidence for a newly discovered cellular anti-HIV-1 phenotype. www.ncbi.nlm.ni...
PMID 12167863 View Gene Set 2.162e-07 43 5.832e-06 84 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. www.ncbi.nlm.ni...
PMID 12808465 View Gene Set 2.162e-07 43 5.832e-06 84 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. www.ncbi.nlm.ni...
PMID 12808466 View Gene Set 2.162e-07 43 5.832e-06 84 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. www.ncbi.nlm.ni...
PMID 12809610 View Gene Set 2.162e-07 43 5.832e-06 84 DNA deamination mediates innate immunity to retroviral infection. www.ncbi.nlm.ni...
PMID 12970355 View Gene Set 2.162e-07 43 5.832e-06 84 The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. www.ncbi.nlm.ni...
PMID 14527406 View Gene Set 2.162e-07 43 5.832e-06 84 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. www.ncbi.nlm.ni...
PMID 14528300 View Gene Set 2.162e-07 43 5.832e-06 84 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. www.ncbi.nlm.ni...
PMID 14528301 View Gene Set 2.162e-07 43 5.832e-06 84 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. www.ncbi.nlm.ni...
PMID 14557625 View Gene Set 2.162e-07 43 5.832e-06 84 The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15) a cellular inhibitor of virus infectivity. www.ncbi.nlm.ni...
PMID 16085932 View Gene Set 2.163e-07 18 5.832e-06 84 A novel evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. www.ncbi.nlm.ni...
PMID 16713569 View Gene Set 3.901e-07 570 1.041e-05 94 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. www.ncbi.nlm.ni...
PMID 7584044 View Gene Set 3.981e-07 41 1.051e-05 95 Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. www.ncbi.nlm.ni...
PMID 12493763 View Gene Set 6.373e-07 18 1.664e-05 96 A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. www.ncbi.nlm.ni...
PMID 12228227 View Gene Set 7.122e-07 30 1.841e-05 97 Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. www.ncbi.nlm.ni...
PMID 19237606 View Gene Set 7.266e-07 84 1.859e-05 98 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. www.ncbi.nlm.ni...
PMID 19738611 View Gene Set 7.424e-07 39 1.88e-05 99 Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. www.ncbi.nlm.ni...
PMID 11551941 View Gene Set 7.976e-07 26 2e-05 100 The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. www.ncbi.nlm.ni...
PMID 7788527 View Gene Set 9.059e-07 42 2.249e-05 101 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. www.ncbi.nlm.ni...
PMID 8811196 View Gene Set 1.048e-06 37 2.575e-05 102 Structure and functions of the 20S and 26S proteasomes. www.ncbi.nlm.ni...
PMID 19019082 View Gene Set 1.112e-06 49 2.706e-05 103 Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. www.ncbi.nlm.ni...
PMID 18063578 View Gene Set 1.127e-06 31 2.718e-05 104 The layered structure of human mitochondrial DNA nucleoids. www.ncbi.nlm.ni...
PMID 17540176 View Gene Set 1.15e-06 28 2.745e-05 105 The tumor suppressor PP2A Abeta regulates the RalA GTPase. www.ncbi.nlm.ni...
PMID 15835887 View Gene Set 1.233e-06 12 2.916e-05 106 Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61 TRAP and two potential new subunits. www.ncbi.nlm.ni...
PMID 16097034 View Gene Set 1.369e-06 36 3.178e-05 107 Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. www.ncbi.nlm.ni...
PMID 16730941 View Gene Set 1.368e-06 55 3.178e-05 107 A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. www.ncbi.nlm.ni...
PMID 10942595 View Gene Set 1.416e-06 25 3.257e-05 109 A visual intracellular classification strategy for uncharacterized human proteins. www.ncbi.nlm.ni...
PMID 12171929 View Gene Set 1.511e-06 31 3.443e-05 110 A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. www.ncbi.nlm.ni...
PMID 11031247 View Gene Set 1.56e-06 51 3.519e-05 111 Secretory protein trafficking and organelle dynamics in living cells. www.ncbi.nlm.ni...
PMID 11829477 View Gene Set 1.572e-06 13 3.519e-05 111 Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. www.ncbi.nlm.ni...
PMID 17274640 View Gene Set 1.587e-06 30 3.521e-05 113 A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. www.ncbi.nlm.ni...
PMID 9731529 View Gene Set 1.848e-06 24 4.065e-05 114 Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. www.ncbi.nlm.ni...
PMID 11013263 View Gene Set 1.909e-06 16 4.162e-05 115 A novel nuclear receptor corepressor complex N-CoR contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. www.ncbi.nlm.ni...
PMID 12754519 View Gene Set 1.949e-06 71 4.213e-05 116 Identification and quantification of N-linked glycoproteins using hydrazide chemistry stable isotope labeling and mass spectrometry. www.ncbi.nlm.ni...
PMID 12859895 View Gene Set 1.984e-06 47 4.25e-05 117 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. www.ncbi.nlm.ni...
PMID 11748230 View Gene Set 2.336e-06 17 4.928e-05 118 Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. www.ncbi.nlm.ni...
PMID 9878551 View Gene Set 2.339e-06 34 4.928e-05 118 cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. www.ncbi.nlm.ni...
PMID 20516191 View Gene Set 2.618e-06 12 5.469e-05 120 A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). www.ncbi.nlm.ni...
PMID 10725331 View Gene Set 2.758e-06 14 5.714e-05 121 Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. www.ncbi.nlm.ni...
PMID 14729942 View Gene Set 2.831e-06 18 5.818e-05 122 Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. www.ncbi.nlm.ni...
PMID 20496165 View Gene Set 2.947e-06 68 6.006e-05 123 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. www.ncbi.nlm.ni...
PMID 18697920 View Gene Set 3.195e-06 14 6.459e-05 124 The role of human ribosomal proteins in the maturation of rRNA and ribosome production. www.ncbi.nlm.ni...
PMID 15383276 View Gene Set 3.268e-06 67 6.554e-05 125 A protein interaction network links GIT1 an enhancer of huntingtin aggregation to Huntington's disease. www.ncbi.nlm.ni...
PMID 9150948 View Gene Set 3.503e-06 15 6.97e-05 126 A two-dimensional gel database of human colon carcinoma proteins. www.ncbi.nlm.ni...
PMID 15130578 View Gene Set 3.865e-06 22 7.629e-05 127 Why do cells need an assembly machine for RNA-protein complexes? www.ncbi.nlm.ni...
PMID 12761501 View Gene Set 4.082e-06 94 7.995e-05 128 Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. www.ncbi.nlm.ni...
PMID 18715871 View Gene Set 4.368e-06 20 8.489e-05 129 PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. www.ncbi.nlm.ni...
PMID 15232106 View Gene Set 4.523e-06 30 8.722e-05 130 Self-assembling protein microarrays. www.ncbi.nlm.ni...
PMID 8076819 View Gene Set 5.139e-06 37 9.834e-05 131 The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. www.ncbi.nlm.ni...
PMID 10766737 View Gene Set 6.583e-06 11 0.0001215 132 Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. www.ncbi.nlm.ni...
PMID 11714285 View Gene Set 6.785e-06 11 0.0001215 132 The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. www.ncbi.nlm.ni...
PMID 1286667 View Gene Set 6.425e-06 45 0.0001215 132 Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. www.ncbi.nlm.ni...
PMID 15009096 View Gene Set 6.832e-06 39 0.0001215 132 Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex while BMI-1 is transiently co-localized with the centromeric region in interphase. www.ncbi.nlm.ni...
PMID 16055448 View Gene Set 6.785e-06 11 0.0001215 132 The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. www.ncbi.nlm.ni...
PMID 8052601 View Gene Set 6.785e-06 11 0.0001215 132 Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. www.ncbi.nlm.ni...
PMID 8078941 View Gene Set 6.785e-06 11 0.0001215 132 Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. www.ncbi.nlm.ni...
PMID 8188258 View Gene Set 6.785e-06 11 0.0001215 132 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. www.ncbi.nlm.ni...
PMID 8449960 View Gene Set 6.785e-06 11 0.0001215 132 Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. www.ncbi.nlm.ni...
PMID 9278442 View Gene Set 6.785e-06 11 0.0001215 132 Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant. www.ncbi.nlm.ni...
PMID 15308636 View Gene Set 7.117e-06 25 0.0001256 142 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32 a new cycling protein that interacts with human Erv46. www.ncbi.nlm.ni...
PMID 15146077 View Gene Set 7.433e-06 32 0.0001292 143 The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. www.ncbi.nlm.ni...
PMID 16094384 View Gene Set 7.393e-06 80 0.0001292 143 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. www.ncbi.nlm.ni...
PMID 18954305 View Gene Set 7.472e-06 13 0.0001292 143 Structural basis and specificity of human otubain 1-mediated deubiquitination. www.ncbi.nlm.ni...
PMID 11713266 View Gene Set 7.618e-06 12 0.0001308 146 The methylosome a 20S complex containing JBP1 and pICln produces dimethylarginine-modified Sm proteins. www.ncbi.nlm.ni...
PMID 15504738 View Gene Set 9.031e-06 19 0.000154 147 Genes affecting the cell cycle growth maintenance and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. www.ncbi.nlm.ni...
PMID 11252894 View Gene Set 9.244e-06 44 0.0001565 148 Three ways to make a vesicle. www.ncbi.nlm.ni...
PMID 12611891 View Gene Set 9.303e-06 40 0.0001565 148 The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. www.ncbi.nlm.ni...
PMID 12791985 View Gene Set 1.008e-05 37 0.0001685 150 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. www.ncbi.nlm.ni...
PMID 7584026 View Gene Set 1.071e-05 43 0.0001778 151 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. www.ncbi.nlm.ni...
PMID 19596235 View Gene Set 1.078e-05 85 0.0001778 152 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. www.ncbi.nlm.ni...
PMID 19536092 View Gene Set 1.299e-05 55 0.0002129 153 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. www.ncbi.nlm.ni...
PMID 10601333 View Gene Set 1.377e-05 12 0.0002242 154 Gemin3: A novel DEAD box protein that interacts with SMN the spinal muscular atrophy gene product and is a component of gems. www.ncbi.nlm.ni...
PMID 20522537 View Gene Set 1.446e-05 73 0.0002339 155 Variation within DNA repair pathway genes and risk of multiple sclerosis. www.ncbi.nlm.ni...
PMID 20381070 View Gene Set 1.63e-05 40 0.0002619 156 Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. www.ncbi.nlm.ni...
PMID 10851237 View Gene Set 1.912e-05 11 0.0003053 157 Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). www.ncbi.nlm.ni...
PMID 12620389 View Gene Set 2.096e-05 23 0.0003326 158 Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. www.ncbi.nlm.ni...
PMID 9804427 View Gene Set 2.163e-05 14 0.000341 159 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. www.ncbi.nlm.ni...
PMID 12670868 View Gene Set 2.227e-05 21 0.000349 160 Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. www.ncbi.nlm.ni...
PMID 15761153 View Gene Set 2.247e-05 211 0.0003499 161 High-throughput mapping of a dynamic signaling network in mammalian cells. www.ncbi.nlm.ni...
PMID 12481031 View Gene Set 2.27e-05 21 0.0003513 162 CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. www.ncbi.nlm.ni...
PMID 16916647 View Gene Set 2.345e-05 76 0.0003607 163 Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. www.ncbi.nlm.ni...
PMID 11931757 View Gene Set 2.445e-05 22 0.0003699 164 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. www.ncbi.nlm.ni...
PMID 15647280 View Gene Set 2.45e-05 17 0.0003699 164 The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. www.ncbi.nlm.ni...
PMID 16582619 View Gene Set 2.445e-05 15 0.0003699 164 Identification of novel ARF binding proteins by two-hybrid screening. www.ncbi.nlm.ni...
PMID 16964240 View Gene Set 2.737e-05 32 0.0004106 167 Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. www.ncbi.nlm.ni...
PMID 18782753 View Gene Set 2.752e-05 45 0.0004106 167 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. www.ncbi.nlm.ni...
PMID 9763677 View Gene Set 2.801e-05 15 0.0004156 169 Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. www.ncbi.nlm.ni...
PMID 17601350 View Gene Set 2.894e-05 119 0.0004268 170 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. www.ncbi.nlm.ni...
PMID 9891079 View Gene Set 3.095e-05 15 0.0004537 171 Cyclin E associates with BAF155 and BRG1 components of the mammalian SWI-SNF complex and alters the ability of BRG1 to induce growth arrest. www.ncbi.nlm.ni...
PMID 15644312 View Gene Set 3.301e-05 10 0.0004812 172 Dissection of the mitochondrial import and assembly pathway for human Tom40. www.ncbi.nlm.ni...
PMID 8662825 View Gene Set 3.378e-05 10 0.0004895 173 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. www.ncbi.nlm.ni...
PMID 11310559 View Gene Set 3.528e-05 17 0.0005083 174 Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. www.ncbi.nlm.ni...
PMID 9121429 View Gene Set 3.655e-05 39 0.0005236 175 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. www.ncbi.nlm.ni...
PMID 10531003 View Gene Set 3.885e-05 15 0.0005534 176 Newly assembled snRNPs associate with coiled bodies before speckles suggesting a nuclear snRNP maturation pathway. www.ncbi.nlm.ni...
PMID 14966270 View Gene Set 3.936e-05 19 0.0005575 177 Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. www.ncbi.nlm.ni...
PMID 11714716 View Gene Set 4.004e-05 13 0.0005639 178 Gemin5 a novel WD repeat protein component of the SMN complex that binds Sm proteins. www.ncbi.nlm.ni...
PMID 12393188 View Gene Set 4.075e-05 15 0.0005707 179 Ku antigen an origin-specific binding protein that associates with replication proteins is required for mammalian DNA replication. www.ncbi.nlm.ni...
PMID 12840015 View Gene Set 4.153e-05 12 0.0005785 180 Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. www.ncbi.nlm.ni...
PMID 15949438 View Gene Set 4.478e-05 11 0.0006202 181 Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. www.ncbi.nlm.ni...
PMID 11205743 View Gene Set 4.58e-05 15 0.0006309 182 Polo-like kinase interacts with proteasomes and regulates their activity. www.ncbi.nlm.ni...
PMID 11531413 View Gene Set 4.608e-05 27 0.0006313 183 HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. www.ncbi.nlm.ni...
PMID 15142377 View Gene Set 5.018e-05 19 0.0006837 184 Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. www.ncbi.nlm.ni...
PMID 9822659 View Gene Set 5.276e-05 11 0.000715 185 Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. www.ncbi.nlm.ni...
PMID 9472028 View Gene Set 5.493e-05 12 0.0007404 186 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. www.ncbi.nlm.ni...
PMID 11095689 View Gene Set 5.688e-05 17 0.0007626 187 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. www.ncbi.nlm.ni...
PMID 15707391 View Gene Set 6.071e-05 23 0.0008096 188 DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. www.ncbi.nlm.ni...
PMID 12837248 View Gene Set 6.195e-05 22 0.0008217 189 The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. www.ncbi.nlm.ni...
PMID 17322308 View Gene Set 6.284e-05 13 0.0008248 190 Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. www.ncbi.nlm.ni...
PMID 18599441 View Gene Set 6.284e-05 13 0.0008248 190 Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. www.ncbi.nlm.ni...
PMID 9878398 View Gene Set 6.914e-05 13 0.0009028 192 Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. www.ncbi.nlm.ni...
PMID 9039502 View Gene Set 7.061e-05 84 0.0009172 193 Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. www.ncbi.nlm.ni...
PMID 18950845 View Gene Set 7.253e-05 88 0.0009373 194 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. www.ncbi.nlm.ni...
PMID 16712791 View Gene Set 8.038e-05 342 0.001033 195 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. www.ncbi.nlm.ni...
PMID 19183483 View Gene Set 8.508e-05 17 0.001088 196 Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. www.ncbi.nlm.ni...
PMID 11742988 View Gene Set 8.777e-05 20 0.001117 197 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. www.ncbi.nlm.ni...
PMID 11279069 View Gene Set 8.828e-05 15 0.001118 198 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. www.ncbi.nlm.ni...
PMID 11102443 View Gene Set 9.17e-05 14 0.001154 199 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. www.ncbi.nlm.ni...
PMID 15265780 View Gene Set 9.202e-05 14 0.001154 199 Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? www.ncbi.nlm.ni...

Gene Set Collection: ChromosomalTiles5Mb

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null chr22_37.5-42.5Mb View Gene Set 1.235e-06 59 0.001375 1 Genomic tile: chr22 ; 37500001-42500001 Mb genome.ucsc.edu...
Null chr1_220-225Mb View Gene Set 6.979e-06 28 0.003888 2 Genomic tile: chr1 ; 220000001-225000001 Mb genome.ucsc.edu...
Null chr5_67.5-72.5Mb View Gene Set 1.601e-05 16 0.005947 3 Genomic tile: chr5 ; 67500001-72500001 Mb genome.ucsc.edu...
Null chr1_217.5-222.5Mb View Gene Set 3.596e-05 15 0.01001 4 Genomic tile: chr1 ; 217500001-222500001 Mb genome.ucsc.edu...
Null chr1_42.5-47.5Mb View Gene Set 6.571e-05 68 0.01464 5 Genomic tile: chr1 ; 42500001-47500001 Mb genome.ucsc.edu...
Null chr11_60-65Mb View Gene Set 9.936e-05 104 0.01845 6 Genomic tile: chr11 ; 60000001-65000001 Mb genome.ucsc.edu...
Null chr22_40-45Mb View Gene Set 0.0001169 51 0.01861 7 Genomic tile: chr22 ; 40000001-45000001 Mb genome.ucsc.edu...
Null chr14_17.5-22.5Mb View Gene Set 0.0001873 50 0.01899 8 Genomic tile: chr14 ; 17500001-22500001 Mb genome.ucsc.edu...
Null chr16_42.5-47.5Mb View Gene Set 0.0001416 8 0.01899 8 Genomic tile: chr16 ; 42500001-47500001 Mb genome.ucsc.edu...
Null chr17_2.5-7.5Mb View Gene Set 0.0001875 77 0.01899 8 Genomic tile: chr17 ; 2500001-7500001 Mb genome.ucsc.edu...
Null chr17_5-10Mb View Gene Set 0.0001593 90 0.01899 8 Genomic tile: chr17 ; 5000001-10000001 Mb genome.ucsc.edu...
Null chr3_45-50Mb View Gene Set 0.0002179 72 0.02023 12 Genomic tile: chr3 ; 45000001-50000001 Mb genome.ucsc.edu...
Null chr19_35-40Mb View Gene Set 0.0005537 25 0.04745 13 Genomic tile: chr19 ; 35000001-40000001 Mb genome.ucsc.edu...

Gene Set Collection: Prosite

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null PS50102 View Gene Set 1.316e-18 229 9.676e-16 1 RRM expasy.org/pros...
Null PS50127 View Gene Set 2.429e-08 41 8.925e-06 2 UBIQUITIN_CONJUGAT_2 expasy.org/pros...
Null PS00183 View Gene Set 2.889e-06 25 0.0006499 3 UBIQUITIN_CONJUGAT_1 expasy.org/pros...
Null PS51192 View Gene Set 3.537e-06 112 0.0006499 3 HELICASE_ATP_BIND_1 expasy.org/pros...
Null PS51352 View Gene Set 5.804e-06 36 0.0008531 5 THIOREDOXIN_2 expasy.org/pros...
Null PS51194 View Gene Set 7.158e-06 113 0.0008768 6 HELICASE_CTER expasy.org/pros...
Null PS00194 View Gene Set 1.108e-05 17 0.001164 7 THIOREDOXIN_1 expasy.org/pros...
Null PS51195 View Gene Set 1.327e-05 37 0.001219 8 Q_MOTIF expasy.org/pros...
Null PS00178 View Gene Set 2.018e-05 15 0.001648 9 AA_TRNA_LIGASE_I expasy.org/pros...
Null PS00674 View Gene Set 3.015e-05 29 0.002073 10 AAA expasy.org/pros...
Null PS00750 View Gene Set 3.666e-05 9 0.002073 10 TCP1_1 expasy.org/pros...
Null PS00751 View Gene Set 3.666e-05 9 0.002073 10 TCP1_2 expasy.org/pros...
Null PS00995 View Gene Set 3.666e-05 9 0.002073 10 TCP1_3 expasy.org/pros...
Null PS50293 View Gene Set 7.058e-05 134 0.003705 14 TPR_REGION expasy.org/pros...
Null PS00299 View Gene Set 0.0001289 10 0.006315 15 UBIQUITIN_1 expasy.org/pros...
Null PS00039 View Gene Set 0.000243 27 0.008505 16 DEAD_ATP_HELICASE expasy.org/pros...
Null PS00847 View Gene Set 0.0001973 6 0.008505 16 MCM_1 expasy.org/pros...
Null PS50005 View Gene Set 0.0002301 114 0.008505 16 TPR expasy.org/pros...
Null PS50053 View Gene Set 0.0002204 58 0.008505 16 UBIQUITIN_2 expasy.org/pros...
Null PS50082 View Gene Set 0.0002234 233 0.008505 16 WD_REPEATS_2 expasy.org/pros...
Null PS50166 View Gene Set 0.0002376 13 0.008505 16 IMPORTIN_B_NT expasy.org/pros...
Null PS50072 View Gene Set 0.0002609 35 0.008715 22 CSA_PPIASE_2 expasy.org/pros...
Null PS00170 View Gene Set 0.0002935 25 0.009378 23 CSA_PPIASE_1 expasy.org/pros...
Null PS00301 View Gene Set 0.0004057 11 0.01193 24 EFACTOR_GTP expasy.org/pros...
Null PS50051 View Gene Set 0.0003925 8 0.01193 24 MCM_2 expasy.org/pros...
Null PS50089 View Gene Set 0.0006138 301 0.01735 26 ZF_RING_2 expasy.org/pros...
Null PS50920 View Gene Set 0.0008426 59 0.02294 27 SOLCAR expasy.org/pros...
Null PS00125 View Gene Set 0.001004 13 0.02636 28 SER_THR_PHOSPHATASE expasy.org/pros...
Null PS51151 View Gene Set 0.001157 9 0.02932 29 NAC_AB expasy.org/pros...
Null PS50137 View Gene Set 0.001419 20 0.0298 30 DS_RBD expasy.org/pros...
Null PS50294 View Gene Set 0.00134 245 0.0298 30 WD_REPEATS_REGION expasy.org/pros...
Null PS50800 View Gene Set 0.00138 23 0.0298 30 SAP expasy.org/pros...
Null PS50908 View Gene Set 0.001224 10 0.0298 30 RWD expasy.org/pros...
Null PS51293 View Gene Set 0.001346 26 0.0298 30 SANT expasy.org/pros...
Null PS51309 View Gene Set 0.001314 7 0.0298 30 PABC expasy.org/pros...
Null PS00113 View Gene Set 0.001839 6 0.03747 36 ADENYLATE_KINASE expasy.org/pros...
Null PS50867 View Gene Set 0.001886 7 0.03747 36 PRE_SET expasy.org/pros...
Null PS00678 View Gene Set 0.001997 168 0.03862 38 WD_REPEATS_1 expasy.org/pros...
Null PS01359 View Gene Set 0.002523 72 0.04523 39 ZF_PHD_1 expasy.org/pros...
Null PS50866 View Gene Set 0.002459 19 0.04523 39 GOLD expasy.org/pros...
Null PS50922 View Gene Set 0.002469 16 0.04523 39 TLC expasy.org/pros...
Null PS00470 View Gene Set 0.00261 5 0.04545 42 IDH_IMDH expasy.org/pros...
Null PS50103 View Gene Set 0.002887 60 0.04545 42 ZF_C3H1 expasy.org/pros...
Null PS50171 View Gene Set 0.002774 9 0.04545 42 ZF_MATRIN expasy.org/pros...
Null PS50296 View Gene Set 0.002906 6 0.04545 42 SUI1 expasy.org/pros...
Null PS50862 View Gene Set 0.00285 18 0.04545 42 AA_TRNA_LIGASE_II expasy.org/pros...
Null PS51038 View Gene Set 0.002774 11 0.04545 42 BAH expasy.org/pros...
Null PS50969 View Gene Set 0.002968 8 0.04545 48 FCP1 expasy.org/pros...
Null PS51316 View Gene Set 0.003132 19 0.04698 49 NBPF expasy.org/pros...
Null PS51391 View Gene Set 0.003268 8 0.0471 50 CID expasy.org/pros...
Null PS51419 View Gene Set 0.003225 83 0.0471 50 RAB expasy.org/pros...
Null PS50255 View Gene Set 0.003496 11 0.04942 52 CYTOCHROME_B5_2 expasy.org/pros...

Gene Set Collection: Enzyme

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null EC:6.3.2.19 View Gene Set 6.058e-11 79 9.571e-09 1 Ubiquitin--protein ligase expasy.org/enzy...
Null EC:1.6.99.3 View Gene Set 4.658e-06 35 0.0003366 2 NADH dehydrogenase expasy.org/enzy...
Null EC:2.1.1.43 View Gene Set 6.392e-06 19 0.0003366 2 Histone-lysine N-methyltransferase expasy.org/enzy...
Null EC:1.6.5.3 View Gene Set 9.642e-06 43 0.0003808 4 NADH dehydrogenase (ubiquinone) expasy.org/enzy...
Null EC:2.7.11.1 View Gene Set 5.421e-05 91 0.001713 5 Non-specific serine/threonine protein kinase expasy.org/enzy...
Null EC:1.10.2.2 View Gene Set 0.0001311 13 0.003453 6 Ubiquinol--cytochrome-c reductase expasy.org/enzy...
Null EC:3.6.3.14 View Gene Set 0.0003753 45 0.00847 7 H(+)-transporting two-sector ATPase expasy.org/enzy...
Null EC:3.4.25.1 View Gene Set 0.001471 20 0.02905 8 Proteasome endopeptidase complex expasy.org/enzy...
Null EC:5.3.4.1 View Gene Set 0.001828 4 0.03208 9 Protein disulfide-isomerase expasy.org/enzy...

Gene Set Collection: ppi.BIND

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.CDKN1A View Gene Set 3.83e-05 9 0.004705 1 Protein-protein-interaction for CDKN1A www.ncbi.nlm.ni...
Null ppi.E2F1 View Gene Set 8.156e-05 12 0.004705 1 Protein-protein-interaction for E2F1 www.ncbi.nlm.ni...
Null ppi.ARHGAP8 View Gene Set 9.958e-05 8 0.004705 1 Protein-protein-interaction for ARHGAP8 www.ncbi.nlm.ni...
Null ppi.RB1 View Gene Set 7.276e-05 44 0.004705 1 Protein-protein-interaction for RB1 www.ncbi.nlm.ni...
Null ppi.1491938 View Gene Set 0.0002096 25 0.004951 5 Protein-protein-interaction for 1491938 www.ncbi.nlm.ni...
Null ppi.MYC View Gene Set 0.0002004 16 0.004951 5 Protein-protein-interaction for MYC www.ncbi.nlm.ni...
Null ppi.RBL2 View Gene Set 0.0001925 14 0.004951 5 Protein-protein-interaction for RBL2 www.ncbi.nlm.ni...
Null ppi.YY1 View Gene Set 0.0001768 9 0.004951 5 Protein-protein-interaction for YY1 www.ncbi.nlm.ni...
Null ppi.E2F4 View Gene Set 0.0003317 14 0.006269 9 Protein-protein-interaction for E2F4 www.ncbi.nlm.ni...
Null ppi.UXT View Gene Set 0.0003236 8 0.006269 9 Protein-protein-interaction for UXT www.ncbi.nlm.ni...
Null ppi.RIBIN View Gene Set 0.000435 8 0.007474 11 Protein-protein-interaction for RIBIN www.ncbi.nlm.ni...
Null ppi.RNF11 View Gene Set 0.0006053 8 0.009533 12 Protein-protein-interaction for RNF11 www.ncbi.nlm.ni...
Null ppi.RALBP1 View Gene Set 0.001418 7 0.01915 13 Protein-protein-interaction for RALBP1 www.ncbi.nlm.ni...
Null ppi.MDM2 View Gene Set 0.001384 5 0.01915 13 Protein-protein-interaction for MDM2 www.ncbi.nlm.ni...
Null ppi.GEMIN6 View Gene Set 0.001562 7 0.01968 15 Protein-protein-interaction for GEMIN6 www.ncbi.nlm.ni...
Null ppi.PCNA View Gene Set 0.001893 11 0.02236 16 Protein-protein-interaction for PCNA www.ncbi.nlm.ni...
Null ppi.NCF1C View Gene Set 0.002011 7 0.02236 16 Protein-protein-interaction for NCF1C www.ncbi.nlm.ni...
Null ppi.155871 View Gene Set 0.00234 21 0.02328 18 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.SNORD3A View Gene Set 0.002313 9 0.02328 18 Protein-protein-interaction for SNORD3A www.ncbi.nlm.ni...
Null ppi.PAK1 View Gene Set 0.002702 7 0.02553 20 Protein-protein-interaction for PAK1 www.ncbi.nlm.ni...
Null ppi.CCNA1 View Gene Set 0.003067 11 0.02657 21 Protein-protein-interaction for CCNA1 www.ncbi.nlm.ni...
Null ppi.951475 View Gene Set 0.003093 43 0.02657 21 Protein-protein-interaction for 951475 www.ncbi.nlm.ni...
Null ppi.PKP3 View Gene Set 0.004348 10 0.03044 23 Protein-protein-interaction for PKP3 www.ncbi.nlm.ni...
Null ppi.COPS4 View Gene Set 0.004058 7 0.03044 23 Protein-protein-interaction for COPS4 www.ncbi.nlm.ni...
Null ppi.PRNP View Gene Set 0.004015 7 0.03044 23 Protein-protein-interaction for PRNP www.ncbi.nlm.ni...
Null ppi.MOAP1 View Gene Set 0.004099 7 0.03044 23 Protein-protein-interaction for MOAP1 www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 0.004313 8 0.03044 23 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.BACE1 View Gene Set 0.004843 7 0.03269 28 Protein-protein-interaction for BACE1 www.ncbi.nlm.ni...

Gene Set Collection: ppi.BioGRID

Arguments: refPop=all, featureType=ENTREZID, colname=WilcoxDOWN, ranks.only=TRUE, absolute=FALSE, alternative=down

Gene Set Name GeneSetDescription Value Gene Set Size Corrected Value Ranking Description URL
Null ppi.155871 View Gene Set 3.047e-36 236 7e-33 1 Protein-protein-interaction for 155871 www.ncbi.nlm.ni...
Null ppi.MEPCE View Gene Set 1.323e-32 147 1.519e-29 2 Protein-protein-interaction for MEPCE www.ncbi.nlm.ni...
Null ppi.SRRM2 View Gene Set 2.256e-19 101 1.727e-16 3 Protein-protein-interaction for SRRM2 www.ncbi.nlm.ni...
Null ppi.KHDRBS2 View Gene Set 1.161e-14 46 6.669e-12 4 Protein-protein-interaction for KHDRBS2 www.ncbi.nlm.ni...
Null ppi.TP53 View Gene Set 4.699e-14 168 2.159e-11 5 Protein-protein-interaction for TP53 www.ncbi.nlm.ni...
Null ppi.72462 View Gene Set 2.329e-13 42 8.915e-11 6 Protein-protein-interaction for 72462 www.ncbi.nlm.ni...
Null ppi.SRRM1 View Gene Set 5.108e-13 64 1.676e-10 7 Protein-protein-interaction for SRRM1 www.ncbi.nlm.ni...
Null ppi.RUVBL2 View Gene Set 9.733e-12 64 2.794e-09 8 Protein-protein-interaction for RUVBL2 www.ncbi.nlm.ni...
Null ppi.DDA1 View Gene Set 4.864e-11 44 1.241e-08 9 Protein-protein-interaction for DDA1 www.ncbi.nlm.ni...
Null ppi.GSTK1 View Gene Set 1.776e-10 26 4.081e-08 10 Protein-protein-interaction for GSTK1 www.ncbi.nlm.ni...
Null ppi.TOPORS View Gene Set 3.257e-10 27 6.801e-08 11 Protein-protein-interaction for TOPORS www.ncbi.nlm.ni...
Null ppi.SUMO2 View Gene Set 2.054e-09 50 3.931e-07 12 Protein-protein-interaction for SUMO2 www.ncbi.nlm.ni...
Null ppi.GPN1 View Gene Set 5.823e-09 27 1.029e-06 13 Protein-protein-interaction for GPN1 www.ncbi.nlm.ni...
Null ppi.TCERG1 View Gene Set 7.73e-09 35 1.184e-06 14 Protein-protein-interaction for TCERG1 www.ncbi.nlm.ni...
Null ppi.WBP4 View Gene Set 7.401e-09 35 1.184e-06 14 Protein-protein-interaction for WBP4 www.ncbi.nlm.ni...
Null ppi.RNPS1 View Gene Set 8.327e-09 38 1.195e-06 16 Protein-protein-interaction for RNPS1 www.ncbi.nlm.ni...
Null ppi.CDT1 View Gene Set 1.346e-08 37 1.818e-06 17 Protein-protein-interaction for CDT1 www.ncbi.nlm.ni...
Null ppi.UCHL5 View Gene Set 1.916e-08 33 2.41e-06 18 Protein-protein-interaction for UCHL5 www.ncbi.nlm.ni...
Null ppi.RUVBL1 View Gene Set 1.993e-08 38 2.41e-06 18 Protein-protein-interaction for RUVBL1 www.ncbi.nlm.ni...
Null ppi.EIF1B View Gene Set 2.3e-08 25 2.641e-06 20 Protein-protein-interaction for EIF1B www.ncbi.nlm.ni...
Null ppi.TH1L View Gene Set 3.043e-08 26 3.177e-06 21 Protein-protein-interaction for TH1L www.ncbi.nlm.ni...
Null ppi.UBA5 View Gene Set 2.908e-08 35 3.177e-06 21 Protein-protein-interaction for UBA5 www.ncbi.nlm.ni...
Null ppi.BANF1 View Gene Set 3.388e-08 34 3.384e-06 23 Protein-protein-interaction for BANF1 www.ncbi.nlm.ni...
Null ppi.EIF3F View Gene Set 3.692e-08 22 3.534e-06 24 Protein-protein-interaction for EIF3F www.ncbi.nlm.ni...
Null ppi.PRPF40A View Gene Set 4.085e-08 53 3.753e-06 25 Protein-protein-interaction for PRPF40A www.ncbi.nlm.ni...
Null ppi.DDX56 View Gene Set 5.904e-08 20 5.216e-06 26 Protein-protein-interaction for DDX56 www.ncbi.nlm.ni...
Null ppi.LYAR View Gene Set 7.65e-08 26 6.508e-06 27 Protein-protein-interaction for LYAR www.ncbi.nlm.ni...
Null ppi.DDX20 View Gene Set 8.852e-08 17 7.262e-06 28 Protein-protein-interaction for DDX20 www.ncbi.nlm.ni...
Null ppi.KIAA1377 View Gene Set 9.669e-08 57 7.659e-06 29 Protein-protein-interaction for KIAA1377 www.ncbi.nlm.ni...
Null ppi.MGMT View Gene Set 1.407e-07 28 1.077e-05 30 Protein-protein-interaction for MGMT www.ncbi.nlm.ni...
Null ppi.RRP1B View Gene Set 1.752e-07 21 1.298e-05 31 Protein-protein-interaction for RRP1B www.ncbi.nlm.ni...
Null ppi.STRN3 View Gene Set 2.952e-07 22 2.119e-05 32 Protein-protein-interaction for STRN3 www.ncbi.nlm.ni...
Null ppi.MYC View Gene Set 3.064e-07 42 2.133e-05 33 Protein-protein-interaction for MYC www.ncbi.nlm.ni...
Null ppi.PABPC1 View Gene Set 3.822e-07 26 2.582e-05 34 Protein-protein-interaction for PABPC1 www.ncbi.nlm.ni...
Null ppi.PAAF1 View Gene Set 4.056e-07 20 2.623e-05 35 Protein-protein-interaction for PAAF1 www.ncbi.nlm.ni...
Null ppi.HIST1H4A View Gene Set 4.111e-07 28 2.623e-05 35 Protein-protein-interaction for HIST1H4A www.ncbi.nlm.ni...
Null ppi.CBX5 View Gene Set 4.8e-07 38 2.902e-05 37 Protein-protein-interaction for CBX5 www.ncbi.nlm.ni...
Null ppi.SIN3A View Gene Set 4.68e-07 104 2.902e-05 37 Protein-protein-interaction for SIN3A www.ncbi.nlm.ni...
Null ppi.MTA2 View Gene Set 4.941e-07 25 2.91e-05 39 Protein-protein-interaction for MTA2 www.ncbi.nlm.ni...
Null ppi.COPS6 View Gene Set 6.692e-07 65 3.749e-05 40 Protein-protein-interaction for COPS6 www.ncbi.nlm.ni...
Null ppi.ZMYM2 View Gene Set 6.567e-07 14 3.749e-05 40 Protein-protein-interaction for ZMYM2 www.ncbi.nlm.ni...
Null ppi.BRF2 View Gene Set 7.404e-07 23 4.049e-05 42 Protein-protein-interaction for BRF2 www.ncbi.nlm.ni...
Null ppi.UIMC1 View Gene Set 7.608e-07 30 4.064e-05 43 Protein-protein-interaction for UIMC1 www.ncbi.nlm.ni...
Null ppi.PINX1 View Gene Set 1.067e-06 19 5.573e-05 44 Protein-protein-interaction for PINX1 www.ncbi.nlm.ni...
Null ppi.RB1 View Gene Set 1.354e-06 46 6.91e-05 45 Protein-protein-interaction for RB1 www.ncbi.nlm.ni...
Null ppi.MBD2 View Gene Set 1.384e-06 11 6.913e-05 46 Protein-protein-interaction for MBD2 www.ncbi.nlm.ni...
Null ppi.BRCC3 View Gene Set 1.574e-06 22 7.694e-05 47 Protein-protein-interaction for BRCC3 www.ncbi.nlm.ni...
Null ppi.WDR48 View Gene Set 1.623e-06 52 7.768e-05 48 Protein-protein-interaction for WDR48 www.ncbi.nlm.ni...
Null ppi.CNBP View Gene Set 1.83e-06 17 8.578e-05 49 Protein-protein-interaction for CNBP www.ncbi.nlm.ni...
Null ppi.DZIP3 View Gene Set 2.731e-06 18 0.0001255 50 Protein-protein-interaction for DZIP3 www.ncbi.nlm.ni...
Null ppi.VHL View Gene Set 2.788e-06 50 0.0001256 51 Protein-protein-interaction for VHL www.ncbi.nlm.ni...
Null ppi.SAP25 View Gene Set 3.19e-06 29 0.0001409 52 Protein-protein-interaction for SAP25 www.ncbi.nlm.ni...
Null ppi.CHFR View Gene Set 4.317e-06 18 0.0001871 53 Protein-protein-interaction for CHFR www.ncbi.nlm.ni...
Null ppi.SMARCA2 View Gene Set 4.484e-06 29 0.0001907 54 Protein-protein-interaction for SMARCA2 www.ncbi.nlm.ni...
Null ppi.USP14 View Gene Set 5.079e-06 22 0.0002121 55 Protein-protein-interaction for USP14 www.ncbi.nlm.ni...
Null ppi.MKRN3 View Gene Set 5.277e-06 14 0.0002165 56 Protein-protein-interaction for MKRN3 www.ncbi.nlm.ni...
Null ppi.RPAP1 View Gene Set 5.815e-06 24 0.0002343 57 Protein-protein-interaction for RPAP1 www.ncbi.nlm.ni...
Null ppi.AKTIP View Gene Set 6.295e-06 21 0.0002493 58 Protein-protein-interaction for AKTIP www.ncbi.nlm.ni...
Null ppi.MOBKL3 View Gene Set 6.476e-06 34 0.0002521 59 Protein-protein-interaction for MOBKL3 www.ncbi.nlm.ni...
Null ppi.XRN1 View Gene Set 7.074e-06 12 0.0002708 60 Protein-protein-interaction for XRN1 www.ncbi.nlm.ni...
Null ppi.PSMD6 View Gene Set 7.667e-06 21 0.0002887 61 Protein-protein-interaction for PSMD6 www.ncbi.nlm.ni...
Null ppi.WDR8 View Gene Set 8.131e-06 23 0.0003012 62 Protein-protein-interaction for WDR8 www.ncbi.nlm.ni...
Null ppi.KAT5 View Gene Set 8.408e-06 51 0.0003066 63 Protein-protein-interaction for KAT5 www.ncbi.nlm.ni...
Null ppi.EIF3B View Gene Set 9.341e-06 10 0.0003353 64 Protein-protein-interaction for EIF3B www.ncbi.nlm.ni...
Null ppi.UBE2I View Gene Set 1.037e-05 62 0.000365 65 Protein-protein-interaction for UBE2I www.ncbi.nlm.ni...
Null ppi.EIF3A View Gene Set 1.049e-05 12 0.000365 65 Protein-protein-interaction for EIF3A www.ncbi.nlm.ni...
Null ppi.HDAC2 View Gene Set 1.159e-05 34 0.0003938 67 Protein-protein-interaction for HDAC2 www.ncbi.nlm.ni...
Null ppi.NPM1 View Gene Set 1.166e-05 16 0.0003938 67 Protein-protein-interaction for NPM1 www.ncbi.nlm.ni...
Null ppi.RCOR1 View Gene Set 1.193e-05 21 0.0003973 69 Protein-protein-interaction for RCOR1 www.ncbi.nlm.ni...
Null ppi.ORC2L View Gene Set 1.269e-05 12 0.0004164 70 Protein-protein-interaction for ORC2L www.ncbi.nlm.ni...
Null ppi.TRIM5 View Gene Set 1.487e-05 14 0.0004811 71 Protein-protein-interaction for TRIM5 www.ncbi.nlm.ni...
Null ppi.PSMD13 View Gene Set 1.653e-05 20 0.0005229 72 Protein-protein-interaction for PSMD13 www.ncbi.nlm.ni...
Null ppi.TRIB3 View Gene Set 1.662e-05 24 0.0005229 72 Protein-protein-interaction for TRIB3 www.ncbi.nlm.ni...
Null ppi.HNRNPR View Gene Set 1.868e-05 9 0.0005799 74 Protein-protein-interaction for HNRNPR www.ncbi.nlm.ni...
Null ppi.HIST3H3 View Gene Set 1.936e-05 16 0.000593 75 Protein-protein-interaction for HIST3H3 www.ncbi.nlm.ni...
Null ppi.PSMD14 View Gene Set 2.133e-05 16 0.0006363 76 Protein-protein-interaction for PSMD14 www.ncbi.nlm.ni...
Null ppi.SP1 View Gene Set 2.115e-05 79 0.0006363 76 Protein-protein-interaction for SP1 www.ncbi.nlm.ni...
Null ppi.SSRP1 View Gene Set 2.199e-05 15 0.0006475 78 Protein-protein-interaction for SSRP1 www.ncbi.nlm.ni...
Null ppi.YY1 View Gene Set 2.267e-05 34 0.0006593 79 Protein-protein-interaction for YY1 www.ncbi.nlm.ni...
Null ppi.EEF1G View Gene Set 2.373e-05 9 0.0006809 80 Protein-protein-interaction for EEF1G www.ncbi.nlm.ni...
Null ppi.ARFIP2 View Gene Set 2.46e-05 9 0.0006809 80 Protein-protein-interaction for ARFIP2 www.ncbi.nlm.ni...
Null ppi.C12orf44 View Gene Set 2.445e-05 32 0.0006809 80 Protein-protein-interaction for C12orf44 www.ncbi.nlm.ni...
Null ppi.XRCC5 View Gene Set 2.461e-05 40 0.0006809 80 Protein-protein-interaction for XRCC5 www.ncbi.nlm.ni...
Null ppi.CARM1 View Gene Set 2.612e-05 32 0.0007059 84 Protein-protein-interaction for CARM1 www.ncbi.nlm.ni...
Null ppi.BRE View Gene Set 2.6e-05 16 0.0007059 84 Protein-protein-interaction for BRE www.ncbi.nlm.ni...
Null ppi.C1orf103 View Gene Set 2.762e-05 95 0.0007377 86 Protein-protein-interaction for C1orf103 www.ncbi.nlm.ni...
Null ppi.IKBKE View Gene Set 2.807e-05 19 0.0007411 87 Protein-protein-interaction for IKBKE www.ncbi.nlm.ni...
Null ppi.MTA1 View Gene Set 2.844e-05 21 0.0007424 88 Protein-protein-interaction for MTA1 www.ncbi.nlm.ni...
Null ppi.SF3B1 View Gene Set 2.901e-05 24 0.0007483 89 Protein-protein-interaction for SF3B1 www.ncbi.nlm.ni...
Null ppi.HDAC1 View Gene Set 2.932e-05 67 0.0007483 89 Protein-protein-interaction for HDAC1 www.ncbi.nlm.ni...
Null ppi.THRA View Gene Set 3.054e-05 16 0.0007624 91 Protein-protein-interaction for THRA www.ncbi.nlm.ni...
Null ppi.GIYD2 View Gene Set 3.024e-05 32 0.0007624 91 Protein-protein-interaction for GIYD2 www.ncbi.nlm.ni...
Null ppi.C19orf62 View Gene Set 3.219e-05 29 0.0007867 93 Protein-protein-interaction for C19orf62 www.ncbi.nlm.ni...
Null ppi.HDAC3 View Gene Set 3.208e-05 92 0.0007867 93 Protein-protein-interaction for HDAC3 www.ncbi.nlm.ni...
Null ppi.TMBIM4 View Gene Set 3.579e-05 9 0.0008304 95 Protein-protein-interaction for TMBIM4 www.ncbi.nlm.ni...
Null ppi.RNF111 View Gene Set 3.527e-05 20 0.0008304 95 Protein-protein-interaction for RNF111 www.ncbi.nlm.ni...
Null ppi.C20orf24 View Gene Set 3.503e-05 20 0.0008304 95 Protein-protein-interaction for C20orf24 www.ncbi.nlm.ni...
Null ppi.DDX24 View Gene Set 3.566e-05 20 0.0008304 95 Protein-protein-interaction for DDX24 www.ncbi.nlm.ni...
Null ppi.SF3A2 View Gene Set 3.457e-05 16 0.0008304 95 Protein-protein-interaction for SF3A2 www.ncbi.nlm.ni...
Null ppi.PDCD4 View Gene Set 3.786e-05 10 0.0008697 100 Protein-protein-interaction for PDCD4 www.ncbi.nlm.ni...
Null ppi.RNU12-2P View Gene Set 3.905e-05 18 0.0008793 101 Protein-protein-interaction for RNU12-2P www.ncbi.nlm.ni...
Null ppi.RNU11 View Gene Set 3.905e-05 18 0.0008793 101 Protein-protein-interaction for RNU11 www.ncbi.nlm.ni...
Null ppi.MCM7 View Gene Set 3.943e-05 11 0.0008793 101 Protein-protein-interaction for MCM7 www.ncbi.nlm.ni...
Null ppi.RFWD2 View Gene Set 4.51e-05 26 0.0009961 104 Protein-protein-interaction for RFWD2 www.ncbi.nlm.ni...
Null ppi.STIP1 View Gene Set 4.65e-05 12 0.001017 105 Protein-protein-interaction for STIP1 w